@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0181: (2015-12-13 )
MGFLKGKKGLIVGVANNKSIAYGIAQSCFNQGATLAFTYLNESLEKRVRPIAQELNSPYVYELDVSKEEHFKSLYNNIKQDLGSLDFIVHSVAFAPKEALEGSLLETSKSAFNTAMEISVYSLIELTNTLKPLLNNGASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAVDLGKHNIRVNALSAGPIRTLASSGIADFRMILKWNEINAPLRKNVSLEEVGNAGMYLLSSLSNGVSGEVHFVDAGYHVMGMGAVEEKDNKATLLWDLHKEQ
Atome Classification :
(70 SA)
.........10........20........30.........40........50....--..--..60-----------........70........80...-.....90........100....-.---..110.......120.......130..--.-.---...140.......150...--....160.......170......-.180.......190.......200.......210......---.220.......230.-......240.......250-........260.......270...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGFLKGK
K
G
L
I
V
G
VANNK
S
I
A
Y
G
I
A
Q
S
C
FN-QG
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
EL--NS--
P
Y
V
Y
-----------
E
LDV
S
K
E
E
H
F
K
S
L
Y
N
N
I
K
Q
D
L
G
S
-
L
D
F
I
V
H
S
V
AFA
P
K
E
A
LE
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--N-N---G
A
S
V
L
T
L
S
YLGST
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
DLGK-H
N
I
R
V
N
ALSAG
P
I
R
T
L
A
SSG
I
A
D
F
R
M
I
L
K
WNEINA
P
L
RKN---V
S
L
E
E
VG
N
A
G
M
Y
L
L
S
-
S
L
SNGVSG
E
V
H
F
V
DAG
Y
H
--
V
M
GMGAVEEKDN
K
A
T
L
L
W
D
LHKEQ
22
PsiBlast_CBE
95.81
98%
-119
- C1 -
2PD4
2
FABI_HELPY
C:
[2-275]
-
G
F
L
K
G
K
K
G
L
I
V
G
V
A
N
N
K
S
I
A
Y
G
I
A
Q
S
C
F
N
-
Q
G
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
E
L
--
N
S
--
P
Y
V
Y
-----------
E
L
D
V
S
K
E
E
H
F
K
S
L
Y
N
S
V
K
K
D
L
G
S
-
L
D
F
I
V
H
S
V
A
F
A
P
K
E
A
L
E
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--
N
-
N
---
G
A
S
V
L
T
L
S
Y
L
G
S
T
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
D
L
G
K
-
H
H
I
R
V
N
A
L
S
A
G
P
I
R
T
L
A
S
S
G
I
A
D
F
R
M
I
L
K
W
N
E
I
N
A
P
L
R
K
N
---
V
S
L
E
E
V
G
N
A
G
M
Y
L
L
S
-
S
L
S
S
G
V
S
G
E
V
H
F
V
D
A
G
Y
H
--
V
M
G
M
G
A
V
E
E
K
D
N
K
A
T
L
L
W
D
L
H
K
E
Q
21
PsiBlast_CBE
95.68
98%
-120
- C1 -
2PD4
2
FABI_HELPY
D:
[2-275]
-
G
F
L
K
G
K
K
G
L
I
V
G
V
A
N
N
K
S
I
A
Y
G
I
A
Q
S
C
F
N
-
Q
G
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
E
L
--
N
S
--
P
Y
V
Y
-----------
E
L
D
V
S
K
E
E
H
F
K
S
L
Y
N
S
V
K
K
D
L
G
S
-
L
D
F
I
V
H
S
V
A
F
A
P
K
E
A
L
E
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--
N
-
N
---
G
A
S
V
L
T
L
S
Y
L
G
S
T
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
D
L
G
K
-
H
H
I
R
V
N
A
L
S
A
G
P
I
R
T
L
A
S
S
G
I
A
D
F
R
M
I
L
K
W
N
E
I
N
A
P
L
R
K
N
---
V
S
L
E
E
V
G
N
A
G
M
Y
L
L
S
-
S
L
S
S
G
V
S
G
E
V
H
F
V
D
A
G
Y
H
--
V
M
G
M
G
A
V
E
E
K
D
N
K
A
T
L
L
W
D
L
H
K
E
Q
23
PsiBlast_CBE
95.59
98%
-121
- C1 -
2PD4
2
FABI_HELPY
B:
[2-275]
-
G
F
L
K
G
K
K
G
L
I
V
G
V
A
N
N
K
S
I
A
Y
G
I
A
Q
S
C
F
N
-
Q
G
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
E
L
--
N
S
--
P
Y
V
Y
-----------
E
L
D
V
S
K
E
E
H
F
K
S
L
Y
N
S
V
K
K
D
L
G
S
-
L
D
F
I
V
H
S
V
A
F
A
P
K
E
A
L
E
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--
N
-
N
---
G
A
S
V
L
T
L
S
Y
L
G
S
T
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
D
L
G
K
-
H
H
I
R
V
N
A
L
S
A
G
P
I
R
T
L
A
S
S
G
I
A
D
F
R
M
I
L
K
W
N
E
I
N
A
P
L
R
K
N
---
V
S
L
E
E
V
G
N
A
G
M
Y
L
L
S
-
S
L
S
S
G
V
S
G
E
V
H
F
V
D
A
G
Y
H
--
V
M
G
M
G
A
V
E
E
K
D
N
K
A
T
L
L
W
D
L
H
K
E
Q
1
PsiBlast_PDB
95.48
98%
-118
- C1 -
2PD3
2
FABI_HELPY
A:
[2-275]
-
G
F
L
K
G
K
K
G
L
I
V
G
V
A
N
N
K
S
I
A
Y
G
I
A
Q
S
C
F
N
-
Q
G
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
E
L
--
N
S
--
P
Y
V
Y
-----------
E
L
D
V
S
K
E
E
H
F
K
S
L
Y
N
S
V
K
K
D
L
G
S
-
L
D
F
I
V
H
S
V
A
F
A
P
K
E
A
L
E
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--
N
-
N
---
G
A
S
