@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0072: (2015-12-12 )
MSILAEKLSSILKRYDELTALLSSVEVVSDIKKLTELSKEQSSIEEISVASKEYLSVLEGIKENKELLEDKELSELAKEELKILEIQKSELETAIKQLLIPKDPNDDKNIYLELRAGTGGDEAGIFVGDLFKAYCRYADLKKWKVEIVSSSENSVGGYKEIIVLIKGKGVYSRLKFEAGTHRVQRVPETESQGRIHTSAITVAIMPEVDDVEVSINPSDLKIEVFRAGGHGGQCVNTTDSAVRITHLPTNISVSMQDEKSQHKNKDKALKILKARLYEKQIEEQQLANAKDRKEQVGSGDRSERIRTYNYPQNRLSEHRINLTLYSLEEIMLSGNLDEVINPLIAHAQSQFE
Atome Classification :
(20 SA)
---------------------.........10.-...-...--.---20.....------------------------...30-...-------------.....40........50--.........60.......-----.70.......--.80..-....------..90........100--..--.....110...-----...-.120-------.......130.....--------..140--.....--...150....----...160-----.......170-.--------------.......180....---...190.......200...---------....-210-...-...------..220.---..------....230....----...----.240..--------------------.---------------------.------.-----.-----------------.---250........260---------.........270...----...-----.280.......-----290...--....300.......------310-........320......---.330...--....340.......350--------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------MS
I
L
A
E
K
L
S
S
I
L
-
K
R
Y
-
D
E
L
--
T
---
A
L
L
S
S
V
E
------------------------
V
V
S
D
I
-
K
K
L
-------------
T
E
L
S
K
E
Q
S
S
I
E
E
I
S
V
A
---
S
K
E
Y
L
S
V
L
E
G
I
K
E
N
K
E
L
L
-----
E
D
K
E
L
S
E
L
A
K
--
E
E
L
K
I
-
L
E
I
Q
------
K
S
E
L
E
T
A
I
K
Q
LLIPK--DP--NDD
K
N
I
Y
L
E
L
R-----AGT-GGD
E
-------
A
G
I
F
V
G
D
L
F
K
A
Y
C
R
Y
--------ADL
K
---
K
W
K
V
E
--
I
V
SSSENSVG----G
Y
K
E
I
I
-----
V
L
I
KGKGV
Y
--
S
--------------
R
L
K
FEAGT
H
R
V
QRV---PETESQG
R
I
H
T
S
A
I
T
V
A
IM---------PEV
D
-
D
-
V
-
E
V
S
-INP------S
D
L
K
I
E
---
V
F
------
R
AGGH-G
G
Q
C
V----NTT----D
S
A
V
R
I
--------------------
T
---------------------H------L-----P-----------------T---
N
-
I
S
V
S
MQ
D
E
K
S
-----------QHK
N
K
D
K
A
L
K
I
L
K
A
R
----
L
Y
E
-----
K
Q
I
E
E
Q
Q
LA
N
A
-----
K
D
R
K
E
Q--VGSGD
R
S
E
R
I
R
TYN------Y
P
--
Q
N
R
L
SEH
R
I
N
L
T
L
Y
S
L
E
---
E
I
M
LSG
N
--
L
D
E
V
I
N
P
L
I
A
H
A
QSQFE--------------------------------------------------------------------------------
1
PsiBlast_PDB
89.57
52%
-67
- C3 -
2B3T
-
RF1_ECOLI
B:
[7-350]
-------------------------
A
-
K
L
E
A
L
H
-
E
R
H
-
E
E
V
--
Q
---
A
L
L
G
D
A
Q
------------------------
T
I
A
D
Q
-
E
R
F
-------------
R
A
L
S
R
E
Y
A
Q
L
S
D
V
S
R
C
---
F
T
D
W
Q
Q
V
-------------------------------------------------
Q
Q
L
Q
V
L
L
L
P
K
--
D
P
--
D
D
E
R
N
A
F
L
E
V
R
-----
A
G
T
-
G
G
D
E
-------
A
A
L
F
A
G
D
L
F
R
M
Y
S
R
Y
--------
A
E
A
R
---
R
W
R
V
E
--
I
M
S
A
S
E
G
E
H
G
----
G
Y
K
E
I
I
