@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0178: (2015-12-13 )
MKITYCDALIIGGGLAGLRASIACKQKGLNTIVLSLVPVRRSHSAAAQGGMQASLANAKKSEGDNEDLHFLDTVKGSDWGCDQQVARMFVTTAPKAIRELASWGVPWTRIKKGDRPAVVNGEHVIITERDDRHGYILSRDFGGTKKWRTCFTADATGHTMLYAVANEALHHKVDIQDRKDMLAFIHHDNKCYGAVVRDLITGEISAYVSKGTLLATGGYGRVYKHTTNAVICDGAGAASALETGVAKLGNMEAVQFHPTALVPSGILMTEGCRGDGGVLRDKFGRRFMPAYEPEKKELASRDVVSRRILEHIQKGYGAKSPYGDHVWLDIAILGRNHVEKNLRDVRDIAMTFAGIDPADSEEQTKDNMQGAPTNEPEYGQAMAKQKGWIPIKPMQHYSMGGVRTNPKGETHLKGLFCAGEAACWDLHGFNRLGGNSVSEPVVAGMIIGDYFASHCLEAQIEINTQKVEAFIKESQDYMHFLLHNEGKEDVYEIRERMKEVMDEKVGVFREGKKLEEALKELQELYARSKNICVKNKVLHNNPELEDAYRTKKMLKLALCITQGALLRTESRGAHTRIDYPKRDDEKWLNRTLASWPSAEQDMPTIEYEELDVMKMEISPDFRGYGKKGNFIPHPKKEERDAEILKTILELEKLGKDRIEVQHALMPFELQEKYKARNMRLEDEEVRARGEHLYSFNVHDLLDQHNANLKGEHHE
Atome Classification :
(20 SA)
.........10........20......--.--.30........40........50........60........70........80........90........100.......110.---......120..-......130.......140....--------...150.......160.......-170........180...-....190.........200.......210.......220.......230.......240..-.....250.......260.......270.......280.......290-----------...-----------....300.......310.......320.......330.......340.......350-.......360.......370.......380.......390.......400..---------...----------..-410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570......--.--580.......590.......600.......610..--.....620.......630.......640.......650.......660.......670.......680.......690.......700.......710..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
T
Y
C
D
A
L
I
IGG
G
L
A
G
L
R
A
S
I
A
C
K
QK--G--L
N
T
I
V
L
S
L
VPVRRSH
S
A
A
AQGGM
Q
A
S
LANAKKSEGDNE
D
L
H
F
L
DTVKGSDWG
C
D
Q
Q
V
A
R
M
F
V
TT
A
P
K
A
I
R
E
L
A
SWGVP
W
T
RIKKG---DR
P
A
V
VN-G
E
H
-
V
I
I
T
ERDDRH
G
Y
I
L
S
RDFGGT
K
K
--------
W
R
T
C
F
TADATG
H
T
M
L
Y
A
V
A
N
E
A
L-HH-KVD
I
Q
D
R
K
D
M
L
A
F
I-HHDN
K
--
C
Y
G
A
V
V
R
D
L
I
T
G
E
I
S
A
Y
VSKG
T
L
L
A
TGGYG
R
V
Y
K
HTT
N
A
V
I
CDGAG
A
A
S
A
L
E
T
G
-
V
A
KLGN
M
E
A
V
Q
F
HPTALVPS
G
I
L
MTEGCRGDG
G
V
L
R
D
K
FGRRFMPAYE-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
I
L
E
H
I
Q
K
GYGAKSPYG
D
H
V
W
L
D
I
A
I
LG
R
N
H
V
E
K
N
L
R
D
V
R
D
I
A
M
T
F-AGIDPAD
S
E
E
Q
T
KDNMQGAPTNE
P
E
Y
G
Q
A
M
A
KQKGWIPIKP
M
Q
HYSMGGVRT---------NPK----------GE-T
H
L
K
G
L
F
CAGE
A
A
C
W
DLHG
F
N
RLGGNSVSE
P
V
V
A
G
M
I
I
G
D
Y
F
A
S
H
C
L
E
A
Q
I
E
I
N
T
Q
K
V
E
A
F
I
K
ES
Q
D
Y
M
H
F
L
LHNEGK
