@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0202: (2015-12-13 )
MVVLGSTGSIGKNALKIAKKFGVKIEALSCGKNIALINEQIKVFKPKKVAILDPNDLNNLEPLGAEVFVGLDGIDAMIEECVSNLVINAIVGVAGLKASFKSLQRNKKLALANKESLVSAGHLLDISQITPVDSEHFGLWALLQNKTLKPKSLIISASGGAFRDTPLDLIAIQNAQNALKHPNWSMGDKITIDSASMVNKLFEILETYWLFGASLKIDALIERSSIVHALVEFEDNSVIAHLASADMQLPISYAINPKLASLSASIKPLDLYALSAIKFEPISVERYTLWRYKDLLLENPKLGVVLNASNEVAMKKFLNQEIAFGGFIQIISQALELYAKKSFKLSSLDEVLALDKEVRERFGSVARV
Atome Classification :
(63 SA)
.........10........20-.--.-----.......30........40........50........60.-..------.....----.70........80.--.......90..---......100.......110.......120---...------..------...130....--------------...140.-....-----------..-150..-------------......160..-.....170.......180.......190.......200.......210...-.-...220.......230.......240.......250...-.-...260.......270.......280.....-..290-.-.-......300..----......310.......320.......330.......340..-.....350.......360......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
V
LGSTGSI
G
K
N
A
L
K
I
A
K
K--F--G-----
V
K
I
E
A
LSCGK
N
I
A
L
INE
Q
I
K
V
FKP
K
K
V
A
I
LDPNDLNNL-E-PL------G
A
E
V
F
----
V
GLD
G
I
D
A
M
I
E
E
C
V
--
S
N
L
V
I
N
A
I
V
G
V---A
G
L
K
A
S
F
K
S
L
QRNK
K
L
ALA
N
K
E
S
L
VSAG----
H
L
L
------
D
I
------SQITPVDSEH--------------
F
G
L
W
A
L
L-QNKT-----------LK-P-
K
S
L
-------------
I
I
SASGGAFRD-TP
L
D
L
I
A
IQN
A
Q
N
A
LKHPNWSMG
D
K
I
T
I
D
S
A
S
M
V
N
K
L
F
E
I
L
E
T
Y
W
LFGAS
L
-
K
-
I
D
A
L
I
E
R
S
S
I
V
H
A
L
V
EFEDN
S
V
I
A
H
LASA
D
M
Q
L
P
I
S
Y
AI-N-P
K
L
A
S
LSASIK
P
L
D
L
Y
A
L
S
A
I
K
FEP
I
S
VE
R
Y
-
T
L
W
R
--
Y
-
K
-
D
L
L
LENPK-
L
G
----
V
V
L
NAS
N
E
V
A
M
K
K
F
L
N
QEIA
F
G
G
F
I
Q
I
I
S
Q
A
L
E
L
Y
A
K
KSFK-
L
S
S
L
D
E
V
L
A
L
D
K
E
V
R
E
R
F
G
S
VARV
21
PsiBlast_CBE
91.51
35%
-98
- C6 -
1R0L
1
DXR_ZYMMO
D:
[7-376]
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
--
N
LD
R
-----
Y
Q
V
I
A
L
T
A
N
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
-
A
L
------
A
G
S
S
V
----
E
A
A
A
G
A
D
A
L
V
E
A
A
M
MG
A
D
W
T
M
A
A
I
I
G
C
---
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
----
G
L
M
IDAVRE
H
G
------
T
T
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
C
F
-
P
H
H
N
-----------
R
D
Y
V
-
R
R
I
-------------
I
I
T
A
S
G
G
P
F
R
T
-
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
H
------
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
-
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
-
A
W
P
K
--
R
M
E
T
P
A
E
S
L
D
F
T
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
-
P
A
L
-------
T
L
A
M
E
S
I
K
-
S
G
GARP
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
---
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
E
S
2
PsiBlast_PDB
90.83
35%
-98
- C6 -
1R0L
1
DXR_ZYMMO
A:
[7-376]
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
--
N
LD
R
-----
Y
Q
V
I
A
L
T
A
N
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
-
A
L
------
A
G
S
S
V
----
E
A
A
A
G
A
D
A
L
V
E
A
A
M
MG
A
D
W
T
M
A
A
I
I
G
C
---
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
----
G
L
M
I
D
A
V
R
E
H
G
------
T
T
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
C
F
-
P
H
H
N
-----------
R
D
Y
V
-
R
R
I
-------------
I
I
T
A
S
G
G
P
F
R
T
-
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
------
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
-
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
-
A
W
P
K
--
R
M
E
T
P
A
E
S
L
D
F
T
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
-
P
A
L
-------
T
L
A
M
E
S
I
K
-
S
G
GA
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
---
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
E
S
1
PsiBlast_PDB
90.69
35%
-98
- C6 -
1R0K
1
DXR_ZYMMO
A:
[7-376]
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
--
N
LD
R
-----
Y
Q
V
I
A
L
T
A
N
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
-
A
L
------
A
G
S
S
V
----
E
