@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0335: (2015-12-14 )
MKSKKLYLALIIGVLLAFLTLSSWLGNSGLVGRFGVWFAAINKKYFGYLSLINLPYLAWVLFLLYRAKNPFTEIVLEKTLGHLLGILSLLFLQSSLLNQGEIGNSARLFLHPFIGDFGLYVLIMLMVVISYLILFKLPPKSVFYPYMNKTQSLLKEIYKQCLQAFSPNFSLKKEGFENTPSDSQKKETNNDKEKENLKENPIDENHNTPNEESFLAIPTPYNTTLNNSEPQEGLVQISPHPPTHYTIYPKRNRFDDLTNPTLKEPKQETKEREPTLKKETPTTLKPIMPISASNTENHDKTENHKTPNHPIKEDDLQESPQENPQKENIEENIEEKETQNAPSFSPLTLTSAKKPVMVKELSENKEILDGLDYGEVQKPKDYELPTTQLLNAVCLKETSLDENEIDQKIQDLLSKLRTFKIDGDIIRTYSGPIVTTFEFRPAPSVKVSRILGLSDDLAMTLCAESIRIQAPIKGKDVVGIEIPNSQSQIIYLREILESELFQKSSSPLTLALGKDIVGNPFITDLKKLPHLLIAGTTGSGKSVGVNAMILSLLYKNPPDQLKLVMIDPKMVEFSIYADIPHLLTPIITDPKKAIGALQSVAKEMERRYSLMSEYKVKTIDSYNEQAQSNGVEAFPYLIVVIDELADLMMTGGKEAEFPIARIAQMGRASGLHLIVATQRPSVDVVTGLIKTNLPSRVSFRVGTKIDSKVILDTDGAQSLLGRGDMLFTPPGTNGLVRLHAPFATEDEIKKIVDFIKAQKEVEYDKDFLLEESRMPLDTPNYQGDDILERAKAVILEKKITSTSFLQRQLKIGYNQAATITDELEAQGFLSPRNAKGNREILQNF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240-........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520......------.530.......540.......550.......560.......570.......580...-----...--.590.....----..600.-......-610.......620...----------------....----------------------630--------------------.........640.......650.......660.......670.......680......---.690.......700.......710-----.......---720.......-730------........740-.......750.......760......--.770.......780.......790.......800.......810.......820.......830.......840..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKSK
K
L
Y
L
A
L
I
I
G
V
L
L
A
F
L
T
L
S
S
W
LGNSGLVG
R
F
G
V
W
F
A
A
IN
K
K
Y
F
G
Y
L
S
L
IN
L
P
Y
L
A
W
V
L
F
L
L
Y
RAKN
P
F
T
E
I
V
L
E
K
T
L
G
H
L
L
G
I
L
S
L
L
F
L
Q
S
S
LLNQGEIGNS
A
R
L
F
L
H
P
F
IG
D
F
G
L
Y
V
L
I
M
L
M
V
V
I
S
Y
L
I
LFKLP
P
K
S
V
F
Y
P
Y
M
N
K
T
Q
S
L
L
K
E
I
Y
K
Q
C
L
Q
AFSPNFSLKKEGFENTPSDSQKKETNN
D
K
E
K
ENLKENPIDENHNTPNEES
F
L
A
IPTPYNTTLNNSEPQE
G
L
V
Q
ISPHP--PT
H
Y
T
I
YPKRNRFDDLTNPTLKE
P
K
Q
E
T
K
EREPTLKKETPTTLKPIMPISASNTENHDKTENHKTPNHPIK
E
D
D
L
QESPQENP
Q
K
E
N
I
E
E
N
I
E
E
K
ETQNAPSFS
P
L
T
LTSAKK
P
V
M
V
K
E
LSEN
K
E
I
LDGLDYGEVQKPKDYEL
P
T
T
Q
L
L
N
A
V
CLKETSL
D
E
N
E
I
D
Q
K
I
Q
D
L
L
S
K
L
R
TFKIDG
D
I
I
R
TYSG
P
I
V
T
T
F
EFRPAPSV
K
V
S
R
I
LGLS
D
D
L
A
M
T
L
C
A
ES
I
R
I
QAPIKGK
D
V
V
G
I
EIPNSQ
S
Q
I
I
Y
L
R
E
I
L
E
S
E
L
F
QKSSS
P
L
T
L
A
LGKDIVGN
P
F
I
T
D
L
K
KL------P
H
L
L
I
AGTTGSGKSV
G
V
N
A
M
I
L
S
L
L
YKNP
P
D
Q
L
K
L
V
M
IDP
K
M
V
E
F
S
I
YAD
I
P
H
L
L
T
P
-----IIT--
D
P
K
K
A
I
G
A
L
----
Q
S
V
A
K
E
-
M
E
R
R
Y
S
-
L
M
S
EYKVKTIDS
Y
N
E
Q
----------------
A
Q
SN----------------------G----------------------VE
A
F
P
Y
L
I
V
V
I
D
E
L
A
D
L
M
MTGGKEAE
F
P
I
A
R
I
A
Q
MGRAS
G
L
H
L
I
V
ATQRP
S
V
D
V
V
T
G
L
---
I
KTNLPS
R
V
S
F
R
VGTKID
S
K
V
I
L
D-----TD
G
A
Q
S
L
---LGRG
D
M
L
FTP-PG-------TN
G
L
V
R
LHAPF-A
T
E
D
E
I
K
K
I
V
D
F
I
K
A
Q
K
EVEYD
K
D
F
L
--
L
EESRMPLDTPNYQ
G
D
D
I
L
E
R
A
K
A
V
I
L
