@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0380: (2015-12-14 )
MLISIAFLLVLCLLNYSSFRMLKSFLTLKKISRYAYLGFFILLSAGEATFVFYRNVMPSHLFVLTSACSFVSFIAFVFSLSFYGFSYSVEKIDFLPSRRKGLKNFLRIGFYLALLGYFWRGFYEGLARPKIKETPIYLDKLDKELKIILLTDMHVGSLLQKDFVNYIVEEVNQKEVDMVLIGGDLVDENIEKVKSFLLPLNNLKSTHGTFYVPGNHEYYHGIEPILSFLNTLDMTILGNECVHLGGINLCGVYDYFARKRQDFAPDIDKALKKRDSSKPTILLAHQPKQIRSLKESHSIDLVLSGHTHAGQIFPFSLLVKLAQTYLHGLYKHSGTTQIYVSSGAGYWGIPLRFLAPSEIAYLRLLPKNQA
Atome Classification :
(20 SA)
-----......-----------...10........20.....---...30.--------..-.....40........50...------.....60.-.......70..-......80.....------...90........100.......110......--...120.......130-........-----140--.-.......150.......--------160--------------------.---------........170.--.--.....180......-.190------.-------------------------....----...200.----------------.--..-..--.----210..-----------.....220...-----------------.---.--..-.-.-230---------------------...-.-----.-----..-..-----240-------.-.----------.------.------.--.--...250--........------------------.-------------260----.--------..-..-----....---270.-.--.-....---280....--.----------------..--290.------------------.-------------...-....300..---.....310..---.-..-..320........330-.-......--------.340.......350...--....360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----ML
I
S
I
A
-----------
F
L
L
V
L
C
LL
N
Y
S
S
F
R
M
L
K
S
F
L
---
T
L
K
K
I
S
--------
R
Y
-
A
Y
L
G
F
F
I
L
LSAG
E
A
T
F
V
F
YR------NVMP
S
H
L
F
-
V
L
T
S
A
C
S
F
V
S
F
-
I
A
F
V
F
S
L
S
FYG
F
S
------
Y
S
V
E
K
I
DFL
P
S
R
R
K
G
L
K
N
F
L
R
I
G
F
--
Y
L
A
L
L
G
--
Y
F
W
R
G
F
Y
E
G
LARPKI--KETP
I
Y
L
D
-----KL---D-KE
L
K
I
I
L
L
TD
M
H
V
G
S
L
L
--------
Q
----------------------
K
---------
D
F
V
N
Y
I
V
E
EVNQ--K--EV
D
M
V
L
IG
G
D
L
V
D
E
-
N
I
-
E
------
K
-------------------------
V
K
S
F
----
L
L
P
L
NNL----------------K--ST-HG--
T
----
F
Y
VPG-----------NH
E
Y
YH--
G
I
E
-----------------
P
---
I
--
L
S
-
F
-
L
-
N
-----------------------TLD-
M
-----
T
-----
I
L-GN-----E---------
C
-
V
----------H------L------G--G--I
N
L
C
----
G
V
Y
D
Y
F
A
R
------------------
K
-------------
R
------Q--------DF-AP-----
D
I
D
K
---
A
L
K
K-R--D-SSK
P
---
T
I
L
L
AHQ--
P
----------------
K
Q
--
I
--
R
------------------
S
-------------
L
K
E-SH
S
I
D
L
V
LS---GHTHAGQI
F
P
---
F
-
S
L
-
L
V
K
L
-
A
Q
T
