@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0191: (2015-12-13 )
MDLRIQSKEVSHNLKELSKTLISYPFEKHVEALGEQCSNFVSIPINNDDYSNICTFVSDFINLIASYNLLESFLDFYKDKLKLSELVTEYANVTNNLLFKKLIKHLSGNNQLVKNFYQCIREIIKYNAPNKEYKPNQFFIIGKGKQKQLAKIYSHLKELSASEIKPQDMEDILKKLEELDKIFKTTDFTKFTPKTEIKDIIKEIDEKYPINENFKRQFNEFESNIEKHDEIKKDFERNKESLIREIENHCKNECNSEEEPEYKINDLLKNIQQICKNYIESHAVNDVSKDIKSMMCQFYLKQIDLLVNSEIVRYRYSNLFEPIQRSLWESIKILDNESGIYLFPKNIGEIKDKFEANKEKFKQSKNVSEFAEYCRECNPYTAFNFHLNINNGLSHQFEKFVPIMKEYKEPKITDNDLEAISTKETGLASQLSGHWFFQLSLFNKTNFNPNKIWIPLEFNKRSKIKFDKDLEIYFDSHESFNISKKYLQEIDQESLKKIKQSKDFFSIQKIESKHDNNDILQLEFFENDTSFLFAKGSFAEILEYNMQLKIDSLITKEFNKLLAIVQDSPQDSYQLKIRVRHNNKLPREKYTEHEIKLEVYDCRKSHDHNEPIILSQQSTGFQWAFNFMFGFLYNVGSHFSFNHNIIYVMDEPATHLSVPARKEFRKFLKEYAHKNHVTFVLATHDPFLVDTDHLDEIRIVEKETEGSVIKNHFNYPLNNASKDSDALDKIKRSLGVGQHVFHNPQKHRIIFVEGITDYCYLSAFKLYLRYKEYKDNPIPFTFLPISGLKNDSNDMKETIEKLCELDNHPIVLTDDDRKCVFNQQATSERFKRANEEMHDPITILQLSDCDRHFKQIEDCFSANDRNKYAKNKQMELSMAFKTRLLYGGEDAIEKQTKRNFLKLFKWIAWATNLIKN
Atome Classification :
(20 SA)
.........10-........20........30........40........50........60........70........80.......-.90........100.......110.......120.......130........140.......150.......160.......170.......180.......190.......200.......210.......-220.......230.......240.......250.......260.......270.......280.......290.......-300.......-310.......320.......330.......340.......350.......360.....-..370.......380.......390..----.....400...-.....410.......420.......430.......440.......450.......460......-.470.......480.......490--.......500.......510....-----...520.......530.....-..540.......550--.---..---....560.......570.......580.....--..--590---------.-----------........600.......----610--.----.----.----.----.....620........630.....-.--.640-.......--650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.-......840.......850.......860.......870.......880.......890.......900.......910....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDLRI
Q
S
K
E
V
S
-
H
N
L
K
E
L
S
K
T
L
ISY
P
F
E
K
H
V
E
A
L
G
E
Q
C
S
N
F
V
SIPINND
D
Y
S
N
I
C
T
F
V
S
D
F
I
N
L
I
A
S
Y
N
L
L
E
S
F
L
D
F
Y
K
D
K
L
K
L
S
E
L
V
T
-
E
Y
A
N
V
T
N
N
L
L
F
K
K
L
I
K
H
LSGN
N
Q
L
