@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0341: (2015-12-14 )
MPKKCRHLLQTSDLSLDEIKLLLNKASVYANDFNAVSLETREKMQDKIIVALFFENSTRTVSSFEIASLRLGAKIVKLNMQTSSTSKGETLIDTFKNIHAMQPDAIITRHAFSSAPFKLAEFSQCPLINAGSGTSAHPTQALLDLLTLYRHFGSLENLKGKKIAFIGDVKNSRVANSNIKLLQRLGLEIMLCAPSSMLPITPLKTTHNIEEAIGFADILMSLRTQTERHNAPIFASLKDYGNAYCITQKRLETHAKNKEVIILHPGPVHRDIDIESAVLEDKRSKVLEQVKNGVAMRMAVLEFLLLD
Atome Classification :
(58 SA)
.........10........20......-..30........40....-----....50........60........70.......-.--80.........90........100.......110......-.120.-......130.......140.......150.......160.......170.......180...-....190.....-.-.----200..----------.---------..----------.-------..210.......220.......230.......240-.........250.......260.......270.......280.......290.......300.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
P
K
K
C
R
H
L
L
Q
TSDL
S
L
D
E
I
K
L
L
L
N
K
A
S
-VYANDF
N
A
V
S
L
E
T
R
E
KMQ-----D
K
I
I
V
A
L
F
FENST
R
T
V
S
S
F
E
I
A
S
L
RLG
A
K
I
V
K
L
-
N
--
M
-QTSSTSK
G
E
T
L
I
D
T
F
K
N
I
HAMQPD
A
I
I
TRHAFSSAPFK-LAEFS-QC
P
L
INAGSGTSAH
P
T
Q
A
L
L
D
L
L
T
L
Y
R
H
FG
S
L
E
NLKG
K
K
I
A
F
I
GDVKNSRVAN
S
N
I
K
L
L
Q
RL-G
L
E
I
M
L
CAPSSM-L-P----IT-PL----------K---------TT----------H-------
N
I
E
E
A
I
G
F
A
D
I
L
M
S
L
R
TQTERHNA
P
I
F
A
S
L
K
DY---G
N
A
Y
C
I
T
Q
K
R
L
E
THAKNK
E
V
I
I
LHPGPVHRDID
I
E
S
A
V
L
E
D
K
R
S
K
V
L
E
Q
V
KN
G
V
A
M
R
M
A
V
L
E
F
L
LLD
111
HHSearch
97.65
39%
-105
- C9 -
3R7F
7
PYRB_BACSU
A:
[1-291]
----
M
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
S
G
-
K
-----
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
-
N
--
T
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
-
D
----
E
E
N
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
--
V
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
-
M
K
R
-
H
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
3
PsiBlast_PDB
94.30
37%
-101
- C9 -
3R7F
7
PYRB_BACSU
A:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
26
PsiBlast_CBE
93.01
37%
-100
- C9 -
3R7F
7
PYRB_BACSU
C:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
27
PsiBlast_CBE
92.55
37%
-103
- C9 -
3R7F
8
PYRB_BACSU
B:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
28
PsiBlast_CBE
91.79
37%
-105
- C9 -
3R7D
4
PYRB_BACSU
C:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
29
PsiBlast_CBE
91.06
37%
-103
- C9 -
3R7D
2
PYRB_BACSU
B:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
46
PsiBlast_CBE
91.00
32%
-110
- C9 -
2RGW
1
PYRB_METJA
E:
[1-302]
----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
-
K
M
E
E
L
L
N
--
T
K
R
P
L
K
L
L
E
-----
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
--
L
-
K
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
-
A
S
E
Y
S
-
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
---
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
-
P
KDI-
I
E
-
D
L
----------
K
---------
A
K
----------
N
IKFYEKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
--
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
----
G
K
K
F
I
I
M
H
P
L
P
R
V
D
E
I
D
Y
D
V
D
D
L
--
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
45
PsiBlast_CBE
