@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0183: (2015-12-13 )
MKDSFLFTSESVTEGHPDKMADQISDAVLDYIIERDKKAKVACETLVSNGFCMITGELKTSVYAPMQEIAREVVKKIGYTDALYGFDYRSAAVLNGIGEQSPDINQGVDREDGEIGAGDQGLMFGYACKETETLMPLPIHLAHQLAFALAQKRKDNTLPFLRPDGKSQVSVRYENNKPVSVDTIVISTQHSPEVSQKHLKEAVIEEIVYKVLPKEYLHDNIKFFINPTGKFVIGGPQGDAGLTGRKIIVDTYGGFCPHGGGAFSGKDPSKVDRSAAYAARYVAKNLVASGVCDKATVQLAYAIGVIEPVSIYVNTHNTSKHSSAELEKCVKSVFKLTPKGIIESLDLLRPIYSLTSAYGHFGRELEEFTWEKTNKVEEIKAFFKR
Atome Classification :
(30 SA)
.........10........20........30........40........50........60.---.......70........80........90........100......--.110-..-..--....120.......130.......140.......150..---.....160.......170....----.----..180.......190....-...200.......210.---....-..220----........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.........330.......340.......350.......360.......370.......380...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKD
S
F
L
F
TSESVTEGH
P
D
K
M
A
D
Q
I
S
D
A
V
L
D
Y
I
I
ERDKK
A
K
V
A
C
E
T
L
VSN
G
F
C
M
I
TGEL
K
T
S
V
---
Y
A
P
M
Q
E
I
A
R
E
V
V
K
KIGYTD
A
L
YGFDY
R
S
A
A
V
LNGIGEQSPDINQGV--DRE--DG-EI--GAGDQG
L
M
F
G
Y
ACKETETLMP
L
P
I
H
L
A
H
Q
L
A
F
A
L
A
Q
KRK---DNTL
P
F
LRPDGK
S
Q
V
S
V
R
YENN----K----
P
V
S
V
D
T
I
V
I
STQHSP
E
V
S
Q
-
K
H
L
K
E
A
V
I
E
E
I
V
Y
K
VL
P
---
K
E
Y
L
-HDN
I
-----
K
F
F
INPTG
K
F
V
I
GGPQGDAGLTG
R
K
I
I
V
DTYGGFCPHGGGAFSGK
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
L
V
ASGVCDK
A
T
V
Q
L
A
Y
A
IGV
I
E
P
V
S
I
Y
V
NTHNTSK--H
S
S
A
E
L
E
K
C
V
K
S
V
FKLT
P
K
G
I
I
E
S
L
D
L
L
R
P
I
Y
S
L
T
S
A
Y
G
H
F
G
R
E
L
E
E
F
T
WEKTN
K
V
E
E
I
K
A
F
FKR
48
HHSearch
97.63
59%
-81
- C4 -
3IML
-
METK_BURPS
A:
[1-388]
M
A
N
D
Y
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
I
S
D
A
I
L
D
A
I
L
A
Q
D
K
Y
S
R
V
A
A
E
T
L
C
N
T
G
L
V
V
L
A
G
E
I
T
T
T
A
---
N
I
D
Y
I
Q
I
A
R
D
T
I
K
R
I
G
Y
D
---------
G
C
A
V
L
V
A
Y
D
K
Q
S
P
-------------
N
L
-
D
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
E
L
M
P
L
P
I
H
L
S
H
R
L
V
E
R
Q
A
N
L
R
R
---
D
G
R
L
P
W
L
R
P
D
A
K
S
Q
V
T
V
R
Y
V
D
G
----
K
----
P
H
S
I
D
T
V
V
L
S
T
Q
H
A
P
E
I
D
L
-
P
A
L
R
E
A
V
I
E
E
V
I
K
P
T
L
P
---
A
D
L
I
-
K
G
D
I
-----
K
F
L
V
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
G
R
Y
V
A
K
N
I
V
A
A
G
L
A
S
R
A
L
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
V
M
V
N
T
F
G
T
G
R
--
V
S
D
E
T
I
T
K
L
V
R
E
H
F
D
L
R
P
K
G
I
I
Q
M
L
D
L
L
R
P
I
Y
E
K
T
A
A
Y
G
H
F
G
R
E
E
P
E
F
S
W
E
A
A
D
K
A
L
A
L
A
E
A
A
G
V
52
HHSearch
97.39
61%
-78
- C4 -
1P7L
8
METK_ECOLI
A:
[1-382]
--
A
K
H
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
D-
P
L
-
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
E
--
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
2
PsiBlast_PDB
96.97
62%
-79
- C4 -
1P7L
8
METK_ECOLI
A:
[4-377]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
--
D
P
L
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
--
E
