@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0096: (2015-12-12 )
MKKLILAVFFTLTLSVSAKEVKIVFLETSDIHGRLFSYDYAVGEQKPNNGLTRIATLIKKQRAENKNVVLIDSGDLLQGNSAELFNDEPIHPLVRAENDLKFDIRVLGNHEFNFSKDFLEKNIKGFNGDVVNANIIKIADNKPFVKPYIIKKIDGVRVAVVGFLVPHVPTWEASTPEHFAGLEFLDAEEALKKTLSELKGKYDILIGAFHLGREDEKGGDGIPDLAKKFPQFDIIFAGHEHAVYNTKVGKVHTIEPGAYGAYLAKGVVVFDTKTKKKIITTENLPTKDAPEDEELAKKYEYVDKKSKEYANEVVGEVTKTFIDRPDFITGEEKITTMPTAALQETPVIELINKVQKYYAKADVSAAALFNFGANLKKGPFKRKDVAYIYKFANTLIGVRITGENLLKYMEWSYKFYNQLQPGDLTISFNENVRGYNFDMFSGVKYQVDVTKPAGQRIINPTINGKPINPKAVYKLAINNYRFGTLSTTLKLVTDADRYYDSYDALQDNGQIRDLIIKYITEEKNAKVTPELEHNWEIINYDFKNPLLEKLAEKLKEGSVKIPTSKDGRTLNVKSIKESEVE
Atome Classification :
(21 SA)
------------------------------.........10.......----.20........30....--..---..40-.--.-.......-----50........60...----..----...70........80--......----------.------..90........100.......110-.......120.......130.....----..140-..-...-------...150-----.----..----....160.......170.......180.......190......--.--200.-........210-..-.--....----------220-....--.....--------------------230.........240---------------..--------------...-------------------.--------------.-----.250........260.......270-------..---......280--------.--.--.----------.---...290---------------------------.........300......--.310.......320.......330....------------..---------.340.......350.......---360.--........370---.------.....-.380........390.-......400.......410.......420.....---..430.......440........450........460--------.----..----....470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------MK
K
L
I
L
A
V
F
F
T
L
T
L
S
VSA----
K
E
V
K
I
V
F
L
ETSDIH
G
R
L
--
F
S
---
Y
DY--A--V-GEQKPNN-----
G
L
T
R
I
A
T
L
I
K
K
Q
RAE----NK----
N
V
V
L
IDSGDLLQGN---SAELFN----------D------EPIHP
L
V
RAEND
L
K
F
D
I
R
V
L
GNHEF-NF
S
K
D
F
L
E
K
NIKGFNGDV
V
N
A
N
I
I
K
----IADN--KP-FV
K
-------
P
Y
I
I
KK-----I----D
G
----
V
R
V
A
V
V
G
F
LVPHVPTWEAST
P
E
H
FAGLEFL
D
A
E
E
A
L
K
K
T
L
S
E
L--K--G--K-
Y
D
I
L
I
G
A
F
HLG-RE-D--EKGG----------D---GI
P
D
--
L
A
K
KF--------------------P--Q
F
D
I
I
F
AGHE
H
----------------
A
V
--------------
Y
NT-------------------K--------------V-----
G
K
-
V
H
T
IEPGA
Y
G
A
Y
LAK
G
V
V
V
F
-D-------TK---TK
K
K
I
I
TTE--------N--L--P----------T---KDAP-----------------------------
E
D
E
E
L
A
K
K
Y
E
Y
V
D
K
K
S
K
E
--
Y
A
N
E
V
V
G
E
V
T
K
T
FIDRPDFITGEE
K
I
TT------------MP---------
T
A
ALQET
P
V
I
E
L
I
N
K
V
Q
K
Y
Y
A
---K--A--D
V
S
A
A
A
L
F
NFG---A------NLKKG-PF-KR
K
D
V
A
Y
I
Y
K
F
A
N
-
T
L
I
G
V
R
IT
G
E
N
L
L
K
Y
M
E
W
S
Y
K
F
Y
NQLQPG
D
L
T
I
S
---FNENVRGYNFDMFS-G
V
K
Y
Q
V
D
VTK-PAG
Q
R
I
INPTI--------N----GK----PI
N
P
K
A
V
Y
K
L
A
INN
Y
R
FG
T
L
S
T
T
L
K
L
V
T
D
A
D
R
YY
D
S
Y
D
A
LQDNG
Q
I
R
D
L
I
I
K
Y
I
TEEKNAKVTPELEHN
W
E
I
I
N
YDFK
N
P
L
L
E
K
L
A
E
K
L
KEG
S
V
KIPTSKDG
R
T
L
N
V
K
SIKESEVE
2
PsiBlast_PDB
90.68
27%
-70
- C1 -
4Q7F
3
?
