@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0142: (2015-12-12 )
MLTIKDIHALEVMDSRGNPTIQASVILSDNTKASAIVPSGASTGKREALELRDNDKTRFLGKGVLRACENVNSVIKHHLIGLEATNQAFVDERLRALDGTPNYANLGANAVLGVSMALARASAKALNLPLYRYLGGANALTLPVPMLNIINGGTHANNSIDFQEYMIMPLGFESFKEALRASAEVYHTLKKLLDEKNQLTSVGDEGGFAPNFNNNVEPLEIISQAIEKAGYKLGEEIALALDVASSELVDEHFNYHLKGENKILDSHELVAYYKELVAKYPIVSIEDGLSEDDWEGWAFLSKELGRQIQLVGDDLFVTNASILQKGIEKNVANAILIKPNQIGTISETLETIRLAKHHAYQCVISHRSGESEDSFIADFAVALNTGEIKTGSTARSERIAKYNRLLEIEHELKGGIYIGKELFKHG
Atome Classification :
(54 SA)
.........10........20........30----------........40-........50........60........70........80-.--........90........100.......110.......120.......130.---..---.-----.-----.-----.---140.......150.......160.......170.......180......----.190....--.--..--200-........210.---...----.-..220.......230....-...240.......-250--.---..-.-..--------.-------.--------260-.----........270........280.......290.......300.......310...-....320.......330.......340.......350.......360.......370.......380.......390.......400.......410-...-....420....--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
T
I
K
D
I
H
A
L
E
V
MDSRGNP
T
I
Q
A
S
V
I
L
SDNT----------K
A
S
A
I
VPSGA-STGKR
E
A
L
E
LRDND
K
T
R
F
L
G
K
G
V
L
R
A
C
E
N
V
N
S
V
I
K
H
H
L
I--G--LEAT
N
Q
A
F
V
D
E
R
L
R
ALDGTP
N
Y
A
NLG
A
N
A
V
L
G
V
S
M
A
L
A
R
ASAKALN
L
P
L
Y
R
Y---LG---G-----A-----
N
-----
A
---
L
T
LP
V
P
M
L
N
IINGGTHANNSI
D
F
Q
E
Y
M
I
MPL
G
F
E
S
F
K
E
A
L
R
A
S
A
E
V
Y
H
T
----
L
K
K
L
LDEK--N--QL--TS--VGDEGGFAPNFN---NNV----
E
-
P
L
E
I
I
S
Q
A
I
E
K
A
G
Y
KL
G
E
E
-
I
A
L
A
L
DV
A
S
S
E
L
V
-
D
E
---H---F
N
-
Y
-
H
L--------K-------G--------E---N----KIL
D
S
H
E
L
V
-
A
Y
Y
K
E
L
V
A
KYP
I
V
S
IEDGLSEDDW
E
G
W
A
F
L
S
K
ELG
R
Q
I
Q
LVGDD
L
-
F
VT
N
A
S
I
L
Q
K
G
I
E
KNVA
N
A
I
L
IKPNQIG
T
I
S
E
T
L
E
T
I
R
L
A
K
H
H
A
Y
Q
C
V
I
SHRSGESE
D
S
F
I
A
D
F
A
V
A
LNTGEIKTGS
T
A
R
S
E
R
I
A
K
Y
N
R
L
L
E
I
E
H
EL-KG
G
-
I
Y
I
G
K
E
L
FKHG--
27
PsiBlast_CBE
94.04
58%
-92
- C1 -
4YWS
1
ENO_CHLAA
B:
[5-425]
---
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
-----------
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
-----
V
-----
Y
-----
A
---
H
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
T
---
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
----------------
E
G
G
F
A
P
S
L
----
T
N
D
----
A
-
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
-------------
Y
-
H
L
--------
K
----------------
E
---
G
----
R
--
S
S
A
E
M
V
-
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
-
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
-
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
-
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
-
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
-
R
Y
A
G
R
S
A
F
K
V
---
21
PsiBlast_CBE
93.64
63%
-73
- C1 -
3QN3
4
ENO_CAMJE
D:
[4-417]
M
L
V
I
E
D
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
----------
V
G
A
A
I
V
P
S
G
A
-
S
T
G
S
K
E
A
L
E
L
R
D
N
D
E
-
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
A
D
E
I
L
--
G
--
L
D
A
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
---
G
-----
A
-----
N
-----
A
---
S
I
