@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0155: (2015-12-12 )
MNQVELLSPAGNLKKLKIALNYGADAVYGGVSHFSLRNRAGKEFTLETFKEGIDYAHALDKKVYATINGFPFNSQLKLLEEHLYKMAELEPDAFIIAAPGVIKLASKIAPHIPVHLSTQANVLNTLDAQVFYDLGVKRIVCARELSLNDAVEIKKALPDLELEIFVHGSMCFAFSGRCLISALQKGRVPNRGSCANDCRFDYEYYVKNPDNGVMMRLVEEEGVGTHIFNAKDLNLSGHIAEILSSNAISALKIEGRTKSSYYAAQTTRIYRLAVDDFYHNTLKPSFYASELNTLKNRGFTDGYLMRRPFERLDTQNHQTAISEGDFQVNGEITEDGRFFACKFTTTTNTAYEIIAPKNAAITPIVNDIGKIYTFEKRSYLVLYKILLENNTELETIHSGNVNLVRLPAPLPAFSFLRTQVRV
Atome Classification :
(20 SA)
-------------...-......10-.........20.-.......30.--....-..---.40---.........50-------.......-.----60..---......70-----.-------..----..-...80.-......-.90.......--.--------.---------100-------------------.........--110...-----......120---...-.----.....-----130....---------------....140.......150--.......--160...----...-.170.....--...180.......190----..-......-200.......210......-----------.-220....-..-------------.230------..-----.....240.......250---.---......--260.....--..270.......280....-----.-..290..-...---------...300.......310...-....320.......330.......340.--......350.-......360........370..-----.....380-.......390.......-..-400.......410........420----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MN
Q
-
V
E
L
LSPA--GN
L
K
K
L
K
I
A
L
NY-G
A
D
A
V
YGG
V
S
--
H
F
S
L
-RN---RA----GKEF
T
L
E
T
F
K
E-------GI
D
Y
A
H
A
-L----D
K
K
V
---
Y
A
T
INGFP-----F-------
N
S
----
Q
L
-
K
L
L
E
E
H
-
L
Y
K
M
AE-LE-P
D
A
F
I
I
A--A--------
P
---------
G
---------------------
V
I
K
L
A
S
KIA--P--HI
P
-----
V
H
LSTQA-----
N
V
L
-
N
----
T
L
D
A
Q
-----
V
F
-
Y
D
LG---------------V
K
R
I
V
C
ARELSL
N
D
A
V
E
--
I
K
K
ALPD--L
E
L
E
I
F
----
V
HG-
S
M
C
-FAFS
G
--
R
C
L
I
S
A
L
Q
KGRVPNR-----GS-CAND
C
R
-
F
D
Y
E
Y
Y
V
KNPDNG
V
M
M
R
L
V
-----------E-EEGVG
T
H
-
I
F-------------NAKD------LN-----LS
G
H
I
A
E
I
L
SSNA
I
S
A
L
K
---
I
---EGRTKS--
S
Y
Y
A
A
Q
T
T
--
R
I
Y
R
L
A
V
D
D
F
YHNTLKP
S
F
-----
Y
-
A
S
E
L
-
N
T
-
L
KN---------RGFTD
G
Y
L
M
RR
P
F
E
R
LDTQ-NHQTAISEG
D
F
Q
VN
G
E
ITED
G
R
F
F
A
C
K
F
--TTTTN
T
A
Y
E
I
-IAPKNAA
I
-
T
P
I
V
N
D
I
G
K
I
Y
T
F-----EKR
S
Y
L
V
L
-
Y
K
I
L
LENN--T
E
L
E
T
IH-SG-N
V
N
L
V
RLPAPL
P
-
A
F
S
F
L
R
T
QVRV----
34
Fugue
74.08
19%
-50
- C2 -
3WRY
2
?
