@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0080: (2015-12-12 )
MRYFLVVFLFLFVGCMKKDFTLKDLSLPQEASSYLASSQNSSHNNQSIDPQALRENLKESYLKAWYSPWLDAKVKSNKKEVFWILKEMNKSTGYGEDLKPNAKAFNDELIKNMDIERYPSTKIKAVVVRNNDVRAVPTNKPYYLSPKGYPFDRFQNSLVFPGTPVLITPFNPDKTYPPLQSSFVYGWIKVSELAYMRDKEIELLTKLKNYDMPIKEKNPLYTDYGEFYPHAKIGELFPLIPQIQNASQIPPKKELKAYGFLKDAKGYAALQSVFLDEKDFFVFPKAFTSEIMAYFINTMLGQKYGWGGLLGNRDCSAFTRDSFANFGILLPRNSYAQSRYANNYVDLSSMKAKEKEDYIIKNATPFGTLIYLKGHIMLYLGERNHQAIVAHSIWSVQTQKHFKTLSHKIGGVVITSLWLAEEHNGAFSKKKLLIDRVLGMSDLKDFVHKTSSPLNAN
Atome Classification :
(20 SA)
........---.10........20....-....30.--.......40........50.......-.--60........70........----80........90---........100........110.......120.......130.-......140....------...150.-......160---...-.....170.........180-...-.....190.------------...-----------...200.....--------...210.--.---..---...220..----.....230--------------------------..--.......240.......250........260.......270.....--..280---------.........290.-...---..-.---300......--------------.310------------.-..------------.....-.320...-....330.-----------......340...-....-350.......360.........370-------------.------.-----......380....-....390--...----.-.-------------....400--------.--......410.......420.....--..430.......440---........450.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
Y
F
L
V
V
F
---
L
F
L
F
V
G
C
MKKDFTLKDL-SL
P
Q
E
A
S
--
S
Y
L
ASSQNSSHNNQSI
D
P
Q
A
L
R
E
N
L
K
-
E
--
S
Y
L
K
A
W
Y
SPWLDAKVKSNK
K
----
E
V
F
W
I
L
K
E
MNKS---TGYGEDLKP-N
A
K
A
F
N
D
E
L
I
K
NMDIERYPST
K
I
K
A
V
V
V
RNN
D
V
-
R
AVPTNK
P
Y
Y
LSP------KGY
P
F
D
R
-FQNSLVFP----GT
P
-
V
L
I
TPF--NPDKTYPPL
Q
S
--S
F
V
-
Y
G
W
I
K
V
S
E
L
------------
A
Y
M
-----------RD
K
E
-
I
E
L
L
T
K
--------LKNYDMP--I---KE---KNPLYT
D
Y
----
G
E
FYPH----------------------------A
K
--
I
G
E
L
F
P
L
I
P
QIQNASQIP-
P
K
K
E
L
K
A
YGFLKDAK
G
Y
A
A
L
Q
S
V
FLDE--KD
F
-----------
F
V
F
P
K
A
F
T
S
E
I
M
A
-
Y
F
I
---
N
T
-
M
---LGQKYGWGG--------------LL--------------G-NR------------DC
S
A
F
-
T
R
DSFAN-
F
G
I
L
LPRN-----------SYA
Q
S
RYANNYV-
D
L
S
S-MKAKEKE
D
Y
I
I--KNATPF
G
T
L
I
Y
--------------L------K-----
G
H
I
M
L
Y
L
G-ERN
H
-
Q
A
I
V
A
----
H
S
I
----
W
-
S
-------------
V
Q
T
Q
K
H
F
--------
K
--
T
L
S
H
KIG
G
V
V
I
T
S
L
W
L
AEEHNGA
F
--
S
K
K
K
L
L
I
D
R
VL
G
M
S
----
D
L
K
D
F
V
H
KTSSPLNAN
7
HHSearch
98.62
29%
-59
- C2 -
3M1U
13
?