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
----
L
K
K
E
L
A
N
S
--
G
--
H
S
--
T
A
--
L
G
D
E
G
G
F
A
P
N
L
A
---
N
N
T
----
E
-
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
-
V
K
I
A
L
D
V
A
S
T
E
F
F
-
K
D
---
G
----
K
-
Y
-
H
M
--------
E
-------
G
-----------------
K
A
F
S
S
E
A
L
I
-
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
E
F
E
---
S
D
-
E
Y
L
G
E
K
L
------
22
PsiBlast_CBE
93.26
63%
-72
- C1 -
3QN3
5
ENO_CAMJE
C:
[4-417]
M
L
V
I
E
D
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
----------
V
G
A
A
I
V
P
S
G
A
-
S
T
G
S
K
E
A
L
E
L
R
D
N
D
E
-
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
A
D
E
I
L
--
G
--
L
D
A
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
---
G
-----
A
-----
N
-----
A
---
S
I
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
----
L
K
K
E
L
A
N
S
--
G
--
H
S
--
T
A
--
L
G
D
E
G
G
F
A
P
N
L
A
---
N
N
T
----
E
-
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
-
V
K
I
A
L
D
V
A
S
T
E
F
F
-
K
D
---
G
----
K
-
Y
-
H
M
--------
E
-------
G
-----------------
K
A
F
S
S
E
A
L
I
-
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
E
F
E
---
S
D
-
E
Y
L
G
E
K
L
------
23
PsiBlast_CBE
93.15
63%
-73
- C1 -
3QN3
4
ENO_CAMJE
B:
[4-417]
M
L
V
I
E
D
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
----------
V
G
A
A
I
V
P
S
G
A
-
S
T
G
S
K
E
A
L
E
L
R
D
N
D
E
-
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
A
D
E
I
L
--
G
--
L
D
A
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
---
G
-----
A
-----
N
-----
A
---
S
I
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
----
L
K
K
E
L
A
N
S
--
G
--
H
S
--
T
A
--
L
G
D
E
G
G
F
A
P
N
L
A
---
N
N
T
----
E
-
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
-
V
K
I
A
L
D
V
A
S
T
E
F
F
-
K
D
---
G
----
K
-
Y
-
H
M
--------
E
-------
G
-----------------
K
A
F
S
S
E
A
L
I
-
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
E
F
E
---
S
D
-
E
Y
L
G
E
K
L
------
1
PsiBlast_PDB
92.86
63%
-72
- C1 -
3QN3
3
ENO_CAMJE
A:
[4-417]
M
L
V
I
E
D
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
----------
V
G
A
A
I
V
P
S
G
A
-
S
T
G
S
K
E
A
L
E
L
R
D
N
D
E
-
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
A
D
E
I
L
--
G
--
L
D
A
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
---
G
-----
A
-----
N
-----
A
---
S
I
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
----
L
K
K
E
L
A
N
S
--
G
--
H
S
--
T
A
--
L
G
D
E
G
G
F
A
P
N
L
A
---
N
N
T
----
E
-
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
-
V
K
I
A
L
D
V
A
S
T
E
F
F
-
K
D
---
G
----
K
-
Y
-
H
M
--------
E
-------
G
-----------------
K
A
F
S
S
E
A
L
I
-
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
E
F
E
---
S
D
-
E
Y
L
G
E
K
L
------
40
PsiBlast_CBE
92.74
55%
-79
- C1 -
3UJ2
3
?
E:
[26-449]
-
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
-----
L
-----
N
-----
A
---
N
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
---
S
D
E
----
E
-
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
-
G
E
---
K
---
K
G
E
Y
-
I
L
--------
P
-------
K
--------
C
---
K
----
R
K
F
A
S
E
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
-
V
Y
P
G
F
T
T
F
-----
42
PsiBlast_CBE
92.70
55%
-77
- C1 -
3UJ2
5
?