A
A
A
G
A
D
A
L
V
E
A
A
M
MG
A
D
W
T
M
A
A
I
I
G
C
---
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
----
G
L
M
I
D
A
V
R
E
H
G
------
T
T
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
C
F
-
P
H
H
N
-----------
R
D
Y
V
-
R
R
I
-------------
I
I
T
A
S
G
G
P
F
R
T
-
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
------
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
-
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
-
A
W
P
K
--
R
M
E
T
P
A
E
S
L
D
F
T
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
-
P
A
L
-------
T
L
A
M
E
S
I
K
-
S
G
GA
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
---
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
E
S
24
PsiBlast_CBE
90.50
35%
-99
- C6 -
1R0K
1
DXR_ZYMMO
D:
[7-376]
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
--
N
LD
R
-----
Y
Q
V
I
A
L
T
A
N
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
-
A
L
------
A
G
S
S
V
----
E
A
A
A
G
A
D
A
L
V
E
A
A
M
MG
A
D
W
T
M
A
A
I
I
G
C
---
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
----
G
L
M
I
D
A
V
R
E
H
G
------
T
T
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
C
F
-
P
H
H
N
-----------
R
D
Y
V
-
R
R
I
-------------
I
I
T
A
S
G
G
P
F
R
T
-
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
H
P
---
M
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
-
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
-
A
W
P
K
--
R
M
E
T
P
A
E
S
L
D
F
T
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
-
P
A
L
-------
T
L
A
M
E
S
I
K
-
S
G
GA
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
---
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
E
S
26
PsiBlast_CBE
89.91
35%
-98
- C6 -
1R0K
1
DXR_ZYMMO
B:
[7-376]
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
--
N
L
D
R
-----
Y
Q
V
I
A
L
T
A
N
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
-
A
L
------
A
G
S
S
V
----
E
A
A
A
G
A
D
A
L
V
E
A
A
M
MG
A
D
W
T
M
A
A
I
I
G
C
---
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
----
G
L
M
I
D
A
V
R
E
H
G
------
T
T
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
C
F
-
P
H
H
N
-----------
R
D
Y
V
-
R
R
I
-------------
I
I
T
A
S
G
G
P
F
R
T
-
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
H
P
--
S
M
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
-
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
-
A
W
P
K
--
R
M
E
T
P
A
E
S
L
D
F
T
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
-
P
A
L
-------
T
L
A
M
E
S
I
K
-
S
G
GA
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
---
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
E
S
23
PsiBlast_CBE
89.47
35%
-97
- C6 -
1R0L
1
DXR_ZYMMO
B:
[7-376]
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
--
N
LD
R
-----
Y
Q
V
I
A
L
T
A
N
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
-
A
L
------
A
G
S
S
V
----
E
A
A
A
G
A
D
A
L
V
E
A
A
M
MG
A
D
W
T
M
A
A
I
I
G
C
---
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
----
G
L
M
I
D
A
V
R
E
H
G
------
T
T
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
C
F
-
P
H
H
N
-----------
R
D
Y
V
-
R
R
I
-------------
I
I
T
A
S
G
G
P
F
R
T
-
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
H
P
-----
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
-
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
-
A
W
P
K
--
R
M
E
T
P
A
E
S
L
D
F
T
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
-
P
A
L
-------
T
L
A
M
E
S
I
K
-
S
G
GA
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
---
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
E
S
22
PsiBlast_CBE
88.58
35%
-99
- C6 -
1R0L
1
DXR_ZYMMO
C:
[7-376]
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
--
N
LD
R
-----
Y
Q
V
I
A
L
T
A
N
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
-
A
L
------
A
G
S
S
V
----
E
A
A
A
G
A
D
A
L
V
E
A
A
M
MG
A
D
W
T
M
A
A
I
I
G
C
---
