@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0196: (2015-12-13 )
MSNQEYTFQTEINQLLDLMIHSLYSNKEIFLRELISNASDALDKLNYLMLTDEKLKGLNTTPSIHLSFDSQKKTLTIKDNGIGMDKSDLIEHLGTIAKSGTKSFLSALSGDKKKDSALIGQFGVGFYSAFMVASKIVVQTKKVTSHQAYAWVSDGKGKFEISECVKEEQGTEITLFLKEEDSHFASRWEIDSVVKKYSEHIPFPIFLTYTDTKFEGEGDNKKEVKEEKCDQINQASALWKMNKSELKEKDYKDFYQSFAHDNSEPLSYIHNKVEGSLEYTTLFYIPSKAPFDLFRVDYKSGVKLYVKRVFITDDDKELLPSYLRFVKGVIDSEDLPLNVSREILQQNKILANIRSASVKKILSEIERLSKDNKNYHKFYEPFGKVLKEGLYGDFENKEKLLELLRFYSKDKGEWISLKEYKENLKENQKSIYYLLGENLDLLKASPLLEKYAQKGYDVLLLSDEIDAFVMPGVNEYDKTPFRDASHSESLKELGLAEIHDEVKDQFKDLIKAFEENLKDEIKGVELSGHLTSAVALIGDEPNAMMANWMRQMGQSVPESKKTLELNPNHAILQKLLKCEDKEQLSAFIWLLYDGAKLLEKGALKDAKSFNERLNSVLLKAL
Atome Classification :
(20 SA)
.......-..10........20........30........40........50.-.......60.-.--......70........80........90........100.......110.......120.......130.......140.--..-.--.-..150.......160-..---.---...--.--170.......180.......190.......----------------200.......210.......220....---...230.......240.......250.......260.......270.......280.......290.........-300.......310.......320.......330.......340.......350.......360.-......370.-...-....380.......390-.....--...400....---..-.--410--........420.......430.......440.......450.......460.......470.......480...-------.-.--..490..--...--..500------....------....510...-.-...520.......530..---....---..540----.--........550..-..---------.--------.-----...---560.......570...--..----.----.580---.-----........590.......600.......610.......620-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNQ
E
Y
T
-
F
Q
T
E
I
N
Q
L
L
D
L
M
I
H
S
LYSN
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
L
N
Y
L
M
L
T
D
-
E
K
LKGLNTT
P
-
S
--
I
H
L
S
FDSQK
K
T
L
T
I
KDNGIGM
D
K
S
D
L
I
E
H
L
G
T
I
A
K
S
G
T
K
S
F
L
S
A
LSGDKK
K
D
S
A
L
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
S
K
I
V
V
Q
T
KKV--TS-H--
Q
-
A
Y
A
W
VSDGKG
K
F
E
I
S
-
E
C
---
V
---
K
EE--Q--G
T
E
I
T
L
F
L
KEEDSH
F
A
S
RW
E
I
D
S
V
V
K
K
Y
S
E----------------HIP
F
P
I
F
L
T
Y
TD
T
K
FEGEGD
N
K
K
E
V
K
E
---
E
K
C
D
Q
I
N
Q
A
S
A
L
W
KM
N
K
S
E
L
K
E
K
D
Y
K
D
F
Y
Q
S
F
AHDNS
E
P
L
S
Y
I
H
N
KVEGS
L
E
Y
T
T
L
F
Y
IPSKAP--F
D
L
F
R
V
D
Y
K-SG
V
K
L
Y
V
K
R
V
F
ITDD
D
K
E
L
L
P
S
Y
L
R
F
V
K
G
VIDSEDLP
L
N
V
S
R
E
I
L
Q
Q
N
K
I
L
A
N
I
R
S
A
S
V
K
K
I
L
S
-
E
I
E
R
L
SKD-N-K
N
Y
-
H
K
F
Y
E
P
F
G
K
V
L
K
E
GLY--GDFE
N
--
K
E
K
L
L
E
L
L
R
F
---
Y
S-K--DK---G
E
W
I
S
L
K
E
Y
K
E
N
L
K
EN
Q
K
S
I
Y
Y
L
LGENLDLLKA
S
P
L
L
E
K
Y
A
QKG
Y
D
V
L
L
LSDEID
A
F
VMPGVNEYDKTPFRDA
S
-------
H
-
S
--
E
S
L
K
EL
G
--
L
A
E
--
I
H
D
E
-------
V
K
D
Q
------
F
K
D
L
I
K
A
F
E
E
-
N
-
L
K
D
E
IKG
V
E
LSG
H
L
T
-
S
A
---
V
ALI---GDE------P--
N
A
M
M
A
N
W
M
R
--
Q
M
-
G
Q
---------S--------V-----PES---K
K
T
L
ELNP
N
H
A
I
L
Q
K
L
--LK----C----E
D
-----
K
-----
E
Q
L
S
A
F
I
W
L
LYD
G
A
K
L
L
E
K
GALK
D
A
K
S
F
N
E
R
L
N
S
V
L
L
KAL--
1
PsiBlast_PDB
92.06
45%
-80
- C2 -
2IOQ
-
HTPG_ECOLI
A:
[15-623]
--------------
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
-
P
D
L
Y
E
G
D
G
E
L
-
R
--
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
---------------
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
GE
K
P
-
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
-
D
I
---
T
---
K
E
D
--
R
--
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
----------------
H
I
A
L
P
V
E
I
E
K
R
E
E
K
-----
D
G
E
T
V
I
S
W
---
E
K
---
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
N
R
D
H
K
-
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
-
M
L
E
K
L
A
K
D
-
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
--
E
D
F
A
N
--
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
-
D
--
S
S
---
A
Q
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
-------
K
V
D
--
E
S
L
E
K
L
A
-------------------
K
E
A
E
K
A
L
T
P
F
I
D
R
V
K
A
L
-----
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
-
D
T
---
P
A
I
V
S
T
D
A
---------------------------------------------------------
K
Y
I
F
E
L
N
P
D
H
V
L
V
K
R
A
--
A
D
----
T
----
E
D
-----
E
-----
A
K
F
S
E
W
V
E
L
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
S
----
21
PsiBlast_CBE
91.99
