@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0088: (2015-12-12 )
MKTFKKGVILDAKSVGLKALEVLKEVADFDFYEVTSPNQIVERSIEAEIMVLNKVVITQEVLSQLPKLKLICITATGTDNVDIKSAKALGIEVKNVSAYSTESVAQHTLACALSLLGRINDYDRYCKSGEYSQSDIFTHISDIKMGLIKGGQWGVIGLGNIGKRVAKLAQAFGAKVVYFSPKDKKEEYERLSLEELLKTSGIISIHAPLNESTRDLIALKELQSLKDGAILINVGRGGIVNEKDLALILETKDLYYASDVFVKEPFEKDHAFLNPKIQNKLLLTPHIAWAYSDSLKTLVEKTKENIQDFLASQK
Atome Classification :
(20 SA)
.........10......-----..20......-..30..---.--.....40.--......---.--50.--.--......60........70.....----...80........90........100.......110.......120.......130.....----------...140.....--..150.......160.......170.......180-.-----..----..-----.---..-190------.-----.......200.......210.......220.......230.......240.......250....-...---.260......-.270.......280.......290.......300.......310..-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKTFKK
G
V
I
L
D
A
K
S
V
G
L
-----
K
A
L
E
V
L
K
E
V
A-DF
D
F
Y
E---V--T
S
P
N
Q
I
V
E
--
R
SIE
A
E
---
I
--
M
V
L
--
N
--
K
V
V
I
T
Q
E
V
L
S
QLPK
L
K
L
I
C
I
TAT----GTD
N
V
D
IKSA
K
A
L
G
I
E
V
K
NVSAYS
T
E
S
V
A
Q
H
T
L
A
C
A
L
S
L
L
GRI
N
D
Y
D
R
Y
CKSGEY-
S
Q
S
D
I
----------
F
T
H
I
S
D
I
K
M
G
L--IKGG
Q
W
G
V
I
G
L
G
N
I
G
K
R
V
A
K
L
A
Q
A
FG
A
K
V
V
Y
FSP--K-----D
K
----
K
E
-----
E
---
Y
E
-
R
-
L
------
S
-----
L
E
E
L
L
KTS
G
I
I
S
I
HAPLNES
T
R
D
L
I
A
L
K
E
L
Q
SLKD
G
A
I
L
I
NVGRGGIVNEK
D
L
A
L
I
L
ET-KDLY-YAS---DVFVKEPFEK-DHAFLNPKIQN
K
L
L
LTPH
I
A
W
AY
S
D
S
L
K
T
L
V
E
K
T
K
E
N
I
Q
D
F
L
ASQK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
92.20
35%
-116
- C1 -
1WWK
1
?
A:
[4-282]
------
M
K
V
L
V
A
A
P
L
H
E
-----
K
A
I
Q
V
L
K
D
A
G
L
E
V
I
Y
E
E
---
Y
--
P
D
E
D
R
L
V
E
L
V
K
D
V
E
A
----
I
--
I
V
R
--
S
--
K
P
K
V
T
R
R
V
I
E
S
A
P
K
L
K
V
I
A
R
A
G
V
----
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
V
W
-
A
K
K
E
------------------
A
M
G
I
E
-
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
--
Y
-----
P
N
----
E
E
-----
R
---
A
K
-
E
-
V
------
N
G
K
F
V
D
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
--
A
L
V
K
A
L
-
K
E
G
W
-
I
A
G
A
G
L
D
V
F
E
E
E
P
L
P
K
-
D
H
P
L
T
--
K
F
D
N
-
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
91.60
30%
-110
- C1 -
2CUK
-
?
A:
[1-305]
----
M
R
V
L
V
T
R
T
--
L
P
G
-----
K
A
L
D
R
L
R
E
R
G
L
E
V
E
V
H
R
G
L-
F
--
L
P
K
A
E
L
L
K
--
R
V
E
G
A
V
---
G
--
L
I
P
--
T
V-
E
D
R
I
D
A
E
V
M
D
R
A
K
G
L
K
V
I
A
C
Y
S
V
----
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
A
R
D
G
L
W
--
K
A
W
H
PEL-------
L
L
G
------
L
D
--
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
V
V
Y
H
A
R
--
T
-----
P
K
----
P
L
-----
P
---
Y
P
-
F
-
L
------
S
-----
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
G
-
H
L
F
G
-
A
G
L
---
D
V
T
D
P
E
P
L
P
P
-
G
H
P
L
-
Y
--
A
L
P
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
90.06
35%
-117
- C1 -
1WWK
1
?
