@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0349: (2015-12-14 )
MDILKTLQKHLGDVETSDFKTNAIEKSQQIAKFSRDMKNINESVGALQVLQIACKKLLNKSMGLEDKDALQASIIKQELREIVENCQFLASPLFDTQLNIAINDEVFSMIVDNPLNLLENVGGFQAYLEEKLNEIKELLGYLSESLSNPKAFMPKQSFSNKSLKDLLSDDLRA
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------.........10--........20..-------.......30-..---------......40.-.......---.50.......-.60----.......--------..----------------70...-.....80........90......-.---.--.100...-....110.......120..---.....130.-......140.........150.-......160........170.----------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------M
D
I
L
K
T
L
Q
K
H
L--GDVETSDFK-T
N
-------
A
I
E
K
S
Q
Q
I
A
-
K
F
---------
S
R
D
M
K
N
I
-
N
-
E
S
V
G
A
L
Q
---
V
L
Q
I
A
C
K
K
L
L
-
N
K
-----SMGL
E
D
K
--------
D
A
----------------
L
Q
A
S
I
-
I
K
Q
E
L
R
E
I
V
E
N
C
Q
F
L
A-SPLFD
T
-
Q
---
L
--
N
I
A
I
N
D
E
-
V
F
S
M
I
VD
N
P
L
N
L
L
E
NV
G
G
F
---
Q
A
Y
L
E
E
K
L
N
-
E
I
K
E
L
L
G
--
Y
L
S
E
SLSNPKAFM-PKQSFS
N
K
-
S
L
K
D
L
L
S
D
DLRA----------------------------------------------------------------------------------------------------------------
25
HHSearch
100.00
94%
-150
- C3 -
3K1I
-
?
C:
[28-146]
----------------------------------------------------------------------------------------------------------------------------------
Q
Q
I
A
-
K
F
---------
S
R
D
M
K
N
I
-
N
-
E
S
V
G
A
L
Q
---
V
L
Q
I
A
C
K
K
L
F
-
N
K
-----
S
M
G
L
E
D
K
--------
D
A
----------------
L
Q
A
S
I
-
I
K
Q
E
L
R
E
I
V
E
N
C
Q
F
L
A
-
S
P
L
F
D
T
-
Q
---
L
--
N
I
A
I
N
D
E
-
I
F
S
M
I
V
V
N
P
L
D
L
L
E
N
V
G
E
F
---
Q
A
Y
L
E
E
K
L
N
-
E
I
K
E
L
L
G
--
Y
L
S
E
S
L
---------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
100.00
94%
-150
- C3 -
3K1I
-
?
C:
[28-146]
----------------------------------------------------------------------------------------------------------------------------------
Q
Q
I
A
-
K
F
---------
S
R
D
M
K
N
I
-
N
-
E
S
V
G
A
L
Q
---
V
L
Q
I
A
C
K
K
L
F
-
N
K
-----
S
M
G
L
E
D
K
--------
D
A
----------------
L
Q
A
S
I
-
I
K
Q
E
L
R
E
I
V
E
N
C
Q
F
L
A
-
S
P
L
F
D
T
-
Q
---
L
--
N
I
A
I
N
D
E
-
I
F
S
M
I
V
V
N
P
L
D
L
L
E
N
V
G
E
F
---
Q
A
Y
L
E
E
K
L
N
-
E
I
K
E
L
L
G
--
Y
L
S
E
S
L
---------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
95.96
95%
-149
- C3 -
3K1H
-
?
A:
[33-147]
----------------------------------------------------------------------------------------------------------------------------------------
F
---------
S
R
D
M
K
N
I
-
N
-
E
S
V
G
A
L
Q
---
V
L
Q
I
A
C
K
K
L
F
-
N
K
-----
S
M
G
L
E
D
K
--------
D
A
----------------
L
Q
A
S
I
-
I
K
Q
E
L
R
E
I
V
E
N
C
Q
F
L
A
-
S
P
L
F
D
T
-
Q
---
L
--
N
I
A
I
N
D
E
-
I
F
S
M
I
V
V
N
P
L
D
L
L
E
N
V
G
E
F
---
Q
A
Y
L
E
E
K
L
N
-
E
I
K
E
L
L
G
--
Y
L
S
E
S
L
S
--------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
95.74
95%
-149
- C3 -
3K1H
-
?