A:
[8-431]
S
P
R
V
F
C
I
G
TADTK
F
D
E
-
L
R
F
L
S
E
H
V
R
S
S
L
N
S
F
S
N
K
S
S
F
-
K
V
G
V
T
V
V
D
V
S
--
T
S
W
K
-
E
T
---
N
S
----
C
A
D
F
D
F
V
P
-
S
K
-------
D
V
L
S
C
H
T
-
L
----
G
E
E
T
MGT
F
A
D
T
R
G
L
A
-----
I
-------
A
I
----
M
S
-
K
A
L
E
T
F
-
L
S
I
A
N
D
-
E
Q
-
N
L
A
G
V
I
G
L
G
G
--------
S
---------
G
---------------------
G
T
S
L
L
S
S
A
F
--
R
--
S
L
P
IGI
P
K
V
I
I
S
T
V
A
SGQTE
S
Y
I
-
G
----
T
S
D
L
V
-----
L
F
P
S
V
V
D
---------------
I
C
G
I
N
N
V
S
K
V
V
L
S
N
A
G
A
A
F
A
G
M
V
I
G
R
--
L
E
S
K
-
F
----
T
V
G
-
V
T
M
-
F
G
V
T
T
--
P
C
V
N
A
V
--
K
E
R
L
V
K
E
-----
G
-----------
Y
E
T
L
V
F
H
A
-
T
G
V
G
G
R
A
M
-----------
E
-
D
L
V
R
G
G
F
-
I
Q
-------------
G
V
L
D
------
I
T
-----
T
T
----
E
V
A
D
Y
V
V
G
G
V
M
A
---
C
---
D
S
S
R
F
D
--
A
I
L
E
K
K
I
P
--
L
V
L
S
V
G
A
L
D
M
V
N
F
G
P
K
T
T
I
-----
P
-
P
E
F
Q
-
Q
R
-
K
I
H
---------
E
H
N
E
Q
V
S
L
M
R
T
T
---------------------
V
G
E
N
K
K
F
A
A
F
I
A
E
K
L
--
N
K
A
S
S
S
V
C
V
C
-
L
P
E
K
--
G
V
-
S
A
L
D
A
P
G
K
D
F
Y
D
P
-----
E
A
T
S
C
L
T
R
E
L
Q
M
L
L
E
N
N
--
E
R
C
Q
V
K
V
L
P
Y
-
H
I
N
D
A
E
F
A
N
A
L
--
V
D
S
F
L
E
I
S
P
K
-----
39
Fugue
72.16
19%
-47
- C4 -
3ACP
-
RPN14_YEAST
A:
[1-417]
-------------
M
T
K
T
I
T
V
A
H
I
Q
--
Y
D
F
K
A
V
L
E
E
N
D
E
-
N
D
D
E
F
Y
I
N
V
D
--
K
-
N
L
-
N
E
---
I
K
----
E
H
K
I
V
V
L
G
N
S
R
-------
G
V
D
A
G
K
-----------------------------------
G
N
----
T
F
-
E
K
V
G
S
H
-
L
Y
K
-
A
R
-
L
D
-
G
H
D
F
L
F
N
--
T
----------------------------------------
I
I
R
D
G
S
K
M
L
--
K
--
R
A
D
-----
Y
T
A
V
D
T
A
-----
K
-
L
-
Q
----
M
R
R
F
I
-----
L
G
-
T
T
E
G
---------------
D
I
K
V
L
D
S
N
---
F
N
L
Q
R
E
--
I
D
Q
A
H
V
S
EI
T
K
L
K
F
F
----
P
S
G
-
E
A
L
-
I
S
S
S
Q
DM
Q
L
K
I
W
S
V
K
D
G
S
N
P
R
T
L
I
GHR
A
T
-
V
T
D
I
A
I
-
I
D
R
G
R
N
V
L
S
A
S
L
D
G
T
I
R
L
W
-----------
E
C
G
T
G
T
T
I
H
-
T
F
-------------
N
R
K
E
NPHDGV
N
S
-----
I
A
L
F
V
G
T
D
R
Q
L
H
E
I
S
T
S
K
K
N
N
L
---
E
F
G
T
Y
G
--
K
Y
V
I
A
G
H
V
SG
V
I
T
V
H
N
V
F
S
K
E
Q
T
I
Q
L
P
S
K
-----
F
-
T
C
S
C
-
N
S
-
L
T
V
DGNNAN
Y
I
Y
A
G
Y
E
N
G
M
L
A
Q
W
D
L
R
S
P
E
C
P
-
V
G
E
F
L
I
N
E
G
T
P
I
N
N
V
Y
F
A
A
G
A
L
F
V
S
S
G
F
--
D
T
S
I
K
--
L
D
I
-
I
S
D
P
E
S
E
R
-
P
A
I
E
F
E
T
P
T
F
L
V
S
-----
N
D
D
E
V
S
Q
F
-
C
Y
V
S
D
D
E
S
N
G
E
V
L
E
V
G
K
-
N
N
-
F
C
A
L
Y
N
L
S
N
P
------------------
36
Fugue
68.68
14%
-35
* C4 *
4Q9T
-
?
