@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0323: (2015-12-14 )
MDRAKFIFVTGGVLSSLGKGISSSSIATLLQHCNYQVSILKIDPYINIDPGTMSPLEHGEVFVTSDGAETDLDIGHYERFLNRNLTRLNNFTTGQIFSSVIENERKGEYLGKTIQIVPHVTDEIKRRIKSAAKGLDFLIVEVGGTVGDMEGMFYLEAIRQLKLELGNEKVINVHVTLIPYIQTTNELKTKPTQHSVQELRRLGVTPQIILARSPKPLDKELKKKIALSCDVEQDSVIVATDTKSIYACPILFLQEGILTPIARRFNLNKLHPKMAAWNTLVEKIIAPKHKVKIGFVGKYLSLKESYKSLIEALIHAGAHLDTQVNIEWLDSENFNEKTDLEGVDAILVPGGFGERGIEGKICAIQRARLEKLPFLGICLGMQLAIVEFCRNVLGLKGANSTEFNQRCEYPVVYLIEDFMDQNHQKQVRTYNSPLGGTMRLGEYECEIMPNSLLEKAYKKPNIKERHRHRYEINPKYRQEWENKGLKVVGFGANHLIEAIELEDHPFFVGVQFHPEFTSRLQSPNPIILDFIKSALHKS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130--.--.------..-------...140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..--.--....290.......300.......310.......320.......330....-------------.--..-----340-------------.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440...-..-..450.......-460.......470.......480.......-490..-.-.....500-........510.......520.......530......----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDR
A
K
F
I
F
VT
G
G
V
L
S
S
L
GKGIS
S
S
S
I
A
T
L
L
Q
HCN
Y
Q
V
S
I
L
K
ID
P
Y
I
N
IDPGTMSPLEHG
E
V
F
V
TSDGAETDL
D
I
G
H
Y
E
R
F
L
N
R
N
L
T
R
LNNF
T
T
G
Q
I
F
S
S
V
I
ENERKGEYLG
K
T
I
Q
IVPH
V
T
D
E
I
K
R
R
I
K
S
A
A--K--G------L
D
-------
F
L
I
V
EVGGTVGDM
E
G
M
F
Y
L
E
A
I
R
Q
L
K
L
E
LGN
E
K
V
I
N
V
H
V
T
L
I
P
Y
IQTTNELKTKP
T
Q
H
S
V
Q
E
L
R
RLGVT
P
Q
I
I
L
ARSPK
P
L
D
K
E
L
K
K
KI
A
L
S
C
DVEQD
S
V
I
V
A
TDTK
S
I
Y
A
C
P
I
L
F
L
QEG
I
L
T
P
I
A
R
RFNLNKLH
P
K
M
A
A
W
N
T
L
V
E
K
I
--I--APK
H
K
V
K
I
G
F
V
G
K
Y
L
S
L
K
E
S
Y
K
S
L
I
E
A
L
I
HAGAHL
D
T
Q
V
N
I
E
WLDSENFNE-------------K--TD-----LEG-------------V
D
A
I
L
VPGGFGERGIEG
K
I
C
A
I
Q
R
A
R
L
EKLP
F
L
G
I
C
L
G
M
Q
L
A
I
V
E
F
C
R
N
V
LGLKGANSTEFNQRCEY
P
V
V
Y
L
I
E
D
F
MDQ
N
H
Q
K
Q
V
R
TYNSPLGG
T
M
R
LG
E
Y
E
C
-EI-M
P
N
S
L
L
E
K
A
YKK-P
N
I
K
E
R
H
RHRYEI
N
P
K
Y
R
Q
E
W
ENKG
L
K
V
V
G-F-GA
N
-
H
-
L
I
E
A
I
EL--EDH
P
F
F
V
G
V
Q
F
H
P
E
F
T
S
RLQSPNP
I
I
L
D
F
I
K
S
A
LHKS----
19
PsiBlast_CBE
97.50
49%
-98
- C2 -
2AD5
5
PYRG_ECOLI
B:
[5-536]
-----
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
G
--
E
--
G
------
H
D
-------
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
V
E
T
-------------
R
GV
E
I
-----
L
K
G
-------------
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
E
N
G
N
V
E
V
---------
T
M
R
L
G
A
Q
Q
C
-
Q
L
-
V
D
D
S
L
V
R
Q
L
Y
N
A
-
P
T
I
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
-
G
D
D
-
Q
-
L
V
E
I
I
E
V
--
P
N
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
----
62
Fugue
96.56
48%
-93
- C2 -
1S1M
14
PYRG_ECOLI
A:
[1-544]
M
T
-
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
G
--
E
--
G
------
H
D
-------
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
V
E
T
-------------
R
GV
E
I
-----
L
K
G
-------------
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
E
N
----------
G
N
V
E
T
M
R
L
G
A
Q
Q
C
-
Q
L
-
V
D
D
S
L
V
R
Q
L
Y
N
A
-
P
T
I
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
-
R
S
G
D
D
-
Q
-
L
V
E
I
I
E
V
--
P
N
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
Q
A
20
PsiBlast_CBE
96.51
49%
-97
- C2 -
1S1M
16
PYRG_ECOLI
B:
[5-536]
-----
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
G
--
E
--
G
------
H
D
-------
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
D
V
E
T
-------------
R
GV
E
I
-----
L
K
G
-------------
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
E
N
G
N
V
E
V
---------
T
M
R
L
G
A
Q
Q
C
-
Q
L
-
V
D
D
S
L
V
R
Q
L
Y
N
A
-
P
T
I
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
-
G
D
D
-
Q
-
L
V
E
I
I
E
V
--
P
N
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
----
24
PsiBlast_CBE
96.21
46%
-102
- C2 -
4ZDI
