@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0373: (2015-12-14 )
MKQTTINHSVELVGIGLHKGVPVKLVLEPLEENQGIVFYRSDLGVKLPLKPENIVDTKMATVLGKDNARISTIEHLLSAVHAYGIDNLKISVDNEEIPIMDGSALTYCMLLDEAGIKELDAPKKVMEIKQAVEVREGDKFVKIEPDSQLSLNFTIDFNHPVIAKQAHHFVFSKTAYKEQVAKARTFGFLQEVNYLRSIGLAKGGSLNNCIVLDENSILNKEGLRCEKEFVCHKILDAMGDLMVLGMPVMGKYTSFSGSHKLNSMLVKAILADAKNYEVLIASDPAKEFALQKAFA
Atome Classification :
(67 SA)
.........10........20........30........40...--.....50........60..-......70........80........90........100.......110....---...120.......130.......140.......150.......160--.--......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKQTTINH
S
V
E
L
V
G
I
GLHKGV
P
V
K
L
V
LEPLEENQ
G
I
V
F
Y
RSDL
G
--
V
KLPLKPEN
I
V
D
T
K
M
A
T
V
L-GKDNA
R
I
S
T
I
E
H
L
L
S
A
V
H
AYGID
N
L
K
I
S
VDNEEIPIMDGS
A
L
T
Y
C
M
L
LDEAGI---KELDA
P
K
K
V
M
E
I
K
Q
A
V
E
VREG
D
K
F
V
K
IEPDS
Q
L
S
L
N
F
T
I
DFNHP
V
I
--
A
--
K
QAH
H
F
V
FS
K
T
A
Y
K
E
Q
V
A
K
A
R
T
F
G
F
L
Q
E
V
N
Y
L
R
SIGLAKGGSL
N
N
C
I
V
LDENSILNKEGL
R
C
E
K
E
F
V
C
H
K
I
L
D
A
MG
D
L
M
V
LGMPVMGKYTSFSGS
H
K
L
N
S
M
L
V
K
A
I
L
ADAKN
Y
E
V
L
I
ASD
P
A
K
E
F
A
L
Q
KAFA
42
PsiBlast_CBE
97.82
43%
-100
- C13 -
4MDT
3
?
C:
[2-292]
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
PP
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
---
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
DS---
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
-
14
PsiBlast_PDB
96.99
43%
-100
- C13 -
4MDT
3
?
A:
[2-292]
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
---
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
D
S
S
--
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
-
15
PsiBlast_PDB
96.97
43%
-101
- C13 -
4MQY
9
?
A:
[2-292]
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
---
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
DS
S
--
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
S
17
PsiBlast_PDB
96.69
43%
-100
- C13 -
4ISA
21
?
A:
[2-292]
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
---
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
DS
S
--
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
-
41
PsiBlast_CBE
96.49
43%
-99
- C13 -
4MDT
3
?
D:
[4-292]
--
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
PP
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
---
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
DS
S
--
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
-----
44
PsiBlast_CBE
96.36
43%
-100
- C13 -
4IS9
3
?
B:
[2-292]
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
PP
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
---
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
DS
S
--
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
--
16
PsiBlast_PDB
96.22
43%
-99
- C13 -
4IS9
3
?
A:
[2-292]
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
---
D
E
L
N
C
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
DS
S
--
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
-
43
PsiBlast_CBE
96.15
43%
-102
- C13 -
4MDT
3
?
B:
[2-292]
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
L
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
V
I
E
V
N
A
P
E
I
P
I
M
D
G
S
A
A
P
F
V
Y
L
L
L
D
A
G
I
---
D
E
L
N
S
A
K
K
F
V
R
I
K
E
T
V
R
V
E
D
G
D
K
W
A
E
F
K
P
Y
N
G
F
S
L
D
F
T
I
D
F
N
H
P
A
I
DS
S
--
N
Q
R
Y
A
M
N
F
S
A
D
A
F
M
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
Y
V
T
F
Q
D
D
A
E
L
P
L
A
F
K
A
P
-
45
PsiBlast_CBE
95.45
41%
-97
- C13 -
3NZK
2
?
