@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0356: (2015-12-14 )
MKPTNEPKKPFFQSPIVLAVLGGILLIFFLRSFNSDGSFSDNFLASSTKNVSYHEIKQLISNNEVENVSIGQTLIKASHKEGNNRVIYIAKRVPDLTLVPLLDEKKINYSGFSESNFFTDMLGWLMPILVILGLWMFMANRMQKNMGGGIFGMGSAKKLINAEKPNVRFNDMAGNEEAKEEVVEIVDFLKYPERYANLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAHVPFFSMGGSSFIEMFVGLGASRVRDLFETAKKQAPSIIFIDEIDAIGKSRAAGGMISGNDEREQTLNQLLAEMDGFGSENAPVIVLAATNRPEILDPALMRPGRFDRQVLVDKPDFNGRVEILKVHIKGVKLANDVNLQEVAKLTAGLAGADLANIINEAALLAGRNNQKEVKQQHLKEAVERGIAGLEKKSRRISPKEKKIVAYHESGHAVISEMTKGSTRVNKVSIIPRGMAALGYTLNTPEENKYLMQKHELIAEIDVLLGGRAAEEVFLEEISTGASNDLERATDIIKGMVSYYGMSSVSGLMVLEKQRNAFLGGGYGSSREFSEKTAEEMDLFIKNLLEERYQHVKQTLSDYREAIEIMVKELFDKEVITGERVREIISEYEAANNLESRLIPLEEQAS
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180......-.-190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360-.....--...370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500-........510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKPTNEPKKPFFQS
P
I
V
L
A
V
L
G
G
I
L
L
I
F
F
L
R
S
FNSDGSFSDNFLASSTKNV
S
Y
H
E
I
K
Q
L
I
SNNEVEN
V
S
I
G
Q
T
L
I
K
ASHKEGNN
R
V
I
Y
I
AKRVPD
L
T
L
V
PLLDEKKINYSGFSES
N
F
F
T
D
M
L
G
W
L
M
P
I
L
V
I
L
G
L
W
M
F
M
A
N
R
M
Q
K
NMGGGIFGMG
S
A
K
K
L
INAEKPN
V
R
FNDMAG
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
-K
Y
P
E
R
Y
A
NLGAKIPK
G
V
L
L
VGPPGT
G
K
T
L
L
A
K
A
VAGEAHV
P
F
FSMG
G
S
S
F
I
E
M
F
V
GL
G
A
S
R
V
R
D
L
F
E
T
A
K
KQA
P
S
I
I
F
I
DE
I
D
AIGKSRAAGGMISGN
D
E
R
E
Q
T
L
N
Q
L
L
A
E
MDGFGSENA
P
V
I
V
L
AATNRPEIL
D
P
A
LMRPGRFD
R
Q
V
L
VDKPDFNG
R
V
E
I
L
K
V
H
I
K
G
V
K
LA--NDV
N
L
--
Q
E
V
A
K
L
T
AGLA
G
A
D
L
A
N
I
I
N
E
A
A
L
LAGRN
N
Q
K
E
V
K
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
K
SRRISPKE
K
K
I
V
A
Y
HES
G
H
A
V
I
S
E
MTKGSTR
V
N
K
V
S
I
IPR
G
M
A
AL
G
Y
TLNTPEE
N
K
Y
L
M
Q
K
H
E
L
I
A
E
I
D
V
L
LGG
R
A
A
E
E
V
F
L
--
E
E
I
STGASN
D
L
E
R
A
T
D
I
I
K
G
M
V
S
Y
Y
G
M
S
SVS
G
L
M
V
L
EKQR
N
A
F
LGGGYGSS
R
E
F
S
E
K
T
A
E
E
M
D
L
F
I
K
N
L
L
E
E
R
Y
Q
H
V
K
Q
T
L
S
D
Y
R
E
A
I
E
I
M
V
K
E
L
FDKEVI
T
G
E
R
V
R
E
I
I
S
E
Y
E
A
ANN
L
E
SRLIPLEEQAS
4
PsiBlast_PDB
91.46
54%
-93
- C1 -
4WW0
2
FTSH_AQUAE
A:
[11-461]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
-
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
------------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
S
D
G
-
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
-----------------
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
GK
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
R
--------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
K
K
--------
33
PsiBlast_CBE
91.09
54%
-92
- C1 -
4WW0
3
FTSH_AQUAE
C:
[11-461]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
-
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
----
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
S
D
G
-
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
---------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
---------------
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
GK
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
-------------
A
V
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
K
---------
27
PsiBlast_CBE
89.06
53%
-91
- C1 -
2CEA
2
FTSH_THEMA
C:
[13-458]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
-
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
--------------
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
K
E
G
-
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
--
G
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
--------------
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
----------------
26
PsiBlast_CBE
88.61
53%
-88
- C1 -
2CEA
1
FTSH_THEMA
D:
[13-458]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
-
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
-------------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
K
E
G
-
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
----
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
--------------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
--
G
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
-------------
L
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
----------------
29
PsiBlast_CBE
88.51
53%
-88
- C1 -
2CE7
1
FTSH_THEMA
D:
[13-458]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
-
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
-------------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
K
E
G
-
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
----
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
--------------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
--
G
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
-------------
L
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
----------------
5
PsiBlast_PDB
87.99
54%
-87
- C1 -
4Z8X
3
FTSH_AQUAE
A:
[11-461]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
-
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
S
D
G
-
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
GK
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
R
--------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
K
K
--------
101
Fugue
87.95
51%
-88
- C1 -
2CE7
1
FTSH_THEMA
A:
[5-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
