@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0187: (2015-12-13 )
MKIVIDLMGADHGVLPIIEGVSRALENKSFSVVLVGDKDKATPFISKELASKVEMIHTQDYIKMEEAATEAIKRKESSIYLGMDILKNGADALISAGHSGATMGLATLRLGRIKGVERPAICTLMPSVGKRPSVLLDAGANTDCKPEYLIDFALMGYEYAKSVLHYDSPKVGLLSNGEEDIKGNTLVKETHKMLKAYDFFYGNVEGSDIFKGVVDVVVCDGFMGNVVLKTTEGVASAIGSIFKDEIKSSFKSKMGALMLKNAFGILKQKTDYAEYGGAPLLGVNKSVIISHGKSNARAVECAIYQAISAVESQVCLRITQAFESLKSQSFESQSDQQDA
Atome Classification :
(20 SA)
--------------------------------------------------.........10.......--------.20......-..--30.........40........50-.-......-----------------..----60-------------------.--...-------------.--------------....70.-------------...-..--.--.80........-90...-----...--.--..100....-----...110..------...---.------.120......-.-----130.......----140-------....-------....------150..------..------...160......-----.170.-----..----...------------------------.180--..---..---.---.-..-----190...--..--.------.200.....-...210-..--.......--220-----------------........230.......240.....----------------....250.......260.------....---..270.......280..----.....290.......300.......310-........320.......330.......---------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------
M
K
I
V
I
D
LMGADH
G
V
L
P
I
I
--------
E
G
V
S
R
A
LEN-K
S
--
F
-
S
V
V
L
VGDKDKATP
F
I
S
K
E
L
A
--
S
-
K
V
E
M
IH-----------------
T
Q
----
D
--------------------
Y
--
I
K
M
-------------
E
--------------
E
A
A
T
E
A
I
-------------
K
RK-ES--
S
--
I
Y
L
G
M
D
I
L
KN
G
-
A
-
D
A
L
-----
I
SA--G--HSG
A
T
M
G
L
A
-----
T
L
R
LGRIK------GVE---R------PA
I
C
T
LMPSV-G-----KRP
S
V
L
L
DAG----A-N-------TDC
K
-------
P
E
Y
L
------
I
D
F
A
L
------
M
G
------
Y
E
Y
A
K
S
V
LHYDS-----PKVGL-----LS----NGE------------------------EDI---KG---
N
T
---
L
---
V
-
K
E
-----
T
H
K
M
L
K
--
A
Y
--
D
------
F
F
-YGNV
E
G
-
S
D
I
F
---
K
G
--
V
V
D
V
VVC--DG------------------FMG
N
V
V
L
KT
T
E
G
V
A
S
A
I
G
S
--
I
F
K
D
E
----------------
I
K
S
S
F
K
S
K
M
G
A
L
M
L
K
N
A
F
------
G
I
L
K---QKTD
Y
A
EYGGA
P
L
LGVN----
K
S
V
I
I
SHGKSN
A
R
A
V
E
C
A
I
Y
Q
A
I
S
A
V
E
--
S
Q
V
C
L
R
I
T
Q
A
F
E
S
L
K
S
QSFESQSDQQDA---------------------
11
HHSearch
75.08
40%
5
- C3 -
1VI1
-
PLSX_BACSU
A:
[1-333]
--------------------------------------------------
L
R
I
A
V
D
A
M
G
G
D
H
A
P
K
A
V
I
--------
D
G
V
I
K
G
I
E
A
-
F
D
--
D
L
H
I
T
L
V
G
D
K
T
T
I
E
S
H
L
T
T
T
S
---
D
-
R
I
T
V
L
H
-----------------
A
D
----
E
--------------------
V
--
I
E
P
-------------
T
--------------
D
E
P
V
R
A
V
-------------
R
R
K
K
N
S
--
S
--
M
V
L
M
A
Q
E
V
A
E
N
R
A
-
D
A
C
-----
I
S
A
--
G
--
N
T
G
A
L
M
T
A
G
-----
L
F
I
V
G
R
I
K
------
G
I
D
---
R
------
P
A
L
A
P
T
L
P
T
V
-
S
-----
G
D
G
F
L
L
L
D
V
G
----
A
-
N
-------
V
D
A
K
-------
P
E
H
L
------
V
Q
Y
A
I
------
M
G
------
S
V
Y
S
Q
Q
V
R
G
V
T
S
-----
P
R
V
G
L
-----
L
N
----
V
G
T
------------------------
E
D
K
---
K
G
---
N
E
---
L
---
T
-
K
Q
-----
T
F
Q
I
L
K
--
E
T
AN
I
------
N
F
-
I
G
N
V
E
A
-
R
D
L
L
---
D
D
--
V
A
D
V
V
V
T
--
D
G
------------------
F
T
G
N
V
T
L
K
T
L
E
G
S
A
L
S
I
F
K
--
M
M
R
D
V
----------------
M
T
S
T
L
-------
V
L
K
P
K
L
------
K
E
M
K
---
M
K
M
E
Y
S
N
Y
G
G
A
S
L
F
G
L
K
----
A
P
V
I
K
A
H
G
S
S
D
S
N
A
V
F
R
A
I
R
Q
A
R
E
M
V
S
--
Q
N
V
A
A
L
I
Q
E
E
V
K
E
E
K
T
D
E
-------------------------------
1
PsiBlast_PDB
74.42
38%
8
- C3 -
1VI1
-
PLSX_BACSU
A:
[1-331]