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
----
G
L
M
I
D
A
V
R
E
H
G
------
T
T
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
C
F
-
P
H
H
N
-----------
R
D
Y
V
-
R
R
I
-------------
I
I
T
A
S
G
G
P
F
R
T
-
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
--------
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
-
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
-
A
W
P
K
--
R
M
E
T
P
A
E
S
L
D
F
T
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
-
P
A
L
-------
T
L
A
M
E
S
I
K
-
S
G
GA
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
---
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
E
S
25
PsiBlast_CBE
87.86
35%
-98
- C6 -
1R0K
1
DXR_ZYMMO
C:
[7-376]
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
--
N
L
D
R
-----
Y
Q
V
I
A
L
T
A
N
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
K
E
-
A
L
------
A
G
S
S
V
----
E
A
A
A
G
A
D
A
L
V
E
A
A
M
MG
A
D
W
T
M
A
A
I
I
G
C
---
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
----
G
L
M
I
D
A
V
R
E
H
G
------
T
T
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
C
F
-
P
H
H
N
-----------
R
D
Y
V
-
R
R
I
-------------
I
I
T
A
S
G
G
P
F
R
T
-
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
-------
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
-
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
-
A
W
P
K
--
R
M
E
T
P
A
E
S
L
D
F
T
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
-
P
A
L
-------
T
L
A
M
E
S
I
K
-
S
G
GA
R
P
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
A
T
---
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
E
S
20
PsiBlast_PDB
87.26
33%
-90
- C6 -
3R0I
2
DXR_ECOLI
A:
[16-399]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
-----
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
101
HHSearch
86.42
35%
-81
- C6 -
1Q0Q
2
DXR_ECOLI
A:
[12-402]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
T
M
L
Q
Q
Q
GS-
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
------
M
D
A
V
K
Q
S
K
A
Q
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
S
L
-
P
Q
P
I
Q
H
N
LGYADLEQ
N
G
-
V
-
V
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
-
W
P
N
R
V
N
S
G
-
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
-
M
E
A
F
E
Q
G
Q
A
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
--
R
E
-
P
Q
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
103
HHSearch
86.35
35%
-89
- C6 -
1R0K
1
DXR_ZYMMO
A:
[7-384]
V
T
V
L
G
A
T
G
S
I
G
H
S
T
L
D
L
I
E
R
N
L
D
--
R
-----
Y
Q
V
I
A
L
T
A
N
R
N
V
K
D
L
A
D
A
A
K
R
T
N
A
K
R
A
V
I
A
D
P
S
L
Y
N
D
L
-
K
E
A
L
AGS---
S
V
E
A
A
----
A
G
A
D
A
L
V
E
A
-
A
M
M
G
--
A
D
W
T
M
A
A
I
I
G
C
---
A
G
L
K
A
T
L
A
A
I
R
K
G
K
T
V
A
L
A
N
K
E
S
L
V
S
A
G
----
G
L
M
------
I
D
A
V
R
E
H
G
T
T
L
L
P
V
D
S
E
H
--------------
N
A
I
F
Q
C
F
-
P
H
H
N
R----------
D
Y
-
V
-
R
R
I
-------------
I
I
T
A
S
G
G
P
F
R
T
-
T
S
L
A
E
M
A
T
V
T
P
E
R
A
V
Q
------
G
A
K
I
S
I
D
S
A
T
M
M
N
K
G
L
E
L
I
E
A
F
H
L
F
Q
I
P
L
E
K
-
F
E
I
L
V
H
P
Q
S
V
I
H
S
M
V
E
Y
L
D
G
S
I
L
A
Q
I
G
S
P
D
M
R
T
P
I
G
H
T
L
-
A
-
W
P
K
R
M
E
T
P
-
A
E
S
L
D
F
T
K
L
R
Q
M
D
F
E
A
P
D
Y
E
R
F
-
P
A
L
T
--
L
-
A
-
M
E
S
I
K
S
G
G
A
R
P
----
A
V
M
N
A
A
N
E
I
A
V
A
A
F
L
D
K
K
I
G
F
L
D
I
A
K
I
V
E
K
T
L
D
H
Y
T
P
--
A
T
-
P
S
S
L
E
D
V
F
A
I
D
N
E
A
R
I
Q
A
A
A
L
M
E
S
42
PsiBlast_CBE
85.62
33%
-86
- C6 -
3ANL
2
DXR_ECOLI
B:
[14-397]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
--
N
PE
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
LQQQGS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
MDAVKQ
S
K
------
A
Q
L
L
P
V
D
S
E
H
NAIFQSLPQPIQHN
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
43
PsiBlast_CBE
85.46
33%
-88
- C6 -
3R0I
2
DXR_ECOLI
B:
[16-399]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
NP
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
LQQQGS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
