@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0232: (2015-12-13 )
MELNQPPLPTEIDDDAYHKPSFNDLGLKESVLKSVYEAGFTSPSPIQEKAIPAVLQGRDVIAQAQTGTGKTAAFALPIINNLKNNHTIKALVITPTRELAMQISDEIFKLGKHTRTKTVCVYGGQSVKKQCEFIKKNPQVMIATPGRLLDHLKNERIHKFVPKVVVLDESDEMLDMGFLDDIEEIFDYLPSEAQILLFSATMPEPIKRLADKILENPIKIHIAPSNITNTDITQRFYVINEHERAEAIMRLLDTQAPEKSIVFTRTKKEADELHQFLASKNYKSTALHGDMDQRDRRSSIMAFKKNDADVLVATDVASRGLDISGVSHVFSYHLPLNTESYIHRIGRTGRAGKKGMAITLVTPLEYKELLRMQKEIDSEIELFEIPTINENQIIKTLHDAKVSEGIISLYEQLTEIFEPSQLVLKLLSLQFETSKIGLNQQEIDAIQNPKEKTPKPPNKKTQHEPAHSFKKSHHRDRHPKTNRYSKKHKRR
Atome Classification :
(48 SA)
.........10........20-........30........40........50......--..60........70........80-.-----.-.--.-------------------...-----.------90-------------------........100.......110-..-.-....120-.......130.-..-..-..140......-----.150-...--....160.----.......170..-.--.-.-..180....--...----190.-..--......200.......210.......220.......230......--.--240-..--......250..-.....260.......270.......280.......290.......300.......310.......320.......330...------.------...340.......350.......360...-....370........380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELNQPPLPTEIDDDAYHKPS-FNDLG
L
K
E
S
V
L
K
S
V
Y
E
AGFTSPSP
I
Q
E
KA
I
P
A
V
LQG--
R
D
V
I
A
QAQTGTGK
T
A
A
F
A
L
P
I
I
N
N-L-----K-N--N-------------------
H
T
I
-----
K
------
A
L
-------------------
V
ITP
T
R
E
L
A
M
Q
I
S
D
E
I
F
K
LGK-HT-R-
T
K
T
V
C
V
Y-G
G
Q
S
V
K
K
Q
C
E
F
-
I
K-KN-P
Q
V
M
I
AT
P
G
R
L
-----
L
D
H
L
-
K
N
E
--
R
I
H
K
F-V
P
----
K
V
V
V
LDESD
E
M
L
-
D
--
M
-
G
-
F
L
D
D
I
E
E
I
F
--
D
YL----P--S-E
A
--
Q
I
L
L
F
SATM
P
E
P
I
K
R
L
A
D
K
I
LEN
P
I
K
I
H
IAPSNITNTD
I
T
Q
R
F
Y
V
--I--
N
-
E
-
H
E
--
R
A
E
A
I
M
R
L
L
DT-QAPEK
S
I
V
F
T
RTKK
E
A
D
E
L
H
Q
F
L
A
SKNYKSTALHGD
M
D
Q
R
D
R
R
S
S
I
M
A
FKKNDA
D
V
L
V
A
T
D
V
ASRGLDIS
G
V
S
H
V
F
S
YHLP------L------N
T
E
S
Y
I
H
R
IGRTGRAGKK
G
M
A
I
T
L
VT
P
L
E
-
Y
K
E
L
L
-
R
M
Q
K
E
IDSE
I
E
L
F
EIPTI
N
E
N
Q
I
I
K
T
L
H
D
A
K
V
S
E
G
I
I
S
L
Y
E
Q
L
T
E
IF
E
P
S
Q
L
V
L
K
L
L
S
L
Q
F
E
T
S
KIGL
N
Q
Q
E
I
D
A
IQNPKEKTPKPPNKKTQHE
P
A
H
S
F
K
K
SHHRDRHPKTN
R
Y
S
K
K
HKRR
30
PsiBlast_CBE
90.22
36%
-118
- C3 -
2VSX
1
IF4A_YEAST
B:
[24-388]
----------------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
-
I
-----
D
-
T
--
S
V------------------
K
A
P
-----
Q
------
A
L
-------------------
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
M
-
D
-
I
K
V
H
A
C
I
-
G
-----------
L
R
--
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
R
--
R
F
R
T
D
-
K
I
----
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
--
T
L
L
----
P
--
P
-
T
T
--
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
-
F
Y
V
--
N
--
V
-
E
-
E
E
EY
K
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
G
A
M
R
-
E
L
E
K
F
Y
S
T
Q
I
E
--
E
L
P
S
D
I
A
T
L
---------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
89.98
36%
-118
- C3 -
2VSX
1
IF4A_YEAST
A:
[24-388]
----------------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
-
I
-----
D
-
T
--
S
V------------------
K
A
P
-----
Q
------
A
L
-------------------
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
M
-
D
-
I
K
V
H
A
C
I
-
G
-----------
L
R
--
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
R
--
R
F
R
T
D
-
K
I
----
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
--
T
L
L
----
P
--
P
-
T
T
--
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
-
F
Y
V
--
N
--
V
-
E
-
E
E
EY
K
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
G
A
M
R
-
E
L
E
K
F
Y
S
T
Q
I
E
--
E
L
P
S
D
I
A
T
L
---------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
89.75
33%
-110
- C3 -
3EWS
1
DD19B_HUMAN
A:
[59-442]
----------------
Y
S
V
K
S
-
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
-----
E
P
A
--
N
-------------------
K
Y
P
-----
Q
------
C
L
-------------------
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
-
R
G
N
K
L
E
R
G
----
Q
K
-
I
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
-----
L
K
F
-
I
D
PKKI
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
M
L
----
P
--
R
-
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
E
T
-
L
D
T
I
K
Q
Y
Y
V
--
L
C
S
S
-
R
-
D
E
--
K
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
D
KDGNP
D
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
T
D
D
L
D
