@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0094: (2015-12-12 )
MLKVSVITACFNSEKTIEDTILSVLNQTYKNIEYIIIDGASADSTLEIIQKYKDRIACVMSEKDEGIYDAMNKGIKRSSGDIIALLNSDDFYKDEFVVEKVVHEFENKNCDSVYGDLGVVKPDCLEKVVRYYESGEFSPKTLLYGVVPAHPTLFVKKAIYERYGLYKTDYKISADFEMIIRLFVVQKISFSYLKEVLVIMRTGGVSASGFKSLLLRNKENLRACQENGIQANVFSMLLKYPRKIMGLFKRESKGSLKRND
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10.-..-..---...20........--30-.--........40.--..------.-.-----...50---------.--.--.----.....--60----------------------.--------..-----.-------------....70-.......---.---------80........90.-.......----100-......-.110.......120.......----------------------.130..----...---..-------------------..140..-----.....150.......160.......170--.--......180.----...-...-190......-.200.......210........220.......230.......240.......250.......260----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
V
S
V
I
T
ACFN-SE-K
T
---
I
E
D
T
I
L
S
V
L
N
Q
T
Y--K--N--I
E
Y
I
I
IDGASA--
D
S
------
T
-
L
-----
E
I
I
Q
K
---------
Y
--
K
--
D
----
R
I
A
C
V
--MS----------------------E--------KD-----
E
-------------
G
I
Y
D
A
M
-
N
KGIKRS---S---------G
D
I
I
A
L
LNSDDFY-
K
D
E
F
V
V
E
----
K
V
V
-
H
E
F
ENK-
N
C
D
S
V
YGDLGVV
K
-
P
D
C
L
E
K
V
----------------------
V
R
--
Y
Y
----ESG---EF-------------------SP
K
T
L
L
Y
-----
G
VVPAH
P
T
L
F
V
K
K
A
I
Y
E
R
YGLYKT
D
Y
K
I
--S--A
D
F
E
M
I
I
R
L
F
----
V
V
Q
-
K
I
S
-
F
S
Y
L
K
E
V
L
V
-
I
MRTGGV
S
A
S
G
F
K
-
S
L
L
L
RN
K
E
N
L
R
A
C
Q
ENGI
Q
A
N
V
F
S
M
L
L
K
Y
P
R
K
I
M
G
L
F
KRESKGSLKRND------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
77.61
18%
-89
- C2 -
1QG8
2
SPSA_BACSU
A:
[1-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
V
S
V
I
M
T
S
Y
N
-
K
S
-
D
Y
---
V
A
K
S
I
S
S
I
L
S
Q
T
F
--
S
--
D
--
F
E
L
F
I
M
D
D
N
S
N
--
E
E
------
T
-
L
-----
N
V
I
R
P
---------
F
--
L
ND
N
----
R
V
R
F
Y
--
Q
S
----------------------
D
ISG
V
K
E
R
T
E
K
-----
T
-------------
R
Y
A
A
L
I
-
N
Q
A
I
E
M
A
---
E
---------
G
E
Y
I
T
Y
A
T
D
D
N
I
Y
-
M
P
D
R
L
L
K
----
M
V
R
-
E
L
D
T
H
P
-
E
K
A
V
I
Y
S
A
S
K
T
Y
H
L
N
D
I
V
K
E
T
----------------------
V
R
--
P
A
----
A
Q
V
---
T
W
-------------------
N
A
P
C
A
I
D
-----
H
C
S
V
M
H
R
Y
S
V
L
E
K
V
K
E
K
F
G
S
Y
W
D
E
S
P
A
F
YR
I
--
G
D
A
R
F
F
W
R
V
------
N
H
-
F
Y
P
-
F
Y
P
L
D
E
E
L
D
-
L
N
Y
I
T
E
F
V
R
N
L
P
P
-
Q
--------------------------
R
N
C
R
E
L
R
E
S
L
K
K
L
G
M
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
77.29
18%
-86
- C2 -
2Z86
4
CHS_ECOLX
A:
[4-625]
IDID
A
A
T
K
I
M
C
S
N
A
KA
I
S
L
N
E
V
E
K
N
E
I
I
S
K
Y
R
E
I
T
A
K
K
S
E
R
A
E
L
K