MDAVKQ
S
K
------
A
Q
L
L
P
V
D
S
E
H
NAIFQSLPQPIQHN
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
-----
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
16
PsiBlast_PDB
85.22
33%
-84
- C6 -
3ANL
2
DXR_ECOLI
A:
[14-397]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
--
N
PE
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
14
PsiBlast_PDB
85.22
35%
-99
- C6 -
3A06
4
DXR_THEMA
A:
[6-341]
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
K
K
--
V
K-
G
-----
I
R
L
I
G
I
S
F
H
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
--
G
D
V
E
-
F
-
E
-
D
S
------
S
I
N
V
W
----
K
G
S
H
S
I
E
E
M
L
E
A
L
K
--
P
D
I
T
M
V
A
V
S
G
F
---
S
G
L
R
A
V
L
A
S
L
E
H
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
----
F
L
V
------
K
K
K
L
K
E
K
G
T
E
L
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
V
M
-
E
P
E
V
-----------
E
K
-----
V
-------------
V
L
T
A
S
G
G
A
L
R
D
-
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
-
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
-
P
R
R
V
A
L
----
E
P
F
F
L
R
T
I
S
-
L
S
F
E
D
P
D
P
E
K
Y
-
P
A
F
F
--
L
-
L
-
K
E
I
K
D
S
Y
A
-
L
R
----
T
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P
Q
P
-
R
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
E
R
V
T
E
W
L
104
HHSearch
85.14
34%
-89
- C6 -
3A06
4
DXR_THEMA
A:
[6-369]
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
K
K
V-
K
--
G
-----
I
R
L
I
G
I
S
F
H
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
G
D
V
E
F
E
D
S
-----------
S
I
N
V
W
----
K
G
S
H
S
I
E
E
M
L
E
A
L
K
--
P
D
I
T
M
V
A
V
S
G
F
---
S
G
L
R
A
V
L
A
S
L
E
H
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
----
F
L
V
------
K
K
K
L
K
E
K
G
T
E
L
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
V
M
-
E
P
--------------
E
-
V
-
E
K
V
-------------
V
L
T
A
S
G
G
A
L
R
D
-
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
-
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
-
F
-
Y
P
R
R
V
A
L
---
E
P
-
F
F
L
R
T
I
S
L
S
F
E
D
P
D
P
E
K
Y
-
P
A
F
F
--
L
-
L
-
K
E
I
K
D
-
S
Y
A
L
R
----
T
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
--
Y
P
Q
P
R
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
E
R
V
T
E
W
39
PsiBlast_CBE
85.12
35%
-99
- C6 -
3A06
3
DXR_THEMA
B:
[6-341]
L
V
I
L
G
A
T
G
S
I
G
T
Q
T
L
D
V
L
K
K
--
V
K-
G
-----
I
R
L
I
G
I
S
F
H
S
N
L
E
L
A
F
K
I
V
K
E
F
N
V
K
N
V
A
I
T
--
G
D
V
E
-
F
-
E
-
D
S
------
S
I
N
V
W
----
K
G
S
H
S
I
E
E
M
L
E
A
L
K
--
P
D
I
T
M
V
A
V
S
G
F
---
S
G
L
R
A
V
L
A
S
L
E
H
S
K
R
V
C
L
A
N
K
E
S
L
V
C
G
G
----
F
L
V
------
K
K
K
L
K
E
K
G
T
E
L
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
V
M
-
E
P
E
V
-----------
E
K
-----
V
-------------
V
L
T
A
S
G
G
A
L
R
D
-
W
K
I
S
K
I
D
R
A
R
P
E
D
V
L
K
H
P
V
W
N
M
G
A
R
I
T
V
D
S
A
T
M
V
N
K
A
F
E
V
L
E
A
M
E
L
F
E
L
P
F
E
K
-
I
E
V
K
I
H
R
E
G
L
V
H
G
A
V
V
L
P
D
G
N
V
K
M
V
V
S
P
P
D
M
R
I
P
I
S
Y
A
L
F
Y
-
P
R
R
V
A
L
----
E
P
F
F
L
R
T
I
S
-
L
S
F
E
D
P
D
P
E
K
Y
-
P
A
F
F
--
L
-
L
-
K
E
I
K
D
S
Y
A
-
L
R
----
T
A
F
N
A
A
D
E
V
A
V
E
A
F
L
K
G
R
I
R
F
G
G
I
H
R
V
I
E
K
T
L
E
E
F
Q
G
Y
P
Q
P
-
R
T
L
D
D
V
E
R
I
H
F
E
A
I
K
K
A
E
R
V
T
E
W
L
40
PsiBlast_CBE
85.04
33%
-84
- C6 -
3ANN
2
DXR_ECOLI
B:
[14-397]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
--
N
PE
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
LQQQGS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
MDAVKQ
S
K
------
A
Q
L
L
P
V
D
S
E
H
NAIFQSLPQPIQHN
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
41
PsiBlast_CBE
85.02
33%
-85
- C6 -
3ANM
2
DXR_ECOLI
B:
[14-397]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
--
N
PE
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
LQQQGS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
MDAVKQ
S
K
------
A
Q
L
L
P
V
D
S
E
H
NAIFQSLPQPIQHN
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
19
