@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0098: (2015-12-12 )
MRMQTKLIHGGINEDATTGAVSVPIYQTSTYRQDAIGRHKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYGGNFRLFNKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKEHNLLTIVDNTFATPYCQNPLLLGTDIVAHNGTKYLGGHSDVVAGLVTTNNEALAQEFDFFQNAIGGVLGLQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVERVYYPGLPTHPNHELAKAQMRGFSGMFSFTLKNDSEAVAFVESLKLFILGESLGGVESLVGIPALMTHACIPKAQREAAGIRDGLVRLSVGIEHEQDLLEDLDQAFAKIS
Atome Classification :
(31 SA)
.........10.....-...20........30.....--------..--------.40........50........60........70........-80.........90........100.......110-.......120.......130.......140.......150...-....160.-.-......170.......180.......190......-.200.....-..210.....-..220.--......230.......240.......250.......260.......270.......280.......290.......300..-.-.-.-..-310.......320....---...330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
M
Q
T
K
L
IHGGINEDA-TTG
A
V
S
V
P
I
Y
QTSTY
R
Q
D
AI--------GR--------HKGYEYSRSGN
P
T
R
F
A
L
E
E
L
I
A
D
L
EGGVK
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
QSG
D
H
V
L
LGDDVYGG
N
F
R
L
F
N
K
V
L
V
KN-G
L
S
C
T
I
ID
T
S
D
L
S
Q
I
K
K
A
IKPNT
K
A
L
Y
L
ETPSNPL
L
K
I
T
D
L
A
Q
-
C
A
S
V
A
-
K
E-H-
N
L
L
T
I
VDNTFATPYCQN
P
L
L
L
G
T
D
I
VAHNGTKYLG-GH
S
D
V
V
A
G
L
-
V
TTN
N
E
A
L
A
Q
-
E
F
D
F
F
Q
--
N
A
I
G
G
VLGL
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
EAHQKN
A
L
C
V
A
E
F
L
E
KHPK
V
E
R
V
YYPGLPTHP
N
H
E
L
A
K
A
Q
M
RGFS
G
M
F
S
F
T
LKND-
S
-
E
-
A
-
V
A
-
F
V
E
S
L
K
L
F
I
L
GESLG
G
V
---
E
S
L
VG
I
P
A
L
M
T
H
ACI
P
K
A
Q
R
E
A
AGIRD
G
L
V
R
L
S
VGIE
H
E
Q
D
L
L
E
D
L
D
Q
A
F
AKIS
26
PsiBlast_CBE
95.54
95%
-103
- C1 -
4L0O
2
METB_HELPY
C:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
-
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
-----------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
-
E
-
A
-
V
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
H
----------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-
1
PsiBlast_PDB
95.41
95%
-104
- C1 -
4L0O
2
METB_HELPY
H:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
-
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
----------------------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
-
E
-
A
-
V
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-
22
PsiBlast_CBE
94.09
95%
-105
- C1 -
4L0O
2
METB_HELPY
M:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
-
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
-----------
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
-
E
-
A
-
V
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
G
24
PsiBlast_CBE
93.94
95%
-104
- C1 -
4L0O
1
METB_HELPY
G:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
-
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
-
E
-
A
-
V
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-
23
PsiBlast_CBE
92.98
95%
-99
- C1 -
4L0O
1
METB_HELPY
K:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
-
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
R
--------
H
-
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
-
E
-
A
-
V
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
H
A
C
I
P
K
T
Q
R
E
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-
25
PsiBlast_CBE
92.95
95%
-102
- C1 -
4L0O
2
METB_HELPY
E:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
-
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
------------
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
-
E
-
A
-
V
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
-----------
A
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-
21
PsiBlast_CBE
92.61
95%
-102
- C1 -
4L0O
2
METB_HELPY
O:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
-
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
R
--------
H
K
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
-
E
-
A
-
V
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
------------
A
G
I
R
D
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-
27
PsiBlast_CBE
91.82
95%
-102
- C1 -
4L0O
2
METB_HELPY
A:
[1-379]
M
R
M
Q
T
K
L
I
H
G
G
I
S
E
D
A
-
T
T
G
A
V
S
V
P
I
Y
Q
T
S
T
Y
R
Q
D
A
I
--------
G
R
--------
H
K
G
Y
E
Y
S
R
S
G
N
P
T
R
F
A
L
E
E
L
I
A
D
L
E
G
G
V
K
G
F
A
F
A
S
G
L
A
G
I
H
-
A
-
V
F
S
L
L
Q
S
G
D
H
V
L
L
G
D
D
V
Y
G
G
T
F
R
L
F
N
Q
V
L
V
K
N
-
G
L
S
C
T
I
I
D
T
S
D
I
S
Q
I
K
K
A
I
K
P
N
T
K
A
L
Y
L
E
T
P
S
N
P
L
L
K
I
T
D
L
A
Q
-
C
A
S
V
A
-
K
D
-
H
-
G
L
L
T
I
V
D
N
T
F
A
T
P
Y
Y
Q
N
P
L
L
L
G
A
D
I
V
A
H
S
G
T
K
Y
L
G
-
G
H
S
D
V
V
A
G
L
-
V
T
T
N
N
E
A
L
A
Q
-
E
I
A
F
F
Q
--
N
A
I
G
G
V
L
G
P
Q
D
S
W
L
L
Q
R
G
I
K
T
L
G
L
R
M
E
A
H
Q
K
N
A
L
C
V
A
E
F
L
E
K
H
P
K
V
E
R
V
Y
Y
P
G
L
P
T
H
P
N
Y
E
L
A
K
K
Q
M
R
G
F
S
G
M
L
S
F
T
L
K
N
D
-
S
-
E
-
A
-
V
A
-
F
V
E
S
L
K
L
F
I
L
G
E
S
L
G
G
V
---
E
S
L
V
G
I
P
A
F
M
T
----------------
G
L
V
R
L
S
V
G
I
E
H
E
Q
D
L
L
E
D
L
E
Q
A
F
A
K
I
-
29
PsiBlast_CBE
87.82
54%
-97
- C1 -
4IY7
4
?
C:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
I
A
-
R
K
-
H
-
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
-
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
G
G
-
F
-
D
-
A
-
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
---
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
---
28
PsiBlast_CBE
87.47
54%
-96
- C1 -
4IY7
5
?
D:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
I
A
-
R
K
-
H
-
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
-
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
G
G
-
F
-
D
-
A
-
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
---
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
N
Q
-
30
PsiBlast_CBE
85.72
54%
-96
- C1 -
4IY7
6
?
B:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
I
A
-
R
K
-
H
-
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
-
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
G
G
-
F
-
D
-
A
-
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
---
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
---
4
PsiBlast_PDB
85.67
54%
-96
- C1 -
4IYO
8
?
A:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
I
A
-
R
K
-
H
-
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
-
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
G
G
-
F
-
D
-
A
-
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
---
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
---
3
PsiBlast_PDB
85.22
54%
-96
- C1 -
4IY7
8
?
A:
[15-393]
L
S
L
A
T
L
A
I
H
G
G
Q
S
P
D
P
-
S
T
G
A
V
M
P
P
I
Y
A
T
S
T
Y
A
Q
S
S
P
--------
G
E
--------
H
Q
G
F
E
Y
S
R
T
H
N
P
T
R
F
A
Y
E
R
C
V
A
A
L
E
G
G
T
R
A
F
A
F
A
S
G
M
A
A
T
S
-
T
-
V
M
E
L
L
D
A
G
S
H
V
V
A
M
D
D
L
Y
G
G
T
F
R
L
F
E
R
V
R
R
R
T
A
G
L
D
F
S
F
V
D
L
T
D
P
A
A
F
K
A
A
I
R
A
D
T
K
M
V
W
I
E
T
P
T
N
P
M
L
K
L
V
D
I
A
A
-
I
A
V
I
A
-
R
K
-
H
-
G
L
L
T
V
V
D
N
T
F
A
S
P
M
L
Q
R
P
L
S
L
G
A
D
L
V
V
H
S
A
T
K
Y
L
N
-
G
H
S
D
M
V
G
G
I
A
V
V
G
D
N
A
E
L
A
E
-
Q
M
A
F
L
Q
--
N
S
I
G
G
V
Q
G
P
F
D
S
F
L
A
L
R
G
L
K
T
L
P
L
R
M
R
A
H
C
E
N
A
L
A
L
A
Q
W
L
E
T
H
P
A
I
E
K
V
I
Y
P
G
L
A
S
H
P
Q
H
V
L
A
K
R
Q
M
S
G
F
G
G
I
V
S
I
V
L
K
G
G
-
F
-
D
-
A
-
A
K
R
F
C
E
K
T
E
L
F
T
L
A
E
S
L
G
G
V
---
E
S
L
V
N
H
P
A
V
M
T
H
A
S
I
P
V
A
R
R
E
Q
L
G
I
S
D
A
L
V
R
L
S
V
G
I
E
D
L
G
D
L
R
G
D
L
E
R
A
L
V
---
10
PsiBlast_PDB
81.87
42%
-95
- C1 -
4OMA
6
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
-
E
-
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
102
HHSearch