--------------------------------------------------
L
R
I
A
V
D
A
M
G
G
D
H
A
P
K
A
V
I
--------
D
G
V
I
K
G
I
E
A
F
D
D
--
L
-
H
I
T
L
V
G
D
K
T
T
I
E
S
H
L
T
T
-
T
S
--
D
-
R
I
T
V
L
H
-----------------
A
D
----
E
--------------------
V
--
I
E
P
-------------
T
--------------
D
E
P
V
R
A
V
-------------
R
R
K
-
K
N
--
S
S
M
V
L
M
A
Q
E
V
A
E
N
R
-
A
-
D
A
C
-----
I
S
A
--
G
--
N
T
G
A
L
M
T
A
G
-----
L
F
I
V
G
R
I
K
------
G
I
D
---
R
------
P
A
L
A
P
T
L
P
T
V
-
S
-----
G
D
G
F
L
L
L
D
V
G
----
A
-
N
-------
V
D
A
K
-------
P
E
H
L
------
V
Q
Y
A
I
------
M
G
------
S
V
Y
S
Q
Q
V
R
G
V
T
S
-----
P
R
V
G
L
-----
L
N
----
V
G
T
------------------------
E
D
K
---
K
G
---
N
E
---
L
---
T
-
K
Q
-----
T
F
Q
I
L
K
E
T
A
N
--
I
------
N
F
-
I
G
N
V
E
A
-
R
D
L
L
---
D
D
--
V
A
D
V
V
V
T
--
D
G
------------------
F
T
G
N
V
T
L
K
T
L
E
G
S
A
L
S
I
F
K
--
M
M
R
D
V
----------------
M
T
S
T
L
-------
V
L
K
P
K
L
------
K
E
M
K
---
M
K
M
E
Y
S
N
Y
G
G
A
S
L
F
G
L
K
----
A
P
V
I
K
A
H
G
S
S
D
S
N
A
V
F
R
A
I
R
Q
A
R
E
M
V
S
--
Q
N
V
A
A
L
I
Q
E
E
V
K
E
E
K
T
D
E
-------------------------------
18
HHSearch
74.09
19%
-75
- C3 -
3UF6
1
?
A:
[20-290]
---------------------------------------------------
V
F
A
V
--
A
G
A
D
-
D
-
E
V
V
L
--------
E
T
I
R
L
A
L
K
Q
--
K
--
L
G
K
F
L
L
F
G
K
K
E
D
K
T
L
T
A
N
------
E
-
S
V
T
W
I
Q
-----------------
T
D
----
T
--------------------
A
------------------------------------
E
A
A
-------------------------
A
Q
G
A
I
L
A
V
K
N
K
E
A
-
D
I
L
-----
V
K
G
F-
I
--
P
T
A
T
L
M
H
H
--------
V
L
K
K
E
N
------
G
L
R
TD
Q
L
------
L
S
Q
I
A
I
F
D
I
P
-
T
Y----
H
K
P
L
L
I
T
D
C
A
----
M
-
N
-------
V
A
P
K
-------
T
K
E
K
------
I
A
I
T
E
------
N
A
------
L
A
V
A
H
Q
-
I
G
I
T
N
-----
P
K
I
A
L
-----
L
S
----
A
V
E
------------------------
E
V
T
---
A
K
---
M
P
---
S
---
T
-
L
E
-----
A
Q
E
V
V
Q
--
H
F
----------------
G
N
-
Q
I
S
V
---
S
G
PL
A
L
D
V
A
I
S
--------------------------------
K
E
A
A
L
--------
H
K
G
----------------
I
T
-
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
E
T
G
N
A
L
Y
K
S
L
---
V
Y
F
A
G
A
K
-
V
G
S
A
V
V
G
A
K
----
V
P
I
V
I
S
S
R
N
D
S
P
E
N
K
L
A
S
F
I
L
T
V
R
L
V
E
---------------------------------------------------
16
HHSearch
73.08
17%
-70
- C3 -
2AF4
2
PTAS_METTE
C:
[18-330]
---------------------------------------------------
T
I
A
L
P
--
E
T
E
-
D
I
-
R
T
L
--------
Q
A
A
A
K
I
L
E
R
--
G
--
I
A
D
I
V
L
V
G
N
E
A
D
I
K
A
L
A
G
D
L
D
L
--
S
-
K
A
K
I
V
D
-----------------
P
K
----
T
--------------------
Y
--
E
K
K
-------------
D
EYINAFYELRKHKG
I
T
L
E
N
A
--------------
A
E
I
M
S
D
--
Y
--
V
Y
F
A
V
M
M
A
K
L
G
E
V
-
D
G
V
-----
V
S
G
AA
H
--
S
S
S
D
T
L
R
P
A
-----
V
Q
I
V
K
T
A
K
------
G
A
A
---
L
------
A
S
A
F
F
I
I
S
V
P
-
D
CEYGS
D
G
T
F
L
F
A
D
S
G
----
M
-
V
-------
E
M
P
S
-------
V
E
D
V
------
A
N
I
A
V
------
I
S
------
A
K
T
F
E
L
-
L
V
Q
D
V
-----
P
K
V
A
M
-----
L
S
----
Y
S
T
------------------------
K
G
S
---
A
K
---
S
K
LTE
A
---
T
-
I
A
-----
S
T
K
L
A
Q
--
E
L
----------------
A
P
-
D
I
A
I
---
D
G
EL
Q
V
D
A
A
I
V
--------------------------------
P
K
V
A
A
--------
S
K
A
----------------
P
-
G
S
P
V
A
G
K
A
N
V
F
I
F
P
D
L
NCGNIA
Y
K
I
A
---
Q
R
L
A
K
A
E
A
Y
G
P
I
T
Q
G
L
A
----
K
P
I
N
D
L
S
R
G
C
S
D
E
D
I
V
G
A
V
A
I
T
C
V
Q
A
A
--
A
Q
D
K
---------------------------------------------
34
Fugue
71.12
18%
-75
- C3 -
3TNG
7
?
