@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0353: (2015-12-14 )
MKESFYIEGMTCTACSSGIERSLGRKSFVKKIEVSLLNKSANIEFNENETNLDEIFKLIEKLGYSPKKTLAEEKKEFFSPNVKLALAVIFTLFVVYLSMGAMLSPSLLPESLLTINHHSNFLNACLQLIGALIVMHLGRDFYIQGFKALWHRQPNMSSLIAIGTSAALISSLWQLYLVYTNHYTDQWSYGHYYFESVCVILMFVMVGKRIENVSKDKALDAMQALMKNAPKTALKMHNNQQIEVLVDSIVVGDILKVLPGSAIAVDGEIIEGEGELDESMLSGEALPVYKKVGDKVFSGTLNSNTSFLMKATQDNKNSTLSQIIEMIHNAQSSKAEISRLADKVSSVFVPSVIAIAVLAFVVWLIIAPKPDFWWNFRTALEVFVSVLVISCPCALGLATPMSILVANQKASSLGLFFKDAKSLEKARLVNTIVFDKTGTLTNGKPVVKSIHSNIELLELLSLASSIEKSSEHVIAKGIVEYAKERNAPLKDISEVKVKTGFGISAKVDYQGAKEIIKVGNSEFFNPINTLEIKENGILVFVGRAINEKEDELLGAFVLEDLPKKGVKEHIAQIKNLGINTFLLSGDNRENVKKCALELGIDGYISNAKPQDKLNKIKELKEKGRIVMMVGDGLNDAPSLAMSDVAVVMAKGSDVSVQAADIVSFNNDIKSVYSAIKLSQATIKNIKENLFWAFCYNSVFIPLACGVLYKANIMLSPAIAGLAMSLSSVSVVLNSQRLRNFKIKDH
Atome Classification :
(27 SA)
.........10........20........30........40........50........60.....---....70....---....80........90........100.......110......-.120.-......130-----..-.-......140.......150.......160.......170---.....--...180.......190.......200.......210.......220.......230-.....-...240...-....250.......260.......270..---.....280.......290-----------.....----------....300.......310.......320.......330.......340.......350.......360.......370...--.----...380.......390.......400.......410.......420.......430.......440..-----.-....-450------------------------------------.--.-.------------------------.....--.460..----------------...-----------------..470.......480-------------------........490.....-------..500......-------------.510--------------......-----------------.-----.---.--520--....--------...--..530----.-----....--...-540-------.........550-----------------........560.......570.......580.......590.......600---------------------------------------------------..-------------------------------......-----------------------------.610.......620.......630.......640......-.650.......660.......670.......680.......690.-......700.......-710------------.......-----------.720.....--..730.......740...-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKE
S
F
Y
IE
G
M
T
C
T
A
C
S
S
G
I
E
R
S
L
G
R
K
S
F
V
K
K
I
E
V
S
LLNKSA
N
I
E
FNENET
N
L
D
E
I
F
K
L
I
E
-KLGYS---
P
K
K
T
L
A
E
E
K
K
---
E
FFSPN
V
K
L
A
L
A
V
I
F
T
L
F
V
V
Y
L
S
M
G
A
ML
S
P
S
LL
P
E
S
L
L
TINHH-
S
N
F
L
N
-
A
C
L
Q
L
I
G
-------
A
L
-
I
-
V
M
HLG
R
D
F
Y
I
Q
G
F
K
A
L
W
HRQP
N
M
S
S
L
I
A
IG
T
S
A
A
L
I
S
S
----
L
W
Q
L
Y
--
L
V
Y
TNHYTDQWS
Y
G
H
Y
Y
F
E
S
V
C
V
I
L
M
F
V
M
V
G
K
R
I
E
NV
S
K
D
K
A
L
D
A
M
Q
A
L
M
KNA
P
K
--
T
A
LKM-HNN
Q
Q
I
E
V
L
-
V
D
S
I
V
V
G
D
I
L
K
VLPG
S
A
I
A
VD
G
E
I
IEGEG---EL
D
E
S
MLSGEA
L
P
V
Y
K
-------------
K
VGD
K
----------
V
F
S
G
TLNSN
T
S
F
L
M
K
ATQDNKN
S
T
L
S
Q
I
I
E
M
I
HNAQS
S
K
A
E
I
S
R
L
A
D
K
V
S
S
V
F
V
P
S
V
I
A
I
A
V
L
A
F
V
V
W
L
IIAPKP
D
F
W
W
N
--
F
----
R
T
A
L
E
V
F
V
S
V
L
V
ISCPCALGLAT
P
M
S
I
L
V
ANQKASSL
G
L
F
F
K
D
A
K
S
L
E
K
A
R
L
V
N
T
I
V
FDKTGTLTN
G
K
-----
P
-
V
V
K
S
-
I
--------------------------------------H--S-
N
------------------------
I
E
L
L
E
--
L
L
S
L
A
S
----------------
S
I
E
-----------------KSS
E
H
V
I
A
K
G
I
V
E
Y
--------------------
A
K
ERNAP
L
K
D
I
S
E
V
K
V
-------KTGFG
I
S
A
K
V
D-------------YQ----------------
G
A
K
E
I
I
-----------------K-----V---G--N----SEFF--------NPI--
N
T
L
E
-----
I
-----KEN
G
--
I
L
V
-
F
---------VGRAIN
E
K
E
D
E
------------------
L
L
G
A
F
V
L
E
DL
P
K
K
G
V
K
E
H
I
A
Q
I
K
NLGI
N
T
F
L
LSGD
N
R
E
N
V
K
K
C
A
L
E
LGI-----------------------------------------------------DG-------------------------------YISNAK-----------------------------
P
Q
D
K
L
N
K
I
K
E
L
K
EKG
R
I
V
M
M
VGDGLNDA
P
S
L
A
M
S
D
V
A
V
V
M
-AKGS
D
V
S
V
Q
A
A
D
I
VSFN
N
D
I
K
S
V
Y
S
A
I
K
L
S
Q
A
T
I
K
N
I
K
E
N
L
F
W
A
F
-
C
YNS
V
F
I
P
L
A
C
G
V
L
Y
K
-
A
-
N
------------
I
M
L
S
P
A
I
-----------
A
G
L
A
M
S
L
S
S
--
V
S
V
V
L
N
S
Q
R
LRNFKIKDH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Fugue
85.84
37%
-91
- C3 -
3RFU
3
?
