@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0082: (2015-12-12 )
MQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAGSLVKDLKINDLLVATQLVQHDVDLSAFDHPLGFIPESAIFIETSGSLNALAKKIANEQHIALKEGVIASGDQFVHSKERKEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNADEKAGMSFDEFLEKSAHTSAKFLKSMVDEL
Atome Classification :
(67 SA)
.........10........20........30........40........50........60........70........80........90........100.......110...-....120.......130.-....-..140.......150...-----...-----.160.....-..-170.......180.......190.......200.......210.......220---........230
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQKI
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
FGV
D
F
E
EIPLGG
N
V
F
H
KGVYHN
K
E
I
I
V
A
Y
S
KIG
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
DLKI
N
D
L
L
V
A
T
Q
L
V
Q
HDVDLSAFDHPLGFIP-E
S
A
I
F
I
ETSG
S
L
N
A
L
A
K
K
-IANE-Q
H
I
A
L
KEGVIASG
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
EMEGA
S
V
A
F
V
C
Q
KFGV
P
C
C
V
L
R
SISDNADEKAGM
S
F
D
E
F
L
E
K
SAH
T
S
A
K
----
F
L
K
S
M
V
DEL
22
PsiBlast_CBE
97.26
100%
-126
- C1 -
3NM4
4
MQMTN_HELPJ
B:
[2-230]
-
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
-
I
A
N
E
-
Q
H
I
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
-------
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
----
F
L
K
S
M
V
D
E
L
8
PsiBlast_PDB
96.41
95%
-126
- C1 -
4BMX
1
MQMTN_HELPY
A:
[22-251]
V
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
E
S
L
N
A
L
A
K
E
-
V
A
N
E
-
Q
H
I
V
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
-------
S
F
D
A
F
L
E
K
S
A
Q
T
S
A
K
----
F
L
K
S
M
V
D
E
L
2
PsiBlast_PDB
96.27
100%
-117
- C1 -
3NM5
2
MQMTN_HELPJ
A:
[2-230]
-
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
-
I
A
N
E
-
Q
H
I
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
----
F
L
K
S
M
V
D
E
L
21
PsiBlast_CBE
96.17
100%
-117
- C1 -
3NM5
2
MQMTN_HELPJ
B:
[2-230]
-
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
-
I
A
N
E
-
Q
H
I
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
----
F
L
K
S
M
V
D
E
L
1
PsiBlast_PDB
96.09
100%
-117
- C1 -
3NM4
4
MQMTN_HELPJ
A:
[2-230]
-
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
-
I
A
N
E
-
Q
H
I
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
----
F
L
K
S
M
V
D
E
L
6
PsiBlast_PDB
95.68
99%
-120
- C1 -
4P54
2
MQMTN_HELPJ
A:
[3-231]
-
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
-
I
A
N
E
-
Q
H
I
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
N
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
----
F
L
K
S
M
V
D
E
L
3
PsiBlast_PDB
95.66
100%
-116
- C1 -
3NM6
6
MQMTN_HELPJ
B:
[2-230]
-
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
-
I
A
N
E
-
Q
H
I
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
----
F
L
K
S
M
V
D
E
L
4
PsiBlast_PDB
95.54
100%
-117
- C1 -
4FFS
2
MQMTN_HELPJ
A:
[10-239]
M
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
-
I
A
N
E
-
Q
H
I
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
----
F
L
K
S
M
V
D
E
L
7
PsiBlast_PDB
95.04
99%
-119
- C1 -
4OY3
2
MQMTN_HELPJ
A:
[3-231]
-
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
-
I
A
N
E
-
Q
H
I