V
L
T
L
S
Y
L
G
S
T
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
D
L
G
K
-
H
H
I
R
V
N
A
L
S
A
G
P
I
R
T
L
A
S
S
G
I
A
D
F
R
M
I
L
K
W
N
E
I
N
A
P
L
R
K
N
---
V
S
L
E
E
V
G
N
A
G
M
Y
L
L
S
-
S
L
S
S
G
V
S
G
E
V
H
F
V
D
A
G
Y
H
--
V
M
G
M
G
A
V
E
E
K
D
N
K
A
T
L
L
W
D
L
H
K
E
Q
111
HHSearch
95.18
98%
-118
- C1 -
2PD4
2
FABI_HELPY
A:
[2-275]
-
G
F
L
K
G
K
K
G
L
I
V
G
V
A
N
N
K
S
I
A
Y
G
I
A
Q
S
C
F
N
-
Q
G
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
E
L
--
N
S
--
P
Y
V
Y
-----------
E
L
D
V
S
K
E
E
H
F
K
S
L
Y
N
S
V
K
K
D
L
G
S
-
L
D
F
I
V
H
S
V
A
F
A
P
K
E
A
L
E
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--
N
-
N
---
G
A
S
V
L
T
L
S
Y
L
G
S
T
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
D
L
G
K
-
H
H
I
R
V
N
A
L
S
A
G
P
I
R
T
L
A
S
S
G
I
A
D
F
R
M
I
L
K
W
N
E
I
N
A
P
L
R
K
N
---
V
S
L
E
E
V
G
N
A
G
M
Y
L
L
S
-
S
L
S
S
G
V
S
G
E
V
H
F
V
D
A
G
Y
H
--
V
M
G
M
G
A
V
E
E
K
D
N
K
A
T
L
L
W
D
L
H
K
E
Q
2
PsiBlast_PDB
95.18
98%
-118
- C1 -
2PD4
2
FABI_HELPY
A:
[2-275]
-
G
F
L
K
G
K
K
G
L
I
V
G
V
A
N
N
K
S
I
A
Y
G
I
A
Q
S
C
F
N
-
Q
G
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
E
L
--
N
S
--
P
Y
V
Y
-----------
E
L
D
V
S
K
E
E
H
F
K
S
L
Y
N
S
V
K
K
D
L
G
S
-
L
D
F
I
V
H
S
V
A
F
A
P
K
E
A
L
E
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--
N
-
N
---
G
A
S
V
L
T
L
S
Y
L
G
S
T
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
D
L
G
K
-
H
H
I
R
V
N
A
L
S
A
G
P
I
R
T
L
A
S
S
G
I
A
D
F
R
M
I
L
K
W
N
E
I
N
A
P
L
R
K
N
---
V
S
L
E
E
V
G
N
A
G
M
Y
L
L
S
-
S
L
S
S
G
V
S
G
E
V
H
F
V
D
A
G
Y
H
--
V
M
G
M
G
A
V
E
E
K
D
N
K
A
T
L
L
W
D
L
H
K
E
Q
24
PsiBlast_CBE
95.14
98%
-117
- C1 -
2PD3
2
FABI_HELPY
D:
[2-275]
-
G
F
L
K
G
K
K
G
L
I
V
G
V
A
N
N
K
S
I
A
Y
G
I
A
Q
S
C
F
N
-
Q
G
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
E
L
--
N
S
--
P
Y
V
Y
-----------
E
L
D
V
S
K
E
E
H
F
K
S
L
Y
N
S
V
K
K
D
L
G
S
-
L
D
F
I
V
H
S
V
A
F
A
P
K
E
A
L
E
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--
N
-
N
---
G
A
S
V
L
T
L
S
Y
L
G
S
T
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
D
L
G
K
-
H
H
I
R
V
N
A
L
S
A
G
P
I
R
T
L
A
S
S
G
I
A
D
F
R
M
I
L
K
W
N
E
I
N
A
P
L
R
K
N
---
V
S
L
E
E
V
G
N
A
G
M
Y
L
L
S
-
S
L
S
S
G
V
S
G
E
V
H
F
V
D
A
G
Y
H
--
V
M
G
M
G
A
V
E
E
K
D
N
K
A
T
L
L
W
D
L
H
K
E
Q
25
PsiBlast_CBE
94.99
98%
-118
- C1 -
2PD3
2
FABI_HELPY
C:
[2-275]
-
G
F
L
K
G
K
K
G
L
I
V
G
V
A
N
N
K
S
I
A
Y
G
I
A
Q
S
C
F
N
-
Q
G
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
E
L
--
N
S
--
P
Y
V
Y
-----------
E
L
D
V
S
K
E
E
H
F
K
S
L
Y
N
S
V
K
K
D
L
G
S
-
L
D
F
I
V
H
S
V
A
F
A
P
K
E
A
L
E
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--
N
-
N
---
G
A
S
V
L
T
L
S
Y
L
G
S
T
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
D
L
G
K
-
H
H
I
R
V
N
A
L
S
A
G
P
I
R
T
L
A
S
S
G
I
A
D
F
R
M
I
L
K
W
N
E
I
N
A
P
L
R
K
N
---
V
S
L
E
E
V
G
N
A
G
M
Y
L
L
S
-
S
L
S
S
G
V
S
G
E
V
H
F
V
D
A
G
Y
H
--
V
M
G
M
G
A
V
E
E
K
D
N
K
A
T
L
L
W
D
L
H
K
E
Q
26
PsiBlast_CBE
93.47
98%
-116
- C1 -
2PD3
2
FABI_HELPY
B:
[2-275]
-
G
F
L
K
G
K
K
G
L
I
V
G
V
A
N
N
K
S
I
A
Y
G
I
A
Q
S
C
F
N
-
Q
G
A
T
L
A
F
T
Y
L
N
E
S
L
E
K
R
V
R
P
I
A
Q
E
L
--
N
S
--
P
Y
V
Y
-----------
E
L
D
V
S
K
E
E
H
F
K
S
L
Y
N
S
V
K
K
D
L
G
S
-
L
D
F
I
V
H
S
V
A
F
A
P
K
E
A
L
E
G
S
L
L
E
-
T
---
S
K
S
A
F
N
T
A
M
E
I
S
V
Y
S
L
I
E
L
T
N
T
L
K
P
L
L
--
N
-
N
---
G
A
S
V
L
T
L
S
Y
L
G
S
T
K
Y
M
A
H
Y
--
N
V
M
G
L
A
K
A
A
L
E
S
A
V
R
Y
L
A
V
D
L
G
K
-
H
H
I
R
V
N
A
L
S
A
G
P
I
R
T
L
A
S
S
G
I
A
D
F
R
M
I
L
K
W
N
E
I
N
A
P
L
R
K
N
---
V
S
L
E
E
V
G
N
A
G
M
Y
L
L
S
-
S
L
S
S
G
V
S
G
E
V
H
F
V
D
A
G
Y
H
--
V
M
G
M
G
A
V
E
E
K
D
N
K
A
T
L
L
W
D
L
H
K
E
Q
4
PsiBlast_PDB
82.60
52%
-119
- C1 -
3K2E
6
?