A:
[74-736]
----------------------------------------------------------------------------
V
S
P
---
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
G
L
K
H
F
I
S
----------
G
N
G
S
S
-
W
I
Q
L
L
L
A
-------
T
P
-
V
-
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
----
M
V
A
V
L
WP
G
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
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A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
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Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
--
S
A
H
R
I
-
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
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L
L
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R
P
G
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K
I
P
V
D
G
E
V
Q
E
G
R
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
----
A
--
L
----
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
-----
P
-
K
L
T
R
-
I
--------------------------------------
V
--
T
D
D
------------------------
F
V
E
D
N
--
A
L
A
L
A
A
----------------
A
L
E
-----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
--------------------
A
K
E
K
G
L
S
L
G
S
V
E
A
F
E
A
-------
P
T
G
K
G
V
V
G
Q
V
D
GH
H
V
---------
A
I
----------------
G
N
A
R
L
M
-----------------
Q
-----
E
H
G
G
D
--
N
----
A
P
L
F
--------
E
K
A
--
D
E
L
R
-----
G
-----
K
G
A
S
--
V
M
F
-
M
---------
A
V
------
D
G
K
------------------
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-------------------------------
V
V
A
E
I
M
-----------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
-
L
-
T
G-----------
L
L
L
S
P
M
I
-----------
A
A
A
A
M
A
L
S
S
--
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.37
34%
-84
- C3 -
3J09
-
COPA_ARCFU
A:
[16-728]
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
-
D
L
G
Y
G
V
VD
E
Q
A
A
V
S
A
E
V
E
---
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
--
F
I
S
---
L
P
--------
Y
-
E
D
F
V
-----
Q
L
L
I
-------
A
L
P
A
-
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
----
V
L
S
T
A
--
G
V
L
P
R
E
Y
S
--------
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
--
T
A
V
V
I
-
R
D
G
K
E
I
A
V
P
-
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
-------------
S
K
G
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
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V
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A
M
G
S
K
P
P
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R
L
A
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V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
A
P
L
L
F
-----------
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
E
V
T
D
L
-
V
--------------------------------------
P
--
L
-
N
------------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
D
G
I
-------------
L
V
----------------
G
N
K
R
L
M
-----------------
E
D
F
G
V
-
A
---
V
--
S
----
N
E
V
E
--------
L
A
L
--
E
K
L
E
-----------
R
E
A
K
--
T
A
V
-
I
---------
V
A
R
-----
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
-
I
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
-
I
F
G
------------
V
V
F
R
P
E
F
-----------
A
G
L
A
M
A
M
S
S
--
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
84.58
35%
-78
- C3 -
3J09
-
COPA_ARCFU
A:
[16-733]
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
-
D
L
G
Y
G
---
V
V
D
E
Q
A
A
V
S
A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
---------
S
L
---------
P
Y
E
-
D
F
V
Q
L
L
I
-------
A
L
-
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
----
V
L
S
T
A
--
G
V
--------
L
P
R
E
Y
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
--
T
A
V
V
I
-
R
D
G
K
E
I
A
V
P
-
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
-------------
S
K
G
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
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K
L
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D
A
M
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K
P
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L
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L
L
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A
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H
-
A
P
L
L
F
----------
A
F
T
T
L
I
A
V
L
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V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
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G
M
G
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G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
-
E
V
T
D
-
L
--------------------------------------
V
--
P
-
L
N-----------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
-------------------------------------
D
G
I
-----------------
L
-----
V
---
G
--
N
----
K
R
L
M
--------
E
D
F
--
G
V
A
V
S
N
E
V
E
L
-----
A
L
E
K
--
L
E
R
E
A
---------
K
T
A
V
I
V
A
R
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
-
I
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
I
F
-
G
------------
V
V
F
R
P
E
F
-----------
A
G
L
A
M
A
M
S
S
--
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.57
37%
-83
- C3 -
4BYG
4
?
