@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0180: (2015-12-13 )
MTKIAMANFKSAMPVFKSHAYLKELEKTLKPQHFDRVFVFPDFLGLLPNAFLHFTLGAQNAYPRDCGAFTGEITSKHLEELKIHTLLIGHSERRVLLKESPSFLKEKFDFFKGKNFKIVYCIGEDLTTREKGFRAVKEFLSEQLENIDLNYSNLIVAYEPIWAIGTKKSASLEDIYLTHGFLKQILNQKTPLLYGGSVNAQNAKEILGIDSVDGLLIGSASLELENFKTIISFL
Atome Classification :
(59 SA)
--.......-..10........20........30....---..--..40..-...------...50---.-----.----.-----..---------....60........70........80........90........100.......110.......120.......130---------.......140---...-----.-----.-----.-.--150-..-----.......160.......170....-...----180.----.--------..--------.--------.--------.--------190-------........200.......210.......220.......230..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MT
K
I
AM
A
-
N
F
K
S
A
M
P
V
F
K
S
H
A
Y
L
K
E
L
E
K
TLK
P
Q
HF
D
---
R
V
--
F
V
F
P
D
F
-
L
G
L------LP
N
A
----
F
-----
L
----
H
-----
F
T
---------LGAQNAYPRDCGAF
T
G
E
I
T
S
K
H
L
E
EL
K
I
H
T
L
L
IGHSE
R
R
V
L
LKE
S
P
S
F
L
K
E
K
F
D
F
FKGK
N
F
K
I
V
Y
C
IGEDL
T
T
R
E
K
G
---------
F
R
A
V
K
E
F
L
S
E
---
Q
L
E
-----N-----I-----D-L--N---YS-----
N
L
I
V
A
YE
P
I
W
A
IGTKKSAS
L
E
D
I
Y
-
L
T
H
----
G
F
L
K
----
Q
--------
I
L--------N--------Q--------K--------T
P
--------
L
L
YGGSVNAQ
N
A
K
E
I
LGIDSVD
G
L
L
IGS
A
S
L
E
L
E
N
F
K
T
I
I
SFL-
21
PsiBlast_CBE
84.28
94%
-54
- C- -
2JGQ
1
TPIS_HELPY
B:
[1-233]
---
T
K
I
A
M
A
-
N
F
K
S
A
M
P
I
F
K
S
H
A
Y
L
K
E
L
E
K
T
L
K
P
Q
H
F
D
---
R
V
--
F
V
F
P
D
F
-
F
G
L
------
L
P
N
S
----
F
-----
L
----
H
-----
F
T
---------
L
G
V
Q
N
A
Y
P
R
D
C
G
A
F
T
G
E
I
T
S
K
H
L
E
E
L
K
I
H
T
L
L
I
G
H
S
E
R
R
T
L
L
K
E
S
P
S
F
L
K
E
K
F
D
F
F
K
S
K
N
F
K
I
V
Y
C
I
G
E
E
L
T
T
R
E
K
G
---------
F
K
A
V
K
E
F
L
S
E
---
Q
L
E
-----
N
-----
I
-----
D
-
L
--
N
---
Y
P
-----
N
L
V
V
A
Y
E
P
I
W
A
I
G
T
-
K
S
A
S
L
E
D
I
Y
-
L
T
H
----
G
F
L
K
----
Q
--------
I
L
--------
N
--------
Q
--------
K
--------
T
P
--------
L
L
Y
G
G
S
V
N
T
Q
N
A
K
E
I
L
G
I
D
S
V
D
G
L
L
I
G
S
A
S
W
E
L
E
N
F
K
T
I
I
S
F
L
-
121
HHSearch
83.98
95%
-56
- C- -
2JGQ
2
TPIS_HELPY
A:
[1-233]
---
T
K
I
A
M
A
-
N
F
K
S
A
M
P
I
F
K
S
H
A
Y
L
K
E
L
E
K
T
L
K
P
Q
H
F
D
---
R
V
--
F
V
F
P
D
F
-
F
G
L
------
L
P
N
S
----
F
-----
L
----
H
-----
F
T
---------
L
G
V
Q
N
A
Y
P
R
D
C
G
A
F
T
G
E
I
T
S
K
H
L
E
E
L
K
I
H
T
L
L
I
G
H
S
E
R
R
T
L
L
K
E
S
P
S
F
L
K
E
K
F
D
F
F
K
S
K
N
F
K
I
V
Y
C
I
G
E
E
L
T
T
R
E
K
G
---------
F
K
A
V
K
E
F
L
S
E
---
Q
L
E
-----
N
-----
I
-----
D
-
L
--
N
---
Y
P
-----
N
L
V
V
A
Y
E
P
I
W
A
I
G
T
-
K
S
A
S
L
E
D
I
Y
-
L
T
H
----
G
F
L
K
----
Q
--------
I
L
--------
N
--------
Q
--------
K
--------
T
P
--------
L
L
Y
G
G
S
V
N
T
Q
N
A
K
E
I
L
G
I
D
S
V
D
G
L
L
I
G
S
A
S
W
E
L
E
N
F
K
T