-----
A
K
I
S
G
D
G
V
Y
--
G
--------------
R
L
K
F
E
S
G
G
H
R
V
Q
R
V
---
P
A
T
E
S
Q
G
R
I
H
T
S
A
C
T
V
A
V
M
---------
P
E
L
P
-
D
-
A
-
E
L
P
D
V
N
P
------
A
D
L
R
I
D
---
T
F
------
R
S
S
G
A
-
G
G
Q
H
V
----
N
T
T
----
D
S
A
I
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
E
C
Q
D
E
R
S
-----------
Q
H
K
N
K
A
K
A
L
S
V
L
G
A
R
----
I
H
A
-----
A
E
M
A
K
R
Q
-----------
R
R
N
---------
S
D
R
N
R
T
Y
N
------
F
P
--
Q
G
R
V
T
D
H
R
I
N
L
T
L
Y
R
L
D
---
E
V
M
-
E
G
K
--
L
D
M
L
I
E
P
I
I
Q
E
H
Q
A
D
Q
L
--------------------------------------------------------------------------------
17
HHSearch
88.33
51%
-64
- C3 -
2B3T
-
RF1_ECOLI
B:
[7-352]
--------------------------
A
K
L
E
A
L
H
-
E
R
H
-
E
E
V
--
Q
---
A
L
L
G
D
A
Q
------------------------
T
I
A
D
Q
-
E
R
F
-------------
R
A
L
S
R
E
Y
A
Q
L
S
D
V
S
R
C
---
F
T
D
W
Q
Q
V
-------------------------------------------------
Q
Q
L
Q
V
L
L
L
P
K
--
D
P
--
D
D
E
R
N
A
F
L
E
V
R
-----
A
G
T
-
G
G
D
E
-------
A
A
L
F
A
G
D
L
F
R
M
Y
S
R
Y
--------
A
E
A
R
---
R
W
R
V
E
--
I
M
S
A
S
E
G
E
H
G
----
G
Y
K
E
I
I
-----
A
K
I
S
G
D
G
V
Y
--
G
--------------
R
L
K
F
E
S
G
G
H
R
V
Q
R
V
---
P
A
T
E
S
Q
G
R
I
H
T
S
A
C
T
V
A
V
M
---------
P
E
L
P
-
D
-
A
E
L
P
D
-
V
N
P
------
A
D
L
R
I
D
---
T
F
------
R
S
S
G
A
-
G
G
Q
H
V
----
N
T
T
----
D
S
A
I
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
E
C
Q
D
E
R
S
-----------
Q
H
K
N
K
A
K
A
L
S
V
L
G
A
R
----
I
H
A
-----
A
E
M
A
K
R
Q
-----------
R
R
N
---------
S
D
R
N
R
T
Y
N
------
F
P
--
Q
G
R
V
T
D
H
R
I
N
L
T
L
Y
R
L
D
---
E
V
M
E
G
-
K
--
L
D
M
L
I
E
P
I
I
Q
E
H
Q
A
D
Q
L
--------------------------------------------------------------------------------
21
HHSearch
80.02
46%
-47
- C3 -
1RQ0
-
RF1_THEMA
A:
[1-328]
-------------------------------
M
K
-
E
K
K
-
K
E
I
--
E
---
K
L
L
A
R
P
D
------------------------
L
T
P
E
---
Q
M
-------------
K
N
Y
G
M
E
Y
A
K
I
E
E
I
E
N
I
---
T
N
R
I
K
E
T
Q
----
E
F
I
E
L
L
-----
R
E
E
---
G
E
N
E
--
L
E
I
E
K
-
Y
E
K
E
------
L
D
Q
L
Y
Q
E
L
L
F
L
L
S
-----
P
--
E
A
S
D
K
A
I
V
E
I
R
-----
P
G
T
-
G
G
E
E
-------
A
A
L
F
A
R
D
L
F
R
M
Y
T
R
Y
--------
A
E
R
K
---
G
W
N
L
E
--
V
A
E
I
H
E
T
D
L
G
----
G
I
R
E
V
V
-----
F
F
V
K
G
K
N
A
Y
--
G
--------------
I
L
K
Y
E
S
G
V
H
R
V
Q
R
V
---
P
V
T
E
S
G
G
R
I
H
T
S
T
A
T
V
A
V
L
---------
P
E
I
E
-
E
-
K
-
D
I
E
-
I
R
P
------
E
D
L
K
I
E
---
T
F
------
R
A
S
G
-----
Y
V
----
N
K
T
----
E
S
A
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
S
C
Q
N
E
R
S
-----------
Q
Y
Q
N
K
Q
T
A
L
R
I
L
R
A
R
----
L
Y
Q
-----
L
Q
K
E
Q
K
E
R
E
I
S
-----
Q
------------
R
S
E
K
I
R
T
Y
N
------
F
P
--
Q
N
R
V
T
D
H
R
I
N
Y
T
S
Y