EKKI
T
S
T
S
F
L
Q
R
Q
L
KIGYNQAA
T
I
T
D
E
L
E
AQGFLSPRNAKG
N
R
E
I
L
QNF
53
Fugue
95.26
48%
-96
- C2 -
2IUT
3
FTSK_PSEAE
A:
[70-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
----------------
V
K
D
A
----------------------
E
E
A
G
T
P
L
T
DPLFRRESPDDEPPQ
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
--
A
G
--------------------------------------------------------------------------
15
PsiBlast_CBE
94.37
46%
-98
- C2 -
2IUU
1
FTSK_PSEAE
F:
[70-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
VKD-------------
A
E
E
A
----------------------
G
TPLTDPLFRRESPDDEPPQ---
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
--
A
---------------------------------------------------------------------------
16
PsiBlast_CBE
94.10
46%
-98
- C2 -
2IUU
1
FTSK_PSEAE
E:
[70-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
VKD-------------
A
E
E
A
----------------------
G
TPLTDPLFRRESPDDEPPQ---
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
--
A
---------------------------------------------------------------------------
18
PsiBlast_CBE
93.91
46%
-98
- C2 -
2IUU
1
FTSK_PSEAE
C:
[70-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
VKD-------------
A
E
E
A
----------------------
G
TPLTDPLFRRESPDDEPPQ---
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
--
A
---------------------------------------------------------------------------
19
PsiBlast_CBE
93.54
46%
-99
- C2 -
2IUU
1
FTSK_PSEAE
B:
[70-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
VKD-------------
A
E
E
A
----------------------
G
TPLTDPLFRRESPDDEPPQ---
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
--
A
---------------------------------------------------------------------------
3
PsiBlast_PDB
93.34
46%
-98
- C2 -
2IUU
1
FTSK_PSEAE
A:
[70-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
-------------
A
E
E
A
----------------------
G
T
P
L
T
DPLFRRESPDD
E
P
P
Q
---
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
--
A
---------------------------------------------------------------------------
17
PsiBlast_CBE
93.30
46%
-99
- C2 -
2IUU
1
FTSK_PSEAE
D:
[70-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
VKD-------------
A
E
E
A
----------------------
G
TPLTDPLFRRESPDDEPPQ---
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
--
A
---------------------------------------------------------------------------
2
PsiBlast_PDB
92.89
43%
-98
- C- -
2IUT
3
FTSK_PSEAE
A:
[70-478]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
-------------
A
E
E
A
----------------------
G
T
P
L
T
DPLFRRESPDDEPPQ---
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
AG----------------------------------------------------------------------------
14
PsiBlast_CBE
92.64
43%
-97
- C- -
2IUT
3
FTSK_PSEAE
B:
[70-478]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
VKD-------------
A
E
E
A
----------------------
G
TPLTDPLFRRESPDDEPPQ---