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
24
PsiBlast_CBE
96.95
62%
-80
- C4 -
1P7L
8
METK_ECOLI
D:
[4-377]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
--
D
P
L
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
--
E
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
25
PsiBlast_CBE
96.91
62%
-80
- C4 -
1P7L
9
METK_ECOLI
C:
[4-377]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
--
D
P
L
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
--
E
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
3
PsiBlast_PDB
96.91
62%
-80
- C4 -
1RG9
8
METK_ECOLI
A:
[4-377]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
--
D
P
L
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
--
E
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
22
PsiBlast_CBE
96.89
62%
-80
- C4 -
1RG9
9
METK_ECOLI
C:
[4-377]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
--
D
P
L
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
--
E
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
1
PsiBlast_PDB
96.86
62%
-81
- C4 -
1FUG
-
METK_ECOLI
A:
[4-377]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
--
D
P
L
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
--
E
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
21
PsiBlast_CBE
96.79
62%
-80
- C4 -
1RG9
9
METK_ECOLI
D:
[4-377]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
--
D
P
L
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
--
E
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
26
PsiBlast_CBE
96.64
62%
-80
- C4 -
1P7L
8
METK_ECOLI
B:
[4-377]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
--
D
P
L
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
--
E
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
4
PsiBlast_PDB
96.61
60%
-83
- C4 -
3IML
-
METK_BURPS
A:
[1-378]
M
A
N
D
Y
L
F
T
S
E
S
V
S
E
G
H
P
D
K
V
A
D
Q
I
S
D
A
I
L
D
A
I
L
A
Q
D
K
Y
S
R
V
A
A
E
T
L
C
N
T
G
L
V
V
L
A
G
E
I
T
T
T
A
---
N
I
D
Y
I
Q
I
A
R
D
T
I
K
R
I
G
Y
D
---------
G
C
A
V
L
V
A
Y
D
K
Q
S
P
----------------
N
L
DQ
G
A
G
D
Q
G
L
M
F
G
Y
A
C
D
E
T
P
E
L
M
P
L
P
I
H
L
S
H
R
L
V
E
R
Q
A
N
L
R
R
---
D
G
R
L
P
W
L
R
P
D
A
K
S
Q
V
T
V
R
Y
V
D
G
----
K
----
P
H
S
I
D
T
V
V
L
S
T
Q
H
A
P
E
I
D
L
-
P
A
L
R
E
A
V
I
E
E
V
I
K
P
T
L
P
---
A
D
L
I
-
K
G
D
I
-----
K
F
L
V
N
P
T
G
R
F
V
I
G
G
P
Q
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
A
A
P
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
G
R
Y
V
A
K
N
I
V
A
A
G
L
A
S
R
A
L
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
V
M
V
N
T
F
G
T
G
R
--
V
S
D
E
T
I
T
K
L
V
R
E
H
F
D
L
R
P
K
G
I
I
Q
M
L
D
L
L
R
P
I
Y
E
K
T
A
A
Y
G
H
F
G
R
E
E
P
E
F
S
W
E
A
A
D
K
A
L
A
L
A
E
A
A
G
V
23
PsiBlast_CBE
96.38
62%
-80
- C4 -
1RG9
8
METK_ECOLI
B:
[4-377]
-----
L
F
T
S
E
S
V
S
E
G
H
P
D
K
I
A
D
Q
I
S
D
A
V
L
D
A
I
L
E
Q
D
P
K
A
R
V
A
C
E
T
Y
V
K
T
G
M
V
L
V
G
G
E
I
T
T
S
A
---
W
V
D
I
E
E
I
T
R
N
T
V
R
E
I
G
Y
V
H
S
D
M
G
F
D
A
N
S
C
A
V
L
S
A
I
G
K
Q
S
P
D
I
N
Q
G
V
--
D
R
A
--