A:
[77-736]
----------------------------------------------------------------------------------
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
-----------
G
L
K
H
F
I
S
G
N
G
S
-
S
W
I
Q
L
L
L
-------
A
T
P
V
-
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
P
G
----
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
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T
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L
V
L
L
G
Q
V
L
E
L
K
A
R
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S
A
I
R
A
L
L
K
L
V
P
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--
S
A
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E
D
G
S
E
E
E
V
S
-
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
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K
I
P
V
D
G
E
V
Q
E
G
R
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
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D
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A
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--
L
----
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A
A
----
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V
L
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C
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A
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T
L
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-----
P
-
K
L
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R
-
I
--------------------------------------
V
--
T
-
D
-------------------------
D
F
V
E
D
N
A
L
A
L
A
A
----------------
A
L
E
-----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
--------------------
A
K
E
K
G
L
S
L
G
S
V
E
A
F
E
A
-------
P
T
G
K
G
V
V
G
Q
V
D
-------------
G
H
H
V
A
I
G
-----------
N
A
R
L
M
Q
-----------------
E
-----
H
---
G
G
D
N
----
A
P
L
F
--------
E
K
A
--
D
E
L
R
-----
G
-----
K
G
A
S
--
V
M
F
-
M
------------
A
V
D
G
K
T
V
A
------------------
L
L
---
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-------------------------------
V
V
A
E
I
M
-----------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
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S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
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L
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E
S
T
M
S
N
I
R
Q
N
L
F
F
A
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-
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N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
-
G
------------
L
L
L
S
P
M
I
-----------
A
A
A
A
M
A
L
S
S
--
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.40
37%
-82
- C3 -
4BEV
2
?
A:
[77-736]
----------------------------------------------------------------------------------
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
-----------
G
L
K
H
F
I
S
G
N
G
S
-
S
W
I
Q
L
L
L
-------
A
T
P
V
-
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
P
G
----
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
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T
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L
V
L
L
G
Q
V
L
E
L
K
A
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T
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S
A
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R
A
L
L
K
L
V
P
E
--
S
A
H
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E
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S
E
E
E
V
S
-
L
D
N
V
A
V
G
D
L
L
R
V
R
P
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K
I
P
V
D
G
E
V
Q
E
G
R
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
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L
A
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I
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Q
M
V
S
D
A
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R
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R
A
P
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R
L
A
D
T
V
S
G
W
F
V
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A
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I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
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Q
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A
L
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Y
G
--
L
----
I
A
A
----
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S
V
L
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I
A
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C
A
L
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L
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M
S
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V
G
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N
A
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A
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R
M
E
K
V
N
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V
V
D
K
T
G
T
L
T
E
G
H
-----
P
-
K
L
T
R
-
I
--------------------------------------
V
--
T
-
D
-------------------------
D
F
V
E
D
N
A
L
A
L
A
A
----------------
A
L
E
-----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
--------------------
A
K
E
K
G
L
S
L
G
S
V
E
A
F
E
A
-------
P
T
G
K
G
V
V
G
Q
V
D
-------------
G
H
H
V
A
I
G
-----------
N
A
R
L
M
Q
-----------------
E
-----
H
---
G
G
D
N
----
A
P
L
F
--------
E
K
A
--
D
E
L
R
-----
G
-----
K
G
A
S
--
V
M
F
-
M
------------
A
V
D
G
K
T
V
A
------------------
L
L
---
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-------------------------------
V
V
A
E
I
M
-----------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
-
G
------------
L
L
L
S
P
M
I
-----------
A
A
A
A
M
A
L
S
S
--
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
83.13
37%
-84
- C3 -
3RFU
3
?
C:
[77-736]
----------------------------------------------------------------------------------
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
-----------
G
L
K
H
F
I
S
G
N
G
S
-
S
W
I
Q
L
L
L
-------
A
T
P
V
-
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
MVAV
L
W
P
G
----
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
--
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
-
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
--
L
----
I
A
A
----
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
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G
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L
I
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N
A
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A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
-----
P
-
K
L
T
R
-
I
--------------------------------------
V
--
T
-
D
-------------------------
D
F
V
E
DN
A
L
A
L
A
A
----------------
A
L
E
-----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
--------------------
A
K
E
K
G
L
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L
G
S
V
E
A
F
E
A
-------
P
T
G
K
G
V
V
G
Q
V
D
-------------
G
H
HVAIG-----------
N
A
R
L
M
Q
-----------------
E
-----
H
---
G
GD
N
----
A
P
L
F
--------
E
K
A
--
D
E
L
R
-----
G
-----
K
G
A
S
--
V
M
F
-
M
------------
A
V
D
G
K
T
V
A
------------------
L
L
---
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-------------------------------
V
V
A
E
I
M
-----------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
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A
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-
G
T
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T
D
V
A
I
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S
A
G
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T
L
L
H
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L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
-
G
------------
L
L
L
S
P
M
I
-----------
A
A
A
A
M
A
L
S
S
--
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.11
37%
-84
- C3 -
3RFU
3
?
B:
[77-736]
----------------------------------------------------------------------------------
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
-----------
G
L
K
H
F
I
S
G
N
G
S
-
S
W
I
Q
L
L
L
-------
A
T
P
V
-
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
MVAV
L
W
P
G
----
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
--
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
-
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
--
L
----
I
A
A
----
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
-----
P
-
K
L
T
R
-
I
--------------------------------------
V
--
T
-
D
-------------------------
D
F
V
E
DN
A
L
A
L
A
A
----------------
A
L
E
-----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
--------------------
A
K
E
K
G
L
S
L
G
S
V
E
A
F
E
A
-------
P
T
G
K
G
V
V
G
Q
V
D
-------------
G
H
HVAIG-----------
N
A
R
L
M
Q
-----------------
E
-----
H
---
G
GD
N
----
A
P
L
F
--------
E
K
A
--
D
E
L
R
-----
G
-----
K
G
A
S
--
V
M
F
-
M
------------
A
V
D
G
K
T
V
A
------------------
L
L
---
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-------------------------------
V
V
A
E
I
M
-----------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
-
G
------------
L
L
L
S
P
M
I
-----------
A
A
A
A
M
A
L
S
S
--
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.99
37%
-84
- C3 -
3RFU
3
?