90.91
32%
-109
- C9 -
2RGW
1
PYRB_METJA
F:
[1-302]
----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
-
K
M
E
E
L
L
N
--
T
K
R
P
L
K
L
L
E
-----
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
--
L
-
K
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
-
A
S
E
Y
S
-
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
---
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
-
P
KDI-
I
E
-
D
L
----------
K
---------
A
K
----------
N
IKFYEKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
--
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
----
G
K
K
F
I
I
M
H
P
L
P
R
V
D
E
I
D
Y
D
V
D
D
L
--
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
48
PsiBlast_CBE
90.80
32%
-110
- C9 -
2RGW
1
PYRB_METJA
C:
[1-302]
----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
-
K
M
E
E
L
L
N
--
T
K
R
P
L
K
L
L
E
-----
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
--
L
-
K
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
-
A
S
E
Y
S
-
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
---
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
-
P
KDI-
I
E
-
D
L
----------
K
---------
A
K
----------
N
IKFYEKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
--
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
----
G
K
K
F
I
I
M
H
P
L
P
R
V
D
E
I
D
Y
D
V
D
D
L
--
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
49
PsiBlast_CBE
90.70
32%
-110
- C9 -
2RGW
1
PYRB_METJA
B:
[1-302]
----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
-
K
M
E
E
L
L
N
--
T
K
R
P
L
K
L
L
E
-----
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
--
L
-
K
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
-
A
S
E
Y
S
-
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
---
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
-
P
KDI-
I
E
-
D
L
----------
K
---------
A
K
----------
N
IKFYEKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
--
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
----
G
K
K
F
I
I
M
H
P
L
P
R
V
D
E
I
D
Y
D
V
D
D
L
--
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
2
PsiBlast_PDB
90.58
37%
-98
- C9 -
3R7D
3
PYRB_BACSU
A:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
T
4
PsiBlast_PDB
90.47
37%
-96
- C9 -
3R7L
3
PYRB_BACSU
A:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
41
PsiBlast_CBE
90.41
32%
-103
- C9 -
3E2P
1
PYRB_METJA
E:
[1-302]
----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
-
K
M
E
E
L
L
N
--
T
K
R
P
L
K
L
L
E
-----
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
--
L
-
K
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
-
A
S
E
Y
S
-
Q
V
P
I
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
---
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
-
P
KDI-
I
E
-
D
L
----------
K
---------
A
K
----------
N
IKFYEKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
--
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
----
G
K
K
F
I
I
M
H
P
L
P
R
V
D
E
I
D
Y
D
V
D
D
L
--
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
47
PsiBlast_CBE
90.40
32%
-110
- C9 -
2RGW
1
PYRB_METJA
D:
[1-302]
----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
