@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0157: (2015-12-12 )
MDNYTYSELLKSLQNKCDNIALIIKPEKIKQELERIEKEQEDPNFWQDVLKARDTNKEKVRLNRLLETYQKMKNSLDESVELFELAQNDSDEVTLSLLYEEAPTLEHSVQKVEIEIMLSGENDASNAIITIQPGAGGTESQDWASILYRMYLRWAERKSFKSEILDYQDGEEAGIKGVAFIIKGENAYGYLKNENGVHRLVRISPFDANAKRHTSFASVQISPELDDDIDIEIDEKDVRYDYYRASGAGGQHVNKTESAVRITHFPTGIVVQCQNDRSQHKNKASALKMLKSKLYELELEKQQSSAKNEEKSEIGWGHQIRSYVLAPYQQVKDARSNIAYSNVEAILDGDIDAILEGVLIAKA
Atome Classification :
(20 SA)
----------------.........10....-....20........30........40........50........60........70.....--...80........90-------------........100........110.----.----.----------....120..-.....130.......--140.......150.......160.......170.......180.......190.......200...-------...-.210........220..----.....-----230...--.....240.....-..250.......-260------.---------------------.------..-----------------.---.-------------------------.270.......280.......290.......300--..--....--.310.---------...-.---.-.---320-.......--..330.-.....-.--------340.......350.......360.-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------MDNY
T
Y
S
E
L
L
K
S
L
Q
N-KCD
N
I
A
L
I
IK
P
E
K
I
K
Q
E
L
E
R
I
E
K
EQED
P
N
F
W
Q
D
V
L
K
ARDT
N
K
E
K
V
R
L
N
R
L
L
E
T
Y
Q
K
M
K
N
S
L
--
D
E
S
V
E
L
F
E
L
AQNDSD-------------
E
V
T
L
S
L
L
YE-EAPTLEHS
V
Q
K
V
E
----
I
----
E
----------
I
M
L
SGENDA-S
N
A
I
I
T
I
QPGAGGTE--
S
Q
D
W
A
S
I
L
Y
R
M
Y
L
R
W
A
E
R
K
S
F
K
S
E
ILDYQDGEEAGIK
G
V
A
F
I
I
KGEN
A
Y
G
Y
LKNENG
V
H
R
L
V
R
ISP-------FDA-NAK-RH
T
S
F
A
S
V
Q
ISPE----LDDDI-----
D
-
I
E
ID--EKD
V
R
Y
D
Y
Y
RASG-AGGQHVNKTE
S
A
-
V
R
I
------T---------------------H------FP-----------------T---
G
-------------------------
I
V
V
Q
CQN
D
R
S
QHK
N
K
A
S
A
L
K
M
L
K
S
K
L
Y
E
L
E
L
E
K
Q
--QS--SAKN--E
E
K
SE---------IG
W
-
G
---
H
-
Q
---
I
---
R
S
Y
V
L
A
P
--
Y
Q
Q
V
K
D
-
A
R
SNI-
A
--------
Y
S
N
V
E
A
I
LDG
D
I
D
A
I
L
E
G
V
LIAKA-----
5
PsiBlast_PDB
79.55
41%
-57
- C4 -
1RQ0
-
RF1_THEMA
A:
[32-317]
----------------------------------------------------------------------------------
I
E
E
I
E
N
I
T
N
R
I
--
K
E
T
Q
E
F
I
E
L
L
R
E
E
G
E
-------------
N
E
L
E
I
E
K
Y
E
-
K
E
--
L
D
Q
L
Y
Q
--
E
----
L
----
L
----------
F
L
L
S
P
E
A
-
S
-
D
K
A
I
V
E
I
R
P
G
T
G
G
E
E
--
A
A
L
F
A
R
D
L
F
R
M
Y
T
R
Y
A
E
R
K
G
W
N
L
E
V
A
E
I
H
E
T
D
L
G
G
I
R
E
V
V
F
F
V
K
G
K
N
A
Y
G
I
L