Y
L
H
G
L
Y
K--H-SG
T
T
Q
I
--------
Y
VSSGAGYWG
I
P
L
R
F
LA--PS
E
I
A
Y
L
R
LLPKNQA
50
Fugue
81.49
17%
-114
- C2 -
4J1Q
1
A:
[20-445]
H
M
E
R
L
M
L
E
P
V
W
EKQNEELSYT
E
H
I
I
V
L
F
E
T
E
R
S
V
T
D
S
I
A
S
H
M
KD
A
R
V
I
T
L
N
EAVGH
I
A
E
R
Y
Q
C
Y
M
Q
N
I
F
E
L
L
Q
S
K
V
R
K
L
S
A
G
------
R
I
I
I
Q
A
I
V
-
P
L
E
K
E
K
Q
L
F
A
G
-
V
S
G
L
F
K
T
A
E
I
E
F
S
K
L
T
A
Q
V
I
E
I
E
K
P
E
E
M
I
D
L
H
L
K
L
K
D
D
S
R
R
P
F
DK
Q
I
R
Y
E
A
G
Y
R
F
V
K
G
W
R
E
M
V
D
T
L
H
M
PW
R
D
E
G
V
Y
L
I
TGGAG
S
L
---
G
-
L
L
F
A
K
E
I
A
N
R
T
G
R
S
T
I
V
--------
L
T
G
RSVL----------------
S
---------
E
D
K
E
N
E
L
E
A
L
R
S
--
I
--
G
A
E
V
V
Y
R
E
A
D
V
S
D
Q
----
H
------
A
-------------------------
V
R
H
L
----
L
E
E
I
K
E
R
----------------
Y
--
G
T
L
N
G
--
I
----
I
H
G
A
G
S
S
K
D
R
F
IIHKT
N
E
E
F
Q
E
--
V
L
Q
-----------------
P
---
K
--
V
S
-
G
-
L
-
L
-----------------------
H
V
D
-
E
-----
C
-----
S
K
-
D
F
-----
P
LD
F
------
F
-
I
----------
F
------
F
------
S
--
S
--
V
S
G
C
LGNA
G
Q
A
D
Y
A
A
A
---------------------------------------
N
--------
S
F
-
M
D
-----
A
F
A
E
---
Y
R
R
S
-
L
--
A
-
A
S
K
K
R
F
G
S
T
I
S
F
N
W
--
P
----------------
L
---------------------------------------
W
E
E
-
G
G
M
----
Q
V
---
G
A
E
D
E
K
R
M
L
K
---
T
-
T
G
-
M
V
P
M
P
T
D
S
G
L
K
A
F
Y
Q
G
I
V
-
S
D
K
P
Q
V
--------
F
V
M
E
G
-------------------
Q
L
Q
K
M
K
Q
K
L
L
25
HHSearch
80.65
20%
-106
- C2 -
3D03
2
?
A:
[1-203]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
L
A
H
I
S
D
T
H
F
R
S
R
G
--------
E
----------------------
K
LYGFID
V
N
-
A
A
N
A
D
V
V
S
Q
L
N
A
--
L
RE
R
P
D
A
V
V
V
S
G
D
I
V
N
C
-
G
R
-
P
E
-----
E
-------------------------
Y
Q
V
A
----
R
Q
I
L
G
S
L
--------------------
N
-
Y
P
--
L
----
Y
L
I
P
G
-----------
N
H
D
D
K
A
--
L
F
L
-----------------
E
---
Y
--
L
Q
-
P
-
L
-
C
P----------------------
Q
L
G
-
S
-----
D
-----
A
--
N
N
-----
M
---------
R
-
C
----------
A
------
V
DD----
F
--
A
--
T
R
L
L
----
F
I
D
S
S
R
A
G
TS
K
G
W
-------------
L
-------------
T
------
D
--------
E
T
-
I
S
-----
W
L
E
A
---
Q
L
F
E
-
G
----
G
D
K
P
---
A
T
I
F
M
H
H
--
P
----------------
P
L
--
P
--
L
GNAQMDPIACENG
H
R
L
L
-
A
-------------
L
V
E
R
F
P
S
L
T
R
I
F
C
---
G
H
N
H
S
L
T
M
T
Q
---
Y
-
R
Q
-
A
L
I
S
-
T
L
P
G
T
V
H
Q
V
P
--
Y
-
C
H
A
D
T
D
--------
P
Y
Y
D
L
S
P
A
S
C
L
M
H
R
Q
V
G
--