A:
[20-478]
--------------------------------------------------------
I
A
F
Y
V
V
S
D
V
H
G
Y
I
--
F
P
---
T
D
F
--
T
--
S
-
R
N
Q
Y
Q
P
M
-----
G
L
L
L
A
N
H
V
I
E
Q
D
R
R
Q
----
Y
D
----
Q
S
F
K
I
D
N
G
D
F
L
Q
G
S
P
F
C
N
Y
L
I
A
H
----------
S
------
G
S
S
Q
P
L
V
D
F
Y
N
R
M
A
F
D
F
G
T
L
G
N
H
E
F
-
N
Y
G
L
P
Y
L
K
D
T
L
R
R
L
N
Y
P
V
L
C
A
N
I
Y
E
NDST
L
T
D
N
--
G
---
V
K
-------
Y
F
---
Q
-----
V
----
G
D
----
Q
T
V
G
V
I
G
L
T
T
Q
F
I
P
H
W
E
Q
--
P
E
H
I
Q
S
L
T
F
H
S
A
F
E
I
L
Q
Q
Y
L
P
E
M
--
K
--
R
--
H
-
A
D
I
I
V
V
C
Y
H
G
G
-
F
E
K
D
--
L
E
S
G
TPTEVLTGEN
E
---
G
Y
A
M
--
L
E
A
F
S
--------------------
K
--
D
I
D
I
F
I
T
G
H
Q
H
----------------
R
Q
--------------
I
A
E
-------------------
R
--------------
F
-----
K
Q
-
T
A
V
I
Q
P
G
T
R
G
T
T
V
G
R
V
V
L
S
T
-
D
-------
E
Y
---
E
N
L
S
V
E
S
C
E
--------
L
--
L
--
P
----------
V
---
I
D
D
S
T
F
T
I
D
E
-----------------------
D
D
Q
H
L
R
K
Q
L
E
------------------------
D
W
L
D
Y
-----
E
I
T
T
------------
L
P
YDMTINH
A
F
E
A
R
V
A
P
H
P
F
T
N
F
M
N
Y
A
L
L
E
K
S
---
D
--
A
--
D
V
A
C
T
A
L
F
D
S
A
---
S
------
G
F
K
Q
--
V
V
-
T
M
R
D
V
I
N
N
Y
P
F
P
N
-
T
F
K
V
L
A
V
S
G
A
K
L
K
E
A
I
E
R
S
A
E
Y
F
D
-
V
K
N
D
E
V
S
V
S
ADF
L
E
P
K
P
Q
H
F
N
Y
D
I
Y
G
-
G
V
S
Y
T
I
H
V
G
R
-
P
K
G
Q
R
V
S
N
M
M
I
--------
Q
----
G
H
----
A
V
D
L
K
Q
T
Y
T
I
C
V
N
N
Y
R
A
V
G
G
G
Q
Y
D
M
Y
I
D
A
P
V
V
K
D
I
Q
V
E
G
A
Q
L
L
I
D
F
L
S
N
N
N
L
M
R
I
P
Q
V
V
D
F
K
V
E
K
---------------------------------------------------
1
PsiBlast_PDB
89.40
27%
-70
- C1 -
3QFK
4
?
A:
[20-478]
--------------------------------------------------------
I
A
F
Y
V
V
S
D
V
H
G
Y
I
--
F
P
---
T
D
F
--
T
--
S
-
R
N
Q
Y
Q
P
M
-----
G
L
L
L
A
N
H
V
I
E
Q
D
R
R
Q
----
Y
D
----
Q
S
F
K
I
D
N
G
D
F
L
Q
G
S
P
F
C
N
Y
L
I
A
H
----------
S
------
G
S
S
Q
P
L
V
D
F
Y
N
R
M
A
F
D
F
G
T
L
G
N
H
E
F
-
N
Y
G
L
P
Y
L
K
D
T
L
R
R
L
N
Y
P
V
L
C
A
N
I
Y
E
NDST
L
T
D
N
--
G
---
V
K
-------
Y
F
---
Q
-----
V
----
G
D
----
Q
T
V
G
V
I
G
L
T
T
Q
F
I
P
H
W
E
Q
--
P
E
H
I
Q
S
L
T
F
H
S
A
F
E
I
L
Q
Q
Y
L
P
E
M
--
K
--
R
--
H
-
A
D
I
I
V
V
C
Y
H
G
G
-
F
E
K
D
--
L
E
S
G
TPTEVLTGEN
E
---
G
Y
A
M
--
L
E
A
F
S
--------------------
K
--
D
I
D
I
F
I
T
G
H
Q
H
----------------
R
Q
--------------
I
A
E
-------------------
R
--------------
F
-----
K
Q
-
T
A
V
I
Q
P
G
T
R
G
T
T
V
G
R
V
V
L
S
T
-
D
-------
E
Y
---
E
N
L
S
V
E
S
C
E
--------
L
--
L
--
P
----------
V
---
I
D
D
S
T
F
T
I
D
E
-----------------------
D
D
Q
H
L
R
K
Q
L
E
------------------------
D
W
L
D
Y
-----
E
I
T
T
------------
L
P
YDMTINH
A
F
E
A
R
V
A
P
H
P
F
T
N
F
M
N
Y
A
L
L
E
K
S
---
D
--
A
--
D
V
A
C
T
A
L
F
D
S
A
---
S
------
G
F
K
Q
--
V
V
-
T
M
R
D
V
I
N
N
Y
P
F
P
N
-
T
F
K
V
L
A
V
S
G
A
K
L
K
E
A
I
E
R
S
A
E
Y
F
D
-
V
K
N
D
E
V
S
V
S
ADF
L
E
P
K
P
Q
H
F
N
Y
D
I
Y
G
-
G
V
S
Y
T
I
H
V
G
R
-
P
K
G
Q
R
V
S
N
M
M
I
--------
Q
----
G
H
----
A
V
D
L
K
Q
T
Y
T
I
C
V
N
N
Y
R
A
V
G
G
G
Q
Y
D
M
Y
I
D
A
P
V
V
K
D
I
Q
V
E
G
A
Q
L
L
I
D
F
L
S
N
N
N
L
M
R
I
P
Q
V
V
D
F
K
V
E
K
---------------------------------------------------
21
HHSearch
88.63
23%
-65
- C1 -
2Z1A
4
?