A:
[27-282]
--
L
M
E
G
K
K
G
V
I
I
G
V
A
N
D
K
S
L
A
W
G
I
A
K
A
V
C
A
-
Q
G
A
E
V
A
L
T
Y
L
S
E
T
F
K
K
R
V
D
P
L
A
E
S
L
--
G
V
--
K
L
T
V
-----------
P
C
D
V
S
D
A
E
S
V
D
N
M
F
K
V
L
A
E
E
W
G
S
-
L
D
F
V
V
H
A
V
A
F
S
D
K
N
E
L
K
G
R
Y
V
D
-
T
---
S
L
G
N
F
L
T
S
M
H
I
S
C
Y
S
F
T
Y
I
A
S
K
A
E
P
L
M
--
T
-
N
---
G
G
S
I
L
T
L
S
Y
Y
G
A
E
K
V
V
P
H
Y
--
N
V
M
G
V
C
K
A
A
L
E
A
S
V
K
Y
L
A
V
D
L
G
K
-
Q
Q
I
R
V
N
A
I
S
A
G
P
V
R
T
L
A
S
S
G
I
S
D
F
H
Y
I
L
T
W
N
K
Y
N
S
P
L
R
R
N
---
T
T
L
D
D
V
G
G
A
A
L
Y
L
L
S
-
D
L
G
R
G
T
T
G
E
T
V
H
V
D
C
G
Y
H
--
V
V
G
M
K
S
V
-----------------
5
PsiBlast_PDB
82.11
52%
-122
- C1 -
3K31
5
?
A:
[27-282]
--
L
M
E
G
K
K
G
V
I
I
G
V
A
N
D
K
S
L
A
W
G
I
A
K
A
V
C
A
-
Q
G
A
E
V
A
L
T
Y
L
S
E
T
F
K
K
R
V
D
P
L
A
E
S
L
--
G
V
--
K
L
T
V
-----------
P
C
D
V
S
D
A
E
S
V
D
N
M
F
K
V
L
A
E
E
W
G
S
-
L
D
F
V
V
H
A
V
A
F
S
D
K
N
E
L
K
G
R
Y
V
D
-
T
---
S
L
G
N
F
L
T
S
M
H
I
S
C
Y
S
F
T
Y
I
A
S
K
A
E
P
L
M
--
T
-
N
---
G
G
S
I
L
T
L
S
Y
Y
G
A
E
K
V
V
P
H
Y
--
N
V
M
G
V
C
K
A
A
L
E
A
S
V
K
Y
L
A
V
D
L
G
K
-
Q
Q
I
R
V
N
A
I
S
A
G
P
V
R
T
L
A
S
S
G
I
S
D
F
H
Y
I
L
T
W
N
K
Y
N
S
P
L
R
R
N
---
T
T
L
D
D
V
G
G
A
A
L
Y
L
L
S
-
D
L
G
R
G
T
T
G
E
T
V
H
V
D
C
G
Y
H
--
V
V
G
M
K
S
V
-----------------
3
PsiBlast_PDB
80.87
53%
-118
- C1 -
3GRK
-
?
A:
[6-259]
-
G
L
L
Q
G
K
R
G
L
I
L
G
V
A
N
N
R
S
I
A
W
G
I
A
K
A
A
R
E
-
A
G
A
E
L
A
F
T
Y
Q
G
D
A
L
K
K
R
V
E
P
L
A
E
E
L
--
G
A
--
F
V
A
G
-----------
H
C
D
V
A
D
A
A
S
I
D
A
V
F
E
T
L
E
K
K
W
G
K
-
L
D
F
L
V
H
A
I
G
F
S
D
K
D
E
L
T
G
R
Y
I
D
-
T
---
S
E
A
N
F
T
N
T
M
L
I
S
V
Y
S
L
T
A
V
S
R
R
A
E
K
L
M
--
A
-
D
---
G
G
S
I
L
T
L
T
Y
Y
G
A
E
K
V
M
P
N
Y
--
N
V
M
G
V
A
K
A
A
L
E
A
S
V
K
Y
L
A
V
D
L
G
P
-
Q
N
I
R
V
N
A
I
S
A
G
P
I
K
T
------
G
D
F
R
Y
I
L
K
W
N
E
Y
N
A
P
L
R
R
T
---
V
T
I
D
E
V
G
D
V
G
L
Y
F
L
S
-
D
L
S
R
S
V
T
G
E
V
H
H
A
D
S
G
Y
H
--
V
I
G
M
--------------------
28
PsiBlast_CBE
80.55
52%
-115
- C1 -
3K2E
6
?
B:
[27-286]
--
L
M
E
G
K
K
G
V
I
I
G
V
A
N
D
K
S
L
A
W
G
I
A
K
A
V
C
A
-
Q
G
A
E
V
A
L
T
Y
L
S
E
T
F
K
K
R
V
D
P
L
A
E
S
L
--
G
V
--
K
L
T
V
-----------
P
C
D
V
S
D
A
E
S
V
D
N
M
F
K
V
L
A
E
E
W
G
S
-
L
D
F
V
V
H
A
V
A
F
S
D
K
N
E
L
K
G
R
Y
V
D
-
T
---
S
L
G
N
F
L
T
S
M
H
I
S
C
Y
S
F
T
Y
I
A
S
K
A
E
P
L
M
--
T
-
N
---
G
G
S
I
L
T
L
S
Y
Y
G
A
E
K
V
V
P
H
Y
--
N
V
M
G
V
C
K
A
A
L
E
A
S
V
K
Y
L
A
V
D
L
G
K
-
Q
Q
I
R
V
N
A
I
S
A
G
P
V
R
-------
S
D
F
H
Y
I
L
T
W
N
K
Y
N
S
P
L
R
R
N
---
T
T
L
D
D
V
G
G
A
A
L
Y
L
L
S
-
D
L
G
R
G
T
T
G
E
T
V
H
V
D
C
G
Y
H
--
V
V
G
M
K
S
V
D
A
P
D
I
------------
27
PsiBlast_CBE
80.48
52%
-115
- C1 -
3K31
3
?
