@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0195: (2015-12-13 )
MHGFFLSAFEYQVSARVGSFSRIAFNQSIINSKKGIYPTGSYVTTTGALQVDSSLLPKGIENHKLGFGVGGEIGALAYDSTKFLIDEANPKAGFQPANWYYMGRWEGYLMQHSQNWTREQKAQNARPYVLYNLYLDYQYKDIFGIKLGRYPSKALFLSGFNQGFEIFYRWKKFKIVWFSTFGRALANEQYIRDFYAPVNYKQKINYGMHNFNLVYENKYIRIAPFIWFYPKNFNAPGFEITHDTKSYWKSLWRIQTTFYAWFPLYSDYLSKDYYRAALVGKKSAALFVFQRVNFRSYRFGWSVYKNFGNASVQLGWNGSPIDPFYDTKDDTPYEDAYSNFYNANSITINAFIGKSIKNLLVQLYGKLTYSPRADAQSLGVTFKYNLKKHIYFMLMVNGYQITMHKGYKVGFFTSGYNPDFAQTIQNRSYLMSSMSYRF
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------........------.10...-----.....20--........30-------------------..---....--.--------.40.....--...50..-......60........70........80-........-.--------------90.......----.100.......110.......120......-.130--------.--...--------....140-..------......150--.-----......-----.--------160------...--.-.....170-----..---...-------..--------------..180.....---------...----190--...-----....-----200.----........210......----..220-...------...----...230.......240..---.-....250.------------------......260....-....270.....-----..280..---.....290.....--..300.......310-......--.----320--------------------.......330-......---..-340.......350.....-----.-----.---360---.......--------.-----------------------370------------------.......--..380....-------.----.----.390..----------.....400---------------.....-....410..--------------.....420----------....--.-----...430---......------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------MH
G
F
F
L
S
A
------
F
E
Y
Q
V
S-----ARVG
S
F
S
--
R
I
AF
N
Q
S
I
IN-------------------SK---KGIY--P--------TG
S
Y
V
T
T
T--
G
A
L
Q
VD
S
-
S
LLPKGIENHKLGFGVGGE
I
G
A
L
A
YDS--
T
K
F
L
I
DEA-N--------------PKAGFQPA
N
----
W
Y
Y
M
G
R
WE
G
Y
L
M
QHSQNW
T
R
E
Q
KAQNAR
P
Y
-
V
L
Y
---------
N
--
L
Y
L
--------
D
Y
Q
Y
K
-
D
-
I
F
------
G
I
KLGRYP---S-----
K
A
L
F
L
S
-----G--------F--------NQ
G
--
F
-
E
I
F
Y
R
W
-------
K
K
---
F
K
I
-------
V
W
--------------
F
S
T
F
-
G
R
A
LA---------
N
E
Q
----
Y
I
R
--
D
F
Y-----APVN-----Y--
K
----
Q
KINYGMH
N
-
F
N
L
V
Y
EN----
K
Y
I
---
R
IA------
P
F
I
----
W
F
YPKNFNAPG
F
E
I
THD
T
---
K
-
S
Y
W
K
S
L
W
R
------------------
I
Q
T
T
F
Y
A
-
W
F
P
L
Y
-
S
D
Y
L
S
K
D
Y
Y
R
A
A
-----LVGKK
S
A
---
A
L
F
V
F
Q
RVNF
R
S
Y
--
R
F
G
W
S
V
Y
K
NFGN
A
S
V
-
Q
LGWNG--S----PID--------------------PFYDTKDD-T-
P
Y
E
D
A
Y
---
S
N-FYNA
N
S
I
T
I
N
A
F
I
G
K
S
I
K
-----
N
-----
L
---
L
V
----
Q
L
Y
G
KLT--------Y-----------------------S--------------------PRAD
A
Q
S--L
G
V
T
F
K
YNL-------K----
K
----
H
I
Y
F
M
L
----------
M
VN
G
Y
Q
-----------------
I
T
M
HK-
G
Y
K
V
G
F
F
TS--------------GYN
P
D
F
A
-----------
Q
T
I
Q
--
N
-----
R
S
Y
L
M
S
---SMSYRF------------------------------------------------------------------------------------------------------
25
Fugue
86.79
18%
-52
- C4 -
4C2E
-
CTPB_BACSU
A:
[2-436]
------------------------------------------------------------------------------AD
S
E
R
D
K
A
M
D
K
I
E
K
A
------
Y
E
L
I
S
N
-----
E
Y
V
E
K
V
D
--
R