EVEPIPLDWPSDLTLPPLPESTND
Y
V
W
A
G
K
RKELLIID
G
L
S
I
V
I
P
T
YNR
A
K
I
L
A
I
T
L
A
C
L
C
N
QKTI
Y
D
Y
E
V
I
V
A
D
DGSKEN
I
E
E
I
V
R
E
F
E
SLLN
I
K
Y
V
R
Q
K
D
YGYQ
L
C
A
V
R
N
L
G
L
R
A
AKYN
Y
V
A
I
L
D
CD
M
A
P
N
PL
W
V
Q
S
Y
M
E
L
L
A
V
DDN
V
A
L
I
G
P
R
K
Y
I
D
TSKHT
Y
L
D
F
L
S
Q
KSLINEIPESVDWR
I
E
H
F
K
N
T
D
NLRLCNTPFRFFSGG
N
V
A
F
A
K
K
W
L
F
R
A
GWFDEEFTHWGG
E
D
N
E
F
G
Y
R
L
Y
R
E
G
C
Y
F
R
S
V
EGA
M
A
Y
H
Q
E
P
PQLLQQKVPYFYRKKEKIESATLKR
V
P
L
V
S
I
Y
I
P
A
Y
N
-
C
S
-
K
Y
---
I
V
R
C
V
E
S
A
L
N
Q
T
I
--
T
--
D
--
L
E
V
C
I
C
D
D
G
S
T
--
D
D
------
T
-
L
-----
R
I
L
Q
E
---------
H
YA
N
--
H
----
P
R
V
R
F
--
I
S
----------------------
Q
--------
K
N
-----
K
-------------
G
I
G
S
A
S
-
N
T
A
V
R
L
C
---
R
---------
G
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
D
A
V
E
L
----
C
L
D
-
E
F
R
K
D
L
-
S
L
A
C
V
Y
T
T
N
R
N
I
D
-
R
E
--
G
N
L
----------------------
I
S
--
N
G
----
Y
N
W
---
P
I
-------------------
Y
S
R
E
K
L
T
-----
S
A
M
I
C
H
H
F
R
M
F
T
A
R
A
W
N
L
T
E
G
F
N
E
S
I
S
N
--
A
--
V
D
Y
D
M
Y
L
K
L
------
S
E
-
V
G
P
-
F
K
H
I
N
K
I
C
Y
-
N
R
V
----------------
L
H
S
I
K
K
L
D
I
Q
K
E
N
H
F
K
V
V
N
E
S
L
S
R
L
G
I
K
K
Y
K
Y
S
P
L
T
N
L
N
E
C
R
K
Y
T
W
E
K
I-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.01
35%
-119
- C2 -
2Z86
2
CHS_ECOLX
A:
[377-479]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
I
P
A
Y
N
-
C
S
-
K
Y
---
I
V
R
C
V
E
S
A
L
N
Q
T
I
--
T
--
D
--
L
E
V
C
I
C
D
D
G
S
T
--
D
D
------
T
-
L
-----
R
I
L
Q
E
---------
H
--
Y
--
A
----
N
H
P
R
V
R
F
I
S
----------------------
Q
--------
K
N
-----
K
-------------
G
I
G
S
A
S
-
N
T
A
V
R
L
C
---
R
---------
G
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
D
-
A
V
E
----
L
C
L
-
D
E
F
R
K
D
-
L
S
L
A
C
V
Y
T
T
N
R
N
I
-
D
R
E
G
N
L
I
----------------------
S
N
--
G
Y
----
N
W
P
---
I
Y
-------------------
S
R
E
K
L
T
S
-----
A
M
I
C
H
H
F
R
M
F
T
A
R
A
W
N
L
T
E
G
F
N
E
S
I
S
N
A
--
V
--
D
Y
D
M
Y
L
K
L
S
E
----
V
G
P
-
F
K
H
-
I
N
K
I
C
Y
N
R
V
-
L
H
S
I
K
K
L
D
I
Q
K
E
N
-
H
F
K
V
V
N
E
S
L
S
R
L
G
I
K
K
Y
K
Y
S
P
L
T
N
L
N
E
C
R
K
Y
T
W
E
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
71.19
17%
-72
- C2 -
1XHB
4
GALT1_MOUSE
A:
[8-466]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N
R
S
L
P
DVRL
E
G
C
K
T
K
V
Y
P
D
N
L
P
T
T
S
V
V
I
V
F
H
N
E
A
W
-
S
T
---
L
L
R
T
V
H
S
V
I
N
R
S
P
--
R
--
H
MI
E
E
I
V
L
V
D
D
A
S
E
--
R
D
------
F
-
L
K
R
P
L
E
S
Y
V
K
K
---------
L
--
K
--
V
----
P
V
H
V
I
--
R
M
----------------------
E
--------
Q
R
-----
S
-------------
G
L
I
R
A
R
-
L
K
G
A
A
V
S
---
R