B:
[4-282]
------
M
K
V
L
V
A
A
P
L
H
E
-----
K
A
I
Q
V
L
K
D
A
G
L
E
V
I
Y
E
E
---
Y
--
P
D
E
D
R
L
V
E
LV
K
D
V
E
A
----
I
--
I
V
R
--
S
--
K
P
K
V
T
R
R
V
I
E
S
A
P
K
L
K
V
I
A
R
A
G
V
----
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
V
W
-
A
K
K
E
------------------
A
M
G
I
E-
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
--
Y
-----
P
N
----
E
E
-----
R
---
A
K
-
E
-
V
------
N
GKFVD
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
--
A
L
V
K
A
L
-
K
E
G
W
-
I
A
G
AGL
D
V
F
E
E
E
P
L
P
K
-
D
H
P
L
T
--
K
F
D
N
-
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
89.25
32%
-104
- C1 -
1WWK
1
?
A:
[4-307]
----
M
K
V
L
V
A
A
P
--
L
H
E
-----
K
A
I
Q
V
L
K
D
A
G
L
E
V
I
Y
E
E
---
Y
--
P
D
E
D
R
L
V
E
--
L
V
K
D
V
E
---
A
--
I
I
V
--
R
S-
K
P
K
V
T
R
R
V
I
E
S
A
P
K
L
K
V
I
A
R
A
G
V
----
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
M
R
E
G
V
W
--
A
K
K
E
----------
A
M
G
------
I
E
--
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
I
L
L
Y
D
P
--
Y
-----
P
N
----
E
E
R
A
K
E
V
N
---
G
K
-
F
-
V
------
D
-----
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
-
A
G
L
---
D
V
F
E
E
E
P
L
P
K
-
D
H
P
L
-
T
--
K
F
D
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
88.47
29%
-103
- C1 -
1YGY
1
SERA_MYCTU
A:
[3-529]
----
S
L
P
V
V
L
I
A
D
K
L
A
P
-----
S
T
V
A
A
L
G
D
Q
V
-
E
V
R
W
V
D
---
G
--
P
D
R
D
K
L
L
A
--
A
V
P
E
A
D
---
A
--
L
L
V
R
-
S
--
A
T
T
V
D
A
E
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
----
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
-
K
R
S
S
F
----------
S
G
T
-------
E
--
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
--
Y
-----
V
S
----
P
A
-----
R
---
A
A
-
Q
-
L
G
I
E
L
L
-
S
-----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
-
G
H
V
R
-
A
A
G
L
--
D
V
F
A
T
E
P
C
T
D
-
S
P
L
F
E
L
A
Q
----
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
VPDAVNVGGGVVNEEV
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
SDELPV
S
L
S
V
Q
V
R
G
ELAAEEV
E
V
L
R
L
S
A
L
R
G
L
F
SAVIEDAVTFVN
A
P
A
L
A
A
E
RG
V
T
A
E
I
C
K
A
SESPNHR
S
V
V
D
V
R
A
V
G
ADG
S
V
V
T
V
S
G
T
L
Y
G
PQLSQKIVQING
R
H
F
D
L
R
AQ
G
I
N
L
I
I
H
Y
V
DRPG
A
L
G
K
I
G
T
L
L
G
T
A
GVNIQ
A
A
Q
L
S
E
D
AEGP
G
A
T
I
L
L
R
L
D
Q
D
V
P
D
D
V
R
T
A
I
A
A
A
VDAY
K
L
E
V
V
D
LS
12
PsiBlast_PDB
85.58
33%
-118
- C1 -
2D0I
-
?