A:
[33-147]
----------------------------------------------------------------------------------------------------------------------------------------
F
---------
S
R
D
M
K
N
I
-
N
-
E
S
V
G
A
L
Q
---
V
L
Q
I
A
C
K
K
L
F
-
N
K
-----
S
M
G
L
E
D
K
--------
D
A
----------------
L
Q
A
S
I
-
I
K
Q
E
L
R
E
I
V
E
N
C
Q
F
L
A
-
S
P
L
F
D
T
-
Q
---
L
--
N
I
A
I
N
D
E
-
I
F
S
M
I
V
V
N
P
L
D
L
L
E
N
V
G
E
F
---
Q
A
Y
L
E
E
K
L
N
-
E
I
K
E
L
L
G
--
Y
L
S
E
S
L
S
--------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.53
94%
-149
- C3 -
3K1H
-
?
A:
[33-147]
----------------------------------------------------------------------------------------------------------------------------------------
F
---------
S
R
D
M
K
N
I
-
N
-
E
S
V
G
A
L
Q
---
V
L
Q
I
A
C
K
K
L
F
-
N
K
-----
S
M
G
L
E
D
K
--------
D
A
----------------
L
Q
A
S
I
-
I
K
Q
E
L
R
E
I
V
E
N
C
Q
F
L
A
-
S
P
L
F
D
T
-
Q
---
L
--
N
I
A
I
N
D
E
-
I
F
S
M
I
V
V
N
P
L
D
L
L
E
N
V
G
E
F
---
Q
A
Y
L
E
E
K
L
N
-
E
I
K
E
L
L
G
--
Y
L
S
E
S
L
S
--------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
50.79
17%
-10
- C2 -
2R9G
1
?
A:
[12-197]
------------------------------------------------------------------------------------------DA
H
Y
D
V
I
S
A
F
Q
K
S
I
R
G
S
D
V
D
A
A
L
H
Y
-
L
A
-------
R
L
V
E
A
G
D
L
A
-
S
I
---------
C
R
R
L
M
V
I
G
Y
-
E
D
I
G
L
G
N
-----
P
A
A
A
A
R
T
V
-
N
A
-----
V
L
A
A
E
K
L
--------
G
L
----------------
P
E
A
----
R
I
P
L
A
D
V
V
V
D
L
C
L
S
P
K
S
N
S
A
Y
M
-
A
---
L
--
D
A
A
L
A
D
I
-
R
E
G
K
A
G
D
V
P
D
H
L
R
D
S
H
Y
N
R
---
G
V
G
Y
Q
Y
P
H
H
-
F
D
Q
A
W
V
N
QQ
Y
L
P
D
K
L
K
N
A
Q
Y
Y
Q
-
P
K
D
T
G
K
Y
E
-
Q
A
L
G
Q
Q
Y
Y
R
I
K
E
W
K
E-------------------------------------------------------------------------------------------------------------
39
Fugue
50.53
14%
-43
* C2 *
3ZPJ
-
?
A:
[1-356]
M
T
T
L
E
E
I
N
L
L
V
E
R
GY
Y
E
E
A
L
A
K
V
YEIED
P
I
E
Q
V
Q
V
L
T
K
I
V
V
T
I
Y
Q
H
DGPMEW
I
P
S
I
M
E
D
A
M
Y
I
A
K
K
LRD
P
A
N
K
A
V
A
Y
S
I
I
A
S
T
L
A
I
M
EY
E
E
D
A
M
D
F
F
N
R
A
I
D
E
A
--
N
E
I
E
-------
S
-------
P
I
E
K
G
M
V
L
S
-
T
L
---------
A
Y
H
L
A
I
A
-
G
-
Y
P
D
N
A
L
E
---
I
F
N
I
A
F
D
T
I
I
-
G
A
-----
E
--------------------------------
T
S
Y
T
H
-
K
V
D
G
I
L
R
I
G
D
L
L
E
K
A
G
-
D
T
L
-
P
S
-
N
---
E
--
A
M
D
F
Y
K
M
-
A
F
D
I
F
D
K
L
------
H
V
N
Q
R
---
A
A
I
V
E
K
K
I
E
-
L
A
K
T
V
Y
D
---
V
G
L
P
Q
I
R
A
A
L
L
K
-
G
K
N
H
Y
A
L
A
-
I
I
K
K
K
Y
S
G
V
M
R
L
I
G
E
L
E
V
A
L
W
M
K
R
V
NNME
Y
L
D
V
V
D
K
A
F
E
C
CESPRFT
D
V
N
V
Q
H
I
A
R
L
L
T
E
L
GN
L
R
R
A
L
K
F
A
K
E
IQN
I
H
K
R
S
E
A
L
K
A
I
A
L
E
L
V
R
R
KKFEE
V
K
K
I
I
E
S
IPD
P
K
I
R
E
E
A
L
N
E
I
GTIE
28
HHSearch
48.21
14%
-69
- C3 -
1IO1
-
FLIC_SALTY
A:
[56-158]
-----------------------------------------------------------------------------------------------------------------------------------
N
I
K
-
G
L
---------
T
Q
A
S
R
N
A
-
N
-
D
G
I
S
I
A
Q
---
T
T
E
G
A
L
N
E
I
N
-
N
N
-----
L
Q
R
V
R
E
L
--------
A
V
Q
S
A
NSTNS
Q
S
D
L
D
S
I
Q
A
E
I
T
Q
-
R
L
N
E
I
D
R
V
S
G
Q
T
Q
F
N
G
-
V
K
V
L
A
Q
-
D
N
T
-
L
--
T
I
Q
V
G
A
N
D
G
E
T
I
D
I
D
L
K
Q
I
N
S
Q
T
L
G
L
D
---
T
L
N
V
Q
Q
K
Y
K
-
V
S
D
T
A
A
T
--
V
T
G
Y
A
D
T
T
I
A
L
D
N
-
S
T
F
K
A
S
A
T
-
G
L
G
G
T
D
Q
K
I
D
G
D
----------------------------------------------------------------------------------------------------------------
38
Fugue
46.61
11%
-71
- C3 -
3MFN
1
?