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
N
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
----
F
L
K
S
M
V
D
E
L
9
PsiBlast_PDB
94.80
95%
-125
- C1 -
4BN0
-
MQMTN_HELPY
A:
[22-251]
V
Q
K
I
G
I
L
G
A
M
R
E
Q
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
E
S
L
N
A
L
A
K
E
-
V
A
N
E
-
Q
H
I
V
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
-------
S
F
D
A
F
L
E
K
S
A
Q
T
S
A
K
----
F
L
K
S
M
V
D
E
L
5
PsiBlast_PDB
94.56
100%
-115
- C1 -
4OJT
2
MQMTN_HELPJ
A:
[3-231]
-
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
-
I
A
N
E
-
Q
H
I
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
----
F
L
K
S
M
V
D
E
L
24
PsiBlast_CBE
94.03
95%
-117
- C1 -
4BMZ
2
MQMTN_HELPY
B:
[22-251]
V
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
E
S
L
N
A
L
A
K
E
-
V
A
N
E
-
Q
H
I
V
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
N
N
A
D
E
E
A
N
M
S
F
D
A
F
L
E
K
S
A
Q
T
S
A
K
----
F
L
K
S
M
V
D
E
L
10
PsiBlast_PDB
93.61
95%
-117
- C1 -
4BMZ
2
MQMTN_HELPY
A:
[22-251]
V
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
E
S
L
N
A
L
A
K
E
-
V
A
N
E
-
Q
H
I
V
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
N
N
A
D
E
E
A
N
M
S
F
D
A
F
L
E
K
S
A
Q
T
S
A
K
----
F
L
K
S
M
V
D
E
L
23
PsiBlast_CBE
93.28
95%
-115
- C1 -
4BMX
2
MQMTN_HELPY
B:
[22-251]
V
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
E
S
L
N
A
L
A
K
E
-
V
A
N
E
-
Q
H
I
V
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
E
A
N
M
S
F
D
A
F
L
E
K
S
A
Q
T
S
A
K
----
F
L
K
S
M
V
D
E
L
11
PsiBlast_PDB
93.18
95%
-121
- C1 -
4BMY
1
MQMTN_HELPY
A:
[22-251]
V
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
V
K
D
L
K
I
N
D
L
L
V
A
I
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
-
E
S
A
I
F
I
E
T
S
E
S
L
N
A
L
A
K
E
-
V
A
N
E
-
Q
H
I
V
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
-----
S
K
E
-----
R
K
E
F
L
V
S
E
F
-
K
A
-
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
A
N
A
D
E
E
-----
D
A
F
L
E
K
S
A
Q
T
S
A
K
----
F
L
K
S
M
V
D
E
L
13
PsiBlast_PDB
77.35
49%
-107
- C1 -
4JOS
5
?
A:
[24-250]
-
K
K
I
A
I
L
G
A
M
E
I
E
I
Q
P
I
L
Q
K
L
E
-
K
Y
E
T
V
E
Y
A
N
N
K
Y
Y
V
A
N
Y
N
G
I
E
L
V
V
A
Y
S
K
I
G
K
V
F
S
S
L
T
A
T
I
M
I
E
H
F
G
V
D
A
L
L
F
T
G
V
A
G
G
L
-
Q
D
L
Q
V
G
D
M
I
A
A
T
A
T
V
Q
H
D
V
D
I
T
A
F
G
Y
P
Y
G
K
I
P
-
I
S
E
V
E
I
A
T
S
A
R
I
L
E
Q
A
K
V
-
I
A
K
E
-
L
N
L
N
L
H
T
G
V
I
A
T
G
D
Q
F
V
H
-----
S
A
E
-----
R
K
D
F
V
V
K
E
F
-
D
A
-
K
A
I
E
M
E
G
A
S
V
N
L
I
C
N
E
M
N
I
P
S
F
I
L
R
S
I
S
D
T
A
D
G
D
A
P
D
N
F
D
E
F
A
K
M
A
A
N
R
S
A
D
----
F
V
M
K
L
V
D
R
I
12
PsiBlast_PDB
74.34
49%
-109
- C1 -
4JWT
5
?
A:
[24-250]
--
K
I
A
I
M
G
A
M
P
E
E
I
S
P
I
L
E
K
I
G
-
S
Y
K
S
T
S
Y
A
G
N
K
Y
Y
E
A
T
Y
Q
G
V
E
L
V
I
A
Y
S
K
I
G
K
V
F
S
A
L
S
A
A
T
M
I
E
H
F
G
A
T
K
L
L
F
S
G
V
A
G
A
I
S
T
N
L
K
V
G
D
L
I
V
A
T
K
L
S
Q
H
D
L
D
I
T
A
F
G
H
P
Y
G
Y
V
P
-
E
G
S
V
F
V
E
A
D
K
D
M
I
E
L
S
K
K
-
V
A
L
E
-
M
G
K
S
V
Q
E
G
I
I
A
T
G
D
Q
F
V
A
-----
N
E
E
-----
R
K
N
W
I
G
T
T
F
-
G
A
-
D
A
L
E
M
E
G
G
S
V
G
V
V
C
N
A
L
N
I
P
F
F
I
L
R
S
I
S
D
A
A
D
M
D
A
S
F
S
F
D
E
F
L
E
S
S
A
K
E
S
A
E
----
F
I
M
K
M
V
D
E
L
73
PsiBlast_CBE
68.55
31%
-104
- C1 -
4G41
1
?