A:
[4-286]
----
K
V
G
V
L
L
K
M
K
R
--------
E
A
L
E
E
L
K
K
Y
A
-
D
V
E
I
I
L
---
Y
--
P
S
G
E
E
L
----
K
G
V
I
G
R
FD
G
I
--
I
V
S
--
P
--
T
T
K
I
T
R
E
V
L
E
N
A
E
R
L
K
V
I
S
C
H
S
A
----
G
Y
D
N
I
D
L
E
E
A
T
K
R
G
I
Y
V
T
K
V
S
G
L
L
S
E
A
V
A
E
F
T
V
G
L
I
I
N
L
M
R
K
I
H
Y
A
D
K
F
I
R
R
G
E
W
E
S
H
A
K
I
----------
W
T
G
F
K
R
I
E
S
----
L
Y
G
K
K
V
G
I
L
G
M
G
A
I
G
K
A
I
A
R
R
L
I
P
F
G
V
K
L
Y
Y
W
S
R
--
H
-----
R
K
VNVE
K
E
-----
L
---
K
A
-
R
Y
M
------
D
-----
I
D
E
L
L
E
K
S
D
I
V
I
L
A
L
P
L
T
R
D
T
Y
H
I
I
N
E
E
R
V
K
K
L
-
E
G
K
Y
L
V
N
I
G
R
G
A
L
V
D
E
K
A
V
T
E
A
I
K
Q
-
G
K
L
K
G
Y
A
T
---
D
V
F
E
K
E
P
V
R
E
-
H
E
L
F
---
K
Y
E
W
E
T
V
L
T
P
H
Y
A
G
L
A
L
E
A
Q
E
D
V
G
F
R
A
V
E
N
L
L
K
V
L
R
G
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
85.07
29%
-105
- C1 -
1YGY
-
SERA_MYCTU
A:
[3-308]
--
S
L
P
V
V
L
I
A
D
K
--
L
A
P
-----
S
T
V
A
A
L
G
D
Q
V
-
E
V
R
W
V
D
---
G
--
P
D
R
D
K
L
L
A
--
A
V
P
E
A
D
---
A
--
L
L
V
--
R
S-
A
T
T
V
D
A
E
V
L
A
A
A
P
K
L
K
I
V
A
R
A
G
V
----
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
L
R
E
H
T
W
--
K
R
S
S
----------
F
S
G
------
T
E
--
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
V
V
A
Y
D
P
--
Y
-----
V
S
----
P
A
R
A
A
Q
L
G
---
I
E
-
L
-
L
------
S
-----
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
-
A
G
L
---
D
V
F
A
T
E
P
C
T
--
D
S
P
L
-
F
--
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
82.64
31%
-97
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[21-337]
---
M
P
L
V
A
L
L
D
G
R
D
-
C
T
-----
V
E
M
P
I
L
K
D
V
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
K
-
V
L
N
E
A
V
---
G
--
A
L
M
--
Y
H-
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
I
I
V
R
I
G
S
----
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
--
V
Q
S
V
E
Q
I
R
E
V
A
---
S
G
A
------
A
R
--
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
--
Y
-----
L
S
----
D
G
V
E
R
A
L
G
---
L
Q
R
V
-
S
------
T
-----
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
-
A
A
L
---
D
V
H
E
S
E
P
F
S
F
S
Q
G
P
L
-
K
--
D
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.34
34%
-106
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[26-315]
--------
L
L
D
G
R
D
C
T
V
-----
E
-
M
P
I
L
K
D
V
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
G
A
L
M
Y
--
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
I
I
V
R
I
G
S
----
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
-
V
Q
S
------------
V
E
Q
I
R
E
V
A
S
G
A
AR
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
YL
S
-----
D
G
----
V
E
-----
R
A
L
G
L
Q
-
R
-
V
------
S
T----
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L
--
D
V
H
E
S
E
P
F
S
F
-
S
Q
G
P
L
--
K
D
A
P
N
L
I
C
T
P
H
A
A
W
-
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
81.54
32%
-105
- C1 -
4LCJ
2
CTBP2_HUMAN
H:
[25-314]