A:
[28-534]
------------------------------------------------------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
L
--
E
P
---
V
E
L
--
T
--
L
S
G
E
K
T
P
V
G
-----
G
V
A
R
R
V
A
L
F
D
R
V
W
A
R
----
A
K
----
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
---
L
Y
F
N
Q
------------------
Y
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
-
D
L
G
P
G
P
L
A
D
F
L
K
G
A
R
F
K
V
V
S
A
N
V
D
A
----
S
R
E
P
RL
K
G
-
L
F
A
-------
P
Y
A
V
V
V
-----
V
----
G
G
----
E
R
V
G
I
I
G
L
T
T
P
D
T
R
E
I
S
--
N
P
--
G
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
--
L
A
-
K
--
G
-
V
N
K
I
V
V
L
S
H
L
G
-
Y
G
-
E
--
D
-------------------
L
K
--
L
A
R
R
L
--------------------
V
--
G
V
Q
V
I
V
G
G
H
S
H
----------------
T
L
--------------
L
G
S
F
PHKELSPAGPY
P
T
V
V
K
N
P
E
--------------
G
-----
K
D
-
V
L
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
-
D
-------
A
K
---
G
E
L
L
A
Y
K
G
E
--------
A
L
L
M
--
T
----------
P
---
E
A
A
P
-----------------------------
E
D
F
F
A
K
E
A
L
L
A
Y
A
Q
P
V
M
A
--
L
M
Q
Q
V
I
A
E
A
K
V
D
L
V
G
E
------------------------
R
A
---------
V
V
R
R
R
E
S
N
L
G
N
L
I
T
D
G
M
L
W
K
T
R
NA
G
--
T
--
Q
I
A
L
Q
N
G
G
G
I
R
---
A
------
S
I
P
K
G
-
P
I
-
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
E
N
-----------------
T
A
G
R
F
L
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
-
P
A
G
S
R
V
V
R
V
E
V
--------
K
T
EKG
Y
V
----
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
-
T
V
L
K
E
A
Q
G
Y
R
-----
V
D
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
K
--
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
----------------------------------------
24
HHSearch
83.65
21%
-63
- C1 -
1HP1
7
USHA_ECOLI
A:
[3-500]
----------------------------------------------
Q
D
----
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
-----------
Y
G
E
Y
-----
G
L
A
A
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
P
E
S
D
L
------------------
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
T
A
K
I
G
--
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
Q
T
E
--
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
--
N
G
E
H
GSNA------
P
---
G
D
V
E
--
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
----------------
D
P
--------------
V
C
M
AAENKKQVDYVPG
T
P
C
K
P
D
Q
--------------
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
-------
N
G
E
--
M
K
M
V
N
Y
Q
L
I
P
VNLKKKR
V
--
L
--
Y
----------
T
---
P
E
I
A
-----------------------------
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
--
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
------------
D
------------
R
D
---------
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
------------------
D
S
G
A
Y
P
Q
F
A
-
N
V
S
F
V
A
K
------
D
G
K
L
N
D
L
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
-
P
R
L
D
N
K
P
G
Y
------
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
------------------------------------------
6
PsiBlast_PDB
82.60
26%
-58
- C1 -
2Z1A
4
?
A:
[28-481]
---------------------------------------
F
T
L
T
L
---------------
V
H
T
N
D
T
H
A
H
L
--
E
P
---
V
E
L
--
T
--
L
S
G
E
K
T
P
V
G
-----
G
V
A
R
R
V
A
L
F
D
R
V
W
A
R
----
A
K
----
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
---
L
--
Y
F
N
----------
Q
------
Y
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
-
D
L
G
P
G
P
L
A
D
F
L
K
G
A
R
F
K
V
V
S
A
N
V
------
D
A
S
R
--
E
P
-
R
L
K
GLFA---
P
Y
A
V
V
V
-----
V
----
G
G
----
E
R
V
G
I
I
G
L
T
T
P
D
--
T
R
E
I
S
N
P
G
--
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
K
--
G
--
V
-
N
K
I
V
V
L
S
-
H
L
G
Y
G
E
-
D
--
L
K
----------------------
L
A
R
R
L
--------------------
V
--
G
V
Q
V
I
V
G
G
H
S
H
----------------
T
L
L
G
S
F
PHKELSPAGP
Y
P
T
-------------------