B:
[27-286]
--
L
M
E
G
K
K
G
V
I
I
G
V
A
N
D
K
S
L
A
W
G
I
A
K
A
V
C
A
-
Q
G
A
E
V
A
L
T
Y
L
S
E
T
F
K
K
R
V
D
P
L
A
E
S
L
--
G
V
--
K
L
T
V
-----------
P
C
D
V
S
D
A
E
S
V
D
N
M
F
K
V
L
A
E
E
W
G
S
-
L
D
F
V
V
H
A
V
A
F
S
D
K
N
E
L
K
G
R
Y
V
D
-
T
---
S
L
G
N
F
L
T
S
M
H
I
S
C
Y
S
F
T
Y
I
A
S
K
A
E
P
L
M
--
T
-
N
---
G
G
S
I
L
T
L
S
Y
Y
G
A
E
K
V
V
P
H
Y
--
N
V
M
G
V
C
K
A
A
L
E
A
S
V
K
Y
L
A
V
D
L
G
K
-
Q
Q
I
R
V
N
A
I
S
A
G
P
V
R
-------
S
D
F
H
Y
I
L
T
W
N
K
Y
N
S
P
L
R
R
N
---
T
T
L
D
D
V
G
G
A
A
L
Y
L
L
S
-
D
L
G
R
G
T
T
G
E
T
V
H
V
D
C
G
Y
H
--
V
V
G
M
K
S
V
D
A
P
D
I
------------
29
PsiBlast_CBE
79.61
49%
-117
- C1 -
4M89
2
?
B:
[2-254]
-
G
F
L
Q
G
K
K
I
L
I
T
G
M
I
S
E
R
S
I
A
Y
G
I
A
K
A
C
R
E
-
Q
G
A
E
L
A
F
T
Y
V
V
D
K
L
E
E
R
V
R
K
M
A
A
E
L
--
D
S
--
E
L
V
F
-----------
R
C
D
V
A
S
D
D
E
I
N
Q
V
F
A
D
L
G
K
H
W
D
G
-
L
D
G
L
V
H
S
I
G
F
A
P
K
E
A
L
S
G
D
F
L
D
-
S
I--
S
R
E
A
F
N
T
A
H
E
I
S
A
Y
S
L
P
A
L
A
K
A
A
R
P
M
M
--
R
G
R
---
N
S
A
I
V
A
L
S
Y
L
G
A
V
R
A
I
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
I
R
F
T
A
A
C
L
G
K
-
E
G
I
R
C
N
G
I
S
A
G
P
I
K
T
L
A
A
S
G
I
A
D
F
G
K
L
L
G
H
V
A
A
H
N
P
L
R
R
N
---
V
T
I
E
E
V
G
N
T
A
A
F
L
L
S
-
D
L
S
S
G
I
T
G
E
I
T
Y
V
D
G
G
Y
S
--
I
N
A
L
S
-------------------
63
PsiBlast_CBE
79.53
46%
-119
- C1 -
3PJD
2
FABI_ECOLI
A:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
A
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
40
PsiBlast_CBE
79.45
44%
-118
- C1 -
2WYV
1
?
D:
[6-257]
---
L
S
G
K
K
A
L
V
M
G
V
T
N
Q
R
S
L
G
F
A
I
A
A
K
L
K
E
-
A
G
A
E
V
A
L
S
Y
Q
A
E
R
L
R
P
E
A
E
K
L
A
E
A
L
--
G
G
--
A
L
L
F
-----------
R
A
D
V
T
Q
D
E
E
L
D
A
L
F
A
G
V
K
E
A
F
G
G
-
L
D
Y
L
V
H
A
I
A
F
A
P
R
E
A
M
E
G
R
Y
I
D
-
T
---
R
R
Q
D
W
L
L
A
L
E
V
S
A
Y
S
L
V
A
V
A
R
R
A
E
P
L
L
--
R
-
E
---
G
G
G
I
V
T
L
T
Y
Y
A
S
E
K
V
V
P
K
Y
--
N
V
M
A
I
A
K
A
A
L
E
A
S
V
R
Y
L
A
Y
E
L
G
P
-
K
G
V
R
V
N
A
I
S
A
G
P
V
R
T
V
A
A
R
S
I
P
G
F
T
K
M
Y
D
R
V
A
Q
T
A
P
L
R
R
N
---
I
T
Q
E
E
V
G
N
L
G
L
F
L
L
S
-
P
L
A
S
G
I
T
G
E
V
V
Y
V
D
A
G
Y
H
--
I
M
G
M
--------------------
8
PsiBlast_PDB
79.43
49%
-117
- C1 -
4M89
2
?
A:
[2-254]
-
G
F
L
Q
G
K
K
I
L
I
T
G
M
I
S
E
R
S
I
A
Y
G
I
A
K
A
C
R
E
-
Q
G
A
E
L
A
F
T
Y
V
V
D
K
L
E
E
R
V
R
K
M
A
A
E
L
--
D
S
--
E
L
V
F
-----------
R
C
D
V
A
S
D
D
E
I
N
Q
V
F
A
D
L
G
K
H
W
D
G
-
L
D
G
L
V
H
S
I
G
F
A
P
K
E
A
L
S
G
D
F
L
D
-
S
I--
S
R
E
A
F
N
T
A
H
E
I
S
A
Y
S
L
P
A
L
A
K
A
A
R
P
M
M
--
R
G
R
---
N
S
A
I
V
A
L
S
Y
L
G
A
V
R
A
I
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
I
R
F
T
A
A
C
L
G
K
-
E
G
I
R
C
N
G
I
S
A
G
P
I
K
T
L
A
A
S
G
I
A
D
F
G
K
L
L
G
H
V
A
A
H
N
P
L
R
R
N
---
V
T
I
E
E
V
G
N
T
A
A
F
L
L
S
-
D
L
S
S
G
I
T
G
E
I
T
Y
V
D
G
G
Y
S
--
I
N
A
L
S
-------------------
58
PsiBlast_CBE
79.42
47%
-117
- C1 -
4NR0
2
FABI_PSEAE
D:
[2-262]
-
G
F
L
T
G
K
R
A
L
I
V
G
V
A
S
K
L
S
I
A
S
G
I
A
A
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
R
G
R
V
E
E
F
A
S
G
W
--
G
S
RP
E
L
C
F
-----------
P
C
D
V
A
D
D
S
Q
I
E
A
V
F
A
A
L
G
K
H
W
D
G
-
L
D
I
I
V
H
S
V
G
F
A
P
G
D
Q
L
D
G
D
F
T
A
V
T
---
T
R
E
G
F
R
I
A
H
D
I
S
A
Y
S
F
I
A
L
A
K
A
G
R
E
M
M
KG
R
-
N
---
G
-
S
L
L
T
L
S
Y
L
G
A
E
R
T
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
G
S
L
G
A
-
E
G
T
R
V
N
A
V
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
A
A
N
E
R
Q
T
P
L
R
R
N
---
V
T
I
E
E
V
G
N
A
G
A
F
L
C
S
-
D
L
A
S
G
I
S
G
E
I
L
Y
V
D
G
G
F
N
--
T
T
A
M
G
P
L
-----------------
30
PsiBlast_CBE
79.26
49%
-122
- C1 -
4M87
1
?