-
K
M
E
E
L
L
N
--
T
K
R
P
L
K
L
L
E
-----
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
--
L
-
K
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
-
A
S
E
Y
S
-
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
---
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
-
P
KDI-
I
E
-
D
L
----------
K
---------
A
K
----------
N
IKFYEKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
--
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
----
G
K
K
F
I
I
M
H
P
L
P
R
V
D
E
I
D
Y
D
V
D
D
L
--
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
11
PsiBlast_PDB
90.12
32%
-108
- C9 -
2RGW
1
PYRB_METJA
A:
[1-302]
----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
-
K
M
E
E
L
L
N
--
T
K
R
P
L
K
L
L
E
-----
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
--
L
-
K
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
-
A
S
E
Y
S
-
Q
V
P
I
I
N
A
G
----
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
---
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
-
P
K
D
I
-
I
E
-
D
L
----------
K
---------
A
K
----------
N
I
K
F
Y
E
K
E
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
--
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
----
G
K
K
F
I
I
M
H
P
L
P
R
V
D
E
I
D
Y
D
V
D
D
L
--
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
24
PsiBlast_CBE
90.07
37%
-98
- C9 -
3R7L
3
PYRB_BACSU
C:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
23
PsiBlast_CBE
89.83
37%
-99
- C9 -
3R7L
3
PYRB_BACSU
D:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
22
PsiBlast_CBE
89.59
37%
-97
- C9 -
3R7L
3
PYRB_BACSU
E:
[2-286]
-----
K
H
L
T
T
M
S
E
L
S
T
E
E
I
K
D
L
L
Q
T
A
Q
-
E
L
K
------
S
G
K
T
D
N
Q
L
T
-----
G
K
F
A
A
N
L
F
F
E
P
S
T
R
T
R
F
S
F
E
V
A
E
K
K
L
G
M
N
V
L
N
L
-
D
--
G
-
T
S
T
S
V
Q
K
G
E
T
L
Y
D
T
I
R
T
L
E
S
I
G
V
D
V
C
V
I
R
H
S
E
D
E
Y
Y
E
E
-
L
V
S
Q
V
-
N
I
P
I
L
N
A
G
D
G
C
G
Q
H
P
T
Q
S
L
L
D
L
M
T
I
Y
E
E
F
N
T
---
F
K
G
L
T
V
S
I
H
G
D
I
K
H
S
R
V
A
R
S
N
A
E
V
L
T
R
L
-
G
A
R
V
L
F
S
G
P
S
E
W
-
Q
D
E
----
E
N
-
T
F
----------
G
---------
T
Y
----------
V
-------
S
M
D
E
A
V
E
S
S
D
V
V
M
L
L
R
I
Q
N
E
R
H
Q
S
A
V
--
S
Q
E
G
Y
---
L
N
K
Y
G
L
T
V
E
R
A
E
R
M
K
R
H
--
A
I
I
M
H
P
A
P
V
N
R
G
V
E
I
D
D
S
L
V
E
S
E
K
S
R
I
F
K
Q
M
K
N
G
V
F
I
R
M
A
V
I
Q
R
A
L
Q
-
13
PsiBlast_PDB
89.56
32%
-102
- C9 -
4EKN
6
PYRB_METJA
B:
[1-302]
----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
-
K
M
E
E
L
L
N
--
T
K
R
P
L
K
L
L
E
-----
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
--
L
-
K
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
-
A
S
E
Y
S
-
Q
V
P
I
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
---
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
-
P
KDI-
I
E
-
D
L
----------
K
---------
A
K
----------
N
IKFYEKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
--
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
----
G
K
K
F
I
I
M
H
P
L
P
R
V
D
E
I
D
Y
D
V
D
D
L
--
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
39
PsiBlast_CBE
89.53
32%
-102
- C9 -
3E2P
1
PYRB_METJA
I:
[1-302]
----
M
K
H
L
I
S
M
K
D
I
G
K
E
E
I
L
E
I
L
D
E
A
R
-
K
M
E
E