K
Y
E
S
G
V
H
R
V
Q
R
V
P
V
-------
T
E
S
-
G
G
R
-
I
H
T
S
T
A
T
V
A
V
L
P
E
----
I
E
E
K
------
D
-
I
E
I
R
--
P
E
D
L
K
I
E
T
F
R
A
S
G
-----
Y
V
N
K
T
E
S
A
-
V
R
I
------
T
---------------------
H
------
L
P
-----------------
T
---
G
-------------------------
I
V
V
S
C
Q
N
E
R
S
Q
Y
Q
N
K
Q
T
A
L
R
I
L
R
A
R
L
Y
Q
L
Q
K
E
Q
K
--
E
R
--
E
I
S
Q
--------------------------
R
SEK
I
---
R
T
Y
N
F
-
P
--
Q
N
R
V
T
D
-
H
R
I
N
Y
-
T
--------
S
Y
R
L
Q
E
I
L
D
G
D
L
D
E
I
I
S
K
L
I
E
H
D
I
-----
17
HHSearch
77.85
37%
-42
- C4 -
1RQ0
-
RF1_THEMA
A:
[1-324]
---------------------------------------------
M
K
E
K
K
K
E
I
E
K
L
L
A
R
P
D
L
T
P
E
--
Q
M
K
N
Y
G
M
E
Y
A
K
I
E
E
I
E
N
I
T
N
R
I
K
E
T
------
Q
E
F
I
E
L
L
R
E
E
-------------------
G
E
N
E
L
-
E
I
E
K
Y
E
K
E
L
D
Q
L
Y
----
Q
E
---
L
----------
L
F
L
L
S
P
E
A
S
-
D
K
A
I
V
E
I
R
P
G
T
G
G
E
E
--
A
A
L
F
A
R
D
L
F
R
M
Y
T
R
Y
A
E
R
K
G
W
N
L
E
V
A
E
I
H
E
T
D
L
G
G
I
R
E
V
V
F
F
V
K
G
K
N
A
Y
G
I
L
K
Y
E
S
G
V
H
R
V
Q
R
V
P
V
-------
T
E
S
-
G
G
R
-
I
H
T
S
T
A
T
V
A
V
L
P
E
----
I
E
E
-
K
-----
D
-
I
E
I
R
--
P
E
D
L
K
I
E
T
F
R
A
S
G
-----
Y
V
N
K
T
E
S
A
-
V
R
I
------
T
---------------------
H
------
L
P
-----------------
T
---
G
-------------------------
I
V
V
S
C
Q
N
E
R
S
Q
Y
Q
N
K
Q
T
A
L
R
I
L
R
A
R
L
Y
Q
L
Q
K
E
Q
K
--
E
R
--
E
I
S
Q
-------------------R
S
---
E
-
K
---
I
---
R
T
Y
N
F
P
Q
---
N
R
V
T
D
-
H
R
I
N
Y
-
T
--------
S
Y
R
L
Q
E
I
L
D
G
D
L
D
E
I
I
S
K
L
I
E
H
D
I
-----
6
PsiBlast_PDB
76.76
39%
-62
- C4 -
2B3T
-
RF1_ECOLI
B:
[106-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
E
-
R
N
A
F
L
E
V
R
A
G
T
G
G
D
E
--
A
A
L
F
A
G
D
L
F
R
M
Y
S
R
Y
A
E
A
R
R
W
R
V
E
I
M
S
A
S
E
G
E
H
G
G
Y
K
E
I
I
A
K
I
S
G
D
G
V
Y
G
R
L
K
F
E
S
G
G
H
R
V
Q
R
V
P
A
-------
T
E
S
-
Q
G
R
-
I
H
T
S
A
C
T
V
A
V
M
P
E
----
L
P
D
A
E
-----
L
-
P
D
V
N
--
P
A
D
L
R
I
D
T
F
R
S
S
G
-
A
G
G
Q
H
V
N
T
T
D
S
A
-
I
R
I
------
T
---------------------
H
------
L
P
-----------------
T
---
G
-------------------------
I
V
V
E
C
Q
D
E
R
S
Q
H
K
N
K
A
K
A
L
S
V
L
G
A
R
I
H
A
A
E
M
A
K
R
--
Q
----------
R
R
N
------------------------
S
DRN
R
T
Y
N
F
-
P
--
Q
G
R
V
T
D
-
H
R
I
N
L
-
T
--------
L
Y
R
L
D
E
V
M
E
G
K
L
D
M
L
I
E
P
I
I
Q
E
H
Q
-----
13
HHSearch
76.39
48%
26
- C4 -
1GQE
-
RF2_ECOLI
A:
[4-364]
------------------
I
N
P
V
N
N
R
I
Q
D
L
T
E
-
R