R
L
Q
---
E
I
L
D
G
-
D
--
L
D
E
I
I
S
K
L
I
E
H
D
I
E
N
N
L
--------------------------------------------------------------------------------
2
PsiBlast_PDB
78.55
54%
-58
- C3 -
1RQ0
-
RF1_THEMA
A:
[68-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
D
Q
L
Y
Q
E
L
L
F
L
L
--
S
P
--
E
A
S
D
K
A
I
V
E
I
R
-----
P
G
T
-
G
G
E
E
-------
A
A
L
F
A
R
D
L
F
R
M
Y
T
R
Y
--------
A
E
R
K
---
G
W
N
L
E
--
V
A
E
I
H
E
T
D
L
G
----
G
I
R
E
V
V
-----
F
F
V
K
G
K
N
A
Y
--
G
--------------
I
L
K
Y
E
S
G
V
H
R
V
Q
R
V
---
P
V
T
E
S
G
G
R
I
H
T
S
T
A
T
V
A
V
L
---------
P
E
I
E
-
E
-
K
-
D
I
E
-
I
R
P
------
E
D
L
K
I
E
---
T
F
------
R
A
S
G
-----
Y
V
----
N
K
T
----
E
S
A
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
S
C
Q
N
E
R
S
-----------
Q
Y
Q
N
K
Q
T
A
L
R
I
L
R
A
R
----
L
Y
Q
-----
L
Q
K
E
Q
K
E
R
E
I
S
-----
Q
------------
R
S
E
K
I
R
T
Y
N
------
F
P
--
Q
N
R
V
T
D
H
R
I
N
Y
T
S
Y
R
L
Q
---
E
I
-
L
D
G
D
--
L
D
E
I
I
S
K
L
I
E
H
D
I
E
N
N
L
--------------------------------------------------------------------------------
18
HHSearch
64.57
51%
36
- C3 -
1ZBT
-
RF1_STRMU
A:
[4-353]
-------------------------
Y
D
Q
L
Q
A
V
E
-
D
R
Y
-
E
E
L
---------------------------------------------------------------
R
E
E
A
N
S
R
E
T
V
A
V
---
Y
R
E
Y
K
Q
V
V
Q
N
I
A
D
A
Q
E
M
--------
P
E
L
E
E
M
A
K
--
E
E
L
K
N
-
S
K
V
A
------
K
E
E
Y
E
E
K
L
R
F
L
L
L
P
K
--
D
P
--
N
D
D
K
N
I
I
L
E
I
R
-----
G
A
A
-
G
G
D
E
-------
A
A
L
F
A
G
D
L
L
N
M
Y
Q
K
Y
--------
A
E
N
Q
---
G
W
K
F
E
--
V
M
E
A
S
A
N
G
V
G
----
G
L
K
E
V
V
-----
A
M
V
S
G
Q
S
V
Y
--
S
--------------
K
L
K
Y
E
S
G
A
H
R
V
Q
R
V
---
P
V
T
E
S
Q
G
R
V
H
T
S
T
A
T
V
L
V
M
---------
P
E
V
E
-
E
-
V
-
E
Y
E
-
I
D
P
------
K
D
L
R
V
D
---
I
Y
------
H
A
--------------
K
V
----
A
T
A
V
R
I
--------------------
I
---------------------
H
------
L
-----
P
-----------------
T
---
N
-
I
K
V
E
M
Q
E
E
R
T
-----------
Q
Q
K
N
R
D
K
A
M
K
I
I
R
A
R
----
V
A
D
-----
H
F
A
Q
I
A
Q
D
E
Q
D
-----
A
----
T
--
V
G
T
G
D
R
S
E
R
I
R
T
Y
N
------
F
P
--
Q
N
R
V
T
D
H
R
I
G
L
T
L
Q
K
L
D
---
S
I
L
S
G
-
K
--
L
D
E
V
I
D
A
L
I
L
Y
D
Q
T
Q
K
L
--------------------------------------------------------------------------------
20
HHSearch
59.80
34%
33
- C3 -
1GQE
-
RF2_ECOLI
A:
[25-363]
--------------------------
L
D
Y
D
A
K
K
-
E
R
L
-
E
E
V
--
N
---
A
E
L
E
Q
P
D
------------------------
V
W
N
E
P
-
E
R
A
-------------
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
---
L
D
Q
M
K
Q
G
L
E
D
V
S
G
L
L
E
L
A
V
E
A
--
D
D
E
E
T
F
N
E
A
V
--
A
E
L
D
A
-
L
E
E
K
------
L
A
Q
L
E
F
R
----
R
M
F
S
--
G
E
--
Y
D
S
A
D
C
Y
L
D
I
Q
-----
A
G
S
-
G
G
T
E
-------
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
