@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0158: (2015-12-12 )
MISFKEALKIHSNIPLKPLEVEVVSLFESAGRILAEDIICVHALPKFNQSAMDGYGFKMQDLGQKTQVIQHIFAGDDVSALEVKENECVKIMTGAMVPKGIETIVPIECMLESHKDFALAPKDFKIHANIRQKGENASLNSVLVPKNTRLNYGHIALIASQGFKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGVFNMLKNYNTHFLGVLKDDKNLQLKILELQGYDVILSSAGVSVGDKDFFKDALKERNALFYYEKVNLKPGKPVTLAQLNQSIIIGLPGNPLSCLLVLRVLILPLLERLSLNKDFKLKPFKAQINAPLKLNNKRTHLILGNYSNHQFIPYNNRYESGAIQALAQVDSIALIDEGVGLVQGEIEILRFEN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.--.--.....-.70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200......--.210..--.....220-.-......230...-......240.......250.......260.......270.......280.......290.......300.......310.......-.320.......330.......340..----.--.--...350.......360.......370.......-380-.-.......390-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MI
S
F
K
E
A
L
K
IHSNIPLK
P
L
E
V
E
V
V
S
L
F
E
S
A
G
R
I
L
A
E
D
I
I
C
V
HALPKF
N
Q
S
AMDGYG
F
K
M
Q
D
L--G--
Q
K
T
Q
V
-
I
Q
H
I
FAGDD
V
S
A
L
E
VKENE
C
V
K
I
MTGAMVPKGIETIV
P
I
E
C
M
L
E
SHKDFALAPK
D
F
K
I
H
A
N
I
RQKGENASL
N
S
V
LVPKNTRLNY
G
H
I
A
L
I
A
SQ
G
F
K
E
I
K
A
F
R
K
L
K
I
A
L
FSSGD
E
L
V
PLGQN
A
L
E
C
Q
V
Y
D
VNS
V
G
V
F
N
M
L
K
--NYNT
H
F
--
L
G
V
LKDDK-N-
L
Q
L
K
I
L
E
--LQG-
Y
D
V
I
L
SSAGVSVG
D
K
D
F
F
K
D
A
L
K
ERN
A
L
F
Y
Y
E
KVNLKPGK
P
V
T
L
A
QLNQ
S
I
I
I
GLPG
N
P
L
S
C
L
L
V
L
R
V
L
I
L
P
L
L
E
R
L-SLNKDFKL-K
P
F
K
A
QINA
P
L
K
LNNK
R
T
H
L
I
L
GNYS----N--H--
Q
F
IPYNNRYE
S
G
A
I
Q
A
L
A
QV
D
S
I
A
L
IDEGVGLV-QG--
E
-
I
E
I
L
R
FEN---
32
HHSearch
90.56
33%
-94
- C4 -
1G8L
9
MOEA_ECOLI
A:
[7-405]
L
M
S
L
D
T
A
L
N
E
M
L
S
R
V
T
P
L
T
A
Q
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
--
A
S
G
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
-
G
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
M
Q
E
Q
T
E
Q
-
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
Q
L
G
C
E
V
I
N
--
L
G
I
I
R
D
D
P
H
A
-
L
R
A
A
F
I
E
A
-
D
S
Q
-
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
-
E
I
A
F
W
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
L
Q
R
---
N
AD
G
E
L
E
V
T
T
-
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
R
D
R
G
N
V
E
V
G
--
E
W
V
E
V
E
P
F
N
A
---
54
Fugue
87.64
29%
-100
- C4 -
1G8L
9
MOEA_ECOLI
A:
[7-409]
L
M
S
L
D
T
A
L
N
E
M
L
S
R
V
T
P
L
T
A
Q
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
--
A
--
S
G
Q
P
L
P
V
A
G
K
S
F
A
G
Q
P
Y
H
G
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
-
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
Q
L
G
C
E
V
I
N
--
L
G
I
I
R
D
D
P
-
H
-
A
L
R
A
A
F
I
E
A
D
S
Q
-
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
K
-
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
S
G
N
T
A
S
G
L
P
-
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
L
Q
R
N
AD
G
--
E
--
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
R
D
R
G
N
V
-
E
V
G
E
W
-
V
E
V
E
P
F
N
A
LFG
23
PsiBlast_CBE
86.64
36%
-99
- C4 -
1G8R
6
MOEA_ECOLI
B:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
AS
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
30
PsiBlast_CBE
85.92
35%
-99
- C4 -
2NQN
20
MOEA_ECOLI
B:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
AS
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
W
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
11
PsiBlast_PDB
85.37
35%
-99
- C4 -
2NQN
10
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
W
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
I
N
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
5
PsiBlast_PDB