81.27
49%
-100
- C1 -
3COG
5
CGL_HUMAN
A:
[19-398]
--
F
A
T
Q
A
I
H
V
G
Q
D
P
E
Q
W
T
S
R
A
V
V
P
P
I
S
L
S
T
T
F
K
Q
------------------------------
G
N
P
T
R
N
C
L
E
K
A
V
A
A
L
D
G
A
K
Y
C
L
A
F
A
S
G
L
A
A
T
V
T
I
-
T
-
H
L
L
K
A
G
D
Q
I
I
C
M
D
D
V
Y
G
G
T
N
R
Y
F
R
Q
V
A
S
E
F
-
G
L
K
I
S
F
V
D
C
S
K
I
K
L
L
E
A
A
I
T
P
E
T
K
L
V
W
I
E
T
P
T
N
P
T
Q
K
V
I
D
I
E
G
-
C
A
H
I
V
-
H
K
-
H
G
D
I
I
L
V
V
D
N
T
F
M
S
P
Y
F
Q
R
P
L
A
L
G
A
D
I
S
M
Y
S
A
T
K
Y
M
N
-
G
H
S
D
V
V
M
G
L
-
V
S
V
N
C
E
S
L
H
N
-
R
L
R
F
L
Q
--
N
S
L
G
A
V
P
S
P
I
D
C
Y
L
C
N
R
G
L
K
T
L
H
V
R
M
E
K
H
F
K
N
G
M
A
V
A
Q
F
L
E
S
N
P
W
V
E
K
V
I
Y
P
G
L
P
S
H
P
Q
H
E
L
V
K
R
Q
C
T
G
C
T
G
M
V
T
F
Y
I
K
G
T
-
L
Q
H
-
A
-
E
I
-
F
L
K
N
L
K
L
F
T
L
A
E
S
L
G
G
F
---
E
S
L
A
E
L
P
A
I
M
T
H
A
S
V
L
K
N
D
R
D
V
L
G
I
S
D
T
L
I
R
L
S
V
G
L
E
D
E
E
D
L
L
E
D
L
D
Q
A
L
K
A
A
H
12
PsiBlast_PDB
80.63
41%
-94
- C1 -
3JWA
6
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
-
E
-
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
13
PsiBlast_PDB
79.97
41%
-94
- C1 -
3JWB
4
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
-
E
-
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
11
PsiBlast_PDB
79.92
42%
-95
- C1 -
4HF8
5
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
-
E
-
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
14
PsiBlast_PDB
79.80
41%
-96
- C1 -
3JW9
2
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F
A
LE
E
S
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
-
E
-
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
R
L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
15
PsiBlast_PDB
79.61
41%
-97
- C1 -
2RFV
1
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F-----
G
Y
I
Y
T
R
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
R
F
V
D
A
A
K
P
E
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I
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A
A
M
R
P
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T
K
V
V
Y
I
E
T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
S
P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
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M
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R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
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L
G
Q
R
Q
M
S
L
P
G
G
I
I
S
F
E
I
A
G
G
-
L
-
E
-
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
I
T
D
G
L
I
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L
S
V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
104
HHSearch
77.87
42%
-93
- C1 -
1IBJ
4
METC_ARATH
A:
[86-462]
-
S
V
S
T
L
L
V
N
L
D
N
K
F
D
--
P
F
D
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
--------
I
E
--------
N
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
A
V
-
T
H
-
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
-
G
V
V
V
K
R
V
N
T
T
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
-
I
S
E
M
A
-
H
A
-
Q
-
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
-
G
H
S
D
V
M
A
G
V
-
L
A
V
K
G
E
K
L
A
K
-
E
V
Y
F
L
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
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H
P
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H
L
H
F
S
Q
A
K
G
A
G
S
V
F
S
F
I
T
G
S
V
-
A
-
L
-
S
-
K
H
-
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
---
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
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V
R
E
A
R
G
L
T
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D
L
V
R
I
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A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
P
18
PsiBlast_PDB
76.27
41%
-97
- C1 -
3MKJ
1
?