V
K
N
F
Y
Q
C
I
R
E
I
I
KYNAPN-KEYKPN
Q
F
F
I
I
GKG
K
Q
K
Q
L
A
K
I
Y
S
H
L
K
E
L
S
ASEIK
P
Q
D
M
E
D
I
L
K
K
L
E
E
L
D
K
I
F
KTTDFTKFTP
K
T
E
I
K
D
I
I
K
E
I
D
E
KYPI
N
E
N
F
K
R
Q
F
N
-
E
F
E
S
N
I
E
K
H
D
E
I
K
K
D
F
E
R
N
K
E
S
L
I
R
E
I
E
N
H
C
KNECNSEEEPE
Y
K
I
N
D
L
L
K
N
I
Q
Q
I
C
K
N
Y
I
E
S
HA
V
N
D
V
S
K
D
I
K
S
M
M
C
Q
F
Y
-
L
K
Q
I
D
L
L
VN
S
-
E
I
V
R
Y
R
Y
S
N
L
F
E
P
I
Q
R
S
L
W
E
S
I
K
ILDNES
G
I
Y
L
FPK
N
I
G
E
I
K
D
K
F
E
A
N
K
E
K
F
K
QSK
N
V
-
S
E
F
A
E
Y
C
RECNPY
T
A
F
N
F
H
L
N
INNG
L
S
----
H
Q
F
E
K
F
V
-
P
I
M
-
K
E
YKEPKITDN
D
L
E
A
ISTKET
G
L
A
S
QLSG
H
W
F
F
Q
L
S
LFNKTNFNP
N
K
I
W
I
PLEFNKRSK
I
K
FDK-D
L
E
I
Y
FDSHESFN
I
S
K
K
Y
L
Q
E
I
D
Q
--
E
S
L
K
K
I
K
QSKD
F
F
S
I
Q
K
I
ESKHDN-----N
D
I
L
Q
L
E
F
FENDT
S
F
L
F
AKG
S
-
F
A
E
I
L
E
Y
N
M
Q
L
K
I
D
S
--
L
---
I
T
---
K
E
F
N
K
L
L
A
I
V
QDSPQD
S
Y
Q
L
K
I
R
V
R
HNNKL
P
R
--
E
K--Y-----------T-----------E
H
E
I
K
L
E
V
Y
D
CRKSHDHN----E----
P
----
I
----
I
----
L
----SQQSTG
F
-
Q
W
A
F
N
F
M
F
G
F
L
Y
NVGS-H--FSFN-H
N
I
I
Y
V
M--DEPATHLS
V
P
A
R
K
E
F
R
K
F
L
K
E
Y
AHKN
H
V
T
F
V
L
ATHD
P
F
L
VDTDHLD
E
I
R
I
V
E
KETEG
S
V
I
K
N
HFNYPLNNASK
D
S
D
A
L
D
K
I
K
R
S
LGV
G
Q
H
VFHNPQ
K
H
R
I
I
F
V
EGI
T
D
Y
C
Y
L
S
A
F
K
L
Y
L
R
Y
K
EYKDNPI
P
F
T
F
LPISGLKND
S
N
D
M
K
E
T
I
E
K
L
CELDNH
P
I
V
L
TDDDR
K
C
V
FN
Q
Q
A
T
S
E
R
F
K
R
A-NEEMHD
P
I
T
I
L
QL
S
D
C
D
R
H
F
K
Q
I
E
D
C
FSAND
R
N
KYAKNK
Q
M
E
L
S
M
A
F
K
T
R
L
LYGG
E
D
A
I
E
K
Q
T
K
R
N
F
L
K
L
F
K
W
I
A
W
A
T
N
LIKN
42
HHSearch
65.52
20%
-46
- C4 -
3GFO
1
ECFA3_CLOP1
A:
[43-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
--
P
S
-
S
G
R
I
L
F
D
--
N
K
P
I
D
Y
S
R
K
---
G
I
---
M
K
L
R
E
S
I
G
I
V
F
Q
D
P
D
-
N
Q
L
F
S
A
S
V
Y
Q
D
V
S
F
G
A
--
V
N
--
M
-----------
K
LP
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
G
I
E
H
L
-----------
K
----
D
----
K
----
P
----
T
----
H
C
L
S
F
G
Q
-
K
K
R
V
A
I
A
G
V
L
V
M
-------------
E
P
K
V
L
I
L
--
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
-
L
Y
C
D
N
V
F
V
M
K
E
---
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
K
V
N
L
R
L
P
R
I
G
H
L
M
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
54.62
12%
-12
- C3 -
2Y3U
2
?