--------
A
E
S
R
---
G
F
K
T
E
--
I
I
E
E
S
E
G
E
V
A
----
G
I
K
S
V
T
-----
I
K
I
S
G
D
Y
A
Y
--
G
--------------
W
L
R
T
E
T
G
V
H
R
L
V
R
K
---
S
P
F
D
S
G
G
R
R
H
T
S
F
S
S
A
F
V
Y
---------
P
E
V
D
D
D
-
I
-
D
I
E
-
I
N
P
------
A
D
L
R
I
D
---
V
Y
------
R
A
S
G
A
-
G
G
Q
H
V
----
N
R
T
----
E
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
-----------
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
----
L
Y
E
-----
V
E
M
Q
K
K
N
A
E
K
Q
-----
A
M
E
D
-
N
--
K
S
D
I
G
W
G
S
Q
I
R
S
Y
V
------
L
D
--
D
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
---
A
V
L
D
G
-
S
--
L
D
Q
F
I
E
A
S
L
K
A
G
L
------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.29
36%
31
- C3 -
1GQE
-
RF2_ECOLI
A:
[32-357]
----------------------------------
E
R
L
-
E
E
V
--
N
---
A
E
L
E
Q
P
D
------------------------
V
W
N
E
P
-
E
R
A
-------------
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
L
D
Q
M
K
Q
G
L
E
D
V
S
G
L
L
E
L
A
V
E
A
-----
D
D
E
E
T
F
N
E
A
V
--
A
E
L
D
A
-
L
E
E
K
------
L
A
Q
L
E
--
F
R
R
M
F
S
G
E
------
Y
D
S
A
D
C
Y
L
D
I
Q
-----
A
G
S
-
G
G
T
E
-------
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
--------
A
E
S
R
---
G
F
K
T
E
--
I
I
E
E
S
E
G
E
V
A
----
G
I
K
S
V
T
-----
I
K
I
S
G
D
Y
A
Y
--
G
--------------
W
L
R
T
E
T
G
V
H
R
L
V
R
K
---
S
P
F
D
S
G
G
R
R
H
T
S
F
S
S
A
F
V
Y
---------
P
E
V
D
-
D
D
I
-
D
I
E
-
I
N
P
------
A
D
L
R
I
D
---
V
Y
------
R
A
S
G
A
-
G
G
Q
H
V
----
N
R
T
----
E
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
-----------
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
----
L
Y
E
-----
V
---
E
M
Q
K
K
N
A
E
K
Q
AM
E
D
N
K
S
D
--
I
G
W
G
---
S
Q
I
R
S
Y
V
------
L
D
--
D
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
---
A
V
-
L
D
G
S
--
L
D
Q
F
I
E
A
S
L
K
A
G
L
------------------------------------------------------------------------------------
3
PsiBlast_PDB
49.68
54%
149
- C- -
2FVO
-
RF1_THEMA
A:
[68-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
D
Q
L
Y
Q
E
L
L
F
L
L
--
S
P
--
E
A
S
D
K
A
I
V
E
I
R
-----
P
G
T
-
G
G
E
E
-------
A
A
L
F
A
R
D
L
F
R
M
Y
T
R
Y
--------
A
E
R
K
---
G
W
N
L
E
--
V
A
E
I
H
E
T
D
L
G
----
G
I
R
E
V
V
-----
F
F
V
K
G
K
N
A
Y
--
G
--------------
I
L
K
Y
E
S
G
V
H
R
V
Q
R
V
---
P
V
T
E
S
G
G
R
I
H
T
S
T
A
T
V
A
V
L
---------
P
E
I
E
-
E
-
K
-
D
I
E
-
I
R
P
------
E
D
L
K
I
E
---
T
F
------
R
A
S
G
------------------
E
S
A
V
R
I
--------------------
T
---------------------
H
------
L
-----
P
-----------------
T
---
G
-
I
V
V
S
C
Q
N
E
R
S
-----------
Q
Y
Q
N
K
Q
T
A
L
R
I
L
R
A
R
----
L
Y
Q
-----
L
Q
K
E
Q
K
E
R
E
I
S
-----
Q
------------
R
S
E
K
I
R
T
Y
N
------