A:
[14-431]
--------------------
R
E
G
H
V
A
D
L
D
R
F
P
Q
D
L
R
--
V
Y
A
M
K
A
----
G
A
D
R
Q
L
L
P
F
T
E
Q
A
A
Q
D
-
A
--
R
W
N
R
R
F
F
A
P
W
R
M
T
R
I
S
V
P
V
K
----
D
V
A
A
P
F
G
T
D
G
R
P
---
R
G
Y
A
E
N
L
L
P
-
W
D
V
T
R
W
G
A
L
A
S
G
A
A
L
D
L
Y
P
S
Q
A
W
K
G
I
V
V
S
N
S
A
L
-
R
E
V
P
T
L
R
P
M
F
T
A
P
TRAG--
Q
G
Y
P
F
D
M
-
F
Q
R
T
A
V
W
M
----
G
T
P
-
V
F
V
G
H
A
--
T
A
D
R
A
W
L
Y
V
E
T
--
A
F
A
-
A
G
W
M
P
A
A
D
V
------------
A
R
V
-----------
D
D
A
F
-
M
T
R
Y
E
S
---------
G
S
L
A
A
I
--
L
---
R
D
---
D
T
S
L
N
G
A
D
----
G
T
H
L
A
T
----------------------------
A
H
--
I
G
T
V
L
P
L
S
---------
G
-
R
T
V
L
V
P
V
R
A
P
-
E
G
H
A
V
V
V
P
V
---
L
L
T
S
--
G
E
A
-----------
A
Q
K
P
V
P
L
T
P
G
N
M
A
-
E
L
G
---
N
R
-
M
---
M
G
Q
P
Y
G
W
G
G
--------------
L
Y
--------------
E
-
D
R
------------
D
C
S
S
T
-
L
R
D
L
F
T
P
-
F
G
L
W
L
P
R
N
-----------
S
A
S
Q
A
K
A
G
-
R
Y
V
-
D
I
A
K
-
L
D
A
D
D
K
E
A
R
I
V
--
A
E
G
V
P
F
M
T
L
L
W
--------------
L
------
R
-----
G
H
I
T
L
Y
L
G
-
L
H
E
G
-
Q
A
A
M
F
----
H
N
M
----
W
-
G
-------------
I
R
T
H
R
G
G
--------
V
--
E
G
R
Y
V
L
G
R
A
V
V
T
S
T
R
P
G
L
D
V
P
G
N
D
--
N
-
A
D
G
L
L
G
R
M
Q
G
M
S
----
I
L
P
G
------------
1
PsiBlast_PDB
92.01
31%
-50
- C2 -
3M1U
12
?
A:
[59-403]
--------------------------------------------------------------------------
F
A
P
W
R
M
T
R
I
S
V
P
V
K
----
D
V
A
A
P
F
G
T
D
G
R
P
---
R
G
Y
A
E
N
L
L
P
-
W
D
V
T
R
W
G
A
L
A
S
G
A
A
L
D
L
Y
P
S
Q
A
W
K
G
I
V
V
S
N
S
A
L
-
R
E
V
P
T
L
R
P
M
F
T
A
P
TRAG--
Q
G
Y
P
F
D
M
-
F
Q
R
T
A
V
W
M
----
G
T
P
-
V
F
V
G
H
A
--
T
A
D
R
A
W
L
Y
V
E
T
--
A
F
A
-
A
G
W
M
P
A
A
D
V
------------
A
R
V
-----------
D
D
A
----
F
M
T
R
--------
Y
E
S
G
S
L
A
A
I
L
---
R
D
---
D
T
S
L
N
G
A
D
----
G
T
H
L
A
T
----------------------------
A
H
--
I
G
T
V
L
P
L
----
S
-----
G
-
R
T
V
L
V
P
----
V
R
A
P
E
G
H
A
V
V
V
P
V
L
L
T
S
--
G
E
A
-----------
A
Q
K
P
V
P
L
T
P
G
N
M
A
-
E
L
G
---
N
R
-
M
---
M
G
Q
P
Y
G
W
G
G
--------------
L
Y
--------------
E
-
D
R
------------
D
C
S
S
T
-
L
R
D
L
F
T
P
-
F
G
L
W
L
P
R
N
-----------
S
A
S
Q
A
K
-
A
G
R
Y
V
-
D
I
A
K
-
L
D
A
D
D
K
E
A
R
I
V
--
A
E
G
V
P
F
M
T
L
L
W
--------------
L
------
R
-----
G
H
I
T
L
Y
L
G
-
L
H
E
G
-
Q
A
A
M
F