L
L
N
--
T
K
R
P
L
K
L
L
E
-----
G
K
I
L
A
T
V
F
Y
E
P
S
T
R
T
R
L
S
F
E
T
A
M
K
R
L
G
G
E
V
I
T
M
T
D
--
L
-
K
S
S
S
V
A
K
G
E
S
L
I
D
T
I
R
V
I
S
G
Y
A
-
D
I
I
V
L
R
H
P
S
E
G
A
A
R
L
-
A
S
E
Y
S
-
Q
V
P
I
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
M
R
E
I
G
R
I
D
---
G
I
K
I
A
F
V
G
D
L
K
Y
G
R
T
V
H
S
L
V
Y
A
L
S
L
F
E
N
V
E
M
Y
F
V
S
P
K
E
L
R
L
-
P
KDI-
I
E
-
D
L
----------
K
---------
A
K
----------
N
IKFYEKE
S
L
D
D
L
D
D
D
I
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
P
--
N
E
Y
E
K
V
---
K
G
S
Y
K
I
K
R
E
Y
V
E
----
G
K
K
F
I
I
M
H
P
L
P
R
V
D
E
I
D
Y
D
V
D
D
L
--
P
Q
A
K
Y
F
K
Q
S
F
Y
G
I
P
V
R
M
A
I
L
K
K
L
I
E
D
6
PsiBlast_PDB
88.83
33%
-101
- C9 -
3D6N
1
PYRB_AQUAE
B:
[2-290]
-----
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
-----
Y
A
K
E
F
K
----
E
G
K
E
E
T
I
-----
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
--
G
-
S
E
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
K
E
I
V
K
S
L
-
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
---
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
K
T
L
-
I
-
P
RDVE
V
F
-
K
V
----------
D
---------
V
F
----------
D
-------
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
S
E
S
S
Y
---
F
K
Q
F
G
L
T
K
E
R
F
E
-----
K
V
K
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
T
-
8
PsiBlast_PDB
87.79
35%
-102
- C9 -
1ML4
1
PYRB_PYRAB
A:
[2-305]
-
D
W
K
G
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
--------
E
R
L
E
R
E
L
K
E
K
G
Q
LEYAK
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
A
E
--
A
-
S
T
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
V
I
V
I
R
H
P
K
E
G
A
A
R
L
-
A
A
E
V
A
-
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
G
R
I
D
G
L
---
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
E
L
L
R
M
-
P
R
H
I
-
V
E
-
E
L
----------
R
E
K
GMK
V
V
--
E
T
----------
T
-------
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
-----
F
P
D
E
Q
E
Y
L
K
V
K
G
S
Y
Q
V
N
L
K
V
L
E
K
-
A
K
D
-
E
L
R
I
M
H
P
L
P
--
R
V
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
V
5
PsiBlast_PDB
87.50
33%
-102
- C9 -
4BJH
14
PYRB_AQUAE
B:
[32-321]
----
M
R
S
L
I
S
S
L
D
L
T
R
E
E
V
E
E
I
L
K
-----
Y
A
K
E
F
K
----
E
G
K
E
E
T
I
-----
K
A
S
A
V
L
F
F
S
E
P
S
T
R
T
R
L
S
F
E
K
A
A
R
E
L
G
I
E
T
Y
L
V
-
S
--
G
-
S
E
S
S
T
V
K
G
E
S
F
F
D
T
L
K
T
F
E
G
L
G
F
D
Y
V
V
F
R
V
P
F
V
F
F
P
Y
K
E
I
V
K
S
L
-
N
L
R
L
V
N
A
G
D
G
T
H
Q
H
P
S
Q
G
L
I
D
F
F
T
I
K
E
H
F
G
E
V
K
D
L
R
---
V
L
Y
V
G
D
I
K
H
S
R
V
F
R
S
G
A
P
L
L
N
M
F
-
G
A
K
I
G
V
C
G
P
K
T
L
-
I
-
P
RDVE
V
F
-
K
V
----------
D
---------
V
F
----------
D
-------
D
V
D
K
G
I
D
W
A
D
V
V
I
W
L
R
L
Q
K
E
R
Q
K
E
N
Y
I
P
S
E
S
S
Y
---
F
K
Q
F
G
L
T
K
E
R
F
E
-----
K
V
K
L
Y
M
H
P
G
P
V
N
R
N
V
D
I
D
H
E
L
V
Y
T
E
K
S
L
I
Q
E
Q
V
K
N
G
I
P
V
R
K
A
I
Y
K
F
L
W
T
-
113
HHSearch
86.81
36%
-89
- C9 -
1ML4
1
PYRB_PYRAB
A:
[2-307]
-
D
W
K
G
R
D
V
I
S
I
R
D
F
S
K
E
D
I
E
T
V
L
A
T
A
E
-
R
L
E
R
E
-
L
K
E
-
K
G
Q
L
E
Y
A
K
-----
G
K
I
L
A
T
L
F
F
E
P
S
T
R
T
R
L
S
F
E
S
A
M
H
R
L
G
G
A
V
I
G
F
-
A
--
E
A
S
T
S
S
V
K
K
G
E
S
L
R
D
T
I
K
T
V
E
Q
Y
-
C
D
V
I
V
I
R
H
P
K
E
G
A
A
R
L
-