S
D
V
L
R
G
Y
L
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
V
W
N
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
L
D
Q
M
K
Q
G
L
--
E
D
V
S
G
L
L
E
L
A
V
E
A
D
D
-------------
E
E
T
F
N
E
A
V
A
-
E
L
D
A
L
E
E
K
L
A
Q
L
E
----
F
----
R
----------
R
M
F
S
G
E
Y
D
S
-
A
D
C
Y
L
D
I
Q
A
G
S
G
G
T
E
--
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
A
E
S
R
G
F
K
T
E
I
I
E
E
S
E
G
E
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
E
T
G
V
H
R
L
V
R
K
S
P
-------
F
D
S
-
G
G
R
-
R
H
T
S
F
S
S
A
F
V
Y
P
E
----
V
D
D
D
I
-----
D
-
I
E
I
N
--
P
A
D
L
R
I
D
V
Y
R
A
S
G
-
A
G
G
Q
H
V
N
R
T
E
S
A
-
V
R
I
------
T
---------------------
H
------
I
P
-----------------
T
---
G
-------------------------
I
V
T
Q
C
Q
N
D
R
S
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
Y
E
V
E
M
Q
K
K
--
N
A
--
E
K
Q
A
ME
D
N
K
S
D
---------
I
G
W
-
G
---
S
-
Q
---
I
---
R
S
Y
V
L
D
D
---
S
R
I
K
D
-
L
R
T
G
V
-
E
--------
T
R
N
T
Q
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
-----
16
HHSearch
74.95
31%
-47
- C4 -
2B3T
-
RF1_ECOLI
B:
[7-348]
----------------------------------------
A
K
L
E
A
L
H
E
R
H
E
E
V
Q
A
L
L
G
D
A
Q
T
I
A
D
Q
E
R
F
R
A
L
S
R
E
Y
A
Q
L
S
D
V
S
R
C
F
T
D
W
Q
Q
V
----------------------------------------------------------
Q
QLQV
L
----------
L
L
P
K
D
P
D
D
E
-
R
N
A
F
L
E
V
R
A
G
T
G
G
D
E
--
A
A
L
F
A
G
D
L
F
R
M
Y
S
R
Y
A
E
A
R
R
W
R
V
E
I
M
S
A
S
E
G
E
H
G
G
Y
K
E
I
I
A
K
I
S
G
D
G
V
Y
G
R
L
K
F
E
S
G
G
H
R
V
Q
R
V
P
A
-------
T
E
S
-
Q
G
R
-
I
H
T
S
A
C
T
V
A
V
M
P
E
----
L
P
D
A
E
-----
L
-
P
D
V
N
--
P
A
D
L
R
I
D
T
F
R
S
S
G
-
A
G
G
Q
H
V
N
T
T
D
S
A
-
I
R
I
------
T
---------------------
H
------
L
P
-----------------
T
---
G
-------------------------
I
V
V
E
C
Q
D
E
R
S
Q
H
K
N
K
A
K
A
L
S
V
L
G
A
R
I
H
A
A
E
M
A
K
R
--
Q
-------R-
R
N
----------------
S
---
D
-
R
---
N
---
R
T
Y
N
F
P
Q
---
G
R
V
T
D
-
H
R
I
N
L
-
T
--------
L
Y
R
L
D
E
V
M
E
G
K
L
D
M
L
I
E
P
I
I
Q
E
H
Q
-----
3
PsiBlast_PDB
74.35
48%
31
- C4 -
1GQE
-
RF2_ECOLI
A:
[11-363]
-------------------------
I
Q
D
L
T
E
-
R
S
D
V
L
R
G
Y
L
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
V
W
N
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
L
D
Q
M
K
Q
G
L
--
E
D
V
S
G
L
L
E
L
A
V
E
A
D
D
-------------
E
E
T
F
N
E
A
V
A
-
E
L
D
A
L
E
E
K
L
A
Q
L
E
----
F
----
R
----------
R
M
F
S