D
P
L
E
Q
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
N
E
T
D
V
L
M
P
A
P
I
T
Y
A
H
R
L
V
Q
R
Q
A
E
V
R
K
---
N
G
T
L
P
W
L
R
P
D
A
K
S
Q
V
T
F
Q
Y
D
D
G
----
K
----
I
V
G
I
D
A
V
V
L
S
T
Q
H
S
E
E
I
D
Q
-
K
S
L
Q
E
A
V
M
E
E
I
I
K
P
I
L
P
---
A
E
W
L
-
T
S
A
T
-----
K
F
F
I
N
P
T
G
R
F
V
I
G
G
P
M
G
D
C
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
M
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
A
R
Y
V
A
K
N
I
V
A
A
G
L
A
D
R
C
E
I
Q
V
S
Y
A
I
G
V
A
E
P
T
S
I
M
V
E
T
F
G
T
E
K
--
V
P
S
E
Q
L
T
L
L
V
R
E
F
F
D
L
R
P
Y
G
L
I
Q
M
L
D
L
L
H
P
I
Y
K
E
T
A
A
Y
G
H
F
G
R
--
E
H
F
P
W
E
K
T
D
K
A
Q
L
L
R
D
A
A
G
L
9
PsiBlast_PDB
96.29
54%
-80
- C4 -
2P02
2
METK2_HUMAN
A:
[18-395]
---
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
HL
D
R
N
--
E
E
-
D
I
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
----
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
--
D
S
F
P
W
E
V
P
K
K
L
K
Y
-------
35
PsiBlast_CBE
95.82
54%
-84
- C4 -
4KTV
7
METK2_HUMAN
B:
[18-395]
---
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
HL
D
R
N
--
E
E
-
D
I
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
----
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
--
D
S
F
P
W
E
V
P
K
K
L
K
Y
-------
51
HHSearch
95.77
55%
-78
* C4 *
2P02
2
METK2_HUMAN
A:
[17-394]
--
G
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
--
H
L
D
RN
E
E
-
D
I
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
RG
A
V
L
----
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
D
--
S
F
P
W
E
V
P
K
K
L
K
Y
-------
38
PsiBlast_CBE
95.73
54%
-81
- C4 -
4KTT
14
METK2_HUMAN
B:
[18-395]
---
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
HL
D
R
N
--
E
E
-
D
I
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
----
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
--
D
S
F
P
W
E
V
P
K
K
L
K
Y
-------
36
PsiBlast_CBE
95.71
54%
-81
- C4 -
4KTT
6
METK2_HUMAN
D:
[18-395]
---
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
HL
D
R
N
--
E
E
-
D
I
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
----
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
--
D
S
F
P
W
E
V
P
K
K
L
K
Y
-------
31
PsiBlast_CBE
95.53
54%
-86
- C4 -
4NDN
5
METK2_HUMAN
C:
[17-394]
---
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
--------------------------
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
----
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
--
D
S
F
P
W
E
V
P
K
K
L
K
Y
-------
32
PsiBlast_CBE
95.40
54%
-80
- C4 -
4NDN
9
METK2_HUMAN
B:
[17-394]
---
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
HL
D
R
N
--
E
E
-
D
I
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
----
R
G
A
V
L
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
--
D
S
F
P
W
E
V
P
K
K
L
K
Y
-------
30
PsiBlast_CBE
95.02
54%
-78
- C4 -
4NDN
6
METK2_HUMAN
D:
[17-394]
---
T
F
L
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
Q
Q
D
P
D
A
K
V
A
C
E
T
V
A
K
T
G
M
I
L
L
A
G
E