A
A
E
V
A
-
E
V
P
V
I
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
Y
T
I
K
K
E
F
-
G
--
R
I
D
G
L
K
I
G
L
L
G
D
L
K
Y
G
R
T
V
H
S
L
A
E
A
L
T
F
Y
-
D
V
E
L
Y
L
I
S
P
E
L
L
-
R
-
M
----
P
R
H
I
V
E
E
L
R
E
K
GMK
V
V
---------
E
T
----------
T
-------
T
L
E
D
V
I
G
K
L
D
V
L
Y
V
T
R
I
Q
K
E
R
F
P
D
E
Q
--
E
Y
L
K
V
---
K
G
S
Y
Q
V
N
L
K
V
L
E
K
-
A
K
D
-
E
L
R
I
M
H
P
L
P
R
V
--
D
E
I
H
P
E
V
D
N
T
K
H
A
I
Y
F
R
Q
V
F
N
G
V
P
V
R
M
A
L
L
A
L
V
L
G
V
15
PsiBlast_PDB
84.24
33%
-95
- C9 -
3LXM
1
PYRB_YERPE
A:
[28-329]
-
P
L
Y
H
K
H
I
I
S
I
N
D
L
S
R
D
E
L
E
L
V
L
R
T
A
A
-------
S
L
K
K
T
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
I
H
R
L
G
A
S
V
V
G
F
-
S
D----------
G
E
T
L
A
D
T
M
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
S
R
L
-
A
A
Q
F
S
G
N
V
P
I
V
N
A
G
D
G
A
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
I
---
N
I
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
N
G
N
H
F
F
F
I
A
P
D
A
L
A
M
-
P
----
A
Y
-
I
L
----------
Q
---------
M
L
E
E
K
E
I
E
Y
S
L
H
E
-------
S
L
E
E
V
V
P
E
L
D
I
L
Y
M
T
R
----------
Y
A
N
V
K
-------
A
Q
F
I
L
R
S
S
D
L
T
G
A
R
D
N
-
L
K
V
L
H
P
L
P
--
R
I
D
E
I
T
T
D
V
D
K
T
P
Y
A
Y
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
A
16
PsiBlast_PDB
84.18
33%
-84
- C9 -
1D09
1
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
E
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
86
PsiBlast_CBE
83.81
33%
-92
- C9 -
1R0C
2
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
85
PsiBlast_CBE
83.80
33%
-93
- C9 -
1R0C
2
PYRB_ECOLI
G:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
84
PsiBlast_CBE
83.78
33%
-93
- C9 -
1ZA2
3
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
83
PsiBlast_CBE
83.74
33%
-89
- C9 -
1ZA2
2
PYRB_ECOLI
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
82
PsiBlast_CBE
83.68
33%
-96
- C9 -
2AIR
2
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
77
PsiBlast_CBE
83.12
33%
-90
- C9 -
2FZG
1
PYRB_ECOLI
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
75
PsiBlast_CBE
82.82
33%
-89
- C9 -
2FZK
1
PYRB_ECOLI
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
81
PsiBlast_CBE
82.68
33%
-89
- C9 -
2AIR
2
PYRB_ECOLI
G:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
78
PsiBlast_CBE
82.47
33%
-86
- C9 -
2FZG
1
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
80
PsiBlast_CBE
82.42
33%
-87
- C9 -
2FZC
1
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
79
PsiBlast_CBE
82.40
33%
-90
- C9 -
2FZC
1
PYRB_ECOLI
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
99
PsiBlast_CBE
82.18
33%
-87
- C9 -
8ATC
1
PYRB_ECOLI
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
E
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
100
PsiBlast_CBE
82.15
33%
-84
- C9 -
8ATC
1
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
Q
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
E
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
E
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
76
PsiBlast_CBE
81.98
33%
-88
- C9 -
2FZK
1
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
64
PsiBlast_CBE
81.83
33%
-85
- C9 -
4KGV
1
?