B:
[2-254]
-
G
F
L
Q
G
K
K
I
L
I
T
G
M
I
S
E
R
S
I
A
Y
G
I
A
K
A
C
R
E
-
Q
G
A
E
L
A
F
T
Y
V
V
D
K
L
E
E
R
V
R
K
M
A
A
E
L
--
D
S
--
E
L
V
F
-----------
R
C
D
V
A
S
D
D
E
I
N
Q
V
F
A
D
L
G
K
H
W
D
G
-
L
D
G
L
V
H
S
I
G
F
A
P
K
E
A
L
S
G
D
F
L
D
-
S
I--
S
R
E
A
F
N
T
A
H
E
I
S
A
Y
S
L
P
A
L
A
K
A
A
R
P
M
M
--
R
G
R
---
N
S
A
I
V
A
L
S
Y
L
G
A
V
R
A
I
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
I
R
F
T
A
A
C
L
G
K
-
E
G
I
R
C
N
G
I
S
A
G
P
I
-----------
G
K
L
L
G
H
V
A
A
H
N
P
L
R
R
N
---
V
T
I
E
E
V
G
N
T
A
A
F
L
L
S
-
D
L
S
S
G
I
T
G
E
I
T
Y
V
D
G
G
Y
S
--
I
N
A
L
S
-------------------
9
PsiBlast_PDB
79.13
49%
-119
- C1 -
4M87
1
?
A:
[2-254]
-
G
F
L
Q
G
K
K
I
L
I
T
G
M
I
S
E
R
S
I
A
Y
G
I
A
K
A
C
R
E
-
Q
G
A
E
L
A
F
T
Y
V
V
D
K
L
E
E
R
V
R
K
M
A
A
E
L
--
D
S
--
E
L
V
F
-----------
R
C
D
V
A
S
D
D
E
I
N
Q
V
F
A
D
L
G
K
H
W
D
G
-
L
D
G
L
V
H
S
I
G
F
A
P
K
E
A
L
S
G
D
F
L
D
-
S
I--
S
R
E
A
F
N
T
A
H
E
I
S
A
Y
S
L
P
A
L
A
K
A
A
R
P
M
M
--
R
G
R
---
N
S
A
I
V
A
L
S
Y
L
G
A
V
R
A
I
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
I
R
F
T
A
A
C
L
G
K
-
E
G
I
R
C
N
G
I
S
A
G
P
I
K
T
L
A
A
S
G
I
A
D
F
G
K
L
L
G
H
V
A
A
H
N
P
L
R
R
N
---
V
T
I
E
E
V
G
N
T
A
A
F
L
L
S
-
D
L
S
S
G
I
T
G
E
I
T
Y
V
D
G
G
Y
S
--
I
N
A
L
S
-------------------
99
PsiBlast_CBE
79.08
45%
-118
- C1 -
1QG6
2
FABI_ECOLI
A:
[1-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
97
PsiBlast_CBE
79.05
45%
-118
- C1 -
1QG6
2
FABI_ECOLI
C:
[1-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
62
PsiBlast_CBE
78.86
46%
-119
- C1 -
3PJD
2
FABI_ECOLI
B:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
A
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
59
PsiBlast_CBE
78.78
47%
-115
- C1 -
4NR0
2
FABI_PSEAE
C:
[2-262]
-
G
F
L
T
G
K
R
A
L
I
V
G
V
A
S
K
L
S
I
A
S
G
I
A
A
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
R
G
R
V
E
E
F
A
S
G
W
--
G
S
RP
E
L
C
F
-----------
P
C
D
V
A
D
D
S
Q
I
E
A
V
F
A
A
L
G
K
H
W
D
G
-
L
D
I
I
V
H
S
V
G
F
A
P
G
D
Q
L
D
G
D
F
T
A
V
T
---
T
R
E
G
F
R
I
A
H
D
I
S
A
Y
S
F
I
A
L
A
K
A
G
R
E
M
M
KG
R
-
N
---
G
-
S
L
L
T
L
S
Y
L
G
A
E
R
T
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
G
S
L
G
A
-
E
G
T
R
V
N
A
V
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
A
A
N
E
R
Q
T
P
L
R
R
N
---
V
T
I
E
E
V
G
N
A
G
A
F
L
C
S
-
D
L
A
S
G
I
S
G
E
I
L
Y
V
D
G
G
F
N
--
T
T
A
M
G
P
L
-----------------
98
PsiBlast_CBE
78.69
45%
-118
- C1 -
1QG6
2
FABI_ECOLI
B:
[1-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
61
PsiBlast_CBE
78.49
47%
-114
- C1 -
4NR0
2
FABI_PSEAE
A:
[2-260]
-
G
F
L
T
G
K
R
A
L
I
V
G
V
A
S
K
L
S
I
A
S
G
I
A
A
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
R
G
R
V
E
E
F
A
S
G
W
--
G
S
RP
E
L
C
F
-----------
P
C
D
V
A
D
D
S
Q
I
E
A
V
F
A
A
L
G
K
H
W
D
G
-
L
D
I
I
V
H
S
V
G
F
A
P
G
D
Q
L
D
G
D
F
T
A
V
T
---
T
R
E
G
F
R
I
A
H
D
I
S
A
Y
S
F
I
A
L
A
K
A
G
R
E
M
M
KG
R
-
N
---
G
-
S
L
L
T
L
S
Y
L
G
A
E
R
T
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
G
S
L
G
A
-
E
G
T
R
V
N
A
V
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
A
A
N
E
R
Q
T
P
L
R
R
N
---
V
T
I
E
E
V
G
N
A
G
A
F
L
C
S
-
D
L
A
S
G
I
S
G
E
I
L
Y
V
D
G
G
F
N
--
T
T
A
M
G
-------------------
87
PsiBlast_CBE
78.46
45%
-120
- C1 -
3PJE
2
FABI_ECOLI
A:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
S
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
96
PsiBlast_CBE
78.43
45%
-118
- C1 -
1QG6
2
FABI_ECOLI
D:
[1-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
88
PsiBlast_CBE
78.39
45%
-118
- C1 -
4D46
2
?
B:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
------
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
--------------------
37
PsiBlast_CBE
78.39
44%
-118
- C1 -
2WYW
2
?