A:
[31-155]
--------------------------------------------------------------------------------------------A
Q
E
A
V
I
E
A
K
R
Y
L
--
N
N
A
K
D
I
-
L
R
-
D
K
-------
G
G
K
E
D
-----
G
F
---------
Y
Q
D
S
K
Y
V
-
K
M
A
G
H
T
A
Y
S
---
G
V
L
F
A
L
D
H
Y
F
G
K
K
-----
T
K
G
R
K
D
V
--------
D
W
----------------
Y
K
S
N
L
-
A
Q
Q
D
-
K
K
I
L
N
T
F
V
S
V
Y
-
E
Q
L
H
L
V
M
A
---
Y
--
D
G
V
G
D
-------------------------
A
E
V
V
K
L
G
F
Q
-
R
A
E
I
I
I
D
--
W
V
E
R
R
L
A
A
-------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
45.54
12%
-31
- C3 -
1UCU
-
FLIC_SALTY
A:
[40-149]
----------------------------------------------------------------------------------------------------------
A
K
D
D
A
A
G
Q
A
-
I
A
-------
N
-
R
F
T
A
N
I
K
-
G
L
---------
T
Q
A
S
R
N
A
-
N
-
D
G
I
S
I
A
Q
---
T
T
E
G
A
L
N
E
I
N
-
N
N
-----
L
Q
R
V
R
E
L
--------
A
V
Q
S
A
NSTNS
Q
S
D
L
D
S
I
Q
A
E
I
T
Q
-
R
L
N
E
I
D
R
V
S
G
Q
T
Q
F
N
G
-
V
K
V
L
A
Q
-
D
N
T
-
L
--
T
I
Q
V
G
A
N
-
D
G
E
T
I
D
I
D
L
K
Q
I
N
S
Q
T
L
G
L
---
D
T
L
N
V
Q
Q
K
Y
-
K
V
S
D
T
A
A
--
T
V
T
G
Y
A
D
T
T
I
A
L
D
-
N
S
T
F
K
A
S
A
-
T
G
L
G
G
T
D
Q
K
I
D
G
----------------------------------------------------------------------------------------------------------------
27
HHSearch
43.72
14%
-36
- C3 -
3K8W
-
?
A:
[44-151]
-------------------------------------------------------------------------------------------------------------
D
A
A
G
L
A
-
I
S
-------
D
-
R
M
T
A
Q
I
K
-
G
L
---------
T
Q
A
Q
R
N
A
-
N
-
D
G
I
S
L
A
Q
---
T
A
E
G
A
L
G
E
I
S
-
N
N
-----
L
Q
R
I
R
E
L
--------
A
V
Q
A
S
NGTNT
Q
T
D
R
D
A
L
Q
A
E
V
T
Q
-
L
Q
S
E
I
Q
R
V
A
E
Q
T
S
F
N
G
-
Q
K
L
L
D
G
-
S
FN
G
V
--
Q
F
Q
I
G
A
N
-
A
G
E
T
I
G
V
S
K
I
M
N
A
Q
T
A
S
L
G
---
G
S
L
T
R
T
T
S
T
-
I
D
A
T
D
L
T
--
K
Y
D
T
A
M
A
A
G
D
L
T
I
-
N
G
V
D
V
G
K
I
-
D
A
A
S
T
A
Q
E
R
A
A
Q
----------------------------------------------------------------------------------------------------------------
32
HHSearch
42.43
13%
-62
* C3 *
3V47
-
FLIC_SALDU
C:
[24-109]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
R
N
A
-
N
-
D
G
I
S
I
A
Q
---
T
T
E
G
A
L
N
E
I
N
-
N
N
-----
L
Q
R
V
R
E
L
--------
S
V
Q
A
T
NGTNS
D
S
D
L
K
S
I
Q
D
E
I
Q
Q
-
R
L
E
E
I
D
R
V
S
N
Q
T
Q
F
N
G
-
V
K
V
L
S
Q
-
D
---
N
Q
M
K
I
Q
V
G
A
N
-
D
G
E
T
I
T
I
D
L
Q
K
I
D
V
K
S
L
G
L
---
D
G
F
N
V
N
G
P
K
-
E
A
T
V
G
D
L
--
K
S
S
F
K
N
V
T
G
Y
D
T
Y
-
A
A
G
A
D
K
Y
R
-
V
D
I
N
S
G
A
V
V
T
D
A
----------------------------------------------------------------------------------------------------------------
36
Fugue
42.33
18%
-14
- C3 -
2WCR
2
?