I
I
S
F
L
-
1
PsiBlast_PDB
83.74
94%
-56
- C- -
2JGQ
2
TPIS_HELPY
A:
[1-233]
---
T
K
I
A
M
A
-
N
F
K
S
A
M
P
I
F
K
S
H
A
Y
L
K
E
L
E
K
T
L
K
P
Q
H
F
D
---
R
V
--
F
V
F
P
D
F
-
F
G
L
------
L
P
N
S
----
F
-----
L
----
H
-----
F
T
---------
L
G
V
Q
N
A
Y
P
R
D
C
G
A
F
T
G
E
I
T
S
K
H
L
E
E
L
K
I
H
T
L
L
I
G
H
S
E
R
R
T
L
L
K
E
S
P
S
F
L
K
E
K
F
D
F
F
K
S
K
N
F
K
I
V
Y
C
I
G
E
E
L
T
T
R
E
K
G
---------
F
K
A
V
K
E
F
L
S
E
---
Q
L
E
-----
N
-----
I
-----
D
-
L
--
N
---
Y
P
-----
N
L
V
V
A
Y
E
P
I
W
A
I
G
T
-
K
S
A
S
L
E
D
I
Y
-
L
T
H
----
G
F
L
K
----
Q
--------
I
L
--------
N
--------
Q
--------
K
--------
T
P
--------
L
L
Y
G
G
S
V
N
T
Q
N
A
K
E
I
L
G
I
D
S
V
D
G
L
L
I
G
S
A
S
W
E
L
E
N
F
K
T
I
I
S
F
L
-
65
PsiBlast_CBE
79.79
31%
-103
- C9 -
3UWW
3
TPIS_STAAR
A:
[11-253]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
A
D
L
SS
K
E
V
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
67
PsiBlast_CBE
79.15
31%
-103
- C9 -
3UWV
5
TPIS_STAAR
A:
[11-253]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
A
D
L
SS
K
E
V
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
63
PsiBlast_CBE
79.06
31%
-104
- C9 -
3UWZ
1
TPIS_STAAR
A:
[11-253]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
A
D
L
SS
K
E
V
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
71
PsiBlast_CBE
78.93
31%
-107
- C9 -
3M9Y
2
TPIS_STAAR
A:
[4-246]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
--
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
A
D
L
SS
K
E
V
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
64
PsiBlast_CBE
78.81
31%
-99
- C9 -
3UWW
3
TPIS_STAAR
B:
[11-253]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
A
D
L
SS
K
E
V
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
66
PsiBlast_CBE
78.49
31%
-103
- C9 -
3UWV
4
TPIS_STAAR
B:
[11-253]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
A
D
L
SS
K
E
V
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
69
PsiBlast_CBE
78.47
31%
-102
- C9 -
3UWU
2
TPIS_STAAR
A:
[11-253]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
A
D
L
SS
K
E
V
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
68
PsiBlast_CBE
78.44
31%
-101
- C9 -
3UWU
1
TPIS_STAAR
B:
[11-253]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
EDQLK
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
ADLSSKEV
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
62
PsiBlast_CBE
78.32
31%
-105
- C9 -
3UWZ
2
TPIS_STAAR
B:
[11-253]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
---
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
A
D
L
SS
K
E
V
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
70
PsiBlast_CBE
78.29
31%
-103
- C9 -
3M9Y
3
TPIS_STAAR
B:
[4-246]
---
T
P
I
I
A
G
-