---------
G
Q
V
I
T
F
L
D
A
H
C
E
C
-
T
A
G
W
-
L
E
----
P
L
L
-
A
R
I
K
H
D
-
R
R
T
V
V
C
P
I
I
D
V
I
S
-
D
D
T
F
E
Y
M
A
G
S
DM
T
Y
G
G
F
N
WKL
N
F
R
W
Y
P
VP
Q
R
--
E
M
----
D
R
R
---
K
G
-------------------
D
R
T
L
P
V
R
-----
T
P
T
M
A
G
G
L
F
S
I
D
R
D
Y
F
Q
E
I
G
T
Y
D
A
G
M
D
I
--
W
GG
E
N
L
E
I
S
F
R
I
W
Q
C
G
G
T
L
E
-
I
V
T
-
C
S
H
V
G
H
V
--------------
F
G
-
Q
I
I
N
K
N
N
R
R
L
A
E
V
W
M
D
E
F
K
N
F
F
Y
I
I
S
P
G
V
T
K
V
D
Y
G
D
I
S
S
R
L
G
L
R
R
K
L
Q
C
KP
F
S
W
Y
L
E
N
IYPDSQIPRHYFSLGEIRNVETN
Q
C
L
D
NMARKEN
E
K
V
G
I
F
NCHGMGGNQVFSYTANKEIRTDD
L
C
L
D
V
S
K
LN
G
P
V
T
M
L
KCHHLKGNQ
L
W
E
Y
D
PVKLTLQHVNSN
Q
C
L
D
K
A
TEEDSQ
V
P
S
I
R
DCTGSRSQQWLLRNV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
70.37
17%
-104
* C2 *
2D7I
5
GLT10_HUMAN
A:
[111-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
N
T
S
I
I
I
P
F
H
N
-
E
G
W
S
S
---
L
L
R
T
V
H
S
V
L
N
R
S
P
--
P
EL
V
--
A
E
I
V
L
V
D
D
F
S
D
--
R
E
------
H
L
K
-----
K
P
L
E
D
---------
Y
--
M
--
A
L
F
P-
S
V
R
I
L
--
R
T
----------------------
K
--------
K
R
-----
E
-------------
G
L
I
R
T
R
-
M
L
G
A
S
V
A
---
T
---------
G
D
V
I
T
F
L
D
S
H
C
E
A
-
N
V
N
-
W
L
P
----
P
L
L
-
D
R
I
A
R
N
-
R
K
T
I
V
C
P
M
I
D
V
I
D
-
H
D
D
F
R
Y
E
----------------------
T
Q
AG
D
A
----
M
R
G
---
A
F
D
WEMY
Y
K
R
I
P
IPPELQKAD
P
S
D
P
-
F
E
-----
S
P
V
M
A
G
G
L
F
A
V
D
R
K
W
F
W
E
L
G
G
Y
D
P
G
L
E
I
WG
G
--
E
Q
Y
E
I
S
F
K
V
W
----
M
-
C
-
G
G
R
-
M
E
D
I
P
C
S
R
V
-
G
H
I
Y
R
K
Y
V
P
Y
K
V
P
-
A
G
V
S
L
A
R
N
L
K
R
V
A
E
V
W
M
D
E
Y
A
E
Y
I
Y
Q
R
R
P
E
Y
R
H
L
S
A
G
D
V
A
V
Q
K
K
L
R
S
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
69.54
35%
-106
- C2 -
2Z87
2
CHS_ECOLX
B:
[376-478]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
I
P
A
Y
N
-
C
S
-
K
Y
---
I
V
R
C
V
E
S
A
L
N
Q
T
I
--
T
--
D
--
L
E
V
C
I
C
D
D
G
S
T
--
D
D
------
T
-
L
-----
R
I
L
Q
E
---------
H
--
Y
--
A
----
N
H
P
R
V
R
F
I
S
----------------------
Q
--------
K
N
-----
K
-------------
G
I
G
S
A
S
-
N
T
A
V
R
L
C
---
R
---------
G
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
D
-
A
V
E
----
L
C
L
-
D
E
F
R
K
D
-
L
S
L
A
C
V
Y
T
T
N
R
N
I
-
D
R
E
G
N
L
I
----------------------
S
N
--
G
Y
----
N
W
P
---
I
Y
-------------------
S
R
E
K
L
T
S
-----
A
M
I
C
H
H
F
R
M
F
T
A
R
A
W
N
L
T
E
G
F
N
E
S
I
S
N
A
--
V
--
D
Y
D
M
Y
L
K
L
S
E
----
V
G
P
-
F
K
H
-
I
N
K
I
C
Y
N
R
V
-
L
H
N
T
S
I
K
K
L
D
I
Q
K
-
E
N
H
F
K
V
V
N
E
S
L
S
R
L
G
I
K
K
Y
K
Y
S
P
L
T
N
L
N
E
C
R
K
Y
T
W
E
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.13
35%
-113
- C2 -
2Z87
2
CHS_ECOLX
A:
[376-478]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
I
P
A
Y
N
-
C
S
-
K
Y
---
I
V
R
C
V
E
S
A
L
N
Q
T
I
--
T
--
D
--
L
E
V
C
I
C
D
D
G
S
T
--
D
D
------
T
-
L
-----
R
I
L
Q
E
---------
H
--
Y
--
A
----
N
H
P
R
V
R
F
I
S
----------------------
Q
--------
K
N
-----
K
-------------
G
I
G
S
A
S
-
N
T
A
V
R
L
C
---
R
---------
G
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
D
-
A
V
E
----
L
C
L
-
D
E
F
R
K
D
-
L
S
L
A
C
V
Y
T
T
N
R
N
I
-
D
R
E
G
N
L
I
----------------------
S
N
--
G
Y
----
N
W
P
---
I
Y
-------------------
S
R
E
K
L
T
S
-----
A
M
I
C
H
H
F
R
M
F
T
A
R
A
W
N
L
T
E
G
F
N
E
S
I
S
N
A
--
V
--
D
Y
D
M
Y
L
K
L
S
E
----
V
G
P
-
F
K
H
-
I
N
K
I
C
Y
N
R
V
-
L
H
S
I
K
K
L
D
I
Q
K
E
N
-
H
F
K
V
V
N
E
S
L
S
R
L
G
I
K
K
Y
K
Y
S
P
L
T
N
L
N
E
C
R
K
Y
T
W
E
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
68.90
15%
-97
- C2 -
3CKJ
5
GPGS_MYCPA
A:
[47-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
T
I
S
V
V
L
P
A
L
D
-
E
E
-
D
T
---
I
G
S
V
I
D
S
I
S
P
L
V
D
--
G
L-
V
--
D
E
L
I
V
L
D
S
G
S
T
--
D
D
------
T
-
E
-----
I
R
A
V
A
---------
A
--
G
--------
A
R
V
V
--
S
R
----------------------
E
QALPE
V
P
-
I
R
-----
P
-------------
G
K
G
E
A
L
-
W
R
S
L
A
A
S
---
R
---------
G
D
I
V
V
F
V
D
S
D
L
I
N
P
H
P
M
-
F
V
P
----
W
L
V
-
G
P
L
L
T
G
D
G
V
H
L
V
K
S
F
Y
R
R
P
--------------------------------
G
--
R
V
T
E
L
V
A
R
P
---
L
L
A
A
L----------------
R
P
E
L
-
G
C
-----
I
L
Q
P
L
G
G
E
Y
A
A
T
R
E
L
L
T
S
V
-
P
F
A
P
G
--
Y
--
G
--
V
E
I
G
L
L
V
D
T
F
----
D
R
L
-
G
L
D
A
I
A
Q
V
N
L
G
V
R
-
E
H
R
N
R
P
L
A
E
L
G
A
M
-
S
R
Q
V
I
A
T
L
L
S
R
C
G
I
P
D
S
G
V
G
L
T
Q
F
V
A
D
G
P
E
G
Q
S
Y
T
Q
H
T
W
P
V
S
L
A
D
R
P
P
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
66.41
35%
-112
- C2 -
2Z86
2
CHS_ECOLX
D:
[377-479]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
I
P
A
Y
N
-
C
S
-
K
Y
---
I
V
R
C
V
E
S
A
L
N
Q
T
I
--
T
--
D
--
L
E
V
C
I
C
D
D
G
S
T
--
D
D
------
T
-
L
-----
R
I
L
Q
E
---------
H
--
Y
--
A
----
N
H
P
R
V
R
F
I
S
----------------------
Q
--------
K
N
-----
K
-------------
G
I
G
S
A
S
-
N
T
A
V
R
L
C
---
R
---------
G
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
D
-
A
V
E
----
L
C
L
-
D
E
F
R
K
D
-
L
S
L
A
C
V
Y
T
T
N
R
N
I
-
D
R
E
G
N
L
I
----------------------
S
N
--
G
Y
----
N
W
P
---
I
Y
-------------------
S
R
E
K
L
T
S
-----
A
M
I
C
H
H
F
R
M
F
T
A
R
A
W
N
L
T
E
G
F
N
E
S
I
S
N
A
--
V
--
D
Y
D
M
Y
L
K
L
S
E
----
V
G
P
-
F
K
H
-
I
N
K
I
C
Y
N
R
V
-
L
H
D
I
Q
K
E
N
H
F
K
V
V
-
N
E
S
L
S
R
L
G
I
K
K
Y
K
Y
S
P
L
T
N
L
N
E
C
R
K
Y
T
W
E
K
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