45%
-79
- C2 -
2IOP
1
HTPG_ECOLI
D:
[1-623]
M
K
G
Q
E
T
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
-
P
D
L
Y
E
G
D
G
E
L
-
R
--
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
L
G
S
D
Q
A
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
GE
K
P
-
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
-
D
I
---
T
---
K
E
D
--
R
--
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
----------------
H
I
A
L
P
V
E
I
E
K
R
E
E
K
-----
D
--
T
V
I
S
W
---
E
K
---
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
N
R
-
H
K
-
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
-
M
L
E
K
L
A
K
D
-
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
--
E
D
F
A
N
--
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
-
D
--
S
S
---
A
Q
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
-------
K
V
D
--
E
S
L
E
K
L
-----------------------------
F
I
D
R
V
K
A
L
-----
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
-
D
T
---
P
A
I
V
S
T
D
A
D
E
------
M
--
S
T
Q
M
A
K
L
F
A
--
A
A
-
G
Q
---------
K
--------
V
-----
P
E
V
---
K
Y
I
F
E
L
N
P
D
H
V
L
V
K
R
A
--
A
D
----
T
----
E
D
-----
E
-----
A
K
F
S
E
W
V
E
L
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
S
----
104
HHSearch
89.20
46%
-73
- C2 -
2IOQ
-
HTPG_ECOLI
A:
[15-624]
--------------
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
-
P
D
L
Y
E
G
D
G
E
L
-
R
--
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
---------------
K
D
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
--
G
E
-
K
PE
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
-
D
I
---
T
---
K
E
D
--
R
--
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
----------------
H
I
A
L
P
V
E
I
E
K
R
E
E
K
D
--------
G
E
T
V
---
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
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N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
N
R
D
H
K
-
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
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Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
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I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
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L
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-
M
L
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L
A
K
D
D
A
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Q
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A
I
A
K
L
L
R
F
---
A
S
-
T
--
H
T
DSS
A
Q
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
-------
K
-
V
--
D
E
S
L
E
K
L
--
A
------
K
E
-------
A
E
K
A
------
L
T
P
F
I
D
R
V
K
A
-
L
-
L
G
E
R
V
K
D
V
R
L
T
H
R
L
T
-
D
T
P
A
I
V
S
T
D
---
A
---------------------------------------------------------
K
Y
I
F
E
L
N
P
D
H
V
L
V
K
R
A
--
A
D
----
T
----
E
D
-----
E
-----
A
K
F
S
E
W
V
E
L
L
L
D
Q
A
L
L
A
E
R
G
T
L
E
D
P
N
L
F
I
R
R
M
N
Q
L
L
V
S
----
24
PsiBlast_CBE
89.00
36%
-84
- C2 -
2O1V
3
ENPL_CANFA
B:
[36-659]
-----------------
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
-
E
N
A
L
A
G
N
E
E
L
-
T
--
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
--
N
D
-
T
--
Q
--
H
I
W
E
S
D
S
N
E
F
S
V
I
A
-
D
P
---
R
---
G
N
T
LG
R
--
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
----------------
F
I
N
F
P
I
Y
V
W
S
S
K
T
-----------
V
W
D
-----
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
----------
Y
----
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
-
M
I
K
K
I
A
-
D
-
E
-
K
Y
N
-
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
--
E
D
H
S
N
--
R
T
R
L
A
K
L
L
R
F
---
Q
S
-
S
H-
H
P
---
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
KEGV
K
F
D
E
-
S
--
E
K
T
K
-------
E
--
S
R
E
A
-------
I
E
K
E
------
F
E
P
L
L
N
W
M
K
D
-
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
---
C
A
L
V
---
A
S
Q
YGWS
G
N
M
--
E
R
I
M
K
A
Q
A
Y
--
Q
T
-
G
K
---------
D
--------
I
STNYY
A
S
Q
---
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
--
L
R
----
R
V
K
E
D
E
D
-----
D
-----
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
--
25
PsiBlast_CBE
88.35
36%
-83
- C2 -
2O1U
3
?