A:
[5-291]
--------------------------------------TKSRFFSDVAET
S
S
F
V
F
A
V
A
G
A
D
D
--
E
V
V
L
--------
E
T
I
R
L
A
L
K
Q
-
K
L
--
G
-
K
F
L
L
F
G
K
K
E
D
K
T
L
T
A
N
E
S
-------
V
T
W
I
Q
-----------------
T
D
----
T
--------------------
A
--
E
A
A
-------------
A
--------------
Q
G
A
I
L
A
V
-------------
K
N
K
-
E
A
--
D
--
I
L
V
K
G
F
I
P
T
A
T
-
L
M
H
H
V
-----
L
K
K
--
E
--
N
G
------------------
L
R
------
T
D
Q
---
L
------
L
S
Q
I
A
I
F
D
I
P
-
T
-----
Y
H
K
P
L
L
I
T
D
C
----
A
M
N
-------
V
A
P
K
-------
T
K
E
K
------
I
A
I
T
E
------
N
A
------
L
A
V
A
H
Q
-
I
G
I
T
N
-----
P
K
I
A
L
-----
L
S
----
A
V
E
------------------------
E
-------------------------------------
V
--
T
------
A
K
M
P
S
T
L
E
A
-
Q
E
V
V
---
Q
H
--
F
G
N
Q
I
S
V
--
S
G
------------------
P
L
A
L
D
V
A
I
S
K
E
A
A
L
H
---------
K
G
----------------
I
T
D
S
S
A
G
E
A
D
I
L
I
A
P
N
I
E
------
T
G
N
A
---
L
Y
K
S
L
V
Y
F
A
G
A
K
V
G
S
A
V
V
GAK
V
P
I
V
I
S
S
R
N
D
S
P
E
N
K
L
A
S
F
I
L
T
V
R
L
V
E
--
K
------------------------------------------------
17
HHSearch
70.64
20%
-72
- C3 -
1TD9
6
PTAS_BACSU
A:
[29-328]
----------------------------------------------------------
E
G
L
-
D
E
-
R
I
L
--------
E
A
V
S
K
L
A
G
N
--
K
--
V
L
N
P
I
V
I
G
N
E
N
E
I
Q
A
K
A
K
E
L
N
L
TL
G
-
G
V
K
I
Y
D
-----------------
P
H
----
T
--------------------
Y
--
E
G
M
-------------
E
D
L
V
Q
A
F
V
E
R
R
K
GK-
A
T
E
E
Q
A
--------------
R
K
A
L
L
D
--
E
--
N
Y
F
G
T
M
L
V
Y
K
G
L
A
-
D
G
L
-----
V
S
G
AA
H
--
S
T
A
D
T
V
R
P
A
-----
L
Q
I
I
K
T
K
E
------
G
V
K
---
K
------
T
S
G
V
F
I
M
A
R
G
-------
E
E
Q
Y
V
F
A
D
C
A
----
I
-
N
-------
I
A
P
D
-------
S
Q
D
L
------
A
E
I
A
I
------
E
S
------
A
N
T
A
K
-
M
F
D
I
-
E
-----
P
R
V
A
M
-----
L
S
----
F
S
T
------------------------
K
G
S
AKS
D
E
---
T
E
---
K
---
V
-
A
D
-----
A
V
K
I
A
K
--
E
K
----------------
A
P
-
E
L
T
L
---
D
G
EF
Q
F
D
A
A
F
V
--------------------------------
P
S
V
A
E
--------
K
K
A
----------------
P
-
D
S
E
I
K
G
D
A
N
V
F
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
---
Q
R
L
G
N
F
E
A
V
G
P
I
L
Q
G
L
N
----
M
P
V
N
D
L
S
R
G
C
N
A
E
D
V
Y
N
L
A
L
I
T
A
A
Q
A
L
---------------------------------------------------
14
HHSearch
67.76
14%
-72
- C3 -
1VMI
2
EUTD_ECOLI
A:
[33-335]
----------------------------------------------------------