D:
[6-257]
---
L
S
G
K
K
A
L
V
M
G
V
T
N
Q
R
S
L
G
F
A
I
A
A
K
L
K
E
-
A
G
A
E
V
A
L
S
Y
Q
A
E
R
L
R
P
E
A
E
K
L
A
E
A
L
--
G
G
--
A
L
L
F
-----------
R
A
D
V
T
Q
D
E
E
L
D
A
L
F
A
G
V
K
E
A
F
G
G
-
L
D
Y
L
V
H
A
I
A
F
A
P
R
E
A
M
E
G
R
Y
I
D
-
T
---
R
R
Q
D
W
L
L
A
L
E
V
S
A
Y
S
L
V
A
V
A
R
R
A
E
P
L
L
--
R
-
E
---
G
G
G
I
V
T
L
T
Y
Y
A
S
E
K
V
V
P
K
Y
--
N
V
M
A
I
A
K
A
A
L
E
A
S
V
R
Y
L
A
Y
E
L
G
P
-
K
G
V
R
V
N
A
I
S
A
G
P
V
R
T
V
A
A
R
S
I
P
G
F
T
K
M
Y
D
R
V
A
Q
T
A
P
L
R
R
N
---
I
T
Q
E
E
V
G
N
L
G
L
F
L
L
S
-
P
L
A
S
G
I
T
G
E
V
V
Y
V
D
A
G
Y
H
--
I
M
G
M
E
-------------------
83
PsiBlast_CBE
78.30
45%
-118
- C1 -
1C14
2
FABI_ECOLI
A:
[2-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
32
PsiBlast_CBE
78.27
45%
-114
- C1 -
3OJF
2
FABI_BACCR
D:
[2-257]
-
E
L
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
EG
Q
E
--
S
L
V
L
-----------
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
-
T
---
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
--
T
-
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
--
I
L
G
L
--------------------
91
PsiBlast_CBE
78.03
45%
-122
- C1 -
4CV3
2
?
A:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
-----------------
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
57
PsiBlast_CBE
77.99
45%
-111
- C1 -
2QIO
2
?
A:
[1-256]
M
E
L
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
EG
Q
E
--
S
L
V
L
-----------
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
-
T
---
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
--
T
-
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
--
I
L
G
---------------------
90
PsiBlast_CBE
77.96
45%
-122
- C1 -
4CV3
2
?
B:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
-----------------
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
54
PsiBlast_CBE
77.93
45%
-109
- C1 -
2QIO
2
?
D:
[1-256]
M
E
L
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
EG
Q
E
--
S
L
V
L
-----------
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
-
T
---
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
--
T
-
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
--
I
L
G
---------------------
81
PsiBlast_CBE
77.89
45%
-118
- C1 -
1I2Z
2
FABI_ECOLI
A:
[2-258]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
42
PsiBlast_CBE
77.88
44%
-114
- C1 -
2WYV
2
?
B:
[6-257]
---
L
S
G
K
K
A
L
V
M
G
V
T
N
Q
R
S
L
G
F
A
I
A
A
K
L
K
E
-
A
G
A
E
V
A
L
S
Y
Q
A
E
R
L
R
P
E
A
E
K
L
A
E
A
L
--
G
G
--
A
L
L
F
-----------
R
A
D
V
T
Q
D
E
E
L
D
A
L
F
A
G
V
K
E
A
F
G
G
-
L
D
Y
L
V
H
A
I
A
F
A
P
R
E
A
M
E
G
R
Y
I
D
-
T
---
R
R
Q
D
W
L
L
A
L
E
V
S
A
Y
S
L
V
A
V
A
R
R
A
E
P
L
L
--
R
-
E
---
G
G
G
I
V
T
L
T
Y
Y
A
S
E
K
V
V
P
K
Y
--
N
V
M
A
I
A
K
A
A
L
E
A
S
V
R
Y
L
A
Y
E
L
G
P
-
K
G
V
R
V
N
A
I
S
A
G
P
V
R
T
------------
Y
D
R
V
A
Q
T
A
P
L
R
R
N
---
I
T
Q
E
E
V
G
N
L
G
L
F
L
L
S
-
P
L
A
S
G
I
T
G
E
V
V
Y
V
D
A
G
Y
H
--
I
M
G
M
E
L
------------------
89
PsiBlast_CBE
77.67
45%
-125
- C1 -
4D46
2
?
A:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
------------------
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
55
PsiBlast_CBE
77.55
45%
-110
- C1 -
2QIO
2
?
C:
[1-256]
M
E
L
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
EG
Q
E
--
S
L
V
L
-----------
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
-
T
---
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
--
T
-
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
--
I
L
G
---------------------
95
PsiBlast_CBE
77.51
45%
-118
- C1 -
3PJF
2
FABI_ECOLI
A:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
V
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
----------
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
80
PsiBlast_CBE
77.47
45%
-118
- C1 -
1I2Z
2
FABI_ECOLI
B:
[2-258]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
82
PsiBlast_CBE
77.44
45%
-117
- C1 -
1C14
2
FABI_ECOLI
B:
[2-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
72
PsiBlast_CBE
77.37
45%
-117
- C1 -
1MFP
3
FABI_ECOLI
B:
[2-259]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
L
-----------------
16
PsiBlast_PDB
77.32
44%
-114
- C1 -
2WYU
2
?
A:
[6-256]
---
L
S
G
K
K
A
L
V
M
G
V
T
N
Q
R
S
L
G
F
A
I
A
A
K
L
K
E
-
A
G
A
E
V
A
L
S
Y
Q
A
E
R
L
R
P
E
A
E
K
L
A
E
A
L
--
G
G
--
A
L
L
F
-----------
R
A
D
V
T
Q
D
E
E
L
D
A
L
F
A
G
V
K
E
A
F
G
G
-
L
D
Y
L
V
H
A
I
A
F
A
P
R
E
A
M
E
G
R
Y
I
D
-
T
---
R
R
Q
D
W
L
L
A
L
E
V
S
A
Y
S
L
V
A
V
A
R
R
A
E
P
L
L
--
R
-
E
---
G
G
G
I
V
T
L
T
Y
Y
A
S
E
K
V
V
P
K
Y
--
N
V
M
A
I
A
K
A
A
L
E
A
S
V
R
Y
L
A
Y
E
L
G
P
-
K
G
V
R
V
N
A
I
S
A
G
P
V
R
T
V
A
A
R
S
I
P
G
F
T
K
M
Y
D
R
V
A
Q
T
A
P
L
R
R
N
---
I
T
Q
E
E
V
G
N
L
G
L
F
L
L
S
-
P
L
A
S
G
I
T
G
E
V
V
Y
V
D
A
G
Y
H
--
I
M
G
---------------------
85
PsiBlast_CBE
77.25
45%
-119
- C1 -
4JQC
2
FABI_ECOLI
A:
[21-278]
M
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
73
PsiBlast_CBE
77.21
45%
-118
- C1 -
1MFP
2
FABI_ECOLI
A:
[2-259]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
L
-----------------
44
PsiBlast_CBE
77.21
44%
-110
- C1 -
2WYU
1
?
