@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0113: (2015-12-12 )
MSAELIAVYKDEQIIDLESAKVLGLSDGIKALKGTEPIYFDDSPLALEVIRHSCAHLLAQSLKALYPDAKFFVGPVVEEGFYYDFKTTSKISEEDLPKIEAKMKEFAKSKLAITKETLTREQALERFKGDELKHAVMSKISGDIFGVYQQGEFEDLCKGPHLPNTRFLNHFKLTKLAGAYLGGDENNEMLIRIYGIAFATKEGLKDYLFQIEEAKKRDHRKLGVELGLFSFDDEIGAGLPLWLPKGARLRKRIEDLLSQALLLRGYEPVKGPEILKSDVWKISGHYDNYKENMYFTTIDEQEYGIKPMNCVGHIKVYQSALHSYRDLPLRFYEYGVVHRHEKSGVLHGLLRVREFTQDDAHIFCSFEQIQSEVSAILDFTHKIMQAFGFSYEMELSTRPAKSIGDDKVWEKATNALKEALKEHRIDYKIDEGGGAFYGPKIDIKITDALKRKWQCGTIQVDMNLPERFKLAFTNEYNHAEQPVMIHRAILGSFERFIAILSEHFGGNFPFFVAPTQIALIPINEEHHVFALKLKEALKKCDIFVEVLDKNDSLNKKVRLAEKQKIPMILVLGNEEVETEILSIRDREKQAQYKMPLKEFLNMVESKMQEVSF
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.....--..--130.......--140-..-......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......-250.......260........270.......280.......290..-..-.-..300...-....310.......320.......330.......340.......350.......360.......370.......380..-..-...----390--........----.400--.........410.......420.......430.......440.......450.......460.......470-.......480.......490.......500.......510.......520..-.---.-------...530.......--------------540---------....-..-.550.......560.......570.......580.......590........600........610
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
A
E
L
I
A
V
YKD
E
Q
I
I
DLES
A
K
V
LGLSD
G
I
K
ALKGTE
P
I
Y
FDDS
P
L
A
L
E
V
I
R
H
S
C
A
H
L
L
A
Q
S
L
K
A
LYPDA
K
F
F
V
G
PVVEE
G
F
Y
Y
DFKTTSKISEED
L
P
K
I
E
A
K
M
K
E
F
A
K
S
K
L
A
I
T
K
E
T
L
T
R
E
Q
A
L
E
R
F--K
G
--
D
E
L
K
H
A
V
M
S
K
--IS--G
D
-
I
F
G
V
YQQG
E
F
E
D
L
CKGPHLPNT
R
F
L
N
H
F
K
L
T
K
L
A
G
A
YLGGDEN
N
E
M
L
I
R
I
Y
G
I
A
F
A
T
K
E
G
L
K
D
Y
L
F
Q
I
E
E
A
K
K
R
D
H
R
K
LG
V
E
LG
L
F
SFDDEIGAGLPLWLPK
G
A
R
L
-
R
K
R
I
E
D
L
L
S
Q
A
L
-
L
LRGYEPVK
G
P
E
I
L
K
SD
V
W
K
ISGHYDNYKE
N
M
Y
-
F
T
-T-IDEQEYGI-KP
M
N
C
V
G
H
I
K
V
Y
Q
S
A
L
H
S
YRDL
P
L
R
F
Y
EYGVVHRHEKS
G
V
L
H
G
L
L
R
V
R
E
F
TQDD
A
H
I
F
C
S
F
E
Q
I
Q
S
E
V
S
A
I
L
D
F
T
H
K
I
M
-
Q
A
-FG
F
----
S
----
Y
E
M
E
LSTR----PA----KSIG
D
D
K
V
W
E
K
A
T
N
A
L
K
E
A
L
K
EHR
I
D
Y
K
IDEGGGAFYG
P
K
I
D
I
K
I
T
D
A
L
KRKWQC
G
T
I
Q
V
DMNLP
E
R
F
K
L
A
F
-TNEYNHAEQ
P
V
M
I
H
R
A
I
L
G
S
F
E
R
F
I
A
I
L
S
E
HFGGNF
P
F
F
VAP
T
Q
I
A
L
I
P
INE-E---H-------
H
V
F
A
L
K
L
K
E
A
L
K
K
--------------
C
D
I
---------
F
V
E
V
-LD-KNDSLN
K
K
VRLAEKQKI
P
M
I
L
V
LGNE
E
V
E
T
E
I
L
S
I
R
D
R
E
K
Q
A
Q
-YKM
P
L
K
E
F
L
-
N
M
V
E
S
K
M
Q
EVSF
53
HHSearch
92.75
41%
-94
* C1 *
1QF6
2
SYT_ECOLI
A:
[33-635]
--
K
A
C
I
A
G
R
V
N
G
E
L
V
D
A
C
D
L
--------
I
E
N
D
A
Q
L
S
I
I
T
A
K
D
-
E
E
G
L
E
I
I
R
H
S
C
A
H
L
L
G
H
A
I
K
Q
L
W
P
H
T
K
M
A
I
G
P
V
I
D
N
G
F
Y
Y
D
V
D
L
D
R
T
L
T
Q
E
D
V
E
A
L
E
K
R
M
H
E
L
A
E
K
N
Y
D
V
I
K
K
K
V
S
W
H
E
A
R
E
T
F
--
A
N
R
G
E
S
Y
K
V
S
I
L
D
E
--
N
I
AH
D
D
-
K
P
G
L
Y
F
H
E
E
Y
V
D
M
C
R
G
P
H
V
P
N
M
R
F
C
H
H
F
K
L
M
K
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
W
A
D
K
K
A
L
N
A
Y
L
Q
R
L
E
E
A
A
K
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
1
PsiBlast_PDB
91.39
42%
-93
- C1 -
1QF6
2
SYT_ECOLI
A:
[67-637]
---------------------------------------------
G
L
E
I
I
R
H
S
C
A
H
L
L
G
H
A
I
K
Q
L
W
P
H
T
K
M
A
I
G
P
V
I
D
N
G
F
Y
Y
D
V
D
L
D
R
T
L
T
Q
E
D
V
E
A
L
E
K
R
M
H
E
L
A
E
K
N
Y
D
V
I
K
K
K
V
S
W
H
E
A
R
E
T
F
A
N
R
G
--
E
S
Y
K
V
S
I
L
D
E
NI
A
H
--
D
D
-
K
P
G
L
Y
F
H
E
E
Y
V
D
M
C
R
G
P
H
V
P
N
M
R
F
C
H
H
F
K
L
M
K
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
W
A
D
K
K
A
L
N
A
Y
L
Q
R
L
E
E
A
A
K