A:
[12-446]
----TKILTETEK
Y
S
V
-
T
K
L
S
T
D
L
--
S
F
L
P
F
E
G
L
V
D
T
A
-
L
Q
K
A
L
V
N
D
L
D
--
H
I
Y
I
-
W
N
---
Y
N
----
S
I
Q
K
D
T
P
I
C
K
I
-------
S
L
H
S
S
P
P
-
I
----
C
L
F
T
----
S
S
I
N
G
I
C
-----
I
I
N
KK---
N
S
----
Q
F
-
L
Y
F
E
D
---------------------------------------------------------------
I
S
T
I
N
N
L
A
--
H
--
V
L
D
-----
L
K
L
K
D
N
E
-----
N
I
T
-
S
----
T
I
N
C
E
PS
G
I
I
I
A
-
T
S
L
G
---------------
R
V
L
F
I
T
I
K
D
S
T
G
K
P
K
L
E
--
L
K
Q
Q
L
I
K
--
P
Q
N
S
F
F
----
F
R
N
-------
L
D
S
--
S
K
E
I
I
S
L
K
K
G
P
I
V
G
K
-----
G
----------
E
R
L
L
Y
I
T
T
R
G
G
S
L
Q
I
W
Q
L
---------------
S
I
N
S
K
-
S
F
-------------
K
R
L
E
------
I
N
-----
I
Y
E
H
V
L
D
S
L
Q
D
L
Y
P
F
A
H
G
-------
T
L
A
F
L
D
--
S
H
P
I
Y
S
D
T
--
S
S
A
H
L
T
L
A
S
I
S
N
G
N
E
I
Y
Y
L
M
----
I
-
T
V
I
L
-
D
E
-
K
--------------
T
N
S
F
Q
I
F
S
I
Y
-
K
L
N
T
Y
-
F
T
K
S
T
V
D
---------
L
N
H
K
P
Q
L
F
I
P
N
A
LD
S
I
V
S
P
T
L
S
V
Y
-
V
L
F
N
N
A
V
V
M
T
Q
I
S
S
K
L
D
S
S
F
P
L
-----
R
R
K
------
W
E
D
I
I
R
F
N
--
K
D
V
E
I
I
G
-
S
G
Y
S
T
D
S
I
Y
V
I
C
K
-
D
M
G
V
L
K
I
A
S
H
-------
28
HHSearch
58.94
17%
-76
- C5 -
1I4N
1
TRPC_THEMA
A:
[112-234]
---------------------------
D
T
V
Q
V
K
L
A
S
S
V
-
G
A
D
A
I
L
I
I
A
R
--
I
L
------------------
T
A
E
Q
I
K
E
-------
I
Y
E
A
A
E
E
-
L
----
G
M
D
S
---
L
V
E
V
H
S
---------------
R
E
----
D
L
-
E
---
K
-----
V
F
S
V
I
R
-
P
K
I
I
G
I
N
--
T
--------
R
---------
D
LDTFEIKKN------------
V
L
W
E
L
L
P
L
V
--
P
D-
D
T
V
-----
V
V
A
E
S
G
-------
I
K
-
D
----
P
R
E
L
K
-----
D
L
-
R
-
G
K
---------------
V
N
A
V
L
V
G
T
S
I
M
K
A
E
N
P
R
--
R
F
L
E
E
M
R
--
A
W
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
58.44
16%
-79
- C5 -
3TSM
1
TRPC_BRUA2
A:
[131-254]
---------------------------
D
P
Y
Q
V
Y
E
A
R
S
W
-
G
A
D
C
I
L
I
I
M
A
--
S
V
D
------------------
D
D
L
A
K
E
-------
L
E
D
T
A
F
A
-
L
----
G
M
D
A
---
L
I
E
V
H
D
---------------
E
A
----
E
M
-
E
--------
R
A
L
K
-
L
S
-
S
R
L
L
G
V
N
--
N
--------
R
NLRSFEVNL
A
---------------------
V
S
E
R
L
A
K
M
A
--
P
S-
D
R
L
-----
L
V
G
E
S
G
-------
I
F
-
T
----
H
E
D
C
L
-----
R
L
-
E
K
S
G
---------------
I
G
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
A
--
A
A
T
R
A
L
L
--
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
58.24
14%
-26
- C2 -
4D10
-
CSN3_HUMAN
C:
[3-403]
-------S
A
L
E
Q
F
V
N
S
-
V
R
Q
L
S
A
Q
--
G
Q
M
T
Q
L
C
E
L
I
N
K
-
S
G
E
L
L
A
K
N
L
S
--
H
L
D
T
-
V
L
---
G
A