B:
[36-659]
-----------------
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
-
E
N
A
L
A
G
N
E
E
L
-
T
--
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
--
N
D
-
T
--
Q
--
H
I
W
E
S
D
S
N
E
F
S
V
I
A
-
D
P
---
R
---
G
N
T
LG
R
--
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
----------------
F
I
N
F
P
I
Y
V
W
S
S
K
T
-----------
V
W
D
-----
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
----------
Y
----
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
-
M
I
K
K
I
A
-
D
-
E
-
K
Y
N
-
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
--
E
D
H
S
N
--
R
T
R
L
A
K
L
L
R
F
---
Q
S
-
S
H-
H
P
---
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
KE
G
V
K
F
D
E
-
S
--
E
K
T
K
-------
E
--
S
R
E
A
-------
I
E
K
E
------
F
E
P
L
L
N
W
M
K
D
-
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
---
C
A
L
V
---
A
S
Q
YGWS
G
N
M
--
E
R
I
M
K
A
Q
A
Y
--
Q
T
-
G
K
---------
D
--------
I
STNYY
A
S
Q
---
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
--
L
R
----
R
V
K
E
D
E
D
-----
D
-----
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
--
6
PsiBlast_PDB
86.02
36%
-79
- C2 -
2O1V
3
ENPL_CANFA
A:
[34-659]
---------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
-
E
N
A
L
A
G
N
E
E
L
-
T
--
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
--
N
D
-
T
--
Q
--
H
I
W
E
S
D
S
N
E
F
S
V
I
A
-
D
P
---
R
---
G
N
T
LG
R
--
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
----------------
F
I
N
F
P
I
Y
V
W
S
S
K
------------
V
W
D
-----
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
--
R
------
Y
----
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
-
M
I
K
K
I
A
-
D
-
E
-
K
Y
N
-
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
--
E
D
H
S
N
--
R
T
R
L
A
K
L
L
R
F
---
Q
S
-
S
H-
H
P
---
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
KE
G
V
K
F
D
E
-
S
--
E
K
T
K
-------
E
--
S
R
E
A
-------
I
E
K
E
------
F
E
P
L
L
N
W
M
K
D
-
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
---
C
A
L
V
---
A
S
Q
YGWS
G
N
M
--
E
R
I
M
K
A
Q
A
Y
--
Q
T
-
G
K
---------
D
--------
I
STNYY
A
S
Q
---
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
--
L
R
----
R
V
K
E
D
E
D
-----
D
-----
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
--
5
PsiBlast_PDB
85.79
36%
-79
- C2 -
2O1U
3
?
A:
[34-659]
---------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
-
E
N
A
L
A
G
N
E
E
L
-
T
--
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
--
N
D
-
T
--
Q
--
H
I
W
E
S
D
S
N
E
F
S
V
I
A
-
D
P
---
R
---
G
N
T
LG
R
--
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
----------------
F
I
N
F
P
I
Y
V
W
S
S
K
------------
V
W
D
-----
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
--
R
------
Y
----
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
-
M
I
K
K
I
A
-
D
-
E
-
K
Y
N
-
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
--
E
D
H
S
N
--
R
T
R
L
A
K
L
L
R
F
---
Q
S
-
S
H-
H
P
---
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
KEGVKFD
E
-
S
--
E
K
T
K
-------
E
--
S
R
E
A
-------
I
E
K
E
------
F
E
P
L
L
N
W
M
K
D
-
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
---
C
A
L
V
---
A
S
Q
YGWS
G
N
M
--
E
R
I
M
K
A
Q
A
Y
--
Q
T
-
G
K
---------
D
--------
I
STNYY
A
S
Q
---
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
--
L
R
----
R
V
K
E
D
E
D
-----
D
-----
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
--
123
Fugue
85.18
37%
-75
- C2 -
2O1U
3
?