----
H
N
M
----
W
-
G
-------------
I
R
T
H
R
G
G
--------
V
--
E
G
R
Y
V
L
G
R
A
V
V
T
S
T
R
P
G
L
D
V
P
G
N
D
--
N
A
D
G
L
L
G
R
M
Q
G
M
S
I
----
L
P
G
-------------
11
HHSearch
60.40
30%
-62
- C2 -
3PBI
-
RIPB_MYCTU
A:
[109-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
A
V
E
Y
V
I
-
R
R
A
---
G
S
-
Q
---
M
G
V
P
Y
S
W
G
G
--------------
G
S
LQGPSKGVDSGAN
T
V
-
G
F
------------
D
C
S
G
L
-
V
R
Y
A
F
A
G
-
V
G
V
L
I
P
R
F
-----------
S
G
D
Q
Y
N
A
G
-
R
H
V
-
P
P
A
E
-
A
K
R
G
D
----------------
L
I
F
--------------
Y
------
G
PGGG-
Q
H
V
T
L
Y
L
G
-
N
--
G
-
Q
M
L
E
A
----
S
G
S
----
A
G
K
-------------
V
T
V
S
P
V
R
--------
K
--
A
G
M
T
P
F
V
T
R
I
I
E
Y
-----------------------------------------------
35
Fugue
56.87
19%
-1
- C1 -
2I3O
-
?
D:
[2-516]
F
R
---------------------------
S
R
P
N
A
L
S
QR
S
V
I
A
S
S
S
-------
E
L
A
S
L
A
G
R
D
I
L
K
-
R
GG
N
I
F
D
A
A
L
A
V
S
A
L
C
V
T
Q
N
N
L
C
GLGG
D
L
F
A
L
I
R
D
E
N
G
Q
IDL
N
G
S
G
Q
A
S
R
A
V
S
I
D
Y
Y
E
S
G
L
T
K
I
P
E
R
G
P
Y
A
A
I
T
V
P
G
I
A
G
S
W
D
E
I
F
R
K
F
A
T
D
I
A
D
I
L
E
P
AIRTAS
A
G
F
P
I
T
Q
-
N
Y
S
D
S
I
A
R
----
S
A
P
-
V
I
G
Q
Y
R
--
G
W
S
S
I
F
P
N
G
S
V
--
P
V
A
-
G
E
I
L
K
Q
P
D
L
AESFRLSEEGFR
S
F
Y
-----------
D
G
S
L
-
A
D
I
I
I
A
GLEGTGSP
L
S
D
R
D
L
R
--
V
YRP
L
I
---
G
K
P
V
F
T
D
L
----
D
E
F
R
I
Y
ETSPNSQGITVIEWIRGESHGYDSRTWE
A
K
--
I
E
D
I
F
E
T
E
E
A
Y
D
K
R
R
K
I
T
D
P
S
Y
N
I
A
Q
H
---
D
S
A
N
G
K
G
L
P
K
R
D
H
N
D
I
--
G
D
T
-----------
T
Y
F
S
I
S
D
S
E
G
R
S
V
-
S
I
I
---
Q
S
-
N
---
Y
G
--
F
G
S
G
I
--------------
V
P
--------------
K
-
G
T
------------
G
F
V
L
Q
-
N
R
G
S
Y
F
T
-----
L
Q
R
D
-----------
H
P
N
A
L
P
G
K
R
T
F
H
-
T
L
A
A
---
C
V
E
K
E
H
D
L
Y
--
A
S
L
G
S
G
G
D
I
Q
P
--------------
Q
------
V
-----
Q
Q
I
L
E
I
L
K
D
N
T
D
P
-
Q
A
I
L
D
----
K
P
R
----
W
-
T
EPYTIYEAPGAVY
V
E
S
E
E
L
Y
--------
R
--
N
V
S
K
Q
I
S
G
R
K
V
V
L
R
D
V
S
Q
E
F
G
T
A
Q
--
I
T
T
L
I
R
G
D
V
V
V
G
A
A
----
D
P
R
G
--
D
G
I
A
I
P
Y
S
--
36
Fugue
54.39
14%
-22
- C1 -
4D0L
2
PI4KB_HUMAN
A:
[10-566]
-
S
W
L
L
R
L
F
E
SK
L
F
D
I
S
M
A
I
S
Y
L
Y
N
S
K
E
P
-
G
V
Q
A
Y
I
G
--
N
R
L
F
C
F
R
N
E
D
V
D
F
--
Y
L
P
Q
L
L
N
M
Y
I
H
M
D
--
E
D
V
G
D
A
I
K
P
Y
I
V
H
R
C
R
Q
S
I
N
----
F
S
L
Q
C
A
L
L
L
G
A
Y