---------
L
D
V
Q
E
H
-------
S
L
G
V
L
A
V
-
L
----
F
V
K
--------
F
S
M
P
-----
S
-------
V
P
----
D
F
-
E
T
L
F
S
Q
-
V
Q
L
F
I
S
-
T
C
-
N
G
-----------------------------------------------------------
E
--
H
I
R
-----
Y
A
T
D
T
F
A
-----
G
L
C
-
H
----
Q
L
T
N
A
-----
L
V
-
E
-------------------------
R
K
Q
P
L
R
G
I
G
I
--
L
K
Q
A
I
D
K
--
M
Q
M
N
T
N
QLT
S
I
H
A
-
D
L
C
Q
L
C
L
L
A
--
K
C
F
K
P
A
L
P
Y
L
D
V
D
M
M
-----
D
I
-
C
K
E
N
G
A
-
Y
D
A
K
H
F
L
C
Y
Y
Y
Y
G
G
M
I
Y
T
G
-----------
L
-
K
N
F
E
R
A
L
-
Y
F
-------------
Y
E
Q
A
------
I
T
TPAMA
V
S
H
I
M
L
E
S
Y
K
K
Y
I
L
V
S
L
I
---
L
---
L
G
K
V
Q
Q
L
P
K
Y
T
S
Q
I
V
G
--
R
F
I
K
P
L
S
N
A
Y
H
E
L
A
Q
V
Y
S
T
-----
N
N
P
S
E
L
-
R
N
-
L
V
N
---------
K
H
-------
S
E
T
F
T
R
D
N
N
M
-
G
L
V
K
Q
C
L
S
S
L
Y
K
K
N
I
Q
R
L
T
K
T
F
L
T
L
S
L
Q
--
D
M
A
S
R
V
Q
L
S
G
-
P
Q
E
A
E
K
Y
V
-
L
H
M
I
E
D
G
E
I
F
A
S
I
-----
N
Q
K
D
G
M
V
S
-
F
H
D
N
P
E
K
Y
--
N
N
P
A
M
L
H
-
N
I
-
D
Q
E
M
L
K
C
I
E
L
D
E
-
R
L
K
A
M
D
Q
E
I
T
V
NPQF
21
HHSearch
57.72
14%
-89
- C5 -
1XG4
2
PRPB_ECOLI
A:
[24-200]
-----------------------
T
--
I
N
A
N
H
A
L
L
A
Q
R
A
-
G
Y
Q
A
I
Y
L
S
G
G
--
G
V
A
A
G
S
L
GL-
P
D
----
L
G
I
S
T
L
D
D
V
L
T
-------
D
I
R
R
I
T
D
V
C
----
S
L
P
L
---
L
V
D
A
D
I
G
------
F
-------
G
S
----
S
A
-
F
N
V
A
R
T
-
V
K
S
M
I
K
-
A
G
-
A
A
G
L
H
I
E
--
D
--------
Q
---------
V
GAKRSGHRPN
K
A
I
V
S
K
E
E
M
V
D
R
I
R
A
A
V
D
A
K
TD
P
--
D
F
V
-----
I
M
A
R
T
D
A
-----
L
A
V
E
G
L
D
A
A
I
E
R
A
Q
-----
A
Y
-
V
E
A
G
---------------
A
E
M
L
F
P
E
A
I
T
E
L
A
M
Y
R
Q
--
F
A
D
A
V
Q
V
--
P
I
L
A
N
I
----
T
E
F
-
G
A
T
-
P
L
F
T
T
--
D
E
L
R
S
A
H
V
A
M
A
L
Y
P
L
-----
S
A
-
F
R
A
M
N
R
-
A
A
E
H
V
Y
N
V
L
R
Q
E
G
T
Q
K
S
V
I
-----------
D
-
T
M
Q
T
R
N
E
-
L
Y
-------------
E
S
I
N
------
Y
Y
-----
Q
Y
E
E
K
L
D
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
57.16
15%
-79
- C5 -
3R12
3
DEOC_THEMA
A:
[113-245]
---------------------------
K
A
H
E
A
I
F
A
V
E
S
-
G
A
D
E
I
D
M
V
I
N
--
V
G
M
L
-
K
A
---
K
E
-----
W
E
Y
V
Y
E
D
I
R
S
-------
V
V
E
S
V
K
G
-
K
----
V
V
K
V
---
I
I
E
T
C
Y
L
------
D
-------
T
E
----
E
---
K
I
-
A
A
-
C
V
I
S
K
L
-
A
G
-
A
H
F
V
K
T
S
--
T
--------
G
FGTGGAT
A
-
E
---------------------
D
V
H
L
M
K
W
I
V
--
G
D-
E
M
G
-----
V
K
A
S
G
G
I
-----
R
---
T
----
F
E
D
A
V
-----
K
M
-
I
M
Y
G
---------------
A
D
R
I
G
T
S
S
G
V
K
I
V
Q
G
G
E
--
E
R
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
56.74
13%
-79
- C5 -
1WA3
3
?