A:
[34-661]
---------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
-
E
N
A
L
A
G
N
E
E
L
-
T
--
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
--
N
D
-
T
--
Q
--
H
I
W
E
S
D
S
N
E
F
S
V
I
A
-
D
P
---
R
---
G
N
T
--
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
----------------
F
I
N
F
P
I
Y
V
W
S
S
--------------
K
V
---
W
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
--
R
----------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
-
M
I
K
K
I
A
-
D
-
E
-
K
Y
N
-
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
--
E
D
H
S
N
--
R
T
R
L
A
K
L
L
R
F
---
Q
S
S
H
--
H
P
---
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
-------
K
-
E
GV
K
F
D
E
S
E
K
--
T
K
E
--
S
R
E
A
-------
I
E
K
E
------
F
E
P
L
L
N
W
M
K
D
-
K
A
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
E
S
P
---
C
A
L
V
---
A
S
Q
------
Y
GW
S
G
N
M
E
R
I
M
K
--
A
Q
-
A
Y
Q
TGKDISTN
Y
--------
Y
-----
A
S
Q
---
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
--
L
R
R
V
K
E
D
----
E
D
-----
D
-----
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
NI
26
PsiBlast_CBE
85.06
34%
-77
- C3 -
4J0B
4
?
B:
[31-644]
-----
H
E
-
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
G
S
D
A
L
E
K
L
R
H
R
M
I
T
-----
A
G
---
A
P
M
E
--
I
H
L
Q
T
D
S
V
K
G
T
F
T
I
Q
D
T
G
V
G
M
N
K
E
D
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
Q
-----
S
S
S
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
K
V
E
V
Y
S
Q
S
A
--
E
A
D
A
--
P
-
G
Y
K
W
S
S
D
G
S
G
V
F
E
V
A
-
E
A
---
S
---
G
V
R
--
Q
--
G
T
K
I
V
L
H
L
K
D
D
C
K
E
F
S
S
E
D
R
V
K
E
V
V
T
K
Y
S
N
----------------
F
V
S
F
P
I
F
L
N
-----------------------
G
R
R
L
N
T
L
Q
A
L
W
M
M
E
P
K
D
I
S
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
Y
D
K
P
R
Y
T
L
H
Y
R
A
D
A
P
L
N
I
R
S
I
F
Y
V
P
E
M
K
P
S
M
F
D
V
S
R
-
E
M
---
S
V
A
L
Y
S
R
K
I
L
I
Q
T
K
--
D
I
L
P
K
W
L
R
F
L
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
V
I
R
F
L
L
D
Q
S
K
K
D
-
P
-
E
K
Y
-
A
R
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
T
G
E
Q
S
V
--
K
E
D
I
A
K
L
L
R
F
---
E
S
-
S
AL
P
A
---
G
Q
Q
T
S
L
M
E
Y
S
S
R
M
K
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
F
E
A
M
K
Q
K
D
M
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
R
K
K
L
I
S
A
E
-------
T
-
D
--
I
V
V
D
H
Y
K
--
E
E
K
--
F
Q
D
S
KPASERL
S
S
E
Q
------
A
E
D
L
L
A
W
M
R
N
-
A
-
L
V
Q
R
V
T
N
I
K
V
T
P
R
L
D
-
T
H
---
P
A
M
I
---
T
V
L
------
E
--
M
G
A
A
R
H
F
L
R
T---------------------------------IL-
Q
P
T
L
E
I
N
T
G
H
D
L
I
K
K
L
H
A
L
K
----
D
----
S
N
-----
P
-----
E
L
A
Q
L
L
L
E
Q
I
Y
D
N
A
-
M
I
A
A
G
L
N
E
D
P
R
P
M
I
S
R
L
N
Q
L
L
T
R
A
L
--
8
PsiBlast_PDB
83.50
34%
-75
- C3 -
4J0B
4
?