G
E
Y
D
S
-
A
D
C
Y
L
D
I
Q
A
G
S
G
G
T
E
--
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
A
E
S
R
G
F
K
T
E
I
I
E
E
S
E
G
E
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
E
T
G
V
H
R
L
V
R
K
S
P
-------
F
D
S
-
G
G
R
-
R
H
T
S
F
S
S
A
F
V
Y
P
E
----
V
D
D
D
I
-----
D
-
I
E
I
N
--
P
A
D
L
R
I
D
V
Y
R
A
S
G
-
A
G
G
Q
H
V
N
R
T
E
S
A
-
V
R
I
------
T
---------------------
H
------
I
P
-----------------
T
---
G
-------------------------
I
V
T
Q
C
Q
N
D
R
S
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
Y
E
V
E
M
Q
K
K
N
A
E
K
--
Q
A
M
E
--
D
N
K
S
D
---------
I
G
W
-
G
---
S
-
Q
---
I
---
R
S
Y
V
L
D
D
---
S
R
I
K
D
-
L
R
T
G
V
-
E
--------
T
R
N
T
Q
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
-----
2
PsiBlast_PDB
67.36
49%
182
- C- -
1ML5
1
RF2_ECOLI
Z:
[11-363]
-------------------------
I
Q
D
L
T
E
-
R
S
D
V
L
R
G
Y
L
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
V
W
N
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
L
D
Q
M
K
Q
G
L
--
E
D
V
S
G
L
L
E
L
A
V
E
A
D
D
-------------
E
E
T
F
N
E
A
V
A
-
E
L
D
A
L
E
E
K
L
A
Q
L
E
----
F
----
R
----------
R
M
F
S
G
E
Y
D
S
-
A
D
C
Y
L
D
I
Q
A
G
S
G
G
T
E
--
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
A
E
S
R
G
F
K
T
E
I
I
E
E
S
E
G
E
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
E
T
G
V
H
R
L
V
R
K
S
P
-------
F
D
S
-
G
G
R
-
R
H
T
S
F
S
S
A
F
V
Y
P
E
----
V
D
D
D
I
-----
D
-
I
E
I
N
--
P
A
D
L
R
I
D
V
Y
R
T
S
G
-
A
G
G
Q
H
V
N
R
T
E
S
A
-
V
R
I
------
T
---------------------
H
------
I
P
-----------------
T
---
G
-------------------------
I
V
T
Q
C
Q
N
D
R
S
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
Y
E
L
E
M
Q
K
K
NA
E
K
--
Q
A
M
E
--
D
N
K
S
D
---------
I
G
W
-
G
---
S
-
Q
---
I
---
R
S
Y
V
L
D
D
---
S
R
I
K
D
-
L
R
T
G
V
-
E
--------
T
R
N
T
Q
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
-----
1
PsiBlast_PDB
66.98
49%
182
- C- -
1MI6
-
RF2_ECOLI
A:
[11-363]
-------------------------
I
Q
D
L
T
E
-
R
S
D
V
L
R
G
Y
L
D
Y
D
A
K
K
E
R
L
E
E
V
N
A
E
L
E
Q
P
D
V
W
N
E
P
E
R
A
Q
A
L
G
K
E
R
S
S
L
E
A
V
V
D
T
L
D
Q
M
K
Q
G
L
--
E
D
V
S
G
L
L
E
L
A
V
E
A
D
D
-------------
E
E
T
F
N
E
A
V
A
-
E
L
D
A
L
E
E
K
L
A
Q
L
E
----
F
----
R
----------
R
M
F
S
G
E
Y
D
S
-
A
D
C
Y
L
D
I
Q
A
G
S
G
G
T
E
--
A
Q
D
W
A
S
M
L
E
R
M
Y
L
R
W
A
E
S
R
G
F
K
T
E
I
I
E
E
S
E
G
E
V
A
G
I
K
S
V
T