D
A
L
-
D
Q
-
R
V
L
--------
K
A
A
Q
Y
L
H
Q
Q
--
G
--
L
A
T
P
I
L
V
A
N
P
F
E
L
R
Q
F
A
L
S
H
G
V
AM
D
-
G
L
Q
V
I
D
-----------------
P
H
----
G
--------------------
N
--
L
A
M
R
E
E
F
A
H
R
W
L
A
R
AG
E
--------------
K
T
P
P
D
A
--------------
L
E
K
L
T
D
--
P
--
L
M
F
A
A
A
M
V
S
A
G
K
A
-
D
V
C
-----
I
A
G
N-
L
S-
S
T
A
N
V
L
R
A
G
-----
L
R
I
I
G
L
Q
P
------
G
C
K
---
T
------
L
S
S
I
F
L
M
L
P
Q
Y
S
-----
G
P
A
L
G
F
A
D
C
S
----
V
-
V
-------
P
Q
P
T
-------
A
A
Q
L
------
A
D
I
A
L
------
A
S
------
A
E
T
W
R
A
I
T
G
E
-
E
-----
P
R
V
A
M
-----
L
S
----
F
S
S
------------------------
N
G
S
---
A
R
H
P
C
V
A
---
N
---
V
-
Q
Q
-----
A
T
E
I
V
R
--
E
R
----------------
A
P
-
K
L
V
V
---
D
G
EL
Q
F
D
A
A
F
V
--------------------------------
P
E
V
A
A
--------
Q
K
A
----------------
P
-
A
S
P
L
Q
G
K
A
N
V
M
V
F
P
S
L
E
A
G
N
I
G
Y
K
I
A
---
Q
R
L
G
G
Y
R
A
V
G
P
L
I
Q
G
L
A
----
A
P
M
H
D
L
S
R
G
C
S
V
Q
E
I
I
E
L
A
L
V
A
A
V
P
R
----------------------------------------------------
13
HHSearch
65.68
15%
-80
- C3 -
1YCO
1
?
A:
[2-274]
--------------------------------------------------
I
T
V
S
I
A
-
G
G
S
Q
---
P
E
I
L
--------
Q
L
V
K
K
A
L
K
E
-
A
E
Q
P
L
-
Q
F
I
V
F
D
T
N
E
N
L
D
T
----
E
----
N
-
L
W
K
Y
V
H
-----------------
C
S
----
D
--------------------
E
--
A
----------------------------------
A
V
-------------------------
A
Q
E
A
V
S
L
V
A
T
G
Q
A
-
Q
I
L
-----
L
K
G
I-
I
--
Q
T
H
T
L
L
K
E
M
-----
L
K
S
E
H
Q
L
K
------
N
K
P
---
I
------
L
S
H
V
A
M
V
E
L
P
-
A
-----
G
K
T
F
L
L
T
D
C
A
----
M
-
N
-------
I
A
P
T
-------
Q
A
T
L
------
I
E
I
V
E
------
N
A
------
K
E
V
A
Q
K
-
L
G
L
H
H
-----
P
K
I
A
L
-----
L
S
----
A
A
E
------------------------
N
F
N
---
P
K
M
P
S
S
V
---
L
---
A
-
K
E
-----
V
T
A
H
F
N
--
D
-----------------
Q
Q
-
E
A
T
V
---
F
G
PL
S
L
D
L
A
T
S
--------------------------------
E
E
A
V
A
--------
H
K
R
----------------
Y
S
-
G
P
I
M
G
D
A
D
I
L
V
V
P
T
I
D
V
G
N
C
L
Y
K
S
L
---
T
L
F
G
H
A
K
V
-
G
G
T
I
V
G
T
K
----
V
P
V
V
L
T
S
R
S
D
S
T
E
S
K
F
H
S
L
R
F
A
M
R
Q
V
H
--
H
H
-----------------------------------------------
37
Fugue
57.71
16%
-53
- C5 -
4U1D
-
EIF3A_YEAST
A:
[9-496]
FR
P
E
N
A
I
K
R
A
D
E
L
I
S
V
GE
K
Q
A
A
L
Q
S
L
H
D
F
I
T
ARRIRWATPSTV
E
P
V
V
F
K
F
L
E
I
G
V
E
L
-
K
K
G
K
L
L
K
D
G
L
--------