E
K
L
L
E
G
A
I
Q
-------------------
G
M
---
L
S
T
L
ND
P
--------
Y
S
V
Y
M
D
K
Q
--
T
A
K
Q
F
S
D
-
S
L
D
S
S
---
F
E
G
I
G
A
E
V
G
M
E
D
G
K
I
I
I
V
S
PF
K
K
S
P
A
E
K
A
-
G
LK------------
P
N
D
E
I
I
S
I
N
----
G
E
S
M
---
A
G
K
D
L
N
H
A
V
L
K
I
R
G
K
K
G
S
S
V
S
M
K
-
I
Q
R
---------
P
-------------
G
T
K
K
Q
-
L
-
S
F
------
R
I
K
R
A
E
I
P
---
L
-----
E
T
V
F
A
S
E
K
K
V
Q
G
--------
H
--------
S
V
G
--
Y
-
I
A
I
S
T
F
-------
S
E
---
H
T
T
-------
E
D
--------------
F
A
K
A
-
L
R
E
L
E
---------
K
K
E
IE
G
L
V
I
D
--
V
R
G
-----
N
P
G
G
-----
Y
--
I
----
Q
S
V
E
E
I
L
K
H
-
F
--
V
T
K
D
----
Q
--------------
P
Y
I
----
Q
I
A
E
R
N
G
D
K
K
R
Y
F
S
T
L
T
H
---
K
-
K
A
Y
P
V
N
V
I
------------------
T
D
K
G
S
A
A
-
A
S
E
I
L
-
A
G
A
L
-
K
E
A
G
H
Y
D
-----
V
V
G
D
T
S
F
---
G
K
G
T
V
Q
Q
A
V
P
M
G
D
G
S
N
I
K
L
T
L
Y
K
W
L
T
P
N
G
N
-
W
I
H
K
K
G
--------
I
E
--------------------
P
T
I
A
I
K
Q
-------------
P
D
-
Y
F
S
A
G
P
L
Q
L
K
E
P
L
K
V
D
M
N
-----
N
-----
E
---
D
V
----
K
H
A
Q
V
L
L
--------
K
-----------------------
G
--------------------
L
S
F
D
P
G
R
--
E
D
G
Y
F
S
K
D
M
-------
K
----
K
----
A
V
M
A
F
Q
----------
D
Q
N
K
L
N
-----------------
K
T
G
I
I
-
D
T
R
T
A
E
T
L
N
--------------
Q
Q
I
E
K
K
K
-----------
S
D
E
K
--
N
-----
D
L
Q
L
Q
T
---
A
L
K
S
L
F
------------------------------------------------------------------------------------------------------
31
Fugue
76.92
13%
-57
- C5 -
2SCU
2
SUCC_ECOLI
B:
[1-385]
------------------------------------------------------------------------------------------
M
N
L
------
H
E
Y
Q
A
K
-----
Q
L
F
A
R
Y
G
--
L
P
A
P
V
G
Y
A
C
T
-------------------
T
P
---
R
E
A
E
--
E
--------
A
A
S
K
I
G
A
G
---
P
W
V
V
K
C
-
Q
V
H
A
G
G
R
G
K
A
-------
G
--
G
V
K
V
V
N
S
--
K
E
D
I
R
A
F
A
-
E
--------------
N
W
L
G
------------------
K
R
L
V
T
Y
Q
T
D
A
N
G
Q
P
V
N
Q
-----
I
L
V
---------
E
--
A
A
T
--------
D
I
A
K
E
-
L
-
Y
L
------
G
A
V
V
D
R
S
S
---
R
-----
R
V
V
F
M
A
-----
S
--------
T
--------
E
G
G
VE
I
-
E
K
V
A
E
E
-------
T
P
---
H
L
I
-------
H
K
--------------
V
A
L
D
-
P
L
T
G
P
---------
M
P
Y
----
Q
G
R
--
E
L
A
-----
F
K
L
G
-----
L
--
E
G
K
L
V
Q
Q
F
T
K
I
F
M
G
-
L
A
T
I
F
L
E
R
DL-
A
L
I
---
E
I
N
------
P
L
V
----
I
T
K
Q
G
D
L
I
C
L
D
G
K
L
G
A
D
G
---
N
-
A
L
F
R
Q
------------------------------
P
D
L
R
-
E
M
R
D
Q
S
Q
E
D
P
R
E
-----
A
Q
A
A
Q
W
E
---
L
N
Y
V
A
L
D
G
N
I
G
C
M
--
V
N
G
A
G
L
A
M
G
T
M
D
I
V
K
-
L
H
G
G
E
P
--
A
---------------------------
N
F
L
D
V
G
G
G
-
A
-
T
K
E
R
V
T
---
E
A
-
F
K
I
I
L
S
-------
D
D
K
V
K
-----
A
-----
V
---
L
V
----
N
I
F
G
G
I
V
--------
R
-----------------------
C
--------------------
D
L
I
A
D
G
I
--
I
G
A
V
A
E
V
G
V
-------
N
----
V
----
P
V
V
V
R
L
----------
E
G
N
N
----------------------
A
E
-
L
G
A
K
K
L
A
D
S
--------------
G
L
N
I
I
A
A
-----------
K
G
L
T
--
D
-----
A
A
Q
Q
V
V
---
A
A
V
---------------------------------------------------------------------------------------------------------
30
Fugue
72.18
18%
-48
- C1 -
4R4X
2
?