A:
[71-184]
--------------------------
T
S
V
E
Q
C
R
K
A
V
E
S
-
G
A
E
F
I
V
S
P
H
L
--
D
------------------------
E
E
-------
I
S
Q
F
C
K
E
-
K
----
G
V
F
Y
---
M
P
G
V
M
T
---------------
P
T
----
E
---------
L
V
K
A
M
K
-
L
G
-
H
T
I
L
K
L
F
--
P
GEVVG---
P
---------
Q
---------------------
F
V
K
A
M
K
G
P
F
--
P
--
N
V
K
-----
F
V
P
T
G
G
V
-----
N
L
--------
D
N
V
C
-----
E
W
-
F
K
A
G
---------------
V
L
A
V
G
V
G
S
A
L
V
K
G
T
P
D
E
--
V
R
E
K
A
K
A
--
F
V
E
K
I
R
----
G
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
56.70
16%
-74
- C5 -
3B8I
4
OADC_PSEAE
A:
[28-201]
-----------------------
V
--
F
D
P
M
S
A
R
I
A
A
D
L
-
G
F
E
C
G
I
L
G
G
S
--
V
A
S
L
-
Q
V
LAA
P
D
----
F
A
L
I
T
L
S
E
F
V
E
-------
Q
A
T
R
I
G
R
-------------
V
A
R
L
P
V
I
A
-----
D
-------
A
D
HGYG
N
A
-
L
N
V
M
R
T
-
V
V
E
L
E
R
-
A
G
-
I
A
A
L
T
I
E
--
D
--------
T
---------
L
LPAQFGRKSTDLIC
V
E
E
G
V
G
-
K
I
R
A
A
L
E
A
R
VD
P
--
A
L
T
-----
I
I
A
R
T
N
A
-----
E
L
I
-
D
V
D
A
V
I
Q
R
T
L
-----
A
Y
-
Q
E
A
G
---------------
A
D
G
I
C
L
V
G
V
R
D
F
A
H
L
E
A
--
I
A
E
H
L
H
I
--
P
L
M
L
V
T
----
Y
G
N
-
P
Q
L
-
R
D
D
A
R
--
L
A
R
L
G
V
R
V
V
V
N
G
H
A
A
-----
Y
F
-
A
A
I
K
A
T
-
Y
D
C
L
R
E
E
R
G
A
V
A
S
D
L
T
A
S
E
-----------
L
-
S
K
K
Y
T
F
P
-
E
E
-------------
Y
Q
A
W
------
A
R
-----
D
Y
M
E
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
56.24
17%
-76
- C5 -
1MZH
-
DEOC_AQUAE
A:
[73-207]
----------------------------
V
K
E
A
V
E
A
V
R
D
-
G
A
Q
E
L
D
I
V
W
N
--
L
S
A
F
-
K
S
---
E
K
-----
Y
D
F
V
V
E
E
L
K
E
-------
I
F
R
E
T
P
S
-
A
----
V
H
K
V
---
I
V
E
T
P
Y
-
L
-----
N
-------
E
E
--------
E
I
K
K
A
-
V
E
I
C
I
E
-
A
G
-
A
D
F
I
K
T
S
--
T
--------
G
---------
F
APRGTT
L
E
-------------
E
V
R
L
I
K
S
S
A
K-
G
--
R
I
K
-----
V
K
A
S
G
G
I
-----
R
---
D
----
L
E
T
A
I
-----
S
M
-
I
E
A
G
---------------
A
D
R
I
G
T
S
S
G
I
S
I
A
E
E
F
L
--
K
R
H
L
I
L
E
--
H
H
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
56.10
13%
-39
- C2 -
3MOI
-
?