A:
[1-147]
---------------------------------------------------------------------------------------------
N
S
F
L
Q
D
V
P
Y
W
M
--
L
Q
-
N
R
S
E
Y
I
-
T
Q
-------
G
V
D
S
S
H
I
V
D
G
K
K
---------
T
E
E
I
E
K
I
-
A
-
T
K
R
A
T
I
R
---
V
A
Q
N
I
V
H
K
L
K
-
E
A
-----
Y
L
S
K
T
N
R
--------------------------------
I
K
Q
K
------------------------------
I
T
N
E
-
M
F
I
Q
M
T
Q
P
I
Y
D
S
L
M
N
V
D
R
L
---
G
I
Y
I
N
P
N
N
E
-
E
V
F
A
L
V
R
--
A
R
G
F
D
K
D
A
L
S
E
G
L
-
H
K
M
S
L
D
N
Q
-
A
V
S
I
L
V
A
K
V
E
E
I
F
K
D
S------------------------------------------------------------------------------------------------------------
43
Fugue
42.12
20%
7
- C2 -
1U6T
1
SH3L1_HUMAN
A:
[1-121]
-----------------------------------------------------------------------------------------------
V
I
R
V
Y
I
A
---------
S
S
S
G
-
S
T
-------
A
I
K
K
K
Q
Q
D
V
-
L
G
---------
F
L
E
A
N
K
I
---------------------------------
G
F
E
E
K
--------
D
I
----------------
A
A
N
E
E
-
N
R
K
W
M
R
E
N
V
P
E
N
S
R
P
A
-
T
G
Y
P
L
P
------------------
P
Q
I
F
N
E
S
----
Q
Y
R
G
D
Y
---
D
A
F
F
E
A
R
E
N
N
A
V
Y
A
F
L
G
--
L
T
A
P
P
G
S
K
E
A
E
V
Q
-
A
K
Q
Q
A
L
E
H
-
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------
42
Fugue
37.82
16%
-3
- C2 -
4YMR
-
?
A:
[11-144]
-----------------------------------------------------------------------------------------------
V
L
P
E
L
R
R
A
Q
--
S
L
T
C
T
G
L
-
Y
-
R
E
-------
A
L
A
L
W
A
N
A
W
-
Q
L
---------
Q
T
Q
L
G
T
P
-
S
-
G
P
D
R
P
L
L
---
T
L
A
G
L
A
V
C
H
Q
-
E
---------
L
E
D
P
--------
G
E
----------------
A
R
A
C
S
-
E
K
A
L
Q
L
L
G
D
K
R
P
H
P
F
L
-
A
P
F
L
E
A
-
H
---
V
--
R
L
S
W
R
------------------
L
G
L
D
---
K
R
Q
S
E
A
Q
L
Q
-
A
L
Q
E
-----------------
A
-
G
L
T
S
T
P
P
P
-
S
L
K
E
L
L
I
K
E
V
L
D
----------------------------------------------------------------------------------------------------------------
37
Fugue
35.22
10%
-39
- C2 -
3I3N
1
KLH11_HUMAN
A:
[1-274]
-----------------------------------------------YFQSME
A
E
D
F
E
CSS
H
C
S
E
L
S
W
R
Q
N
E
Q
R
R
Q
GLFCD
I
T
L
C
FG
R
E
F
R
A
H
R
S
V
L
A
A
A
T
E
Y
F
--
T
P
L
L
S
G
R
V
E
M
R
K
WSSEPGP
E
P
D
T
V
E
A
V
I
-
E
Y
M
Y
TG
R
I
R
V
S
T
G
S
V
H
E
V
-
L
-
E
L
A
D
R
F
L
L
I
R
L
K
E
F
C
G
E
F
L
K
-
K
K
LHLSN
C
V
A
I
H
S
L
A
H
M
Y
TL
S
Q
L
A
----------------
L
K
A
A
D
M
I
R
R
N
F
H
K
V
I
Q
D
E
E
F
Y
T
-
L
P
----------------
F
H
L
-
I
R
D
W
L
S
D
L
E
I
T
V
D
S
E
E
V
L
F
---
E
T
V
L
K
W
V
Q
R
-
N
A
E
E
R
E
R
--
Y
F
E
E
L
F
K
L
L
R
L
S
Q
M
K
P
T
Y
L
T
R
H
V
K
P
E
R
L
V
A
N
N
E
V
C
V
K
L
V
A
D
A
V
E
R
H
A
L
R
AEN-----------------------------------------------------------------------------------------------
30
HHSearch
33.94
7%
-29
- C3 -
3PWX
1
?