I
K
I
S
G
D
Y
A
Y
G
W
L
R
T
E
T
G
V
H
R
L
V
R
K
S
P
-------
F
D
S
-
G
G
R
-
R
H
T
S
F
S
S
A
F
V
Y
P
E
----
V
D
D
D
I
-----
D
-
I
E
I
N
--
P
A
D
L
R
I
D
V
Y
R
A
S
G
-
A
G
G
Q
H
V
N
R
T
E
S
A
-
V
R
I
------
T
---------------------
H
------
I
P
-----------------
T
---
G
-------------------------
I
V
T
Q
C
Q
N
D
R
S
Q
H
K
N
K
D
Q
A
M
K
Q
M
K
A
K
L
Y
E
V
E
M
Q
K
K
--
N
A
E
K
Q
A
M
E
--
D
N
K
S
D
---------
I
G
W
-
G
---
S
-
Q
---
I
---
R
S
Y
V
L
D
D
---
S
R
I
K
D
-
L
R
T
G
V
-
E
--------
T
R
N
T
Q
A
V
L
D
G
S
L
D
Q
F
I
E
A
S
L
K
A
G
L
-----
7
PsiBlast_PDB
54.42
34%
27
- C4 -
1ZBT
-
RF1_STRMU
A:
[96-347]
----------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
----
F
----
L
----------
L
L
P
K
D
P
N
D
D
-
K
N
I
I
L
E
I
R
G
A
A
G
G
D
E
--
A
A
L
F
A
G
D
L
L
N
M
Y
Q
K
Y
A
E
N
Q
G
W
K
F
E
V
M
E
A
S
A
N
G
V
G
G
L
K
E
V
V
A
M
V
S
G
Q
S
V
Y
S
K
L
K
Y
E
S
G
A
H
R
V
Q
R
V
P
V
-------
T
E
S
-
Q
G
R
-
V
H
T
S
T
A
T
V
L
V
M
P
E
----
V
E
E
V
E
-------
Y
E
I
D
--
P
K
D
L
R
V
D
I
Y
H
A
----------
K
V
A
T
A
-
V
R
I
------
I
---------------------
H
------
L
P
-----------------
T
---
N
-------------------------
I
K
V
E
M
Q
E
E
R
T
Q
Q
K
N
R
D
K
A
M
K
I
I
R
A
R
V
A
D
H
F
A
Q
I
A
--
Q
D
--
E
Q
D
A
------
T
---------
V
G
T
-
G
DRS
E
-
R
---
I
---
R
T
Y
N
F
-
P
--
Q
N
R
V
T
D
-
H
R
I
G
L
-
T
--------
L
Q
K
L
D
S
I
L
S
G
K
L
D
E
V
I
D
A
L
I
L
Y
D
Q
-----
4
PsiBlast_PDB
51.56
41%
146
- C- -
2FVO
-
RF1_THEMA
A:
[32-321]
----------------------------------------------------------------------------------
I
E
E
I
E
N
I
T
N
R
I
--
K
E
T
Q
E
F
I
E
L
L
R
E
E
G
E
-------------
N
E
L
E
I
E
K
Y
E
-
K
E
--
L
D
Q
L
Y
Q
--
E
----
L
----
L
----------
F
L
L
S
P
E
A
-
S
-
D
K
A
I
V
E
I
R
P
G
T
G
G
E
E
--
A
A
L
F
A
R
D
L
F
R
M
Y
T
R
Y
A
E
R
K
G
W
N
L
E
V
A
E
I
H
E
T
D
L
G
G
I
R
E
V
V
F
F
V
K
G
K
N
A
Y
G
I
L
K
Y
E
S
G
V
H
R
V
Q
R
V
P
V
-------
T
E
S
-
G
G
R
-
I
H
T
S
T
A
T
V
A
V
L
P
E
----
I
E
E
K
------
D
-
I
E
I
R
--
P
E
D
L
K
I
E
T
F
R
A
S
G
----------
E
S
A
-
V
R
I
------
T
---------------------
H
------
L
P
-----------------
T
---
G
-------------------------
I
V
V
S
C
Q
N
E
R
S
Q
Y
Q
N
K
Q
T
A
L
R
I
L
R
A
R
L
Y
Q
L
Q
K
E
Q
K
--
E
R
--
E
I
S
Q
--------------------------
R
SEK
I
---
R
T
Y
N
F
-
P
--
Q
N
R
V
T
D
-
H
R
I
N
Y
-
T
--------
S
Y
R
L
Q
E
I
L
D
G
D
L
D
E
I
I
S
K
L
I
E
H
D
I
-----
19
HHSearch
51.38
33%
-35
- C4 -
2JVA
-
?