66.07
35%
-115
- C2 -
2Z86
2
CHS_ECOLX
B:
[377-479]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
I
P
A
Y
N
-
C
S
-
K
Y
---
I
V
R
C
V
E
S
A
L
N
Q
T
I
--
T
--
D
--
L
E
V
C
I
C
D
D
G
S
T
--
D
D
------
T
-
L
-----
R
I
L
Q
E
---------
H
--
Y
--
A
----
N
H
P
R
V
R
F
I
S
----------------------
Q
--------
K
N
-----
K
-------------
G
I
G
S
A
S
-
N
T
A
V
R
L
C
---
R
---------
G
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
D
-
A
V
E
----
L
C
L
-
D
E
F
R
K
D
-
L
S
L
A
C
V
Y
T
T
N
R
N
I
-
D
R
E
G
N
L
I
----------------------
S
N
--
G
Y
----
N
W
P
---
I
Y
-------------------
S
R
E
K
L
T
S
-----
A
M
I
C
H
H
F
R
M
F
T
A
R
A
W
N
L
T
E
G
F
N
E
S
I
S
N
A
--
V
--
D
Y
D
M
Y
L
K
L
S
E
----
V
G
P
-
F
K
H
-
I
N
K
I
C
Y
N
R
V
-
L
H
G
N
T
S
I
K
K
L
D
I
Q
-
K
E
N
H
F
K
V
V
N
E
S
L
S
R
L
G
I
K
K
Y
K
Y
S
P
L
T
N
L
N
E
C
R
K
Y
T
W
E
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
65.97
35%
-114
- C2 -
2Z86
2
CHS_ECOLX
C:
[377-479]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
I
Y
I
P
A
Y
N
-
C
S
-
K
Y
---
I
V
R
C
V
E
S
A
L
N
Q
T
I
--
T
--
D
--
L
E
V
C
I
C
D
D
G
S
T
--
D
D
------
T
-
L
-----
R
I
L
Q
E
---------
H
--
Y
--
A
----
N
H
P
R
V
R
F
I
S
----------------------
Q
--------
K
N
-----
K
-------------
G
I
G
S
A
S
-
N
T
A
V
R
L
C
---
R
---------
G
F
Y
I
G
Q
L
D
S
D
D
F
L
-
E
P
D
-
A
V
E
----
L
C
L
-
D
E
F
R
K
D
-
L
S
L
A
C
V
Y
T
T
N
R
N
I
-
D
R
E
G
N
L
I
----------------------
S
N
--
G
Y
----
N
W
P
---
I
Y
-------------------
S
R
E
K
L
T
S
-----
A
M
I
C
H
H
F
R
M
F
T
A
R
A
W
N
L
T
E
G
F
N
E
S
I
S
N
A
--
V
--
D
Y
D
M
Y
L
K
L
S
E
----
V
G
P
-
F
K
H
-
I
N
K
I
C
Y
N
R
V
-
L
H
G
E
N
T
S
I
K
K
L
D
I
-
Q
K
E
N
H
F
K
V
V
N
E
S
L
S
R
L
G
I
K
K
Y
K
Y
S
P
L
T
N
L
N
E
C
R
K
Y
T
W
E
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
65.28
16%
-50
- C2 -
4HG6
4
?
A:
[13-759]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V
V
P
V
L
L
F
L
L
W
V
A
L
L
V
P
F
G
L
L
A
A
A
P
V
A
P
S
A
Q
G
L
I
A
L
S
A
V
V
L
V
A
L
L
K
PFADK
M
V
P
R
F
L
L
L
S
A
A
S
M
L
V
M
R
Y
W
F
W
R
L
F
ETLPPPALD
A
S
F
L
F
A
L
L
L
F
A
V
E
T
F
S
I
S
I
F
F
L
N
G
F
L
S
A
D
P
T
D
R
P
FP
R
P
L
Q
PEE
L
P
T
V
D
I
L
V
P
S
Y
N
E
P
A
-
D
M
---
L
S
V
T
L
A
A
A
K
N
M
I
Y
PA
R
--
L
--
R
T
V
V
L
C
D
D
G
G
T
--
D
Q
------
R
-
C
MSPD
P
E
L
A
Q
K
---------
A
--
Q
--
E
----
R
R
R
E
L
--
Q
Q
----------------------
L
--------
C
R
-----
E
L
G
V
V
Y
S
T
R
E
R
NEH
A
K
A
G
N
M
-
S
A
A
L
E
R
L
---
K
---------
G
E
L
V
V
V
F
D
A
D
H
V
P
-
S
R
D
F
L
A
R
----
T
V
G
-
Y
F
V
E
D
P
-
D
L
F
L
V
Q
T
P
H
F
F
I
N
-
P
D
P
I
Q
R
N
----------------------
L
A
--
L
G
----
D
R
---------------------------------------