D:
[77-736]
----------------------------------------------------------------------------------
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
-----------
G
L
K
H
F
I
S
G
N
G
S
-
S
W
I
Q
L
L
L
-------
A
T
P
V
-
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
MVAV
L
W
P
G
----
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
--
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
-
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
--
L
----
I
A
A
----
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
-----
P
-
K
L
T
R
-
I
--------------------------------------
V
--
T
-
D
-------------------------
D
F
V
E
DN
A
L
A
L
A
A
----------------
A
L
E
-----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
--------------------
A
K
E
K
G
L
S
L
G
S
V
E
A
F
E
A
-------
P
T
G
K
G
V
V
G
Q
V
D
-------------
G
H
HVAIG-----------
N
A
R
L
M
Q
-----------------
E
-----
H
---
G
GD
N
----
A
P
L
F
--------
E
K
A
--
D
E
L
R
-----
G
-----
K
G
A
S
--
V
M
F
-
M
------------
A
V
D
G
K
T
V
A
------------------
L
L
---
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-------------------------------
V
V
A
E
I
M
-----------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
-
G
------------
L
L
L
S
P
M
I
-----------
A
A
A
A
M
A
L
S
S
--
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.99
37%
-84
- C3 -
3RFU
3
?
A:
[77-736]
----------------------------------------------------------------------------------
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
H
-----------
G
L
K
H
F
I
S
G
N
G
S
-
S
W
I
Q
L
L
L
-------
A
T
P
V
-
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
P
G
----
V
F
P
H
A
F
R
S
Q
E
G
V
V
A
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
--
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
-
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
S
---
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
Q
P
A
L
S
Y
G
--
L
----
I
A
A
----
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
-----
P
-
K
L
T
R
-
I
--------------------------------------
V
--
T
-
D
-------------------------
D
F
V
E
D
N
A
L
A
L
A
A
----------------
A
L
E
-----------------
H
Q
S
E
H
P
L
A
N
A
I
V
H
A
--------------------
A
K
E
K
G
L
S
L
G
S
V
E
A
F
E
A
-------
P
T
G
K
G
V
V
G
Q
V
D
-------------
G
H
H
V
A
I
G
-----------
N
A
R
L
M
Q
-----------------
E
-----
H
---
G
G
D
N
----
A
P
L
F
--------
E
K
A
--
D
E
L
R
-----
G
-----
K
G
A
S
--
V
M
F
-
M
------------
A
V
D
G
K
T
V
A
------------------
L
L
---
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
K
-------------------------------
V
V
A
E
I
M
-----------------------------
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
-
G
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
-
I
Y
N
V
L
G
V
P
L
A
A
G
V
L
Y
P
L
T
-
G
------------
L
L
L
S
P
M
I
-----------
A
A
A
A
M
A
L
S
S
--
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
75.33
36%
-78
- C3 -
3J08
-
COPA_ARCFU
A:
[97-732]
-------------------------------------------------------------------------------------
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
---------
S
L
---------
P
Y
E
-
D
F
V
Q
L
L
I
-------
A
L
-
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
----
V
L
S
T
A
--
G
V
--------
L
P
R
E
Y
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
--
T
A
V
V
I
-
R
D
G
K
E
I
A
V
P
-
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
-------------
S
K
G
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
-
A
P
L
L
F
----------
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
-
E
V
T
D
-
L
--------------------------------------
V
--
P
-
L
N-----------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
-------------------------------------
D
G
I
-----------------
L
-----
V
---
G
--
N
----
K
R
L
M
--------
E
D
F
--
G
V
A
V
-----
S
N
E
V
E
L
A
L
E
K
--
L
E
R
E
A
---------
K
T
A
V
I
V
A
R
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
-
I
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
I
F
-
G
------------
V
V
F
R
P
E
F
-----------
A
G
L
A
M
A
M
S
S
--
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.53
36%
-77
- C3 -
3J08
-
COPA_ARCFU
A:
[127-728]
--------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
L
I
-------
A
L
P
A
-
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
----
V
L
S
T
A
--
G
V
L
P
R
E
Y
S
--------
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
--
T
A
V
V
I
-
R
D
G
K
E
I
A
V
P
-
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
S
---
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
-------------
S
K
G
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
A
P
L
L
F
-----------
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
E
V
T
D
L
-
V
--------------------------------------
P
--
L
-
N
------------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
D
G
I
-------------
L
V
----------------
G
N
K
R
L
M
-----------------
E
D
F
G
V
-
A
---
V
--
S
----
N
E
V
E
--------
L
A
L
--
E
K
L
E
-----------
R
E
A
K
--
T
A
V
-
I
---------
V
A
R
-----
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
-
I
Y
N
V
I
L
I
P
A
A
A
G
L
L
Y
P
-
I
F
G
------------
V
V
F
R
P
E
F
-----------
A
G
L
A
M
A
M
S
S
--
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
P
P
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Fugue
74.14
27%
-70
- C3 -
4UMW
2
?