B:
[7-297]
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
M
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
PP
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
I
I
E
V
N
A
P
E
V
P
I
M
D
G
S
A
S
P
F
V
Y
L
L
L
D
A
G
I
---
E
E
L
N
S
A
K
K
F
L
R
L
K
E
T
V
R
V
E
D
G
D
K
W
A
E
L
S
P
F
N
G
F
R
L
D
F
T
I
D
F
N
H
P
A
I
DS
S
--
T
Q
R
Y
R
L
D
F
S
A
D
S
F
V
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
F
V
T
F
Q
D
E
A
E
M
P
L
A
F
K
A
P
-
32
PsiBlast_CBE
94.76
44%
-100
- C13 -
4FW5
4
LPXC_PSEAE
C:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
34
PsiBlast_CBE
94.75
44%
-101
- C13 -
4FW4
3
LPXC_PSEAE
D:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
25
PsiBlast_CBE
94.66
44%
-99
- C13 -
4FW7
6
LPXC_PSEAE
D:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
24
PsiBlast_CBE
94.66
44%
-100
- C13 -
2VES
5
LPXC_PSEAE
B:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
------------
1
PsiBlast_PDB
94.60
44%
-98
- C13 -
2VES
5
LPXC_PSEAE
A:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
------
31
PsiBlast_CBE
94.57
44%
-98
- C13 -
4FW5
3
LPXC_PSEAE
D:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
39
PsiBlast_CBE
94.55
44%
-104
- C13 -
4FW3
2
LPXC_PSEAE
B:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
9
PsiBlast_PDB
94.50
44%
-103
- C13 -
4FW4
2
LPXC_PSEAE
A:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
26
PsiBlast_CBE
94.48
44%
-100
- C13 -
4FW7
3
LPXC_PSEAE
C:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
10
PsiBlast_PDB
94.48
44%
-105
- C13 -
4FW5
5
LPXC_PSEAE
A:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
21
PsiBlast_CBE
94.46
44%
-100
- C13 -
4OKG
2
LPXC_PSEAE
B:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
----------
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
23
PsiBlast_CBE
94.42
44%
-96
- C13 -
2VES
6
LPXC_PSEAE
C:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
36
PsiBlast_CBE
94.32
44%
-101
- C13 -
4FW4
4
LPXC_PSEAE
B:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
67
HHSearch
94.30
44%
-97
- C13 -
3UHM
4
LPXC_PSEAE
A:
[2-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
35
PsiBlast_CBE
94.26
44%
-99
- C13 -
4FW4
4
LPXC_PSEAE
C:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
4
PsiBlast_PDB
94.23
44%
-99
- C13 -
4LCF
15
LPXC_PSEAE
A:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
--
11
PsiBlast_PDB
94.18
44%
-102
- C13 -
4FW6
9
LPXC_PSEAE
A:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
18
PsiBlast_PDB
94.10
41%
-100
- C13 -
3NZK
3
?
A:
[7-297]
I
K
Q
R
T
L
K
R
I
V
Q
A
T
G
V
G
L
H
T
G
K
K
V
T
L
T
M
R
P
A
P
A
N
T
G
V
I
Y
R
R
T
D
L
N
P
P
V
D
F
P
A
D
A
K
S
V
R
D
T
M
L
C
T
C
L
V
N
E
H
D
V
R
I
S
T
V
E
H
L
N
A
A
L
A
G
L
G
I
D
N
I
I
I
E
V
N
A
P
E
V
P
I
M
D
G
S
A
S
P
F
V
Y
L
L
L
D
A
G
I
---
E
E
L
N
S
A
K
K
F
L
R
L
K
E
T
V
R
V
E
D
G
D
K
W
A
E
L
S
P
F
N
G
F
R
L
D
F
T
I
D
F
N
H
P
A
I
DS
S
--
T
Q
R
Y
R
L
D
F
S
A
D
S
F
V
R
Q
I
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
Q
S
R
G
L
C
L
G
G
S
F
D
C
A
I
V
V
D
D
Y
R
V
L
N
E
D
G
L
R
F
E
D
E
F
V
R
H
K
M
L
D
A
I
G
D
L
F
M
C
G
H
N
I
I
G
A
F
T
A
Y
K
S
G
H
A
L
N
N
K
L
L
Q
A
V
L
A
K
Q
E
A
W
E
F
V
T
F
Q
D
E
A
E
M
P
L
A
F
K
---
29
PsiBlast_CBE
94.00
44%
-99
- C13 -
4FW6
4
LPXC_PSEAE
C:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