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
P
T
L
P
D
S
K
E
V
E
---
S
V
--
I
C
A
P
A
I
Q
L
D
A
------
L
T
T
A
----
V
-----
K
----
E
GKAQG
L
E
---------
I
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
-----------
K
A
N
D
V
V
G
E
---
Q
V
K
-----
K
-----
A
-----
V
-
A
--
G
---
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
-
E
M
C
----
A
F
V
R
----
Q
--------
T
I
A
D
L
SS
K
E
V
S
--------
E
--------
A
--------
T
R
--------
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
5
PsiBlast_PDB
77.64
33%
-95
- C9 -
1YYA
7
TPIS_THET8
A:
[1-248]
--
M
R
R
V
L
V
A
G
N
W
K
M
H
K
T
P
S
E
A
R
V
W
F
A
E
L
K
R
L
L
P
P
L
Q
S
E
----
A
--
A
V
L
P
A
F
-
P
-
I
------
L
P
V
A
----
K
E
V
LAE
T
----
Q
-----
V
G
---------
Y
G
A
Q
D
V
S
A
H
K
E
G
A
Y
T
G
E
V
S
A
R
M
L
S
D
L
G
C
R
Y
A
I
V
G
H
S
E
R
R
R
Y
H
G
E
T
D
A
L
V
A
E
K
A
K
R
L
L
E
E
G
I
T
P
I
L
C
V
G
E
P
L
E
V
R
E
K
G
----------
E
A
V
P
Y
T
L
R
Q
L
R
G
S
L
E
-----
G
-----
V
-----
E
P
P
--
G
---
P
E
-----
A
L
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
N
A
T
P
E
D
A
E
-
A
M
H
----
Q
A
I
R
----
K
--------
A
L
--------
S
--------
E
R
YG
E
A
F
A
S
R
--------
V
R
--------
I
L
Y
G
G
S
V
N
P
K
N
F
A
D
L
L
S
M
P
N
V
D
G
G
L
V
G
G
A
S
L
E
L
E
S
F
L
A
L
L
R
I
A
-
18
PsiBlast_PDB
77.01
31%
-90
- C9 -
4MKN
6
?
A:
[25-262]
--------
G
-
N
W
K
C
N
G
S
V
A
N
V
A
K
L
V
D
E
L
N
A
G
T
I
P
R
G
V
D
----
V
--
V
V
A
P
P
F
-
I
-
Y
------
I
D
Y
V
----
M
-----
Q
----
H
LDRDK
Y
Q
---------
L
S
A
Q
N
A
W
I
G
G
N
G
A
F
T
G
E
V
S
A
E
Q
L
T
D
F
G
V
P
W
V
I
L
G
H
S
E
R
R
S
L
F
G
E
S
N
E
V
V
A
K
K
T
S
H
A
L
A
A
G
L
G
V
I
A
C
I
G
E
T
L
E
Q
R
N
S
G
S
V
-------
F
K
V
L
D
A
Q
M
D
A
---
L
V
D
-----
E
-----
V
-----
K
----
D
---
W
T
-----
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
V
V
A
S
P
E
Q
A
Q
-
E
V
H
----
A
Y
L
R
----
Q
Y
C
A
K
K
LG
A
A
V
--------
A
--------
D
--------
K
--------
L
R
--------
I
I
Y
G
G
S
V
S
D
T
N
C
K
D
L
S
K
Q
E
D
I
D
G
F
L
V
G
G
A
S
L
K
G
A
A
F
V
T
I
C
N
A
A
-
27
PsiBlast_CBE
76.98
33%
-96
- C9 -
1YYA
5
TPIS_THET8
B:
[1-248]
--
M
R
R
V
L
V
A
G
N
W
K
M
H
K
T
P
S
E
A
R
V
W
F
A
E
L
K
R
L
L
P
P
L
Q
S
E
----
A
--
A
V
L
P
A
F
-
P
-
I
------
L
P
V
A
----
K
EVLAE
T
----
Q
-----
V
G
---------
Y
G
A
Q
D
V
S
A
H
K
E
G
A
Y
T
G
E
V
S
A
R
M
L
S
D
L
G
C
R
Y
A
I
V
G
H
S
E
R
R
R
Y
H
G
E
T
D
A
L
V
A
E
K
A
K
R
L
L
E
E
G
I
T
P
I
L
C
V
G
E
P
L
E
V
R
E
K
G
----------
E
A
V
P
Y
T
L
R
Q
LRG
S
L
E
-----
G
-----
V
-----
E
P
P
--
G
---
P
E
-----
A
L
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
N
A
T
P
E
D
A
E
-
A
M
H
----
Q
A
I
R
----
K
--------
A
L
--------
S
--------
E
RYGEAFAS
R
--------
V
R
--------
I
L
Y
G
G
S
V
N
P
K
N
F
A
D
L
L
S
M
P
N
V
D
G
G
L
V
G
G
A
S
L
E
L
E
S
F
L
A
L
L
R
I
A
-
86
PsiBlast_CBE
75.74
33%
-105
- C9 -
4HHP
2
?