------------------------------------------------------------------------------------------------------
115
HHSearch
89.41
40%
-87
- C3 -
2DB3
3
VASA1_DROME
A:
[53-408]
----------------
Q
P
I
Q
H
-
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
-
L
-----
L
-
E
--
D
P
H
E
L
E
L
-------------
G
R
P
-----
Q
------
V
V
-------------------
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
-
Y
-
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
-
R
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
T
--
F
I
T
F
E
-
D
T
----
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
--
T
H
V
----
T
MR
P
-
E
H
--
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
--
V
--
N
-
K
-
Y
A
--
K
R
S
K
L
I
E
I
L
S
E
--
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
-
D
R
A
I
A
-
A
D
L
V
K
I
L
E
G
S
G
Q
T
V
P
D
F
L
R
------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
89.15
36%
-118
- C3 -
2VSO
1
IF4A_YEAST
B:
[24-388]
----------------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
-
I
-----
D
-
T
--
S
V------------------
K
A
P
-----
Q
------
A
L
-------------------
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
M
-
D
-
I
K
V
H
A
C
I
-
G
-----------
L
R
--
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
R
--
R
F
R
T
D
-
K
I
----
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
--
T
L
L
----
P
--
P
-
T
T
--
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
-
F
Y
V
--
N
--
V
-
E
-
E
E
EY
K
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
G
A
M
R
-
E
L
E
K
F
Y
S
T
Q
I
E
--
E
L
P
S
D
I
A
T
L
---------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
89.09
36%
-117
- C3 -
2VSO
1
IF4A_YEAST
A:
[24-388]
----------------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
-
I
-----
D
-
T
--
S
V------------------
K
A
P
-----
Q
------
A
L
-------------------
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
M
-
D
-
I
K
V
H
A
C
I
-
G
-----------
L
R
--
D
-
A
Q
I
V
V
G
T
P
G
R
V
-----
F
D
N
I
-
Q
R
R
--
R
F
R
T
D
-
K
I
----
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
-
F
K
E
Q
I
Y
Q
I
F
--
T
L
L
----
P
--
P
-
T
T
--
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
E
G
I
K
Q
-
F
Y
V
--
N
--
V
-
E
-
E
E
EY
K
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
G
A
M
R
-
E
L
E
K
F
Y
S
T
Q
I
E
--
E
L
P
S
D
I
A
T
L
---------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
88.97
40%
-94
- C3 -
2DB3
3
VASA1_DROME
C:
[58-406]
----------------------
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
-
L
L----
E
-
D
--
P
-------------------
H
E
L
ELGRP
Q
------
V
V
-------------------
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
-
Y
-
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
-
R
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
T
--
F
I
T
F
E
-
D
T
----
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
--
T
H
V
----
T
MR
P
-
E
H
--
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
--
V
--
N
-
K
-
Y
A
--
K
R
S
K
L
I
E
I
L
S
E
-
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
-
D
R
A
I
A
-
A
D
L
V
K
I
L
E
G
S
G
Q
T
V
P
D
F
L
R
------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
88.87
40%
-92
- C3 -
2DB3
3
VASA1_DROME
A:
[58-406]
----------------------
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
-
L
L
----
E
-
D
--
P
-------------------
H
E
L
E
L
GRP
Q
------
V
V
-------------------
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
-
Y
-
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
-
R
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
T
--
F
I
T
F
E
-
D
T
----
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
--
T
H
V
----
T
MR
P
-
E
H
--
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
--
V
--
N
-
K
-
Y
A
--
K
R
S
K
L
I
E
I
L
S
E
-
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
-
D
R
A
I
A
-
A
D
L
V
K
I
L
E
G
S
G
Q
T
V
P
D
F
L
R
------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
88.52
40%
-95
- C3 -
2DB3
3
VASA1_DROME
B:
[58-406]
----------------------
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
-
L
L----
E
-
D
--
P
-------------------
H
E
L
ELGRP
Q
------
V
V
-------------------
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
-
Y
-
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
-
R
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