---
S
S
R
G
T
K
L
R
K
-
L
I
L
-------
S
R
L
A
P
E
R
E
F
I
K
S
L
M
A
I
G
K
R
L
A
T
L
-
P
T
K
E
Q
K
T
Q
R
L
I
S
E
------
L
S
L
L
N
H
K
-
L
P
A
R
V
W
L
P
TAG
F
D
H
H
-
V
V
R
V
P
H
--
T
Q
A
V
V
L
N
S
K
D
K
--
A
P
Y
-
L
I
Y
V
E
V
L
E
C
------------
E
N
F
DTTSV
P
A
R
I
PE
N
P
S
A
-
V
A
L
K
E
P
--------
W
Q
E
K
V
R
R
--
I
---
R
E
---
G
S
P
------------
Y
G
H
----------------------------
L
P
--
N
W
R
L
L
S
V
I
V
K
C
G
D
D
-----
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
R
V
P
L
W
I
--
K
P
Y
-----------
K
I
L
V
I
S
A
D
S
G
M
I
E
-
P
V
V
---
N
A
-
V
---
S
I
H
Q
V
K
K
Q
S
--------------
Q
L
--------------
S
-
L
L
------------
D
Y
F
L
Q
-
E
H
G
S
Y
T
T
-
E
A
F
L
S
A
Q
R
-----------
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
-
V
K
D
R
H
N
G
N
I
L
L
--
D
A
E
---
G
H
I
I
H
I
DFGFILSSSSAFK
L
------
T
-----
T
E
F
V
D
V
M
G
-
G
L
D
G
-
D
M
F
N
Y
----
Y
K
M
----
L
-
M
-------------
L
Q
G
L
I
A
A
--------
R
--
K
--
H
M
D
K
V
V
Q
I
V
E
I
M
Q
Q
G
S
Q
L
P
C
F
HG
S
S
T
I
R
N
L
K
E
R
F
H
M
S
MT
E
E
Q
L
Q
L
L
V
E
Q
M
V
D
G
S
M
R
S
12
HHSearch
54.26
23%
-63
- C2 -
2K1G
-
MEPS_ECOLI
A:
[40-163]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
S
R
I
M
-
D
Q
Y
---
A
D
-
W
---
K
G
V
R
Y
R
L
G
G
--------------
S
T
K-------------
K
-
G
I
------------
D
C
S
G
F
-
V
Q
R
T
F
R
E
Q
F
G
L
E
L
P
R
S
-----------
T
Y
E
Q
Q
E
M
G
-
K
S
V
-
S
R
S
N
-
L
R
T
G
D
----------------
L
V
L
--------------
F
RAGST-
G
-----
R
H
V
G
I
Y
I
G
-
N
--
N
-
Q
F
V
H
A
----
S
T
S
----
S
-
G
-------------
V
I
I
S
S
M
N
--------
E
P
Y
W
K
K
R
Y
N
E
A
R
R
V
L
S
R
S
L
E
-------------------------------------------
5
PsiBlast_PDB
53.58
30%
-33
- C2 -
3PBI
-
RIPB_MYCTU
A:
[103-207]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
A
N
A
R
Q
A
V
E
-
Y
V
I
R
R
A
G
S
-
Q
---
M
G
V
P
Y
S
W
G
G
G
S
------------
L
Q
--------------
G
-
P
S
KGVDSGAN
T
V
G
F
D
C
S
G
L
-
V
R
Y
A
F
A
G
-
V
G
V
L
I
P
R
F
-----------
S
G
D
Q
Y
N
-
A
G
R
H
V
-
P
P
A
E
-
A
K
---
R
G
D
L
I
F
--
Y
G
--
P
G
G
G
Q
------------------------------
H
V
T
L
Y
L
G
-
N
G
Q
M
-
L
E
A
S
G
----
S
A
G
----
K
-
V
-------------
T
V
S
P
V
R
K
--------
A
--
G
M
T
P
F
V
T
R
I
I
E
Y
------------------------------------------------
34
Fugue
53.30
16%
-22
- C2 -
2EVR
7
?