A:
[7-234]
--
K
I
G
I
I
A
A
M
E
E
E
L
S
L
L
L
A
N
L
-
L
D
A
Q
E
H
Q
V
L
S
K
T
Y
Y
T
G
R
F
G
K
H
E
L
I
L
V
Q
S
G
V
G
K
V
M
S
A
M
T
V
A
I
L
V
E
H
F
K
A
Q
A
I
I
N
T
G
S
A
G
A
V
A
S
H
L
A
I
G
D
V
V
V
A
D
R
L
V
Y
H
D
V
D
A
T
A
F
G
Y
A
Y
G
Q
M
A
-
G
Q
P
L
Y
Y
D
C
D
P
Q
F
V
A
I
F
K
Q
-
V
L
K
H
-
E
K
T
N
G
Q
V
G
L
I
A
T
G
D
S
F
V
A
-----
G
Q
D
-----
K
I
D
Q
I
K
T
A
F
S
N
V
-
L
A
V
E
M
E
G
A
A
I
A
Q
A
A
H
T
A
G
K
P
F
I
V
V
R
A
M
S
D
T
A
A
H
D
A
N
I
T
F
D
Q
F
I
I
E
A
G
K
R
S
A
Q
----
I
L
M
T
F
L
E
N
L
14
PsiBlast_PDB
68.37
35%
-101
- C1 -
4GMH
3
MTNN_STAAM
A:
[4-230]
---
I
G
I
I
G
A
M
E
E
E
V
T
-
I
L
K
N
K
L
T
Q
L
S
E
I
S
V
A
H
V
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
A
D
A
T
A
F
G
Y
E
Y
G
Q
I
P
-
Q
M
P
V
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
-
V
V
Q
Q
-
Q
Q
L
T
A
K
V
G
L
I
V
S
G
D
S
F
I
G
-----
S
V
E
-----
Q
R
Q
K
I
K
K
A
F
P
N
A
-
M
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
----
T
V
E
A
L
V
S
Q
L
72
PsiBlast_CBE
68.29
31%
-100
- C1 -
4G41
1
?
B:
[7-234]
--
K
I
G
I
I
A
A
M
E
E
E
L
S
L
L
L
A
N
L
-
L
D
A
Q
E
H
Q
V
L
S
K
T
Y
Y
T
G
R
F
G
K
H
E
L
I
L
V
Q
S
G
V
G
K
V
M
S
A
M
T
V
A
I
L
V
E
H
F
K
A
Q
A
I
I
N
T
G
S
A
G
A
V
A
S
H
L
A
I
G
D
V
V
V
A
D
R
L
V
Y
H
D
V
D
A
T
A
F
G
Y
A
Y
G
Q
M
A
-
G
Q
P
L
Y
Y
D
C
D
P
Q
F
V
A
I
F
K
Q
-
V
L
K
H
-
E
K
T
N
G
Q
V
G
L
I
A
T
G
D
S
F
V
A
-----
G
Q
D
-----
K
I
D
Q
I
K
T
A
F
S
N
V
-
L
A
V
E
M
E
G
A
A
I
A
Q
A
A
H
T
A
G
K
P
F
I
V
V
R
A
M
S
D
T
A
A
H
D
A
N
I
T
F
D
Q
F
I
I
E
A
G
K
R
S
A
Q
----
I
L
M
T
F
L
E
N
L
61
PsiBlast_CBE
67.87
34%
-96
- C1 -
4YML
1
?
A:
[2-229]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
76
HHSearch
67.71
36%
-97
- C1 -
3EEI
2
?