C:
[6-257]
---
L
S
G
K
K
A
L
V
M
G
V
T
N
Q
R
S
L
G
F
A
I
A
A
K
L
K
E
-
A
G
A
E
V
A
L
S
Y
Q
A
E
R
L
R
P
E
A
E
K
L
A
E
A
L
--
G
G
--
A
L
L
F
-----------
R
A
D
V
T
Q
D
E
E
L
D
A
L
F
A
G
V
K
E
A
F
G
G
-
L
D
Y
L
V
H
A
I
A
F
A
P
R
E
A
M
E
G
R
Y
I
D
-
T
---
R
R
Q
D
W
L
L
A
L
E
V
S
A
Y
S
L
V
A
V
A
R
R
A
E
P
L
L
--
R
-
E
---
G
G
G
I
V
T
L
T
Y
Y
A
S
E
K
V
V
P
K
Y
--
N
V
M
A
I
A
K
A
A
L
E
A
S
V
R
Y
L
A
Y
E
L
G
P
-
K
G
V
R
V
N
A
I
S
A
G
P
V
R
T
V
A
A
R
S
I
P
G
F
T
K
M
Y
D
R
V
A
Q
T
A
P
L
R
R
N
---
I
T
Q
E
E
V
G
N
L
G
L
F
L
L
S
-
P
L
A
S
G
I
T
G
E
V
V
Y
V
D
A
G
Y
H
--
I
M
G
M
E
-------------------
94
PsiBlast_CBE
77.19
45%
-116
- C1 -
3PJF
2
FABI_ECOLI
B:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
V
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
60
PsiBlast_CBE
76.98
47%
-114
- C1 -
4NR0
2
FABI_PSEAE
B:
[2-260]
-
G
F
L
T
G
K
R
A
L
I
V
G
V
A
S
K
L
S
I
A
S
G
I
A
A
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
R
G
R
V
E
E
F
A
S
G
W
--
G
S
RP
E
L
C
F
-----------
P
C
D
V
A
D
D
S
Q
I
E
A
V
F
A
A
L
G
K
H
W
D
G
-
L
D
I
I
V
H
S
V
G
F
A
P
G
D
Q
L
D
G
D
F
T
A
V
T
---
T
R
E
G
F
R
I
A
H
D
I
S
A
Y
S
F
I
A
L
A
K
A
G
R
E
M
M
KG
R
-
N
---
G
-
S
L
L
T
L
S
Y
L
G
A
E
R
T
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
G
S
L
G
A
-
E
G
T
R
V
N
A
V
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
A
A
N
E
R
Q
T
P
L
R
R
N
---
V
T
I
E
E
V
G
N
A
G
A
F
L
C
S
-
D
L
A
S
G
I
S
G
E
I
L
Y
V
D
G
G
F
N
--
T
T
A
M
G
-------------------
77
PsiBlast_CBE
76.97
45%
-119
- C1 -
1LX6
2
FABI_ECOLI
A:
[2-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
-------------
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
93
PsiBlast_CBE
76.89
45%
-123
- C1 -
4CV2
2
?
A:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
-------------------
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
38
PsiBlast_CBE
76.86
44%
-117
- C1 -
2WYW
2
?
C:
[6-257]
---
L
S
G
K
K
A
L
V
M
G
V
T
N
Q
R
S
L
G
F
A
I
A
A
K
L
K
E
-
A
G
A
E
V
A
L
S
Y
Q
A
E
R
L
R
P
E
A
E
K
L
A
E
A
L
--
G
G
--
A
L
L
F
-----------
R
A
D
V
T
Q
D
E
E
L
D
A
L
F
A
G
V
K
E
A
F
G
G
-
L
D
Y
L
V
H
A
I
A
F
A
P
R
E
A
M
E
G
R
Y
I
D
-
T
---
R
R
Q
D
W
L
L
A
L
E
V
S
A
Y
S
L
V
A
V
A
R
R
A
E
P
L
L
--
R
-
E
---
G
G
G
I
V
T
L
T
Y
Y
A
S
E
K
V
V
P
K
Y
--
N
V
M
A
I
A
K
A
A
L
E
A
S
V
R
Y
L
A
Y
E
L
G
P
-
K
G
V
R
V
N
A
I
S
A
G
P
V
R
T
V
A
A
R
S
I
P
G
F
T
K
M
Y
D
R
V
A
Q
T
A
P
L
R
R
N
---
I
T
Q
E
E
V
G
N
L
G
L
F
L
L
S
-
P
L
A
S
G
I
T
G
E
V
V
Y
V
D
A
G
Y
H
--
I
M
G
M
E
-------------------
33
PsiBlast_CBE
76.78
45%
-110
- C1 -
3OJF
2
FABI_BACCR
C:
[2-257]
-
E
L
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
EG
Q
E
--
S
L
V
L
-----------
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
-
T
---
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
--
T
-
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
--
I
L
G
L
--------------------
56
PsiBlast_CBE
76.73
45%
-108
- C1 -
2QIO
2
?
B:
[1-256]
M
E
L
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
EG
Q
E
--
S
L
V
L
-----------
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
-
T
---
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
--
T
-
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
--
I
L
G
---------------------
74
PsiBlast_CBE
76.37
45%
-118
- C1 -
1LXC
2
FABI_ECOLI
B:
[2-259]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
-------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
L
-----------------
76
PsiBlast_CBE
76.27
45%
-119
- C1 -
1LX6
2
FABI_ECOLI
B:
[2-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
-------------
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
86
PsiBlast_CBE
76.17
45%
-118
- C1 -
3PJE
2
FABI_ECOLI
B:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
S
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
92
PsiBlast_CBE
75.90
45%
-123
- C1 -
4CV2
2
?
B:
[2-256]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
------------------
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
84
PsiBlast_CBE
75.87
45%
-116
- C1 -
4JX8
2
FABI_ECOLI
A:
[21-278]
M
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
D
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
13
PsiBlast_PDB
75.76
48%
-112
- C1 -
4ZJU
2
?
