@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0266: (2015-12-14 )
MDFQLQAVDDNARAGVLNLAHSQVETPVFMPVGTQGCIKSLDAMDAQEILGAKLILANTYHMYLRPGEKVVEQLGGLHRFAQFQGSFLTDSGGFQAFSLSDNVKLQEDGIVFKSHIDGSKHLFTPIKVLDIQYSLNSDIMMVLDDLVGLPAPLKRLEESIKRSAKWANMSLEYHKENNRPNNNLFAIIQGGTHLKMRSLSVGLTHEGFDGYAIGGLAVGESVDEMLETIAHTAPLLPKDKPRYLMGVGTPENILDAISLGVDMFDCVMPTRNARNATLFTHSGKISIKNAPYKLDDTPIEENCACYACKRYSKAYLHHLFRAKELTYARLASLHNLHFYLELVKNARNAILEKRFLSFKKEFLEKYHSCSH
Atome Classification :
(43 SA)
---.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.--......180.--......190.......200.....-...210.......220--........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---M
D
F
Q
L
Q
AVDDNARA
G
V
L
N
LAHSQVET
P
V
F
M
PVG
T
Q
G
C
I
K
S
L
D
A
M
D
A
Q
E
I
LG
A
K
L
I
L
AN
T
Y
H
M
Y
LR
P
G
E
K
V
V
E
Q
L
G
G
L
H
R
F
A
Q
FQG
S
F
LTDSGG
F
Q
A
F
SLSDN
V
K
LQED
G
I
V
F
K
SHIDGSKHL
F
T
P
I
K
V
L
D
I
Q
Y
SLNS
D
I
M
M
V
L
D
D
L
VGL
P
A
P
L
K
R
L
E
E
S
I
K
RSAKWAN
M
S
L
E
Y
--HKENNRPNN
N
--
L
F
A
I
IQGG
T
H
L
K
M
R
S
L
S
V-GLTHE-GFDG
Y
A
IG
G
L
AV
G
E
S
---
V
D
E
M
L
E
T
I
A
HTAPLLPKDKP
R
Y
L
M
GVG
T
P
E
N
I
L
D
A
I
S
L
G
V
D
M
F
D
C
VMPTRNAR
N
A
T
L
F
THS
G
K
I
S
IKNAPYKLDDTPIEENC
A
C
Y
A
C
K
R
Y
S
K
A
Y
L
H
H
L
F
R
A
K
E
L
T
Y
A
R
L
A
S
L
H
N
L
H
F
Y
L
E
L
V
K
N
A
R
N
A
I
L
E
K
R
F
L
S
F
K
K
E
F
L
E
K
Y
HSCSH
39
PsiBlast_CBE
97.17
43%
-94
- C4 -
3SM0
4
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
19
PsiBlast_PDB
96.78
43%
-89
- C4 -
1S38
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
14
PsiBlast_PDB
96.54
43%
-88
- C4 -
1P0B
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
58
PsiBlast_CBE
96.45
43%
-88
- C4 -
4LEQ
5
TGT_ZYMMO
A:
[18-383]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
-
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
78
PsiBlast_CBE
96.35
43%
-89
- C4 -
4HSH
9
TGT_ZYMMO
A:
[15-380]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
----
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
57
PsiBlast_CBE
96.32
43%
-88
- C4 -
4Q8V
3
TGT_ZYMMO
A:
[18-383]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
75
PsiBlast_CBE
96.31
43%
-87
- C4 -
1EFZ
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
A
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
87
PsiBlast_CBE
96.30
43%
-89
- C4 -
4DXX
5
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
--
T
V
M
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
27
PsiBlast_CBE
96.22
43%
-90
- C4 -
4Q4O
6
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
47
PsiBlast_CBE
96.21
43%
-87
- C4 -
2QII
5
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
20
PsiBlast_PDB
96.15
43%
-91
- C4 -
2BBF
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
67
PsiBlast_CBE
96.11
43%
-89
- C4 -
4HQV
6
TGT_ZYMMO
A:
[15-380]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
1
PsiBlast_PDB
96.08
43%
-91
- C4 -
4GD0
6
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
82
PsiBlast_CBE
96.05
43%
-90
- C4 -
4Q8M
9
TGT_ZYMMO
A:
[18-383]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
59
PsiBlast_CBE
96.05
43%
-90
- C4 -
4LBU
6
TGT_ZYMMO
A:
[18-383]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
17
PsiBlast_PDB
96.05
43%
-87
- C4 -
1Q65
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
91
PsiBlast_CBE
95.99
43%
-89
* C4 *
4Q8P
5
TGT_ZYMMO
A:
[18-383]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
D
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
--
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
5
PsiBlast_PDB
95.96
43%
-87
- C4 -
1OZM
1
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
35
PsiBlast_CBE
95.90
43%
-92
- C4 -
4GH3
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
-----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
18
PsiBlast_PDB
95.88
43%
-93
- C4 -
1Q66
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
---
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
46
PsiBlast_CBE
95.83
43%
-87