T
--
F
I
T
F
E
-
D
T
----
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
--
T
H
V
----
T
MR
P
-
E
H
--
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
--
V
--
N
-
K
-
Y
A
--
K
R
S
K
L
I
E
I
L
S
E
-
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
-
D
R
A
I
A
-
A
D
L
V
K
I
L
E
G
S
G
Q
T
V
P
D
F
L
R
------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
88.44
40%
-93
- C3 -
2DB3
3
VASA1_DROME
D:
[58-406]
----------------------
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
-
L
L----
E
-
D
--
P
-------------------
H
E
L
ELGRP
Q
------
V
V
-------------------
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
-
Y
-
L
K
I
G
I
V
Y
-
G
G
T
S
F
R
H
Q
N
E
C
-
I
T
-
R
G
-
C
H
V
V
I
A
T
P
G
R
L
-----
L
D
F
V
-
D
R
T
--
F
I
T
F
E
-
D
T
----
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
S
E
D
M
R
R
I
M
--
T
H
V
----
T
MR
P
-
E
H
--
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
G
A
C
S
D
V
K
Q
T
I
Y
E
--
V
--
N
-
K
-
Y
A
--
K
R
S
K
L
I
E
I
L
S
E
-
Q
A
-
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
-
D
R
A
I
A
-
A
D
L
V
K
I
L
E
G
S
G
Q
T
V
P
D
F
L
R
------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
88.09
34%
-102
- C3 -
3RRN
3
DBP5_YEAST
A:
[6-389]
--------------------
S
-
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
-----
N
P
E
--
D
-------------------
A
S
P
-----
Q
------
A
I
-------------------
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
T
-
K
I
T
S
Q
L
I
V
P
-
D
S
F
E
K
N
K
Q
I
-------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
K
--
L
M
Q
L
Q
-
K
I
----
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
F
L
----
P
--
K
-
D
T
--
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-------
D
A
I
K
Q
L
Y
M
DC
K
--
N
-
E
-
A
D
--
K
F
D
V
L
T
E
L
Y
G
V
-
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
------
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
-
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
D
----------------------------------------------------------------------------------------
47
PsiBlast_CBE
87.69
33%
-103
- C3 -
3FHT
4
DD19B_HUMAN
A:
[22-399]
----------------
Y
S
V
K
S
-
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
-----
E
P
A
--
N
-------------------
K
Y
P
-----
Q
------
C
L
-------------------
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
-
R
G
N
K
L
E
R
G
----
Q
K
-
I
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
-----
L
K
F
-
I
D
PKKI
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
M
L
----
P
--
R
-
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
E
T
-
L
D
T
I
K
Q
Y
Y
V
--
L
C
S
S
-
R
-
D
E
--
K
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
DKDGNP
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
87.60
33%
-101
- C3 -
3FHT
6
DD19B_HUMAN
B:
[22-400]
----------------
Y
S
V
K
S
-
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
-----
E
P
A
--
N
-------------------
K
Y
P
-----
Q
------
C
L
-------------------
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
-
R
G
N
----------
K
-
I
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
-----
L
K
F
-
I
D
PKKI
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
M
L
----
P
--
R
-
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
E
T
-
L
D
T
I
K
Q
Y
Y
V
--
L
C
S
S
-
R
-
D
E
--
K
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
DKDGNP
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
-----------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
87.50
34%
-95
- C3 -
3PEW
10
DBP5_YEAST
A:
[6-389]
--------------------
S
-
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
-----
N
P
E
--
D
-------------------
A
S
P
-----
Q
------
A
I
-------------------
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
T
-
K
I
T
S
Q
L
I
V
P
-
D
S
F
E
K
N
K
Q
I
-------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
K
--
L
M
Q
L
Q
-
K
I
----
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
F
L
----
P
--
K
-
D
T
--
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-
T
N
E
V
N
V
D
A
I
K
Q
L
Y
M
DC
K
--
N
-
E
-
A
D
--
K
F
D
V
L
T
E
L
Y
G
V
-
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
------
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
-
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