V
--------------
V
K
N
PE-
G
K
D
V
L
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
-
D
-------
A
K
---
G
E
L
L
A
Y
K
G
E
--------
A
--
L
L
M
T
----------
P
---
E
A
A
P
-----------------------------
E
D
-------
F
F
A
K
E
A
L
L
A
--
Y
A
Q
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
D
L
V
G
E
R
A
V
V
R
------------
R
--------------
R
E
S
N
L
G
N
L
I
T
D
G
M
L
W
K
T
---
R
--
N
--
A
G
T
Q
I
A
L
Q
N
G
G
GIR
A
------
S
I
P
K
G
-
P
I
-
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
-------------
V
S
---
Q
W
E
N
T
A
G
-
R
F
L
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
-
P
A
G
S
R
V
V
R
V
E
V
--------
K
----
T
E
KGYV
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
A
Q
G
Y
R
V
D
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
L
K
V
V
E
A
G
L
E
G
R
I
E
V
L
N
E
P
------------------------------------------------
7
PsiBlast_PDB
82.24
22%
-60
- C1 -
2USH
7
USHA_ECOLI
A:
[26-498]
------------------------------------------------YEQD
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
Y
-------
G
E
Y
G
L
A
A
-----
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
----
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
P
E
S
D
L
Q
----------
D
--------
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
A
K
-----
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
--
Q
T
E
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
NG
E
H
G
S
----------
N
AP-
G
D
V
E
--
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
DPVCM-----------
A
A
--------------
E
N
K
-------------------
K
QV
D
Y
V
P
G
T
P
C
K
P
D
Q
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
---------
R
N
---
G
E
M
K
M
V
N
Y
Q
--------
L
--
I
--
P
----------
V
---
N
------------------------------------
L
K
K
K
V
------
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
KI
G
E
T
NGRLEGD
R
D
---------
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
----
T
A
V
A
Q
M
K
P
D
S
G
A
--------------
Y
P
Q
F
A
-
N
V
S
F
---
V
A
K
----------
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
--------------------------------------------------
42
Fugue
81.33
20%
-52
- C1 -
3ZTV
4
5NTD_HAEIN
A:
[8-573]
-----------------------------------------------
H
----
K
A
V
E
L
S
I
L
H
I
N
D
H
H
S
Y
L
--
E
P
---
H
E
T
--
R
--
I
-
N
L
N
G
Q
Q
T
K
V
D
I
G
G
F
S
A
V
N
A
K
L
N
K
L
R
K
K
----
Y
K
----
N
P
L
V
L
H
A
G
D
A
I
T
G
T
-----
L
Y
F
T
----------
L
------
F
G
G
S
A
D
A
A
V
M
N
A
G
N
F
H
Y
F
T
L
G
N
H
E
F
-
D
A
G
N
E
G
L
L
K
L
L
E
P
L
K
I
P
V
L
S
A
N
V
I
P
----
D
K
S
S
IL
Y
N
-
K
W
K
-------
P
Y
D
I
F
T
-----
V
----
D
G
----
E
K
I
A
I
I
G
L
D
T
V
-
N
K
T
V
N
S
S
S
P
G
--
K
D
V
K
F
Y
D
E
I
A
T
A
Q
I
M
A
N
A
L
--
K
--
Q
--
Q
G
I
N
K
I
I
L
L
S
H
A
G
----------
S
----------
E
---
K
N
I
E
--
I
A
Q
K
V
--------------------
N
--
D
I
D
V
I
V
T
G
D
S
H
YLYGN
D
E
L
R
S
L
KLPVI
Y
E
--------------
Y
P
L
-------------------
E
--------------
F
K
N
PNG
E
P
-
V
F
V
M
E
G
W
A
Y
S
A
V
V
G
D
L
G
V
K
F
-
S
PEG
I
A
S
I
T
R
---
K
I
P
H
V
L
M
S
S
--------
H
--
K
--
L
----------
Q
---
V
K
N
S
EG
K
W
A
E
L
T
G
D
E
R
K
K
A
L
D
T
L
K
S
MKSISLD
D
H
D
A
K
T
D
K
L
I
A
K
Y
K
S
E
K
D
R
--
L
A
Q
E
I
V
G
V
I
T
G
S
A
M
P
G
G
S
A
N
R
I
P
N
K
A
G
S
------------
N
P
---------
E
G
S
I
A
T
R
F
I
A
E
T
M
Y
N
E
---
L
K
---
T
--
V
--
D
L
T
I
Q
N
A
G
G
V
R
---
A
------
D
I
L
P
G
-
N
V
-
T
F
N
D
A
Y
T
F
L
P
F
G
N
-
T
L
Y
T
Y
K
M
E
G
S
L
V
K
Q
V
L
E
D
A
M
Q
F
A
L
V
---------------
D
G
S
T
G
A
F
P
Y
G
A
-
G
I
R
Y
E
A
N
E
T
P
N
A
E
G
K
R
L
V
S
V
E
V
L
NKTQ---
Q
----
W
E
----
P
I
D
D
N
K
R
Y
L
V
G
T
N
A
Y
V
A
G
G
K
--------------
D
G
Y
K
T
F
G
K
L
F
N
D
P
K
Y
E
-----------------------
G
V
D
T
Y
L
P
D
A
E
S
F
I
K
F
M
K
K
H
P
H
F
E
A
Y
T
S
S
N
V
K
F
N
A
S
T
-------
22
HHSearch
80.29
22%
-59
- C1 -
3IVE
5
?