E
D
V
Y
E
I
R
E
R
M
K
E
V
M
D
E
K
V
G
V
F
RE
G
K
K
L
E
E
A
L
K
E
L
Q
E
L
Y
A
RSKN
I
C
V
KNKVLHNNP
E
L
E
D
A
Y
R
T
K
K
M
L
K
L
A
L
C
ITQG
A
L
L
RTESRGAHTRID--Y--PKR
D
D
E
K
W
L
N
R
T
L
ASWPSAEQDMPT
I
E
Y
EE
L
D
V
M
K
--
M
E
ISPDFRGYGKKGNFIPHPK
K
E
E
R
D
A
E
I
L
K
T
I
L
E
L
E
K
LG
K
D
R
I
E
V
Q
HALM
P
F
E
L
Q
E
K
Y
K
ARNMRL
E
D
E
E
V
R
ARG
E
H
L
Y
S
F
N
V
H
D
L
L
D
QHNANLKGEHHE
5
PsiBlast_PDB
96.33
67%
-62
- C3 -
1QLB
3
FRDA_WOLSU
A:
[1-655]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
S
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
R
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
--------------------------------
27
PsiBlast_CBE
96.06
67%
-62
- C3 -
1QLB
3
FRDA_WOLSU
D:
[1-655]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
S
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
R
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
--------------------------------
102
Fugue
95.58
70%
-58
- C3 -
1E7P
1
FRDA_WOLSU
A:
[1-655]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
---------------------------
A
E
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
--------------------------------
2
PsiBlast_PDB
94.78
67%
-58
- C3 -
1E7P
1
FRDA_WOLSU
A:
[1-655]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
--------------------------------
26
PsiBlast_CBE
94.22
67%
-58
- C3 -
1E7P
1
FRDA_WOLSU
D:
[1-655]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
--------------------------------
25
PsiBlast_CBE
94.17
67%
-58
- C3 -
1E7P
3
FRDA_WOLSU
G:
[1-655]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
--------------------------------
24
PsiBlast_CBE
94.11
67%
-58
- C3 -
1E7P
1
FRDA_WOLSU
J:
[1-655]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
--------------------------------
3
PsiBlast_PDB
84.17
67%
-5
- C- -
2BS3
3
FRDA_WOLSU
A:
[1-656]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
K
-------------------------------
23
PsiBlast_CBE
84.15
67%
-5
- C- -
2BS3
3
FRDA_WOLSU
D:
[1-656]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
K
-------------------------------
1
PsiBlast_PDB
84.12
67%
-5
- C- -
2BS2
3
FRDA_WOLSU
A:
[1-656]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
K
-------------------------------
21
PsiBlast_CBE
84.10
67%
-6
- C- -
2BS2
3
FRDA_WOLSU
D:
[1-656]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
K
-------------------------------
4
PsiBlast_PDB
83.88
67%
-5
- C- -
2BS4
3
FRDA_WOLSU
A:
[1-656]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
K
-------------------------------
22
PsiBlast_CBE
83.33
67%
-5
- C- -
2BS4
3
FRDA_WOLSU
D:
[1-656]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
-
A
Q
K
-
T
T
I
T
E
E
D
F
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
-
I
A
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
L
R
D
V
Q
E
I
C
E
Y
F
-
A
G
I
D
P
A
E
K
---------------------------
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
P
T
L
E
Y
E
A
L
D
V
N
E
--
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
K
-------------------------------
112
HHSearch
82.68
68%
-4
- C- -
2BS2
3
FRDA_WOLSU
A:
[1-656]
M
K
V
Q
Y
C
D
S
L
V
I
G
G
G
L
A
G
L
R
A
A
V
A
T
Q
Q
K
--
G
--
L
S
T
I
V
L
S
L
I
P
V
K
R
S
H
S
A
A
A
Q
G
G
M
Q
A
S
L
G
N
S
K
M
S
D
G
D
N
E
D
L
H
F
M
D
T
V
K
G
S
D
W
G
C
D
Q
K
V
A
R
M
F
V
N
T
A
P
K
A
I
R
E
L
A
A
W
G
V
P
W
T
R
I
H
K
G
---
D
R
M
A
I
I
N
A
Q
K
T
T
I
T
E
E
D
F
--
R
H
G
L
I
H
S
R
D
F
G
G
T
K
K
--------
W
R
T
C
Y
T
A
D
A
T
G
H
T
M
L
F
A
V
A
N
E
C
L
-
K
L
-
G
V
S
I
Q
D
R
K
E
A
I
A
L
I
-
H
Q
D
G
K
--
C
Y
G
A
V
V
R
D
L
V
T
G
D
I
I
A
Y
V
A
K
G
T
L
I
A
T
G
G
Y
G
R
I
Y
K
N
T
T
N
A
V
V
C
E
G
T
G
T
A
I
A
L
E
T
G
I
A
-
Q
L
G
N
M
E
A
V
Q
F
H
P
T
P
L
F
P
S
G
I
L
L
T
E
G
C
R
G
D
G
G
I
L
R
D
V
D
G
H
R
F
M
P
D
Y
E
-----------
P
E
K
-----------
K
E
L
A
S
R
D
V
V
S
R
R
M
I
E
H
I
R
K
G
K
G
V
Q
S
P
Y
G
Q
H
L
W
L
D
I
S
I
L
G
R
K
H
I
E
T
N
-
L
R
D
V
Q
E
I
C
E
Y
F
A
G
I
D
P
A
E
---------------------------
K
W
A
P
V
L
P
M
Q
H
Y
S
M
G
G
I
R
T
---------
D
Y
R
----------
G
E
-
A
K
L
K
G
L
F
S
A
G
E
A
A
C
W
D
M
H
G
F
N
R
L
G
G
N
S
V
S
E
A
V
V
A
G
M
I
V
G
E
Y
F
A
E
H
C
A
N
T
Q
V
D
L
E
T
K
T
L
E
K
F
V
K
G
Q
E
A
Y
M
K
S
L
V
E
S
K
G
T
E
D
V
F
K
I
K
N
R
M
K
D
V
M
D
D
N
V
G
I
F
R
D
G
P
H
L
E
K
A
V
K
E
L
E
E
L
Y
K
K
S
K
N
V
G
I
K
N
K
R
L
H
A
N
P
E
L
E
E
A
Y
R
V
P
M
M
L
K
V
A
L
C
V
A
K
G
A
L
D
R
T
E
S
R
G
A
H
N
R
E
D
--
Y
--
P
K
R
D
D
I
N
W
L
N
R
T
L
A
S
W
P
N
P
E
Q
T
L
--
P
T
L
E
Y
E
A
L
D
V
NE
M
E
I
A
P
G
Y
R
G
Y
G
A
K
G
N
Y
I
E
N
P
L
S
V
K
R
Q
E
E
I
D
K
I
Q
S
E
L
E
A
A
G
K
D
R
H
A
I
Q
E
A
L
M
P
Y
E
L
P
A
K
Y
K
A
R
N
E
R
L
G
D
K
-------------------------------
103
Fugue
79.62
36%
-60
- C3 -
1L0V
2
FRDA_ECOLI
A:
[1-577]
M
Q
T
F
Q
A
D
L
A
I
V
G
A
G
G
A
G
L
R
A
A
I
A
A
A
Q
A
--
N
PN
A
K
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
S
A
A
V
A
-----
Q
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
D
G
---
S
V
N
-----------------------
V
R
R
F
G
G
M
K
I