-----------------------------------------------------------------------------------------
41
PsiBlast_CBE
87.44
34%
-95
- C3 -
3PEY
11
DBP5_YEAST
A:
[6-389]
--------------------
S
-
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
-----
N
P
E
--
D
-------------------
A
S
P
-----
Q
------
A
I
-------------------
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
T
-
K
I
T
S
Q
L
I
V
P
-
D
S
F
E
K
N
K
Q
I
-------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
K
--
L
M
Q
L
Q
-
K
I
----
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
F
L
----
P
--
K
-
D
T
--
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-
T
N
E
V
N
V
D
A
I
K
Q
L
Y
M
DC
K
--
N
-
E
-
A
D
--
K
F
D
V
L
T
E
L
Y
G
L
-
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
------
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
-
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
-----------------------------------------------------------------------------------------
121
HHSearch
87.25
42%
-102
- C3 -
1HV8
5
H669_METJA
A:
[5-364]
------------------
Y
M
N
-
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
E-
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
-
V
-----
N
-
E
--
N
-------------------
N
G
I
-----
E
------
A
I
-------------------
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
-
N
K
-
N
-
L
K
I
A
K
I
Y
-
G
G
K
A
I
Y
P
Q
I
K
--
A
L
-
K
N
-
A
N
I
V
V
G
T
P
G
R
I
-----
L
D
H
I
-
N
R
G
--
T
L
N
L
K
-
N
V
----
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
--
M
-
G
-
F
I
K
D
V
E
K
I
L
--
N
A
C
----
N
--
K
-
D
K
--
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
----
I
N
A
N
I
E
Q
S
Y
V
E
--
V
--
N
-
E
-
N
E
--
R
F
E
A
L
C
R
L
L
K
--
N
K
E
F
Y
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
------
Q
------
N
P
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
R
R
E
-
Y
K
K
L
R
-
Y
I
E
R
A
M
K
L
K
I
K
K
L
K
-----------------------------------------------------------------------------------------------------------
120
HHSearch
87.04
38%
-99
* C4 *
2I4I
1
DDX3X_HUMAN
A:
[10-391]
--------------
C
P
P
H
I
E
S
-
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
-----
Y
-
S
--
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
-----
I
------
S
L
-------------------
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
-
R
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
G
--
K
I
G
L
D
-
F
C
----
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
--
E
Q
D
TMPP
K
--
G
-
V
R
--
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
----
T
S
E
N
I
T
Q
K
V
V
W
--
V
--
E
-
E
-
S
D
--
K
R
S
F
L
L
D
L
L
N
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
N
I
T
K
-
D
L
L
D
L
L
V
E
A
K
Q
E
V
P
S
W
L
E
N
M
A
Y
E
H
H
Y
-----------------------------------------------------------------------------------------------
16
PsiBlast_PDB
86.94
38%
-106
- C3 -
3EIQ
-
IF4A1_HUMAN
A:
[33-399]
--------------------
S
-
F
D
D
M
N
L
S
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
L
P
C
I
K
G
--
Y
D
V
I
A
Q
A
Q
S
G
T
G
K
T
A
T
F
A
I
S
I
L
Q
Q
-
I
-----
E
-
L
--
D
L------------------
K
A
T
-----
Q
------
A
L
-------------------
V
L
A
P
T
R
E
L
A
Q
Q
I
Q
K
V
V
M
A
L
G
D
-
Y
M
-
G
-
A
S
C
H
A
C
I
-
G
G
T
N
V
R
A
E
V
Q
K
-
L
Q
M
E
A
-
P
H
I
I
V
G
T
P
G
R
V
-----
F
D
M
L
-
N
R
R
--
Y
L
S
P
K
-
Y
I
----
K
M
F
V
L
D
E
A
D
E
M
L
-
S
--
R
-
G
-
F
K
D
Q
I
Y
D
I
F
--
Q
K
L
----
N
--
S
-
N
T
--
Q
V
V
L
L
S
A
T
M
P
S
D
V
L
E
V
T
K
K
F
M
R
D
P
I
R
I
L
V
K
K
E
E
L
T
L
E
G
I
R
Q
-
F
Y
I
--
N
--
V
-
E
-
R
E
EW
K
L
D
T
L
C
D
L
Y
E
T
-
L
T
I
T
Q
A
V
I
F
I
N
T
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
F
T
V
S
A
M
---
M
D
Q
K
E
R
D
V
I
M
R
E
F
R
S
G
---
V
L
I
T
T
D
L
L
A
--
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
T
------
N
R
E
N
Y
I
H
R
I
G
R
G
-------
V
A
I
N
M
V
T
E
E
D
-
K
R
T
L
R
-
D
I
E
T
F
Y
N
T
S
I
E
--
E
M
P
L
--------------------------------------------------------------------------------------------------------
112
HHSearch
86.70
37%
-105
- C3 -
3EIQ
-
IF4A1_HUMAN
A:
[30-398]
-----------------
I
V
D
S
-
F
D
D
M
N
L
S
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
L
P
C
I
K
G
--
Y
D
V
I
A
Q
A
Q
S
G
T
G
K
T
A
T
F
A
I
S
I
L
Q
Q
-
I
-----
E
-
L
--
D
L------------------
K
A
T
-----
Q
------
A
L
-------------------
V
L
A
P
T
R
E
L
A
Q
Q
I
Q
K
V
V
M
A
L
G
D
-
Y
M
-
G
-
A
S
C
H
A
C
I