F
P
--
Q
N
R
V
T
D
H
R
I
N
Y
T
S
Y
R
L
Q
---
E
I
-
L
D
G
D
--
L
D
E
I
I
S
K
L
I
E
H
D
I
E
N
N
L
--------------------------------------------------------------------------------
5
PsiBlast_PDB
46.79
36%
187
- C- -
1ML5
1
RF2_ECOLI
Z:
[32-357]
----------------------------------
E
R
L
-
E
E
V
--
N
---
A
E
L
E
Q
P
D
------------------------
V
W
N
E
P
-
E
R
A
-------------
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
LDQ
M
K
Q
G
L
E
D
V
S
G
L
L
E
L
A
V
E
A
-----
D
D
E
E
T
F
N
E
A
V
--
A
E
L
D
A
-
L
E
E
K
------
L
A
Q
L
E
--
F
R
R
M
F
S
G
E
------
Y
D
S
A
D
C
Y
L
D
I
Q
-----
A
G
S
-
G
G
T
E
-------
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
--------
A
E
S
R
---
G
F
K
T
E
--
I
I
E
E
S
E
G
E
V
A
----
G
I
K
S
V
T
-----
I
K
I
S
G
D
Y
A
Y
--
G
--------------
W
L
R
T
E
T
G
V
H
R
L
V
R
K
---
S
P
F
D
S
G
G
R
R
H
T
S
F
S
S
A
F
V
Y
---------
P
E
V
D
-
D
D
I
-
D
I
E
-
I
N
P
------
A
D
L
R
I
D
---
V
Y
------
R
T
S
G
A
-
G
G
Q
H
V
----
N
R
T
----
E
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
-----------
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
----
L
Y
E
LEMQK
K
N
A
E
K
Q
A
M
--------
E
D
N
K
S
D
--
I
G
W
G
---
S
Q
I
R
S
Y
V
------
L
D
--
D
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
---
A
V
-
L
D
G
S
--
L
D
Q
F
I
E
A
S
L
K
A
G
L
------------------------------------------------------------------------------------
4
PsiBlast_PDB
46.79
36%
187
- C- -
1MI6
-
RF2_ECOLI
A:
[32-357]
----------------------------------
E
R
L
-
E
E
V
--
N
---
A
E
L
E
Q
P
D
------------------------
V
W
N
E
P
-
E
R
A
-------------
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
L
D
Q
M
K
Q
G
L
E
D
V
S
G
L
L
E
L
A
V
E
A
-----
D
D
E
E
T
F
N
E
A
V
--
A
E
L
D
A
-
L
E
E
K
------
L
A
Q
L
E
--
F
R
R
M
F
S
G
E
------
Y
D
S
A
D
C
Y
L
D
I
Q
-----
A
G
S
-
G
G
T
E
-------
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
--------
A
E
S
R
---
G
F
K
T
E
--
I
I
E
E
S
E
G
E
V
A
----
G
I
K
S
V
T
-----
I
K
I
S
G
D
Y
A
Y
--
G
--------------
W
L
R
T
E
T
G
V
H
R
L
V
R
K
---
S
P
F
D
S
G
G
R
R
H
T
S
F
S
S
A
F
V
Y
---------
P
E
V
D
-
D
D
I
-
D
I
E
-
I
N
P
------
A
D
L
R
I
D
---
V
Y
------
R
A
S
G
A
-
G
G
Q
H
V
----
N
R
T
----
E
S
A
V
R
I
--------------------
T
---------------------
H
------
I
-----
P
-----------------
T
---
G
-
I
V
T
Q
C
Q
N
D
R
S
-----------
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
----
L
Y
E
V
E
M
Q
K
K
N
A
E
K
Q
A
M
--------
E
D
N
K
S
D
--
I
G
W
G
---
S
Q
I
R
S
Y
V
------
L
D
--
D
S
R
I
K
D
L
R
T
G
V
E
T
R
N
T
Q
---
A
V
-
L
D
G
S
--
L
D
Q
F
I
E
A
S
L
K
A
G
L
------------------------------------------------------------------------------------
23
HHSearch
43.71
28%
-23
- C3 -
2JVA
-
?