A:
[12-267]
-
G
L
L
A
G
K
R
F
L
I
A
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
L
H
R
-
E
G
A
E
L
A
F
T
Y
P
N
E
K
L
K
K
R
V
D
E
F
A
E
Q
F
--
G
S
--
K
L
V
F
-----------
P
C
D
V
A
V
D
A
E
I
D
N
A
F
A
E
L
A
K
H
W
D
G
-
V
D
G
V
V
H
S
I
G
F
A
P
A
H
T
L
D
G
D
F
T
D
V
T
---
D
R
D
G
F
K
I
A
H
D
I
S
A
Y
S
F
V
A
M
A
R
A
A
K
P
L
L
--
Q
A
R
---
Q
G
C
L
L
T
L
T
Y
Q
G
S
E
R
V
M
P
N
Y
--
N
V
M
G
M
A
K
A
S
L
E
A
G
V
R
Y
L
A
S
S
L
G
V
-
D
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
A
A
S
G
I
K
S
F
R
K
M
L
D
A
N
E
K
V
A
P
L
K
R
N
---
V
T
I
E
E
V
G
N
A
A
L
F
L
C
S
-
P
W
A
S
G
I
T
G
E
I
L
Y
V
D
A
G
F
N
--
T
V
G
M
S
Q
S
-----------------
34
PsiBlast_CBE
75.70
45%
-110
- C1 -
3OJF
2
FABI_BACCR
B:
[2-257]
-
E
L
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
EG
Q
E
--
S
L
V
L
-----------
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
-
T
---
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
--
T
-
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
--
I
L
G
L
--------------------
79
PsiBlast_CBE
75.68
45%
-116
- C1 -
1I30
2
FABI_ECOLI
A:
[2-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
--------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
14
PsiBlast_PDB
75.46
45%
-111
- C1 -
3OJF
2
FABI_BACCR
A:
[1-257]
M
E
L
L
Q
G
K
T
F
V
V
M
G
V
A
N
Q
R
S
I
A
W
G
I
A
R
S
L
H
N
-
A
G
A
K
L
I
F
T
Y
A
G
E
R
L
E
R
N
V
R
E
L
A
D
T
L
EG
Q
E
--
S
L
V
L
-----------
P
C
D
V
T
N
D
E
E
L
T
A
C
F
E
T
I
K
Q
E
V
G
T
-
I
H
G
V
A
H
C
I
A
F
A
N
R
D
D
L
K
G
E
F
V
D
-
T
---
S
R
D
G
F
L
L
A
Q
N
I
S
A
F
S
L
T
A
V
A
R
E
A
K
K
V
M
--
T
-
E
---
G
G
N
I
L
T
L
T
Y
L
G
G
E
R
V
V
K
N
Y
--
N
V
M
G
V
A
K
A
S
L
E
A
S
V
K
Y
L
A
N
D
L
G
Q
-
H
G
I
R
V
N
A
I
S
A
G
P
I
R
T
L
S
A
K
G
V
G
D
F
N
S
I
L
R
E
I
E
E
R
A
P
L
R
R
T
---
T
T
Q
E
E
V
G
D
T
A
V
F
L
F
S
-
D
L
A
R
G
V
T
G
E
N
I
H
V
D
S
G
Y
H
--
I
L
G
L
--------------------
11
PsiBlast_PDB
75.19
49%
-117
- C1 -
4BKU
2
?
A:
[2-258]
-
G
F
L
D
G
K
R
I
L
L
T
G
L
L
S
N
R
S
I
A
Y
G
I
A
K
A
C
K
R
-
E
G
A
E
L
A
F
T
Y
V
G
D
R
F
K
D
R
I
T
E
F
A
A
E
F
--
G
S
--
E
L
V
F
-----------
P
C
D
V
A
D
D
A
Q
I
D
A
L
F
A
S
L
K
T
H
W
D
S
-
L
D
G
L
V
H
S
I
G
F
A
P
R
E
A
I
A
G
D
F
L
D
G
L
---
T
R
E
N
F
R
I
A
H
D
I
S
A
Y
S
F
P
A
L
A
K
A
A
L
P
M
L
--
S
-
D
---
D
A
S
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
T
M
G
L
A
K
A
A
L
E
A
S
V
R
Y
L
A
V
S
L
G
A
-
K
G
V
R
V
N
A
I
S
A
G
P
I
K
T
L
A
A
S
G
I
K
S
F
G
K
I
L
D
F
V
E
S
N
S
P
L
K
R
N
---
V
T
I
E
Q
V
G
N
A
G
A
F
L
L
S
-
D
L
A
S
G
V
T
A
E
V
M
H
V
D
S
G
F
N
AV
V
G
G
M
--------------------
78
PsiBlast_CBE
75.00
45%
-116
- C1 -
1I30
2
FABI_ECOLI
B:
[2-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
--------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
-------------------
75
PsiBlast_CBE
75.00
45%
-117
- C1 -
1LXC
2
FABI_ECOLI
A:
[2-259]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
-------
F
R
K
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
L
-----------------
100
PsiBlast_CBE
74.74
45%
-117
- C1 -
1DFI
1
FABI_ECOLI
D:
[1-257]
-
G
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
-
E
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
S
--
D
I
V
L
-----------
Q
C
D
V
A
E
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
K
-
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
G
D
Y
V
N
A
V
---
T
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
L
--
N
-
P
---
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
A
I
P
N
Y
--
N
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
A
M
G
P
-
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
----------
M
L
A
H
C
E
A
V
T
P
I
R
R
T
---
V
T
I
E
D
V
G
N
S
A
A
F
L
C
S
-
D
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
M
N
E
------------------
101
Fugue
70.90
42%
-132
- C1 -
1DFI
1
FABI_ECOLI
A:
[1-257]
G
-
F
L
S
G
K
R
I
L
V
T
G
V
A
S
K
L
S
I
A
Y
G
I
A
Q
A
M
H
R
E
-
G
A
E
L
A
F
T
Y
Q
N
D
K
L
K
G
R
V
E
E
F
A
A
Q
L
--
G
-------SD
I
V
L
Q
C
D
VAE------
D
A
S
I
D
T
M
F
A
E
L
G
K
V
W
P
-K
F
D
G
F
V
H
S
I
G
F
A
P
G
D
Q
L
D
-
G
D
Y
V
-
N
AVT-
R
E
G
F
K
I
A
H
D
I
S
S
Y
S
F
V
A
M
A
K
A
C
R
S
M
------LNP
G
S
A
L
L
T
L
S
Y
L
G
A
E
R
-
A
I
P
N
YN-
V
M
G
L
A
K
A
S
L
E
A
N
V
R
Y
M
A
N
-
A
M
G
P
E
G
V
R
V
N
A
I
S
A
G
P
I
R
T
L
---------
M
L
A
H
C
E
A
-
V
T
P
I
--
R
R
T
V
-
T
I
E
D
V
G
N
S
A
A
F
L
C
S
D-
L
S
A
G
I
S
G
E
V
V
H
V
D
G
G
F
S
--
I
A
A
-----------
M
N
E
-------