H
Q
Y
K
K
L
I
Q
G
-
S
T
--
E
-
G
L
V
S
V
G
A
-------
V
A
R
K
F
I
--
D
-
L
V
E
S
K
I
-----------------
A
S
----
E
--------------------
Q
--
T
R
A
-------------
D
--------------
E
L
Q
K
Q
E
I
-------------
D
A
I
-
T
S
--
W
--
L
R
F
T
W
E
S
Y
R
A
V
-
L
-
D
L
L
RNNAL
L
E
I
--
T
--
Y
S
G
V
V
K
K
T
M
-----
H
F
C
L
K
Y
Q
R
------
K
N
E
---
F
------
K
R
L
A
E
M
L
R
Q
H
-
L
-----
D
A
A
N
Y
Q
Q
S
K
S
----
G
-
N
NLVDLSD
A
D
T
L
-------
Q
R
Y
L
D
Q
R
F
Q
Q
V
D
V
S
V
K
L
EL
W
H
E
A
------
Y
R
S
I
E
D
V
F
H
L
M
K
I
SKRA
P
K
P
S
T
-----
L
A
----
N
Y
Y
------------------------
E
N
L
---
V
K
---
V
F
---
F
---
V
-
S
G
D
P
L
L
H
T
T
A
W
K
K
--
F
Y
--
K
------
L
Y
-
S
T
N
P
R
A
T
E
E
E
F
---
K
T
--
Y
S
S
T
I
F
L
--
S
A
I
S
TQLDE
I
P
S
I
GYDPH
L
R
M
Y
R
L
L
N
L
D
A
K
P
T
R
K
E
M
L
Q
S
--
I
I
E
D
E
SIYGKVD
E
E
L
K
E
L
Y
D
I
I
E
V
N
F
D
V
D
T
V
K
Q
Q
L
E
N
L
L
------
V
K
L
S
---
S
K
T
Y
F
S
Q
Y
I
A
P
L
R
D
V
I
M
----
R
R
V
F
V
A
A
S
Q
K
F
T
T
V
S
Q
S
E
L
Y
K
L
A
T
L
P
A
PL
D
L
S
A
W
D
I
E
K
S
L
L
Q
A
A
V
E
D
Y
V
S
I
T
I
D
H
E
S
A
K
V
T
F
A
K--------------
33
Fugue
56.71
11%
-45
* C4 *
1F0K
-
MURG_ECOLI
A:
[7-357]
--------------------------------------------------
K
R
L
M
V
M
A
G
G
T
G
G
H
V
F
P
G
L
--------
A
-
V
A
H
H
L
M
A
-
Q
G
--
W
-
Q
V
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
--
I
-
E
I
D
F
I
R
-----------------
I
S
----
G
--------------------
L
RG
K
G
I
-------------
K
--------------
A
L
I
A
A
P
L
-------------
R
I
F
-
N
A
--
W
--
R
Q
A
R
A
I
M
K
A
Y
K
-
P
-
D
V
V
-----
L
G
M
--
G
--
G
Y
V
S
G
P
G
G
L
-----
A
A
W
S
L
G
I
P
------
V
V
L
---
H
E
QNGIA
G
L
T
N
K
W
L
A
K
I
-
A
-----
T
K
V
M
Q
A
F
P
G
A
----
F
-
P
-------
N
A
E
V
-------
V
G
N
P
------
V
R
T
D
V
------
L
A
------
L
P
L
P
Q
Q
R
L
A
G
R
E
-----
G
P
V
R
V
-----
L
V
----
V
G
G
------------------------
S
Q
----
G
A
---
R
I
---
L
---
N
-
Q
T
-----
M
P
Q
V
A
A
--
K
L
GD
S
------
V
T
-
I
W
H
Q
S
G
-
K
G
S
Q
---
Q
S
--
V
E
Q
A
Y
A
E
--
A
G
------------------
Q
P
Q
H
K
V
T
E
F
I
D
D
M
A
A
A
Y
A
W
AD
V
V
V
C
R
----------------
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
------
V
P
F
Q
---
H
K
D
R
Q
Q
Y
W
N
A
L
P
L
E
K
A
G
----
A
A
K
I
I
E
Q
P
Q
L
S
V
D
A
V
A
N
T
L
A
---
G
W
S
R
--
E
T
L
L
T
M
A
E
R
A
R
A
A
S
I
P
D
A
T
E
R
V
A
N
E
V
S
R
V
A
R
AL----------------
15
HHSearch
52.33
18%
11
- C3 -
1R5J
-
?