-
G
G
T
N
V
R
A
E
V
Q
K
L
Q
M
-
E
A
-
P
H
I
I
V
G
T
P
G
R
V
-----
F
D
M
L
-
N
R
R
--
Y
L
S
P
K
-
Y
I
----
K
M
F
V
L
D
E
A
D
E
M
L
-
S
--
R
-
G
-
F
K
D
Q
I
Y
D
I
F
--
Q
K
L
----
N
--
S
-
N
T
--
Q
V
V
L
L
S
A
T
M
P
S
D
V
L
E
V
T
K
K
F
M
R
D
P
I
R
I
L
V
K
K
E
E
L
T
L
E
G
I
R
Q
F
Y
I
N
--
V
--
E
R
E
-
E
W
--
K
L
D
T
L
C
D
L
Y
E
T
-
L
T
I
T
Q
A
V
I
F
I
N
T
R
R
K
V
D
W
L
T
E
K
M
H
A
R
D
F
T
V
S
A
M
---
M
D
Q
K
E
R
D
V
I
M
R
E
F
R
S
G
---
V
L
I
T
T
D
L
L
A
--
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
T
------
N
R
E
N
Y
I
H
R
I
G
R
G
-------
V
A
I
N
M
V
T
E
E
D
-
K
R
T
L
R
-
D
I
E
T
F
Y
N
T
S
I
E
E
M
P
L
----------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
86.65
33%
-99
- C3 -
3G0H
4
DD19B_HUMAN
A:
[38-416]
----------------
Y
S
V
K
S
-
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
-----
E
P
A
--
N
-------------------
K
Y
P
-----
Q
------
C
L
-------------------
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
-
R
G
N
K
L
E
R
G
----
Q
K
-
I
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
-----
L
K
F
-
I
D
PKKI
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
M
L
----
P
--
R
-
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
E
T
-
L
D
T
I
K
Q
Y
Y
V
--
L
C
S
S
-
R
-
D
E
--
K
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
DKDGNP
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
D
-----------------------------------------------------------------------------------------------------------
119
HHSearch
85.94
35%
-97
- C3 -
3FHT
4
DD19B_HUMAN
A:
[22-399]
----------------
Y
S
V
K
S
-
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
-----
E
-
P
--
A
N------------------
K
Y
P
-----
Q
------
C
L
-------------------
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
-
F
Y
-
P
E
L
K
L
A
Y
A
V
-
R
G
N
K
L
---
E
R
G
-
Q
K
-
I
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
L
K-
F
I
D
P
K
-
K
I
----
K
V
F
V
L
D
E
A
D
V
M
I
-
A
--
T
Q
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
M
L
----
P
--
R
-
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
E
T
L
D
T
I
K
Q
Y
Y
V
L
--
C
--
S
-
S
R
D
E
--
K
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
DKDGNP
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
M
N
I
L
N
-
R
I
Q
E
H
F
N
K
K
I
E
R
L
------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
84.85
34%
-104
- C3 -
3RRM
1
DBP5_YEAST
A:
[11-389]
--------------------------
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
-
V
-----
N
P
E
--
D
-------------------
A
S
P
-----
Q
------
A
I
-------------------
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
T
-
K
I
T
S
Q
L
I
V
P
-
D
S
F
E
K
N
K
Q
I
-------
N
-
A
Q
V
I
V
G
T
P
G
T
V
-----
L
D
L
M
-
R
R
K
--
L
M
Q
L
Q
-
K
I
----
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
-
L
G
D
Q
C
I
R
V
K
--
R
F
L
----
P
--
K
-
D
T
--
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
-----
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
--
N
-
E
-
A
D
--
K
F
D
V
L
T
E
L
Y
G
V
-
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
TLANGQ
A
------
D
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
F
N
I
L
-
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
D
----------------------------------------------------------------------------------------
50
PsiBlast_CBE
68.42
44%
-115
- C3 -
2GXS
3
?
A:
[3-205]
----------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
APSQ-
E
-
R
--
G
-------------------
R
K
P
-----
R
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
L
----
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
-
R
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
G
--
V
L
D
L
S
-
R
V
----
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
A
T
----
P
--
P
-
S
R
--
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
68.17
44%
-118
- C3 -
2GXQ
2
?
A:
[3-205]
----------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
APSQ-
E
-
R
--
G
-------------------
R
K
P
-----
R
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
L
----
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
-
R
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
G
--
V
L
D
L
S
-
R
V
----
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
A
T
----
P
--
P
-
S
R
--
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
68.07
43%
-114
- C3 -
3NBF
2
?