A:
[4-501]
-----------------------------------------------------
A
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
--
E
P
---
Y
K
V
--
P
WI
A
-
D
G
K
R
D
I
G
-----
G
W
A
N
I
T
T
L
V
K
Q
E
K
A
K
----
N
K
----
A
T
W
F
F
D
A
G
D
Y
F
T
G
P
---
Y
I
S
S
L
------------------
T
K
G
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
-
D
H
G
W
D
N
T
L
L
Q
L
S
Q
A
K
F
P
I
V
Q
G
N
I
F
Y
----
Q
N
S
S
--
K
S
F
W
D
K
-------
P
Y
T
I
I
E
-----
K
----
D
G
----
V
K
I
G
V
I
G
L
H
G
V
F
A
F
N
D
T
V
-
S
A
A
T
R
V
G
I
E
A
R
D
E
I
K
W
L
Q
R
Y
I
D
E
L
--
K
--
G
--
K
-
V
D
L
T
V
A
L
I
H
E
G
-
V
P
-
A
--
R
Q
S
S
MD
V
R
R
A
L---
D
---
K
D
I
Q
--
T
A
S
Q
V
--------------------
K
--
G
L
D
I
L
I
T
G
H
A
H
----------------
V
G
--------------
T
P
E
-------------------
P
I
K
------------
V
-----
G
N
-
T
L
I
L
S
T
D
S
G
G
I
D
V
G
K
L
V
L
D
Y
-
K
-------
E
K
PH
N
F
T
V
K
N
F
E
L
K
--------
T
--
I
--
Y
----------
A
---
D
E
W
K
-----------------------------
P
D
Q
Q
T
K
Q
V
I
D
G
W
N
K
K
L
D
E
--
V
V
Q
Q
T
V
A
Q
S
P
V
E
L
K
-------------------------------------
R
A
Y
G
E
S
A
S
L
G
N
L
A
A
D
A
L
L
A
A
A
---
G
KN
T
--
Q
L
A
L
T
N
S
G
G
I
R
---
N
------
E
I
P
A
G
-
A
I
-
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
G
A
S
L
S
---------------------
N
G
V
L
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
-
P
V
G
Q
R
V
I
T
L
T
L
--------
N
----
G
K
----
P
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
-
T
A
F
T
E
G
K
A
R
N
-----
I
T
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
A
G
N
--
T
I
T
D
E
Q
L
N
G
M
R
V
K
D
I
K
----------------------------------------
20
PsiBlast_PDB
79.29
21%
-55
- C1 -
4H1Y
6
5NTD_HUMAN
P:
[25-519]
-------------------------------------------------------
E
L
T
I
L
H
T
N
D
V
H
S
R
L
EQ
T
S
---
E
D
S
SK
C
--
V
-
D
A
S
R
C
M
G
-----
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
A
----
E
P
----
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
---
I
--
W
F
T
----------
V
------
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
-------
I
S
A
S
--
G
P
-
L
A
S
QISGLYL
P
Y
K
V
L
P
-----
V
----
G
D
----
E
V
V
G
I
V
G
Y
T
S
K
E
T
P
F
--
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
--
K
--
T
L-
N
-
V
N
K
I
I
A
L
G
H
S
G
-
F
E
-
M
--
D
K
-------------------
L
--
I
A
Q
K
V
RGVDVVVGGHSNTFLYTGNP
P
--
S
K
E
V
P
A
G
K
Y
P
F
----------------
I
V
--------------
T
S
D
-------------------
D
--------------
G
-----
R
K
-
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
------------
E
R
G
N
V
I
S
S
H
--------
G
--
N
--
P
----------
I
LLD
S
S
I
P
-----------------------------
E
D
P
S
I
K
A
D
I
N
K
W
R
I
K
L
D
D
--
Y
S
T
Q
---
E
L
G
K
T
I
V
----
Y
L
D
G
S
S
Q
S
C
R
------------
F
R
---------
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
A
D
---
E
--
M
FW
N
H
V
S
M
C
I
L
N
G
G
---
G
IRSPID
E
R
N
D
G
-
T
I
-
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
Q
--------
S
---
T
G
E
------
F
L
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
-
K
P
G
D
R
V
V
K
L
D
V
LCTSCRVP
S
----
Y
D
----
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
-
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
L
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
M
K
V
I
Y
P
A
V
E
G
R
I
K
F
S
---------------------------------------------------
8
PsiBlast_PDB
79.19
22%
-60
- C1 -
1USH
7
USHA_ECOLI
A:
[26-498]
------------------------------------------------YEQD
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
Y
-------
G
E
Y
G
L
A
A
-----
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
----
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
P
E
S
D
L
Q
----------
D
--------
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
--
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
NG
E
H
G
S
----------
N
AP-
G
D
V
E
--
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
DPVCM-----------
A
A
--------------
E
N
K
-------------------
K
QVDYVPG
T
P
C
K
P
D
Q
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
---------
R
N
---
G
E
M
K
M
V
N
Y
Q
--------
L
--
I
--
P
----------
V
---
N
------------------------------------
L
K
K
----------
R
VL
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
KI
G
E
T
N
G
R
L
E
GD
R
D
---------
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
----
T
A
V
A
Q
M
K
P
D
S
G
A
--------------
Y
P
Q
F
A
-
N
V
S
F
---
V
A
K
-
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------
11
PsiBlast_PDB
79.15
22%
-61
- C1 -
1HO5
4
USHA_ECOLI
A:
[5-473]
----------------------------------------------------
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
Y
-------
G
E
Y
G
L
A
A
-----
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
----
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
P
E
S
D
L
Q
----------
D
--------
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
--
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
NG
E
H
G
S
----------
N
AP-
G
D
V
E
--
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
DPVCM-----------
A
A
--------------
E
N
K
-------------------
K
QVDYVPG
T
P
C
K
P
D
Q
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
---------
R
N
---
G
E
M
K
M
V
N
Y
Q
--------
L
--
I
--
P
----------
V
---
N
------------------------------------
L
K
K
K
V
T