A:
[8-242]
-----
I
A
A
A
-
N
W
K
C
N
----
G
S
E
S
L
L
V
P
L
I
E
T
L
N
A
A
T
F
D
H
D
V
Q
C
--
V
V
A
P
T
F
-
L
H
I
P
-----
M
T
K
A
----
R
-----
L
TNP-
K
-----
F
Q
---------
I
A
A
Q
N
A
I
T
R
S
-
G
A
F
T
G
E
V
S
L
Q
I
L
K
D
Y
G
I
S
W
V
V
L
G
H
S
E
R
R
L
Y
Y
G
D
T
N
E
I
V
A
E
K
V
A
Q
A
C
A
A
G
F
H
V
I
V
C
V
G
E
T
N
E
E
R
E
A
G
R
T
A
A
V
V
L
T
Q
L
A
A
V
A
Q
K
L
S
K
---
E
A
---------------------------
W
S
-----
R
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
-
E
V
H
----
E
L
L
R
----
R
--------
W
V
--------
R
--------
S
--------
K
LG
T
D
I
A
A
Q
L
R
--------
I
L
Y
G
G
S
V
T
A
K
N
A
R
T
L
Y
Q
M
R
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
F
V
E
I
I
E
A
T
K
-
45
PsiBlast_CBE
75.32
33%
-109
- C9 -
1CI1
3
TPIS_TRYCR
B:
[8-242]
-----
I
A
A
A
-
N
W
K
C
N
----
G
S
E
S
L
L
V
P
L
I
E
T
L
N
A
A
T
F
D
H
D
V
Q
C
--
V
V
A
P
T
F
-
L
H
I
P
-----
M
T
K
A
----
R
-----
L
TNP-
K
-----
F
Q
---------
I
A
A
Q
N
A
I
T
R
S
-
G
A
F
T
G
E
V
S
L
Q
I
L
K
D
Y
G
I
S
W
V
V
L
G
H
S
E
R
R
L
Y
Y
G
E
T
N
E
I
V
A
E
K
V
A
Q
A
C
A
A
G
F
H
V
I
V
C
V
G
E
T
N
E
E
R
E
A
G
R
T
A
A
V
V
L
T
Q
L
A
A
V
A
Q
K
L
S
K
---
E
A
---------------------------
W
S
-----
R
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
-
E
V
H
----
E
L
L
R
----
R
--------
W
V
--------
R
--------
S
--------
K
LG
T
D
I
A
A
Q
L
R
--------
I
L
Y
G
G
S
V
T
A
K
N
A
R
T
L
Y
Q
M
R
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
F
V
E
I
I
E
A
T
K
-
101
Fugue
75.06
34%
-94
- C9 -
1YPI
-
TPIS_YEAST
A:
[2-248]
-A
R
T
F
F
V
G
G
-
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
S
I
P
E
-
N
V
---
E
V
--
V
I
C
P
P
A
-
T
Y
L
------
D
Y
S
V
----
S
-----
L
VKKP
Q
-----
V
T
---------
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
-------
L
D
V
V
E
R
Q
L
N
A
---
V
L
E
-----
E
-----
V
K---------
D
---
W
T
-----
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
-
D
I
H
----
A
S
I
R
----
K
--------
F
L
--------
A
--------
S
--------
K
LG
D
K
A
A
S
E
L
R
--------
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
-
P
E
F
V
D
I
I
N
S
R
N
112
HHSearch
74.82
32%
-89
- C9 -
1YYA
7
TPIS_THET8
A:
[2-249]
--
R
R
V
L
V
A
G
-
N
W
K
M
H
K
T
P
S
E
A
R
V
W
F
A
E
L
K
R
L
L
P
-
P
L
Q
S
---
E
A
--
A
V
L
P
A
F
-
P
I
L
------
P
V
A
K
E
V
LA
E
-----
T
----
Q
-----
V
G
---------
Y
G
A
Q
D
V
S
A
H
K
E
G
A
Y
T
G
E
V
S
A
R
M
L
S
D
L
G
C
R
Y
A
I
V
G
H
S
E
R
R
R
Y
H
G
E
T
D
A
L
V
A
E
K
A
K
R
L
L
E
E
G
I
T
P
I
L
C
V
G
E
P
L
E
V
R
E
K
G
---------
E
A
--
V
P
Y
T
L
R
---
Q
L
R
G
S
L
EG
V
-----
E
-----
P
-
P
--
G
---
P
E
-----
A
L
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
N
A
T
P
E
D
A
E
-
A
M
H
----
Q
A
I
R
----
K
--------
A
L
S
E
R
YG
E
A
F
A
--------
S
--------
R
--------
V
R
--------
I
L
Y
G
G
S
V
N
P
K
N
F
A
D
L
L
S
M
P
N
V
D
G
G
L
V
G
G
A
S
L
E
L
E
S
F
L
A
L
L
R
I
A
-
7
PsiBlast_PDB
72.84
31%
-92
- C9 -
3GVG
1
TPIS_MYCTU
A:
[31-276]
--------
G
-
N
W
K
M
N
L
N
H
Y
E
A
I
A
L
V
Q
K
I
A
F
S
L
P
D
K
Y
Y
D
---
R
V
D
V
A
V
I
P
P
F
-
T
D
L
R
S
V
Q
T
L
V
D
G
D
----
K
-----
L
----
R
-----
L
T
---------
Y