E
Q
W
V
S
Y
Q
H
S
L
A
H
Y
A
G
36
HHSearch
75.63
26%
-87
- C2 -
3T1I
9
MRE11_HUMAN
A:
[30-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
N
T
F
K
I
L
V
A
T
D
I
H
L
G
F
M
E
--------
K
DAVRGN
D
T
--------------
F
---------
V
T
L
D
E
I
L
R
L
A
Q
E
--
N
--
E
V
D
F
I
L
L
G
G
D
L
F
H
E
-
N
K
-
P
------
S
R
K
T
----------------------
L
H
T
C
----
L
E
L
L
R
K
Y
CMGDRPVQFEILSDQL
N
--
I
S
-
I
P
--
V
----
F
S
I
H
G
-----------
N
H
D
D
P
T
--
G
A
D
-----------------
A
LC-
A
--
L
D
-
I
-
L
-
S
-----------------------
C
A
G
-
F
V
----
N
-----
H
F
-
G
R
-----
S
MSVE
K
I
D
I
S
P
-
V
----------
L
------
L
Q
K
----
G
ST
K
--
I
A
L
Y
----
G
L
G
S
I
P
D
E
------------------
R
-------------
L
Y
R
M
F
V
-
N
--------
K
K
-
V
T
-----
M
L
R
P
---
K
E
---
D
--
E
-
N
S
W
F
---
N
L
F
V
I
H
Q
--
N
----------------
R
S
--
K
--
H
GSTNFIPE----------
Q
-------------
F
L
D
--
D
F
I
D
L
V
I
W
---
G
H
E
H
E
C
K
I
A
P
---
T
-
K
N
-
E
Q
Q
L
-
F
Y
I
S
Q
P
G
S
S
V
--
V
-
T
S
L
S
P
G
--------
E
A
V
K
K
H
V
G
L
L
R
I
K
G
R
K
M
--
N
M
H
K
I
P
L
H
T
V
R
Q
F
F
M
28
HHSearch
73.65
17%
-88
* C2 *
2XMO
4
?
A:
[37-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
R
N
L
S
M
V
V
T
T
D
V
H
Y
F
A
P
S
--------
L
TDNG
K
A
F
E
K
Y
V
A
A
GDGKQLAY
S
D
---------
E
I
T
D
A
F
L
A
D
V
E
S
--
K
--
K
T
D
V
L
I
I
S
G
D
L
T
N
N
-
G
E
-
K
T
-----
S
-------------------------
H
E
E
L
----
A
K
K
L
T
Q
V
----------------
E
K
-
N
G
-
T
Q
--
V
----
F
V
V
P
G
-----------
N
H
D
I
N
N
--
P
W
A
R
K
F
E
KD
K
Q
L
P
T
D
T
I
S
P
T
D
---
F
--
S
K
-
I
-
Y
-
S
-----------------------
D
F
G
-
Y
-----
E
D----
A
I
-
S
S
DEFSL
S
---------
Y
-
L
----------
A
------
A
PS----
S
--
K
--
V
W
L
L
----
M
L
D
T
A
I
Y
K
------------------
T
NMQQGNPTT
E
G
G
L
T
------
A
--------
G
T
-
L
D
-----
W
I
K
E
---
S
S
A
L
-
A
--
K
K
N
G
A
K
---
L
I
P
V
L
H
H
--
N
----------------
L
T
--
D
--
H
NDVKGYTINY
N
Q
Q
V
I
---
D
-------------
A
L
T
-
E
G
A
M
D
F
S
L
S
---
G
H
I
H
T
Q
N
I
R
S
---
A
-
K
S
-
T
D
G
K
-
E
I
T
D
I
V
T
N
A
L
--
S
-
V
F
P
H
K
Y
--------
G
N
I
T
Y
S
A
K
N
K
N
F
T
Y
Q
S
Q
--
K
L
D
M
E
A
W
A
K
A
Q
G
S
T
D
33
HHSearch
72.19
21%
-109
- C2 -
1II7
6
MRE11_PYRFU
A:
[1-215]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
F
A
H
L
A
D
I
H
L
G
Y
E
Q
--------
F
HK
P
Q
R
E
E
E
F
-------------
A
---------
E
A
F
K
N
A
L
E
I
A
V
Q
--
E
--
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