A:
[1-387]
-----------------------------
M
K
I
R
F
G
I
C
----
G
L
G
F
A
G
S
V
--
L
M
A
P
-
A
M
---
R
H
----
H
P
D
A
Q
I
V
A
A
C
----------
D
P
N
E
D
-
V
----
R
E
R
F
---
G
K
E
Y
G
I
P
V
-----
F
-------
A
T
----
L
A
-
E
M
M
Q
H
V
---------
Q
-
M
D
A
V
Y
I
A
--
S
--------
P
--------------------------------------
H
Q
--
F
--
H
C
E
-----
H
V
V
Q
A
S
E
-----
Q
----------
G
L
H
-----
I
I
-
V
E
K
P
---------------
L
-------
T
L
S
R
D
E
A
D
R
--
M
I
E
A
V
E
R
--
A
G
V
H
L
V
----
V
G
T
-
S
R
S
-
H
D
P
V
V
--
R
T
L
R
A
I
V
Q
E
G
S
V
G
R
V
-----
S
M
-
L
N
C
F
N
Y
-
T
D
F
L
Y
R
P
R
R
P
E
E
L
D
T
S
K
-------------------
G
G
G
-
I
I
-------------
Y
N
Q
-------
L
P
-----
H
Q
I
D
S
I
K
T
I
T
G
Q
R
I
T
A
V
R
---
A
---
M
T
G
R
L
D
--
P
K
R
P
T
E
G
N
--
C
A
A
M
L
T
L
E
D
G
A
C
A
V
M
V
Y
S
G
YDHFD
S
-
D
E
M
H
-
F
W
-
L
A
E
---------
G
G
R
A
K
Q
P
N
H
G
G
A
R
K
V
L
R
Q
L
-
E
G
D
E
A
E
L
R
R
S
R
Y
G
F
G
G
P
I
S
K
S
D
R
K
Q
P
H
F
--
G
V
M
L
V
T
C
E
H
A
-
D
L
R
A
S
P
E
G
-
V
L
V
Y
G
D
E
G
V
R
E
V
P
A
ITGR
G
P
F
S
Q
G
D
T
-
I
D
E
L
R
D
A
I
--
A
G
V
A
P
A
L
R
D
A
-
R
W
G
K
D
T
L
E
V
C
L
A
-
V
L
E
S
S
A
T
G
R
Q
V
E
R--
38
Fugue
54.81
14%
-2
- C1 -
4OY2
1
TAF1_YEAST
A:
[10-502]
-------------
N
L
N
-
I
Q
H
S
Q
P
A
--
I
N
L
Q
S
P
F
Y
K
V
A
V
P
R
Y
Q
L
R
H
F
H
R
E
--
N
F
G
S
-
H
I
---
R
P
----
G
T
K
I
V
F
S
K
L
K
A
RKRKRDK
G
K
D
V
K
E
S
-
F
----
S
T
S
Q
---
D
L
T
I
-
G
D
T
-----
A
-------
P
V
----
Y
L
M
E
Y
S
E
Q
T
-
P
V
A
L
S
K
-
F
G
M
A
N
K
L
I
N
Y
--
Y
--------
R
---------
K
---------------------
A
N
E
-
Q
D
T
L
R
--
P
--
K
L
P
-----
V
G
---
E
T
-----
H
V
L
-
G
----
V
Q
D
K
S
-----
P
F
-
W
N
F
G
F
V
E
PG
H
I
V
P
T
L
Y
N
NM
I
R
A
P
V
F
K
H
D
I
S
G
T
D
F
L
L
--
T
K
S
S
G
F
G
--
I
S
N
R
F
Y
----
L
R
N
I
N
H
L
-
F
T
V
G
Q
--
T
F
P
V
E
E
I
P
G
P
N
S
R
K
V
-----
T
S
M
K
A
T
R
L
K
M
I
I
Y
R
I
L
N
H
N
H
S
K
A
I
S
I
D
P
I
A
K
H
F
PDQD
Y
G
Q
N
-
R
Q
K
V
K
E
F
M
K
Y
Q
RDGPEKG
L
W
R
L
K
D
D
E
K
------
L
L
-----
D
N
E
A
V
K
S
L
I
T
P
E
Q
I
S
Q
V
E
---
S
M
S
Q
G
L
Q
F
Q
E
--
D
N
E
A
Y
N
F
D
--
S
K
L
K
S
L
E
E
N
L
L
P
W
N
I
T
K
N
F
-----
I
-
N
S
T
Q
M
R
A
M
I
Q
I
---------
H
G
V
G
D
P
T
G
C
G
E
G
F
S
F
L
K
T
S
M
K
H
S
Y
N
V
A
Q
Q
Q
K
A
Y
D
E
E
I
A
K
--
T
W
Y
T
H
T
K
--
S
L
S
I
S
N
P
F
E
E
M
T
N
P
D
E
-------
I
N
Q
T
N
K
-
H
V
K
-----
T
D
R
D
D
K
K
I
-
L
K
I
V
R
K
K
R
--
D
E
N
G
I
I
Q
-
R
Q
-
T
I
F
I
-
R
D
P
R
V
I
Q
-
G
Y
I
K
I
K
E
Q
D
K
E
DVN-
20
HHSearch
53.49
12%
-75
- C5 -
3QJA
1
TRPC_MYCTU
A:
[124-246]
---------------------------
Q
P
Y
Q
I
H
E
A
R
A
H
-
G
A
D
M
L
L
L
I
V
A
--
A
L
------------------
E
Q
S
V
L
V
S