A:
[31-644]
-----
H
E
-
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
G
S
D
A
L
E
K
L
R
H
R
M
I
T
-----
A
G
G
D
T
A
P
M
E
--
I
H
L
Q
T
D
S
V
K
G
T
F
T
I
Q
D
T
G
V
G
M
N
K
E
D
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
Q
N
Q
A
E
A
S
S
S
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
K
V
E
V
Y
S
Q
S
A
--
E
A
D
A
--
P
-
G
Y
K
W
S
S
D
G
S
G
V
F
E
V
A
-
E
A
---
S
---
G
V
R
--
Q
--
G
T
K
I
V
L
H
L
K
D
D
C
K
E
F
S
S
E
D
R
V
K
E
V
V
T
K
Y
S
N
----------------
F
V
S
F
P
I
F
L
N
-----------------------
G
R
R
L
N
T
L
Q
A
L
W
M
M
E
P
K
D
I
S
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
Y
D
K
P
R
Y
T
L
H
Y
R
A
D
A
P
L
N
I
R
S
I
F
Y
V
P
E
M
K
P
---------
M
G
-
S
S
V
A
L
Y
S
R
K
I
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
L
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
V
I
R
F
L
L
D
Q
S
K
K
D
-
P
-
E
K
Y
-
A
R
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
T
T
G
E
Q
S
V
--
K
E
D
I
A
K
L
L
R
F
---
E
S
-
S
AL
P
A
---
G
Q
Q
T
S
L
M
E
Y
S
S
R
M
K
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
F
E
A
M
K
--
D
M
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
R
K
K
L
I
S
A
E
-------
T
----------------------RL-----
S
S
E
Q
------
A
E
D
L
L
A
W
M
R
N
-
A
-
L
V
Q
R
V
T
N
I
K
V
T
P
R
L
D
-
T
H
---
P
A
M
I
---
T
V
L
------
E
--
M
G
A
A
R
H
F
L
R
TQ--------------------------------QI
L
Q
P
T
L
E
I
N
T
G
H
D
L
I
K
K
L
H
A
L
K
----
D
----
S
N
-----
P
-----
E
L
A
Q
L
L
L
E
Q
I
Y
D
N
A
-
M
I
A
A
G
L
N
E
D
P
R
P
M
I
S
R
L
N
Q
L
L
T
R
A
L
--
102
HHSearch
82.41
36%
-72
- C2 -
2O1U
3
?
A:
[34-659]
---------------
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
-
E
N
A
L
A
G
N
E
E
L
-
T
--
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
--
N
D
----
T
-
Q
H
I
W
E
S
D
S
-
N
E
F
S
V
I
-
A
D
PRG
N
---
T
L
G
--
R
--
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
----------------
F
I
N
F
P
I
Y
V
W
S
S
K
--------------
V
---
W
D
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
--
R
----------
Y
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
-
M
I
K
K
I
A
D
----
E
K
Y
N
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
--
E
D
H
S
N
--
R
T
R
L
A
K
L
L
R
F
---
Q
S
-
S
--
H
H
P--
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
-------
K
-
E
--
G
V
K
F
D
E
S
--
E
K
T
K
E
S
R
E
A
-------
I
E
K
E
------
F
E
P
L
L
N
W
M
K
D
K
A
-
L
K
D
K
I
E
K
A
V
V
S
Q
R
L
T
-
E
S
P
C
A
L
V
A
S
---
Q
Y
G
------
W
--
S
G
N
M
E
R
I
M
K
--
A
Q
-
A
Y
Q
--------
T
GKDISTNY
Y
-----
A
S
Q
---
K
K
T
F
E
I
N
P
R
H
P
L
I
K
D
M
--
L
R
----
R
----
V
K
-----
E
DEDD-
K
T
V
S
D
L
A
V
V
L
F
E
T
A
T
L
R
S
G
Y
L
L
P
D
T
K
A
Y
G
D
R
I
E
R
M
L
R
L
S
L
--
103
HHSearch
79.33
39%
-63
- C3 -
2CG9
1
HSP82_YEAST
A:
[2-676]
-
A
S
E
T
F
E
-
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
-
P
K
Q
L
E
T
E
P
D
L
-
F
--
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
A
--
G
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
--
D
D
----
E
-
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
-
L
D
---
E
VNE
R
I
G
--
R
--
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
----------------
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
K
E
-------
E
E
V
---
Q
E
I
E
E
L
N
K
T
K
P
L
W
T
R
N
P
S
D
I
T
Q
E
E
Y
N
A
F
Y
K
S