A:
[3-233]
L
K
T
V
A
V
I
G
A
M
E
Q
E
I
E
L
L
R
E
M
M
E
-
N
V
K
A
V
S
F
G
R
F
S
A
Y
E
G
E
L
A
G
K
R
M
V
L
A
L
S
G
I
G
K
V
N
A
A
V
A
T
A
W
I
I
R
E
F
A
A
D
C
V
I
N
T
G
S
A
G
G
L
G
K
G
L
K
V
G
D
V
V
I
G
T
E
T
A
H
H
D
V
D
V
T
A
F
G
Y
A
W
G
Q
V
P
-
Q
L
P
A
R
F
A
S
D
G
I
L
I
E
A
A
K
R
-
A
A
R
T
F
E
G
A
A
V
E
Q
G
L
I
V
S
G
D
R
F
V
H
-----
S
S
E
-----
G
V
A
E
I
R
K
H
F
P
E
V
-
K
A
V
E
M
E
A
A
A
I
A
Q
T
C
H
Q
L
E
T
P
F
V
I
I
R
A
V
S
D
S
A
D
E
K
A
D
I
S
F
D
E
F
L
K
T
A
A
A
N
S
A
K
----
M
V
A
E
I
V
K
S
L
47
PsiBlast_CBE
67.63
34%
-101
- C1 -
4F1W
11
?
A:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
25
PsiBlast_CBE
67.52
36%
-102
- C1 -
3EEI
2
?
B:
[3-233]
L
K
T
V
A
V
I
G
A
M
E
Q
E
I
E
L
L
R
E
M
M
E
-
N
V
K
A
V
S
F
G
R
F
S
A
Y
E
G
E
L
A
G
K
R
M
V
L
A
L
S
G
I
G
K
V
N
A
A
V
A
T
A
W
I
I
R
E
F
A
A
D
C
V
I
N
T
G
S
A
G
G
L
G
K
G
L
K
V
G
D
V
V
I
G
T
E
T
A
H
H
D
V
D
V
T
A
F
G
Y
A
W
G
Q
V
P
-
Q
L
P
A
R
F
A
S
D
G
I
L
I
E
A
A
K
R
-
A
A
R
T
F
E
G
A
A
V
E
Q
G
L
I
V
S
G
D
R
F
V
H
-----
S
S
E
GVAEI
R
K
H
F
--
P
E
V
-
K
---
A
V
E
M
E
A
A
A
I
A
Q
T
C
H
Q
L
E
T
P
F
V
I
I
R
A
V
S
D
S
A
D
E
K
A
D
I
S
F
D
E
F
L
K
T
A
A
A
N
S
A
K
----
M
V
A
E
I
V
K
S
L
17
PsiBlast_PDB
67.33
36%
-98
- C1 -
3EEI
2
?
A:
[3-233]
L
K
T
V
A
V
I
G
A
M
E
Q
E
I
E
L
L
R
E
M
M
E
-
N
V
K
A
V
S
F
G
R
F
S
A
Y
E
G
E
L
A
G
K
R
M
V
L
A
L
S
G
I
G
K
V
N
A
A
V
A
T
A
W
I
I
R
E
F
A
A
D
C
V
I
N
T
G
S
A
G
G
L
G
K
G
L
K
V
G
D
V
V
I
G
T
E
T
A
H
H
D
V
D
V
T
A
F
G
Y
A
W
G
Q
V
P
-
Q
L
P
A
R
F
A
S
D
G
I
L
I
E
A
A
K
R
-
A
A
R
T
F
E
G
A
A
V
E
Q
G
L
I
V
S
G
D
R
F
V
H
-----
S
S
E
G
V
A
E
I
R
K
H
F
--
P
E
V
-
K
---
A
V
E
M
E
A
A
A
I
A
Q
T
C
H
Q
L
E
T
P
F
V
I
I
R
A
V
S
D
S
A
D
E
K
A
D
I
S
F
D
E
F
L
K
T
A
A
A
N
S
A
K
----
M
V
A
E
I
V
K
S
L
75
HHSearch
67.30
34%
-93
* C1 *
3BL6
1
MTNN_STAAM
A:
[1-230]
A
M
M
I
G
I
I
G
A
M
E
E
E
V
T
I
L
K
N
K
L
T
-
Q
L
S
E
I
S
V
A
H
V
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
A
D
A
T
A
F
G
Y
E
Y
G
Q
I
P
-
Q
M
P
V
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
-
V
V
Q
Q
-
Q
Q
L
T
A
K
V
G
L
I
V
S
G
D
S
F
I
G
-----
S
V
E
-----
Q
R
Q
K
I
K
K
A
F
P
N
A
-
M
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
----
T
V
E
A
L
V
S
Q
L
39
PsiBlast_CBE
67.15
34%
-94
- C1 -
4F3K
3
?
A:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
54
PsiBlast_CBE
67.14
34%
-96
- C1 -
1Y6Q
3
MTNN_ECOLI
A:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
70
PsiBlast_CBE
67.00
34%
-96
- C1 -
1Z5O
2
MTNN_ECOLI
B:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
N
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
62
PsiBlast_CBE
66.97
34%
-96
- C1 -
4WKC
2
?
A:
[2-229]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
44
PsiBlast_CBE
66.95
34%
-94
- C1 -
4F2P
4
?
B:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
15
PsiBlast_PDB
66.80
35%
-95
- C1 -
3BL6
1
MTNN_STAAM
A:
[4-230]
---
I
G
I
I
G
A
M
E
E
E
V
T
-
I
L
K
N
K
L
T
Q
L
S
E
I
S
V
A
H
V
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
A
D
A
T
A
F
G
Y
E
Y
G
Q
I
P
-
Q
M
P
V
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
-
V
V
Q
Q
-
Q
Q
L
T
A
K
V
G
L
I
V
S
G
D
S
F
I
G
-----
S
V
E
-----
Q
R
Q
K
I
K
K
A
F
P
N
A
-
M
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
----
T
V
E
A
L
V
S
Q
L
45
PsiBlast_CBE
66.77
34%
-94
- C1 -
4F2P
6
?
A:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
51
PsiBlast_CBE
66.67
34%
-97
- C1 -
1Y6R
2
MTNN_ECOLI
B:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
66
PsiBlast_CBE
66.59
34%
-98
- C1 -
1Z5N
2
MTNN_ECOLI
A:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
Q
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
50
PsiBlast_CBE
66.40
34%
-102
- C1 -
1Z5P
4
MTNN_ECOLI
A:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
42
PsiBlast_CBE
66.36
34%
-91
- C1 -
4F2W
7
?
B:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
71
PsiBlast_CBE
66.28
34%
-95
- C1 -
1Z5O
2
MTNN_ECOLI
A:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
N
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
58
PsiBlast_CBE
66.26
34%
-94
- C1 -
1NC1
1
MTNN_ECOLI
A:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
52
PsiBlast_CBE
65.92
34%
-94
- C1 -
1Y6R
2
MTNN_ECOLI
A:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
37
PsiBlast_CBE
65.85
32%
-94
- C1 -
4G89
3
MTNN_KLEP7
A:
[7-234]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
-
N
R
Q
T
I
T
I
G
G
S
E
I
Y
T
G
Q
L
H
G
V
D
V
A
L
L
K
S
G
I
G
K
V
A
A
A
M
G
A
T
L
L
L
E
R
C
Q
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
E
K
L
V
A
A
A
E
S
-
C
I
K
A
-
L
D
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
E
E
F
L
A
V
A
A
R
Q
S
T
L
----
M
V
E
N
L
V
Q
N
L
48
PsiBlast_CBE
65.84
34%
-94
- C1 -
3DF9
2
MTNN_ECO57
B:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
64
PsiBlast_CBE
65.80
34%
-95
- C1 -
3O4V
5
MTNN_ECOLI
A:
[4-231]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
38
PsiBlast_CBE
65.74
34%
-94
- C1 -
4F3K
4
?
B:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GSVGL
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
53
PsiBlast_CBE
65.70
34%
-95
- C1 -
1Y6Q
3
MTNN_ECOLI
B:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
65
PsiBlast_CBE
65.65
34%
-97
- C1 -
1Z5N
3
MTNN_ECOLI
B:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
Q
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
49
PsiBlast_CBE
65.64
34%
-96
- C1 -
3DF9
2
MTNN_ECO57
A:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
63
PsiBlast_CBE
65.61
34%
-93
- C1 -
3O4V
7
MTNN_ECOLI
B:
[4-231]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
27
PsiBlast_CBE
65.61
32%
-92
- C1 -
4WKB
2
?