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
54
HHSearch
90.27
40%
-92
- C1 -
1NYR
4
SYT_STAAW
A:
[36-642]
---
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
--------
L
E
T
D
G
S
I
E
I
V
T
P
G
S
-
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
--
S
N
--
D
E
Y
K
L
E
L
I
D
A
--
I
P
E-
D
E
-
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
-
R
R
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Y
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V
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Y
D
H
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Y
T
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L
A
N
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L
Y
K
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G
H
W
D
H
Y
Q
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D
M
F
-
P
P
M
Q
L
D
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S
M
V
L
-
R
P
M
N
C
P
H
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M
M
I
Y
A
N
K
P
H
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P
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A
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A
V
S
G
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R
P
D
Q
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K
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F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
----
E
D
---
Y
S
F
R
L
S
Y
R
D
P
ED
K
E
----
K
Y
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
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Q
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K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
-
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
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F
V
A
F
L
T
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T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
D
L
---
H
-------
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
G
V
---------
R
V
S
I
-
D
D
-
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
-
W
N
L
V
D
E
I
R
L
K
K
H
3
PsiBlast_PDB
89.52
42%
-95
- C1 -
1NYR
4
SYT_STAAW
A:
[69-637]
---------------------------------------------
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
--
S
N
--
D
E
Y
K
L
E
L
I
D
A
--
I
P
--
E
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
-
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
-
Q
-
L
D
E
T
E
S
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
E---
D
----
Y
S
F
R
L
S
Y
R
----
D
P
EDKE
K
Y
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
-
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
-
D
L--
H
-------
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
G
V
---------
R
V
S
I
-
D
D
-
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
K
K
H
R
2
PsiBlast_PDB
89.22
42%
-97
- C1 -
1NYQ
2
SYT_STAAW
A:
[69-637]
---------------------------------------------
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
--
S
N
--
D
E
Y
K
L
E
L
I
D
A
--
I
P
--
E
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
-
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
-
Q
-
L
D
E
T
E
S
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
E---
D
----
Y
S
F
R
L
S
Y
R
----
D
P
EDKE
K
Y
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
-
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
-
D
L--
H
-------
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
G
V
---------
R
V
S
I
-
D
D
-
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
K
K
H
R
22
PsiBlast_CBE
86.95