A:
[15-695]
---
N
L
Y
F
Q
G
G
T
M
Y
D
F
E
Y
L
N
G
L
----
S
Y
T
E
L
T
N
L
I
K
---------
N
I
K
W
N
Q
I
N
G
L
F
N
Y
S
T
G
S
Q
K
F
F
G
D
K
N
R
V
Q
A
I
I
N
A
L
Q
E
S
G
R
T
Y
T
A
N
D
M
K
G
I
E
T
F
T
E
V
L
R
A
G
F
--
Y
L
G
Y
Y
N
D
G
L
S
Y
L
N
D
--
R
N
F
Q
D
K
C
I
P
A
M
I
A
I
Q
K
N
P
N
F
K
L
G
T
A
V
Q
D
E
V
I
T
S
L
G
K
L
--
I
G
N
A
S
A
N
A
E
V
V
N
N
C
V
P
V
L
K
Q
F
R
E
N
L
N
Q
Y
-
A
P
D
Y
V
K
G
T
A
V
N
E
L
I
K
G
I
E
F
D
F
S
G
A
A
Y
E
K
D
V
K
T
M
P
W
Y
G
K
I
--------------
D
P
F
I
N
E
L
K
A
L
G
L
Y
G
-
N
I
T
S
A
T
E
W
A
S
D
V
G
I
Y
Y
L
S
K
F
G
L
Y
S
------
T
N
R
N
D
I
V
Q
S
L
E
K
A
V
D
M
Y
K
Y
G
K
I
A
F
V
A
M
E
R
I
T
W
D
Y
D
G
---
I
G
S
N
G
K
K
V
D
H
D
K
F
L
D
D
A
E
K
H
Y
L
P
-----
K
T
Y
T
F
D
N
G
T
F
I
I
R
A
G
D
K
V
S
E
E
K
I
K
R
L
Y
W
A
S
R
E
V
K
S
Q
F
H
R
V
V
G
N
D
K
A
LEVG
N
A
D
D
V
L
T
M
K
I
F
-
N
S
P
E
E
Y
K
-
F
N
T
N
I
N
G
V
S
T
D
N
G
G
L
Y
I
E
P
R
G
T
F
Y
T
Y
---------------------
E
R
T
P
Q
Q
S
I
F
-
S
L
E
E
L
F
R
H
E
Y
T
H
Y
L
Q
A
R
Y
L
---------
V
D
G
L
W
G
Q
G
P
F
Y
E
K
N
R
-----------------
L
T
W
F
D
E
G
T
A
E
F
F
A
G
S
T
---------------------------------------------------
R
T
S
G
V
L
P
R
-------------------------------
K
L
I
L
G
Y
L
A
K
D
K
V
D
H
R
Y
S
----
L
----
K
----
K
----
T
----
L
----
N
S
D
D
S
D
W
M
F
Y
N
Y
G
F
A
V
A
H
Y
L
Y
E
K
D
M
P
--
T
F
I
K
M
N
K
A
I
L
N
T
--
D
----------
V
K
S
Y
D
E
I
I
K
K
L
S
D
D
A
N
K
N
T
E
Y
Q
N
H
I
Q
E
L
V
D
K
Y
Q
G
A
G
I
P
L
V
S
D
D
Y
L
K
D
----------
H
G
Y
K
K
A
S
E
V
Y
S
E
I
S
K
A
A
S
L
T
N
T
S
V
T
A
E
K
S
Q
------------
Y
F
N
T
F
T
L
R
G
T
Y
T
G
E
T
S
-------------
K
G
E
F
K
D
W
D
------------------------------------
E
M
S
K
K
L
D
G
T
L
E
S
L
A
----
K
N
S
W
S
G
Y
K
T
L
T
A
Y
F
T
N
Y
R
V
T
S
D
N
K
V
Q
Y
D
V
V
F
H
G
V
L
T
D
N
G
----------------------------
45
HHSearch
53.43
18%
-28
- C4 -
1YQT
2
?
A:
[311-477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
--
E
P
T
-
E
G
K
I
E
W
D
-----------------------
L
T
V
A
Y
K
P
Q
Y
I
--
K
A
D
Y
E
G
T
V
Y
E
L
L
S
K
I
D
--
A
S
--
K
-----------
L
N
S
N
F
Y
K
T
----
E
L
L
K
P
L
G
I
I
D
L
-----------
Y
----
D
----
R
----
E
----
V
----
N
E
L
S
G
G
E
-
L
Q
R
V
A
I
A
A
T
L
L
R
-------------
D
A
D
I
Y
L
L
--
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
-
Y
V
S
D
R
L
M
V
F
E
G
E
P
G
K
Y
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
I
G
I
T
F
R
R
D
P
D
T
G
R
P
R
A
N
K
E
G
S
V
K
D
R
E
Q
K
E
K
G
E
Y
Y
Y
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
52.77
19%
-42
- C4 -
3BK7
1
?