A:
[25-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------
L
G
E
Y
Q
C
L
--
A
---
D
L
---
N
L
F
D
S
P
E
C
----
T
R
L
A
T
Q
----------------------------
S
A
--
S
G
R
H
L
W
V
T
S
N
H
Q
N
L
A
V
E
V
-
Y
L
C
E
D
D
Y
P
G
W
L
S
L
S
D
F
D
S
L
Q
P
A
T
V
P
Y
Q
A
A
T
F
S
-----------
E
S
E
I
K
K
L
L
A
E
V
I
A
-
F
T
Q
---
K
A
M
Q
---
Q
S
N
Y
Y
L
W
G
G
--------------
T
V
--------------
G
-
P
N
Y-----------
D
C
S
G
L
M
Q
-
A
A
F
A
S
-
V
G
I
W
L
P
R
D
-----------
A
Y
Q
Q
E
G
F
T
Q
P
I
-----
T
-
I
A
E
L
V
A
G
D
L
V
F
F
G
T
S
Q
K
A
T
H
V
G
L
Y
--------------
L
------
A
-----
D
G
Y
Y
I
H
S
S
-
G
K
D
Q
G
R
D
G
I
G
----
I
D
I
----
L
-
S
-------------
E
Q
G
D
A
V
S
--------
L
--
S
Y
Y
Q
Q
L
R
G
A
G
R
V
F
K
S
Y
E
P
Q
R
R
---------------------------------------
13
HHSearch
43.06
16%
-50
- C2 -
3VPI
6
?
A:
[23-118]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
D
Q
C
I
V
-
N
A
C
---
K
N
-
S
---
W
D
K
S
Y
L
A
G
T
--------------
P
---------------
N
-
K
D
------------
N
C
S
G
F
-
V
Q
S
V
A
A
E
-
L
G
V
P
M
P
R
G
N
A
N
A
M
V
D
G
L
E
Q
S
W
T
K
L
A
S
G
-
A
E
--
A
A
Q
K
-
A
A
Q
G
F
----------------
L
V
I
--------------
A
G
L
K
G
RT
Y
-----
G
H
V
A
V
V
I
S
-
G
P
L
Y
-
R
Q
K
Y
P
----
M
C
W
----
C
-
G
-------------
S
I
A
G
A
V
G
--------
Q
--
S
Q
G
L
K
S
V
G
Q
V
W
N
R
T
D
R
D
R
L
N
Y
Y
V
Y
--
S
L
A
S
C
S
L
P
R
A
S
-----------------------
28
HHSearch
39.37
15%
3
- C2 -
1M9S
1
INLB_LISMO
A:
[474-595]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
Q
----
G
K
N
-
M
R
I
L
R
E
A
K
T
P
I
T
T
W
Y
Q
F
S
I
--
G
G
K
V
I
G
W
V
D
T
R
A
L
------------
N
T
F
-----------
Y
K
Q
S
-
M
E
K
P
T
R
--------
L
T
R
Y
V
S
A
--
N
---
K
A
---
G
E
S
Y
Y
K
V
P
VADN
P
V
K
R
G
T
----------------------------
L
A
KY
K
N
Q
K
L
I
V
D
C
Q
A
----
T
I
E
-
G
Q
L
W
Y
R
I
R
T
S
-
S
T
F
I
G
W
T
K
A
A
N
L
R
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
38.50
32%
0
- C2 -
2HBW
3
?