A:
[7-101]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
H
-
L
P
D
------
A
E
I
E
L
T
---
A
I
------
R
A
Q
G
A
-
G
G
Q
N
V
----
N
K
V
----
S
S
A
M
H
L
--------------------
R
---------------------
F
DINASS
L
-----
P
P
F
Y
K
E
R
L
L
A
LNDSRITS
D
---
G
V
I
V
L
K
A
Q
Q
Y
R
T
-----------
Q
E
Q
N
R
A
D
A
L
L
R
L
S
E
L
----
I
V
N
-----
A
A
K
L
E
H
H
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
41.34
39%
-32
- C3 -
2JY9
-
?
A:
[7-102]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
-
I
A
D
------
N
E
L
E
I
T
---
A
I
------
R
A
Q
G
A
-
G
G
Q
H
V
----
N
K
T
----
S
S
A
I
H
L
--------------------
R
F
D
IRA
S
G
L
P
E
Y
Y
K
Q
R
L
L
T
ASH
H
------
L
-----
I
-----------------
S
DDG
V
-
I
I
I
K
A
Q
E
F
R
S
-----------
Q
E
L
N
R
E
A
A
I
A
R
L
V
A
V
----
I
K
E
-----
L
T
A
E
Q
K
S
R
R
A
T
-----
R
P
T
R
A
S
--
K
E
R
R
L
S
S
K
A
Q
K
S
S
V
------
K
A
--
L
R
G
K
V
R
R
P
L
D
L
E
H
H
H
H
H
---
H
---------------------------------------------------------------------------------------------------------
30
Fugue
41.25
20%
7
- C3 -
4TWA
11
SYP_PLAF7
A:
[3-497]
---------------------
M
A
I
T
S
K
K
I
E
N
F
S
-
D
W
Y
-
T
Q
V
--
I
---
V
K
S
E
L
I
E
Y
Y
DISGCYILR
P
A
A
Y
Y
I
W
E
C
V
Q
A
F
F
N
K
E
I
-
K
K
L
N
V
E
N
S
Y
F
PLFVTK
N
K
L
E
K
E
K
N
H
I
E
G
F
S
-
P
---
E
V
A
W
V
T
K
Y
G
D
S
N
L
P
E
E
I
A
IRPTS
E
T
I
M
Y
S
V
F
P
K
WI
R
S
Y
R
D
-
L
P
L
K
------
L
N
Q
W
N
T
V
V
R
W
E
F
K
Q
P
--
T
P
FI
R
T
R
E
F
L
W
Q
E
G
H
-----
T
A
H
K
N
E
E
E
-------
A
V
K
L
V
F
D
I
L
D
L
Y
R
R
W
--------
Y
E
E
Y
LA
V
P
I
I
K
G
--
I
K
S
E
G
E
K
F
G
G
AN
F
T
S
T
A
E
A
F
-----
I
S
E
N
G
R
A
I
Q
--
A
A
T
S
H
YLGT
N
F
A
K
M
F
K
I
E
F
E
D
E
N
E
V
K
Q
Y
V
---
H
Q
T
S
W
G
C
T
T
R
S
I
G
I
M
I
M
T
H
GDDKGLVLP
P
N
V
S
-
K
-
Y
-
K
V
V
-
I
V
P
I
F
Y
K
TT
D
E
N
A
I
H
---
S
Y
C
K
D
I
E
K
I
L
K
N
A
-
Q
I
N
C
V
Y
D
DR
A
S
Y
----
S
P
G
Y
K
F
--------------------
N
---------------------
H
W
E
L
R
G-
I
-----
P
-----------------
I
---
R
-
I
E
V
G
P
K
D
L
Q
N
N
S
C
V
I
V
R
RDNN
E
K
C
N
V
K
K
E
S
V
L
L
E
T
Q
----
Q
M
L
-----
V
D
I
H
K
N
L
F
L
K
A
-----
K
K
K
L
D
D
S
I
V
Q
V
T
S
F
S
E
V
M
N
A
L
N
K
K
K
M
V
L
A
P
W
C
E
D
I
A
T
E
E
E
I
K
K
E
T
Q
R
L
S
----
L
T
L
S
G
A
--
M
K
P
L
C
I
P
L
D
Q
P
P
M
P
P
N
M
KCFWSGKPAK
R
W
C
L
F
G
R
SY-------------------------------------------------------------
7
PsiBlast_PDB
41.14
30%
-24
- C3 -
2RSM
-
CL065_MOUSE
A:
[43-104]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
E
------
S
E
L
E
E
Q
---
F
V
------
K
G
H
G
P
-
G
G
Q
A
T
----
N
K
T
----
S
N
C
V
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
---
G
-
I
V
V
K
C
H
Q
T
R
S
-----------
V
D
Q
N
R
K
I
A
R
K
V
L
Q
E
K
----
V
D
V
-----
F
Y
N
S
G
P
S
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
39.88
24%
-20
- C3 -
2RSM
-
CL065_MOUSE
A:
[4-110]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
K
W
G
L
R
L
Q
E
K
---
P
A
L
L
F
P
G
-
M
A
A
S
T
V
Q
V
A
G
R
---------
K
D
Y
P
---
A
-
L
L
P
-
L
N
E
------
S
E
L
E
E
Q
---
F
V
------
K
G
H
G
P
-
G
G
Q
A
T
----
N
K
T
----
S
N
C
V
V
L
--------------------
K
---------------------
H
------
V
-----
P
-----------------
S
---
G
-
I
V
V
K
C
H
Q
T
R
S
-----------
V
D
Q
N
R
K
I
A
R
K
V
L
Q
E
K
----
V
D
V
-----
F
Y
N
S
G
P
S
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
38.82
19%
7
- C2 -
4C3X
9
?