I
T
S
R
A
---
A
V
D
Y
Q
K
V
V
R
E
A
V
K
H
I
G
Y
D
D
S
S
K
G
F
D
Y
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
G
V
HL
D
R
N
--
E
E
-
D
I
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
A
K
L
A
E
L
R
R
---
N
G
T
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
----
R
GAVL
P
I
R
V
H
T
I
V
I
S
V
Q
H
D
E
E
V
C
L
-
D
E
M
R
D
A
L
K
E
K
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
G
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
S
H
P
L
S
I
S
I
F
H
Y
G
T
S
Q
--
K
S
E
R
E
L
L
E
I
V
K
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
R
T
A
A
Y
G
H
F
G
R
--
D
S
F
P
W
E
V
P
K
K
L
K
Y
-------
12
PsiBlast_PDB
93.97
52%
-85
- C4 -
1QM4
9
METK1_RAT
A:
[18-394]
---
A
F
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
-
D
V
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
----
N
G
A
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
--
S
E
F
P
W
E
V
P
K
K
L
V
F
-------
13
PsiBlast_PDB
93.96
52%
-84
- C4 -
1O90
8
METK1_RAT
A:
[18-394]
---
A
F
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
-
D
V
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
----
N
G
A
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
--
S
E
F
P
W
E
V
P
K
K
L
V
F
-------
17
PsiBlast_PDB
93.90
52%
-82
- C4 -
2OBV
6
METK1_HUMAN
A:
[7-382]
----
F
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
V
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
D
I
A
Q
C
V
HL
D
R
N
--
E
E
-
D
V
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
I
L
A
H
K
L
N
A
R
M
A
D
L
R
R
---
S
G
L
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
M
Q
D
----
N
G
A
V
I
P
V
R
I
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
E
M
R
R
A
L
K
E
Q
V
I
R
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
V
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
Q
--
K
T
E
R
E
L
L
D
V
V
H
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
--
S
E
F
P
W
E
V
P
R
K
L
V
F
-------
40
PsiBlast_CBE
93.68
52%
-84
- C4 -
1O9T
8
METK1_RAT
A:
[18-394]
---
A
F
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
-
D
V
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
----
N
GA
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
--
S
E
F
P
W
E
V
P
K
K
L
V
F
-------
50
HHSearch
93.51
54%
-85
- C4 -
3S82
5
METK_MYCA1
A:
[9-407]
---
G
R
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
----------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
E
D
D
----
V
----
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
N
D
L
A
H
D
T
L
D
T
S
S
T
-----
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
14
PsiBlast_PDB
93.42
52%
-84
- C4 -
1O92
9
METK1_RAT
A:
[18-394]
---
A
F
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
-
D
V
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
----
N
G
A
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
--
S
E
F
P
W
E
V
P
K
K
L
V
F
-------
15
PsiBlast_PDB
93.39
52%
-84
- C4 -
1O93
8
METK1_RAT
A:
[18-394]
---
A
F
M
F
T
S
E
S
V
G
E