A:
[115-184]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
W
G
G
--------------
T
V
--------------
G
P
N
Y
------------
D
C
S
G
L
-
M
Q
A
A
F
V
S
-
V
G
I
W
L
P
R
D
-----------
A
Y
Q
Q
E
A
F
-----------
T
Q
A
I
T
I
D
E
L
A
P
--
G
D
L
V
F
F
G
T
P
V
K
--------------
A
------
T
------
H
V
G
L
Y
L
G
-
D
G
C
Y
-
I
H
S
S
G
----
K
A
Q
----
G
-
R
-------------
D
G
I
G
I
D
I
--------
L
--
S
E
Q
G
D
V
V
S
R
S
Y
Y
Q
Q
L
R
G
A
G
R
V
V
K
S
--
Y
K
P
Q
R
H
----------------------------
10
HHSearch
37.17
17%
21
- C- -
2HBW
3
?
A:
[15-230]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
---------------------
E
Y
Q
--
C
---
L
A
---
A
L
N
L
Y
D
S
P
ECT-
S
-
L
A
T
Q
----------------------------
A
A
--
V
G
R
H
L
Q
V
T
S
N
--
Q
Q
------
G
A
A
V
E
V
C
L
C
E
D
D
Y
P
G
W
L
S
L
G
D
L
G
L
L
K
--
P
A
T
V
L
Y
Q
A
K
S
F
S
E
S
E
I
K
K
L
L
P
G
A
I
A
F
T
-
Q
K
A
---
M
Q
-
Q
----
S
N
Y
Y
L
W
G
G
--------------
T
V
G-------------
P
-
N
Y
------------
D
C
S
G
L
-
M
Q
A
A
F
V
S
-
V
G
I
W
L
P
R
D
-----------
A
Y
Q
Q
E
A
F
T
-
Q
A
I
-
T
I
D
E
-
L
A
P
G
D
----------------
L
V
F
--------------
F
------
G
T
PVKA
T
H
V
G
L
Y
L
G
-
D
--
G
-
C
Y
I
H
S
----
S
G
K
AQGR
D
-
G
-------------
I
G
I
D
I
L
S
EQGD
V
V
S
R
S
Y
-
Y
-
Q
Q
L
R
G
A
G
R
V
V
K
S
Y
K
P
Q
R
H
----------------------------------------
37
Fugue
36.90
8%
-12
- C1 -
4BQQ
-
?
A:
[26-395]
M
D
T
Y
A
G
A
Y
---
D
R
Q
S
R
E
-------------------------
R
S
A
A
S
P
A
T
Q
R
S
A
N
E
D
K
A
A
D
L
Q
R
-
E
--
V
E
R
D
G
G
R
F
R
F
V
G
H
F
S
E
A
P
G
A
----
E
---------------------
R
P
-
E
F
E
R
I
L
N
E
C
R
A
G
---------
R
L
N
M
I
I
V
Y
D
---------------------------
V
S
R
-
F
-----------
S
R
L
-
K
V
M
D
A
I
--
P
I
V
S
E
L
L
A
L
G
V
--
T
I
V
-
S
T
Q
E
G
V
F
R
Q
------------
G
N
V
-----------
M
D
L
I
-
H
L
I
M
R
L
--------
D
A
S
H
K
E
S
--
S
---
L
K
---
S
A
K
I
L
D
-------
T
K
N
L
Q
----------------------------
R
E
--
L
G
G
Y
----------------
V
G
G
K
A
P
Y
G
F
E
L
V
S
E
T
K
E
I
T
R
---
N
G
R
--
M
V
N
-----------
V
V
I
N
K
L
A
H
S
T
T
-----------------------
P
L
--------------
T
G
--------------
P
-
F
E
------------
F
E
P
D
V
-
I
R
W
W
W
R
E
-
I
K
T
H
K
P
G
S
-----------
I
T
G
L
C
K
R
M
D
A
D
A
-
V
P
T
R
-
G
W
D
P
A
T
V
M
R
I
L
--
R
D
P
R
I
A
G
F
A
A
E
--------------
V
------
I
-----
Y
K
K
K
P
D
G
T
-
P
T
T
K
-
I
E
G
Y
R
I
QRD
P
I
T
----
L
-
R
-------------
P
V
E
L
D
C
G
--------
P
--
I
I
E
P
A
E
W
Y
E
L
Q
A
W
L
D
G
R
G
R
G
K
G
L
S
--
R
G
Q
A
I
L
S
A
M
D
K
L
Y
C
----
E
C
G
A
V
-----------
32
Fugue
35.73
13%
19
- C2 -
4FDY
-
?