--------
L
L
D
G
R
D
C
T
V
-----
E
-
M
P
I
L
K
D
L
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
GA
M
M
Y
--
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
V
I
V
R
I
G
S
----
G
Y
D
N
V
D
I
K
A
A
G
E
L
G
I
A
V
C
N
I
P
S
A
A
V
E
E
T
A
D
S
T
I
C
H
I
L
N
L
Y
R
R
N
T
W
L
Y
Q
A
L
R
E
G
T
R
-
V
Q
S
------------
V
E
Q
I
R
E
V
A
S
G
A
AR
I
R
G
E
T
L
G
L
I
G
F
G
R
T
G
Q
A
V
A
V
R
A
K
A
F
G
F
S
V
I
F
Y
D
P
YL
Q
-----
D
G
----
I
E
-----
R
SLG
V
Q
-
R
-
V
Y-----
T
-----
L
Q
D
L
L
Y
Q
S
D
C
V
S
L
H
C
N
L
N
E
H
N
H
H
L
I
N
D
F
T
I
K
Q
M
R
Q
G
A
F
L
V
N
A
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L--
D
V
H
E
S
E
P
F
S
F
-
A
Q
G
P
L
--
K
D
A
P
N
L
I
C
T
P
H
T
A
W
-
Y
S
E
Q
A
S
L
E
M
R
E
A
A
A
T
E
I
R
R
A
I
T
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
81.37
32%
-106
- C1 -
4LCJ
2
CTBP2_HUMAN
E:
[25-314]
--------
L
L
D
G
R
D
C
T
V
-----
E
-
M
P
I
L
K
D
L
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
GA
M
M
Y
--
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
V
I
V
R
I
G
S
----
G
Y
D
N
V
D
I
K
A
A
G
E
L
G
I
A
V
C
N
I
P
S
A
A
V
E
E
T
A
D
S
T
I
C
H
I
L
N
L
Y
R
R
N
T
W
L
Y
Q
A
L
R
E
G
T
R
-
V
Q
S
------------
V
E
Q
I
R
E
V
A
S
G
A
AR
I
R
G
E
T
L
G
L
I
G
F
G
R
T
G
Q
A
V
A
V
R
A
K
A
F
G
F
S
V
I
F
Y
D
P
YL
Q
-----
D
G
----
I
E
-----
R
SLG
V
Q
-
R
-
V
Y-----
T
-----
L
Q
D
L
L
Y
Q
S
D
C
V
S
L
H
C
N
L
N
E
H
N
H
H
L
I
N
D
F
T
I
K
Q
M
R
Q
G
A
F
L
V
N
A
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L--
D
V
H
E
S
E
P
F
S
F
-
A
Q
G
P
L
--
K
D
A
P
N
L
I
C
T
P
H
T
A
W
-
Y
S
E
Q
A
S
L
E
M
R
E
A
A
A
T
E
I
R
R
A
I
T
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
80.90
32%
-104
- C1 -
2OME
1
CTBP2_HUMAN
H:
[10-299]
--------
L
L
D
G
R
D
C
T
V
-----
E
-
M
P
I
L
K
D
L
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
GA
M
M
Y
--
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
V
I
V
R
I
G
S
----
G
Y
D
N
V
D
I
K
A
A
G
E
L
G
I
A
V
C
N
I
P
S
A
A
V
E
E
T
A
D
S
T
I
C
H
I
L
N
L
Y
R
R
N
T
W
L
Y
Q
A
L
R
E
G
T
R
-
V
Q
S
------------
V
E
Q
I
R
E
V
A
S
G
A
AR
I
R
G
E
T
L
G
L
I
G
F
G
R
T
G
Q
A
V
A
V
R
A
K
A
F
G
F
S
V
I
F
Y
D
P
YL
Q
-----
D
G
----
I
E
-----
R
SLG
V
Q
-
R
-
V
Y-----
T
-----
L
Q
D
L
L
Y
Q
S
D
C
V
S
L
H
C
N
L
N
E
H
N
H
H
L
I
N
D
F
T
I
K
Q
M
R
Q
G
A
F
L
V
N
A
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L--
D
V
H
E
S
E
P
F
S
F
-
A
Q
G
P
L
--
K
D
A
P
N
L
I
C
T
P
H
T
A
W
-
Y
S
E
Q
A
S
L
E
M
R
E
A
A
A
T
E
I
R
R
A
I
T
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
80.86
31%
-94
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[21-346]
---
M
P
L
V
A
L
L
D
G
R
D
-
C
T
-----
V
E
M
P
I
L
K
D
V
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
--
G
A
L
M
Y
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
I
I
V
R
I
G
S
----
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
-
V
Q
S
V
E
----------
Q
I
R
E
V
A
S