A:
[1-546]
----------------------------------------------------------------------------------A
Q
T
Y
E
I
T
Y
Q
N
S
------
F
E
G
K
I
N
QN
H
I
I
S
I
T
N
S
D
K
--
T
L
L
F
N
E
K
I
K
N
KKADFP
F
E
V
N
E
I
NRKNN
E
V
S
Q
---
F
A
F
L
--
N
--------
N
N
E
I
V
K
T
S
--
D
N
T
I
L
A
K
Q
E
F
K
P
T
S
E
T
G
K
I
L
G
Y
N
V
K
K
A
V
T
S
V
--
N
S
--
N
T
I
E
V
W
Y
T
-
N
DLKVKGG-------
P
S
I
L
G
Q
D
L
G
----
L
V
L
K
T
V
R
N
G
S
S
V
V
E
A
T
S
V
K
K
I
K
A
L
D
D
Q
S
L
F
-
N
G
K
---------
N
--
I
T
E
K
D
------
A
L
T
Y
K
-
D
M
I
W
------
K
S
R
F
I
T
I
P
V
F
E
N
-----
E
T
I
N
F
S
-----
D
--------
A
--------
S
K
S
--
D
-
Q
V
I
Q
R
F
GNGT
I
I
L
K
K
---
V
K
I
P
EIKQG
N
T
I
--------------
F
V
E
L
-
K
Q
K
S
N
---------
G
D
A
----
Y
D
R
T
G
D
V
F
I
I
P
QE
R
A
I
S
-----
Y
--
Y
----
T
G
L
T
Q
G
V
K
S
-
L
P
-
V
Y
Q
N
GNG
K
S
Y
Q
---
G
V
A
LTPDYL
P
F
I
EL
M
R
F
F
T
P
F
G
I
G
H
F
N
E
K
I
Q
L
K
G
---
K
-
N
-
W
H
N
N
T
P
------------------
Y
R
Q
D
I
T
E
-
L
R
P
Q
L
-
S
G
---
K
E
I
L
I
G
A
-----
F
I
G
N
Y
D
K
-----------
G
G
H
Q
I
--
S
L
E
L
S
I
H
P
D
Q
------
Q
K
I
V
N
N
--
N
----
F
V
L
--------------------
P
V
F
N
T
T
N
V
M
E
M
A
G
Q
D
-
Y
---
P
T
M
F
N
S
D
K
G
V
E
V
D
F
I
L
T
K
D
L
K
-----
N
-----
A
---
Q
L
----
R
Y
I
T
T
G
H
G
GWGAGDE
F
-----------------------
V
--------------------
P
K
E
N
S
I
Y
--
L
D
G
K
L
A
H
A
F
T
P
W
R
TDC
G
----
S
----
Y
R
L
F
N
P
----------
A
S
G
N
F
E
DGLSSSDLSRSNWCPG
T
I
T
N
P
V
-
Y
I
N
L
G
N
L
N
A
--------------
G
K
H
T
I
Q
V
K
I
P
Q
G
A
P
E
GS
S
Q
S
F
W
--
N
-----
V
S
G
V
L
L
---
G
Q
E
H
H
H
H
H
H
HH-------------------------------------------------------------------------------------------------
28
Fugue
71.98
16%
-41
- C2 -
4ZCF
2
?
C:
[6-810]
TLEKNL
P
H
Q
K
A
G
V
D
A
V
M
N
V
F
VS
A
T
P
H
L
T
DN
V
A
V
R
L
L
ANPELKLS
E
Q
Q
Y
Y
N
N
I
K
N
V
Q
A
F
N
GIAHSKDNHNAKSN
I
I
D
V
S
M
E
T
GTG
K
T
Y
T
Y
I
K
T
I
------
F
D
L
N
K
S
-----
F
G
I
N
K
F
I
--
I
I
V
P
T
L
S
I
K
A
-------------------
G
T
---
V
N
F
L
--
K
S
D
A
L
K
E
H
F
R
D
D
Y
K
R
E
L
--
R
T
Y
V
V
E
S
-
Q
K
M
P
Q
A
I
H
D
F
V
E
A
S
N
F
K
K
Y
I
H
V
L
V
I
N
S
--
G
M
I
N
S
K
S
L
-
T
DTYD
T
G
L
LDNQFNT
P
V
D
A
L
R
A
V
K
----
P
F
I
I
I
D
E
P
H
R
F
P
T
G
K
K
T
W
E
N
I
E
K
-
F
N
A
Q
Y
I
-
I
R
Y
GATFSEGYK
N
--
L
V
Y
--------
R
L
T
A
V
-
D
-
A
F
N
D
DL
V
K
G
I
D
A
Y
I
E
D
---
N
-----
A
N
L
K
F
V
-----
K
--------
D
--------
G
K
E
--
A
-
T
F
F
K
L
A
-------
K
S
---
L
S
K
-------
T
H
SAI
H
D
L
T
L
D
A
LNTA
V
L
S
N
-
G
I
E
L
K
---------
I
G
S
----
S
I
N
--
P
Y
S
-----
Y
D
Q
T
-----
L
--
A
----
D
N
M
M
R
K
A
V
K
-
E
H
F
K
L
E
K
----
E
L
L
T
QP
R
I
K
------
P
L
T
----
L
F
F
I
D
D
L
K
T
K
F
E
E
Y
V
L
A
E
---
A
-
N
E
L
L
Y
K
N
Y
------------------
L
E
K
T
V
T
N
-
I
S
S
V
H
-
G
G
Y
I
E
Q
E
I
N
E
I
L
H
D
K
EL
L
L
S
L
D
N
P
---
R
R
F
I
F
S
K
W
T
L
R
E
G
--
W
D
N
P
N
V
F
Q
I
C
K
L
R
S
S
-
K
L
Q
E
V
G
--
R
GL
R
L
P
V
N
EYMCRVKN
F
T
L
K
Y
Y
V
D
FTEK
D
F
V
D
S
L
V
K
-
E
-
V
N
E
S
S
P
---
S
K
-
F
T
Q
E
L
K
E
Q
I
D
N
F
K
D
S
D
A
Y
-----
S
-----
R
---
L
K
SELK
E
L
W
D
L
I
N
Q
K
A
V
I
E
--
Y
-----------------------
K
--------------------
I
N
S
E
S
E
F
--
L
S
I
F
K
S
F
M
L
-------
E
----
E
TERS
Y
R
E
F
L
D
----------
N
L
S
Q
T
I
-----------------
F
V
K
H
G
-
T
L
H
K
V
F
C
D
I
--------------
K
D
T
I
L
N
I
-----------
Q
T
I
R
--
K
I
K
S
G
F
S
K
Y
L
L
N
N
SF
S
L
G
Y
N
L
------------------------------------------------------------------------------------------------------
32
Fugue
66.92
15%
-49
- C5 -
5CA8
2
?