A:
[46-340]
----------------------------------------------------------------------------------------------------------------------------------------
G
V
T
V
S
P
E
V
L
A
H
R
P
L
-
I
E
K
Y
G
K
E
Y
G
I
E
D
Y
------
V
S
Y
I
L
A
I
M
Q
V
E
S
G
G
T
A
----
E
D
V
M
Q
S
S
E
S
L
--
G
L
P
P
N
S
L
S
T
E
E
--
S
I
K
-
Q
G
V
K
Y
F
S
E
L
------------
L
T
S
-----------
A
E
Q
Q
G
V
D
I
D
S
V
--------
I
Q
S
Y
N
Y
G
--
G
---
G
F
---
L
N
Y
V
R
S
-
H
----
G
K
K
Y
T
Y
----------------------------
E
L
--
A
E
Q
F
S
K
E
K
S
G
G
Q
K
A
D
Y
P
N
-
P
I
A
I
P
V
N
G
G
W
R
Y
N
Y
G
N
Q
F
Y
V
Q
L
V
S
Q
Y
L
--
T
D
T
-----------
S
P
T
E
F
D
D
E
T
V
Q
V
I
M
D
E
A
---
L
K
-
Y
---
E
G
F
P
Y
V
F
G
G
--------------
A
S
--------------
P
-
T
T
S-----------
F
D
S
G
L
-
I
Q
W
V
Y
D
K
-
A
G
I
S
L
P
R
V
-----------
A
Q
D
Q
Y
D
A
T
Q
E
I
-----
S
M
E
E
A
Q
A
G
D
L
I
F
F
--
H
S
T
Y
N
A
G
T
Y
V
----------------------------
T
H
V
A
I
Y
L
E
-
G
-
N
R
-
F
Y
H
A
G
----
D
P
I
G
---
Y
-
G
-------------
D
L
S
S
R
Y
W
--------
Q
--
D
H
L
I
G
A
R
R
V
I
H
N
------------------------------------------------
15
HHSearch
35.12
10%
6
- C2 -
2HBW
1
?
A:
[17-80]
--------------------------------------------------------------------------------------------------------------------------------------------
E
Y
Q
C
L
A
A
L
N
L
-
Y
D
S
P
E
C
T
S
--------------------
L
A
T
Q
A
A
V
----
G
R
H
-
L
Q
V
T
S
N
--
Q
-
Q
G
A
A
V
E
V
C
L
CE
D
D
Y
-
P
G
W
L
S
L
G
D
L
------------
G
L
L
-----------
K
P
A
T
-
V
L
Y
Q
A
K
--------
S
F
S
E
S
E
I
--
K
---
K
L
---
L
P
G
A
I
A
F
T
----
Q
K
A
M
Q
Q
----------------------------
S
N
--
Y
Y
L
W
G
G
T
V
G
P
N
Y
D
C
S
G
L
M
-
Q
A
A
F
V
S
V
G
I
W
L
P
R
D
A
Y
Q
Q
E
A
F
T
Q
A
I
T
I
--
D
E
L
-----------
A
P
G
D
L
V
F
F
G
T
P
V
K
-
A
T
H
---
V
G
-
L
---
Y
L
G
D
G
C
Y
I
H
--------------
S
S
--------------
G
-
K
A
------------
Q
G
R
D
G
-
I
G
I
D
I
L
S
-
E
Q
G
D
V
V
S
R
-----------
S
Y
Y
Q
Q
L
R
G
A
G
R
V
-
V
K
S
Y
-
K
P
Q
R
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
33.47
27%
-15
- C2 -
2LKT
-
HRSL4_HUMAN
A:
[5-38]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
E
-
P
K
P
G
D
----------------
L
I
E
--------------
I
------
F
RLG
Y
-
E
H
W
A
L
Y
I
G
-
D
--
G
-
Y
V
I
H
L
----
A
P
P
----
S
-
E
-------------
Y
P
G
A
G
S
S
--------
S
--
V
F
S
V
L
S
N
S
A
E
V
K
R
E
R
L
E
D
V
V
G
G
C
C
--
Y
R
V
N
N
S
L
D
H
E
Y
Q
P
R
----
P
V
E
V
I
I
S
S
A
K
E
M
V
G
Q
K
6
PsiBlast_PDB
32.72
29%
0
- C2 -
3I86
-
?