A:
[25-328]
----------------------------------------------------------
E
G
N
-
D
E
-
R
V
V
--------
R
A
A
A
R
L
K
F
E
--
G
--
L
L
E
P
I
I
L
G
Q
S
E
E
V
R
N
L
L
T
K
L
G
F
AD
Q
-
D
Y
T
I
I
N
-----------------
P
N
----
E
--------------------
Y
--
A
D
F
----------------------------
D
K
M
K
E
A
F
V
E
V
RKGKAT
L
E
D
A
D
K
M
L
R
D
--
V
--
N
Y
F
G
V
M
L
V
K
M
G
L
A
-
D
G
M
-----
V
S
G
--
A
IH
S
T
A
D
T
V
R
P
A
-----
L
Q
I
I
K
T
K
P
------
G
I
S
---
R
------
T
S
G
V
F
L
M
N
R
E
-
N
T----
S
E
R
Y
V
F
A
D
C
A
----
I
-
N
-------
I
D
P
T
-------
A
Q
E
L
------
A
E
I
A
V
------
N
T
------
A
E
T
A
K
-
I
F
D
I
-
D
-----
P
K
I
A
M
-----
L
S
----
F
S
T
------------------------
K
G
S
---
G
K
A
P
Q
V
D
---
K
---
V
-
R
E
-----
A
T
E
I
A
T
--
G
L
----------------
N
P
-
D
L
A
L
---
D
G
EL
Q
F
D
A
A
F
V
--------------------------------
P
E
T
A
A
--------
I
K
A
----------------
P
-
D
S
A
V
A
G
Q
A
N
T
F
V
F
P
D
L
Q
S
G
N
I
G
Y
K
I
A
---
Q
R
L
G
M
F
D
A
I
G
P
I
L
Q
G
L
N
----
K
P
V
N
D
L
S
R
G
S
S
A
E
D
I
Y
K
L
A
I
I
T
A
A
Q
A
I
--
E
S
-----------------------------------------------
35
Fugue
51.16
14%
-37
- C5 -
2VDW
-
MCES_VACCW
B:
[1-287]
-----------------------------------------------------------
M
D
E
I
V
K
N
I
R
--------
E
G
------------
T
-
H
V
L
L
P
F
Y
E
T
L
P
E
L
N
L
S
L
G
K
S
--
P
-
L
P
S
L
E
Y
-----------------
G
A
----
N
--------------------
Y
--
F
L
Q
-------------
I
--------------
S
R
V
N
D
L
N
-------------
R
M
P
-
T
D
--
M
--
L
K
L
F
T
H
D
I
M
L
P
-
E
-
S
D
L
-----
D
K
V
--
Y
--
E
I
---
L
K
I
N
-----
S
V
K
-
Y
Y
G
R
------
S
T
K
---
A
------
D
A
V
V
A
D
L
-
S
A
-
R
-----
N
K
L
F
K
R
E
R
D
A
----
I
-
K
-------
S
T
E
N
-------
N
L
Y
I
------
S
D
Y
K
M
------
L
T
------
F
D
V
F
R
P
L
F
D
F
V
N
-----
E
K
Y
C
I
-----
I
K
----
L
-------------------------------------
P
T
---
L
---
F
G
R
G
-----
V
I
D
T
M
R
--
I
Y
--
C
------
S
L
-
F
K
N
V
R
----
L
L
---
K
C
--
V
S
D
-------
S
------------------
W
L
K
D
S
A
I
M
V
A
S
D
V
C
K
K
N
L
D
--
L
F
M
S
H
----------------
V
K
S
V
T
K
S
S
S
W
K
D
V
N
S
V
Q
F
------
S
I
L
N
---
N
P
V
D
----------------------
T
E
F
I
N
K
F
L
E
F
S
N
R
V
Y
E
A
L
Y
Y
V
H
--
S
L
L
Y
S
S
M
T
S
D
S
K
S
I
E
N
K
H
Q
R
R
L
V
K
L
L
L
----------------------
36
Fugue
51.11
10%
-46
- C4 -
1K5H
-
DXR_ECOLI
A:
[1-398]
-------------------------------------M
K
Q
L
T
I
L
GSTG
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
H
F
R
V
V
A
L
V
A
G
KN
V
T
R
M
V
E
Q
C
L
E
-
F
S
--
P
-
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
K
T
M
L
Q
Q
--
Q
-
G
S
R
T
-------------------------
E
--------------------
V
--
L
S
G
-------------
Q
--------------
Q
A
A
C
D
M
A
-------------
A
L
E
-
D
V
--
D
--
Q
V
M
A
A
I
V
G
A
A
G
-
L
-
L
P
T
-----
L
A
A
--
I
--
R
A
G
K
T
I
L
L
A
NK
E
S
L
V
T
C
G
R
L
F
M
------
D
A
V
---
K
------
Q
S
K
A
Q
L
L
P
-
V
-
D
-----
S
E
H
N
A
I
F
Q
S
L
----
P
-
Q
-------
P
I
Q
H
N
LGYADL
E
Q
N
G
------
V
V
S
I
L
------
L
T
G
S
G
GPF
R
E
T
P
L
R
D
L
A
T
M
T
-----
P
D
Q
A
C
RHPN
W
S
M
----
G
R
K
------------------------
I
S
V
---
D
S
---
A
T
---
M
---
M
-
N
K
-----
G
L
E
Y
I
E
--
A
R
--
W
------
L
F
-
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
--
V
I
H
S
M
V
R
Y
Q
D
G
------------------
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
--
A
W
P
N
R
----------------
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
------
A
A
P
D
---
Y
D
R
Y
P
C
L
K
L
A
M
E
A
F
E
Q
G
----
Q
A
A
T