A:
[27-687]
----------------------------------------------------------------------DAIQIIDENKHFNTG
I
L
D
Y
I
N
K
T
S
PADVG
N
N
Y
H
I
I
-----
S
V
F
G
S
Q
S
TG
K
S
T
L
L
N
R
L
F
N
-------------------
T
N
FDV
M
G
I
W
--
L
--------
A
Y
S
P
V
V
S
T
TL
G
H
T
T
S
K
S
-
N
I
L
V
M
D
V
E
G
T
D
E
D
Q
D
F
E
R
K
A
A
L
F
A
L
S
T
--
S
E
V
L
I
I
N
I
W
E
--------------
T
Q
V
G
L
Y
Q
G
A
------
N
M
G
L
L
K
T
V
F
E
V
N
L
S
L
F
G
K
S
K
L
E
T
H
N
D
H
K
-
V
L
L
---------
L
--
I
V
I
R
DHVGVTP
V
E
S
L
A
-
K
-
T
F
------
T
L
D
L
Q
N
M
W
---
S
S
LAKP
A
E
L
E
H
L
-----
Q
--------
F
--------
A
D
F
--
F
-
D
V
T
F
H
A
-------
L
N
---
H
K
V
-------
L
Q
--------------
P
K
E
F
-
G
E
G
I
N
R
L
G
D
R
L
VVS
N
E
L
----
F
K
P
--
E
Y
H
-----
H
D
V
P
-----
I
--
D
----
G
W
T
M
Y
A
E
R
C
-
W
E
Q
I
E
T
N
----
K
D
L
---
D
L
P
T
-----
Q
Q
I
----
L
V
A
Q
F
K
C
D
E
I
V
E
S
V
F
Q
E
F
---
L
-
T
K
Y
Q
H
H
F
K
EVDAAPDFEEL
G
A
L
F
A
D
L
R
Q
D
A
F
E
D
-
Y
D
A
S
A
-
S
R
Y
N
K
A
V
Y
E
Q
K
R
-----
K
K
L
R
W
L
I
---
N
D
K
L
K
E
V
F
D
V
H
A
K
--
N
L
C
N
T
L
L
E
K
F
E
K
D
L
V
-
A
L
K
G
K
D
--
F
----
A
V
N
V
-------------------
K
T
L
S
T
K
L
V
-
E
-
D
V
N
F
Q
V
---
S
L
-
M
S
L
Q
G
D
L
S
L
D
E
I
I
L
A
L
T
K
-----
D
-----
I
---
D
A
----
I
V
A
K
Q
Q
V
--------
V
-----------------------
E
--------------------
L
N
S
I
V
N
K
--
S
V
K
K
L
S
A
S
L
-------
S
----
K
----
S
I
Q
F
E
L
G
DPNEE
T
W
D
N
V
L
Q
Q
F
K
-----------------
G
V
Y
E
K
F
G
G
D
F
G
L
G
T
S
S
T
Q
N
Q
Q
A
I
E
KF
K
F
K
S
W
C
Q
F
Y
D
-----------
V
T
H
K
L
I
S
-----
R
E
K
L
L
A
---
L
L
Q
D
R
F
D
D
K
FRYDENG
L
P
K
L
Y
LN
E
Q
D
L
E
K
T
F
A
V
A
K
Q
H
A
L
Q
VLPILT
F
A
K
L
ADGSEIVPDYDIFDSKLREQFLDHCFAEIIT
E
Q
E
K
L
E
V
L
A
K
F
K
K
E
V
D
A
K
Y
I
E
T
K
R
S
I
V
11
HHSearch
58.78
11%
-47
- C7 -
2Y0H
10
?
A:
[88-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
S
-
H
L
G
------------
L
T
A
--------
K
L
R
Y
S
---
Q
T
------
Q
L
Q
V
G
I
L
M
---
P
-----
Q
L
P
V
A
F
-----
R
--------
D
DVRL
L
P
Q
T
F
D
G
--
A
-
L
L
T
S
S
E
-------
I
E
G--
L
T
L
-------
T
A
--------------
G
Q
L
W
-
K
S
R
T
R
---------
E
-------
S
D
--
D
M
Y
-----
I
M
G
R
-----
D
--
K
----
A
H
A
S
D
E
F
N
L
-
A
G
A
T
Y
A
F
T---
P
R
L
---
S
A
S
------
Y
Y
Y
----
G
Q
L
K
D
I
Y
R
Q
H
Y
L
G
L
L
H
T
L
---
P
-
L
G
--
E
G
L
S
------------------
L
R
S
D
L
------
R
Y
-
F
D
S
G
E
D
G
A
--
A
I
-----
S
G
P
V
D
N
R
---
N
L
N
A
M
L
T
L
R
A
G
A
H
--
A
F
G
I
G
V
Q
K
M
I
G
N
D
A
F
P
V
L
N
G
Y
T
--
T
--------------------------------------
P
Y
V
A
N
L
MAY
Q
T
-
F
T
R
P
Q
E
K
S
W
Q
L
R
Y
D
Y
D
F
A
-----
G
LGLPG
L
---
N
L
----
M
T
R
Y
V
Q
G
--------
R
DIDRGAG----------------
R
--------------------
A
D
D
S
E
W
E
--
R
N
T
D
L
S
Y
V
I
-------
Q
SGPL
K
----
S
V
A
L
K
W
----------
R
N
I
T
Y
R
-----------------
S
R
Y
G
A
-
D
L
D
E
N
R
F
I
V
--------------
N
Y
T
L
K
L
W
--------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
57.07
12%
-35
- C7 -
3SYB
3
?