85.18
36%
-103
- C4 -
2NRS
-
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
AS
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
W
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
1
PsiBlast_PDB
85.14
36%
-95
- C4 -
2NQR
12
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
N
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
3
PsiBlast_PDB
85.05
36%
-98
- C4 -
1G8L
7
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
8
PsiBlast_PDB
85.03
35%
-98
- C4 -
2NQQ
6
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
Q
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
7
PsiBlast_PDB
84.96
35%
-101
- C4 -
2NQU
4
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
Q
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
I
N
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
29
PsiBlast_CBE
84.79
35%
-98
- C4 -
2NQS
4
MOEA_ECOLI
B:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
AS
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
A
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
25
PsiBlast_CBE
84.75
35%
-107
- C4 -
2NQU
4
MOEA_ECOLI
B:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
Q
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
4
PsiBlast_PDB
84.70
36%
-99
- C4 -
1G8R
3
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
I
N
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
21
PsiBlast_CBE
84.47
36%
-97
- C4 -
2NQR
7
MOEA_ECOLI
B:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
AS
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
N
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
10
PsiBlast_PDB
84.42
35%
-100
- C4 -
2NQS
4
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
A
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
9
PsiBlast_PDB
84.16
35%
-99
- C4 -
2NQK
-
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
N
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
I
N
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
24
PsiBlast_CBE
84.05
36%
-94
- C4 -
1G8L
9
MOEA_ECOLI
B:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
AS
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
31
PsiBlast_CBE
84.01
35%
-99
- C4 -
2NQV
2
MOEA_ECOLI
B:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
AS
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
IN
L
G
I
I
R
A
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
13
PsiBlast_PDB
83.41
35%
-102
- C4 -
1FC5
-
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
M
Q
E
-
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
I
N
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
K
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---
6
PsiBlast_PDB
83.21
35%
-100
- C4 -
2NRO
-
MOEA_ECOLI
A:
[28-346]
---------------------
E
T
L
P
L
V
Q
C
F
G
R
I
L
A
S
D
V
V
S
P
L
D
V
P
G
F
D
N
S
A
M
D
G
Y
A
V
R
L
A
D
I
A
S
G
--
Q
P
L
P
V
-
A
G
K
S
F
A
G
Q
P
Y
H
G
-
E
W
P
A
G
T
C
I
R
I
M
T
G
A
P
V
P
E
G
C
E
A
V
V
-
M
Q
E
Q
T
E
Q
M
D
N
G
V
R
F
T
A
E
V
R
S
G
Q
N
I
R
R
R
G
E
D
I
S
A
G
A
V
V
F
P
A
G
T
R
L
T
T
A
E
L
P
V
I
A
S
L
G
I
A
E
V
P
V
I
R
K
V
R
V
A
L
F
S
T
G
D
E
L
Q
L
P
G
Q
P
L
G
D
G
Q
I
Y
D
T
N
R
L
A
V
H
L
M
L
E
--
Q
L
G
C
E
V
I
N
L
G
I
I
R
D
D
P
-
H
A
L
R
A
A
F
I
E
--
A
D
S
Q
A
D
V
V
I
S
S
G
G
V
S
V
G
E
A
D
Y
T
K
T
I
L
E
E
L
G
E
I
A
F
W
-
K
L
A
I
Q
P
G
K
P
F
A
F
G
K
L
S
N
S
W
F
C
G
L
P
G
N
P
V
S
A
T
L
T
F
Y
Q
L
V
Q
P
L
L
A
K
L
-
S
G
N
T
A
S
G
L
--
P
A
R
Q
R
V
R
T
A
S
R
L
K
K
T
P
G
R
L
D
F
Q
R
G
V
----
L
--
Q
--
R
N
A
D
G
E
L
E
V
T
T
T
G
H
Q
G
S
H
I
F
S
S
F
S
L
G
N
C
F
I
V
L
E
-
R
D
--
R
-
G
N
V
E
V
G
E
W
---