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
----
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
L
A
S----
31
Fugue
50.88
11%
-38
- C4 -
1F0K
-
MURG_ECOLI
A:
[7-357]
--------------------------------------------------
K
R
L
M
V
M
A
G
G
T
G
G
H
V
F
P
G
L
---------
A
V
A
H
H
L
M
A
-
Q
G
--
W
-
Q
V
R
W
L
G
T
A
D
R
M
E
A
D
L
V
P
K
H
G
--
I
-
E
I
D
F
I
R
-----------------
I
S
----
G
--------------------
L
--
R
G
K
-------------
G
--------------
I
K
A
L
I
A
A
-------------
P
L
R
-
I
F
--
N
--
A
W
R
Q
A
R
A
I
M
K
A
-
Y
-
K
P
D
-----
V
V
L
--
G
--
M
G
G
-
Y
V
S
G
P
-----
G
G
L
A
A
W
S
L
------
G
I
P
---
V
------
V
L
H
E
Q
N
G
I
A
G
-----------------------------------------------------------------------
L
T
N
K
W
L
A
K
----------------------------
I
AT
K
V
M
Q
AFPGAFPNAEVV
G
N
P
V
R
T
D
V
---
L
A
---
L
P
---
L
------------
P
Q
Q
R
L
A
--
G
R
--
E
G
P
V
R
V
L
V
V
-
G
G
S
Q
G
A
-
R
I
L
N
---
Q
T
--
M
P
Q
V
A
A
K
--
L
G
------------------
D
S
V
T
I
W
H
Q
S
G
K
G
S
Q
Q
S
V
E
Q
--
A
Y
A
E
A
GQPQ
H
-----------
K
V
T
E
F
I
D
D
M
A
A
A
Y
A
W
A
D
V
------
V
V
C
R
S
G
A
L
T
V
S
E
I
A
A
A
G
L
P
A
L
F
V
P
----
F
Q
H
K
D
R
Q
Q
Y
W
N
A
L
P
L
E
K
A
G
A
A
K
I
I
E
Q
P
--
Q
L
S
V
D
A
V
A
N
T
L
A
G
W
S
R
E
T
L
L
T
M
A
E
R
A
R
A
A
SIPD
A
T
E
R
V
A
N
E
V
S
R
V
A
R
AL
4
PsiBlast_PDB
48.35
28%
-45
- C3 -
1GUD
2
ALSB_ECOLI
A:
[125-226]
-----------------------------------------------------
I
I
D
K
L
G
A
E
G
G
E
V
A
I
I
--------
E
G
--------
K
A
--
G
-
N
A
S
G
E
A
R
R
N
G
A
T
E
A
F
K
K
--
A
--
S
-
Q
I
K
L
V
A
-----------------
S
Q
P
ADW
D
--------------------
R
--
I
K
A
-------------
L
--------------
D
V
A
T
N
V
L
-------------
Q
R
N
-
P
N
IK
A
--
I
Y
C
A
N
D
T
M
A
M
G
V
A
-
Q
A
V
-----
A
N
A
--
G
--
K
T
G
K
V
L
V
V
G
-----
T
D
G
I
P
E
A
R
------
K
M
V
---
E
------
A
G
Q
M
T
A
T
V
A
Q
-
N
-----
P
A
D
I
G
A
T
G
L
K
----
L
-
M
-------
V
D
A
E
-------
K
S
G
K
------
V
I
P
L
D
------
K
A
------
P
E
F
K
L
V
D
S
I
L
V
T
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.33
28%
-48
- C3 -
1RPJ
2
ALSB_ECOLI
A:
[125-226]
-----------------------------------------------------
I
I
D
K
L
G
A
E
G
G
E
V
A
I
I
--------
E
G
--------
K
A
--
G
-
N
A
S
G
E
A
R
R
N
G
A
T
E
A
F
K
K
--
A
--
S
-
Q
I
K
L
V
A
-----------------
S
Q
P
ADW
D
--------------------
R
--
I
K
A
-------------
L
--------------
D
V
A
T
N
V
L
-------------
Q
R
N
-
P
N
IK
A
--
I
Y
C
A
N
D
T
M
A
M
G
V
A
-
Q
A
V
-----
A
N
A
--
G
--
K
T
G
K
V
L
V
V
G
-----
T
D
G
I
P
E
A
R
------
K
M
V
---
E
------
A
G
Q
M
T
A
T
V
A
Q
-
N
-----
P
A
D
I
G
A
T
G
L
K
----
L
-
M
-------
V
D
A
E
-------
K
S
G
K
------
V
I
P
L
D
------
K
A
------
P
E
F
K
L
V
D
S
I
L
V
T
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.10
28%
-52
- C3 -
1GUB
-
ALSB_ECOLI
A:
[125-226]
-----------------------------------------------------
I
I
D
K
L
G
A
E
G
G
E
V
A
I
I
--------
E
G
--------
K
A
--
G
-
N
A
S
G
E
A
R
R
N
G
A
T
E
A
F
K
K
--
A
--
S
-
Q
I
K
L
V
A
-----------------
S
Q
P
A
D
W
D
--------------------
R
--
I
K
A
-------------
L
--------------
D
V
A
T
N
V
L
-------------
Q
R
N
-
P
N
IK
A
--
I
Y
C
A
N
D
T
M
A
M
G
V
A
-
Q
A
V
-----
A
N
A
--
G
--
K
T
G
K
V
L
V
V
G
-----
T
D
G
I
P
E
A
R
------
K
M
V
---
E
------
A
G
Q
M
T
A
T
V
A
Q
-
N
-----
P
A
D
I
G
A
T
G
L
K
----
L
-
M
-------
V
D
A
E
-------
K
S
G
K
------
V
I
P
L
D
------
K
A
------
P
E
F
K
L
V
D
S
I
L
V
T
-----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
44.58
26%
-44
* C5 *
4TYZ
1
?