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
KIGETNGRLEGD
R
D
---------
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
----
T
A
V
A
Q
M
K
P
D
S
G
A
--------------
Y
P
Q
F
A
-
N
V
S
F
---
V
A
K
-
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------
9
PsiBlast_PDB
79.11
22%
-57
- C1 -
1OI8
4
USHA_ECOLI
A:
[5-473]
----------------------------------------------------
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
Y
-------
G
E
Y
G
L
A
A
-----
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
----
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
C
E
S
D
L
Q
----------
D
--------
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
--
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
NG
E
H
G
S
----------
N
AP-
G
D
V
E
--
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
DPVCM-----------
A
A
--------------
E
N
K
-------------------
K
QVDYVPG
T
P
C
K
P
D
Q
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
---------
R
N
---
G
E
M
K
M
V
N
Y
Q
--------
L
--
I
--
P
----------
V
---
N
------------------------------------
L
K
K
K
V
T
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
KI
G
E
T
NGRLEGD
R
D
---------
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
C
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
----
T
A
V
A
Q
M
K
P
D
S
G
A
--------------
Y
P
Q
F
A
-
N
V
S
F
---
V
A
K
-
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
E
------------------------------------------------
12
PsiBlast_PDB
78.93
22%
-60
- C1 -
1HPU
3
USHA_ECOLI
A:
[5-473]
----------------------------------------------------
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
Y
-------
G
E
Y
G
L
A
A
-----
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
----
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
P
E
S
D
L
Q
----------
D
--------
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
--
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
NG
E
H
G
S
----------
N
AP-
G
D
V
E
--
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
DPVCM-----------
A
A
--------------
E
N
K
-------------------
K
QVDYVPG
T
P
C
K
P
D
Q
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
---------
R
N
---
G
E
M
K
M
V
N
Y
Q
--------
L
--
I
--
P
----------
V
---
N
------------------------------------
L
K
K
K
V
T
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
KIGETN
G
R
L
E
GD
R
D
---------
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
----
T
A
V
A
Q
M
K
P
D
S
G
A
--------------
Y
P
Q
F
A
-
N
V
S
F
---
V
A
K
-
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------
10
PsiBlast_PDB
78.81
21%
-66
- C1 -
1HP1
7
USHA_ECOLI
A:
[5-464]
----------------------------------------------------
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
Y
-------
G
E
Y
G
L
A
A
-----
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
----
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
P
E
S
D
L
Q
----------
D
--------
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
--
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
NG
E
H
G
S
----------
N
---
A
P
G
D
V
E
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
DPVCM-----------
A
A
--------------
E
N
K
-------------------
K
QVDYVPG
T
P
C
K
P
D
Q
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
---------
R
N
---
G
E
M
K
M
V
N
Y
Q
--------
L
--
I
--
P
VNLKKKRVLY
T
---
P
E
I
A
-----------------------------
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
--
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
V
R
---------------------------------
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
----
T
A
V
A
Q
M
K
P
D
S
G
A
--------------
Y
P
Q
F
A
-
N
V
S
F
---
V
A
K
-
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------
44
Fugue
78.76
17%
-47
- C1 -
2WDC
18
?
A:
[21-562]
YDLPPYGDATLLYFSDLHGQA
F
P
H
Y
F
M
E
P
P
N
L
I
A
P
K
P
L
M
G
R
P
G
Y
L
T
G
E
----
A
I
L
R
Y
Y
G
V
E
R
G
T
P
L
A
Y
L
--
L
S
YVD
F
V
E
--
L
--
A
-
R
T
F
G
P
I
G
-----
G
M
G
A
L
T
A
L
I
R
D
Q
K
A
R
----
V
E
A
E
G
G
K
A
L
V
L
D
G
G
D
T
W
T
N
S
---
G
L
S
L
L
T
----------
R
------
G
--
E
A
V
V
R
W
Q
N
L
V
G
V
D
H
M
V
-
S
H
W
E
W
-
T
L
G
R
E
R
V
E
E
L
L
G
L
F
R
G
E
F
L
S
Y
N
I
V
D
----
D
L
F
G
--
D
P
-
L
F
P
-------
A
Y
R
I
H
R
-----
V
----
G
P
----
Y
A
L
A
V
V
G
A
S
Y
P
Y
V
K
V
S
H
--
P
E
S
F
T
E
G
L
S
F
A
L
D
E
R
R
L
Q
E
A
V
D
K
A
--
R
--
A
--
E
G
A
N
A
V
V
L
L
S
H
----------
N
G
M
----------
Q
---
L
D
A
A
--
L
A
E
R
I
--------------------
R
--
G
I
D
L
I
L
S
G
H
T
H
----------------
D
L
TP------------
R
P
W
-------------------
R
--------------
V
-----
G
K
-
T
W
I
V
A
G
S
A
A
G
K
A
L
M
R
V
D
L
K
L
W
K
-------
G
G
---
I
A
N
L
R
V
R
V
L
--------
P
--
V
--
L
----------
A
---
E
H
L
P
-----------------------------
K
A
E
D
V
E
A
F
L
K
A
Q
L
A
P
H
Q
D
--
H
L
F
T
P
L
A
V
S
E
T
L
L
Y
K
R
D
T
L
Y
S
---
T
W
D
Q
------------
L
V
---------
G
E
A
V
K
A
I
------------
Y
P
---
E
--
V
--
E
V
V
F
S
P
A
V
R
W
G
---
T
------
T
I
L
P
G
-
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
D
I
A
S
N
V
F
T
S
D
P
F
Y
Q
-----------
Q
G
G
D
V
S
R
V
F
-
G
L
R
Y
V
L
D
P
D
A
-
P
T
G
E
R
V
R
E
V
E
V
--------
G
----
G
R
----
P
L
D
P
N
R
R
Y
L
A
A
A
Y
G
--------------
G
R
L
Q
R
V
G
E
A
K
P
G
Y
E
P
R
P
I
Y
E
V
L
A
E
Y
L
R
S
V
G
--
R
V
R
V
R