G
A
A
R
--
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
--
Y
-----
L
S
----
D
G
-----
V
---
E
R
-
A
-
L
G
L
Q
R
V
S
T
-----
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L
--
D
V
H
E
S
E
P
F
S
F
-
S
Q
G
P
L
K
D
--
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
PDSLKNCVN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.82
32%
-104
- C1 -
4LCJ
2
CTBP2_HUMAN
D:
[25-314]
--------
L
L
D
G
R
D
C
T
V
-----
E
-
M
P
I
L
K
D
L
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
GA
M
M
Y
--
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
V
I
V
R
I
G
S
----
G
Y
D
N
V
D
I
K
A
A
G
E
L
G
I
A
V
C
N
I
P
S
A
A
V
E
E
T
A
D
S
T
I
C
H
I
L
N
L
Y
R
R
N
T
W
L
Y
Q
A
L
R
E
G
T
R
-
V
Q
S
------------
V
E
Q
I
R
E
V
A
S
G
A
AR
I
R
G
E
T
L
G
L
I
G
F
G
R
T
G
Q
A
V
A
V
R
A
K
A
F
G
F
S
V
I
F
Y
D
P
YL
Q
-----
D
G
----
I
E
-----
R
SLG
V
Q
-
R
-
V
Y-----
T
-----
L
Q
D
L
L
Y
Q
S
D
C
V
S
L
H
C
N
L
N
E
H
N
H
H
L
I
N
D
F
T
I
K
Q
M
R
Q
G
A
F
L
V
N
A
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L--
D
V
H
E
S
E
P
F
S
F
-
A
Q
G
P
L
--
K
D
A
P
N
L
I
C
T
P
H
T
A
W
-
Y
S
E
Q
A
S
L
E
M
R
E
A
A
A
T
E
I
R
R
A
I
T
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
79.95
27%
-107
- C1 -
3GG9
6
?
A:
[2-328]
---
S
L
K
I
A
V
L
D
D
--
Y
Q
D
AVRKL
D
C
F
S
L
L
Q
D
-
H
-
E
V
K
V
F
N
---
N
T
V
K
G
V
G
Q
L
A
A
--
R
V
A
D
V
E
---
A
--
L
V
L
--
I
RE
R
T
R
V
T
R
Q
L
L
D
R
L
P
K
L
K
I
I
S
Q
T
G
R
VSRD
A
G
G
H
I
D
L
E
A
C
T
D
K
G
V
V
V
L
E
G
K
G
S
-
P
V
A
P
A
E
L
T
W
A
L
V
M
A
A
Q
R
R
I
P
Q
Y
V
A
S
L
K
H
G
A
W
--
Q
Q
S
G
LKSTTMPPNF
G
I
G
------
R
V
--
L
K
G
Q
T
L
G
I
F
G
Y
G
K
I
G
Q
L
V
A
G
Y
G
R
A
F
G
M
N
V
L
V
W
G
R
--
E
-----
N
S
----
K
E
R
A
R
A
D
G
---
F
A
V
A
-
E
------
S
-----
K
D
A
L
F
E
Q
S
D
V
L
S
V
H
L
R
L
N
D
E
T
R
S
I
I
T
V
A
D
L
T
R
M
K
P
T
A
L
F
V
N
T
S
R
A
E
L
V
E
E
N
G
M
V
T
A
L
N
R
G
R
P
G
M
-
A
A
I
---
D
V
F
E
T
E
P
I
L
Q
-
G
H
T
L
-
L
--
R
M
E
N
C
I
C
T
P
H
I
G
Y
V
E
R
E
S
Y
E
M
Y
F
G
I
A
F
Q
N
I
L
D
I
L
Q
G
N
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
79.43
28%
-98
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[1-316]
--
M
K
P
K
V
F
I
T
R
E
--
I
P
E
-----
V
G
I
K
M
L
E
D
E
F
-
E
V
E
V
W
G
D
EK
E
--
I
P
R
E
I
L
L
K
--
K
V
K
E
V
D
---
A
--
L
V
T
--
M
L-
S
E
R
I
D
K
E
V
F
E
N
A
P
K
L
R
I
V
A
N
Y
A
V
----
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
V
R
S
G
E
W
--
K
K
R
G
VAWHPKW---
F
L
G
------
Y
D
--
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
I
L
Y
Y
S
R
--
T
-----
R
K
----
E
E
V
E
R
E
L
N
---
A
E
-
F
-
K
------
P
-----
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
-
A
G
L
---
D
V
F
E
E
E
P
Y
Y
--
N
E
E
L
-
F
--
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.25
33%
-100
- C1 -
1HKU
4
CTBP1_RAT
A:
[29-318]
--------
L
L
D
G
R
D
C
T
V
-----
E
-
M
P
I
L
K
D
V
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