A:
[1-109]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
E
G
V
-----
F
R
----
K
S
F
------------------------
P
D
L
---
A
G
---
E
T
---
L
---
L
-----------------
D
--
S
------
F
N
-
C
A
W
V
E
G
-
S
A
L
K
---
Q
G
--
Y
L
F
I
T
P
-------------------------
H
W
L
C
F
Q
S
T
--
L
A
A
A
H
F
S
--
I
E
Y
D
E
----------------
I
K
D
I
I
K
S
K
S
V
K
-
M
F
E
N
A
I
------
E
V
K
T
---
H
--------------
L
N
----
D
T
I
F
L
T
N
F
L
Q
R
D
Q
A
Y
S
A
L
M
S
Q
W
L
K
------------------------------------------------------
20
HHSearch
43.26
10%
-58
- C3 -
1YXO
7
PDXA1_PSEAE
A:
[16-234]
--------------------------------------------------------------
G
P
D
L
C
L
--------
L
L
A
R
S
A
Q
----
P
--
H
-
P
L
I
A
I
A
S
R
T
L
L
Q
E
R
A
G
Q
L
G
L
A
-
I
-
D
L
K
D
V
S
-----------------
P
A
----
A
WPERPAKAG
Q
L
Y
V
W
D
T
P
L
A
A
P
--
V
R
P
-------------
G
--------------
Q
L
D
R
A
N
--------------
A
A
Y
V
L
E
--
T
--
L
T
R
A
G
Q
G
C
L
D
G
H
F
-
A
G
M
-----
I
T
A
P
-
V
--
H
K
G
V
I
N
E
A
G
-----
I
P
F
S
G
H
T
E
F
L
A
D
L
T
H
T
A
---
Q
------
V
--
V
M
M
L
A
T
R
-
G
-----
L
R
V
A
L
A
T
T
H
L
PLRE
V
-
A
-------
D
A
I
S
-------
D
E
R
L
------
T
R
V
A
R
------
I
L
------
H
A
D
L
R
D
K
F
G
I
A
H
-----
P
R
I
L
V
-----
C
G
LNPH
A
G
E
------------------------
G
G
H
---
L
G
---
R
E
---
E
IEV
I
-
E
P
-----
C
L
E
R
L
R
--
G
E
--
G
------
L
D
-
L
I
G
P
L
P
-
A
D
T
L
---
F
T
--
P
K
H
L
E
H
C
--
D
A
------------------
V
L
A
M
Y
H
D
Q
G
L
P
V
L
K
Y
K
G
F
G
--
A
A
V
N
V
----------------
T
L
G
L
P
I
I
R
T
S
V
D
H
G
T
A
L
D
------
L
A
G
S
---
G
R
I
D
S
G
S
L
Q
V
A
L
E
T
A
Y
Q
----
M
A
A
S
R
C
------------------------------------------------------------------------
19
HHSearch
42.12
11%
-52
- C3 -
3LXY
3
PDXA_YERPE
A:
[22-239]
--------------------------------------------------------------
G
P
D
L
A
I
--------
T
L
A
Q
Q
D
W
----
P
--
V
-
E
L
V
V
C
A
D
P
A
L
L
L
A
R
A
S
Q
L
N
L
--
P
L
Q
L
R
E
Y
Q
ADQPAIAQQAG
S
L
T
I
L
P
V
K
T
A--
V
--------------------
N
--
V
V
P
-------------
G
K-------------
L
D
V
G
-
N
--------------
S
H
Y
V
V
E
--
T
--
L
A
K
A
C
D
G
A
I
S
G
E
F
-
A
A
L
-----
V
T
G
P
-
V
--
Q
K
S
I
I
N
D
A
G
-----
I
P
F
I
G
H
T
E
F
F
A
D
R
S
H
C
Q
---
R
------
V
--
V
M
M
L
A
T
E
-
E
-----
L
R
V
A
L
A
T
T
H
L
PLLA
V
-
P
-------
G
A
I
T
-------
Q
A
S
L
------
H
E
V
I
T
------
I
L
------
D
N
D
L
K
T
K
F
G
I
T
Q
-----
P
Q
I
Y
V
-----
C
G
LNPH
A
G
E
------------------------
G
G
H
---
M
G
---
H
E
EID
T
---
I
-
I
P
-----
A
L
N
T
L
R
--
Q
Q
--
G
------
I
N
-
L
I
G
P
L
P
-
A
D
T
L
---
F
Q
--
P
K
Y
L
Q
H
A
--
D
A
------------------
V
L
A
M
Y
H
D
Q
G
L
P
V
L
K
Y
Q
G
F
G
--
R
A
V
N
I
----------------
T
L
G
L
P
F
I
R
T
S
V
D
H
G
T
A
L
E
------
L
A
A
T
---
G
T
A
D
V
G
S
F
I
T
A
L
N
L
A
I
K
----
M
I
N
N
S
-------------------------------------------------------------------------