A:
[391-547]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
--
P
T
-
E
G
K
V
E
W
D
-----------------------
L
T
V
A
Y
K
P
Q
Y
I
--
K
A
E
Y
E
G
T
V
Y
E
L
L
S
K
I
D
--
S
S
--
K
L
N
S
N
F
Y
K
----
T
-----------
E
L
L
K
P
L
G
I
I
D
L
-----------
Y
----
D
----
R
----
N
----
V
----
E
D
L
S
G
G
E
-
L
Q
R
V
A
I
A
A
T
L
L
R
-------------
D
A
D
I
Y
L
L
--
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
-
V
S
D
R
L
I
V
F
E
G
E
P
G
R
H
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
V
G
I
T
F
R
R
D
P
D
S
G
R
P
R
A
N
K
E
G
S
V
K
D
R
E
Q
K
A
R
G
E
Y
Y
Y
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
50.69
16%
-36
- C4 -
2YYZ
3
?
A:
[28-214]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
E
F
V
A
LLGP
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
--
P
T
-
S
G
E
I
Y
F
D
--
D
V
L
V
N
D
--
I
---
P
P
-----
K
Y
R
E
V
G
M
V
F
Q
N
Y
--
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
P
L
--
R
A
--
R
-----------
R
ISKD
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
N
L
L
---------------
D
----
R
----
K
----
P
----
T
Q
L
S
G
G
Q
-
Q
Q
R
V
A
L
A
R
A
L
V
K
-------------
Q
P
K
V
L
L
F
--
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
-
T
M
A
S
R
I
A
V
F
N
Q
---
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
D
S
P
K
N
M
F
V
A
S
F
I
G
N
P
P
T
N
F
L
R
D
F
S
V
S
V
E
N
K
Q
T
I
L
K
R
D
D
V
I
I
K
L
P
E
P
V
D
V
K
L
K
E
V
V
V
G
I
R
P
E
H
C
R
I
S
R
E
R
V
E
N
S
I
P
G
V
V
Y
V
V
E
P
L
G
R
D
I
I
V
N
V
K
T
E
K
G
E
I
I
K
V
F
G
D
T
G
K
A
P
Q
P
G
E
N
-
V
F
L
V
P
D
L
R
K
I
H
L
F
N
P
E
T
E
E
T
I
L
-------------------------------------------------------------
31
HHSearch
50.51
20%
-28
- C4 -
3D31
-
?
A:
[25-208]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
--
V
P
D
-
S
G
R
I
L
L
D
--
G
K
D
V
T
D
--
L
---
S
P
-----
E
K
H
D
I
A
F
V
Y
Q
N
Y
--
S
L
F
P
H
M
N
V
K
K
N
L
E
F
G
M
--
R
M
--
K
-----------
K
IKD
P
K
R
V
L
---
D
T
A
R
D
L
K
I
E
H
L
L
---------------
D
----
R
----
N
----
P
----
L
T
L
S
G
G
E
-
Q
Q
R
V
A
L
A
R
A
L
V
T
-------------
N
P
K
I
L
L
L
--
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
R
-
I
M
A
D
R
I
A
V
V
M
D
---
G
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
A
S
F
V
G
F
E
N
V
L
K
G
R
V
I
S
A
E
Q
G
L
L
R
I
R
V
G
E
V
V
I
D
A
A
G
D
M
E
V
G
D
Q
V
Y
A
F
L
R
P
E
N
I
A
L
S
K
S
S
T
Q
S
S
I
R
N
S
L
Q
G
R
V
T
E
A
W
V
L
G
A
L
V
R
V
K
V
D
C
G
V
P
L
N
V
L
I
T
R
R
S
A
E
E
M
E
L
S
P
-
G
V
Q
I
Y
A
R
F
K
A
S
S
V
H
V
L
R
------------------------------------------------------------------
43
HHSearch
50.22
13%
-7
- C4 -
2IXE
3
TAP1_RAT
A:
[44-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
--
P
T
-
G
G
K
V
L
L
D
--
G
E
P
L
V
Q
--
Y
---
D
H
---
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
---
L
L
F
G
R
S
F
R
E
N
I
A
Y
G
L
--
T
R
--
T
-----------
P
T
M
E
E
I
T
-----
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
YDTE
V
----
G
----
E
----
T
----
G
----
N
Q
L
S
G
G
Q
-
R
Q
A
V
A
L
A
R
A
L
I
R
-------------
K
P
R
L
L
I
L
--
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
P
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
--
R
A
H
H
I
L
F
L
K
E
---
G
S
V
C
E
Q
G
T
H
L
Q
L
M
E
R
G
G
C