A:
[7-74]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
R
Q
A
I
E
-
Y
V
I
---
K
R
-
M
G
S
Q
M
G
V
P
Y
S
W
G
G
G
S
LDGPSKGVGDGA
N
I
--------------
T
-
G
F
------------
D
C
S
G
L
-
M
R
Y
G
F
A
G
-
V
G
V
L
I
P
R
F
-----------
S
G
D
Q
Y
N
A
G
R
H
I
P
-
Q
D
Q
A
-
R
R
G
D
L
I
F
Y
G
P
G
--
G
S
Q
H
V
T
M
Y
L
G
N
--------------
G
------
Q
-----
M
L
E
A
S
G
S
A
-
G
K
V
T
-
V
S
P
V
R
----
K
P
G
----
M
-
T
-------------
P
F
L
T
R
I
I
--------
E
--
Y
-----------------------------------------------------------
14
HHSearch
31.16
14%
18
- C2 -
1XOV
2
?
A:
[196-324]
-------------------------------------------------------------------------------------------------------------------------------------------
H
S
G
A
V
V
D
S
V
P
M
-
L
S
K
M
D
F
K
S
S
-------------------
P
I
K
M
Y
K
A
----
G
S
S
-
L
L
V
Y
E
H
----
N
K
Y
W
Y
K
A
Y
I
--
N
D
K
-
L
C
Y
I
Y
K
S
F
C
------------
I
S
N
-----------
G
K
K
D
-
A
K
------------
G
R
I
K
V
R
I
--
K
---
S
A
KD
L
R
I
P
V
W
N
N
T
KLN-
S
G
K
I
K
W
----------------------------
Y
S
--
P
G
T
K
L
S
W
Y
D
N
---
K
------
K
G
Y
L
E
L
W
Y
E
-
K
D
G
W
Y
Y
T
A
N
Y
F
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
30.11
10%
12
* C2 *
1GRI
-
GRB2_HUMAN
A:
[16-57]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
F
K
R
----
G
D
I
-
L
K
V
--------
Q
N
W
Y
K
A
E
L
--
N
G
K
-
D
G
F
I
P
K
N
Y
I
------------
E
M
K
-----------
P
H
P
W
-
F
F
G
K
I
P
--------
R
A
K
A
E
E
M
--
L
---
S
K
---
Q
R
H
D
G
A
F
L
----
I
R
E
S
E
S
----------------------------
A
P
--
G
D
F
S
L
S
V
K
F
G
N
D
V
Q
H
F
K
V
-
L
R
D
G
A
G
K
Y
F
L
W
V
V
K
F
N
S
L
N
E
L
V
D
Y
H
R
S
--
T
S
V
-----------
S
R
N
Q
Q
I
F
L
R
D
I
E
Q
-
V
P
Q
---
Q
P
-
T
---
Y
V
Q
A
L
F
D
F
D
--------------
P
Q
--------------
E
-
D
G
------------
E
L
G
F
R
-
R
G
D
F
I
H
V
-
M
D
N
S
D
P
N
W
-----------
W
K
G
A
C
H
G
Q
T
G
M
F
-
P
R
N
Y
-
V
T
P
V
N
R
N
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
28.45
13%
36
- C2 -
1NG2
-
NCF1_HUMAN
A:
[174-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
A
L
S
T
----
G
D
V
-
V
E
V
V
E
K
--
S
-
E
S
G
W
W
F
C
Q
M
--
K
A
K
-
R
G
W
I
P
A
S
F
L
------------
E
P
L
-----------
D
S
P
D
-
E
T
E
D
P
E
----------
P
-
N
Y
A
--
G
---
E
P
---
Y
V
A
I
K
A
Y
T
A
V--
E
G
D
E
V
S
----------------------------
L
L
--
E
G
E
A
V
E
V
I
H
K
--
L
L
------
D
G
W
W
V
I
R
--
K
D
D
V
T
G
Y
F
P
S
M
Y
L
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------