30
PsiBlast_CBE
93.99
44%
-102
- C13 -
4FW6
9
LPXC_PSEAE
B:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
8
PsiBlast_PDB
93.99
44%
-103
- C13 -
4FW3
3
LPXC_PSEAE
A:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
13
PsiBlast_PDB
93.96
44%
-99
- C13 -
4J3D
3
LPXC_PSEAE
A:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
------------
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
---
38
PsiBlast_CBE
93.90
44%
-104
- C13 -
4FW3
2
LPXC_PSEAE
C:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
7
PsiBlast_PDB
93.90
44%
-102
- C13 -
4OKG
2
LPXC_PSEAE
A:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
33
PsiBlast_CBE
93.79
44%
-104
- C13 -
4FW5
6
LPXC_PSEAE
B:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
5
PsiBlast_PDB
93.75
44%
-99
- C13 -
4LCG
19
LPXC_PSEAE
A:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
----
3
PsiBlast_PDB
93.65
44%
-98
- C13 -
3UHM
4
LPXC_PSEAE
A:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
6
PsiBlast_PDB
93.58
44%
-99
- C13 -
4LCH
20
LPXC_PSEAE
A:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
----
40
PsiBlast_CBE
93.56
44%
-100
- C13 -
4J3D
3
LPXC_PSEAE
B:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
C
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
------------
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
----
27
PsiBlast_CBE
93.54
44%
-101
- C13 -
4FW7
11
LPXC_PSEAE
B:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
G
R
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
12
PsiBlast_PDB
93.50
44%
-102
- C13 -
4FW7
8
LPXC_PSEAE
A:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
P
V
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
22
PsiBlast_CBE
93.48
44%
-100
- C13 -
3U1Y
4
LPXC_PSEAE
B:
[2-288]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
37
PsiBlast_CBE
93.35
44%
-104
- C13 -
4FW3
3
LPXC_PSEAE
D:
[5-291]
I
K
Q
R
T
L
K
N
I
I
R
A
T
G
V
G
L
H
S
G
E
K
V
Y
L
T
L
K
P
A
P
V
D
T
G
I
V
F
S
R
T
D
L
D
PV
V
E
I
P
A
R
A
E
N
V
G
E
T
T
M
S
T
T
L
-
V
K
G
D
V
K
V
D
T
V
E
H
L
L
S
A
M
A
G
L
G
I
D
N
A
Y
V
E
L
S
A
S
E
V
P
I
M
D
G
S
A
G
P
F
V
F
L
I
Q
S
A
G
L
---
Q
E
Q
E
A
A
K
K
F
I
R
I
K
R
E
V
S
V
E
E
G
D
K
R
A
V
F
V
P
F
D
G
F
K
V
S
F
E
I
D
F
D
H
P
V
F
--
R
GR
T
Q
Q
A
S
V
D
F
S
S
T
S
F
V
K
E
V
S
R
A
R
T
F
G
F
M
R
D
I
E
Y
L
R
S
Q
N
L
A
L
G
G
S
V
E
N
A
I
V
V
D
E
N
R
V
L
N
E
D
G
L
R
Y
E
D
E
F
V
K
H
K
I
L
D
A
I
G
D
L
Y
L
L
G
N
S
L
I
G
E
F
R
G
F
K
S
G
H
A
L
N
N
Q
L
L
R
T
L
I
A
D
K
D
A
W
E
V
V
T
F
E
D
A
R
T
A
P
I
S
Y
M
R
P
-
77
Fugue
87.45
36%
-89
* C13 *
4OZE
7
LPXC_AQUAE
A:
[2-267]
G
L
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
-
N
I
---
L
N
Q
N
R
E
I
D
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
F
-
L
--
G
--
R
Q
K
F
T
F
V
E
G
N
---
E
E
E
I
V
L
A
R
T
F
C
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
55
PsiBlast_CBE
87.13
35%
-101
- C13 -
2J65
7
LPXC_AQUAE
B:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
65
PsiBlast_CBE
86.95
35%
-105
- C13 -
4OZE
6
LPXC_AQUAE
B:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
C
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
52
PsiBlast_CBE
86.95
35%
-104
- C13 -
3P76
4
LPXC_AQUAE
A:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
46
PsiBlast_CBE
86.94
35%
-100
- C13 -
1YHC
6
LPXC_AQUAE