A:
[3-205]
----------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
APSQ-
E
-
R
--
G
-------------------
R
K
P
-----
R
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
L
----
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
-
R
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
G
--
V
L
D
L
S
-
R
V
----
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
A
T
----
P
--
P
-
S
R
--
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
67.80
43%
-122
- C3 -
3MWL
2
?
B:
[3-205]
----------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
APSQ-
E
-
R
--
G
-------------------
R
K
P
-----
R
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
L
----
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
-
R
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
G
--
V
L
D
L
S
-
R
V
----
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
A
T
----
P
--
P
-
S
R
--
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
67.62
44%
-113
- C3 -
2GXS
4
?
B:
[3-205]
----------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
APSQ-
E
-
R
--
G
-------------------
R
K
P
-----
R
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
L
----
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
-
R
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
G
--
V
L
D
L
S
-
R
V
----
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
A
T
----
P
--
P
-
S
R
--
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
67.50
43%
-120
- C3 -
3NBF
2
?
D:
[3-205]
----------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
APSQ-
E
-
R
--
G
-------------------
R
K
P
-----
R
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
L
----
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
-
R
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
G
--
V
L
D
L
S
-
R
V
----
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
A
T
----
P
--
P
-
S
R
--
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
66.81
43%
-114
- C3 -
3NBF
2
?
B:
[3-205]
----------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
A
P
S
Q-
E
-
R
--
G
-------------------
R
K
P
-----
R
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
L
----
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
-
R
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
G
--
V
L
D
L
S
-
R
V
----
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
A
T
----
P
--
P
-
S
R
--
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
66.69
43%
-115
- C3 -
3NBF
4
?
C:
[3-205]
----------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
APSQ-
E
-
R
--
G
-------------------
R
K
P
-----
R
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
L
----
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
-
R
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
G
--
V
L
D
L
S
-
R
V
----
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
A
T
----
P
--
P
-
S
R
--
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
66.45
43%
-117
- C3 -
3MWK
2
?
B:
[3-205]
----------------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
-
L
APSQ-
E
-
R
--
G
-------------------
R
K
P
-----
R
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
L
----
K
V
V
A
V
Y
-
G
G
T
G
Y
G
K
Q
K
E
A
-
L
L
-
R
G
-
A
D
A
V
V
A
T
P
G
R
A
-----
L
D
Y
L
-
R
Q
G
--
V
L
D
L
S
-
R
V
----
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
-
F
E
E
E
V
E
A
L
L
--
S
A
T
----
P
--
P
-
S
R
--
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
65.69
34%
-116
- C3 -
3FE2
4
DDX5_HUMAN
B:
[30-238]
--------------------
N
-
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
-
I
-----
N
-
H
--
Q
-------------------
P
F
L
-----
E
RGDGPI
C
L
-------------------
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
-
A
C
-
R
-
L
K
S
T
C
I
Y
-
G
G
A
P
K
G
P
Q
I
R
D
-
L
E
-
R
G
-
V
E
I
C
I
A
T
P
G
R
L
-----
I
D
F
L
-
E
C
G
--
K
T
N
L
R
-
R
T
----
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
K
I
V
--
D
Q
I
----
R
--
P
-
D
R
--
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
I
G
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
65.18
34%
-116
- C3 -
3FE2
3
DDX5_HUMAN
A:
[30-238]
--------------------
N
-
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
-
I
-----
N
-
H
--
Q
-------------------
P
F
L
-----
E
RGDGPI
C
L
-------------------
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
-
A
C
-
R
-
L
K
S
T
C
I
Y
-
G
G
A
P
K
G
P
Q
I
R
D
-
L
E
-
R
G
-
V
E
I
C
I
A
T
P
G
R
L
-----
I
D
F
L
-
E
C
G
--
K
T
N
L
R
-
R
T
----
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