GA
L
M
Y
--
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
I
I
V
R
I
G
S
----
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
-
V
Q
S
------------
V
E
Q
I
R
E
V
A
S
G
A
AR
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
--
Y
LSDGI
E
R
----
A
L
-----
G
---
L
Q
-
R
-
V
------
S
T----
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L--
D
V
H
E
S
E
P
F
S
F
-
S
Q
G
P
L
--
K
D
A
P
N
L
I
C
T
P
H
A
A
W
-
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.19
34%
-104
- C1 -
4LCE
2
CTBP1_HUMAN
A:
[26-315]
--------
L
L
D
G
R
D
C
T
V
-----
E
-
M
P
I
L
K
D
V
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
G
A
L
M
Y
--
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
I
I
V
R
I
G
S
----
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
-
V
Q
S
------------
V
E
Q
I
R
E
V
A
S
G
A
AR
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
V
L
F
Y
D
P
YL
S
-----
D
G
----
V
E
-----
R
A
L
G
L
Q
-
R
-
V
------
S
T----
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L
--
D
V
H
E
S
E
P
F
S
F
-
S
Q
G
P
L
--
K
D
A
P
N
L
I
C
T
P
H
A
A
W
-
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
79.13
32%
-104
- C1 -
2OME
1
CTBP2_HUMAN
B:
[10-299]
--------
L
L
D
G
R
D
C
T
V
-----
E
-
M
P
I
L
K
D
L
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
GA
M
M
Y
--
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
V
I
V
R
I
G
S
----
G
Y
D
N
V
D
I
K
A
A
G
E
L
G
I
A
V
C
N
I
P
S
A
A
V
E
E
T
A
D
S
T
I
C
H
I
L
N
L
Y
R
R
N
T
W
L
Y
Q
A
L
R
E
G
T
R
-
V
Q
S
------------
V
E
Q
I
R
E
V
A
S
G
A
AR
I
R
G
E
T
L
G
L
I
G
F
G
R
T
G
Q
A
V
A
V
R
A
K
A
F
G
F
S
V
I
F
Y
D
P
YL
Q
-----
D
G
----
I
E
-----
R
SLG
V
Q
-
R
-
V
Y-----
T
-----
L
Q
D
L
L
Y
Q
S
D
C
V
S
L
H
C
N
L
N
E
H
N
H
H
L
I
N
D
F
T
I
K
Q
M
R
Q
G
A
F
L
V
N
A
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L--
D
V
H
E
S
E
P
F
S
F
-
A
Q
G
P
L
--
K
D
A
P
N
L
I
C
T
P
H
T
A
W
-
Y
S
E
Q
A
S
L
E
M
R
E
A
A
A
T
E
I
R
R
A
I
T
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
79.10
32%
-103
- C1 -
2OME
1
CTBP2_HUMAN
F:
[10-299]
--------
L
L
D
G
R
D
C
T
V
-----
E
-
M
P
I
L
K
D
L
A
-
T
V
A
F
C
D
---
A
--
Q
S
T
Q
E
I
H
E
--
K
V
L
N
E
A
---
V
GA
M
M
Y
--
H
--
T
I
T
L
T
R
E
D
L
E
K
F
K
A
L
R
V
I
V
R
I
G
S
----
G
Y
D
N
V
D
I
K
A
A
G
E
L
G
I
A
V
C
N
I
P
S
A
A
V
E
E
T
A
D
S
T
I
C
H
I
L
N
L
Y
R
R
N
T
W
L
Y
Q
A
L
R
E
G
T
R
-
V
Q
S
------------
V
E
Q
I
R
E
V
A
S
G
A
AR
I
R
G
E
T
L
G
L
I
G
F
G
R
T
G
Q
A
V
A
V
R
A
K
A
F
G
F
S
V
I
F
Y
D
P
YL
Q
-----
D
G
----
I
E
-----
R
SLG
V
Q
-
R
-
V
Y-----
T
-----
L
Q
D
L
L
Y
Q
S
D
C
V
S
L
H
C
N
L
N
E
H
N
H
H
L
I
N
D
F
T
I
K
Q
M
R
Q
G
A
F
L
V
N
A
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
-
G
R
I
R
-
G
A
A
L--
D
V
H
E
S
E
P
F
S
F
-
A
Q
G
P
L
--
K
D
A
P
N
L
I
C
T
P
H
T
A
W
-
Y
S
E
Q
A
S
L
E
M
R
E
A
A
A
T
E
I
R
R
A
I
T
G
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------