42%
-94
- C1 -
1NYQ
2
SYT_STAAW
B:
[69-637]
---------------------------------------------
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
--
S
N
--
D
E
Y
K
L
E
L
I
D
A
--
I
P
--
E
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
-
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
-
Q
-
L
D
E
T
E
S
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
E---
D
----
Y
S
F
R
L
S
Y
R
----
D
P
EDKE
K
Y
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
-
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
-
D
L--
H
-------
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
G
V
---------
R
V
S
I
-
D
D
-
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
K
K
H
R
21
PsiBlast_CBE
85.73
42%
-94
- C1 -
1NYR
3
SYT_STAAW
B:
[69-637]
---------------------------------------------
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
------------
E
L
I
D
A
--
I
P
--
E
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
-
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
-
Q
-
L
D
E
T
E
S
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
E---
D
----
Y
S
F
R
L
S
Y
R
----
D
P
EDKE
K
Y
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
-
I
G
Q
D
G
E
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
-
D
L--
H
-------
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
G
V
---------
R
V
S
I
-
D
D
-
R
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
K
K
H
R
24
PsiBlast_CBE
75.18
41%
-95
- C1 -
4HWR
2
SYT_ECOLI
B:
[3-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
40
PsiBlast_CBE
75.09
41%
-93
- C1 -
1EVK
2
SYT_ECOLI
B:
[1-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
11
PsiBlast_PDB
74.89
41%
-92
- C1 -
1EVL
2
SYT_ECOLI
A:
[1-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
9
PsiBlast_PDB
74.74
41%
-92
- C1 -
4P3P
6
SYT_ECOLI
A:
[2-397]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
56
HHSearch
74.70
41%
-92
- C1 -
1EVL
2
SYT_ECOLI
A:
[1-395]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
39
PsiBlast_CBE
74.54
41%
-91
- C1 -
1EVL
2
SYT_ECOLI
B:
[1-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
12
PsiBlast_PDB
74.52
41%
-93
- C1 -
1FYF
2
SYT_ECOLI
A:
[1-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
27
PsiBlast_CBE
74.41
41%
-92
- C1 -
4P3P
7
SYT_ECOLI
B:
[2-397]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
10
PsiBlast_PDB
74.32
41%
-91
- C1 -
1EVK
1
SYT_ECOLI
A:
[1-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
7
PsiBlast_PDB
74.06
41%
-91
- C1 -
4HWS
2
SYT_ECOLI
A:
[3-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
36
PsiBlast_CBE
74.00
41%
-94
- C1 -
1FYF
2
SYT_ECOLI
B:
[1-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
37
PsiBlast_CBE
73.93
41%
-91
- C1 -
1EVL
2
SYT_ECOLI
D:
[1-396]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
6
PsiBlast_PDB
73.79
41%
-96
- C1 -
4HWR
2
SYT_ECOLI
A:
[3-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
23
PsiBlast_CBE
73.73
41%
-92
- C1 -
4HWS
2
SYT_ECOLI
B:
[3-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
8
PsiBlast_PDB
73.69
41%
-91
- C1 -
4P3O
6
SYT_ECOLI
A:
[2-397]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
28
PsiBlast_CBE
73.47
41%
-90
- C1 -
4P3O
7
SYT_ECOLI
B:
[2-397]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
26
PsiBlast_CBE
73.37
41%
-93
- C1 -
4HWO
2
SYT_ECOLI
B:
[3-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
5
PsiBlast_PDB
73.35
41%
-90
- C1 -
4HWP
2
SYT_ECOLI
A:
[3-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
41
PsiBlast_CBE
73.29
40%