K
I
V
--
D
Q
I
----
R
--
P
-
D
R
--
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
N
I
G
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
63.93
36%
-109
- C3 -
1T6N
1
DX39B_HUMAN
B:
[14-220]
-------------------
S
G
-
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
-
L
-----
E
P
V
--
T
-------------------
G
Q
V
-----
S
------
V
L
-------------------
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
-
Y
M
P
N
-
V
K
V
A
V
F
F
-
G
G
L
S
I
K
K
D
E
E
V
-
L
K
-
K
N
C
P
H
I
V
V
G
T
P
G
R
I
-----
L
A
L
A
-
R
N
K
--
S
L
N
L
K
-
H
I
----
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
-
M
R
R
D
V
Q
E
I
F
--
R
M
T
----
P
--
H
-
E
K
--
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
63.52
37%
-110
- C3 -
3FMO
1
DD19B_HUMAN
B:
[89-292]
----------------
Y
S
V
K
S
-
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
-
V
-----
E
P
A
--
N
-------------------
K
Y
P
-----
Q
------
C
L
-------------------
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
K
L
A
Y
A
V
-
R
G
N
K
L
E
R
G
----
Q
K
-
I
S
-
E
Q
I
V
I
G
T
P
G
T
V
-----
L
D
W
C
-
S
K
-----
L
K
F
-
I
D
PKKI
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
-
H
Q
D
Q
S
I
R
I
Q
--
R
M
L
----
P
--
R
-
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
62.68
40%
-107
- C3 -
3BER
4
DDX47_HUMAN
A:
[44-248]
--------------------
T
-
F
K
D
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
G
--
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
A
L
L
-----
E
-
T
--
P
-------------------
Q
R
L
-----
F
------
A
L
-------------------
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
S
-
S
I
-
G
-
V
Q
S
A
V
I
V
-
G
G
I
D
S
M
S
Q
S
L
A
-
L
A
-
K
K
-
P
H
I
I
I
A
T
P
G
R
L
-----
I
D
H
L
-
E
N
T
--
K
G
F
N
L
R
A
L
----
K
Y
L
V
M
D
E
A
D
R
I
L
-
N
--
M
-
D
-
F
E
T
E
V
D
K
I
L
--
K
V
I
----
P
--
R
-
D
R
--
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
V
K
C
A
V
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
62.65
35%
-102
- C3 -
4PX9
1
DDX3X_HUMAN
A:
[63-291]
-----------------
H
I
E
S
-
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
-----
Y
-
S
--
D
-------------------
G
P
G
-----
E
------
A
L
RAMKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
-
R
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
G
--
K
I
G
L
D
-
F
C
----
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
EQ
D
T
M
----
P
--
P
-
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
62.35
36%
-107
- C3 -
3IUY
2
DDX53_HUMAN
B:
[15-228]
------
P
K
P
T
C
R
F
K
D
A
F
Q
Q
---
Y
P
D
L
------
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
-
L
-----
D
-
S
-------------------------------NGPG--
M
L
-------------------
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
C
S
K
Y
-
S
-
Y
K
-
G
-
L
K
S
I
C
I
Y
-
G
-----------------
V
D
I
I
I
A
T
P
G
R
L
-----
N
D
L
Q
-
M
N
N
--
S
V
N
L
R
-
S
I
----
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
--
M
-
E
-
F
E
P
Q
I
R
K
I
L
--
L
D
V
----
R
--
P
-
D
R
--
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
I
V
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
62.33
36%
-106
- C3 -
1T6N
1
DX39B_HUMAN
A:
[14-220]
-------------------
S
G
-
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
-
L
-----
E
P
V
--
T
-------------------
G
Q
V
-----
S
------
V
L
-------------------
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
-
Y
M
P
N
-
V
K
V
A
V
F
F
-
G
G
L
S
I
K
K
D
E
E
V
-
L
K
-
K
N
C
P
H
I
V
V
G
T
P
G
R
I
-----
L
A
L
A
-
R
N
K
--
S
L
N
L
K
-
H
I
----
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
-
M
R
R
D
V
Q
E
I
F
--
R
M
T
----
P
--
H
-
E
K
--
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
62.27
35%
-100
- C3 -
4PX9
1
DDX3X_HUMAN
B:
[63-291]
-----------------
H
I
E
S
-
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
-----
Y
-
S
--
D
-------------------
G
P
G
-----
E
------
A
L
RAMKENGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
-
R
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
G
--
K
I
G
L
D
-
F
C
----
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
EQ
D
T
M
----
P
--
P
-
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
62.12
36%
-110
- C3 -
3IUY
2
DDX53_HUMAN
A:
[15-228]
------
P
K
P
T
C
R
F
K
D
A
F
Q
Q
---
Y
P
D
L
------
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
-
L
-----
D
---------------------------------NGPG--
M
L
-------------------
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
C
S
K
Y
-
S
-
Y
K
-
G
-
L
K
S
I
C
I
Y
-
G
------
Q
I
E
D