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
AG----------------------------------------------------------------------------
25
HHSearch
90.96
45%
-30
- C- -
2IUT
3
FTSK_PSEAE
A:
[70-478]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
R
P
I
I
T
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
-----
V
V
T
--
D
M
K
E
A
A
N
A
L
----
R
W
S
V
A
E
-
M
E
R
R
Y
R
-
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
----------------
V
K
D
A
E
E
A
G
T
P
L
T
DPLFRRESPDDEPP
Q
----------------------
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
G
G
A
E
Q
L
---
L
G
H
G
D
M
L
Y
L
P
-
P
G
-------
T
G
L
P
I
R
V
H
G
A
F
-
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
--
A
G
--------------------------------------------------------------------------
26
HHSearch
89.99
46%
-33
- C- -
2IUS
-
FTSK_ECOLI
A:
[840-1249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
S
L
D
L
L
T
P
P
--------
T
F
A
L
E
Q
M
A
R
L
V
E
A
R
L
A
D
F
R
I
K
A
D
V
V
N
Y
S
P
G
P
V
I
T
R
F
E
L
N
L
A
P
G
V
K
A
A
R
I
S
N
L
S
R
D
L
A
R
S
L
S
T
V
A
V
R
V
V
E
V
I
P
G
K
P
Y
V
G
L
E
L
P
N
K
K
R
Q
T
V
Y
L
R
E
V
L
D
N
A
K
F
R
D
N
P
S
P
L
T
V
V
L
G
K
D
I
A
G
E
P
V
V
A
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
L
E
L
S
V
Y
E
G
I
P
H
L
L
T
E
-----
V
V
T
--
D
M
K
D
A
A
N
A
L
----
R
W
C
V
N
E
-
M
E
R
R
Y
K
-
L
M
S
A
L
G
V
R
N
L
A
G
Y
N
E
K
----------------
I
A
E
A
D
R
M
MRPIPDPYWH
P
--------
V
----------------------
L
K
K
E
P
Y
I
V
V
L
V
D
E
F
A
D
L
M
M
T
V
G
K
K
V
E
E
L
I
A
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
T
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
A
G
A
E
S
L
---
L
G
M
G
D
M
L
Y
S
G
-
P
N
-------
S
T
L
P
V
R
V
H
G
A
F
-
V
R
D
Q
E
V
H
A
V
V
Q
D
W
K
A
R
G
R
P
Q
Y
V
D
G
I
T
--
S
D
--------------------------------------------------------------------------
1
PsiBlast_PDB
88.97
44%
-33
- C- -
2IUS
-
FTSK_ECOLI
A:
[840-1249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
S
L
D
L
L
T
P
P
--------
T
F
A
L
E
Q
M
A
R
L
V
E
A
R
L
A
D
F
R
I
K
A
D
V
V
N
Y
S
P
G
P
V
I
T
R
F
E
L
N
L
A
P
G
V
K
A
A
R
I
S
N
L
S
R
D
L
A
R
S
L
S
T
V
A
V
R
V
V
E
V
I
P
G
K
P
Y
V
G
L
E
L
P
N
K
K
R
Q
T
V
Y
L
R
E
V
L
D
N
A
K
F
R
D
N
P
S
P
L
T
V
V
L
G
K
D
I
A
G
E
P
V
V
A
D
L
A
K
M
------
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
L
E
L
S
V
Y
E
G
I
P
H
L
L
T
E
-----
V
V
T
--
D
M
K
D
A
A
N
A
L
----
R
W
C
V
N
E
-
M
E
R
R
Y
K
-
L
M
S
A
L
G
V
R
N
L
A
G
Y
N
E
K
I
A
E
A
D
R
M
MRPIPDPYW--
H
P
----------------------
V
----------------------
L
K
K
E
P
Y
I
V
V
L
V
D
E
F
A
D
L
M
M
T
V
G
K
K
V
E
E
L
I
A
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
V
I
T
G
L
---
I
K
A
N
I
P
T
R
I
A
F
T
V
S
S
K
I
D
S
R
T
I
L
D
-----
Q
A
G
A
E
S
L
---
L
G
M
G
D
M
L
Y
S
G
-
P
N
-------
S
T
L
P
V
R
V
H
G
A
F
-
V
R
D
Q
E
V
H
A
V
V
Q
D
W
K
A
R
G
R
P
Q
Y
-
V
D
G
I
--
T
S
D
-------------------------------------------------------------------------
4
PsiBlast_PDB
59.91
28%
-77
- C2 -
4NH0
1
?