A:
[124-730]
-----------------
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
----
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
-
G
L
Y
P
I
---
A
R
Q
A
L
R
L
I
K
S
---
G
S
Y
F
A
--------------------------------------------------------------------------------------
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
---------------------------
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
V
----
S
A
L
M
A
L
K
P
E
--
T
A
T
R
L
-
R
N
G
E
R
E
E
V
A
-
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
A
---
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
-------------
A
T
G
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
-----
F
A
A
S
--
W
----
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
-----
P
-
R
V
T
A
-
I
--------------------------------------
H
P
A
T
-
G
------------------------
I
S
E
S
E
--
L
L
T
L
A
A
----------------
A
V
E
-----------------
Q
G
A
T
H
P
L
A
Q
A
I
V
R
E
--------------------
A
Q
V
A
E
L
A
I
P
T
A
E
S
Q
R
A
-------
L
V
G
S
G
I
E
A
Q
V
N
-------------------------------
G
E
R
V
L
I
-----------------
C
-----
A
---
A
--
G
KHPA
D
A
F
A
--------
G
L
I
--
N
E
L
E
-----
S
-----
A
G
Q
T
--
V
V
L
-
V
---------
V
R
------
N
D
D
------------------
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
-------------------------------
F
K
A
G
L
L
-----------------------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
P
-
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
-
G
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
-
G
L
K
G
I
F
L
V
T
T
L
----------------------
L
G
M
T
G
L
-----------
W
L
A
V
L
A
D
T
G
--
A
T
V
L
V
T
A
N
A
L
R
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.17
26%
-75
- C6 -
4UMW
2
?
A:
[124-697]
---------------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
-----------
L
E
Q
F
N
H
P
-
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
-
R
-
L
I
K
S
G
S
Y
F
A
I
E
----------
T
L
M
S
V
A
A
I
G
A
--------------
L
F
--
I
G
A
T
A
-------------
E
A
A
M
V
L
L
L
F
-
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
--
T
A
T
R
L
-
R
N
G
E
R
E
E
V
A
-
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
A
---
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
-------------
A
T
G
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
A
A
S
W
Q
E
W
I
--
Y
----
K
G
-----
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
-----
P
-
R
V
T
A
-
I
--------------------------------------
H
P
A
T
-
G
------------------------
I
S
E
S
E
--
L
L
T
L
A
A
----------------
A
V
E
-----------------
Q
G
A
T
H
P
L
A
Q
A
I
V
R
E
--------------------
A
Q
V
A
E
L
A
I
P
T
A
E
S
Q
R
A
-------
L
V
G
S
G
I
E
A
Q
V
N
-------------------------------
G
E
R
V
L
I
C
A
AG-------------
K
-----
H
---
P
--
A
----
D
A
F
A
--------
G
L
I
--
N
E
L
E
-----
S
-----
A
G
Q
T
--
V
V
L
-
V
---------
V
------
R
N
D
D
------------------
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------
E
--------------------------------
F
K
A
G
L
L
-----------------------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
P
L
A
-
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
-
G
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
-
G
L
K
G
I
F
L
V
T
T
L
L
G
M
T
G
-
L
-
W
------------
L
A
V
L
A
D
T
-----------
G
A
T
V
L
V
T
A
N
--
A
L
R
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.00
26%
-69
* C6 *
4UMV
2
?
A:
[126-697]
-----------------------------------------------------------------------------------------
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
-----------
L
E
Q
F
N
H
P
-
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
-
R
-
L
I
K
S
G
S
Y
F
A
I
E
----------
T
L
M
S
V
A
A
I
G
A
--------------
L
F
--
I
G
A
T
A
-------------
E
A
A
M
V
L
L
L
F
-
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
--
T
A
T
R
L
-
R
N
G
E
R
E
E
V
A
-
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
A
---
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
-------------
A
T
G
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
A
A
S
W
Q
E
W
I
--
Y
----
K
G
-----
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
-----
P
-
R
V
T
A
-
I
--------------------------------------
H
P
A
T
-
G
------------------------
I
S
E
S
E
--
L
L
T
L
A
A
----------------
A
V
E
-----------------
Q
G
A
T
H
P
L
A
Q
A
I
V
R
E
--------------------
A
Q
V
A
E
L
A
I
P
T
A
E
S
Q
R
A
-------
L
V
G
S
G
I
E
A
Q
V
N
-------------------------------
G
E
R
V
L
I
C
A
A
G-------------
K
-----
H
---
P
--
A
----
D
A
F
A
--------
G
L
I
--
N
E
L
E
-----
S
-----
A
G
Q
T
--
V
V
L
-
V
---------
V
------
R
N
D
D
------------------
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------
E
--------------------------------
F
K
A
G
L
L
-----------------------------
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
P
L
A
-
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
-
G
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
-
G
L
K
G
I
F
L
V
T
T
L
L
G
M
T
G
-
L
-
W
------------
L
A
V
L
A
D
T
-----------
G
A
T
V
L
V
T
A
N
--
A
L
R
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
64.11
20%
-60
- C3 -
3B8E
6
AT1A1_PIG
A:
[1-998]
-----------------------------
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
T
D
L
S
R
G
---
L
T
P
A
R
A
A
E
I
L
---
A
R
D
G
P
N
-------------------
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
R
Q
L
-
F
G
G
F
S
-
M
L
L
W
I
G
A
-------
I
L
------------------------------------------------
C
F
--
L
A
Y
G
I
Q
A
A
T
E
E
E
P
Q
N
D
N
L
Y
L
G
V
V
L
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A
V
V
I
I
T
G
C
F
S
Y
Y
Q
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A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
--
Q
A
L
V
I
-
R
N
G
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M
S
I
N
-
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
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I
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A
D
L
R
I
I
S
A
N
G
C
--