PsiBlast_PDB
84.82
33%
-85
- C6 -
2EGH
3
DXR_ECOLI
A:
[14-397]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
--
N
P
E
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
47
PsiBlast_CBE
84.71
33%
-86
- C6 -
1T1R
2
DXR_ECOLI
B:
[4-387]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
NP
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
LQQQGS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
MDAVKQ
S
K
------
A
Q
L
L
P
V
D
S
E
H
NAIFQSLPQPIQHN
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
46
PsiBlast_CBE
84.64
33%
-83
- C6 -
1T1S
3
DXR_ECOLI
A:
[4-387]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
17
PsiBlast_PDB
84.46
33%
-84
- C6 -
3ANM
2
DXR_ECOLI
A:
[14-397]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
--
N
PE
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
18
PsiBlast_PDB
84.27
33%
-84
- C6 -
3ANN
2
DXR_ECOLI
A:
[14-397]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
--
N
PE
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
48
PsiBlast_CBE
83.94
33%
-82
- C6 -
1T1R
2
DXR_ECOLI
A:
[4-387]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
45
PsiBlast_CBE
83.81
33%
-84
- C6 -
1T1S
2
DXR_ECOLI
B:
[4-387]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
NP
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
LQQQGS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
MDAVKQ
S
K
------
A
Q
L
L
P
V
D
S
E
H
NAIFQSLPQPIQHN
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
53
PsiBlast_CBE
83.20
33%
-81
- C6 -
1Q0Q
2
DXR_ECOLI
B:
[12-395]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
NP
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
LQQQGS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
MDAVKQ
S
K
------
A
Q
L
L
P
V
D
S
E
H
NAIFQSLPQPIQHN
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
54
PsiBlast_CBE
82.99
33%
-81
- C6 -
1Q0Q
2
DXR_ECOLI
A:
[12-395]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
44
PsiBlast_CBE
82.95
33%
-83
- C6 -
2EGH
3
DXR_ECOLI
B:
[14-397]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
--
N
PE
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
LQQQGS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
MDAVKQ
S
K
------
A
Q
L
L
P
V
D
S
E
H
NAIFQSLPQPIQHN
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
7
PsiBlast_PDB
82.84
36%
-89
- C6 -
3WQS
3
DXR_PLAFX
B:
[80-462]
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
--
C
--
N
KIENV
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
-
K
-
E
L
------
V
K
N
I
K
DYKP
I
I
L
C
G
D
E
G
M
K
E
I
C
S
--
S
N
S
I
D
K
I
V
I
G
I
DSF
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
FFLK
K
L
L
------
N
I
HKN---
A
K
I
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
C
L
D
N
N
K
V
-----------
L
K
-
T
-
K
C
L
QDNFSKINNINKI
F
L
C
S
S
G
G
P
F
Q
N
-
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
-
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
-
T
W
P
D
--
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
-
P
C
I
K
LA
Y
-
Q
-
A
G
I
K
G
N
F
--
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
5
PsiBlast_PDB
82.81
36%
-87
- C6 -
3WQQ
4
DXR_PLAFX
A:
[80-462]
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
--
C
--
N
K
I
ENV
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
-
K
-
E
L
------
V
K
N
I
K
DYKP
I
I
L
C
G
D
E
G
M
K
E
I
C
S
--
S
N
S
I
D
K
I
V
I
G
I
DSF
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
------
N
I
H
KN---
A
K
I
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
C
L
D
N
N
K
V
-----------
L
K
-
T
-
K
C
L
QDN
F
S
K
I
N
NINKI
F
L
C
S
S
G
G
P
F
Q
N
-
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
-
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
-
T
W
P
D
--
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
-
P
C
I
K
L
A
Y
-
Q
-
A
G
I
K
G
N
F
--
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
4
PsiBlast_PDB
82.75