P
E
P
N
V
K
V
I
G
R
N
Y
R
L
P
E
V
T
G
--------------------------------
13
PsiBlast_PDB
78.71
22%
-58
- C1 -
4WWL
15
USHA_ECOLI
A:
[5-473]
----------------------------------------------------
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
Y
-------
G
E
Y
G
L
A
A
-----
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
----
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
P
E
S
D
L
Q
----------
D
--------
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
--
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
NG
E
H
G
S
----------
N
AP-
G
D
V
E
--
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
DPVCM-----------
A
A
--------------
E
N
K
-------------------
K
QVDYVPG
T
P
C
K
P
D
Q
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
---------
R
N
---
G
E
M
K
M
V
N
Y
Q
--------
L
--
I
--
P
----------
V
---
N
------------------------------------
L
K
K
K
V
T
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
KI
G
E
T
N
G
R
L
E
GD
R
D
---------
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
----
T
A
V
A
Q
M
K
P
D
S
G
A
--------------
Y
P
Q
F
A
-
N
V
S
F
---
V
A
K
-
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
Y
V
N
T
G
F
C
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------
14
PsiBlast_PDB
78.59
22%
-63
- C1 -
1OID
1
USHA_ECOLI
A:
[5-473]
----------------------------------------------------
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
Y
-------
G
E
Y
G
L
A
A
-----
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
----
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
P
E
S
D
L
Q
----------
D
--------
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
--
Q
TE
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
NG
E
H
G
C
----------
N
AP-
G
D
V
E
--
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
DPVCM-----------
A
A
--------------
E
N
K
-------------------
K
QVDYVPG
T
P
C
K
P
D
Q
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
---------
R
N
---
G
E
M
K
M
V
N
Y
Q
--------
L
--
I
--
P
----------
V
---
N
------------------------------------
L
K
K
K
V
T
W
E
D
G
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
KIGETNGRLEGD
R
D
---------
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
----
T
A
V
A
Q
M
K
P
D
S
G
A
--------------
Y
P
Q
F
A
-
N
V
S
F
---
V
A
K
-
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
C
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
-------------------------------------------------
15
PsiBlast_PDB
78.06
22%
-62
- C1 -
1OIE
1
USHA_ECOLI
A:
[5-473]
----------------------------------------------------
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--
W
R
---
N
E
Y
-------
G
E
Y
G
L
A
A
-----
Q
K
T
L
V
D
G
I
R
K
E
V
A
A
E
----
G
G
----
S
V
L
L
L
S
G
G
D
I
N
T
G
V
---
P
E
S
D
L
Q
----------
D
--------
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
-
D
N
P
L
T
V
L
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
----
K
S
T
G
--
E
R
-
L
F
K
-------
P
W
A
L
F
K
-----
R
----
Q
D
----
L
K
I
A
V
I
G
L
T
T
D
D
--
T
A
K
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
--
Q
--
Q
T
E
K
-
P
D
I
I
I
A
A
T
H
M
G
-
H
Y
-
D
NG
E
H
G
C
----------
N
AP-
G
D
V
E
--
M
A
R
A
L
--------------------
P
AG
S
L
A
M
I
V
G
G
H
S
Q
DPVCM-----------
A
A
--------------
E
N
K
-------------------
K
QVDYVPG
T
P
C
K
P
D
Q
Q
-----
N
G
-
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
---------
R
N
---
G
E
M
K
M
V
N
Y
Q
--------
L
--
I
--
P
----------
V
---
N
------------------------------------
L
K
K
K
V
------
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
KIGETN
G
R
L
E
GD
R
D
---------
K
V
R
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
---
G
--
A
--
D
F
A
V
M
S
G
G
G
I
R
---
D
------
S
I
E
A
G
-
D
I
-
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
----
T
A
V
A
Q
M
K
P
D
S
G
A
--------------
Y
P
Q
F
A
-
N
V
S
F
---
V
A
K
-
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
----
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
C
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
S
S
P
L
D
V
S
V
Y
E
P
K
G
E
V
S
W
Q
E
------------------------------------------------
26
HHSearch
77.77
31%
-59
- C1 -
3JYF
12
?
A:
[4-338]
-----------------------------------------------
A
----
A
T
V
D
L
R
I
M
E
T
T
D
L
H
S
N
M
--
M
D
---
F
D
Y
--
Y
--
K
-
D
A
A
T
E
K
F
-----
G
L
V
R
T
A
S
L
I
E
Q
A
R
A
E
----
V
K
----
N
S
V
L
V
D
N
G
D
V
I
Q
G
S
---
P
L
G
D
Y
M
----------
A
A
K
GLKE
G
D
V
H
P
V
Y
K
A
M
N
T
L
N
Y
A
V
G
N
L
G
N
H
E
F
-
N
Y
G
L
D
F
L
H
K
A
L
A
G
A
K
F
P
Y
V
N
A
N
I
I
D
----
A
K
T
G
--
K
P
-
M
F
T
-------
P
Y
L
I
Q
D
T
R
V
V
D
S
----
D
G
Q
I
H
T
L
R
I
G
Y
I
G
F
V
P
P
Q
I
M
T
W
D
K
--
A
N
L
N
G
K
V
T
V
N
D
I
T
E
T
A
R
K
Y
I
P
E
M
--
R
A
-
K
--
G
-
A
D
V
V
V
V
V
A
H
S
G
-
L
S
-
A
--
D
P
Y
Q
----------
A
MAE
N
S
V
Y
--
Y
L
S
Q
V
--------------------
P
--
G
V
D
A
I
M
F
G
H
A
H
----------------
A
V
--------------
F
P
G
-------------------
K
DFANIKGADIAKGT
L
-----
N
G
-
V
P
A
V
M
P
G
M
W
G
D
H
L
G
V
V
D
L
V
L
-
N
-------
N
D
SG
K
W
Q
V
T
Q
S
K
A
E
--------
A
--
R
--
P
IYDAVAK---
K
---
S
L
A
A
-----------------------------
E
D
G
K
L
V
S
V
L
K
A
D
H
D
A
T
R
E
--
F
V
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
77.51
19%
-61
- C1 -
2WDC
17
?