1
PYRG_MYCTU
F:
[11-547]
----
K
H
L
F
V
S
G
-----
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
AAAA-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
31
HHSearch
96.16
48%
-94
- C2 -
3NVA
-
PYRG_SULSO
A:
[2-534]
--
P
N
K
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
V
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
R
Y
A
S
K
I
N
--
N
------
A
E
-------
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
I
A
L
V
E
Y
L
S
V
T
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
D
R
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
--
K
GI
N
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
K
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
T
D
L
E
S
DTKNL--------
N
--
E
I
-----
L
G
N
-------------
V
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
N
P
N
T
K
D
P
V
I
T
L
L
D
E
Q
----------
K
N
V
T
Q
L
G
G
T
M
R
L
G
A
Q
K
I
-
I
L
-
K
E
G
T
I
A
Y
Q
L
Y
G
K
-
K
V
V
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
E
D
A
G
L
V
V
S
G
-
I
-
S
E
N
-
G
-
L
V
E
I
I
E
L
--
P
S
N
K
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
------
23
PsiBlast_CBE
95.78
46%
-99
- C2 -
4ZDI
1
PYRG_MYCTU
G:
[11-547]
----
K
H
L
F
V
S
G
---
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
AAAA-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
1
PsiBlast_PDB
95.73
48%
-95
- C2 -
3NVA
-
PYRG_SULSO
A:
[4-532]
----
K
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
V
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
R
Y
A
S
--
K
I
N
N
------
A
E
-------
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
I
A
L
V
E
Y
L
S
V
T
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
D
R
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
K
G
I
--
N
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
K
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
T
D
L
E
S
-------------
D
--
T
K
NLNEI
L
G
N
-------------
V
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
N
P
N
T
K
D
P
V
I
T
L
L
D
E
------
Q
K
N
V
----
T
Q
L
G
G
T
M
R
L
G
A
Q
K
I
-
I
L
-
K
E
G
T
I
A
Y
Q
L
Y
G
K
-
K
V
V
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
E
D
A
G
L
V
V
S
G
-
I
-
S
E
N
-
G
-
L
V
E
I
I
E
L
--
P
S
N
K
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
------
28
PsiBlast_CBE
95.71
46%
-100
- C2 -
4ZDI
1
PYRG_MYCTU
B:
[11-547]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
A
A
A
A
-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
-------------------
G
G
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
P
P
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
25
PsiBlast_CBE
95.69
46%
-100
- C2 -
4ZDI
1
PYRG_MYCTU
E:
[11-547]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
AAAA-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
26
PsiBlast_CBE
95.38
46%
-100
- C2 -
4ZDI
1
PYRG_MYCTU
D:
[11-547]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
AAAA-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
4
PsiBlast_PDB
95.31
46%
-99
- C2 -
4ZDJ
4
PYRG_MYCTU
A:
[11-547]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
A
A
A
A
-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
-------------------
G
G
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
22
PsiBlast_CBE
95.27
46%
-100
- C2 -
4ZDI
1
PYRG_MYCTU
H:
[11-547]
----
K
H
L
F
V
S
G
G
-----
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
AAAA-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
---------------------
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
3
PsiBlast_PDB
95.20
46%
-101
- C2 -
4ZDI
1
PYRG_MYCTU
A:
[11-547]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
A
A
A
A
-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
--------------------
G
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
P