C
P
P
E
N
E
M
F
Y
G
K
-
I
H
R
G
L
D
R
W
G
G
A
F
-------------------------------
F
C
G
S
A
A
V
-
L
R
R
R
A
L
D
E
A
G
G
F
A
G
E
T
I
T
E
D
A
E
T
A
L
E
I
H
S
R
G
-----
W
K
S
L
Y
I
D
R
A
M
I
A
G
L
Q
P
E
T
F
A
S
F
I
Q
Q
R
G
R
W
A
T
G
M
M
Q
M
L
L
L
KNPLFRRGLG
I
A
Q
R
L
C
Y
L
N
S
M
S
F
W
F
F
P
L
V
R
M
M
F
L
V
A
P
L
I
Y
L
F
FGIEI
F
V
A
T
F
E
E
V
L
A
Y
M
P
G
Y
L
A
V
S
F
L
V
Q
N
A
L
FARQRWPL
V
S
E
V
Y
E
V
A
Q
APYL
A
R
A
I
V
T
T
L
L
RPRSARFAVTAK
D
E
T
L
S
E
NYISPIY
R
P
L
L
F
T
F
L
L
C
L
S
G
V
L
A
T
L
V
R
W
V
A
F
PGD
R
S
V
L
L
V
V
G
G
W
A
V
L
N
V
L
L
V
G
F
A
L
R
AVAEKQQRRA
A
P
R
V
Q
M
E
V
P
A
E
A
Q
I
PAFGNRS
L
T
A
T
V
L
D
ASTS
G
V
R
L
L
V
R
L
PGVGDPHPALEAG
G
L
I
Q
F
Q
P
KFPDAPQLE
R
M
V
R
G
R
I
R
S
A
R
R
E
GG
T
V
M
V
G
V
I
F
EAGQP
I
A
V
R
E
T
V
A
Y
L
I
FGES
A
H
W
R
T
M
R
E
A
T
MRPIG
L
L
H
G
M
A
R
I
L
W
M
A
A
A
S
L
P
K
T
A
R
D
F
M
D
E
P
A
R
R
R
R
R
H
E
EPKEKQAHLLAFGTDF
5
PsiBlast_PDB
62.73
28%
-111
- C2 -
1QGQ
2
SPSA_BACSU
A:
[2-114]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
M
T
S
Y
N
-
K
S
-
D
Y
---
V
A
K
S
I
S
S
I
L
S
Q
T
F
--
S
--
D
--
F
E
L
F
I
M
D
D
N
S
N
--
E
E
------
T
-
L
-----
N
V
I
R
P
FLNDNR
V
R
F
Y
--
Q
--
S
----
D
I
S
G
V
--
K
E
----------------------
R
--------
T
E
-----
K
-------------
T
R
Y
A
A
L
I
N
Q
A
I
E
M
A
---
E
---------
G
E
Y
I
T
Y
A
T
D
D
N
I
Y
-
M
P
D
R
L
L
-----
K
M
V
-
R
E
L
D
T
H
-
P
E
K
A
V
I
Y
S
A
S
K
T
Y
-
H
L
N
D
I
V
K
----------------------
E
T
--
V
R
----
P
A
A
---
Q
V
-------------------
T
W
N
A
P
C
A
-----
I
D
H
C
S
V
M
H
R
Y
S
V
L
E
K
V
K
E
K
F
G
S
Y
W
D
E
S
P
--
A
--
F
Y
R
I
G
D
A
R
F
F
----
W
R
V
-
N
H
F
-
Y
P
F
Y
P
L
D
E
E
-
L
D
L
N
Y
I
T
E
F
V
R
N
L
-
P
P
Q
R
N
C
R
E
L
R
E
S
L
K
K
L
G
M
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.23
28%
-112
- C2 -
1QGS
2
SPSA_BACSU
A:
[2-114]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
M
T
S
Y
N
-
K
S
-
D
Y
---
V
A
K
S
I
S
S
I
L
S
Q
T
F
--
S
--
D
--
F
E
L
F
I
M
D
D
N
S
N
--
E
E
------
T
-
L
-----
N
V
I
R
P
FLNDNR
V
R
F
Y
--
Q
--
S
----
D
I
S
G
V
--
K
E
----------------------
R
--------
T
E
-----
K
-------------
T
R
Y
A
A
L
I
N
Q
A
I
E
M
A
---
E
---------
G
E
Y
I
T
Y
A
T
D
D
N
I
Y
-
M
P
D
R
L
L
-----
K
M
V
-
R
E
L
D
T
H
-
P
E
K
A
V
I
Y
S
A
S
K
T
Y
-
H
L
N
D
I
V
K
----------------------
E
T
--
V
R
----
P
A
A
---
Q
V
-------------------
T
W
N
A
P
C
A
-----
I
D
H
C
S
V
M
H
R
Y
S
V
L
E
K
V
K
E
K
F
G
S
Y
W
D
E
S
P
--
A
--
F
Y
R
I
G
D
A
R
F
F
----
W
R
V
-
N
H
F
-
Y
P
F
Y
P
L
D
E
E
-
L
D
L
N
Y
I
T
E
F
V
R
N
L
-
P
P
Q
R
N
C
R
E
L
R
E
S
L
K
K
L
G
M
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.06
28%
-110
- C2 -