B:
[3-266]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
56
PsiBlast_CBE
86.92
35%
-101
- C13 -
2J65
9
LPXC_AQUAE
A:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
47
PsiBlast_CBE
86.91
35%
-102
- C13 -
1YHC
10
LPXC_AQUAE
A:
[3-266]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
66
PsiBlast_CBE
86.85
35%
-102
- C13 -
4OZE
7
LPXC_AQUAE
A:
[4-267]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
C
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
53
PsiBlast_CBE
86.83
35%
-102
- C13 -
2O3Z
6
LPXC_AQUAE
B:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
59
PsiBlast_CBE
86.81
35%
-100
- C13 -
2IER
7
LPXC_AQUAE
B:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
54
PsiBlast_CBE
86.77
35%
-102
- C13 -
2O3Z
6
LPXC_AQUAE
A:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
20
PsiBlast_PDB
86.73
35%
-101
- C13 -
1YH8
6
LPXC_AQUAE
A:
[3-266]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
48
PsiBlast_CBE
86.71
35%
-101
- C13 -
1YH8
5
LPXC_AQUAE
B:
[3-266]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
60
PsiBlast_CBE
86.64
35%
-100
- C13 -
2IER
8
LPXC_AQUAE
A:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
50
PsiBlast_CBE
86.64
35%
-101
- C13 -
4U3D
5
LPXC_AQUAE
A:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
57
PsiBlast_CBE
86.49
35%
-98
- C13 -
2IES
2
LPXC_AQUAE
B:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
62
PsiBlast_CBE
86.44
35%
-102
- C13 -
2GO4
6
LPXC_AQUAE
A:
[4-263]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
19
PsiBlast_PDB
86.39
35%
-98
- C13 -
1P42
5
LPXC_AQUAE
A:
[3-267]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
64
PsiBlast_CBE
86.37
35%
-104
- C13 -
2GO3
8
LPXC_AQUAE
A:
[4-263]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
49
PsiBlast_CBE
86.33
35%
-97
- C13 -
1P42
4
LPXC_AQUAE
B:
[3-267]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
51
PsiBlast_CBE
86.11
35%
-101
- C13 -
4U3B
6
LPXC_AQUAE
A:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
61
PsiBlast_CBE
85.93
35%
-101
- C13 -
2GO4
3
LPXC_AQUAE
B:
[4-263]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
58
PsiBlast_CBE
85.80
35%
-97
- C13 -
2IES
2
LPXC_AQUAE
A:
[4-268]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
N
Q
N
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------
63
PsiBlast_CBE
85.53
35%
-101
- C13 -
2GO3
12
LPXC_AQUAE
B:
[4-263]
--
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
NQN
R
E
I
D
----
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
-
F
L
--
G
--
R
Q
K
F
T
F
V
---
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
----------------------
78
Fugue
84.45
34%
-88
- C13 -
1P42
5
LPXC_AQUAE
A:
[1-267]
G
L
E
K
T
V
K
E
K
L
S
F
E
G
V
G
I
H
T
G
E
Y
S
K
L
I
I
H
P
E
K
E
G
T
G
I
R
F
F
K
N
--
G
--
V
Y
I
P
A
R
H
E
F
V
V
H
T
N
H
S
T
D
L
-
G
F
K
G
Q
R
I
K
T
V
E
H
I
L
S
V
L
H
L
L
E
I
T
N
V
T
I
E
V
I
G
N
E
I
P
I
L
D
G
S
G
W
E
F
Y
E
A
I
R
K
N
I
L
---
N
Q
N
R
E
-
I
D
Y
F
V
V
E
E
P
I
I
V
E
D
E
G
R
L
I
K
A
E
P
S
D
T
L
E
V
T
Y
E
G
E
F
K
N
F
L
--------
G
R
Q
K
F
T
F
V
E
G
N
E
E
E
I
V
L
A
R
T
F
A
F
D
W
E
I
E
H
I
K
K
V
G
L
G
K
G
G
S
L
K
N
T
L
V
L
G
K
D
K
V
Y
N
P
E
G
L
R
Y
E
N
E
P
V
R
H
K
V
F
D
L
I
G
D
L
Y
L
L
G
S
P
V
K
G
K
F
Y
S
F
R
G
G
H
S
L
N
V
K
L
V
K
E
L
A
K
K
Q
K
---------------------