A:
[6-101]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----
N
-
V
H
L
P
--
D
A
E
I
E
L
T
A
I
R
A
Q
G
-
A
G
G
Q
N
V
N
K
V
S
S
A
-
M
H
L
------
R
---------------------
F
DINASS
L
P
P
F
Y
K
E
R
L
L
A
LNDSRITS
D
---
G
V
------------------------
I
V
L
K
A
Q
Q
Y
R
T
Q
E
Q
N
R
A
D
A
L
L
R
L
S
E
L
I
V
N
A
A
K
L
E
H
--
H
H
--
H
H
H
-----------------------------------------------------------------------------------------------
15
HHSearch
47.20
27%
58
- C4 -
1ZBT
-
RF1_STRMU
A:
[-1-349]
-----------------------------------
H
M
N
I
Y
D
Q
L
Q
A
V
E
D
R
Y
E
E
L
--------------------
R
E
E
A
N
S
R
E
T
V
A
V
Y
R
E
Y
K
Q
V
V
--
Q
N
I
A
D
A
Q
E
M
-------------------
P
E
L
E
E
M
A
K
E
-
E
L
K
N
S
K
V
A
K
E
E
Y
E
E
K
L
R
F
----
L
----------
L
L
P
K
D
P
N
D
D
-
K
N
I
I
L
E
I
R
G
A
A
G
G
D
E
--
A
A
L
F
A
G
D
L
L
N
M
Y
Q
K
Y
A
E
N
Q
G
W
K
F
E
V
M
E
A
S
A
N
G
V
G
G
L
K
E
V
V
A
M
V
S
G
Q
S
V
Y
S
K
L
K
Y
E
S
G
A
H
R
V
Q
R
V
P
V
-------
T
E
S
-
Q
G
R
-
V
H
T
S
T
A
T
V
L
V
M
P
E
----
V
E
E
-
V
-----
E
-
Y
E
I
D
--
P
K
D
L
R
V
D
I
Y
H
A
----------
K
V
A
T
A
-
V
R
I
------
I
---------------------
H
------
L
P
-----------------
T
---
N
-------------------------
I
K
V
E
M
Q
E
E
R
T
Q
Q
K
N
R
D
K
A
M
K
I
I
R
A
R
V
A
D
H
F
A
Q
I
A
--
Q
D
--
E
Q
D
A
----
T
V
G
---------
T
G
D
R
S
---
E
-
R
---
I
---
R
T
Y
N
F
P
Q
---
N
R
V
T
D
-
H
R
I
G
L
-
T
--------
L
Q
K
L
D
S
I
L
S
G
K
L
D
E
V
I
D
A
L
I
L
Y
D
Q
-----
27
Fugue
46.62
21%
0
* C2 *
4R6Y
2
PHNS_SALTY
A:
[1-317]
SME
S
V
V
T
V
Y
S
I
D
GLHD
G
D
N
S
W
Y
Q
V
Q
F
D
A
F
T
K
-
A
T
-
G
I
T
V
R
Y
V
E
G
G
G
G
V
V
V
E
R
L
A
K
E
R
T
N
P
Q
A
--
D
V
L
V
T
A
P
P
F
I
Q
R
A
A
A
E
K
L
L
A
N
F
N
T
D
T
A
S
A
IP
D
A
N
N
L
Y
S
P
L
V
K
N
Y
------------------
L
S
F
I
Y
N
-
S
K
L
L
K
---------------------------------------------------
T
A
--
P
A
S
W
Q
D
L
L
---------
D
G
K
F
K
N
K
-
L
Q
Y
S
T
P
G
Q
A
-
A
D
G
T
A
V
M
L
Q
A
F
H
S
F
G
--
S
K
D
A
G
F
A
Y
L
G
K
L
Q
A
-------
N
N
V
-
G
P
S
-
A
S
T
G
K
L
T
A
L
V
N
K
G
EIY
V
A
N
G
D
L
-----
Q
-
M
N
L
A
Q
M
E
R
N
P
N
V
K
I
F
W
P
A
N
-
D
K
G
E
R
-----
S
A
-
L
A
I
------
P
-----------------------------------------------------------------------------
Y
V
I
G
L
V
Q
G
A
P
Q
S
E
N
G
K
K
L
I
N
F
L
L
S
K
E
A
Q
------------------
T
R
V
S
E
---------
L
S
W
-
G
---
M
-
P
---
V
---
R
S
D
V
T
P
S
--
D
E
H
Y
K
A
-
A
T
A
A
L
-
E
G
V
Q
S
W
Q
P
N
W
D
D
V
A
V
S
L
S
A
D
I
S
R
W
H
K
V
T
E
S
--------
22
HHSearch
45.36
37%
-48
- C4 -
2JY9
-
?