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
---------
N
H
V
A
H
N
I
--
E
---
Q
L
R
-----
G
S
L
AGL
L
-----
A
-
E
--
Q
---
I
G
-----
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
----
A
I
R
K
----
E
--------
L
A
--------
S
--------
L
--------
A
--------
S
P
R
I
A
D
T
V
R
-
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
A
A
I
A
-
123
HHSearch
72.83
32%
-89
- C9 -
2VXN
7
TPIS_LEIME
A:
[5-249]
--
P
Q
P
I
A
A
A
-
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
-
S
H
D
V
---
Q
C
--
V
V
A
P
T
F
-
V
H
I
------
P
L
V
Q
A
K
LR
N
-----
P
----
K
-----
Y
V
---------
I
S
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
---------
Q
T
--
A
K
V
V
L
S
---
Q
T
S
A
I
A
A
K
L
-----
T
-----
K
-
D
--
A
---
W
N
-----
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
-
E
V
H
----
L
L
L
R
----
K
--------
W
V
S
E
N
IG
T
D
V
A
--------
A
--------
K
--------
L
R
--------
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
A
T
-
102
Fugue
72.24
31%
-98
- C9 -
1IF2
1
TPIS_LEIME
A:
[3-251]
AK
P
Q
P
I
A
A
A
-
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
H
T
I
S
H
D
V
----
Q
C
--
V
V
A
P
T
F
-
V
H
I
------
P
L
V
Q
----
A
-----
K
LRNP
K
-----
Y
V
---------
I
S
A
Q
N
A
I
A
K
S
-
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
-----------
Q
T
A
K
V
V
L
S
---
Q
T
S
-----
A
-----
I
A
A
K
LT
K
-
D
--
A
---
W
N
-----
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
-
E
V
H
----
L
L
L
R
----
K
--------
W
V
--------
S
--------
E
NIG
T
D
V
A
A
K
--------
L
R
--------
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
-
P
E
F
R
D
I
I
D
A
T
R
9
PsiBlast_PDB
72.20
31%
-91
- C9 -
3TAO
2
TPIS_MYCTU
A:
[9-254]
--------
G
-
N
W
K
M
N
L
N
H
Y
E
A
I
A
L
V
Q
K
I
A
F
S
L
P
D
K
Y
Y
D
---
R
V
D
V
A
V
I
P
P
F
-
T
D
L
R
S
V
Q
T
L
V
D
G
D
----
K
-----
L
----
R
-----
L
T
---------
Y
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
---------
N
H
V
A
H
N
I
--
E
---
Q
L
R
-----
G
S
L
AGL
L
-----
A
-
E
--
Q
---
I
G
-----
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
----
A
I
R
K
----
E
--------
L
A
--------
S
--------
L
--------
A
--------
S
P
R
I
A
D
T
V
R
-
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
A
A
I
A
-
28
PsiBlast_CBE
71.83
31%
-90
- C9 -
3GVG
2
TPIS_MYCTU
B:
[31-276]
--------
G
-
N
W
K
M
N
L
N
H
Y
E
A
I
A
L
V
Q
K
I
A
F
S
L
P
D
K
Y
Y
D
---
R
V
DV
A
V
I
P
P
F
-
T
D
L
RSVQTL
V
D
G
D
----
K
-----
L
----
R
-----
L
T
---------
Y
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
---------
N
H
V
A
H
N
I
--
E
---
Q
L
R
-----
G
SLAGL
L
-----
A
-
E
--
Q
---
I
G
-----
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
----
A
I
R
K
----
E
--------
L
A
--------
S
--------
L
--------
A
--------
S
P
RIADTVR-
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
A
A
I
A
-
115
HHSearch
71.72
31%
-88
- C9 -
1O5X
2
TPIS_PLAFA
A:
[3-247]
--
R
K
Y
F
V
A
A
-
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
N
N
L
D
F
D
P
S
K
L
---
D
V
--
V
V
F
P
V
S
-
V
H
Y
------
D
H
T
R
K
L
L
-
Q
-----
S
----
K
-----
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