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
-------------
S
P
D
F
T
N
ENPLETRNI
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
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I
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H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
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------
Y
T
--
W
----
L
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A
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I
F
L
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G
I
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A
N
V
P
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G
L
L
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L
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A
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C
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L
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L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
-----
M
-
T
V
A
H
-
M
--------------------------------------
W
--
S
-
D
N
Q
I
H
E
A
DTTENQSGVSFDKTS
A
T
W
L
A
L
S
R
--
I
A
G
L
C
N
----------------
R
A
V
F
Q
A
NQENLPILK
R
A
V
A
G
D
A
S
E
S
A
L
L
K
C
I
E
L
C
CGS-----------------
V
K
E
M
R
E
R
Y
T
K
I
V
E
I
P
F
-------
N
S
T
N
K
Y
Q
L
S
I
H
K
N
PNTAEPR
H
L
L
V
M
K
----------------
G
A
P
E
R
I
L
D
R
CS
S
I
L
I
HGKEQPLD
E
-----
E
---
L
--
K
----
D
A
F
Q
--------
N
A
Y
--
L
E
L
G
-----
G
-----
L
G
E
R
--
V
L
G
-
F
---------
C
H
L
F
L
P
D
E
Q
F
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EGF
Q
F
D
T
DDVNFPLDN
L
C
F
V
G
L
I
S
M
I
D
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P
R
A
A
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D
A
V
G
K
C
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A
G
I
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P
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A
K
A
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A
K
G
V
G
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ISEGN
E
T
V
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D
IAARLNIPVSQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
MT
S
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Q
L
D
D
I
L
K
YHT
E
I
-------------------------------
V
F
A
R
T
S
-----------------------------
P
Q
Q
K
L
I
I
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G
C
Q
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Q
G
A
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A
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D
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D
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P
A
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K
K
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M
G
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A
G
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D
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S
K
Q
A
A
D
M
I
L
L
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F
A
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G
V
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G
R
L
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L
K
K
S
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A
Y
T
L
T
S
N
I
P
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I
T
P
F
L
I
F
I
I
A
N
-
I
-
P
------------
L
P
L
G
T
V
T
I
L
C
I
DLGTD
M
V
P
A
I
S
L
A
Y
E
Q
--
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
T
D
K
L
VN
E
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
106
Fugue
62.18
17%
-67
- C2 -
1SU4
3
AT2A1_RABIT
A:
[1-994]
M
E
A
A
H
----------------------------------------
S
K
S
T
E
E
C
L
A
Y
F
G
V
S
E
-
T
T
G
L
T
-----
P
D
Q
V
K
R
H
L
---
E
K
Y
G
H
N
E
------------------------------
L
P
A
E
E
G
-
K
S
L
W
E
-
L
V
I
E
Q
F
E
-------
D
L
-
L
-
V
R
I
L
L
L
A
A
C
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L
A
W
F
E
E
G
E
E
----------------------------------------
T
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L
L
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L
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A
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A
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A
L
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S
I
L
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S
V
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K
H
TEPVPDPRAVNQ
D
K
K
N
M
----------
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
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I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
D
P
V
H
G
G
S
--
W
I
R
G
A
I
Y
Y
F
K
I
A
V
A
L
A
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A
A
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P
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L
P
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I
T
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C
L
A
L
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R
R
M
A
K
K
N
A
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V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
-----
M
-
S
V
C
K
-
M
F
I
IDKVDGD
F
C
S
L
N
E
F
S
I
T
G
S
T
YAP
E
G
E
V
L
K
ND
K
P
I
R
S
G
--
Q
-
F
------------------------
D
G
L
V
E
--
L
A
T
I
C
A
L
CND
S
S
L
D
F
NETKG
V
Y
E
K
V
-----------------
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEVRNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
E
F
T
L
E
F
-------
S
R
D
R
K
S
M
S
V
Y
C
-------------
S
P
AKSSRAAVG
N
K
M
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K
G
A
P
E
G
V
I
D
R
CN
Y
V
R
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GT
T
R
V
P
MT-
G
-----
P
---
V
--
K
----
E
K
I
L
--------
S
V
I
--
K
E
W
G
-----
T
-----
G
R
D
T
L
R
C
L
A
-
L
---------
A
T
R
D
T
P
P
K
R
E
E
MVLDDSSR
F
M
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TD
L
T
-
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