A:
[23-530]
DWTSECD
V
L
V
V
G
SG
G
G
A
L
T
G
A
Y
T
A
A
A
Q
G
L
T
T
I
V
L
E
K
T
-
D
R
F
GG
T
---
S
A
Y
S
G
A
S
------------------------
I
W
L
P
G
-
T
Q
V
-------------
Q
E
R
A
G
L
P
D
S
T
E
N
A
R
T
Y
---
L
R
A
L
L
G
D
A
E
S
E
R
Q
D
A
Y
V
E
-----
T
A
P
A
V
V
A
L
L
E
--
Q
N
P
N
I
E
F
E
F
R
A
F
P
D
YY
K
A
E
G
R
M
D
T
G
R
S
I
N
P
L
DL
D
P
--
A
D
I
G
D
L
A
G
K
V
R
PE
L
D
Q
D
R
T
-
G
Q
D
H
APGPMI
G
G
R
A
L
I
G
R
L
L
A
A
V
Q
S
T
GK
A
E
L
R
T
E
S
V
L
T
---
S
L
I
V
E
DG
R
V
V
G
A
E
V
E
S
G
----
G
E
T
Q
R
I
K
A
NR
G
V
L
M
A
A
G
G
I
E
GN
A
--------------
E
M
R
E
Q
A
G
T
P
G
K
A
I
W
SMG
P
F
G
A
N
T
G
D
A
I
S
A
G
I
A
V
G
G
A
---------
T
A
L
L
-
D
---
Q
A
W
-
F
C
P
------
G
V
E
Q
P
D
GSA
A
F
------
M
V
G
V
R
-
G
G
L
V
V
----
D
S
A
----
G
E
R
Y
L
N
--------------------
E
---------------------
S
------
L
-----
P
-----------------
Y
---
D
-
Q
F
G
R
A
M
D
A
H
D
-----------
D
N
G
S
A
V
P
S
F
M
I
F
D
S
R
EGGG
L
P
A
-----
I
C
I
P
N
T
A
P
A
K
H
-----
L
E
A
G
T
W
--
V
G
A
D
T
L
E
E
L
A
A
K
T
G
------
L
P
--
A
D
A
L
R
S
T
V
E
K
F
N
D
A
A
K
L
GVD
E
E
F
H
R
G
E
DP
Y
D
A
F
F
C
P
P
N
G
G
A
N
A
A
L
T
AIENGP
F
Y
A
A
R
I
V
LSDLGTKG
G
L
V
T
D
VNG
R
V
L
R
ADGSAIDG
L
Y
A
A
G
NTSASLSGRFYPGPG
V
P
L
G
T
A
M
V
F
S
Y
R
A
A
Q
D
M
A
K
31
Fugue
38.38
15%
1
- C3 -
3IBP
1
A:
[11-293]
---------------------------
S
V
S
N
A
R
-
E
E
R
M
A
L
R
--
Q
---
E
Q
E
Q
L
Q
S
------------------------
R
I
Q
S
L
M
Q
R
A
-------------
P
V
W
L
A
A
Q
N
S
L
N
Q
L
S
E
Q
---
C
G
E
E
F
T
S
S
Q
D
V
T
E
Y
L
Q
Q
L
-----
L
E
R
E
R
E
--
A
I
--
V
E
R
D
E
-
V
G
A
R
------
K
N
A
V
D
E
E
I
E
R
L
S
Q
P
G
--
G
S
--
E
D
Q
R
L
N
A
L
A
E
R
-----
F
G
--------------
G
V
L
L
S
E
I
Y
D
D
V
--------------------
S
L
E
--
D
A
P
Y
F
S
A
L
Y
G
----
P
S
R
H
A
I
-----
V
V
P
D
L
S
Q
V
T
--
E
--------------
H
L
E
------
G
L
T
D
C
---
P
E
-----------------------------
D
-
L
-
Y
-
L
I
E
-
G
D
P
------
Q
S
F
D
D
S
---
V
F
------
S
V
D
E
L
E
K
A
V
V
V
----
K
I
A
----
D
R
Q
W
R
Y
--------------------
S
---------------------
R
------
F
-----
P
-----------------
E
---
V
-
P
L
F
G
----
R
A
-----------
A
R
E
S
R
I
E
S
L
H
A
E
R
E
V
----
L
S
E
-----
R
F
A
T
L
S
F
D
V
Q
K
-----
T
Q
R