---------
K
T
--
I
E
V
I
T
K
---
Q
V
K
A
----
F
-----
V
DL---
I
-
D
--
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
K
D
T
CG
E
K
Q
A
--------
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
E
-
S
F
V
D
I
I
K
S
A
-
117
HHSearch
71.03
31%
-97
- C9 -
2J27
1
TPIS_TRYBB
A:
[4-249]
--
P
Q
P
I
A
A
A
-
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
T
S
I
-
N
H
D
V
---
Q
C
--
V
V
A
S
T
F
-
V
H
L
------
A
M
T
K
----
E
R
LSH-
P
----
K
-----
F
V
---------
I
A
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
---------
R
T
--
A
V
V
V
L
T
---
Q
I
A
A
I
A
K
K
L
-----
K
-----
K
-
A
--
D
---
W
A
-----
K
V
V
I
A
Y
E
A
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
-
E
A
H
----
A
L
I
R
----
S
--------
W
V
S
S
K
IG
A
D
V
A
--------
G
--------
E
--------
L
R
--------
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
K
A
T
-
59
PsiBlast_CBE
70.81
35%
-87
- C9 -
2VFH
1
TPIS_PLAFA
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
W
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F
----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
89
PsiBlast_CBE
70.48
35%
-98
- C9 -
3PSV
2
TPIS_PLAFA
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
D
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
---
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
58
PsiBlast_CBE
70.31
35%
-87
- C9 -
2VFH
1
TPIS_PLAFA
B:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
W
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
DTCGEKQA
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
77
PsiBlast_CBE
69.96
35%
-88
- C9 -
1O5X
2
TPIS_PLAFA
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F
----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
78
PsiBlast_CBE
69.49
35%
-90
- C9 -
1M7P
1
TPIS_PLAFA
B:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
DTCGEKQA
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
84
PsiBlast_CBE
69.46
35%
-85
- C9 -
1LYX
1
TPIS_PLAFA
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F
----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
39
PsiBlast_CBE
69.37
36%
-88
- C9 -
2VFE
3
TPIS_PLAFA
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F
----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
74
PsiBlast_CBE
69.24
35%
-89
- C9 -
2VFI
3
TPIS_PLAFA
B:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
DTCGEKQA
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
87
PsiBlast_CBE
69.01
35%
-91
- C9 -
3PSW
3
TPIS_PLAFA
B:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
Q
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
DTCGEKQA
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
81
PsiBlast_CBE
68.97
35%
-90
- C9 -
1M7O
1
TPIS_PLAFA
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F
----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
88
PsiBlast_CBE
68.67
35%
-89
- C9 -
3PSW
3
TPIS_PLAFA
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
Q
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
93
PsiBlast_CBE
68.34
35%
-95
- C9 -
4ZZ9
4
?