-97
- C1 -
4HWT
2
SYTC_HUMAN
B:
[3-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
R
D
Q
E
L
Y
F
F
H
-
E
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
-
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
-
S
F
-
E
-
V
E
K
E
L
F
A
L
-
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
----
P
E
----
K
F
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
P
-
T
---
C
-------
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
K
F
---------
M
A
D
I
D
L
D
-
P
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
T
R
D
N
K
V
H
-
G
E
R
T
I
S
E
T
I
-
E
R
L
Q
Q
L
K
E
F
R
S
K
25
PsiBlast_CBE
73.25
41%
-91
- C1 -
4HWP
2
SYT_ECOLI
B:
[3-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
4
PsiBlast_PDB
73.25
41%
-90
- C1 -
4HWO
2
SYT_ECOLI
A:
[3-398]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
E
-
A
P
G
M
V
F
W
H
N
D
G
W
T
I
-
F
R
E
L
E
V
F
V
R
S
K
L
-
K
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
-
T
T
-
S
-
S
E
N
R
E
Y
C
I
-
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
----
P
E
----
K
R
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
-
V
G
E
D
N
E
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
D
-
S
---
Q
-------
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
G
I
---------
R
V
K
A
-
D
L
-
R
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
-
E
K
L
Q
Q
E
I
R
S
R
S
L
14
PsiBlast_PDB
71.62
40%
-96
- C1 -
4HWT
2
SYTC_HUMAN
A:
[3-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
R
D
Q
E
L
Y
F
F
H
-
E
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
-
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
-
S
F
-
E
-
V
E
K
E
L
F
A
L
-
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
----
P
E
----
K
F
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
----
D
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
P
-
T
---
C
-------
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
K
F
---------
M
A
D
I
D
L
D
-
P
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
T
R
D
N
K
V
H
-
G
E
R
T
I
S
E
T
I
-
E
R
L
Q
Q
L
K
E
F
R
S
K
57
HHSearch
71.22
36%
-90
- C1 -
3UH0
3
SYTM_YEAST
A:
[35-459]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
T
S
M
V
S
Q
R
Q
D
L
F
M
T
D
P
-
L
S
P
G
S
M
F
F
L
P
N
G
A
K
I
-
F
N
K
L
I
E
F
M
K
L
Q
Q
K
F
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
-
K
V
E
T
-----
E
Y
G
L
-
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
-
N
K
I
F
P
F
----
V
AESN
Y
F
I
N
F
S
T
R
----
P
D
----
H
F
I
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
-
K
D
Q
D
N
S
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
T
-
K
N
V
Q
Q
-------
L
D
M
C
T
A
L
Q
K
K
L
R
N
ELEADDMEPVPLN
D
W
H
F
---------
N
V
D
L
-
D
I
-
R
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
E
R
D
N
R
K
S
F
E
K
L
T
M
S
Q
I
W
-
E
K
F
I
E
L
E
K
N
Y
K
-
18
PsiBlast_PDB
62.06
37%
-73
- C1 -
3UH0
3
SYTM_YEAST
A:
[50-441]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
S
P
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
K
-
F
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
K
V
E
-
T
-----
E
Y
G
L
-
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
N
K
I
-
F
P
F
VAES
N
----
Y
F
I
N
F
S
T
R
----
P
D
----
H
F
I
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
-
K
D
Q
D
N
S
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
T
-
K
---
N
V
Q
Q
L
D
M
C
T
A
L
Q
K
K
L
R
N
E
L
E
A
--------------
D
D
M
EPVPLN
D
W
H
F
N
V
D
-
L
D
I
R
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
E
R
D
N
R
K
S
-
F
E
K
L
T
M
S
Q
I
-
W
E
K
F
I
E
L
E
K
N
Y
K