- C4 -
3C2Y
7
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
36
PsiBlast_CBE
95.63
43%
-92
- C4 -
4GH1
3
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
------
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
88
PsiBlast_CBE
95.58
43%
-88
- C4 -
4IPP
6
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
D
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
81
PsiBlast_CBE
95.48
43%
-91
- C4 -
4Q8O
6
TGT_ZYMMO
A:
[18-383]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
32
PsiBlast_CBE
95.27
43%
-92
- C4 -
4GKT
3
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
41
PsiBlast_CBE
95.24
43%
-91
- C4 -
3GE7
4
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
42
PsiBlast_CBE
95.08
43%
-89
- C4 -
3GC5
5
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
31
PsiBlast_CBE
94.88
43%
-91
- C4 -
4PUJ
7
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
--
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
85
PsiBlast_CBE
94.87
43%
-90
- C4 -
4PUL
3
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
N
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
86
PsiBlast_CBE
94.82
43%
-89
- C4 -
4PUM
4
TGT_ZYMMO
A:
[18-383]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
N
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
45
PsiBlast_CBE
94.77
43%
-96
- C4 -
3EOS
4
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
-----
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
124
Fugue
94.70
43%
-91
- C4 -
1K4G
2
TGT_ZYMMO
A:
[11-382]
RPR
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
-
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
--
F
D
S
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
-
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
---GEG
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
83
PsiBlast_CBE
94.54
43%
-92
- C4 -
2NQZ
8
TGT_ZYMMO
A:
[15-380]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-------
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
S
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
43
PsiBlast_CBE
94.43
43%
-88
- C4 -
3GC4
7
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
----------
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
38
PsiBlast_CBE
94.39
43%
-94
- C4 -
4FR1
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
------------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
-
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
34
PsiBlast_CBE
94.10
43%
-91
- C4 -
4GI4
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
44
PsiBlast_CBE
93.77
43%
-93
- C4 -
3EOU
4
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
48
PsiBlast_CBE
93.74
43%
-88
- C4 -
2PWU
5
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
---
K
Q
S
E
E
G
V
T
F
K
S
-------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
-----
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
40
PsiBlast_CBE
93.67
43%
-89
- C4 -
3RR4
4
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
84
PsiBlast_CBE
93.17
43%
-92
- C4 -
1PXG
10
TGT_ZYMMO
A:
[15-380]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
E
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
37
PsiBlast_CBE
93.15
43%
-97
- C4 -
4FR6
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
-----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
----
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----
92
PsiBlast_CBE
92.89
43%
-96
- C4 -
4L56
8
TGT_ZYMMO
A:
[18-383]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
-
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
D
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---
33
PsiBlast_CBE
91.68
43%
-94
- C4 -
4GIY
2
TGT_ZYMMO
A:
[16-381]
-----
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
-----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
A
E
N
A
A
--
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
-
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----