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S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
-----------------------------------------------------
F
G
ENEEVADRAYT
G
R
E
F
D
D
LP
L
A
E
Q
R
E
A
C
R
R
AC
C
F
A
R
V
E
-----------------------------
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
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I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
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I
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I
A
M
-
G
S
G
T
A
V
A
K
T
A
S
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M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
-
S
S
N
V
G
E
V
V
C
I
F
L
T
A
A
L
-
G
-
L
PEALI
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
-----------
P
A
T
A
L
G
F
N
P
PD
L
D
I
M
D
R
P
P
R
S
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
MYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
LSENQSLMRMPPWVN
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
YV
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
YLEG----------------
8
PsiBlast_PDB
56.89
36%
-58
- C3 -
3SKX
2
A:
[5-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
-----
F
-
G
V
T
D
-
I
V
G
FN----------------------------------
H
--
S
-
E
------------------------
D
E
L
L
Q
--
I
---
A
A
----------------
S
L
E
-----------------
A
R
S
E
H
P
I
A
A
A
I
V
E
E
--------------------
A
E
K
R
G
F
G
L
T
E
V
E
E
F
R
A
-------
I
P
G
K
G
V
E
G
I
V
N
-------------------------------
G
R
R
Y
M
V
-----------------
V
-----
S
---
P
--
G
----
Y
I
R
E
--------
L
G
I
--
K
T
D
E
S
V
E
K
-
L
-----
K
Q
Q
G
K
-
T
V
V
-
F
---------
I
-----
L
K
N
G
E
------------------
V
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
-----------------------------------------------------
D
D
-------------------------------
Y
F
A
E
V
L
-----------------------------
P
H
E
K
A
E
K
V
K
E
V
Q
Q
K
-
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
-
G
A
G
T
D
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A
V
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T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
T
Y
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
55.87
22%
-50
- C3 -
1MHS
-
PMA1_NEUCR
A:
[144-682]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
V
I
C
G
L
L
L
L
N
A
V
V
G
F
V
Q
E
F
Q
A
G
S
I
V
D
E
L
K
---
K
T
L
A
L
--
K
A
V
V
L
-
R
D
G
T
L
K
E
I
E
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A
P
E
V
V
P
G
D
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L
Q
V
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G
T
I
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P
A
D
G
R
I
V
T
D
D
A
F
L
-
Q
V
D
Q
S
A
L
T
G
E
S
L
A
V
D
K
-------------
H
K
G
D
Q
----------
V
F
A
S
S
A
V
K
R
G
E
A
F
V
V
I
T
A
T
G
D
N
T
F
V
G
R
A
A
A
L
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N
A
A
S
G
G
S
G
H
F
T
E
V
L
N
G
I
G
T
I
L
---
L
I
L
V
I
F
T
L
L
I
V
W
V
-----
S
S
F
Y
R
S
NP
I
----
V
Q
I
L
E
F
T
L
A
I
T
I
I
G
V
P
V
G
L
P
A
V
V
T
T
T
M
A
V
G
A
A
Y
L
A
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K
K
A
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V
Q
K
L
S
A
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S
L
A
G
V
E
I
L
C
S
D
K
T
G
T
L
T
K
N
K
LSLHD
P
-
Y
T
V
A
-
G
--------------------------------------
V
--
D
-
P
------------------------
E
D
L
M
L
--
T
A
C
L
A
A
----------------
S
R
K
-----------------
K
K
G
I
D
A
I
D
K
A
F
L
K
S
--------------------
L
K
Y
Y
P
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A
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S
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L
S
K
Y
K
V
L
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FHPFD
P
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K
V
V
A
V
V
E
-------------
S
P
----------------
Q
G
E
R
I
T
-----------------
C
-----
V
---
K
--
G
----
A
P
L
F
V
L
K
TVEED
H
P
I
P
E
E
V
D
Q
-----
A
-----
Y
K
N
K
--
V
A
E
-
F
A
T
R
G
F
R
S
L
G
V
A
R
K
R
G
E
G
S
W
E
------------------
I
L
G
I
M
P
C
M
D
P
P
R
H
D
T
Y
K
T
V
C
E
A
K
T
L
G
L
S
I
K
M
L
T
G
D
A
V
G
I
A
R
E
T
S
R
Q
L
G
L
-----------------------------------------------------
G
T
-------------------------------
N
I
Y
N
A
E
RLGLGGGGDMPGSEV
Y
D
F
V
E
AADGF
A
E
V
F
P
Q
H
K
Y
N
V
V
E
I
L
Q
Q
R
G
Y
L
V
A
M
T
G
D
G
V
N
D
A
P
S
L
K
K
A
D
T
G
I
A
V
-
E
G
S
S
D
A
A
R
S
A
A
D
I
V
F
L
A
P
G
L
G
A
I
I
D
A
L
K
T
S
R
Q
I
F
H
R
M
Y
A
Y
V
V
Y
R
I
-
A
L
S
I
H
L
E
I
F
L
G
L
W
I
A
I
-
L
-
N
------------
R
S
L
N
I
E
L
-----------
V
V
F
I
A
I
F
A
D
--
V
A
T
L
A
I
A
Y
D
N
A
P
Y
S
Q
T
P
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
55.45
35%
-50
- C3 -
3A1E
2
COPA_ARCFU
A:
[14-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
-
E
V
T
D
L
V
--------------------------------------
P
--
L
-
N
------------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
Q
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
D
G
I
-------------
L
V
----------------
G
N
K
R
L
M
-----------------
E
D
F
G
V
A
V
---
S
--
N
-----
E
V
E
--------
L
A
L
--
E
K
L
E
-----------
R
E
A
K
--
T
A
V
-
I
---------
V
A
R
-----
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
55.44
35%
-50
- C3 -
2YJ6
2
?
B:
[13-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
-----
P
-
I
V
T
Q
F
I
--------------------------------------
G
--
D
-
S
------------------------
L
S
L
------
A
Y
A
A
----------------
S
V
E
-----------------
A
L
S
S
H
P
I
A
K
A
I
V
K
Y
--------------------
A
K
E
Q
G
V
K
I
L
E
V
K
D
F
K
E
-------
I
S
G
I
G
V
R
G
K
I
---------------------------------
S
D
K
I
I
-----------------
E
-----
V
---
K
--
K
----
A
E
------------------------------
N
N
N
D
--
I
A
V
-
Y
---------
I
N
-------
G
E
------------------
P
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
E
-------------------------------
Y
Y
S
N
L
S
-----------------------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
-
G
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
54.64
35%
-51
- C3 -
3A1C
1
?
B:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
-
E
V
T
D
L
V
--------------------------------------
P
--
L
-
N
------------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
D
G
I
-------------
L
V
----------------
G
N
K
R
L
M
-----------------
E
DFGVA
V
---
S
--
N
-----
E
V
E
--------
L
A
L
--
E
K
L
E
-----------
R
E
A
K
--
T
A
V
-
I
---------
V
A
R
-----
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
54.22
35%
-53
- C3 -
3A1D
2
?
B:
[13-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
-
E
V
T
D
L
V
--------------------------------------
P
--
L
-
N
------------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
D
G
I
-------------
L
V
----------------
G
N
K
R
L
M
-----------------
E
D
F
G
V
A
V
---
S
--
N
-----
E
V
E
--------
L
A
L
--
E
K
L
E
-----------
R
E
A
K
--
T
A
V
-
I
---------
V
A
R
-----
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.09
35%
-48
- C3 -
3A1C
2
?
A:
[14-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
-
E
V
T
D
L
V
--------------------------------------
P
--
L
-
N
------------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
D
G
I
-------------
L
V
----------------
G
N
K
R
L
M
-----------------
E
D
F
G
V
A
V
---
S
--
N
-----
E
V
E
--------
L
A
L
--
E
K
L
E
-----------
R
E
A
K
--
T
A
V
-
I
---------
V
A
R
-----
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
53.49
35%
-51
- C3 -
3A1E
1
B:
[13-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
-
E
V
T
D
L
V
--------------------------------------
P
--
L
-
N
------------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
Q
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
D
G
I
-------------
L
V
----------------
G
N
K
R
L
M
-----------------
E
D
F
G
V
A
V
---
S
--
N
-----
E
V
E
--------
L
A
L
--
E
K
L
E
-----------
R
E
A
K
--
T
A
V
-
I
---------
V
A
R
-----
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
53.29
35%
-48
- C3 -
2YJ5
1
?
B:
[13-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
-----
P
-
I
V
T
Q
F
I
--------------------------------------
G
--
D
-
S
------------------------
L
S
L
------
A
Y
A
A
----------------
S
V
E
-----------------
A
L
S
S
H
P
I
A
K
A
I
V
K
Y
--------------------
A
K
E
Q
G
V
K
I
L
E
V
K
D
F
K
E
-------
I
S
G
I
G
V
R
G
K
I
---------------------------------
S
D
K
I
I
-----------------
E
-----
V
---
K
--
K
----
A
E
------------------------------
N
N
N
D
--
I
A
V
-
Y
---------
I
N
-------
G
E
------------------
P
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
E
-------------------------------
Y
Y
S
N
L
S
-----------------------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
-
G
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
53.00
35%
-42
- C3 -
2YJ4
1
?
B:
[13-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
I
I
K
N
S
N
V
Y
E
K
I
K
E
I
D
T
I
I
F
N
K
T
G
T
L
T
Y
G
T
-----
P
-
I
V
T
Q
F
I
--------------------------------------
G
--
D
-
S
------------------------
L
S
L
------
A
Y
A
A
----------------
S
V
E
-----------------
A
L
S
S
H
P
I
A
K
A
I
V
K
Y
--------------------
A
K
E
Q
G
V
K
I
L
E
V
K
D
F
K
E
-------
I
S
G
I
G
V
R
G
K
I
---------------------------------
S
D
K
I
I
-----------------
E
-----
V
---
K
--
K
----
A
E
------------------------------
N
N
N
D
--
I
A
V
-
Y
---------
I
N
-------
G
E
------------------
P
I
A
S
F
N
I
S
D
V
P
R
P
N
L
K
D
Y
L
E
K
L
K
N
E
G
L
K
I
I
I
L
S
G
D
K
E
D
K
V
K
E
L
S
K
E
L
N
I
-----------------------------------------------------
Q
E
-------------------------------
Y
Y
S
N
L
S
-----------------------------
P
E
D
K
V
R
I
I
E
K
L
K
Q
N
G
N
K
V
L
M
I
G
D
G
V
N
D
A
A
A
L
A
L
A
D
V
S
V
A
M
-
G
N
G
V
D
I
S
K
N
V
A
D
I
I
L
V
S
N
D
I
G
T
L
L
G
L
I
K
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
52.43
34%
-38
* C3 *
3A1C
2
?
A:
[14-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
-----
P
-
E
V
T
D
-
L
--------------------------------------
V
--
P
-
L
N-----------------------
G
D
E
R
E
--
L
L
R
L
A
A
----------------
I
A
E
-----------------
R
R
S
E
H
P
I
A
E
A
I
V
K
K
--------------------
A
L
E
H
G
I
E
L
G
E
P
E
K
V
E
V
-------
I
A
G
E
G
V
V
A
-------------------------------------
D
G
I
-----------------
L
-----
V
---
G
--
N
----
K
R
L
M
--------
E
D
F
--
G
V
A
V
-----
S
N
E
V
E
L
A
L
E
K
--
L
E
R
E
A
---------
K
T
A
V
I
V
A
R
N
G
R
------------------
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
L
-------------------------------
V
I
A
E
V
L
-----------------------------
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
-
G
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------