36%
-87
- C6 -
3AUA
4
DXR_PLAFX
A:
[80-462]
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
--
C
--
N
K
I
ENV
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
-
K
-
E
L
------
V
K
N
I
K
DYKP
I
I
L
C
G
D
E
G
M
K
E
I
C
S
--
S
N
S
I
D
K
I
V
I
G
I
DSF
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
------
N
I
H
KN---
A
K
I
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
C
L
D
N
N
K
V
-----------
L
K
-
T
-
K
C
L
QDN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
-
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
-
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
-
T
W
P
D
--
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
-
P
C
I
K
L
A
Y
-
Q
-
A
G
I
K
G
N
F
--
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
50
PsiBlast_CBE
82.03
33%
-85
- C6 -
1ONP
2
DXR_ECOLI
A:
[4-387]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
-
M
E
A
F
E
Q
G
Q
A
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
30
PsiBlast_CBE
81.94
36%
-86
- C6 -
3AU9
5
DXR_PLAFX
B:
[80-462]
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
--
C
--
N
KIENV
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
-
K
-
E
L
------
V
K
N
I
K
DYKP
I
I
L
C
G
D
E
G
M
K
E
I
C
S
--
S
N
S
I
D
K
I
V
I
G
I
DSF
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
FFLK
K
L
L
------
N
I
HKN---
A
K
I
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
C
L
D
N
N
K
V
-----------
L
K
-
T
-
K
C
L
QDNFSKINNINKI
F
L
C
S
S
G
G
P
F
Q
N
-
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
-
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
-
T
W
P
D
--
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
-
P
C
I
K
LA
Y
-
Q
-
A
G
I
K
G
N
F
--
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
28
PsiBlast_CBE
81.86
36%
-85
- C6 -
3WQQ
5
DXR_PLAFX
B:
[80-462]
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
--
C
--
N
KIENV
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
-
K
-
E
L
------
V
K
N
I
K
DYKP
I
I
L
C
G
D
E
G
M
K
E
I
C
S
--
S
N
S
I
D
K
I
V
I
G
I
DSF
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
FFLK
K
L
L
------
N
I
HKN---
A
K
I
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
C
L
D
N
N
K
V
-----------
L
K
-
T
-
K
C
L
QDNFSKINNINKI
F
L
C
S
S
G
G
P
F
Q
N
-
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
-
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
-
T
W
P
D
--
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
-
P
C
I
K
LA
Y
-
Q
-
A
G
I
K
G
N
F
--
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
29
PsiBlast_CBE
81.51
36%
-87
- C6 -
3AUA
5
DXR_PLAFX
B:
[80-462]
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
--
C
--
N
KIENV
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
-
K
-
E
L
------
V
K
N
I
K
DYKP
I
I
L
C
G
D
E
G
M
K
E
I
C
S
--
S
N
S
I
D
K
I
V
I
G
I
DSF
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
FFLK
K
L
L
------
N
I
HKN---
A
K
I
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
C
L
D
N
N
K
V
-----------
L
K
-
T
-
K
C
L
QDNFSKINNINKI
F
L
C
S
S
G
G
P
F
Q
N
-
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
-
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
-
T
W
P
D
--
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
-
P
C
I
K
LA
Y
-
Q
-
A
G
I
K
G
N
F
--
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
6
PsiBlast_PDB
81.09
36%
-86
- C6 -
3WQR
4
DXR_PLAFX
A:
[80-462]
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
--
C
--
N
K
I
ENV
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
-
K
-
E
L
------
V
K
N
I
K
DYKP
I
I
L
C
G
D
E
G
M
K
E
I
C
S
--
S
N
S
I
D
K
I
V
I
G
I
DSF
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
------
N
I
H
KN---
A
K
I
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
C
L
D
N
N
K
V
-----------
L
K
-
T
-
K
C
L
QDN
F
S
K
I
N
NINKI
F
L
C
S
S
G
G
P
F
Q
N
-
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
-