I
S
N
D
W
E
D
P
L
Y
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
I
L
F
I
P
K
R
A
P
--
F
---------
N
N
I
K
L
Y
V
R
R
V
F
I
T
D
E
A
E
D
L
I
P
E
W
L
S
F
V
K
G
V
V
D
S
E
D
L
P
L
N
L
S
R
E
M
L
Q
Q
N
K
I
M
K
V
I
R
K
N
I
V
K
K
L
I
E
-
A
F
N
E
I
A
E
D
-
S
-
E
Q
F
-
E
K
F
Y
S
A
F
S
K
N
I
K
L
G
V
H
--
E
D
T
Q
N
--
R
A
A
L
A
K
L
L
R
Y
---
N
S
-
T
--
K
S
V--
D
E
L
T
S
L
T
D
Y
V
T
R
M
P
E
H
Q
K
N
I
Y
Y
I
T
G
E
S
L
K
A
V
E
K
S
P
F
L
D
A
L
K
A
K
N
F
E
V
L
F
L
T
D
P
I
D
E
Y
A
F
T
Q
L
K
E
F
E
G
K
T
L
V
D
I
T
-------
K
-
D
---
F
E
L
E
E
T
--
D
E
E
K
A
E
R
E
K
-------
E
I
K
E
------
Y
E
P
L
T
K
A
L
K
E
-
I
-
L
G
D
Q
V
E
K
V
V
V
S
Y
K
L
L
-
D
A
P
A
A
I
R
T
G
---
Q
F
G
------
W
--
S
A
N
M
E
R
I
M
K
--
A
Q
-
A
--------------------------------
K
T
F
E
I
S
P
K
S
P
I
I
K
E
L
--
K
K
----
R
----
V
D
EGGAQ
D
-----
K
T
V
K
D
L
T
K
L
L
Y
E
T
A
L
L
T
S
G
F
S
L
D
E
P
T
S
F
A
S
R
I
N
R
L
I
S
L
G
L
--
2
PsiBlast_PDB
79.03
46%
-75
- C2 -
1Y4S
2
HTPG_ECOLI
A:
[1-483]
M
K
G
Q
E
T
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
-
P
D
L
Y
E
G
D
G
E
L
-
R
--
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
--------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
GE
K
P
-
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
-
D
I
---
T
---
K
E
D
--
R
--
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
----------------
H
I
A
L
P
V
E
I
E
K
R
E
E
K
-----
D
G
E
T
V
I
S
W
---
E
K
---
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
N
R
D
H
K
-
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
-
M
L
E
K
L
A
K
D
-
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
--
E
D
F
A
N
--
Q
E
A
I
A
K
L
L
R
F
A
S
T
H
T
-
D
--
S
S
---
A
Q
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.69
46%
-77
- C2 -
1Y4U
-
HTPG_ECOLI
A:
[1-489]
M
K
G
Q
E
T
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
-
P
D
L
Y
E
G
D
G
E
L
-
R
--
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
-----------------
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
GE
K
P
-
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
-
D
I
---
T
---
K
E
D
--
R
--
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
----------------
H
I
A
L
P
V
E
I
E
K
R
E
E
K
-----
D
G
E
T
V
I
S
W
---
E
K
---
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
N
R
D
H
K
-
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
-
M
L
E
K
L
A
K
D
-
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
--
E
D
F
A
N
--
Q
E
A
I
A
K
L
L
R
F
AST
H
T
-
D
--
S
S
---
A
Q
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
S
-------
K
V
D
--
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.25
40%
-79
- C2 -
2O1W
-
?
A:
[95-592]
-------------------------
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
-
E
N
A
L
A
G
N
E
E
L
-
T
--
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
----------------------------
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
--
N
D
-
T
--
Q
--
H
I
W
E
S
D
S
N
E
F
S
V
I
A
-
D
P
---
R
---
G
N
T
LG
R
--
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
----------------
F
I
N
F
P
I
Y
V
W
S
S
K
T
---------
K
T
V
W
D
-----
W
E
L
M
N
D
I
K
P
I
W
Q
R
P
S
K
E
V
E
D
D
E
Y
K
A
F
Y
K
S
F
S
K
E
S
D
D
P
M
A
Y
I
H
F
T
A
E
G
E
V
T
F
K
S
I
L
F
V
P
T
S
A
P
--
R
------
Y
----
I
K