--------
E
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
-
Q
F
P
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
-
V
D
D
--GH
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
P
-
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
M
T
E
G
C
R
G
E
G
G
I
L
V
N
K
N
G
Y
R
Y
L
Q
D
Y
G
MGPETPLG
E
P
K
N
K
Y
-----------
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
I
S
T
P
R
G
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
K
A
Y
-
V
G
V
D
P
V
K
E
P
---------------------------
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
---------
D
Q
N
----------
C
E
-
T
R
I
K
G
L
F
A
V
G
E
C
S
S
V
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
G
-
N
G
N
E
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
D
--
E
GC
T
E
R
D
D
V
N
F
L
K
H
T
L
A
F
R
D
A
D
G
T
--
T
R
L
E
Y
S
D
V
K
I
T
T
--
L
P
P
A
------------------------------------------------------------------------------------------------
113
HHSearch
78.81
36%
-61
- C3 -
1KF6
5
FRDA_ECOLI
A:
[1-577]
M
Q
T
F
Q
A
D
L
A
I
V
G
A
G
G
A
G
L
R
A
A
I
A
A
A
Q
A
NP
N
--
A
K
I
A
L
I
S
K
V
Y
P
M
R
S
H
T
V
A
A
E
G
G
S
A
A
V
A
Q
-----
D
H
D
S
F
E
Y
H
F
H
D
T
V
A
G
G
D
W
L
C
E
Q
D
V
V
D
Y
F
V
H
H
C
P
T
E
M
T
Q
L
E
L
W
G
C
P
W
S
R
R
P
--------------------------
D
G
S
V
N
V
R
R
F
G
G
M
K
I
--------
E
R
T
W
F
A
A
D
K
T
G
F
H
M
L
H
T
L
F
Q
T
S
L
Q
F
P
-
Q
I
Q
R
F
D
E
H
F
V
L
D
I
L
-
V
D
D
G
H
--
V
R
G
L
V
A
M
N
M
M
E
G
T
L
V
Q
I
R
A
N
A
V
V
M
A
T
G
G
A
G
R
V
Y
R
Y
N
T
N
G
G
I
V
T
G
D
G
M
G
M
A
L
S
H
G
-
V
-
P
L
R
D
M
E
F
V
Q
Y
H
P
T
G
L
P
G
S
G
I
L
M
T
E
G
C
R
G
E
G
G
I
L
V
N
K
N
G
Y
R
Y
L
Q
D
Y
G
-----------
M
G
P
ETPLG
E
P
K
N
KY
M
E
L
G
P
R
D
K
V
S
Q
A
F
W
H
E
W
R
K
G
N
T
I
S
T
P
R
G
D
V
V
Y
L
D
L
R
H
L
G
E
K
K
L
H
E
R
L
P
F
I
C
E
L
A
K
A
Y
-
V
G
V
D
P
V
K
---------------------------
E
P
I
P
V
R
P
T
A
H
Y
T
M
G
G
I
E
T
---------
D
Q
N
----------
C
E
-
T
R
I
K
G
L
F
A
V
G
E
C
S
S
V
G
L
H
G
A
N
R
L
G
S
N
S
L
A
E
L
V
V
F
G
R
L
A
G
E
Q
A
T
E
R
A
A
T
A
G
N
G
N
E
-
A
A
I
E
A
Q
A
A
G
V
E
Q
R
L
K
D
L
V
N
Q
D
G
G
E
N
W
A
K
I
R
D
E
M
G
L
A
M
E
E
G
C
G
I
Y
R
T
P
E
L
M
Q
K
T
I
D
K
L
A
E
L
Q
E
R
F
K
R
V
R
I
T
D
T
S
S
V
F
N
T
D
L
L
Y
T
I
E
L
G
H
G
L
N
V
A
E
C
M
A
H
S
A
M
A
R
K
E
S
R
G
A
H
Q
R
L
D
EG
C
--
T
E
R
D
D
V
N
F
L
K
H
T
L
A
F
R
D
A
D
G
T
----
T
R
L
E
Y
S
D
V
K
I
--
T
T
L
P
P
A
----------------------------------------------------------------------------------------------
98
PsiBlast_CBE
76.28
34%
-61
- C3 -
4YSY
2
?