L
H
Q
--
A
F
S
R
F
I
G
S
H
L
A
V
A
F
------
E
S
--
D
P
E
A
E
I
R
Q
L
N
S
R
R
V
E
L
E
---
R
A
L
S
N
-----------------------------------------------------------------------------------------------------
34
Fugue
37.33
16%
19
* C2 *
4B46
1
CETZ1_HALVD
A:
[1-367]
--------------MKLA
M
I
G
F
G
Q
A
G
G
K
V
V
D
K
F
-
V
E
Y
-
D
R
E
--
R
NAG
I
V
R
A
A
V
A
------------------------
V
N
S
A
K
-
A
D
L
-------------
L
G
L
K
N
---------
I
P
---
K
D
Q
R
V
L
I
G
Q
S
R
V
K
G
H
G
V
G
-----
A
D
N
E
L
G
A
E
I
A
--
E
E
-------
D
------
I
D
E
V
Q
G
A
I
D
S
--
I
P
V
--
H
E
--
V
D
A
F
L
V
V
S
G
L
G
-----
G
G
T
-
G
S
G
G
-------
A
P
V
L
A
K
H
L
K
R
I
Y
------------
T
E
P
---
V
Y
G
L
G
--
I
L
P
G
S
D
E
-------
G
G
I
Y
T
L
-----
N
A
A
R
S
F
Q
T
F
--
V
--------------
R
E
V
D
N
L
L
V
F
D
N
D
A
W
---
R
K
T
G
E
S
V
Q
G
G
Y
D
E
I
N
E
E
I
V
---------
N
R
F
G
-
V
-
L
-
F
G
S
-
V
V
D
------
S
S
E
I
I
N
---
T
L
------
A
G
G
G
V
-
S
T
V
G
Y
----
A
S
E
G
VT
A
H
T
T
N
R
I
--------------------
T
---------------------
S
------
L
-----
V
-----------------
R
---
K
-
A
A
L
G
R
L
T
L
P
C
-----------
E
I
E
G
A
E
R
A
L
L
V
L
A
G
------
P
P
-----
E
H
L
N
R
K
G
I
E
R
G
-----
R
K
W
I
E
E
--
Q
T
G
---
S
M
E
V
R
G
G
D
------
Y
P
--
I
P
G
A
E
---------
K
V
A
---
G
V
I
L
L
S
G
--
V
T
N
V
P
R
I
K
E
L
Q
Q
V
A
I
E
A
Q
D------------------------------------------------------------------------------
28
HHSearch
35.77
20%
43
- C3 -
3SJA
-
GET1_YEAST
C:
[2-45]
----------------------
N
E
L
S
K
K
Y
L
A
K
V
-
K
E
R
-
H
E
L
--
K
---
E
F
N
N
S
I
S
------------------------
A
Q
D
N
Y
-
A
K
W
-------------
T
K
N
N
R
K
L
D
S
L
D
K
E
I
N
N
---
L
K
D
E
I
Q
S
E
N
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
33.39
24%
21
- C3 -
1J26
-
ICT1_MOUSE
A:
[14-108]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
Y
-
I
P
L
------
D
R
L
S
I
S
---
Y
C
------
R
S
S
G
P
-
G
G
Q
N
V
----
N
K
V
----
N
S
K
A
E
V
R
F
HLASADWIE
E
P
V
R
Q
K
I
A
L
T
---------------------
H
------
K
NKINK
A
-----------------
G
---
E
-
L
V
L
T
S
E
S
S
R
Y
-----------
Q
F
R
N
L
A
E
C
L
Q
K
I
R
D
M
----
I
A
E
-----
A
S
G
P
S
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------