L
Y
V
R
R
V
F
I
T
D
D
F
H
D
M
M
P
K
Y
L
N
F
V
K
G
V
V
D
S
D
D
L
P
L
N
V
S
R
E
T
L
Q
Q
H
K
L
L
K
V
I
R
K
K
L
V
R
K
T
L
D
-
M
I
K
K
I
A
-
D
-
E
-
K
Y
N
-
D
T
F
W
K
E
F
G
T
N
I
K
L
G
V
I
--
E
D
H
S
N
--
R
T
R
L
A
K
L
L
R
F
---
Q
S
-
S
H-
H
P
---
S
D
I
T
S
L
D
Q
Y
V
E
R
M
K
E
K
Q
D
K
I
Y
F
M
A
G
S
S
R
K
E
A
E
S
S
P
F
V
E
R
L
L
K
K
G
Y
E
V
I
Y
L
T
E
P
V
D
E
Y
C
I
Q
A
L
P
E
F
D
G
K
R
F
Q
N
V
A
-------
K
-
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.04
37%
-65
- C3 -
2CG9
1
HSP82_YEAST
B:
[2-672]
-
A
S
E
T
F
E
-
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
-
P
K
--
Q
L
E
T
E
P
-
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
A
G
A
--
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
--
D
D
-
E
--
Q
--
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
---
V
---
N
E
R
IG
R
--
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
FVAYPI
Q
L
V
V
T
K
E
VEK
E
--------------------------EEV
Q
E
I
E
E
L
N
K
T
K
P
L
W
T
R
N
P
S
D
I
T
Q
E
E
Y
N
A
F
Y
K
S
I
S
N
D
W
E
D
P
L
Y
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
I
L
F
I
P
K
R
A
P
--
F
D
L
F
E
S
K
K
K
K
N
N
I
K
L
Y
V
R
R
V
F
I
T
D
E
A
E
D
L
I
P
E
W
L
S
F
V
K
G
V
V
D
S
E
D
L
P
L
N
L
S
R
E
M
L
Q
Q
N
K
I
M
K
V
I
R
K
N
I
V
K
K
L
I
E
-
A
F
N
E
I
A
E
D
-
S
-
E
Q
F
-
E
K
F
Y
S
A
F
S
K
N
I
K
L
G
V
H
--
E
D
T
Q
N
--
R
A
A
L
A
K
L
L
R
Y
---
N
S
T
K
--
S
V
---
D
E
L
T
S
L
T
D
Y
V
T
R
M
P
E
H
Q
K
N
I
Y
Y
I
T
G
E
S
L
K
A
V
E
K
S
P
F
L
D
A
L
K
A
K
N
F
E
V
L
F
L
T
D
P
I
D
E
Y
A
F
T
Q
L
K
E
F
E
G
K
T
L
V
D
I
T
-------
K
-
D
--
F
E
L
E
E
T
D
E
E
K
A
E
--
R
E
K
E
-------
I
K
-
E
------
Y
E
P
L
T
K
A
L
K
E
-
I
-
L
G
D
Q
V
E
K
V
V
V
S
Y
K
L
L
-
D
A
---
P
A
A
I
---
R
T
G
------
Q
--
F
G
W
S
A
N
M
E
R
--
I
M
K
A
Q
---------
A
---------------------
K
T
F
E
I
S
P
K
S
P
I
I
K
E
L
--
K
K
----
R
----
V
D
-----
E
GGAQD
K
T
V
K
D
L
T
K
L
L
Y
E
T
A
L
L
T
S
G
F
S
L
D
E
P
T
S
F
A
S
R
I
N
R
L
I
S
L
G
L
--
108
HHSearch
77.96
47%
-76
- C2 -
1Y4S
2
HTPG_ECOLI
A:
[3-483]
-
G
Q
E
T
R
G
-
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
-
P
D
L
Y
E
G
D
G
E
L
-
R
--
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
--------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
--
G
E
-
K
PE
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
-
D
I
---
T
---
K
E
D
--
R
--
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
----------------
H
I
A
L
P
V
E
I
E
K
R
E
E
K
D
--------
G
E
T
V
---
I
S
W
E
K
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
N
R
D
H
K
-
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
-
M
L
E
K
L
A
K
D
D
A
-
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
--
E
D
F
A
N
--
Q
E
A
I
A
K
L
L
R
F
---
A
S
-
T
--
H
T
DSS
A
Q
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.81
37%
-66
- C3 -
2CG9
1
HSP82_YEAST
A:
[2-672]
-
A
S
E
T
F
E
-
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
-
P
K
--
Q
L
E
T
E
P
-
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
A
G
A
--
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
--
D
D
-
E
--
Q
--
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
---
V
---
N
E
R
IG
R
--
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
FVAYPI
Q
L
V
V
T
K
E
V
E
K
E
--------------------------EEV
Q
E
I
E
E
L
N
K
T
K
P
L
W
T
R
N
P
S
D