A:
[43-584]
------
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
G
L
G
E
A
--
G
--
F
K
T
A
V
V
T
K
M
F
P
T
R
S
H
T
T
A
A
Q
G
G
I
N
A
A
L
G
S
M
N
P
---
D
D
W
K
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
M
P
F
S
R
T
P
E
G
---
K
-----------------------
I
Y
Q
R
S
F
G
G
Q
S
N
NYGKGGVA
K
R
T
C
C
V
A
D
R
T
G
H
S
M
L
H
T
L
Y
G
N
S
L
-
R
C
-
H
C
T
F
F
I
E
Y
F
A
L
D
L
L
-
M
D
K
G
R
--
C
V
G
V
I
A
L
C
L
E
D
G
T
I
H
R
F
R
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
-
I
A
-
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
A
-----------
P
K
A
-----------
K
D
L
A
S
R
D
V
V
S
R
A
E
T
I
E
I
M
E
G
R
G
V
-
G
P
E
K
D
H
I
Y
L
Q
L
H
H
L
P
A
E
Q
L
H
Q
R
L
P
G
I
S
E
T
A
K
I
F
-
A
G
V
D
---------------
V
T
K
E
P
------------
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
---------
N
Y
K
A
Q
V
I
K
Y
T
KEG
G
D
-
K
I
V
P
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
R
A
C
S
I
N
I
K
E
E
-
L
K
P
D
E
K
I
-
P
E
L
P
E
G
A
G
E
E
S
I
A
N
L
D
A
V
R
Y
A
N
G
D
V
P
T
A
E
L
R
L
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
R
G
D
I
L
A
E
G
V
K
K
M
M
D
L
F
K
E
L
K
R
L
K
T
T
D
R
S
L
I
W
N
S
D
L
T
E
S
L
E
L
Q
N
L
M
L
N
A
T
Q
T
I
V
A
A
E
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
Y
D
Y
S
K
P
I
E
G
Q
T
K
R
P
F
E
K
H
W
R
K
H
T
L
T
K
Q
D
P
--
R
T
G
H
I
T
L
D
Y
R
P
V
I
D
K
T
L
D
P
A
E
V
D
W
I
P
P
I
I
R
S
Y
--------------------------------------------------------------------
14
PsiBlast_PDB
76.07
35%
-50
- C3 -
2WU2
3
SDHA_ECOLI
A:
[9-558]
------
D
A
V
V
I
G
A
G
G
A
G
M
R
A
A
L
Q
I
S
Q
S
--
G
--
Q
T
C
A
L
L
S
K
V
F
P
T
R
S
H
T
V
S
A
Q
G
G
I
T
V
A
L
G
N
T
H
E
---
D
N
W
E
W
H
M
Y
D
T
V
K
G
S
D
Y
I
G
D
Q
D
A
I
E
Y
M
C
K
T
G
P
E
A
I
L
E
L
E
H
M
G
L
P
F
S
R
L
D
D
G
R
I
Y
Q
R
P
--
F
G
-
G
Q
----------------
S
K
N
F
G
G
E
Q
A
--------
A
R
T
A
A
A
A
D
R
T
G
H
A
L
L
H
T
L
Y
Q
Q
N
L
-
K
N
-
H
T
T
I
F
S
E
W
Y
A
L
D
L
V
K
N
Q
D
G
A
--
V
V
G
C
T
A
L
C
I
E
T
G
E
V
V
Y
F
K
A
R
A
T
V
L
A
T
G
G
A
G
R
I
Y
Q
S
T
T
N
A
H
I
N
T
G
D
G
V
G
M
A
I
R
A
G
-
V
-
P
V
Q
D
M
E
M
W
Q
F
H
P
T
G
I
A
G
A
G
V
L
V
T
E
G
C
R
G
E
G
G
Y
L
L
N
K
H
G
E
R
F
M
E
R
Y
A
-----------
P
N
A
-----------
K
D
L
A
G
R
D
V
V
A
R
S
I
M
I
E
I
R
E
G
R
G
C
D
G
P
W
G
P
H
A
K
L
K
L
D
H
L