C:
[26-449]
-
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
-----
L
-----
N
-----
A
---
N
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
---
S
D
E
----
E
-
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
-
G
E
---
K
---
K
G
E
Y
-
I
L
--------
P
-------
K
--------
C
---
K
----
R
K
F
A
S
E
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
-
V
Y
P
G
F
T
T
F
-----
25
PsiBlast_CBE
92.25
58%
-78
- C1 -
4Z1Y
1
ENO_CHLAA
B:
[5-425]
---
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
-----
V
-----
Y
-----
A
---
H
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
T
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
---
T
N
D
----
A
-
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
----------------
H
L
--------
K
-------
R
--------
E
---
G
----
R
S
L
S
S
A
E
M
V
-
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
-
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
-
R
Y
A
G
R
S
A
F
K
V
---
38
PsiBlast_CBE
92.22
55%
-77
- C1 -
3UJ2
6
?
G:
[26-449]
-
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
-----
L
-----
N
-----
A
---
N
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
---
S
D
E
----
E
-
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
-
G
E
---
K
---
K
G
E
Y
-
I
L
--------
P
-------
K
--------
C
---
K
----
R
K
F
A
S
E
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
-
V
Y
P
G
F
T
T
F
-----
41
PsiBlast_CBE
92.10
55%
-76
- C1 -
3UJ2
4
?
D:
[26-449]
-
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
-----
L
-----
N
-----
A
---
N
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
---
S
D
E
----
E
-
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
-
G
E
---
K
---
K
G
E
Y
-
I
L
--------
P
-------
K
--------
C
---
K
----
R
K
F
A
S
E
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
-
V
Y
P
G
F
T
T
F
-----
11
PsiBlast_PDB
92.07
55%
-78
- C1 -
3UJ2
5
?
A:
[26-449]
-
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
-----
L
-----
N
-----
A
---
N
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
---
S
D
E
----
E
-
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
-
G
E
---
K
---
K
G
E
Y
-
I
L
--------
P
-------
K
--------
C
---
K
----
R
K
F
A
S
E
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
-
V
Y
P
G
F
T
T
F
-----
43
PsiBlast_CBE
91.94
55%
-75
- C1 -
3UJ2
6
?
B:
[26-449]
-
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
-----
L
-----
N
-----
A
---
N
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
---
S
D
E
----
E
-
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
-
G
E
---
K
---
K
G
E
Y
-
I
L
--------
P
-------
K
--------
C
---
K
----
R
K
F
A
S
E
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
-
V
Y
P
G
F
T
T
F
-----
39
PsiBlast_CBE
91.90
55%
-79
- C1 -
3UJ2
1
?
F:
[26-449]
-
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
-----
L
-----
N
-----
A
---
N
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
---
S
D
E
----
E
-
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
-
G
E
---
K
---
K
G
E
Y
-
I
L
--------
P
-------
K
--------
C
---
K
----
R
K
F
A
S
E
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
-
V
Y
P
G
F
T
T
F
-----
3
PsiBlast_PDB
91.71
58%
-80
- C1 -
4Z17
3
ENO_CHLAA
A:
[5-425]
---
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
-----
V
-----
Y
-----
A
---
H
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
---
T
N
D
----
A
-
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
---
D
---
G
K
-
Y
-
H
L
--------
K
-------
R
--------
E
---
G
----
R
S
L
S
S
A
E
M
V
-
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
-
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
-
R
Y
A
G
R
S
A
F
K
V
---
35
PsiBlast_CBE
91.66
54%
-75
- C1 -
3ZLG
2
ENO_STRP6
B:
[21-438]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
-----
F
-----
N
-----
T
---
K
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
---
G
T
E
----
D
-
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
-
D
K
---
E
RKV
Y
D
-
Y
T
K
F
--------
E
-------
G
--------
E
---
G
A---
A
V
R
T
S
A
E
Q
V
-
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
-
G
E
V
-
A
Q
Y
K
G
I
K
S
F
Y
N
--
33
PsiBlast_CBE
91.54
54%
-76
- C1 -
3ZLG
2
ENO_STRP6
D:
[21-438]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
-----
F
-----
N
-----
T
---
K
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
---
G
T
E
----
D
-
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
-
D
K
---
E
RKV
Y
D
-
Y
T
K
F
--------
E
-------
G
--------
E
---
G
A---
A
V
R
T
S
A
E
Q
V
-
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
-
G
E
V
-
A
Q
Y
K
G
I
K
S
F
Y
N
--
4
PsiBlast_PDB
91.36
58%
-76
- C1 -
4Z1Y
1
ENO_CHLAA
A:
[5-425]
---
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
-----
V
-----
Y
-----
A
---
H
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
T
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
---
T
N
D
----
A
-
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
------
D
---
G
K
-
Y
-
H
L
--------
K
-------
R
--------
E
---
G
----
R
S
L
S
S
A
E
M
V
-
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
-
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
-
R
Y
A
G
R
S
A
F
K
V
---
37
PsiBlast_CBE
91.27
55%
-76
- C1 -
3UJ2
6
?