A:
[11-395]
----
T
Q
I
V
H
A
G
Q
Q
P
D
P
-
S
T
G
A
L
S
T
P
I
F
Q
T
S
T
F
V
F
D
S
A
--------
E
Q
G
A
A
R
F-----------
L
G
N
P
T
T
D
A
L
E
K
K
L
A
V
L
E
R
G
E
A
G
L
A
T
A
S
G
I
S
A
I
T
-
T
T
L
L
T
L
C
Q
Q
G
D
H
I
V
S
A
S
A
I
Y
G
C
T
H
A
F
L
S
H
S
M
P
K
F
-
G
I
N
V
S
F
V
D
A
A
K
P
E
E
I
R
A
A
M
R
P
E
T
K
V
V
Y
I
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T
P
A
N
P
T
L
S
L
V
D
I
E
T
-
V
A
G
I
A
-
H
Q
-
Q
-
G
A
L
L
V
V
D
N
T
F
M
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P
Y
C
Q
Q
P
L
Q
L
G
A
D
I
V
V
H
S
V
T
K
Y
I
N
-
G
H
G
D
V
I
G
G
I
-
I
V
G
K
Q
E
F
I
D
Q
A
R
F
V
G
L
K
--
D
I
T
G
G
C
M
S
P
F
N
A
W
L
T
L
R
G
V
K
T
L
G
I
R
M
E
R
H
C
E
N
A
L
K
I
A
R
F
L
E
G
H
P
S
I
T
R
V
Y
Y
P
G
L
S
S
H
P
Q
Y
E
L
G
Q
R
Q
M
S
L
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G
G
I
I
S
F
E
I
A
G
G
-
L
-
E
-
A
G
R
R
-
M
I
N
S
V
E
L
C
L
L
A
V
S
L
G
D
T
---
E
T
L
I
Q
H
P
A
S
M
T
H
S
P
V
A
P
E
E
R
L
K
A
G
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D
G
L
I
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L
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V
G
L
E
D
P
E
D
I
I
N
D
L
E
H
A
I
R
K
A
T
39
PsiBlast_CBE
76.10
43%
-92
- C1 -
1E5F
5
?
B:
[6-392]
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
QQGGNRFA
G
Q
--------
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
I
P
G
E
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K
K
H
M
K
P
N
T
K
I
V
Y
F
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T
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A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
-
S
Q
-
E
-
G
V
L
V
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A
D
N
T
F
C
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P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
T
D
V
V
A
G
L
-
I
C
G
K
A
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L
L
Q
Q
I
R
M
V
G
I
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--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
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E
N
A
M
K
V
A
E
Y
L
K
S
H
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A
V
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K
V
Y
Y
P
G
F
E
D
H
E
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A
K
K
Q
M
R
M
Y
G
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M
I
T
F
I
L
K
S
G
-
F
-
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G
A
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K
K
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L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
105
HHSearch
75.66
44%
-91
- C1 -
1E5E
5
?
A:
[7-395]
-
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
A
T
-
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
-
V
C
K
D
A
-
H
S
Q
E
-
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
T
D
V
V
A
G
L
-
I
C
G
K
A
-
D
L
L
Q
-
Q
I
R
M
V
G
IK
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
F
E
-
G
-
A
-
K
K
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L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
40
PsiBlast_CBE
75.40
43%
-91
- C1 -
1E5F
6
?