B:
[2-230]
--
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
E
-
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
-
L
A
Q
L
-
P
N
T
H
A
V
R
G
L
I
C
T
G
D
A
F
V
C
-----
T
A
E
-----
R
Q
Q
F
I
R
Q
H
F
-
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
----
M
V
L
K
M
V
E
L
L
59
PsiBlast_CBE
65.59
34%
-102
- C1 -
1JYS
1
MTNN_ECOLI
B:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GSVGL
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
----
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
28
PsiBlast_CBE
65.52
31%
-94
- C1 -
4X24
2
?
B:
[2-230]
--
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
E
-
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
P
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
-
L
A
Q
L
-
P
N
T
H
A
V
R
G
L
I
C
T
G
D
A
F
I
C
-----
T
A
E
-----
G
Q
Q
F
I
R
Q
H
F
-
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
----
M
V
L
K
M
V
E
L
L
56
PsiBlast_CBE
65.12
34%
-97
- C1 -
1NC3
1
MTNN_ECOLI
A:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
57
PsiBlast_CBE
65.10
34%
-92
- C1 -
1NC1
1
MTNN_ECOLI
B:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
19
PsiBlast_PDB
65.04
32%
-95
- C1 -
4WKB
2
?
A:
[2-230]
--
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
E
-
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
-
L
A
Q
L
-
P
N
T
H
A
V
R
G
L
I
C
T
G
D
A
F
V
C
-----
T
A
E
-----
R
Q
Q
F
I
R
Q
H
F
-
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
----
M
V
L
K
M
V
E
L
L
43
PsiBlast_CBE
65.00
34%
-92
- C1 -
4F2W
5
?
A:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
46
PsiBlast_CBE
64.98
34%
-93
- C1 -
4F1W
8
?
B:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
40
PsiBlast_CBE
64.95
34%
-93
- C1 -
4F3C
4
?
B:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GSVGL
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
41
PsiBlast_CBE
64.83
34%
-96
- C1 -
4F3C
4
?
A:
[18-245]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
-
N
R
Q
T
I
T
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
-
C
I
R
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
D
A
-
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
----
M
V
E
T
L
V
Q
K
L
60
PsiBlast_CBE
64.43
34%
-99
- C1 -
1JYS
1
MTNN_ECOLI
A:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
----
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
26
PsiBlast_CBE
64.43
32%
-95
- C1 -
3DP9
3
MTNN_VIBCH
C:
[2-230]
--
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
E
-
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
-
L
A
Q
L
-
P
N
T
H
A
V
R
G
L
I
C
T
G
D
A
F
V
C
-----
T
A
E
-----
R
Q
Q
F
I
R
Q
H
F
-
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
----
M
V
L
K
M
V
E
L
L
55
PsiBlast_CBE
64.35
34%
-94
- C1 -
1NC3
1
MTNN_ECOLI
B:
[12-239]
--
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
-
E
N
R
Q
T
I
S
L
G
G
C
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
-
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
-
C
I
A
E
-
L
N
L
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
GS
V
G
L
A
K
I
-----
R
H
N
F
P
-----
Q
A
-
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
----
M
V
E
S
L
V
Q
K
L
20
PsiBlast_PDB
64.29
31%
-91
- C1 -
4X24
3
?