H:
[26-449]
-
L
E
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
-----
L
-----
N
-----
A
---
N
R
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
----
L
A
G
L
L
K
S
K
--
G
--
L
A
--
T
S
--
V
G
D
E
G
G
F
A
P
D
L
A
---
S
D
E
----
E
-
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
-
F
V
L
A
M
D
A
A
S
S
E
W
K
-
G
E
---
K
---
K
G
E
Y
-
I
L
--------
P
-------
K
--------
C
---
K
----
R
K
F
A
S
E
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
-
V
Y
P
G
F
T
T
F
-----
34
PsiBlast_CBE
91.26
54%
-75
- C1 -
3ZLG
2
ENO_STRP6
C:
[21-438]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
-----
F
-----
N
-----
T
---
K
V
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
G
D
E
G
G
F
A
P
K
F
E
---
G
T
E
----
D
-
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
-
D
K
---
E
RKV
Y
D
-
Y
T
K
F
--------
E
-------
G
--------
E
---
G
A---
A
V
R
T
S
A
E
Q
V
-
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
-
G
E
V
-
A
Q
Y
K
G
I
K
S
F
Y
N
--
112
HHSearch
91.09
53%
-73
- C1 -
2FYM
2
ENO_ECOLI
A:
[1-429]
-
S
K
I
V
K
I
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
H
L
E
G
G
F
----------
V
G
M
A
A
A
P
S
G
A
-
S
T
G
S
R
E
A
L
E
L
R
D
G
D
K
S
R
F
L
G
K
G
V
T
K
A
V
A
A
V
N
G
P
I
A
Q
A
L
I
--
G
--
K
D
A
K
D
Q
A
G
I
D
K
I
M
I
D
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
A
V
S
L
A
N
A
K
A
A
A
A
A
K
G
M
P
L
Y
E
H
---
I
A
---
E
-----
L
-----
N
GTPG-
K
---
Y
S
M
P
V
P
M
M
N
I
I
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
Q
P
V
G
A
K
T
V
K
E
A
I
R
M
G
S
E
V
F
H
H
----
L
A
K
V
L
K
A
K
--
G
--
M
N
--
T
A
--
V
G
D
E
G
G
Y
A
P
N
L
G
---
S
N
A
----
E
-
A
L
A
V
I
A
E
A
V
K
A
A
G
Y
E
L
G
K
D
-
I
T
L
A
M
D
C
A
A
S
E
F
Y
-
K
D
-------
G
K
-
Y
-
V
L
--------
A
-------
G
--------
E
G--
N
----
K
A
F
T
S
E
E
F
T
-
H
F
L
E
E
L
T
K
Q
Y
P
I
V
S
I
E
D
G
L
D
E
S
D
W
D
G
F
A
Y
Q
T
K
V
L
G
D
K
I
Q
L
V
G
D
D
L
-
F
V
T
N
T
K
I
L
K
E
G
I
E
K
G
I
A
N
S
I
L
I
K
F
N
Q
I
G
S
L
T
E
T
L
A
A
I
K
M
A
K
D
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
A
T
I
A
D
L
A
V
G
T
A
A
G
Q
I
K
T
G
S
M
S
R
S
D
R
V
A
K
Y
N
Q
L
I
R
I
E
E
A
L
-
G
E
K
A
P
Y
N
G
R
K
E
I
K
G
Q
--
26
PsiBlast_CBE
90.40
58%
-80
- C1 -
4Z17
3
ENO_CHLAA
B:
[5-425]
---
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
-----
V
-----
Y
-----
A
---
H
V
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
-----
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
G
D
E
G
G
F
A
P
S
L
P
---
T
N
D
----
A
-
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
---
D
---
G
K
-
Y
-
H
L
--------
K
-------
R
--------
E
---
G
----
R
S
L
S
S
A
E
M
V
-
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
-
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
-
R
Y
A
G
R
S
A
F
K
V
---
65
PsiBlast_CBE
86.70
48%
-69
- C1 -
3QTP
6
ENO1_ENTHI
B:
[6-434]
-
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
R
S
C
-
V
P
S
G
A
-
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
G
-----
H
-----
K
-----
E
---
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
YG
Q
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
---
G
A
R
----
E
-
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
--
G
K
-
I
E
I
A
M
D
C
A
A
S
E