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
-
T
W
P
D
--
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
-
P
C
I
K
L
A
Y
-
Q
-
A
G
I
K
G
N
F
--
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
55
PsiBlast_CBE
81.08
33%
-81
- C6 -
1Q0L
2
DXR_ECOLI
A:
[12-395]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
N
P
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
L
Q
Q
Q
GS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
M
D
A
V
K
Q
S
K
------
A
Q
L
L
P
V
D
S
E
H
N
A
I
F
Q
S
LP
Q
P
I
Q
H
N
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
M
E
A
F
E
Q
G
Q
A
-
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
3
PsiBlast_PDB
80.95
36%
-86
- C6 -
3AU9
4
DXR_PLAFX
A:
[80-462]
V
A
I
F
G
S
T
G
S
I
G
T
N
A
L
N
I
I
R
E
--
C
--
N
K
I
ENV
F
N
V
K
A
L
Y
V
N
K
S
V
N
E
L
Y
E
Q
A
R
E
F
L
P
E
Y
L
C
I
H
D
K
S
V
Y
E
E
L
-
K
-
E
L
------
V
K
N
I
K
DYKP
I
I
L
C
G
D
E
G
M
K
E
I
C
S
--
S
N
S
I
D
K
I
V
I
G
I
DSF
Q
G
L
Y
S
T
M
Y
A
I
M
N
N
K
I
V
A
L
A
N
K
E
S
I
V
S
A
G
F
F
L
K
K
L
L
------
N
I
H
KN---
A
K
I
I
P
V
D
S
E
H
--------------
S
A
I
F
Q
C
L
D
N
N
K
V
-----------
L
K
-
T
-
K
C
L
QDN
F
S
K
I
N
NIN
K
I
F
L
C
S
S
G
G
P
F
Q
N
-
L
T
M
D
E
L
K
N
V
T
S
E
N
A
L
K
H
P
K
W
K
M
G
K
K
I
T
I
D
S
A
T
M
M
N
K
G
L
E
V
I
E
T
H
F
L
F
D
V
D
Y
-
N
D
I
E
V
I
V
H
K
E
C
I
I
H
S
C
V
E
F
I
D
K
S
V
I
S
Q
M
Y
Y
P
D
M
Q
I
P
I
L
Y
S
L
-
T
W
P
D
--
R
I
K
T
N
L
K
P
L
D
L
A
Q
V
S
T
L
T
F
H
K
P
S
L
E
H
F
-
P
C
I
K
L
A
Y
-
Q
-
A
G
I
K
G
N
F
--
Y
P
----
T
V
L
N
A
S
N
E
I
A
N
N
L
F
L
N
N
K
I
K
Y
F
D
I
S
S
I
I
S
Q
V
L
E
S
F
N
S
Q
K
V
S
-
E
N
S
E
D
L
M
K
Q
I
L
Q
I
H
S
W
A
K
D
K
A
T
D
I
71
PsiBlast_CBE
80.52
34%
-91
- C6 -
2Y1D
2
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
------------------
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
----------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
49
PsiBlast_CBE
80.39
33%
-83
- C6 -
1ONP
2
DXR_ECOLI
B:
[4-387]
L
T
I
L
G
S
T
G
S
I
G
C
S
T
L
D
V
V
R
H
NP
E
--
H
-----
F
R
V
V
A
L
V
A
G
K
N
V
T
R
M
V
E
Q
C
L
E
F
S
P
R
Y
A
V
M
D
D
E
A
S
A
K
L
L
-
K
-
T
M
LQQQGS
R
T
E
V
L
----
S
G
Q
Q
A
A
C
D
M
A
A
L
E
D
--
V
D
Q
V
M
A
A
I
V
G
A
---
A
G
L
L
P
T
L
A
A
I
R
A
G
K
T
I
L
L
A
N
K
E
S
L
V
T
C
G
----
R
L
F
MDAVKQ
S
K
------
A
Q
L
L
P
V
D
S
E
H
NAIFQSLPQPIQHN
L
G
Y
A
D
L
E
-
Q
N
G
V
-----------
V
-----
S
I
-------------
L
L
T
G
S
G
G
P
F
R
E
-
T
P
L
R
D
L
A
T
M
T
P
D
Q
A
C
R
H
P
N
W
S
M
G
R
K
I
S
V
D
S
A
T
M
M
N
K
G
L
E
Y
I
E
A
R
W
L
F
N
A
S
A
S
Q
-
M
E
V
L
I
H
P
Q
S
V
I
H
S
M
V
R
Y
Q
D
G
S
V
L
A
Q
L
G
E
P
D
M
R
T
P
I
A
H
T
M
-
A
W
P
N
--
R
V
N
S
G
V
K
P
L
D
F
C
K
L
S
A
L
T
F
A
A
P
D
Y
D
R
Y
-
P
C
L
K
--
L
-
A
-
M
E
A
F
E
Q
G
Q
A
A
T
----
T
A
L
N
A
A
N
E
I
T
V
A
A
F
L
A
Q
Q
I
R
F
T
D
I
A
A
L
N
L
S
V
L
E
K
M
D
M
R
E
P
Q
---
C
V
D
D
V
L
S
V
D
A
N
A
R
E
V
A
R
K
E
V
M
R
82
PsiBlast_CBE
80.34
34%
-83
- C6 -
3ZHZ
1
DXR_MYCTU
A:
[23-389]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
---------------
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
-------
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
83
PsiBlast_CBE
79.54
34%
-84
- C6 -
3ZHY
3
DXR_MYCTU
B:
[23-389]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
58
PsiBlast_CBE
79.17
34%
-83
- C6 -
4AIC
3
DXR_MYCTU
B:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
LRAA--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
81
PsiBlast_CBE
79.15
34%
-88
- C6 -
3ZI0
1
DXR_MYCTU
A:
[23-389]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
-------------------
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A
--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
-
59
PsiBlast_CBE
78.44
34%
-78
- C6 -
4AIC
4
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
63
PsiBlast_CBE
78.41
34%
-79
- C6 -
3RAS
4
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A
--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
88
PsiBlast_CBE
78.07
34%
-82
- C6 -
4RCV
4
?