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
S
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
---
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
82
PsiBlast_CBE
68.14
35%
-88
- C9 -
1LZO
1
TPIS_PLAFA
D:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
DTCGEKQA
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
92
PsiBlast_CBE
68.11
35%
-90
* C9 *
4ZZ9
3
?
B:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
S
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
76
PsiBlast_CBE
68.08
35%
-86
- C9 -
1O5X
1
TPIS_PLAFA
B:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
DTCGEKQA
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
38
PsiBlast_CBE
68.06
36%
-89
- C9 -
2VFE
3
TPIS_PLAFA
B:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
79
PsiBlast_CBE
68.05
35%
-91
- C9 -
1M7P
1
TPIS_PLAFA
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F
----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
32
PsiBlast_CBE
67.98
37%
-79
- C9 -
7TIM
1
TPIS_YEAST
B:
[57-238]
--------------------------------------------------------------------------------
Q
-----
V
T
---------
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
KT-------
L
D
V
V
E
R
Q
L
N
A
---
V
L
E
-----
E
-----
V
-----
K
----
D
---
W
T
-----
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
-
D
I
H
----
A
S
I
R
----
K
--------
F
L
--------
A
--------
S
--------
K
--------
L
G
DKAASELR
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
12
PsiBlast_PDB
67.77
35%
-88
- C9 -
4MVA
2
?
A:
[82-270]
--------------------------------------------------------------------------------
H
-----
I
M
---------
L
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
-----------
K
T
E
E
V
C
A
R
---
Q
I
D
-----
A
-----
V
L
K
T
QG
A
-
A
--
A
---
F
E
-----
G
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
-
A
V
H
----
K
F
I
R
----
D
H
I
A
K
V
D
A
-
N
I
--------
A
--------
E
--------
Q
--------
V
I
--------
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
A
-
75
PsiBlast_CBE
67.49
35%
-84
- C9 -
2VFI
3
TPIS_PLAFA
A:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F
----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
D
T
CG
E
K
Q
A
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
31
PsiBlast_CBE
67.18
35%
-89
- C9 -
4MVA
2
?
B:
[82-270]
--------------------------------------------------------------------------------
H
-----
I
M
---------
L
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
-----------
K
T
E
E
V
C
A
R
---
Q
I
D
-----
A
-----
V
LKTQG
A
-
A
--
A
---
F
E
-----
G
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
-
A
V
H
----
K
F
I
R
----
D
HIAKVDA-
N
I
--------
A
--------
E
--------
Q
--------
V
I
--------
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
A
-
83
PsiBlast_CBE
67.10
35%
-92
- C9 -
1LZO
1
TPIS_PLAFA
B:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
DTCGEKQA
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
49
PsiBlast_CBE
67.05
36%
-82
- C9 -
4FF7
7
TPIS_YEAST
B:
[58-239]
--------------------------------------------------------------------------------
Q
-----
V
T
---------
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
KT-------
L
D
V
V
E
R
Q
L
N
A
---
V
L
E
-----
E
-----
V
-----
K
----
D
---
W
T
-----
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
-
D
I
H
----
A
S
I
R
----
K
--------
F
L
--------
A
--------
S
--------
K
--------
L
G
DKAASELR
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
50
PsiBlast_CBE
66.97
36%
-81
- C9 -
4FF7
8
TPIS_YEAST
A:
[58-239]
--------------------------------------------------------------------------------
Q
-----
V
T
---------
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
K
T
-------
L
D
V
V
E
R
Q
L
N
A
---
V
L
E
-----
E
-----
V
-----
K
----
D
---
W
T
-----
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
-
D
I
H
----
A
S
I
R
----
K
--------
F
L
--------
A
--------
S
--------
K
--------
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
80
PsiBlast_CBE
66.65
35%
-84
- C9 -
1M7O
1
TPIS_PLAFA
B:
[59-244]