Y
R
S
M
V
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
49.10
18%
-26
- C4 -
3B60
2
MSBA_SALTY
A:
[378-558]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
--
Y
D
I
D
-
E
G
H
I
L
M
D
--
G
H
D
L
R
E
--
Y
---
T
L
---
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
---
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
--
T
E
EY
S
R
E
Q
I
-------
E
-----------
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
----
L
----
D
----
T
----
I
I
G
EN
G
----
V
L
L
S
G
G
Q
-
R
Q
R
I
A
I
A
R
A
L
L
R
-------------
D
S
P
I
L
I
L
--
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
--
Q
A
D
E
I
V
V
V
E
D
---
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
49.01
14%
-39
* C4 *
3TUI
1
METN_ECOLI
C:
[53-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
Q
I
Y
GVIGA
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
--
R
P
T
-
E
G
S
V
L
V
D
--
G
Q
E
L
T
T
--
L
---
S
E
SEL
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
--
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
--
E
L
--
D
-----------
N
TPKDEVKRRVT
E
L
L
S
L
V
G
L
G
D
K
H
---------------
D
----
S
----
Y
----
P
----
S
N
L
S
G
G
Q
-
K
Q
R
V
A
I
A
R
A
L
A
S
-------------
N
P
K
V
L
L
C
--
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
-
R
I
C
D
C
V
A
V
I
S
N
---
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
L
G
Y
V
-------------------------------------------------------------------------------------
30
HHSearch
48.32
17%
-37
- C4 -
1V43
-
?
A:
[37-223]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
E
F
L
V
LLGP
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
--
E
P
T
-
E
G
R
I
Y
F
G
--
D
R
D
V
T
Y
--
L
---
P
P
-----
K
D
R
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
F
P
L
------
K
-----------
K
FP
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
L
L
---------------
N
----
R
----
Y
----
P
----
A
Q
L
S
G
G
Q
-
R
Q
R
V
A
V
A
R
A
I
V
V
-------------
E
P
D
V
L
L
M
--
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
-
M
G
D
R
I
A
V
M
N
R
---
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
D
G
Y
L
E
G
R
G
F
R
I
E
L
P
Q
M
D
L
L
K
D
Y
V
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
H
M
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
E
L
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
-
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
V
--------------------------------------------------------------
26
HHSearch
48.13
13%
-14
- C4 -
3WMG
1
?
A:
[378-572]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
P
Q
G
G
G
L
L
L
F
D
--
G
T
P
A
W
N
--
Y
---
D
F
---
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
---
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
K
--
R
D
--
A
T
D
E
E
V
------
I
-----------
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
----
L
----
D
----
T
----
E
----
V
G
ER
G
L
A
L
S
G
G
Q
-
K
Q
R
I
A
I
A
R
A
I
L
K
-------------
H
P
T
L
L
C
L
--
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
--
R
A
D
L
I
L
V
M
Q
D
---
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
G
P
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
47.94
18%
-35
- C4 -
2IT1
-
?