A:
[6-102]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
T
-
V
S
I
A
--
D
N
E
L
E
I
T
A
I
R
A
Q
G
-
A
G
G
Q
H
V
N
K
T
S
S
A
-
I
H
L
------
R
F
D
IRA
S
G
L
P
E
Y
Y
K
Q
R
L
L
T
ASH
H
------
L
I
-----------------
S
DDG
V
-------------------------
I
I
I
K
A
Q
E
F
R
S
Q
E
L
N
R
E
A
A
I
A
R
L
V
A
V
I
K
E
L
T
A
E
Q
K
--
S
R
--
R
A
T
R
--
P
T
R
A
S
---------
K
E
R
-
R
---
L
-
S
---
S
---
K
A
Q
K
S
S
V
--
K
A
L
R
G
K
-
V
R
R
P
L
-
D
--------
L
E
H
H
H
H
H
H
---------------------
10
PsiBlast_PDB
44.72
27%
-27
- C4 -
2JVA
-
?
A:
[7-91]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
V
H
L
P
--
D
A
E
I
E
L
T
A
I
R
A
Q
G
-
A
G
G
Q
N
V
N
K
V
S
S
A
-
M
H
L
R
F
DINA
S
---------------------
S
------
L
P
-----------------
P
---
F
Y
K
E
R
L
L
A
LNDSRITSDG
V
-------
I
V
L
K
A
Q
Q
Y
R
T
Q
E
Q
N
R
A
D
A
L
L
R
L
S
E
L
I
V
N
A
A
K
L
E
H
--
H
H
--
H
H
H
-----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
44.33
33%
-51
- C4 -
2RSM
-
CL065_MOUSE
A:
[27-104]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
V
Q
V
A
G
R
----
K
D
Y
P
A
-----
L
-
L
P
L
N
--
E
S
E
L
E
E
Q
F
V
K
G
H
G
-
P
G
G
Q
A
T
N
K
T
S
N
C
-
V
V
L
------
K
---------------------
H
------
V
P
-----------------
S
---
G
-------------------------
I
V
V
K
C
H
Q
T
R
S
V
D
Q
N
R
K
I
A
R
K
V
L
Q
E
K
V
D
V
F
Y
N
S
G
P
--
S
S
--
G
-------------------------------------------------------------------------------------------------
26
Fugue
42.72
25%
-0
- C4 -
1J26
-
ICT1_MOUSE
A:
[1-112]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
S
S
G
E
----
H
A
K
Q
A
-----
S
-
S
Y
I
P
--
L
D
R
L
S
I
S
Y
C
R
S
S
G
-
P
G
G
Q
N
V
N
K
V
N
S
K
-
A
E
V
------
R
---------------------
F
------
H
L
-----------------
A
---
S
ADWIE
E
P
V
R
Q
K
I
A
L
T
HKNKINKAG
E
L
V
L
T
S
E
S
S
R
Y
Q
F
R
N
L
A
E
C
L
Q
K
I
R
D
M
I
A
E
A
S
G
P
S
S
--
G
-----------------------------------------------------------------------------------------------------
29
Fugue
41.91
11%
-17
* C3 *
3D68
6
CBPB2_HUMAN
A:
[24-424]
----------------
A
Q
S
G
Q
V
L
A
A
L
P
R
T
S
R
-
Q
V
Q
V
L
Q
N
L
T
T
T
Y
E
I
V
L
W
Q
P
V
T
A
D
L
I
V
K
K
K
Q
V
H
F
F
V
N
A
S
D
V
D
N
V
K
A
H
L
N
V
S
G
I
P
C
S
V
L
L
A
D
V
--
E
D
L
I
Q
Q
Q
I
S
N
D
T
V
S
P
RAS
A
S
Y
Y
E
Q
YHS
L
N
E
I
Y
S
W
I
E
F
-
I
T
E