1QG8
-
SPSA_BACSU
A:
[2-114]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
M
T
S
Y
N
-
K
S
-
D
Y
---
V
A
K
S
I
S
S
I
L
S
Q
T
F
--
S
--
D
--
F
E
L
F
I
M
D
D
N
S
N
--
E
E
------
T
-
L
-----
N
V
I
R
P
FLNDNR
V
R
F
Y
--
Q
--
S
----
D
I
S
G
V
--
K
E
----------------------
R
--------
T
E
-----
K
-------------
T
R
Y
A
A
L
I
N
Q
A
I
E
M
A
---
E
---------
G
E
Y
I
T
Y
A
T
D
D
N
I
Y
-
M
P
D
R
L
L
-----
K
M
V
-
R
E
L
D
T
H
-
P
E
K
A
V
I
Y
S
A
S
K
T
Y
-
H
L
N
D
I
V
K
----------------------
E
T
--
V
R
----
P
A
A
---
Q
V
-------------------
T
W
N
A
P
C
A
-----
I
D
H
C
S
V
M
H
R
Y
S
V
L
E
K
V
K
E
K
F
G
S
Y
W
D
E
S
P
--
A
--
F
Y
R
I
G
D
A
R
F
F
----
W
R
V
-
N
H
F
-
Y
P
F
Y
P
L
D
E
E
-
L
D
L
N
Y
I
T
E
F
V
R
N
L
-
P
P
Q
R
N
C
R
E
L
R
E
S
L
K
K
L
G
M
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.93
28%
-111
- C2 -
1H7L
2
SPSA_BACSU
A:
[2-114]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
M
T
S
Y
N
-
K
S
-
D
Y
---
V
A
K
S
I
S
S
I
L
S
Q
T
F
--
S
--
D
--
F
E
L
F
I
M
D
D
N
S
N
--
E
E
------
T
-
L
-----
N
V
I
R
P
FLNDNR
V
R
F
Y
--
Q
--
S
----
D
I
S
G
V
--
K
E
----------------------
R
--------
T
E
-----
K
-------------
T
R
Y
A
A
L
I
N
Q
A
I
E
M
A
---
E
---------
G
E
Y
I
T
Y
A
T
D
D
N
I
Y
-
M
P
D
R
L
L
-----
K
M
V
-
R
E
L
D
T
H
-
P
E
K
A
V
I
Y
S
A
S
K
T
Y
-
H
L
N
D
I
V
K
----------------------
E
T
--
V
R
----
P
A
A
---
Q
V
-------------------
T
W
N
A
P
C
A
-----
I
D
H
C
S
V
M
H
R
Y
S
V
L
E
K
V
K
E
K
F
G
S
Y
W
D
E
S
P
--
A
--
F
Y
R
I
G
D
A
R
F
F
----
W
R
V
-
N
H
F
-
Y
P
F
Y
P
L
D
E
E
-
L
D
L
N
Y
I
T
N
E
F
V
R
N
-
L
P
P
Q
R
N
C
R
E
L
R
E
S
L
K
K
L
G
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
59.84
13%
-62
- C2 -
3CKJ
5
GPGS_MYCPA
A:
[15-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLRDTRPG
D
T
W
L
ADR
S
W
N
R
P
GWT
V
A
E
L
E
A
A
KA
G
R
T
I
S
V
V
L
P
A
L
D
-
E
E
-
D
T
---
I
G
S
V
I
D
S
I
S
P
L
V
D
--
G
L-
V
--
D
E
L
I
V
L
D
S
G
S
T
--
D
D
------
T
-
E
-----
I
R
A
V
A
A
G
A
R
V
----
V
--
S
--
R
----
E
Q
A
L
P
--
E
V
----------------------
P
--------
I
R
-----
P
-------------
G
K
G
E
A
L
-
W
R
S
L
A
A
S
---
R
---------
G
D
I
V
V
F
V
D
S
D
L
I
N
-
P
H
P
M
F
V
P
----
W
L
V
-
G
P
L
L
T
G
-
D
G
V
H
L
V
K
S
F
Y
R
R
P
-
G
R
V
T
E
L
V
----------------------
A
R
--
P
L
----
L
A
A
---
L
R
---------------------
P
E
L
G
C
-----
I
L
Q
P
L
G
G
E
Y
A
A
T
R
E
L
L
T
S
V
P
F
A
P
-------
G
--
Y
G
V
E
I
G
L
L
V
D
----
T
F
D
-
R
L
G
-
L
D
A
I
A
Q
V
N
L
G
V
R
E
H
R
N
R
P
L
A
E
L
G
-
A
M
S
R
Q
V
I
A
T
L
L
S
R
C
G
I
P
D
S
G
V
G
L
T
Q
F
V
A
D
G
P
E
G
Q
S
Y
T
Q
H
T
W
P
V
S
L
A
D
R
P
PMQAIRPR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.81