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
52
PsiBlast_CBE
81.77
33%
-84
- C9 -
1D09
1
PYRB_ECOLI
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
Q
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
E
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
58
PsiBlast_CBE
81.70
33%
-86
- C9 -
4KH0
1
?
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
73
PsiBlast_CBE
81.60
33%
-83
- C9 -
2H3E
1
PYRB_ECOLI
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
56
PsiBlast_CBE
81.59
33%
-86
- C9 -
4KH1
1
?
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
54
PsiBlast_CBE
81.57
33%
-87
- C9 -
1EKX
3
PYRB_ECOLI
C:
[4-305]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
62
PsiBlast_CBE
81.49
33%
-83
- C9 -
4KGX
1
?
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
63
PsiBlast_CBE
81.39
33%
-86
- C9 -
4KGX
1
?
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
65
PsiBlast_CBE
81.35
33%
-87
- C9 -
4KGV
1
?
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
55
PsiBlast_CBE
81.33
33%
-89
- C9 -
1EKX
3
PYRB_ECOLI
B:
[4-305]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
57
PsiBlast_CBE
81.22
33%
-85
- C9 -
4KH1
2
?
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
71
PsiBlast_CBE
81.19
33%
-86
- C9 -
2IPO
4
PYRB_ECOLI
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
67
PsiBlast_CBE
81.01
33%
-88
- C9 -
4F04
1
PYRB_ECOLI
C:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
MLDEKGIAW
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
68
PsiBlast_CBE
80.93
33%
-85
- C9 -
4F04
1
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
18
PsiBlast_PDB
80.91
33%
-87
- C9 -
1EKX
2
PYRB_ECOLI
A:
[4-305]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
72
PsiBlast_CBE
80.79
33%
-86
- C9 -
2IPO
2
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
74
PsiBlast_CBE
80.49
33%
-84
- C9 -
2H3E
1
PYRB_ECOLI
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R
59
PsiBlast_CBE
80.18
33%
-87
- C9 -
4KH0
1
?
A:
[3-304]
-
P
L
Y
Q
K
H
I
I
S
I
N
D
L
S
R
D
D
L
N
L
V
L
A
T
A
A
K
L
K
A
N
-------
P
Q
P
E
L
L
K
-----
H
K
V
I
A
S
C
F
F
E
A
S
T
R
T
R
L
S
F
E
T
S
M
H
R
L
G
A
S
V
V
G
F
-
S
DS
A
-
N
T
S
L
G
K
K
G
E
T
L
A
D
T
I
S
V
I
-
S
T
Y
V
D
A
I
V
M
R
H
P
Q
E
G
A
A
R
L
-
A
T
E
F
S
G
N
V
P
V
L
N
A
G
D
G
S
N
Q
H
P
T
Q
T
L
L
D
L
F
T
I
Q
E
T
Q
G
R
L
D
N
L
---
H
V
A
M
V
G
D
L
K
Y
G
R
T
V
H
S
L
T
Q
A
L
A
K
F
D
G
N
R
F
Y
F
I
A
P
D
A
L
A
M
-
P
----
Q
Y
-
I
L
----------
D
M
L
D
E
K
G
I
A
W
S
L
----------
H
S------
S
I
E
E
V
M
A
E
V
D
I
L
Y
M
T
R
V
Q
K
E
R
L
D
P
S
E
Y
A
N
V
K
------
A
Q
F
V
L
R
A
S
D
L
H
N
A
K
A
N
M
K
V
--
L
H
P
L
P
--
R
V
D
E
I
A
T
D
V
D
K
T
P
H
A
W
Y
F
Q
Q
A
G
N
G
I
F
A
R
Q
A
L
L
A
L
V
L
N
R