R
H
P
D
M
L
T
K
I
H
----
I
----
G
SSFEKY
P
L
Y
V
L
K
V
S
G
K
E
Q
T
-
A
K
N
A
I
W
I
D
C
G
I
H
A
R
E
W
I
S
P
A
F
C
L
W
F
I
G
H
I
T
Q
F
Y
G
I
I
G
Q
Y
T
N
L
L
R
L
-------
V
D
F
Y
V
M
P
V
V
N
V
D
G
Y
D
Y
S
W
K
K
N
R
M
W
R
K
N
R
S
F
Y
ANNH
C
I
G
T
D
L
-
N
R
N
F
A
S
K
H
W
C
E
E
G
A
S
S
S
----
S
C
S
E
T
YCGLY
P
-
E
S
E
P
--
E
V
K
A
V
A
S
F
L
R
R
N
I
-------
N
Q
I
K
A
Y
-
I
S
M
------
H
---------------------
S
------
Y
S
-----------------
Q
---
H
-------------------------
I
V
F
P
Y
S
Y
T
R
S
K
S
K
D
H
E
E
L
S
L
V
A
S
E
A
V
R
A
I
E
K
I
S
K
--
N
I
--
R
Y
T
Y
--
G
Q
G
S
E
TLYLAPGG
G
D
D
W
-
I
---
Y
-
D
---
L
---
G
I
K
Y
S
F
T
--
I
E
L
R
D
T
-
G
T
Y
G
F
-
L
LP------
E
R
Y
I
K
P
T
C
R
E
A
F
A
A
V
S
K
I
A
W
H
V
I
R
NV---
33
Fugue
41.72
16%
3
- C1 -
4DVG
-
?
B:
[8-312]
------------------
E
V
V
Q
Q
K
F
A
I
V
A
K
E
M
K
I
D
N
P
E
L
I
-----------------
T
I
P
N
Q
W
K
L
V
Q
E
Y
E
K
K
Q
K
K
D
I
R
I
Q
L
N
A
Q
K
T
G
N
W
R
N
A
I
--
T
D
P
K
Y
L
A
D
L
L
K
T
R
D
D
M
------------
D
----
L
L
N
E
M
V
V
V
F
R
S
S
S
V
S
F
I
K
----
T
----
F
----------
V
S
V
G
G
L
A
N
L
M
A
I
Y
K
K
K
I
E
A
E
N
S
-----------------
N
T
A
I
D
E
E
R
K
C
C
E
V
L
R
Y
V
F
A
E
E
D
A
T
V
A
L
I
------------
E
I
D
G
G
V
E
L
L
L
K
------------
G
M
N
S
K
-
R
I
T
P
D
N
Q
L
D
I
L
L
E
----
I
T
L
T
S
-----
S
M
V
E
H
P
--
S
Q
E
G
L
Y
L
G
G
D
V
C
V
M
N
A
F
S
N
L
V
S
E
G
V
D
M
K
K
F
------
L
---------------------
S
------
F
F
-----------------
S
---
L
-------------------------
F
S
K
S
-----
K
S
E
K
F
K
H
A
S
L
V
L
I
N
N
L
I
D
Q
P
E
L
E
H
-----------------------------------
R
M
D
---
V
---
R
N
S
F
I
E
I
G
L
V
N
E
L
E
N
M
K
N
T
E
W
M
K
--------
I
D
K
I
K
D
S
I
N
D
F
F
D
S
W
E
E
D
K
K
E
V
E
S
R
F
D
D
L
18
HHSearch
41.41
25%
-37
- C4 -
2RSM
-
CL065_MOUSE
A:
[4-111]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
K
W
G
L
R
L
Q
E
K
P
A
-------
L
L
F
-
P
G
--
M
A
A
S
T
V
Q
V
A
G
R
K
D
----
Y
P
--
A
-----
L
-
L
P
L
N
--
E
S
E
L
E
E
Q
F
V
K
G
H
G
-
P
G
G
Q
A
T
N
K
T
S
N
C
-
V
V
L
------
K
---------------------
H
------
V
P
-----------------
S
---
G
-------------------------
I
V
V
K
C
H
Q
T
R
S
V
D
Q
N
R
K
I
A
R
K
V
L
Q
E
K
V
D
V
F
Y
N
S
G
P
--
S
S
--
G
-------------------------------------------------------------------------------------------------