A:
[136-437]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
W
S
-
K
L
G
---------
V
--
A
N
I
--------
R
L
R
A
S
---
N
T
------
E
F
K
A
G
R
F
L
---
V
-----
N
T
P
V
F
S
-----
Y
I
D
NRA
L
P
S
S
--------
F
T
G
--
F
-
A
V
T
S
E
E
-------
L
D
N
L
S
L
Q
A
-------
G
S
--------------
F
R
K
V
S
P
R
T
-----------
G
S
G
----
D
-
E
--
D
M
T
-----
T
E
Y
G
-----
T
--
R
----
Q
V
K
G
D
R
L
N
Y
-
L
G
G
N
Y
K
P
L---
D
G
L
---
E
I
S
------
L
Y
G
----
S
H
F
Q
D
V
W
N
Q
Y
Y
L
G
V
T
H
D
I
---
G
---
L
E
N
G
I
A
------------------
L
R
T
A
F
N
------
G
-
Y
H
T
G
D
T
G
A
--
R
E
-----
A
G
Y
I
D
N
D
---
T
W
S
L
A
F
T
L
G
H
R
A
H
--
A
L
T
L
A
Y
Q
Q
V
D
G
N
E
Y
--
F
D
Y
V
H
E
--
T
----
S
A
I
--------------------
F
L
--
A
N
S
----
M
----
L
---
A
D
-
Y
N
S
P
N
E
K
S
A
Q
I
R
Y
E
T
D
W
S
YYGVP
G
-----
L
---
S
T
----
G
V
W
Y
V
K
G
--------
W
DIDGTHYDGDRNGAYGNYAEVRA
Q
--------------------
D
G
E
K
H
H
E
--
L
G
L
M
A
A
Y
K
V
-------
Q
NGPI
K
----
D
S
T
F
K
L
----------
T
Y
M
M
H
K
-----------------
A
S
Q
N
Q
-
I
D
G
S
V
N
E
L
R
--------------
L
V
S
T
F
P
F
-----------
N
L
L
------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
56.71
9%
-37
- C7 -
2Y0L
-
?
A:
[98-383]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
Y
S
-
K
L
G
---------
L
---
T
A
--------
K
V
K
V
S
---
Q
S
------
E
L
K
V
G
T
L
I
---
P
-----
K
L
P
S
V
Q
-----
P
NNGRIF
P
Q
I
--------
F
E
G
--
A
-
L
L
T
S
K
E
-------
I
K
D
L
G
F
T
A
-------
G
R
--------------
L
E
K
T
-
K
I
-------------
D
S
------
E
--
D
L
A
-----
L
N
D
K
NGR--
F
--
A
----
G
V
S
A
D
H
F
D
L
-
G
G
L
D
Y
K
L
T---
D
Q
L
---
T
A
S
------
Y
H
Y
----
S
N
L
Q
D
V
Y
R
Q
H
F
V
G
L
L
H
S
W
---
P
-
I
G
--
P
-
G
E
------------------
L
T
S
D
L
------
R
F
-
A
R
S
T
D
S
G
S
--
A
K
-----
A
G
G
I
D
N
K
---
S
L
N
G
M
F
T
Y
S
L
G
N
H
--
A
F
G
A
A
W
Q
R
M
N
G
D
D
-
A
-
F
P
Y
L
E
G
--
S
----
N
-
P
--------------------
Y
L
V
N
--
F
----
V
Q
---
V
---
N
D
-
F
A
G
P
K
E
R
S
W
Q
L
R
Y
D
Y
D
F
V
GLGIP
G
-----
L
---
T
F
----
M
T
R
Y
V
K
G
--------
D
NVELAGQ-------------------------------------
G
E
G
R
E
W
E
--
R
N
T
E
L
Q
Y
V
F
-------
Q
SGAL
K
----
N
L
G
I
R
W
----------
R
N
A
T
F
R
-----------------
S
N
F
T
R
-
D
I
D
E
N
R
L
I
V
--------------
S
Y
T
L
P
I
W
--------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
56.12
9%
-29
- C7 -
3T24
12
?
A:
[94-382]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
-
D
Y
G
---------
E
--
A
G
I
--------
T
A
K
L
R
A
S
-
K
S
------
T
L
K
I
G
T
L
T
---
P
-----
K
L
P
V
I
M
-----
P
--------
N
DSRL
L
P
Q
T
F
Q
G
--
G
-
A
L
N
S
M
E
-------
I
D
G
L
T
L
D
A
-------
G
R
--------------
L
K
K
V
-
N
Q
R
D
-----------
S
S
----
D
N
E
--
D
M
T
-----
I
T
G
G
GKRQI
V
VR
S
----
G
L
T
S
D
K
F
D
F
-
A
G
G
S
Y
K
W
T---
D
N
L
---
S
T
S
------
Y
H
Y
----
G
K
L
D
N
F
Y
K
Q
H
Y
L
G
L
V
H
T
L
---
P
-
I
A
--
D
K
Q
S
------------------
L
K
S
D
I
------
R
W
-
A
R
S
T
D
D
G
----------
S
S
N
V
D
N
K
---
A
L
N
A
M
F
T
Y
S
L
G
Y
H
--
A
F
G
V
G
Y
Q
K
M
S
G
D
T
-
G
-
F
A
Y
I
N
G
--
A
----
D
-
P
--------------------
Y
L
V
N
F
I
Q
---------
I
---
G
D
-
F
A
N
K
D
E
K
S
W
Q
A
R
Y
D
Y
N
F
A
-----
G
VGIPG
L
---
T
F
----
M
T
R
Y
V
K
G
--------
D
-----------------------
N
IDLLT
T
S
-------------
G
E
G
K
E
W
E
--
R
D
M
D
I
A
Y
V
F
-------
Q
SGPL
K
----
N
L
G
V
K
W
----------
R
N
A
T
M
R
-----------------
T
N
Y
T
N
-
D
Y
D
E
N
R
L
I
V
--------------
S
Y
T
L
P
L
W
--------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
55.13
11%
-27
- C7 -
2Y2X
15
?