A:
[2-230]
--
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
E
-
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
P
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
-
L
A
Q
L
-
P
N
T
H
A
V
R
G
L
I
C
T
G
D
A
F
I
C
-----
T
A
E
-----
G
Q
Q
F
I
R
Q
H
F
-
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
----
M
V
L
K
M
V
E
L
L
18
PsiBlast_PDB
63.67
32%
-97
- C1 -
3DP9
2
MTNN_VIBCH
A:
[2-230]
--
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
E
-
D
V
Q
E
V
N
Q
A
G
C
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
-
L
A
Q
L
-
P
N
T
H
A
V
R
G
L
I
C
T
G
D
A
F
V
C
-----
T
A
E
-----
R
Q
Q
F
I
R
Q
H
F
-
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
----
M
V
L
K
M
V
E
L
L
67
PsiBlast_CBE
61.48
34%
-91
- C1 -
4QEZ
2
MTNN_BACAN
C:
[2-223]
--
R
I
A
V
I
G
A
M
E
E
E
V
R
-
I
L
R
D
K
L
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
V
D
V
T
A
F
N
Y
E
Y
G
Q
V
P
-
G
M
P
P
G
F
K
A
D
E
A
L
V
A
L
A
E
K
C
M
Q
------
Q
V
V
K
G
M
I
A
T
G
D
S
F
M
S
-----
D
P
N
-----
R
V
A
A
I
R
D
K
F
-
E
N
L
Y
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
----
F
I
V
K
V
L
E
E
L
69
PsiBlast_CBE
61.46
34%
-91
- C1 -
4QEZ
2
MTNN_BACAN
A:
[2-223]
--
R
I
A
V
I
G
A
M
E
E
E
V
R
-
I
L
R
D
K
L
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
V
D
V
T
A
F
N
Y
E
Y
G
Q
V
P
-
G
M
P
P
G
F
K
A
D
E
A
L
V
A
L
A
E
K
C
M
Q
-------
V
V
K
G
M
I
A
T
G
D
S
F
M
S
-----
D
P
N
-----
R
V
A
A
I
R
D
K
F
-
E
N
L
Y
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
----
F
I
V
K
V
L
E
E
L
68
PsiBlast_CBE
61.29
34%
-90
- C1 -
4QEZ
2
MTNN_BACAN
B:
[2-223]
--
R
I
A
V
I
G
A
M
E
E
E
V
R
-
I
L
R
D
K
L
E
Q
A
E
T
E
T
V
A
G
C
E
F
T
K
G
Q
L
A
G
H
E
V
I
L
L
K
S
G
I
G
K
V
N
A
A
M
S
T
T
I
L
L
E
R
Y
K
P
E
K
V
I
N
T
G
S
A
G
G
F
H
H
S
L
N
V
G
D
V
V
I
S
T
E
V
R
H
H
D
V
D
V
T
A
F
N
Y
E
Y
G
Q
V
P
-
G
M
P
P
G
F
K
A
D
E
A
L
V
A
L
A
E
K
C
M
Q
------
Q
V
V
K
G
M
I
A
T
G
D
S
F
M
S
-----
D
P
N
-----
R
V
A
A
I
R
D
K
F
-
E
N
L
Y
A
V
E
M
E
A
A
A
V
A
Q
V
C
H
Q
Y
E
V
P
F
V
I
I
R
A
L
S
D
I
A
G
K
E
S
N
V
S
F
D
Q
F
L
D
Q
A
A
L
H
S
T
N
----
F
I
V
K
V
L
E
E
L
35
PsiBlast_CBE
60.13
31%
-93
- C1 -
3MMS
3
?
A:
[2-229]
--
K
I
G
I
I
A
A
M
P
E
E
L
A
Y
L
V
Q
H
L
D
N
A
Q
E
Q
V
V
L
G
-
N
T
Y
H
T
G
T
I
V
S
H
E
V
V
L
V
E
S
G
I
G
K
V
M
S
A
M
S
V
A
I
L
A
V
H
F
Q
V
D
A
L
I
N
T
G
S
A
G
A
V
A
E
G
I
A
V
G
D
V
V
I
A
D
K
L
A
Y
H
D
V
D
V
T
A
F
G
Y
A
Y
G
Q
M
A
-
Q
Q
P
L
Y
F
E
S
D
K
T
F
V
A
Q
I
Q
E
-
S
L
-----
Q
N
W
H
L
G
L
I
A
T
G
D
S
F
V
A
-----
G
N
D
-----
K
I
E
A
I
K
S
H
F
P
E
V
-
L
A
V
E
M
E
G
A
A
I
A
Q
A
A
H
A
L
N
L
P
V
L
V
I
R
A
M
S
D
N
A
N
H
E
A
N
I
F
F
D
E
F
I
I
E
A
G
R
R
S
A
Q
V
L
L
A
F
L
K
A
L
----