-------
M
L
D
R
T
E
S
-
L
----
G
M
T
A
---
L
V
E
V
H
T
---------------
E
Q
----
E
A
-
D
--------
R
A
L
K
-
A
G
-
A
K
V
I
G
V
N
--
A
--------
R
---------
D
LMTLDVDRD------------
C
F
A
R
I
A
P
G
L
--
P
S-
S
V
I
-----
R
I
A
E
S
G
V
-------
R
-
G
----
T
A
D
L
L
-----
A
Y
-
A
G
A
G
---------------
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
R
--
A
A
V
A
D
L
V
--
T
A
G
T
H
P
----
S
C
P
-
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
52.53
12%
-67
- C5 -
1UB3
1
DEOC_THET8
A:
[73-204]
---------------------------
K
A
L
E
A
A
L
A
C
A
R
-
G
A
D
E
V
D
M
V
L
H
L
G
R
A
K
A
-
G
D
----------
L
D
Y
L
E
A
E
V
R
A
-------
V
R
E
A
V
P
Q
-
A
----
V
L
K
V
---
I
L
E
T
G
Y
F
------
S
-------
P
E
----
E
----
I
A
R
L
-
A
E
A
A
I
R
-
G
G
-
A
D
F
L
K
T
S
--
T
GFGPRGAS
L
---------
E
---------------------
D
V
A
L
L
V
R
V
A
--
Q
G-
R
A
Q
-----
V
K
A
A
G
G
I
-------
R
-
D
----
R
E
T
A
L
-----
R
M
-
L
K
A
G
---------------
A
S
R
L
G
T
S
S
G
V
A
L
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
52.13
15%
-54
- C5 -
2FTP
1
LIUE_PSEAE
A:
[79-181]
-------------------
Y
A
A
L
A
--
P
N
L
K
G
F
E
A
A
L
E
S
-
G
V
K
E
V
A
V
F
A
A
--
A
S
E
A
-
F
S
---
Q
R
N
INC
S
I
K
D
S
L
E
R
F
V
P
-------
V
L
E
A
A
R
Q
-
H
----
Q
V
R
V
---
R
G
Y
I
S
C
V
L
GCPYD
G
-------
D
V
----
D
P
-
R
Q
V
A
W
V
-
A
R
E
L
Q
Q
-
M
G
-
C
Y
E
V
S
L
G
--
D
--------
T
---------
I
---------------------
G
V
G
T
A
G
A
T
R
--
R
--
L
I
E
-----
A
V
A
S
E
V
P
-----
R
E
R
-
L
----
A
G
H
F
H
-----
D
T
-
Y
G
Q
A
---------------
L
A
N
I
Y
A
S
L
L
E
G
I
A
V
F
D
S
--
S
V
A
G
L
G
G
--
C
P
Y
A
K
G
----
A
T
G
-
N
V
A
-
S
E
D
V
L
--
Y
L
L
N
G
L
E
I
H
T
G
V
D
M
H
-----
A
L
-
V
D
A
G
Q
R
-
I
C
A
V
L
G
K
S
N
G
S
R
A
A
K
A
L
L
A
-----------
K
-
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
51.50
14%
-50
- C5 -
1YDO
1
HMGCL_BACSU
A:
[77-179]
-------------------
Y
A
A
L
V
--
P
N
Q
R
G
L
E
N
A
L
E
G
-
G
I
N
E
A
C
V
F
M
S
--
A
S
E
T
-
H
N
---
R
K
N
INK
S
T
S
E
S
L
H
I
L
K
Q
-------
V
N
N
D
A
Q
K
-
A
----
N
L
T
T
---
R
A
Y
L
S
T
V
F
GCPYE
K
-------
D
V
----
P
I
-
E
Q
V
I
R
L
-
S
E
A
L
F
E
-
F
G
-
I
S
E
L
S
L
G
--
D
--------
T
---------
I
---------------------
G
A
A
N
P
A
Q
V
E
--
T
--
V
L
E
-----
A
L
L
A
R
F
P
-----
A
N
Q
-
I
----
A
L
H
F
H
-----
D
T
-
R
G
T
A
---------------
L
A
N
M
V
T
A
L
Q
M
G
I
T
V
F
D
G
--
S
A
G
G
L
G
G
--
C
P
Y
A
P
G
----
S
S
G
-
N
A
A
-
T
E
D
I
V
--
Y
M
L
E
Q
M
D
I
K
T
N
V
K
L
E
-----
K
L
-
L
S
A
A
K
W
-
I
E
E
K
M
G
K
P
L
P
S
R
N
L
Q
V
F
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
51.02
12%
-74
- C5 -
2QIW
7
?