A:
[91-371]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
G
-
R
V
G
---------
V
--
A
-
A
--------
K
L
R
V
S
-
A
--
S
------
E
L
K
I
G
E
M
L
---
P
-----
D
I
P
L
L
R
-----
Y
D
DGRL
L
P
Q
T
--------
F
R
G
--
F
-
A
V
V
S
R
E
-------
L
P
G
L
A
L
Q
A
-------
G
R
--------------
F
D
A
V
-
S
L
R
N
-----------
S
-------
A
--
D
M
Q
-----
D
L
S
A
-----
W
--
S
AP--
T
Q
K
S
D
G
F
N
Y
-
A
G
A
E
Y
R
F
NR--
E
R
T
---
Q
L
G
------
L
W
H
----
G
Q
L
E
D
V
Y
R
Q
S
Y
A
N
L
L
H
K
Q
---
R
-
V
G
--
D
-
W
T
------------------
L
G
A
N
L
G
L
-----
F
-
V
D
R
D
D
G
A
---
A
R
-----
A
G
E
I
D
S
H
---
T
V
Y
G
L
F
S
A
G
I
G
L
H
--
T
F
Y
L
G
L
Q
K
V
G
G
D
S
-
G
-
W
Q
S
V
Y
G
S-
S
----
G
R
S
M-------------------
G
N
D
M
F
N
--------------
G
N
-
F
T
N
A
D
E
R
S
W
Q
V
R
Y
D
Y
D
F
V
GLGWP
G
-----
L
---
I
G
----
M
V
R
Y
G
H
G
--------
S
NATTKA-----------------
G
--------------------
S
G
G
K
E
W
E
--
R
D
V
E
L
G
Y
T
V
-------
Q
SGPL
A
----
R
L
N
V
R
L
----------
N
H
A
S
N
R
-----------------
R
S
F
N
S
-
D
F
D
Q
T
R
L
V
V
--------------
S
Y
P
L
S
W
---------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
52.80
11%
-28
- C7 -
3SY9
8
?
A:
[98-398]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
F
-
S
S
G
---------
G
--
A
A
L
--------
K
I
R
A
F
---
D
T
------
E
L
K
L
G
D
Q
F
---
L
-----
S
N
P
V
V
A
-----
G
GESRM
L
P
Q
T
--------
F
R
G
--
V
-
S
L
T
N
N
S
-------
F
E
D
L
T
L
T
A
-------
G
Q
--------------
V
S
F
T
-
K
Y
--
Y
---------
N
--------------------------------------
D
S
H
H
L
S
W
-
L
G
G
T
W
G
G
I---
E
G
F
---
T
S
S
------
L
Y
A
----
A
E
L
Q
N
V
W
K
Q
Y
Y
A
D
V
D
Y
T
Y
---
E
-
I
D
--
D
N
W
S
------------------
L
N
P
G
A
------
H
Y
-
Y
K
T
V
D
S
G
D
--
S
L
-----
L
G
R
I
D
N
N
---
T
Y
S
L
H
F
A
V
G
Y
R
Q
H
--
T
V
T
A
V
L
Q
K
V
N
G
N
T
P
---
F
D
Y
I
N
--
Q
------
G
--------------------
D
S
I
F
L
D
N
----
S
Q
Q
Y
-----
S
D
-
F
N
G
P
N
E
K
S
W
K
L
Q
Y
D
Y
D
F
V
-----
A
LGVPG
L
---
S
A
----
S
A
S
Y
S
R
G
--------
K
-----------------------
L
D
LTRVDPDSPGYGGWYSADG
K
N
A
K
H
W
E
--
R
D
L
D
L
Q
Y
V
V
-------
Q
GGPA
K
----
D
L
S
L
R
L
----------
R
W
A
T
H
R
-----------------
G
T
G
G
Y
-
S
A
V
D
N
D
I
D
E
--------------
Y
R
V
I
V
D
Y
-----------
P
I
D
V
--
F
--------------------------------------------------------------------------------------------------------------------------
13
HHSearch
52.42
8%
-23
- C7 -
3SZV
6
?