P
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
2
PsiBlast_PDB
95.13
46%
-98
- C2 -
4ZDK
4
PYRG_MYCTU
A:
[10-546]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
A
A
A
A
-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
-------------------
G
G
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
21
PsiBlast_CBE
94.70
46%
-98
- C2 -
4ZDK
4
PYRG_MYCTU
B:
[10-546]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
AAAA-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
-------------------
G
G
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
27
PsiBlast_CBE
94.46
46%
-98
- C2 -
4ZDI
1
PYRG_MYCTU
C:
[11-547]
----
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
--
Q
--
P
DADGNR
P
D
-------
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
G
C
E
T
-------------
T
--
S
G
A
A
A
A
-
L
G
D
-------------
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
--------------------
G
T
M
R
L
G
S
Y
P
A
-
V
L
-
E
P
D
S
V
V
A
Q
A
Y
Q
T
-
T
Q
V
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
-
T
-
S
P
D
G
H
-
L
V
E
F
V
E
Y
PP
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
----
29
PsiBlast_CBE
65.65
48%
-118
- C2 -
3IHL
2
PYRG2_HUMAN
B:
[2-272]
----
K
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
I
G
T
I
L
K
S
C
G
L
R
V
T
A
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
N
D
G
G
E
--------------------------------------------
V
Q
V
V
P
H
I
T
D
A
V
Q
E
W
V
M
N
Q
A
--
K
V-
P
------
V
D
GNKEEPQ
I
C
V
I
E
L
G
G
T
I
G
D
I
E
G
M
P
F
V
E
A
F
R
Q
F
Q
F
K
A
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
L
S
A
T
G
E
Q
K
T
K
P
T
Q
N
S
V
R
A
L
R
G
L
G
L
S
P
D
L
I
V
C
R
S
S
T
P
I
E
M
A
V
K
E
K
I
S
M
F
C
H
V
N
P
E
Q
V
I
C
I
H
D
V
S
S
T
Y
R
V
P
V
L
L
E
E
Q
S
I
V
K
Y
F
K
E
R
L
H
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
63.51
44%
-89
- C2 -
2V4U
-
PYRG2_HUMAN
A:
[296-550]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
C
S
I
A
L
V
G
K
Y
T
K
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
D
S
I
D
L
E
K
I
T
E
T
E
D
P
V
K
F
H
E
A
W
--
Q
K
-----
L
C
K
-------------
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
-
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
R
P
N
A
P
V
P
L
V
I
D
M
P
E
-----------
H
N
P
G
N
L
G
G
T
M
R
L
G
I
R
R
T
V
F
K
-
T
E
N
S
I
L
R
K
L
Y
G
D
V
P
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
-
Q
-
D
V
D
-
G
D
R
M
E
I
I
E
L
--
A
N
H
P
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
T
G
N
-----
5
PsiBlast_PDB
61.70
42%
-100
- C2 -
2VKT
-
PYRG2_HUMAN
A:
[301-547]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
L
V
G
K
Y
-
K
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
D
S
I
D
L
E
K
-------------
I
--
T
E
-----
T
E
D
P
V
K
F
H
E
A
W
Q
K
L
C
K
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
C
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
R
P
N
A
P
V
P
L
V
I
D
M
P
E
H
------------------
T
M
R
L
G
I
R
R
T
-
V
F
K
T
E
N
S
I
L
R
K
L
Y
G
D
V
P
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
-
Q
-
D
V
D
G
D
-
R
M
E
I
I
E
L
--
A
N
H
P
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
--------
6
PsiBlast_PDB
60.96
42%
-92
- C2 -
2V4U
-
PYRG2_HUMAN
A:
[301-547]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
L
V
G
K
Y
T
K
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
D
S
I
D
L
E
K
-------------
I
--
T
E
-----
T
E
D
P
V
K
F
H
E
A
W
Q
K
L
C
K
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
-
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
R
P
N
A
P
V
P
L
V
I
D
M
P
E
H
N
P
G
N
-----------
L
G
G
T
M
R
L
G
I
R
R
T
-
V
F
K
T
E
N
S
I
L
R
K
L
Y
G
D
V
P
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
-
Q
-
D
V
D
G
D
-
R
M
E
I
I
E
L
--
A
N
H
P
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
--------