A:
[99-559]
-----------------------------------------------------------------------------------------
G
P
I
G
-----
G
M
G
A
L
T
A
L
I
R
D
Q
K
A
R
V
E
A
E
G
G
----
K
A
L
V
L
D
G
G
D
T
W
T
N
S
---
G
L
S
L
L
------------------
T
R
G
E
A
V
V
R
W
Q
N
L
V
G
V
D
H
M
V
-
S
H
W
E
W
-
T
L
G
R
E
R
V
E
E
L
L
G
L
F
R
G
E
F
L
S
Y
N
I
V
D
----
D
L
F
G
--
D
P
-
L
F
P
-------
A
Y
R
I
H
R
-----
V
----
G
P
----
Y
A
L
A
V
V
G
A
S
Y
P
Y
V
K
V
S
H
--
P
E
S
F
T
E
G
L
S
F
A
L
D
E
R
R
L
Q
E
A
V
D
K
A
--
R
A
-
E
--
G
-
A
N
A
V
V
L
L
S
H
N
G
-
M
Q
-
L
--
D
-------------------
A
A
--
L
A
E
R
I
--------------------
R
--
G
I
D
L
I
L
S
G
H
T
H
----------------
D
L
--------------
T
P
R
-------------------
P
W
R
------------
V
-----
G
K
-
T
W
I
V
A
G
S
A
A
G
K
A
L
M
R
V
D
L
K
L
-
W
-------
K
G
---
G
-
I
A
N
L
R
V
R
--------
V
--
L
--
P
VL--------
A
---
E
H
L
P
-----------------------------
K
A
E
D
V
E
A
F
L
K
A
Q
L
A
P
H
Q
D
--
H
L
F
T
P
L
A
V
S
E
T
L
L
Y
-------------------------------------
K
R
D
T
L
Y
S
T
W
D
Q
L
V
G
E
A
V
K
A
I
Y
------
P
--
E
V
E
V
V
F
S
P
A
V
R
---
W
G
T
----
T
I
L
P
G
Q
A
I
-
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
D
I
A
S
N
V
F
T
S
D
P
F
-----------
Y
Q
Q
G
G
D
V
S
R
V
F
-
G
L
R
Y
V
L
D
P
D
A
-
P
T
G
E
R
V
R
E
V
E
V
--------
G
----
G
R
----
P
L
D
P
N
R
R
Y
L
A
A
A
Y
G
G
R
L
Q
R
V
G
E
-------
A
K
P
G
-------
Y
E
P
R
P
I
Y
E
V
L
A
E
Y
L
R
S
V
G
--
R
V
R
V
R
P
E
P
N
V
K
V
I
G
R
N
Y
R
L
P
E
V
T
G
--------------------------------
27
HHSearch
76.27
30%
-53
- C1 -
3GVE
3
NTPES_BACSU
A:
[8-340]
----------------------------------------------------
P
Q
V
H
L
S
I
L
A
T
T
D
I
H
A
N
M
--
M
D
---
Y
D
Y
--
Y
--
S
-
D
K
E
T
A
D
F
-----
G
L
A
R
T
A
Q
L
I
Q
K
H
R
E
Q
----
N
P
----
N
T
L
L
V
D
N
G
D
L
I
Q
G
N
---
P
L
G
E
Y
A
V
K
YQ
K
D
D
I
I
S
G
------
T
K
T
H
P
I
I
S
V
M
N
A
L
K
Y
D
A
G
T
L
G
N
H
E
F
-
N
Y
G
L
D
F
L
D
G
T
I
K
G
A
D
F
P
I
V
N
A
N
V
K
T
----
T
S
-
G
--
E
N
-
R
Y
T
-------
P
Y
V
I
N
E
K
TLID
E
NG
N
E
Q
K
----
V
K
V
G
Y
I
G
F
V
P
P
Q
I
M
T
W
D
K
--
K
N
L
E
G
Q
V
Q
V
Q
D
I
V
E
S
A
N
E
T
I
P
K
M
--
K
A
-
E
--
G
-
A
D
V
I
I
A
L
A
H
T
G
-
I
E
-
K
--
Q
A
Q
S
S
GAE------
N
---
A
V
F
D
--
L
A
T
K
T
--------------------
K
--
G
I
D
A
I
I
S
G
H
Q
H
----------------
G
L
--------------
F
P
S
-------------------
A
EYAGVAQFNVEKGT
I
-----
N
G
-
I
P
V
V
M
P
S
S
W
G
K
Y
L
G
V
I
D
L
K
L
-
E
-------
K
A
DG
S
W
K
V
A
D
S
K
G
S
--------
I
--
E
--
S
I---------
A
G--
N
V
T
S
-----------------------------
R
N
E
T
V
T
N
T
I
Q
Q
T
H
Q
N
T
L
E
--
Y
V
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------