P
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
-
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
----------
H
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
S
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
K
Y
L
V
-----------------
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
--
G
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
------------
A
W
G
K
L
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
-------------------
30
PsiBlast_CBE
87.69
53%
-90
- C1 -
2CE7
2
FTSH_THEMA
C:
[13-458]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
-
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
--------------
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
K
E
G
-
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
--
G
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
--------------
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
----------------
32
PsiBlast_CBE
87.54
54%
-87
- C1 -
4Z8X
2
FTSH_AQUAE
B:
[11-461]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
-
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
S
D
G
-
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
GK
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
R
--------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
K
K
--------
28
PsiBlast_CBE
87.32
53%
-89
- C1 -
2CE7
11
FTSH_THEMA
F:
[13-458]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
-
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
-----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
K
E
G
-
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
---------
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
----------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
--
G
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
--------------
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
-----------------
25
PsiBlast_CBE
87.08
53%
-91
- C1 -
2CEA
11
FTSH_THEMA
F:
[13-458]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
-
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
-----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
K
E
G
-
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
---------
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
----------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
--
G
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
--------------
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
-----------------
31
PsiBlast_CBE
87.06
54%
-86
- C1 -
4Z8X
3
FTSH_AQUAE
C:
[11-461]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
-
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
S
D
G
-
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
GK
D
G
I
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
R
--------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
L
K
D
K
C
----------
3
PsiBlast_PDB
85.27
52%
-82
- C1 -
3KDS
2
FTSH_THEMA
E:
[13-458]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
-
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
K
E
G
-
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
G
P
A
R
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
--
G
D
V
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
K
-----------
R
L
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
-------------------
35
PsiBlast_CBE
80.22
49%
-78
- C1 -
2DHR
1
FTSH_THET8
E:
[18-466]
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
-
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
-
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
D
T
A
-
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
-
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
-
G
G
Y
-
D
V
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
42
PsiBlast_CBE
79.83
49%
-77
- C1 -
4EIW
1
FTSH_THET8
C:
[27-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
-
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
-
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
D
T
A
-
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
-
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
-
G
G
Y
-
D
V
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
40
PsiBlast_CBE
79.75
49%
-77
- C1 -
4EIW
1
FTSH_THET8
E:
[27-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
-
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
-
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
D
T
A
-
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
-
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
-
G
G
Y
-
D
V
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
7
PsiBlast_PDB
79.59
49%
-77
- C1 -
4EIW
1
FTSH_THET8
A:
[27-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
-
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
-
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
D
T
A
-
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
-
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
-
G
G
Y
-
D
V
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
112
HHSearch
79.09
50%
-74
- C1 -
2DHR
1
FTSH_THET8
A:
[22-475]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
-
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
-
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
F
M
M
P
R
R
-