G
K
E
V
L
E
S
R
L
P
G
I
L
E
L
S
R
T
F
-
A
H
V
D
---------------
P
V
K
E
P
------------
I
P
V
I
P
T
C
H
Y
M
M
G
G
I
P
T
KVTG
Q
A
L
T
V
N
E
K
----------
G
E
D
V
V
V
P
G
L
F
A
V
G
E
I
A
C
V
S
V
H
G
A
N
R
L
G
G
N
S
L
L
D
L
V
V
F
G
R
A
A
G
L
H
L
Q
E
S
I
A
E
Q
G
A
L
R
D
A
S
--
E
S
D
V
E
A
S
L
D
R
L
N
R
W
N
N
N
R
N
G
E
D
P
V
A
I
R
K
A
L
Q
E
C
M
Q
H
N
F
S
V
F
R
E
G
D
A
M
A
K
G
L
E
Q
L
K
V
I
R
E
R
L
K
N
A
R
L
D
D
T
S
S
E
F
N
T
Q
R
V
E
C
L
E
L
D
N
L
M
E
T
A
Y
A
T
A
V
S
A
N
F
R
T
E
S
R
G
A
H
S
R
F
D
--
F
--
P
D
R
D
D
E
N
W
L
C
H
S
L
Y
L
P
E
S
E
S
M
T
R
R
S
V
N
M
E
P
K
L
R
P
A
--
F
P
P
K
I
R
T
Y
--------------------------------------------------------------------------------------------
97
PsiBlast_CBE
75.87
34%
-61
- C3 -
4YSY
2
?
E:
[43-584]
------
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
G
L
G
E
A
--
G
--
F
K
T
A
V
V
T
K
M
F
P
T
R
S
H
T
T
A
A
Q
G
G
I
N
A
A
L
G
S
M
N
P
---
D
D
W
K
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
M
P
F
S
R
T
P
E
G
---
K
-----------------------
I
Y
Q
R
S
F
G
G
Q
S
N
NYGKGGVA
K
R
T
C
C
V
A
D
R
T
G
H
S
M
L
H
T
L
Y
G
N
S
L
-
R
C
-
H
C
T
F
F
I
E
Y
F
A
L
D
L
L
-
M
D
K
G
R
--
C
V
G
V
I
A
L
C
L
E
D
G
T
I
H
R
F
R
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
-
I
A
-
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
A
-----------
P
K
A
-----------
K
D
L
A
S
R
D
V
V
S
R
A
E
T
I
E
I
M
E
G
R
G
V
-
G
P
E
K
D
H
I
Y
L
Q
L
H
H
L
P
A
E
Q
L
H
Q
R
L
P
G
I
S
E
T
A
K
I
F
-
A
G
V
D
---------------
V
T
K
E
P
------------
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
---------
N
Y
K
AQVIKYTKEG
G
D
-
K
I
V
P
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
R
A
C
S
I
N
I
K
E
E
-
L
K
P
D
E
K
I
-
P
E
L
P
E
G
A
G
E
E
S
I
A
N
L
D
A
V
R
Y
A
N
G
D
V
P
T
A
E
L
R
L
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
R
G
D
I
L
A
E
G
V
K
K
M
M
D
L
F
K
E
L
K
R
L
K
T
T
D
R
S
L
I
W
N
S
D
L
T
E
S
L
E
L
Q
N
L
M
L
N
A
T
Q
T
I
V
A
A
E
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
Y
D
Y
S
K
P
I
E
G
Q
T
K
R
P
F
E
K
H
W
R
K
H
T
L
T
K
Q
D
P
--
R
T
G
H
I
T
L
D
Y
R
P
V
I
D
K
T
L
D
P
A
E
V
D
W
I
P
P
I
I
R
S
Y
--------------------------------------------------------------------
95
PsiBlast_CBE
75.86
34%
-61
- C3 -
4YSZ
2
?