A:
[28-214]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
E
F
M
A
LLGP
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
--
K
P
T
-
S
G
K
I
Y
F
D
--
E
K
D
V
T
E
--
L
---
P
-----
P
K
D
R
N
V
G
L
V
F
Q
N
W
--
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
L
--
E
L
--
R
-----------
K
AP
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
-------------------
R
----
Y
----
P
----
W
Q
L
S
G
G
Q
-
Q
Q
R
V
A
I
A
R
A
L
V
K
-------------
E
P
E
V
L
L
L
--
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
-
A
M
A
D
R
I
A
V
I
R
E
---
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
N
F
V
E
A
K
V
E
D
G
K
L
V
I
T
E
K
S
K
L
P
I
P
K
Q
Y
V
E
I
V
K
E
T
G
I
T
E
V
I
I
G
F
R
P
H
D
A
E
I
V
K
G
E
G
E
G
I
V
G
E
V
Y
S
F
E
P
L
G
R
E
Q
I
V
T
V
S
V
N
D
S
I
V
K
V
F
A
P
E
G
E
H
F
S
F
G
E
K
V
-
T
I
K
V
K
E
E
L
L
V
L
F
D
K
K
T
E
K
A
L
E
F
S
K
L
----------------------------------------------------------
55
Fugue
47.63
18%
23
- C1 -
2W0C
1
SPIKE_BPPM2
L:
[1-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
V
K
K
K
L
A
A
G
E
F
A
E
T
F
K
N
G
N
N
I
-
T
----
I
I
K
A
V
G
E
L
V
L
R
A
Y
G
A
D
G
G
E
G
L
R
----
T
I
V
R
Q
G
V
-
S
I
K
G
M
N
Y
T
S
V
M
L
H
T
E
Y
A
Q
E
I
E
Y
W
V
G
D
L
D
Y
S
F
Q
E
Q
--------
T
T
K
S
R
D
V
N
S
F
Q
I
P
L
R
D
G
V
R
E
L
L
P
E
D
A
S
R
N
R
A
S
I
K
S
P
V
D
I
W
I
G
G
E
N
M
T
A
L
N
G
IV
D
G
G
R
K
F
E
A
G
Q
E
F
Q
I
N
T
F
G
S
V
N
Y
W
V
-----
S
D
E
E
I
R
V
F
K
E
Y
S
A
R
A
K
Y
A
Q
N
E
-
G
R
T
A
L
E
A
N
N
V
P
F
F
D
I
--
D
---
V
P
---
P
E
L
D
G
V
----------
P
F
S
L
K
A
R
V
R
H
K
S
K
G
V
D
GL
G
D
--
Y
-----------
T
-----------
S
I
S
V
K
P
A
F
Y
I
T
E
G
D
E
T
T
D
----
T
--------------
L
----
I
----
K
Y
T
S
Y
G
--------------
S
T
G
S
-
H
SG
Y
D
F
D
-
D
N
T
L
D
V
M
VT
L
S
A
G
V
H
R
V
F
P
V
E
T
E
L
D
Y
D
A
V
Q
E
V
Q
H
D
W
Y
D
E
S
F
T
T
F
I
E
V
Y
S
D
D
P
L
L
T
V
K
G
Y
A
Q
I
L
M
E
R
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
47.25
16%
-31
- C4 -
1OXX
17
?
K:
[30-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
E
R
F
GILGP
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
--
V
P
S
-
T
G
E
L
Y
F
D
--
D
R
L
V
A
S
--
N
GKL
I
V
---
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
--
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
--
T
N
--
M
KMSKEEIRKRV
E
-----------
E
V
A
K
I
L
D
I
H
H
V
L
N
-------------------
H
----
F
----
P
----
R
E
L
S
G
A
Q
-
Q
Q
R
V
A
L
A
R
A
L
V
K
-------------
D
P
S
L
L
L
L
--
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
-
A
I
A
D
R
V
G
V
L
V
K
---
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
-
D
K
I
K
V
F
E
K
---------------------------------------------------------------------------
39
HHSearch
45.81
12%
-33
- C4 -
3RLF
3
MALK_ECOLI
A:
[28-214]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
--
T
I
T
-
S
G
D
L
F
I
G
--
E
K
R
M
N
D
--
T
---
P
-----
P
A
E
R
G
V
G
M
V
F
Q
S
Y
--
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
--
K
L
--
A
-----------
G
AK
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L
L
---------------
D
----
R
----
K
----
P
----
K
A
L
S
G
G
Q
-
R
Q
R
V
A
I
G
R
T
L
V
A
-------------
E
P
S
V
F
L
L
--
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
-
T
L
A
D
K
I
V
V
L
D
A
---
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
V
A
------------------------------------------------
41
HHSearch
45.45
13%
-14
- C4 -
3NH6
2
A:
[89-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
--
I
S
-
S
G
C
I
R
I
D
--
G
Q
D
I
S
Q
--
V
---
T
Q
---
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
---
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
R
--
V
T
--
A
G
N
D
E
V
------
E
-----------