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
G
--
Y
D
V
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
6
PsiBlast_PDB
78.97
49%
-77
- C1 -
2DHR
1
FTSH_THET8
A:
[18-466]
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
-
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
-
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
D
T
A
-
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
-
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
-
G
G
Y
-
D
V
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
37
PsiBlast_CBE
78.82
49%
-78
- C1 -
2DHR
1
FTSH_THET8
C:
[18-466]
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
-
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
-
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
D
T
A
-
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
-
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
--
D
D
V
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
-
G
G
Y
-
D
V
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
------------
22
PsiBlast_CBE
77.40
98%
-102
- C1 -
2R65
1
FTSH_HELPY
D:
[1-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
-
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
----------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
75.51
98%
-98
- C1 -
2R65
1
FTSH_HELPY
B:
[1-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
-
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
----------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.76
98%
-92
- C1 -
2R65
1
FTSH_HELPY
A:
[1-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
-
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
----------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.41
98%
-93
- C1 -
2R65
1
FTSH_HELPY
E:
[1-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
-
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
----------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.57
98%
-86
- C1 -
2R65
1
FTSH_HELPY
C:
[1-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
-
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
----------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
65.08
63%
-85
- C1 -
1IY1
1
FTSH_THET8
A:
[12-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
-
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
----------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
D
T
A
-
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.25
50%
-86
- C1 -
3H4M
1
PAN_METJA
A:
[5-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
-
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
-
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
--
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
E
K
K
K
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
63.85
48%
-82
- C1 -
3H4M
1
PAN_METJA
A:
[10-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
-
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
-
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
--
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
E
K
K
K
V
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
63.47
50%
-84
- C1 -
3H4M
1
PAN_METJA
B:
[5-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
-
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
-
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
--
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
E
K
K
K
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
63.25
50%
-88
- C1 -
3H4M
1
PAN_METJA
C:
[5-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
-
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
-
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
--
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
E
K
K
K
V
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
62.52
57%
-89
- C1 -
2QZ4
1
A:
[2-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
F
K
D
V
A
G
M
H
E
A
K
L
E
V
R
E
F
V
D
Y
-
L
-
K
S
P
E
------
A
K
V
P
K
G
A
L
L
L
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
T
E
A
Q
V
P
F
L
A
M
A
G
A
E
F
V
E
V
I
G
G
L
G
A
A
R
V
R
S
L
F
K
E
A
R
A
R
A
P
C
I
V
Y
I
D
E
I
-------------------
E
Q
T
L
N
Q
L
L
V
E
M
D
G
M
G
T
-
T
D
H
V
I
V
L
A
S
T
N
R
A
D
I
L
D
G
A
L
M
R
P
G
R
L
D
R
H
V
F
I
D
L
P
T
L
Q
E
R
R
E
I
F
E
Q
H
L
K
S
L
K
L
T
QS
S
T
F
Y
S
--
Q
R
L
A
E
L
T
P
G
F
S
G
A
D
I
A
N
I
C
N
E
A
A
L
H
--------
V
H
T
L
N
F
E
Y
A
V
E
R
V
L
A
G
T
A
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.48
63%
-82
- C1 -
1IY0
1
FTSH_THET8
A:
[9-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
-
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
D
T
A
-
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.40
56%
-89
- C1 -
2QZ4
1
A:
[3-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
F
K
D
V
A
G
M
H
E
A
K
L
E
V
R
E
F
V
D
Y
-
L
-
K
S
P
E
------
A
K
V
P
K
G
A
L
L
L
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
T
E
A
Q
V
P
F
L
A
M
A
G
A
E
F
V
E
V
I
G
G
L
G
A
A
R
V
R
S
L
F
K
E
A
R
A
R
A
P
C
I
V
Y
I
D
E
I
-------------------
E
Q
T
L
N
Q
L
L
V
E
M
D
G
M
G
T
T
D
H
-
V
I
V
L
A
S
T
N
R
A
D
I
L
D
G
A
L
M
R
P
G
R
L
D
R
H
V
F
I
D
L
P
T
L
Q
E
R
R
E
I
F
E
Q
H
L
K
S
L
K
L
T
--
Q
S
S
T
F
Y
S
Q
R
L
A
E
L
T
P
G
F
S
G
A
D
I
A
N
I
C
N
E
A
A
L
H
--------
V
H
T
L
N
F
E
Y
A
V
E
R
V
L
A
G
T
A
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------