A:
[104-381]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
A
-
K
L
G
---------
L
--
T
-
A
--------
K
A
R
V
S
---
N
S
------
L
L
K
V
G
A
L
H
---
F
-----
K
S
P
L
V
S
-----
A
N
D
TRL
L
P
E
L
--------
F
R
G
--
A
-
L
L
D
V
Q
E
-------
I
D
G--
L
T
L
-------
R
G
--------------
A
H
L
D
-
R
N
K
L
N
---------
S
S
S
----
D
Y
Q
--
V
F
S
-----
A
N
R
I
-------------
G
G
R
S
D
A
F
D
F
-
A
G
G
D
Y
R
L
T---
P
A
L
---
T
A
S
------
L
H
Q
----
G
R
L
K
D
I
Y
R
Q
T
F
A
G
L
V
H
T
L
---
D
-
L
G
----
R
S
------------------
L
K
S
D
L
-----
R
F
A
-
R
A
S
-
E
D
----
G
G
-----
F
R
E
L
D
N
R
---
A
F
G
A
L
F
S
L
R
L
G
A
H
--
A
V
A
A
G
Y
Q
R
I
S
G
D
D
-
P
-
Y
P
Y
I
A
G
--
S
----
D
-
P
-----------------------
Y
L
V
N
----
F
I
--
Q
I
---
G
D
-
F
G
N
V
D
E
R
S
W
Q
L
R
Y
D
Y
D
F
G
ALGLP
G
-----
L
---
S
F
----
M
S
R
Y
V
S
G
--------
D
NVARGA-----------------
A
--------------------
N
D
G
K
E
W
E
--
R
N
T
D
L
G
Y
V
V
-------
Q
SGPL
K
----
N
L
G
V
K
W
----------
R
N
A
T
V
R
-----------------
S
N
F
A
N
-
D
L
D
E
N
R
L
I
L
--------------
S
Y
S
L
A
L
W
--------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
51.21
9%
-28
- C7 -
3SY7
6
PORD_PSEAE
A:
[95-398]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
S
-
R
A
G
---------
G
--
A
-
V
--------
K
V
R
I
S
---
K
T
------
M
L
K
W
G
E
M
Q
---
P
-----
T
A
P
V
F
A
-----
A
GGSRLF
P
Q
T
--------
A
T
G
--
V
-
Q
L
Q
S
S
E
-------
F
E
G
L
D
L
E
A
-------
G
H
--------------
F
T
E
----------------------------
E
L
Y
-----
A
T
Y
---------
A
----
G
E
T
A
K
S
A
D
F
-
I
G
G
R
Y
A
I
T---
D
N
L
---
S
A
S
------
L
Y
G
----
A
E
L
E
D
I
Y
R
Q
Y
Y
L
N
S
N
Y
T
I
---
P
-
L
A
--
S
D
Q
S
------------------
L
G
F
D
F
------
N
I
-
Y
R
T
N
D
E
G
K
--
A
K
-----
A
G
D
I
S
N
T
---
T
W
S
L
A
A
A
Y
T
L
D
A
H
--
T
F
T
L
A
Y
Q
K
V
H
G
D
Q
P
F
---
D
Y
I
G
--
F
----
G
------------------------
G
A
G
G
D
S
---
I
F
L
A
N
S
VQY
S
D
-
F
N
G
P
G
E
K
S
W
Q
A
R
Y
D
L
N
L
A
SYGVP
G
-----
L
---
T
F
----
M
V
R
Y
I
N
G
--------
K
-----------------------
D
IDGTKMSDNN
V
G
Y
K
N
YGYG-
E
D
G
K
H
H
E
--
T
N
L
E
A
K
Y
V
V
-------
Q
SGPA
K
----
D
L
S
F
R
I
----------
R
Q
A
W
H
R
-----------------
A
N
A
D
Q
-
G
E
G
D
Q
N
E
F
R
--------------
L
I
V
D
Y
P
L
-----------
S
I
L
G
-----------------------------------------------------------------------------------------------------------------------------
29
Fugue
50.67
16%
-5
- C3 -
2AXO
-
?
A:
[38-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
----
E
A
V
K
G
V
V
E
L
F
T
---
S
Q
G
C
A
S
C
P
P
A
D
E
A
L
R
K
M
I
Q
K
---------
G
DV
V
G
L
--------
S
Y
H
V
--
D
-
Y
W
------
N
Y
L
G
W
T
D
S
---
L
-----
A
S
K
E
N
T
-----
E
--------
R
--------
Q
Y
G
--
Y
M
R
A
L
G
R
--------
N
G
---
V
Y
T
-------
P
Q
--------------
A
I
L
N
-
G
R
D
H
V
---------
K
G
A
----
D
V
R
--
G
I
Y
-----
D
R
L
D
-----
A
--
F
----
K
R
E
G
Q
G
L
N
V
P
V
S
S
K
F
A
G
----
D
E
V
---
E
I
D
------
I
G
A
----
G
N
G
K
A
D
V
V
V
A
Y
F
T
R
E
Q
T
V
D
VK
K
M
S
Y
W
H
S
V
Y
D
------------------
V
Q
T
V
--
G
M
W
D
G
S
P
M
T
V
K
L
P
A
S
V
V
A
K
V
--------
K
K
G
G
---
C
A
V
L
L
Q
T
A
N
A
S
G
D
--
P
A
A
I
V
G
A
S
I
L
L
G
N
E
T
-
Q
L
E
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
49.07
17%
-23
- C6 -
1YRZ
-
?