--------------------------------------------------------------------------------------
F
S
---------
T
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
-----------
K
T
I
E
V
I
T
K
---
Q
V
K
-----
A
F----
V
-----
D
-
L
ID
N
---
F
D
-----
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
-
L
V
H
----
K
E
I
R
----
K
--------
I
V
--------
K
DTCGEKQA
N
--------
Q
--------
I
R
--------
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
-
42
PsiBlast_CBE
66.31
36%
-87
- C9 -
3YPI
1
TPIS_YEAST
A:
[57-238]
--------------------------------------------------------------------------------
Q
-----
V
T
---------
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
-------
L
D
V
V
E
R
Q
L
N
A
---
V
L
E
-----
E
-----
V
-----
K
----
D
---
W
T
-----
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
-
D
I
H
----
A
S
I
R
----
K
--------
F
L
--------
A
--------
S
--------
K
--------
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
16
PsiBlast_PDB
65.93
37%
-74
- C9 -
7TIM
1
TPIS_YEAST
A:
[57-238]
--------------------------------------------------------------------------------
Q
-----
V
T
---------
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
-------
L
D
V
V
E
R
Q
L
N
A
---
V
L
E
-----
E
-----
V
-----
K
----
D
---
W
T
-----
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
-
D
I
H
----
A
S
I
R
----
K
--------
F
L
--------
A
--------
S
--------
K
--------
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
15
PsiBlast_PDB
65.77
37%
-78
- C9 -
2YPI
1
TPIS_YEAST
A:
[57-238]
--------------------------------------------------------------------------------
Q
-----
V
T
---------
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
-------
L
D
V
V
E
R
Q
L
N
A
---
V
L
E
-----
E
-----
V
-----
K
----
D
---
W
T
-----
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
-
D
I
H
----
A
S
I
R
----
K
--------
F
L
--------
A
--------
S
--------
K
--------
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
41
PsiBlast_CBE
65.05
36%
-83
- C9 -
3YPI
1
TPIS_YEAST
B:
[57-238]
--------------------------------------------------------------------------------
Q
-----
V
T
---------
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
KT-------
L
D
V
V
E
R
Q
L
N
A
---
V
L
E
-----
E
-----
V
-----
K
----
D
---
W
T
-----
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
-
D
I
H
----
A
S
I
R
----
K
--------
F
L
--------
A
--------
S
--------
K
--------
L
G
DKAASELR
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
33
PsiBlast_CBE
62.57
37%
-77
- C9 -
2YPI
1
TPIS_YEAST
B:
[57-238]
--------------------------------------------------------------------------------
Q
-----
V
T
---------
V
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
KT-------
L
D
V
V
E
R
Q
L
N
A
---
V
L
E
-----
E
-----
V
-----
K
----
D
---
W
T
-----
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
-
D
I
H
----
A
S
I
R
----
K
--------
F
L
--------
A
--------
S
--------
K
--------
L
G
DKAASELR
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
90
PsiBlast_CBE
62.15
35%
-74
- C9 -
1SW3
1
TPIS_CHICK
B:
[44-239]
--------------------------------------------------------------
P
S
I
----
Y
-----
L
----
D
-----
F
A
RQKLDAKIG
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
---------
I
--
T
E
K
V
V
F
E
---
Q
T
K
-----
A
-----
I
-----
A
-
D
--
N
VKD
W
S
-----
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
-
E
V
H
EKLR
G
W
L
K
SHVS
D
--------
A
V
--------
A
--------
Q
--------
S
--------
T
R
--------
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
-
91
PsiBlast_CBE
60.83
35%
-76
- C9 -
1SW3
1
TPIS_CHICK
A:
[44-239]
--------------------------------------------------------------
P
S
I
----
Y
-----
L
----
D
-----
F
A
R
Q
K
LDAK
I
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
---------
I
--
T
E
K
V
V
F
E
---
Q
T
K
-----
A
-----
I
-----
A
-
D
--
N
VKD
W
S
-----
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
-
E
V
H
E
K
L
R
G
W
L
K
S
HVS
D
--------
A
V
--------
A
--------
Q
--------
S
--------
T
R
--------
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
A
K
H
-