F
Y
-
N
E
---
E
---
T
K
K
Y
-
D
L
GKKIPADK
K
-------
D
--------
P
---
S
----
L
V
K
D
V
D
G
L
I
-
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
L
-
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
N
I
-
P
Y
A
G
K
N
W
R
N
S
T
--
66
PsiBlast_CBE
86.12
48%
-68
- C1 -
3QTP
6
ENO1_ENTHI
A:
[6-434]
-
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
R
S
C
-
V
P
S
G
A
-
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
G
-----
H
-----
K
-----
E
---
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
YG
Q
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
---
G
A
R
----
E
-
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
--
G
K
-
I
E
I
A
M
D
C
A
A
S
E
F
Y
-
N
E
---
E
---
T
K
K
Y
-
D
L
GKKIPADK
K
-------
D
--------
P
---
S
----
L
V
K
D
V
D
G
L
I
-
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
L
-
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
N
I
-
P
Y
A
G
K
N
W
R
N
S
T
--
17
PsiBlast_PDB
85.67
47%
-72
- C1 -
3UCC
4
ENOG_HUMAN
A:
[1-416]
--
S
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
18
PsiBlast_PDB
85.46
47%
-71
- C1 -
3UCD
3
ENOG_HUMAN
A:
[1-416]
--
S
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
55
PsiBlast_CBE
85.32
47%
-73
- C1 -
3UJR
3
ENOG_HUMAN
B:
[1-416]
--
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
77
PsiBlast_CBE
85.26
48%
-68
- C1 -
2PU0
7
?
A:
[4-420]
-
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
R
S
A
-
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
-----
T
-----
K
-----
E
---
L
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
YG
Q
--
D
A
--
V
N
--
V
G
D
E
G
G
F
A
P
P
I
K
---
D
I
N
----
E
-
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
-
D
E
KKQ
Q
---
Y
N
-
L
-
T
F
--------
K
-------
S
P-------
E
---
P
----
T
W
V
T
A
E
Q
L
R
-
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
-
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
A
H
-
A
K
F
G
F
P
G
W
S
----
60
PsiBlast_CBE
85.25
47%
-72
- C1 -
3UJE
4
ENOG_HUMAN
A:
[1-416]
--
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
54
PsiBlast_CBE
85.00
47%
-71
- C1 -
3UJS
4
ENOG_HUMAN
A:
[1-416]
--
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
51
PsiBlast_CBE
84.97
47%
-71
- C1 -
3UCD
3
ENOG_HUMAN
B:
[1-416]
--
S
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
116
HHSearch
84.91
46%
-75
- C1 -
3QTP
6
ENO1_ENTHI
A:
[5-437]
S
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
R
S
C
V
P
S
GAS
T
G
V
H
E
A
V
E
L
R
-
D
-----------
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
---
E
-----
L
-----
T
-----
G
HK
E
M
T
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
--
Y
GQ
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
----
D
L
L
V
E
A
I
A
K
A
----
G
Y
--
T
G
K
-
I
E
I
A
M
D
C
A
A
S
E
F
Y
-
N
E
---
E
T--
K
K
-
Y
-
D
L
--------
G
-------
K
KIPADKKD
P
---
S
----
L
V
K
D
V
D
G
L
I
-
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
L
-
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
N
I
-
P
Y
A
G
K
N
W
R
N
S
T
--
56
PsiBlast_CBE
84.90
47%
-73
- C1 -
3UJR
4
ENOG_HUMAN
A:
[1-416]
--
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
76
PsiBlast_CBE
84.81
48%
-68
- C1 -
2PU1
5
?