A:
[6-392]
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
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P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
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T
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A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
-
S
Q
-
E
-
G
V
L
V
I
A
D
N
T
F
C
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P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
T
D
V
V
A
G
L
-
I
C
G
K
A
D
L
L
Q
Q
I
R
M
V
G
I
K
--
D
I
T
G
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V
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P
H
D
A
W
L
I
T
R
G
L
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T
L
N
I
R
M
K
A
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E
N
A
M
K
V
A
E
Y
L
K
S
H
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A
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V
Y
Y
P
G
F
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D
H
E
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H
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I
A
K
K
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M
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M
Y
G
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M
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F
I
L
K
S
G
-
F
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A
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K
K
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L
L
D
N
L
K
L
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T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
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M
T
H
A
V
V
P
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E
E
R
E
A
A
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I
T
D
G
M
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R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
20
PsiBlast_PDB
75.40
43%
-91
- C1 -
1E5E
5
?
A:
[6-392]
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
Q
Q
G
G
N
R
F
A
G
Q
--------
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
-
S
Q
-
E
-
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
T
D
V
V
A
G
L
-
I
C
G
K
A
D
L
L
Q
Q
I
R
M
V
G
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
-
F
-
E
G
A
-
K
K
-
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
41
PsiBlast_CBE
75.39
43%
-91
- C1 -
1E5E
6
?
B:
[6-392]
M
T
P
A
T
A
C
I
H
A
N
P
Q
K
D
--
Q
F
G
A
A
I
P
P
I
Y
Q
T
S
T
F
V
F
D
N
C
QQGGNRFA
G
Q
--------
E
S
G
Y
I
Y
T
R
L
G
N
P
T
V
S
N
L
E
G
K
I
A
F
L
E
K
T
E
A
C
V
A
T
S
S
G
M
G
A
I
A
-
A
T
V
L
T
I
L
K
A
G
D
H
L
I
S
D
E
C
L
Y
G
C
T
H
A
L
F
E
H
A
L
T
K
F
-
G
I
Q
V
D
F
I
N
T
A
I
P
G
E
V
K
K
H
M
K
P
N
T
K
I
V
Y
F
E
T
P
A
N
P
T
L
K
I
I
D
M
E
R
V
C
K
D
A
H
-
S
Q
-
E
-
G
V
L
V
I
A
D
N
T
F
C
S
P
M
I
T
N
P
V
D
F
G
V
D
V
V
V
H
S
A
T
K
Y
I
N
-
G
H
T
D
V
V
A
G
L
-
I
C
G
K
A
D
L
L
Q
Q
I
R
M
V
G
I
K
--
D
I
T
G
S
V
I
S
P
H
D
A
W
L
I
T
R
G
L
S
T
L
N
I
R
M
K
A
E
S
E
N
A
M
K
V
A
E
Y
L
K
S
H
P
A
V
E
K
V
Y
Y
P
G
F
E
D
H
E
G
H
D
I
A
K
K
Q
M
R
M
Y
G
S
M
I
T
F
I
L
K
S
G
-
F
-
E
G
A
-
K
K
-
L
L
D
N
L
K