A:
[278-524]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
V
P
I
G
L
D
A
D
G
R
P
L
E
L
D
I
K
E
S
AQGGMG
P
H
G
L
C
I
G
A
T
G
S
G
K
S
E
L
L
R
T
L
V
L
A
L
A
M
T
H
S
P
E
V
L
N
F
V
L
V
D
F
K
G
G
A
T
F
L
G
M
E
G
L
R
H
V
S
A
-----
I
I
T
--
N
L
E
E
E
L
P
L
V
D
R
M
Y
D
A
L
H
G
E
-
M
V
R
R
Q
E
H
L
R
H
S
G
N
Y
A
S
L
R
D
Y
-
E
K
----------------
A
R
M
E
----------------------
G
A
P
--------------------
L
P
P
M
P
T
L
F
I
V
L
D
E
F
S
E
L
L
S
A
K
P
D
F
A
E
L
-
F
V
M
I
G
R
L
G
R
S
L
G
V
H
L
L
L
A
S
Q
R
L
E
E
G
K
L
R
G
L
----
D
T
H
L
S
Y
R
I
G
L
R
T
F
S
A
M
E
S
R
V
V
L
G
-----
V
P
D
A
Y
E
L
PPS
P
G
N
G
Y
L
K
F
A
-----------
T
E
P
L
V
R
F
K
A
A
Y
-
V
S
G
P
V
D
E
E
S
E
S
L
F
D
V
V
V
R
Q
L
A
G
H
G
P
E
--
P
H
Q
I
W
L
P
P
L
D
V
P
P
T
L
D
E
L
L
P
P
L
S
P
S
A
A
H
G
Y
T
A
D
G
W
E
W
R
G
R
L
H
A
V
V
G
L
V
D
R
P
F
D
Q
R
R
D
P
Y
W
L
D
L
S
G
G
A
G
H
V
G
V
A
G
G
P
57
Fugue
58.20
18%
-13
* C1 *
4UMW
2
?
A:
[124-730]
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
-----------------------
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
---------------------
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
----------------------------
A
S
R
V
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
N
G
E
R
E
E
V
A
I
-----------------------------
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
RL
P
A
D
G
K
L
L
S
P
F
A
S
F
D
E
---------
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
D
K
V
-----
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
A
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
--
H
P
A
T
G
I
S
E
S
E
L
L
T
L
A
A
A
V
E
Q
G
--
A
T
H
P
L
A
Q
A
I
V
R
E
A
Q
V
A
E
L
A
I
P
T
A
E
S
Q
R
A
L
V
G
S
G
I
E
A
Q
V
---
N
G
E
R
V
L
I
C
A
A
G
K
H
P
A
D
A
F
A
G
L
I
N
E
L
------
E
S
---------------
A
G
Q
T
V
V
L
V
V
R
N
D
-
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
-
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
GD
N
P
R
A
A
A
A
I
A
----
G
E
L
--
G
-
L
E
F
K
A
G
-
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
----------------
A
P
---------------------------------------------------------------
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
---------------------------------------------------
S
G
T
D
V
A
---
L
E
T
A
D
A
A
L
T
H
-
N
H
-------
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
L
------------------------------------
G
M
T
G
L
W
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
--------------
11
PsiBlast_PDB
50.59
24%
-91
- C2 -
4LYA
1
?
A:
[79-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
G
S
A
G
Y
G
K
S
T
T
M
M
T
L
L
L
S
F
A
G
A
Y
N
P
A
Q
L
H
Y
Y
I
F
D
F
G
N
S
A
L
L
P
L
R
Q
L
P
H
T
A
D
Y
-----
F
R
L
--
D
D
E
K
K
I
E
K
F
----
I
K
F
M
K
E
E
M
E
Q
R
K
Q
-
R
F
M
E
K
E
V
S
T
I
K
L
Y
N
A
L
----------------
S
E
------------------------------------------------
E
K
L
P
I
I
I
V
A
L
D
N
F
-
D
V
V
K
E
E
M
P
D
F
E
T
Q
L
I
Q
Y
A
R
D
G
Q
S
L
G
I
F
F
I
M
T
A
T
R
-----
V
S
G
I
R
P
P
L
M
N
N
L
K
T
K
I
---------
V
H
Y
F
I
D
-----
S
S
E
K
F
S
L
---
I
G
R
T
P
Y
D
V
D
P
I
P
G
R
A
L
I
K
KD
N
A
A
L
T
Q
I
Y
L
P
A
-
D
G
E
D
D
I
-
E
V
L
E
N
V
K
R
E
M
E
R
L
K
E
V
Y
Q
H
--
I
P
K
P
K
P
I
P
M
L
P
P
R
L
S
M
S
V
F
T
N
T
Y
V
Q
H
R
A
S
G
F
I
P
V
G
L
D
E
Q
T
V
R
P
V
A
I
N
M
R
T
D
P
H
C
L
I
V
G
Q
S
R
K
G
K
T
N
V
V
K
V
I
L
E
S
L
L
56
Fugue
42.49
14%
-55
- C2 -
4KFU
6
?