A:
[100-238]
--------------------------------
A
Q
I
L
E
A
-
G
A
V
G
I
N
V
E
D
V
--
V
H
S
E
-
G
K
----------
R
V
R
E
A
Q
E
H
A
D
-------
Y
I
A
A
A
R
Q
-
A
A
D
V
A
G
V
D
V
---
V
I
N
G
R
T
D
A
-----
V
KLGADVF
E
D
----
P
M
-
V
E
A
I
K
R
-
I
K
L
M
E
Q
-
A
G
-
A
R
S
V
Y
P
V
--
G
--------
L
---------
S
---------------------
T
A
E
Q
V
E
R
L
V
--
D
A
V
S
V
P
-----
V
N
I
T
A
H
P
V----
D
G
H
-
G
----
A
G
D
L
A
-----
T
L
-
A
G
L
G
---------------
V
R
R
V
T
F
G
P
L
W
Q
K
W
L
A
A
T
--
S
A
Q
Q
L
K
G
--
W
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
50.33
16%
-99
- C5 -
2WQP
1
?
A:
[87-179]
---------------------------------------------------------------------
A
L
N
E
E
D
E
I
K
-------
L
K
E
Y
V
E
S
-
K
----
G
M
I
F
---
I
S
T
---
L
F
-----
S
-------
R
A
----
A
A
-
L
R
L
Q
R
M
D
I
P
A
----
Y
K
-
I
G
S
G
E
C
N
--
N
--------
Y
---------
P
---------------------
L
I
K
L
V
A
S
F
------
G
K
P
-----
I
I
L
S
T
G
M
-----
N
S
I
-
E
S
I
--
K
K
S
V
E
-----
I
I
-
R
E
A
G
---------------
V
-
P
Y
A
L
L
H
C
T
N
I
Y
P
T
P
Y
--
E
D
V
R
L
G
G
--
M
N
D
L
S
E
----
A
F
P
-
D
A
I
-
I
G
L
S
D
--
H
T
L
D
N
Y
A
C
L
G
A
V
A
L
G
-----
G
S
-
I
L
E
R
H
F
-
T
D
R
M
D
R
P
G
P
D
I
V
C
S
M
N
P
D
T
-----------
F
-
K
E
L
K
Q
G
A
-
H
A
-------------
L
K
L
A
------
R
G
-----
G
K
K
D
T
I
I
A
G
E
K
P
T
K
D
F
A
F
---
A
---
S
V
V
A
D
K
--
D
I
K
K
G
E
L
L
--
S
G
D
N
L
W
V
K
R
P
G
N
G
D
F
S
V
N
E
-----
Y
-
E
T
L
F
-
G
K
-
V
A
A
---------
C
N
I
R
K
G
A
Q
I
K
K
T
D
I
E
-----------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
49.31
20%
-55
- C5 -
3KTS
1
?
A:
[9-100]
---------------
N
-
Q
S
I
I
P
A
A
--
H
N
Q
K
D
M
E
K
I
L
E
L
-
D
L
T
Y
M
V
M
L
E
T
--
H
V
--------------------
A
Q
L
K
A
-------
L
V
K
Y
A
Q
A
-
G
----
G
K
K
V
---
L
L
H
A
D
L
V
N
-----
G
-------
L
K
----
N
D
-
D
Y
A
I
D
F
-
L
C
T
E
---
I
C
-
P
D
G
I
I
S
T
--
R
--------
G
---------
N
---------------------
A
I
M
K
A
K
Q
H
K
--
M
--
L
A
I
-----
Q
R
L
F
M
I
D
-----
S
S
A
-
Y
----
N
K
G
V
A
-----
L
I
-
Q
K
V
Q
---------------
P
D
C
I
E
L
L
P
G
I
I
P
E
Q
V
Q
K
--
M
T
Q
K
L
H
I
--
P
V
I
A
G
G
----
L
I
E
-
T
S
E
-
Q
V
N
Q
V
--
I
A
S
G
A
I
A
V
T
T
S
N
K
H
L
-----
W
E
-
G
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------