A:
[1326-1416]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
A
P
Q
L
-
H
H
Q
W
N
T
L
R
I
----
P
A
D
--------------------
P
S
W
C
S
L
E
E
-
R
-
P
G
H
L
R
L
---
R
G
-
M
E
S
L
T
S
V
H
S
Q
S
L
V
A
R
R
Q
Q
-----
S
-----
F
---
H
C
----
E
V
E
T
K
L
E
--------
Y
-----------------------
Q
--------------------
P
E
S
F
Q
H
M
--
A
G
L
V
I
Y
Y
D
T
-------
E
----
D
----
H
V
Y
L
H
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
46.67
27%
21
- C4 -
2WYA
2
HMCS2_HUMAN
A:
[343-437]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
-----
L
L
S
H
H
S
A
---
Q
E
L
A
G
S
R
I
G
A
F
S
Y
--
G
S
G
L
A
A
-
S
F
F
S
F
R
V
S
-
Q
D
A
A
P
G
--
S
----
P
L
D
--------------------
K
L
V
S
S
T
S
D
-
L
-
P
K
R
L
A
S
---
R
K
-
C
V
S
P
E
E
F
T
-------
E
I
M
-----
N
-----
Q
---
R
E
----
Q
F
Y
H
K
V
N
--------
F
-----------------------
S
--------------------
P
P
G
D
T
N
S
--
L
F
P
G
T
W
Y
L
E
-------
R
----
V
----
D
E
Q
H
R
R
----------
K
Y
A
R
R
P
-----------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
44.33
12%
-60
- C5 -
2IVN
3
KAE1_PYRAB
A:
[1-325]
-------------------------------------------------------------------------------------
M
L
A
L
G
I
E
G
------
T
A
H
T
L
G
-----
I
G
I
V
S
E
D
--
K
V
L
A
N
V
F
D
T
L
-------------------
T
T
---
E
-------------------------------------------
K
G
G
I
H
P
K
E
A
A
E
H
H
A
R
L
--
M
K
P
L
L
R
K
A
-
L
--------------
S
E
A
G
V
S
L
D
D
ID
V
I
A
F
S
Q
G
P
G
L
G
P
A
L
R
V
V
A
T
A
A
R
A
L
A
V
K
Y
R
K
P
I
-
V
G
V
---------
N
--
H
C
I
--------
A
H
V
E
I
-
T
-
K
M
------
F
---
G
V
K
D
---
P
-----
V
G
L
Y
V
S
-----
G
---------------------------------------------------------------------------------------------------------------------------------
G
N
T
Q
-
V
L
A
L
E
G
G
----
R
Y
R
---
V
F
G
------
E
------------------------------------
T
------------------
L
D
I
G
I
G
N
-
A
I
D
V
F
-
A
R
E
L
G
L
G
F
P
G
G
P
-----
K
V
E
K
L
A
E
K
GE
K
Y
I
E
L
P
Y
A
-
V
K
G
M
--
D
L
S
F
S
G
L
L
T
E
A
I
R
K
Y
-
R
S
G
----------------------------------------
K
-
Y
-
R
V
E
D
L
A
---
Y
S
-
F
Q
E
T
A
F
A
A
L
V
E
V
T
E
R
A
V
A
-----
H
-----
T
EKD
E
V
----
V
L
V
G
G
V
A
--------
A
-----------------------
N
--------------------
N
R
L
R
E
M
L
--
R
I
M
T
E
D
R
G
I
-------
K
----
F
----
F
V
P
P
Y
D
----------
L
C
R
D
-
N
-----------------
G
A
M
I
A
-
Y
T
G
L
R
M
Y
K
A
--------------
G
I
S
F
R
L
E
-----------
E
T
I
V
--
K
-----
Q
K
F
R
T
D
---
E
V
E
I
V
W
H-----------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
37.24
26%
-5
- C4 -
3ZIF
-
CAPSH_ADEB3
A:
[576-673]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
A
S
F
F
P
M
S
H
N
T
---
A
-
S
T
L
E
A
M
L
R
------------------
N
D
T
N
D
Q
S
-----
F
-
N
D
Y
L
S
A
A
N
M
L
Y
P
-----
I
--
P
P
N
A
---
T
Q
L
P
I
P
S
R
N
W
A
A
F
--
R
-
G
W
S
L
T
R
L
K
Q
R
E
T
P
-
A
L
G
-----
S
----
P
F
D
--------------------
P
Y
F
T
Y
S
G
T
-
I
-
P
Y
L
D
G
-----
T
-
F
Y
L
S
H
T
F
R
K
V
A
I
Q
F
D
S
S
V
-----
T
-----
W
---
P
G
----
N
D
R
L
L
T
P
--------
N
-----------------------
E
--------------------
F
E
I
K
I
S
V
--
D
G
E
G
Y
N
V
A
Q
-------
S
----
N
----
M
T
K
D
W
F
----------
L
V
Q
M
L
A
-----------------
N
Y
N
I
G
-
Y
Q
G
Y
H
L
P
P
D
--------------
Y
K
D
R
T
F
S
-----------
F
L
H
N
--
F
-----
I
P
M
C
R
Q
---
V
P
N
P
A
T
------------------------------------------------------------------------------------------------------
34
Fugue
37.12
20%
-13
* C5 *
2GOM
-
FIB_STAAM
A:
[105-165]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
K
E
Q
K
L
I
Q
A
Q
-----
N
-----
L
---
V
R
----
E
F
E
K
T
H
T
--------
V
-----------------------
S
--------------------
A
H
R
K
A
Q
K
A
V
N
L
V
S
F
E
Y
K
V
-------
K
----
K
----
M
V
L
Q
E
R
----------
I
D
N
V
L
K
-----------------
Q
G
L
V
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
33.53
13%
92
- C7 -
2WJR
5
NANC_ECOLI
A:
[122-152]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
D
N
V
H
R
--
W
D
G
Y
V
T
Y
H
I
-------
N
----
S
----
D
F
T
F
A
W
----------
Q
T
T
L
Y
S
-----------------
K
Q
N
D
Y
-
R
Y
A
N
H
K
K
W
A
--------------
T
E
N
A
F
V
L
-----------
Q
Y
H
M
--
T
-----
P
D
I
T
P
Y
---
I
E
Y
D
Y
L
------------------------------------------------------------------------------------------------------