G
H
P
D
K
I
C
D
Q
I
S
D
A
V
L
D
A
H
L
K
Q
D
P
N
A
K
V
A
C
E
T
V
C
K
T
G
M
V
L
L
C
G
E
I
T
S
M
A
---
M
I
D
Y
Q
R
V
V
R
D
T
I
K
H
I
G
Y
D
D
S
A
K
G
F
D
F
K
T
C
N
V
L
V
A
L
E
Q
Q
S
P
--------------
E
-
D
V
--
G
A
G
D
Q
G
L
M
F
G
Y
A
T
D
E
T
E
E
C
M
P
L
T
I
V
L
A
H
K
L
N
T
R
M
A
D
L
R
R
---
S
G
V
L
P
W
L
R
P
D
S
K
T
Q
V
T
V
Q
Y
V
Q
D
----
N
G
A
V
I
P
V
R
V
H
T
I
V
I
S
V
Q
H
N
E
D
I
T
L
-
E
A
M
R
E
A
L
K
E
Q
V
I
K
A
V
V
P
---
A
K
Y
L
-
D
E
D
T
-----
I
Y
H
L
Q
P
S
G
R
F
V
I
G
G
P
Q
G
D
A
G
V
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
Y
T
K
V
D
R
S
A
A
Y
A
A
R
W
V
A
K
S
L
V
K
A
G
L
C
R
R
V
L
V
Q
V
S
Y
A
I
G
V
A
E
P
L
S
I
S
I
F
T
Y
G
T
S
K
--
K
T
E
R
E
L
L
E
V
V
N
K
N
F
D
L
R
P
G
V
I
V
R
D
L
D
L
K
K
P
I
Y
Q
K
T
A
C
Y
G
H
F
G
R
--
S
E
F
P
W
E
V
P
K
K
L
V
F
-------
5
PsiBlast_PDB
92.71
52%
-79
- C4 -
3S82
5
METK_MYCA1
A:
[11-404]
-----
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
----------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
E
D
D
----
V
----
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
-
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
---
N
D
L
A
-
H
D
T
L
DTSS
T
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
27
PsiBlast_CBE
92.42
52%
-80
- C4 -
3S82
4
METK_MYCA1
B:
[11-404]
-----
L
F
T
S
E
S
V
T
E
G
H
P
D
K
I
C
D
A
I
S
D
S
V
L
D
A
L
L
A
Q
D
P
R
S
R
V
A
V
E
T
L
V
T
T
G
Q
V
H
V
V
G
E
V
T
T
T
A
K
E
A
F
A
D
I
T
N
T
V
R
E
R
I
L
D
I
G
Y
D
S
S
D
K
G
F
D
G
A
S
C
G
V
N
I
G
I
G
A
Q
S
P
----------------------
G
D
Q
G
L
M
F
G
Y
A
I
N
D
T
P
E
R
M
P
L
P
I
A
L
A
H
R
L
S
R
R
L
T
E
V
R
K
---
N
G
V
L
P
Y
L
R
P
D
G
K
T
Q
V
T
I
E
F
E
D
D
----
V
----
P
V
R
L
D
T
V
V
I
S
T
Q
H
A
A
D
I
D
L
-
E
N
T
L
T
P
D
I
R
E
K
V
L
N
T
V
L
---
N
D
L
A
-
H
D
T
L
DTSST
R
L
L
V
N
P
T
G
K
F
V
V
G
G
P
M
G
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
A
R
H
G
G
G
A
F
S
G
K
D
P
S
K
V
D
R
S
A
A
Y
A
M
R
W
V
A
K
N
I
V
A
A
G
L
A
E
R
V
E
V
Q
V
A
Y
A
I
G
K
A
A
P
V
G
L
F
I
E
T
F
G
T
A
T
--
V
D
P
V
K
I
E
K
I
V
P
E
V
F
D
L
R
P
G
A
I
I
R
D
L
D
L
L
R
P
I
Y
A
Q
T
A
A
Y
G
H
F
G
R
T
D
V
E
L
P
W
E
Q
L
N
K
V
D
D
L
K
R
A
I
--
18
PsiBlast_PDB
90.54
46%
-79
- C4 -
4ODJ
4
?
A:
[29-409]
--
E
Q
F
L
F
S
S
E
S
V
C
S
G
H
P
D
K
L
C
D
Q
I
S
D
A
I
L
D
A
C
L
E
Q
D
P
E
S
F
V
A
C
E
T
C
T
K
T
G
F
I
M
V
F
G
E
I
T
T
K
A
---
N
V
N
Y
E
R
V
V
R
E
T
V
K
E
I
G
Y
D
S
E
E
K
G
L
D
Y
K
T
M
D
V
I
I
K
L
E
Q
Q
S
N
Q
I
A
G
C
V
HV
D
K
N
--
V
E
-
D
I
--
G
A
G
D
Q
G
M
M
F
G
Y
A
T
N
E
T
K
E
L
M
P
L
T
H
V
L
A
T
S
I
T
R
E
L
D
Y
I
R
M
KGV
S
S
R
V
G
W
L
R
P
D
G
K
A
Q
V
T
V
E
Y
N
C
K
----
H
G
V
L
I
P
K
R
I
H
T
I
L
V
S
V
Q
H
D
E
N
I
E
N
-
E
E
I
R
E
F
V
L
E
N
V
I
K
K
V
C
P
---
S
D
L
M
-
D
K
E
T
-----
R
I
L
I
N
P
S
G
R
F
T
I
G
G
P
A
A
D
A
G
L
T
G
R
K
I
I
V
D
T
Y
G
G
W
G
A
H
G
G
G
A
F
S
G
K
D
A
T
K
V
D
R
S
G
A
Y
M
A
R
L
V
A
K
S
I
V
F
S
G
L
C
S
R
C
L
V
Q
V
S
Y
G
I
G
I
A
R
P
L
S
L
Y
I
N
T
F
G
T
A
K
DG
Y
N
D
T
K
L
L
E
I
V
N
K
V
F
D
F
R
P
G
I
L
I
K
Q
L
N
L
K
S
P
I
F
K
K
T
S
S
G
G
H
F
G
R
S
E
K
E
F
L
W
E
K
P
I
I
L
Q
--------