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
----
Y
----
R
----
T
Q
V
G
E
R
----
G
----
L
K
L
S
G
G
E
-
K
Q
R
V
A
I
A
R
T
I
L
K
-------------
A
P
G
I
I
L
L
--
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
--
N
A
D
Q
I
L
V
I
K
D
---
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
G
G
V
Y
A
D
M
W
Q
L
Q
Q
G
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
45.33
14%
-32
- C4 -
3FVQ
3
FBPC_NEIG1
A:
[39-219]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
--
Q
P
D
-
S
G
E
I
S
L
S
--
G
K
T
I
F
S
KN
T
---
N
L
---
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
--
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
--
G
N
--
G
-----------
K
GRT
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
---------------
G
----
R
----
Y
----
P
----
H
E
L
S
G
G
Q
-
Q
Q
R
A
A
L
A
R
A
L
A
P
-------------
D
P
E
L
I
L
L
--
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
-
Q
Y
A
D
R
I
A
V
M
K
Q
---
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
I
V
F
P
A
A
L
N
A
D
G
T
A
D
C
R
L
G
R
L
P
V
Q
S
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
H
P
H
S
A
P
A
A
S
I
H
A
V
V
L
K
T
T
P
K
A
R
H
T
E
I
S
L
R
A
G
Q
T
V
L
T
L
N
L
L
S
D
G
I
S
A
V
L
H
L
D
G
P
A
L
F
F
-
P
G
---------------------------------------------------------------------------------
27
HHSearch
44.69
14%
-31
- C4 -
1Z47
1
?
A:
[40-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
--
R
P
T
-
K
G
D
V
W
I
G
--
G
K
R
V
T
D
--
L
---
P
P
-----
Q
K
R
N
V
G
L
V
F
Q
N
Y
--
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
--
R
E
--
K
-----------
R
VP
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
---------------
N
----
R
----
F
----
P
----
H
E
L
S
G
G
Q
-
Q
Q
R
V
A
L
A
R
A
L
A
P
-------------
R
P
Q
V
L
L
F
--
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
-
E
V
A
D
R
V
L
V
L
H
E
---
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
D
G
E
V
W
E
V
H
V
P
S
A
D
R
H
R
W
S
P
G
A
W
V
H
M
N
V
T
R
-
W
F
I
F
P
R
-----------------------------------------------------------------------------
40
HHSearch
43.71
14%
-34
- C4 -
3GD7
2
CFTR_HUMAN (first)
A:
[46-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
Q
R
V
G
L
L
G
R
T
G
S
G
K
S
T
L
L
S
A
F
L
R
L
L
N
---
T
-
E
G
E
I
Q
I
D
--
G
V
S
W
D
S
--
I
---
T
L
---
E
Q
W
R
K
A
F
G
V
I
P
Q
K
V
---
F
I
F
S
G
T
F
R
K
N
L
D
P
N
A
--
A
H
--
S
D
Q
E
I
-------
W
-----------
K
V
A
D
E
V
G
L
R
S
V
I
E
Q
F
P
G
K
----
L
----
D
F
V
L
V
D
----
G
----
G
----
C
V
L
S
H
G
H
-
K
Q
L
M
C
L
A
R
S
V
L
S
-------------
K
A
K
I
L
L
L
--
D
E
P
S
A
H
L
D
P
V
T
Y
Q
I
I
R
R
T
L
K
Q
A
F
A
--
D
C
T
V
I
L
C
E
A
R
I
E
A
M
L
--
E
C
D
Q
F
L
V
I
E
E
---
N
K
V
R
Q
Y
D
S
I
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
V
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
-
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
R
R
L
H
K
E
P
G
--------------------------------------------------
46
HHSearch
43.49
16%
-17
- C4 -
1MV5
2
LMRA_LACLA
A:
[37-217]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
--
P
T
-
A
G
E
I
T
I
D
--
G
Q
P
I
D
N
--
I
---
S
L
---
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
---
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
--
E
G
--
D
Y----------
T
D
E
D
L
W
------
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
----
L
N
T
E
V
G
----
E
----
R
----
G
----
V
K
I
S
G
G
Q
-
R
Q
R
L
A
I
A
R
A
F
L
R
-------------
N
P
K
I
L
M
L
--
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
--
D
A
D
K
I
Y
F
I
E
K
---
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
H
P
L
Y
A
K
Y
V
S
E
Q
L
T
V
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------