28%
-110
- C2 -
1H7Q
2
SPSA_BACSU
A:
[2-114]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
S
V
I
M
T
S
Y
N
-
K
S
-
D
Y
---
V
A
K
S
I
S
S
I
L
S
Q
T
F
--
S
--
D
--
F
E
L
F
I
M
D
D
N
S
N
--
E
E
------
T
-
L
-----
N
V
I
R
P
FLNDNR
V
R
F
Y
--
Q
--
S
----
D
I
S
G
V
--
K
E
----------------------
R
--------
T
E
-----
K
-------------
T
R
Y
A
A
L
I
N
Q
A
I
E
M
A
---
E
---------
G
E
Y
I
T
Y
A
T
D
D
N
I
Y
-
M
P
D
R
L
L
-----
K
M
V
-
R
E
L
D
T
H
-
P
E
K
A
V
I
Y
S
A
S
K
T
Y
-
H
L
N
D
I
V
K
----------------------
E
T
--
V
R
----
P
A
A
---
Q
V
-------------------
T
W
N
A
P
C
A
-----
I
D
H
C
S
V
M
H
R
Y
S
V
L
E
K
V
K
E
K
F
G
S
Y
W
D
E
S
P
--
A
--
F
Y
R
I
G
D
A
R
F
F
----
W
R
V
-
N
H
F
-
Y
P
F
Y
P
L
D
E
E
-
L
D
L
N
Y
I
T
D
N
E
F
V
R
-
N
L
P
P
Q
R
N
C
R
E
L
R
E
S
L
K
K
L
G
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
57.01
14%
-103
- C2 -
2ZU9
2
MPGS_PYRHO
A:
[50-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
M
A
V
I
V
P
M
K
N
-
E
K
-
L
------
H
L
V
D
G
V
L
K
A
I
P
--
H
--
K
--
C
P
I
I
I
V
S
N
S
K
R
--
E
G
PN
R
Y
K
L
E
-
V
-----
D
L
I
R
H
---------
F
--
Y
--
N
L
TH
S
K
I
I
M
I
--
H
Q
KD
P
G
L
A
K
A
F
K
E
V
GYTDILDENG
M
--------
I
R
-----
S
-------------
G
K
G
E
G
M
-
L
V
G
L
L
L
A
K
A
I
G
---------
A
E
Y
V
G
F
V
D
A
D
-
N
Y
-
I
P
G
-
A
V
N
E
Y
V
K
D
Y
A
A
G
F
L
M
S
E
S
E
Y
T
M
V
R
L
H
W
R
---------------------------------
V
S
--
E
I
----
T
N
H
Y
L
N
L
L
-------------------
V
S
E
H
-
T
A
FETTI
M
V
T
G
N
A
G
E
H
A
M
T
M
K
L
A
E
I
L
-
P
F
S
T
G
Y
----
S
--
I
E
P
Y
E
I
V
Y
I
L
----
E
-
R
F
G
K
W
-
E
N
V
E
E
F
K
D
V
-
F
D
Q
G
I
E
I
F
Q
I
E
T
L
-
N
P
H
F
H
E
D
K
G
K
E
H
V
K
E
M
L
L
L
S
L
A
T
I
Y
H
S
K
L
A
T
D
N
L
R
K
R
I
L
K
D
L
R
D
H
G
I
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
56.51
11%
-117
- C2 -
1V84
2
B3GA1_HUMAN
A:
[2-129]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
T
I
H
V
V
T
P
T
Y
S
-
R
P
-
V
Q
K
A
E
L
T
R
M
A
N
T
L
-
L
H
V
---
P
--
N
--
L
H
W
L
V
V
E
D
A
P
R
RT
P
L
------
T
-
A
-----
R
L
L
R
D
---------
T
--
G
--
L
----
N
Y
T
H
L
--
H
V
----------------------
E
TP------
R
N
YKLRI
P
-------------
R
G
T
M
Q
R
-
N
L
A
L
R
W
L
---
R
E
T
F
PRNSS
Q
P
G
V
V
Y
F
A
D
D
D
N
T
Y
-
S
L
E
-
L
F
E
----
E
M
R
-
S
T
R
R
V
S
-
V
W
P
V
A
F
V
G
G
L
R
Y
E
-
A
P
R
V
N
G
A
----------------------
G
K
--
V
V
----
R
W
K
---
T
V
-------------------
F
D
P
H
R
P
F
-----
A
I
D
M
A
G
F
A
V
N
L
R
L
I
L
Q
R
S
Q
A
Y
F
K
L
R
G
V
K
--
G
--
G
Y
Q
E
S
S
L
L
R
E
----
L
V
T
-
L
N
D
-
L
E
P
K
A
A
N
C
T
-
K
I
L
V
W
H
T
R
T
E
K
P
V
-
L
V
N
E
G
K
K
G
F
T
D
P
S
V
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------