A:
[5-103]
------------------------------------------------------------------------------------------------------------
D
D
P
M
A
S
I
-
K
L
--------
L
N
L
E
R
E
N
S
-
A
I
---------
A
Q
Y
Q
S
N
I
-
A
-
N
L
K
T
T
L
S
---
S
Q
E
T
H
L
D
S
V
S
-
E
S
-----
L
K
S
M
R
D
I
--------
V
L
W
G
ANGSLTDQDR
S
G
M
I
T
E
L
K
S
-
Y
R
D
S
I
E
S
S
F
N
A
Q
D
E
E
G
-
H
F
L
F
S
G
-
T
---
K
--
T
D
T
A
A
L
N
-
K
S
S
G
A
Y
V
V
E
G
N
S
D
V
R
V
V
T
V
---
A
K
G
V
T
M
D
S
N
-
M
T
A
Q
E
I
L
--
D
I
G
G
G
K
N
V
L
N
Q
I
D
-
A
L
I
A
E
F
E
K
-
P
S
P
N
F
Q
A
E
V
D
A
S
----------------------------------------------------------------------------------------------------------------
31
HHSearch
33.92
10%
-36
- C3 -
2D4X
-
FLGL_SALTY
A:
[50-139]
------------------------------------------------------------------------------------------------------------------------------
V
V
L
S
Q
A
Q
A
-
Q
N
---------
S
Q
Y
A
L
A
R
-
T
-
F
A
T
Q
K
V
S
---
L
E
E
S
V
L
S
Q
V
T
-
T
A
-----
I
Q
T
A
Q
E
K
--------
I
V
Y
A
GNGTLS
D
D
D
R
A
S
L
A
T
D
L
Q
G
-
I
R
D
Q
L
M
N
L
A
N
S
T
D
G
N
G
-
R
Y
I
F
A
G
-
Y
---
K
--
T
E
A
A
P
F
D
-
Q
A
T
G
G
Y
H
G
G
E
K
S
V
T
Q
Q
V
D
S
---
A
R
T
M
V
I
G
H
T
-
G
A
Q
I
F
N
S
--
I
T
S
N
A
V
P
E
P
D
G
S
D
-
S
E
K
N
L
F
V
M
-
L
D
T
A
I
A
A
L
K
T
P
V
----------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
32.11
36%
-74
- C4 -
2PW9
-
?
A:
[33-80]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
T
-
P
---
Y
--
A
I
A
L
N
D
R
-
V
I
G
S
S
M
V
L
P
V
D
L
E
E
F
G
A
G
F
L
F
G
Q
G
Y
I
-
K
K
A
E
-
E
I
R
E
I
L
V
--
C
P
Q
G
R
I
S
V
Y
A
D
K
I
-
P
K
E
M
L
E
E
F
-
A
P
L
A
D
Y
C
L
P
F
A
E
----------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
28.47
44%
-114
- C4 -
3VVK
1
BACH_NATPH
A:
[18-44]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
-
T
Q
R
E
L
F
E
F
V
L
N
D
P
L
L
A
-
S
S
L
Y
-------
I
--
N
I
A
L
A
G
L
-
S
I
L
L
F
V
F
M
T
R
G
L
D
D
P
R
A
K
L
---
I
A
V
S
T
I
L
V
P
-
V
V
S
I
A
S
Y
--
T
G
L
A
S
G
L
T
I
S
V
L
E
-
M
P
A
G
H
F
A
E
-
G
S
S
V
M
L
G
G
E
E
V
D
----------------------------------------------------------------------------------------------------------------