A:
[30-396]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
--------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
-
P
A
V
E
--
L
A
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
61
PsiBlast_CBE
77.67
34%
-81
- C6 -
4A03
4
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
62
PsiBlast_CBE
77.64
34%
-80
- C6 -
3RAS
5
DXR_MYCTU
B:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
LRAA--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
67
PsiBlast_CBE
77.62
34%
-80
- C6 -
2Y1F
4
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
------
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
78
PsiBlast_CBE
77.60
34%
-83
- C6 -
2JCV
2
DXR_MYCTU
B:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
LRAA--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
66
PsiBlast_CBE
77.60
34%
-80
- C6 -
2Y1F
3
DXR_MYCTU
B:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
60
PsiBlast_CBE
77.57
34%
-81
- C6 -
4A03
3
DXR_MYCTU
B:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
LRAA--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
79
PsiBlast_CBE
77.33
34%
-80
- C6 -
2JCV
3
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
77
PsiBlast_CBE
77.33
34%
-78
- C6 -
2JD1
4
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
94
PsiBlast_CBE
76.92
33%
-80
- C6 -
2JCX
3
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
N
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
90
PsiBlast_CBE
76.85
33%
-78
- C6 -
2JD0
3
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
N
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
W
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
Q
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
99
PsiBlast_CBE
76.47
33%
-77
- C6 -
4OOF
3
DXR_MYCTU
B:
[29-395]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
LRAA--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
F
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
-
P
A
V
E
--
L
A
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
84
PsiBlast_CBE
76.31
34%
-81
- C6 -
3ZHY
3
DXR_MYCTU
A:
[23-389]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
86
PsiBlast_CBE
76.19
34%
-79
- C6 -
3ZHX
2
DXR_MYCTU
A:
[23-389]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
-------
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
65
PsiBlast_CBE
76.15
34%
-78
- C6 -
2Y1G
4
DXR_MYCTU
A:
[24-390]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
-----
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
P
A
V
E
L
--
A
-
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G
100
PsiBlast_CBE
76.09
33%
-78
- C6 -
4OOF
3
DXR_MYCTU
A:
[29-395]
V
V
V
L
G
S
T
G
S
I
G
T
Q
A
L
Q
V
I
A
D
--
N
--
P
-----
D
R
F
E
V
V
G
L
A
A
G
G
A
H
L
D
T
L
L
R
Q
R
A
Q
T
G
V
T
N
I
A
V
A
D
E
H
A
A
-
Q
-
R
V
------
G
D
I
P
Y
----
H
G
S
D
A
A
T
R
L
V
E
Q
T
E
--
A
D
V
V
L
N
A
L
V
G
A
---
L
G
L
R
P
T
L
A
A
L
K
T
G
A
R
L
A
L
A
N
K
E
S
L
V
A
G
G
----
S
L
V
L
R
A
A--
R
P
------
G
Q
I
V
P
V
D
S
E
H
--------------
S
A
L
A
Q
C
L
-
R
G
G
T
-----------
P
D
-
E
V
A
K
L
-------------
V
L
T
A
S
G
G
P
F
R
G
W
S
A
A
D
L
E
H
V
T
P
E
Q
-
A
G
A
H
P
T
F
S
M
G
P
M
N
T
L
N
S
A
S
L
V
N
K
G
L
E
V
I
E
T
H
L
L
F
G
I
P
Y
D
R
-
I
D
V
V
V
H
P
Q
S
I
I
H
S
M
V
T
F
I
D
G
S
T
I
A
Q
A
S
P
P
D
M
K
L
P
I
S
L
A
L
-
G
W
P
R
R
V
S
G
A
A
A
A
--
C
D
F
H
T
A
S
S
W
E
F
E
P
L
D
T
D
V
F
-
P
A
V
E
--
L
A
R
-
Q
A
G
V
A
G
G
C
-
M
T
----
A
V
Y
N
A
A
N
E
E
A
A
A
A
F
L
A
G
R
I
G
F
P
A
I
V
G
I
I
A
D
V
L
H
A
A
D
Q
W
A
V
E
-
P
A
T
V
D
D
V
L
D
A
Q
R
W
A
R
E
R
A
Q
R
A
V
S
G