E:
[43-584]
------
D
V
V
I
I
G
A
G
G
A
G
L
R
A
A
M
G
L
G
E
A
--
G
--
F
K
T
A
V
V
T
K
M
F
P
T
R
S
H
T
T
A
A
Q
G
G
I
N
A
A
L
G
S
M
N
P
---
D
D
W
K
W
H
F
Y
D
T
V
K
G
S
D
W
L
G
D
Q
N
A
M
H
Y
L
T
R
N
A
V
E
A
V
T
E
L
E
N
F
G
M
P
F
S
R
T
P
E
G
---
K
-----------------------
I
Y
Q
R
S
F
G
G
Q
S
N
NYGKGGVA
K
R
T
C
C
V
A
D
R
T
G
H
S
M
L
H
T
L
Y
G
N
S
L
-
R
C
-
H
C
T
F
F
I
E
Y
F
A
L
D
L
L
-
M
D
K
G
R
--
C
V
G
V
I
A
L
C
L
E
D
G
T
I
H
R
F
R
S
K
R
T
I
V
A
T
G
G
Y
G
R
A
Y
F
S
C
T
T
A
H
M
N
T
G
D
G
T
A
L
A
T
R
A
G
-
I
A
-
L
E
D
L
E
F
I
Q
F
H
P
T
G
I
Y
G
V
G
C
L
I
T
E
G
S
R
G
E
G
G
F
L
V
N
S
E
G
E
R
F
M
E
R
Y
A
-----------
P
K
A
-----------
K
D
L
A
S
R
D
V
V
S
R
A
E
T
I
E
I
M
E
G
R
G
V
-
G
P
E
K
D
H
I
Y
L
Q
L
H
H
L
P
A
E
Q
L
H
Q
R
L
P
G
I
S
E
T
A
K
I
F
-
A
G
V
D
---------------
V
T
K
E
P
------------
I
P
V
I
P
T
V
H
Y
N
M
G
G
I
P
T
---------
N
Y
K
AQVIKYTKEG
G
D
-
K
I
V
P
G
L
Y
A
C
G
E
C
A
C
H
S
V
H
G
A
N
R
L
G
A
N
S
L
L
D
A
V
V
F
G
R
A
C
S
I
N
I
K
E
E
-
L
K
P
D
E
K
I
-
P
E
L
P
E
G
A
G
E
E
S
I
A
N
L
D
A
V
R
Y
A
N
G
D
V
P
T
A
E
L
R
L
T
M
Q
K
T
M
Q
K
H
A
G
V
F
R
R
G
D
I
L
A
E
G
V
K
K
M
M
D
L
F
K
E
L
K
R
L
K
T
T
D
R
S
L
I
W
N
S
D
L
T
E
S
L
E
L
Q
N
L
M
L
N
A
T
Q
T
I
V
A
A
E
N
R
K
E
S
R
G
A
H
A
R
D
D
--
F
--
P
K
R
E
D
E
Y
D
Y
S
K
P
I
E
G
Q
T
K
R
P
F
E
K
H
W
R
K
H
T
L
T
K
Q
D
P
--
R
T
G
H
I
T
L
D
Y
R
P
V
I
D
K
T
L
D
P
A
E
V
D
W
I
P
P
I
I
R
S
Y
--------------------------------------------------------------------