A:
[4-420]
-
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
R
S
A
-
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
-----
T
-----
K
-----
E
---
L
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
YG
Q
--
D
A
--
V
N
--
V
G
D
E
G
G
F
A
P
P
I
K
---
D
I
N
----
E
-
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
-
D
E
KKQ
Q
---
Y
N
-
L
-
T
F
--------
K
-------
S
P-------
E
---
P
----
T
W
V
T
A
E
Q
L
R
-
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
-
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
A
H
-
A
K
F
G
F
P
G
W
S
----
79
PsiBlast_CBE
84.75
48%
-69
- C1 -
2PTY
4
?
A:
[4-420]
-
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
R
S
A
-
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
-----
T
-----
K
-----
E
---
L
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
YG
Q
--
D
A
--
V
N
--
V
G
D
E
G
G
F
A
P
P
I
K
---
D
I
N
----
E
-
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
-
D
E
KKQ
Q
---
Y
N
-
L
-
T
F
--------
K
-------
S
P-------
E
---
P
----
T
W
V
T
A
E
Q
L
R
-
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
-
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
A
H
-
A
K
F
G
F
P
G
W
S
----
58
PsiBlast_CBE
84.75
47%
-70
- C1 -
3UJF
3
ENOG_HUMAN
A:
[1-416]
--
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
96
PsiBlast_CBE
84.41
45%
-70
- C1 -
2AL1
3
ENO1_YEAST
A:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
-
L
T
T
E
K
G
----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
78
PsiBlast_CBE
84.32
48%
-67
- C1 -
2PTZ
5
?
A:
[4-420]
-
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
R
S
A
-
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
-----
T
-----
K
-----
E
---
L
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
YG
Q
--
D
A
--
V
N
--
V
G
D
E
G
G
F
A
P
P
I
K
---
D
I
N
----
E
-
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
-
D
E
KKQ
Q
---
Y
N
-
L
-
T
F
--------
K
-------
S
P-------
E
---
P
----
T
W
V
T
A
E
Q
L
R
-
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
-
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
A
H
-
A
K
F
G
F
P
G
W
S
----
115
HHSearch
84.18
46%
-72
- C1 -
2AL1
3
ENO1_YEAST
A:
[1-433]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
-----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
-----
L
-----
S
KSKTS
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
A-
S
A
--
G
N
--
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
--
D
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
-
K
D
-------
G
K
-
Y
-
D
L
--------
D
-------
F
KNPNSD--
K
---
S
----
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
--
G
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
A
V
F
A
G
E
N
-
F
H
H
G
--
101
Fugue
84.18
46%
-73
- C1 -
1ONE
3
ENO1_YEAST
A:
[1-436]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
-----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
-----
L
S
KSKT
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
GA
S
A
--
G
N
--
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
-
K
D
-------
G
K
-
Y
-
D
L
DFKNPN--
S
-------
D
--------
K
---
S
----
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
-
V
F
A
G
E
N
F
H
H
G
D
KL
59
PsiBlast_CBE
84.13
47%
-71
- C1 -
3UJE
3
ENOG_HUMAN
B:
[1-416]
--
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
97
PsiBlast_CBE
84.10
45%
-68
- C1 -
1ONE
3
ENO1_YEAST
B:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
-
L
T
T
E
K
G
----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
LSKSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
53
PsiBlast_CBE
84.04
47%
-70
- C1 -
3UJS
3
ENOG_HUMAN
B:
[1-416]
--
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
98
PsiBlast_CBE
83.98
45%
-69
- C1 -
1ONE
3
ENO1_YEAST
A:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
-
L
T
T
E
K
G
----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
93
PsiBlast_CBE
83.77
45%
-70
- C1 -
2ONE
2
ENO1_YEAST
B:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
-
L
T
T
E
K
G
----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
LSKSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
95
PsiBlast_CBE
83.57
45%
-71
- C1 -
2AL1
6
ENO1_YEAST
B:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
-
L
T
T
E
K
G
----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
88
PsiBlast_CBE
83.38
45%
-69
- C1 -
5ENL
2
ENO1_YEAST
A:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
57
PsiBlast_CBE
83.28
47%
-72
- C1 -
3UJF
3
ENOG_HUMAN
B:
[1-416]
--
S
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
52
PsiBlast_CBE
83.28
47%
-71
- C1 -
3UCC
3
ENOG_HUMAN
B:
[1-416]
--
S
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
-----
N
-----
S
-----
D
---
L
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
YG
K
--
D
A
--
T
N
--
V
G
D
E
G
G
F
A
P
N
I
L
---
E
N
S
----
E
-
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
-
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
S
--------
P
TDP
S
----
R
Y
I
T
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
-
G
D
E
-
A
R
F
A
G
H
N
F
R
N
P
--
92
PsiBlast_CBE
83.03
45%
-68
- C1 -
1ELS
3
ENO1_YEAST
A:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
94
PsiBlast_CBE
82.70
45%
-68
- C1 -
2ONE
3
ENO1_YEAST
A:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
-
L
T
T
E
K
G
----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
87
PsiBlast_CBE
81.88
45%
-66
- C1 -
6ENL
2
ENO1_YEAST
A:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
86
PsiBlast_CBE
81.51
45%
-64
- C1 -
7ENL
2
ENO1_YEAST
A:
[2-433]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
R
S
-
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSK
T
-----
S
-----
P
---
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
G
D
E
G
G
V
A
P
N
I
Q
---
T
A
E
----
E
-
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
-
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
---
K
---
Y
D
-
L
-
D
F
--------
K
-------
N
--------
P
---
N
SDKS
K
W
L
T
G
P
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
D
N
-
A
V
F
A
G
E
N
F
H
H
G
--
119
HHSearch
80.20
45%
-71
- C1 -
2PTZ
5
?
A:
[3-429]
H
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
F
R
S
A
V
P
S
G
AS
T
G
V
Y
E
A
C
E
L
R
-
D
-----------
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
---
S
-----
L
-----
A
GTK--
E
---
L
R
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
Y
G
Q
------
D
A
--
V
N
--
V
G
D
E
G
G
F
A
P
P
I
K
---
D
I
N
E
P
L
P
I
-
L
M
E
A
I
E
E
A
----
G
H
--
R
G
K
-
F
A
I
C
M
D
C
A
A
S
E
T
Y
-
D
E
---
K
K--
Q
Q
-
Y
-
N
L
--------
T
-------
F
--------
K
SP
E
P
----
T
W
V
T
A
E
Q
L
R
E
T
Y
C
K
-
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
T
-
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
-
G
A
H
A
K
F
G
F
P
G
W
S
-----
84
PsiBlast_CBE
40.79
46%
14
- C1 -
1PDZ
2
ENO_HOMGA
A:
[4-431]
--
S
I
T
K
V
F
A
R
T
I
F
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
S
K
G
L
----------
F
R
A
A
-
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
Y
H
G
K
S
V
F
N
A
V
K
N
V
N
D
V
I
V
P
E
I
I
K
S
G
--
L
K
V
T
Q
Q
K
E
C
D
E
F
M
C
K
L
D
G
T
E
N
K
S
S
L
G
A
N
A
I
L
G
V
S
L
A
I
C
K
A
G
A
A
E
L
G
I
P
L
Y
R
H
I
A
N
L
A
---
N
-----
Y
-----
D
-----
E
---
V
I
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
T
G
A
T
S
F
T
E
A
M
R
M
G
T
E
V
Y
H
H
----
L
K
A
V
I
K
A
R
--
F
--
G
L
DA
T
A
--
V
G
D
E
G
G
F
A
P
N
I
L
---
N
N
K
----
D
-
A
L
D
L
I
Q
E
A
I
K
K
A
G
Y
T
--
G
K
-
I
E
I
G
M
D
V
A
A
S
E
F
Y
-
K
Q
---
N
---
N
I
-
Y
-
D
L
--------
D
FKTANND
G
--------
S
---
Q
----
K
I
-
S
G
D
Q
L
R
-
D
M
Y
M
E
F
C
K
D
F
P
I
V
S
I
E
D
P
F
D
Q
D
D
W
E
T
W
S
K
M
T
S
--
G
T
T
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
T
T
A
V
E
K
K
A
C
K
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
D
A
H
L
L
A
K
K
N
G
W
G
T
M
V
S
H
R
S
G
E
T
E
D
C
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
I
L
R
I
E
E
E
L
-
G
S
G
-
A
K
F
A
G
K
N
F
R
A
P
--