I
T
Q
E
E
Y
N
A
F
Y
K
S
I
S
N
D
W
E
D
P
L
Y
V
K
H
F
S
V
E
G
Q
L
E
F
R
A
I
L
F
I
P
K
R
A
P
--
F
---------
N
N
I
K
L
Y
V
R
R
V
F
I
T
D
E
A
E
D
L
I
P
E
W
L
S
F
V
K
G
V
V
D
S
E
D
L
P
L
N
L
S
R
E
M
L
Q
Q
N
K
I
M
K
V
I
R
K
N
I
V
K
K
L
I
E
-
A
F
N
E
I
A
E
D
-
S
-
E
Q
F
-
E
K
F
Y
S
A
F
S
K
N
I
K
L
G
V
H
--
E
D
T
Q
N
--
R
A
A
L
A
K
L
L
R
Y
---
N
S
T
K
--
S
V
---
D
E
L
T
S
L
T
D
Y
V
T
R
M
P
E
H
Q
K
N
I
Y
Y
I
T
G
E
S
L
K
A
V
E
K
S
P
F
L
D
A
L
K
A
K
N
F
E
V
L
F
L
T
D
P
I
D
E
Y
A
F
T
Q
L
K
E
F
E
G
K
T
L
V
D
I
T
-------
K
-
D
--
F
E
L
E
E
T
D
E
E
K
A
E
--
R
E
K
E
-------
I
K
-
E
------
Y
E
P
L
T
K
A
L
K
E
-
I
-
L
G
D
Q
V
E
K
V
V
V
S
Y
K
L
L
-
D
A
---
P
A
A
I
---
R
T
G
------
Q
--
F
G
W
S
A
N
M
E
R
--
I
M
K
A
Q
---------
A
---------------------
K
T
F
E
I
S
P
K
S
P
I
I
K
E
L
--
K
K
----
R
----
V
D
-----
E
GGAQD
K
T
V
K
D
L
T
K
L
L
Y
E
T
A
L
L
T
S
G
F
S
L
D
E
P
T
S
F
A
S
R
I
N
R
L
I
S
L
G
L
--
22
PsiBlast_CBE
77.71
46%
-76
- C2 -
1Y4S
2
HTPG_ECOLI
B:
[1-483]
M
K
G
Q
E
T
R
G
F
Q
S
E
V
K
Q
L
L
H
L
M
I
H
S
L
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
A
D
K
L
R
F
R
A
L
S
N
-
P
D
L
Y
E
G
D
G
E
L
-
R
--
V
R
V
S
F
D
K
D
K
R
T
L
T
I
S
D
N
G
V
G
M
T
R
D
E
V
I
D
H
L
G
T
I
A
K
S
G
T
K
S
F
L
E
S
--------
S
Q
L
I
G
Q
F
G
V
G
F
Y
S
A
F
I
V
A
D
K
V
T
V
R
T
R
A
A
GE
K
P
-
E
--
N
-
G
V
F
W
E
S
A
G
E
G
E
Y
T
V
A
-
D
I
---
T
---
K
E
D
--
R
--
G
T
E
I
T
L
H
L
R
E
G
E
D
E
F
L
D
D
W
R
V
R
S
I
I
S
K
Y
S
D
----------------
H
I
A
L
P
V
E
I
E
K
R
E
E
K
-----
D
G
E
T
V
I
S
W
---
E
K
---
I
N
K
A
Q
A
L
W
T
R
N
K
S
E
I
T
D
E
E
Y
K
E
F
Y
K
H
I
A
H
D
F
N
D
P
L
T
W
S
H
N
R
V
E
G
K
Q
E
Y
T
S
L
L
Y
I
P
S
Q
A
P
--
W
D
M
W
N
R
D
H
K
-
H
G
L
K
L
Y
V
Q
R
V
F
I
M
D
D
A
E
Q
F
M
P
N
Y
L
R
F
V
R
G
L
I
D
S
S
D
L
P
L
N
V
S
R
E
I
L
Q
D
S
T
V
T
R
N
L
R
N
A
L
T
K
R
V
L
Q
-
M
L
E
K
L
A
K
D
-
D
A
E
K
Y
-
Q
T
F
W
Q
Q
F
G
L
V
L
K
E
G
P
A
--
E
D
F
A
N
--
Q
E
A
I
A
K
L
L
R
F
AST
H
T
-
D
--
S
S
---
A
Q
T
V
S
L
E
D
Y
V
S
R
M
K
E
G
Q
E
K
I
Y
Y
I
T
A
D
S
Y
A
A
A
K
S
S
P
H
L
E
L
L
R
K
K
G
I
E
V
L
L
L
S
D
R
I
D
E
W
M
M
N
Y
L
T
E
F
D
G
K
P
F
Q
S
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
74.05
36%
-78
- C3 -
4Z1I
2
TRAP1_HUMAN
C:
[25-485]
-
S
T
S
K
H
E
-
F
Q
A
E
T
K
K
L
L
D
I
V
A
R
S
L
Y
S
E
K
E
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
H
K
L
V
S
D
G
Q
A
L
P
E
M
E
-------
I
H
L
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
I
G
M
T
Q
E
E
L
V
S
N
L
G
T
I
A
R
S
G
S
K
A
F
L
D
A
L
---
A
E
A
S
S
K
I
I
G
Q
F
G
V
G
F
Y
S
A
F
M
V
A
D
R
V
E
V
Y
S
R
S
A
--
A
P
-
G
--
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
I
A
-
E
A
---
S
---
G
V
R
--
T
--
G
T
K
I
I
I
H
L
K
S
D
C
K
E
F
S
S
E
A
R
V
R
D
V
V
T
K
Y
S
N
----------------
F
V
S
F
P
L
Y
L
N
-----------------------
G
R
R
M
N
T
L
Q
A
I
W
M
M
D
P
K
D
V
R
E
W
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
------------
S
S
V
A
L
Y
S
R
K
V
L
I
Q
T
K
A
T
D
I
L
P
K
W
L
R
F
I
R
G
V
V
D
S
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
D
V
L
Q
Q
R
L
I
K
F
F
I
D
Q
S
K
K
D
-
A
-
E
K
Y
-
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
I
V
--
T
A
T
E
Q
E
V
K
E
D
I
A
K
L
L
R
Y
---
E
S
-
S
AL
P
S
---
G
Q
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
D
K
K
K
L
I
S
V
E
-------
T
-
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------