L
I
T
L
A
V
S
L
G
G
C
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
V
V
P
K
E
E
R
E
A
A
G
I
T
D
G
M
I
R
L
S
V
G
I
E
D
A
D
E
L
I
A
D
F
K
Q
G
L
D
A
L
L
9
PsiBlast_PDB
75.25
43%
-94
- C1 -
1IBJ
4
METC_ARATH
A:
[103-459]
--------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
--------
I
E
--------
N
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
-
G
V
V
V
K
R
V
N
T
T
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
-
I
S
E
M
A
-
H
A
-
Q
-
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
-
G
H
S
D
V
M
A
G
V
-
L
A
V
K
G
E
K
L
A
K
-
E
V
Y
F
L
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
G
A
G
S
V
F
S
F
I
T
G
S
V
-
A
-
L
-
S
-
K
H
-
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
---
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
P
35
PsiBlast_CBE
73.23
43%
-93
- C1 -
1IBJ
3
METC_ARATH
C:
[103-459]
--------------------
A
M
S
T
P
L
Y
Q
T
A
T
F
K
Q
P
S
A
--------
I
E
--------
N
G
P
Y
D
Y
T
R
S
G
N
P
T
R
D
A
L
E
S
L
L
A
K
L
D
K
A
D
R
A
F
C
F
T
S
G
M
A
A
L
S
-
A
-
V
T
H
L
I
K
N
G
E
E
I
V
A
G
D
D
V
Y
G
G
S
D
R
L
L
S
Q
V
V
P
R
S
-
G
V
V
V
K
R
V
N
T
T
K
L
D
E
V
A
A
A
I
G
P
Q
T
K
L
V
W
L
E
S
P
T
N
P
R
Q
Q
I
S
D
I
R
K
-
I
S
E
M
A
-
H
A
-
Q
-
G
A
L
V
L
V
D
N
S
I
M
S
P
V
L
S
R
P
L
E
L
G
A
D
I
V
M
H
S
A
T
K
F
I
A
-
G
H
S
D
V
M
A
G
V
-
L
A
V
K
G
E
K
L
A
K
-
E
V
Y
F
L
Q
--
N
S
E
G
S
G
L
A
P
F
D
C
W
L
C
L
R
G
I
K
T
M
A
L
R
I
E
K
Q
Q
E
N
A
R
K
I
A
M
Y
L
S
S
H
P
R
V
K
K
V
Y
Y
A
G
L
P
D
H
P
G
H
H
L
H
F
S
Q
A
K
G
A
G
S
V
F
S
F
I
T
G
S
V
-
A
-
L
-
S
-
K
H
-
L
V
E
T
T
K
Y
F
S
I
A
V
S
F
G
S
V
---
K
S
L
I
S
M
P
C
F
M
S
H
A
S
I
P
A
E
V
R
E
A
R
G
L
T
E
D
L
V
R
I
S
A
G
I
E
D
V
D
D
L
I
S
D
L
D
I
A
F
K
T
F
P
88
PsiBlast_CBE
72.39
45%
-101
- C1 -
1PFF
18
?
A:
[2-327]
----------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
-
A
S
V
W
T
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
-
G
V
E
V
D
F
I
D
M
A
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
-
A
V
K
Q
A
R
K
Q
-
K
-
D
I
L
V
I
V
D
N
T
F
A
S
P
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
-
G
H
T
D
V
V
A
G
L
-
V
C
S
R
A
D
I
I
A
K
V
K
S
Q
G
I
K
--
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
K
M
F
G
S
M
I
A
F
D
V
D
G
L
-
E
-
K
-
A
-
K
K
-
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
---
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
L
115
HHSearch
69.16
43%
-94
- C1 -
1PFF
18
?
A:
[2-330]
----------------------------------------------------------------------
A
L
E
G
K
I
A
K
L
E
H
A
E
A
C
A
A
T
A
S
G
M
G
A
I
A
A
S
-
V
W
T
F
L
K
A
G
D
H
L
I
S
D
D
C
L
Y
G
C
T
H
A
L
F
E
H
Q
L
R
K
F
-
G
V
E
V
D
F
I
D
M
A
V
P
G
N
I
E
K
H
L
K
P
N
T
R
I
V
Y
F
E
T
P
A
N
P
T
L
K
V
I
D
I
E
D
-
A
V
K
Q
A
-
R
K
Q
K
-
D
I
L
V
I
V
D
N
T
F
A
S
P
I
L
T
N
P
L
D
L
G
V
D
I
V
V
H
S
A
T
K
Y
I
N
G
H
T
D
-
V
V
A
G
L
-
V
C
S
R
A
-
D
I
I
A
-
K
V
K
S
Q
G
IK
D
I
T
G
A
I
I
S
P
H
D
A
W
L
I
T
R
G
T
L
T
L
D
M
R
V
K
R
A
A
E
N
A
Q
K
V
A
E
F
L
H
E
H
K
A
V
K
K
V
Y
Y
P
G
L
P
D
H
P
G
H
E
I
A
K
K
Q
M
K
M
F
G
S
M
I
A
F
D
V
D
G
L
-
E
-
K
-
A
-
K
K
----
V
L
D
N
C
H
V
V
S
L
A
V
S
L
G
G
P
E
S
L
I
Q
H
P
A
S
M
T
H
A
G
V
P
K
E
E
R
E
A
A
G
L
T
D
N
L
I
R
L
S
V
G
C
E
N
V
Q
D
I
I
D
D
L
K
Q
A
L
D
L
V
L