A:
[2-206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
D
------
D
I
V
V
L
V
G
R
K
K
S
G
K
S
Y
L
I
K
H
Y
F
I
P
V
L
K
A
H
---
K
I
S
Y
I
I
D
D
H
N
L
L
R
S
G
S
E
Y
S
K
F
G
Y
N
A
T
-----
S
L
S
--
D
I
V
S
K
Q
Y
V
V
----
V
Y
D
R
A
K
-
N
D
D
F
F
E
-
K
L
W
Q
A
S
K
L
H
S
K
K
Y
G
T
------------------------------------------------------------------------
T
V
L
I
I
D
E
-
A
Y
Y
H
F
K
Y
K
Q
K
V
T
P
A
I
D
E
A
L
H
A
N
R
H
A
G
L
G
L
I
L
S
T
Q
R
V
Y
D
--
L
M
P
I
---
V
Y
K
Q
A
D
L
I
I
M
F
Y
T
R
E
P
N
E
L
R
W
I
S
K
YIS
A
E
A
A
E
K
V
K
T
---
L
K
Q
Y
H
F
L
I
Y
D
-
V
N
-------
S
-
Q
T
I
K
I
H
K
P
I
-
L
E
------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
42.28
25%
-49
- C2 -
4N1A
3
?
A:
[374-519]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
Y
L
D
F
N
T
D
------
P
H
F
L
V
F
G
D
T
E
C
G
K
S
N
L
L
R
L
I
T
A
G
I
I
E
R
Y
T
P
Q
Q
A
R
L
I
F
I
D
--------
Y
S
R
--
S
L
L
D
V
-----
A
T
T
--
E
H
Q
I
G
Y
A
A
S
----
S
T
A
A
S
S
-
L
V
R
D
I
K
-
G
A
M
E
A
R
L
P
P
P
D
L
T
P
E
Q
----------------
L
R
S
R
----------------------
S
----------------------
W
W
T
G
A
E
L
F
L
V
V
D
D
Y
E
--
M
V
A
T
S
D
N
P
L
R
P
L
A
E
L
L
P
Q
A
R
D
I
G
L
H
L
I
I
A
R
S
M
G
G
A
G
R
A
L
Y
E
---
P
I
I
Q
R
I
K
E
M
A
S
P
G
L
V
M
S
G
N
K
D
E
G
I
-----
L
L
G
N
V
K
P
---
H
K
L
P
Q
G
R
G
Y
F
-
V
E
-------
R
R
S
G
T
R
L
I
Q
T
A
-
Y
R
E
S
----------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
41.39
36%
41
- C2 -
2VE9
2
FTSK_PSEAE
B:
[9-66]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
Y
D
E
A
V
R
F
V
T
E
S
R
R
A
S
I
S
A
V
Q
R
K
L
K
I
G
Y
N
R
A
A
R
M
I
E
A
M
E
M
A
G
V
V
T
P
M
N
T
N
G
S
R
E
V
I
A
P
A
5
PsiBlast_PDB
41.34
44%
32
- C2 -
2J5P
-
FTSK_ECOLI
A:
[1266-1323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
F
D
Q
A
V
Q
F
V
T
E
K
R
K
A
S
I
S
G
V
Q
R
Q
F
R
I
G
Y
N
R
A
A
R
I
I
E
Q
M
E
A
Q
G
I
V
S
E
Q
G
H
N
G
N
R
E
V
L
---
7
PsiBlast_PDB
40.57
36%
35
- C2 -
2VE9
2
FTSK_PSEAE
A:
[8-66]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
L
Y
D
E
A
V
R
F
V
T
E
S
R
R
A
S
I
S
A
V
Q
R
K
L
K
I
G
Y
N
R
A
A
R
M
I
E
A
M
E
M
A
G
V
V
T
P
M
N
T
N
G
S
R
E
V
I
A
P
A