-
I
S
-
K
G
-
V
D
I
I
I
A
T
P
G
R
L
-----
N
D
L
Q
-
M
N
N
--
S
V
N
L
R
-
S
I
----
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
--
M
-
E
-
F
E
P
Q
I
R
K
I
L
--
L
D
V
----
R
--
P
-
D
R
--
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
I
V
Y
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
61.92
38%
-115
- C3 -
2PL3
5
DDX10_HUMAN
A:
[27-227]
----------------------
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
-
L
Y
R
L
QW
T
-
S
--
T
-------------------
D
G
L
-----
G
------
V
L
-------------------
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
K
-
N
H
-
D
-
F
S
A
G
L
I
I
-
G
G
--
L
K
H
E
A
E
R
-
I
N
--
N
-
I
N
I
L
V
C
T
P
G
R
L
-----
L
Q
H
M
D
E
T
V
--
S
F
H
A
T
-
D
L
----
Q
M
L
V
L
D
E
A
D
R
I
L
-
D
--
M
-
G
-
F
A
D
T
M
N
A
V
I
--
E
N
L
----
P
--
K
-
K
R
--
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
W
V
H
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
61.68
33%
-114
- C3 -
3B7G
1
DDX20_HUMAN
B:
[24-228]
--------------------
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
-
L
-----
V
L
E
--
N
-------------------
L
S
T
-----
Q
------
I
L
-------------------
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
-
K
M
-
E
-
G
L
E
C
H
V
F
-
I
G
G
T
P
L
S
Q
D
K
T
-
R
L
-
K
K
-
C
H
I
A
V
G
S
P
G
R
I
KQLIE
L
D
Y
L
-
N
P
G
--
S
I
R
L
F
----------
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
--
S
S
L
----
P
--
A
-
S
K
--
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
61.30
33%
-111
- C3 -
3B7G
1
DDX20_HUMAN
A:
[24-228]
--------------------
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
-
L
-----
V
L
E
--
N
-------------------
L
S
T
-----
Q
------
I
L
-------------------
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
-
K
M
-
E
-
G
L
E
C
H
V
F
-
I
G
G
T
P
L
S
Q
D
K
T
-
R
L
-
K
K
-
C
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
D
Y
L
-
N
P
G
--
S
I
R
L
F
----------
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
--
S
S
L
----
P
--
A
-
S
K
--
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
61.20
35%
-101
- C3 -
4PX9
1
DDX3X_HUMAN
C:
[63-291]
-----------------
H
I
E
S
-
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
-
I
-----
Y
-
S
--
D
-------------------
G
P
G
-----
E
------
A
L
RAMKENGRYGRRKQYPISL
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
R
P
C
V
V
Y
-
G
G
A
D
I
G
Q
Q
I
R
D
-
L
E
-
R
G
-
C
H
L
L
V
A
T
P
G
R
L
-----
V
D
M
M
-
E
R
G
--
K
I
G
L
D
-
F
C
----
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
-
F
E
P
Q
I
R
R
I
V
EQ
D
T
M
----
P
--
P
-
K
G
VR
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
60.85
33%
-111
- C3 -
2OXC
1
DDX20_HUMAN
A:
[24-228]
--------------------
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
-
L
-----
V
L
E
--
N
-------------------
L
S
T
-----
Q
------
I
L
-------------------
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
-
K
M
-
E
-
G
L
E
C
H
V
F
-
I
G
G
T
P
L
S
Q
D
K
T
-
R
L
-
K
K
-
C
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
D
Y
L
-
N
P
G
--
S
I
R
L
F
----------
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
--
S
S
L
----
P
--
A
-
S
K
--
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
60.63
33%
-113
- C3 -
2OXC
1
DDX20_HUMAN
B:
[24-228]
--------------------
A
D
F
E
S
L
L
L
S
R
P
V
L
E
G
L
R
A
A
G
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
-
L
-----
V
L
E
--
N
-------------------
L
S
T
-----
Q
------
I
L
-------------------
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
-
K
M
-
E
-
G
L
E
C
H
V
F
-
I
G
G
T
P
L
S
Q
D
K
T
-
R
L
-
K
K
-
C
H
I
A
V
G
S
P
G
R
I
KQLIE
L
D
Y
L
-
N
P
G
--
S
I
R
L
F
----------
I
L
D
E
A
D
K
L
L
-
E
--
E
-
G
S
F
Q
E
Q
I
N
W
I
Y
--
S
S
L
----
P
--
A
-
S
K
--
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
T
F
V
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
56.42
35%
-102
- C3 -
3DKP
4
DDX52_HUMAN
A:
[40-242]
-------------------------------
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
V
M
L
H
G
--
R
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
I
L
M
Q
-
L
-----
K
-
Q
PA
N
-------------------
K
G
F
-----
R
------
A
L
-------------------
I
I
S
P
T
R
E
L
A
S
Q
I
H
R
E
L
I
K
I
S
E
-
G
T
-
G
-
F
R
I
H
M
I
H
K
A
A
V
A
A
K
K
F
G
P
K
-
S
S
-
K
K
-
F
D
I
L
V
T
T
P
N
R
L
-----
I
Y
L
L
-
K
Q
D
PP
G
I
D
L
A
-
S
V
----
E
W
L
V
V
D
E
S
D
K
L
F
-
E
D
G--
G
-
F
R
D
Q
L
A
S
I
F
--
L
A
C
----
T
--
S
H
K
V
--
R
R
A
M
F
S
A
T
F
A
Y
D
V
E
Q
W
C
K
L
N
L
D
N
V
I
S
V
S
I
G
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------