R
-
P
S
P
G
---
T
-------------------------
L
K
K
A
----
I
A
L
L
Q
I
P
----------------
K
E
-
H
S
-
I
P
--
V
----
F
A
I
E
G
-----------
N
H
D
R
T
Q
--
R
G
P
-----------------
S
---
V
--
L
N
-
L
-
L
-
E
-----------------------
D
F
G
L
V
-----
Y
-----
V
I
-
G
M
-----
R
K
E
K
V
E
N
E--
Y
-
L
T
S
E
R
L
GNG
E
Y
L
------
V
K
G
V
Y
--
K
--
D
--
L
E
I
H
----
G
M
K
Y
M
S
-----------------------------------------------------
S
A
-----
W
F
E
A
N
KE
I
L
K
R
L
F
--
R
-
P
T
D
N
---
A
I
L
M
L
H
Q
--
G
----------------
V
R
--
E
--
V
------------------
S
E
A
R
GEDYFEIGLG
D
L
P
--
E
G
Y
L
Y
Y
A
L
---
G
H
I
H
K
R
Y
E
T
S
---
Y
-
S
G
-
S
P
V
V
-
Y
P
G
S
L
E
R
W
D
F
--
G
-
D
Y
E
V
R
Y
--------
E
W
D
G
I
K
F
K
E
R
Y
G
V
N
K
G
F
--
Y
I
V
E
D
F
K
P
R
F
V
E
I
K
V
45
Fugue
71.51
15%
-94
- C2 -
2HY1
3
CPDA_MYCTU
A:
[12-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
---
R
-
P
D
Y
V
L
L
H
I
S
D
T
H
L
I
D
----------
A
----------------------
D
---------
D
R
L
G
E
L
L
E
Q
L
N
Q
S
G
L
--
R
P
D
A
I
V
F
T
G
D
L
A
D
K
G
E
P
-
A
------
A
-------------------------
Y
R
K
L
----
R
G
L
V
E
P
F
----------------
A
--
A
Q
-
L
G
A
E
L
----
V
W
V
M
G
-----------
N
H
D
D
R
A
--
E
L
R
-----------------
K
---
F
--
L
L
-
D
-
E
-
A
-----------------------
P
S
M
-
A
-----
P
-----
L
---
D
-----
R
---------
V
-
C
----------
M
------
I
------
D
--
G
--
L
R
I
I
----
V
L
D
T
S
V
P
G
------------------
H
H
H
G
E
I
--------
R
------
A
--------
S
Q
-
L
G
-----
W
L
A
E
---
E
L
A
T
-
P
--
A
-
P
D
G
T
---
I
L
A
L
H
H
P
--
P
IPSVL
D
M
A
V
T
V
ELRD
Q
A
A
--
L
--
G
------------------
R
-------------
V
L
R
-
G
T
D
V
R
A
I
L
A
---
G
H
L
H
Y
S
T
N
A
T
F
VG
I
-
P
V
-
S
V
A
S
-
A
T
C
G
C
N
L
V
H
V
--
Y
-
P
D
T
V
V
H
--------
S
V
I
P
------------------------------
32
HHSearch
70.99
19%
-83
- C2 -
3THO
6
RAD50_THEMA
B:
[1-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
L
H
T
S
D
W
H
L
G
V
T
S
--------
W
TSSRPVDR
R
E
E
L
----------
K
---------
K
A
L
D
K
V
V
E
E
A
E
K
--
R
--
E
V
D
L
I
L
L
T
G
D
L
L
H
S
-
R
N
N
P
S
V
V
---
A
-------------------------
L
H
D
L
----
L
D
Y
L
K
R
M
----------------
M
--
R
T
-
A
P
--
V
----
V
V
L
P
G
-----------
N
Q
D
W
K
G
--
L
K
------------------
L
---
F
--
G
N
-
F
-
V
-
T
S
I
---------------------
S
S
D
-
I
-----
T
-----
F
V
M
S
F
-----
E
---------
P
-
V
----------
D
------
V
E
A
KR--
G
Q
-
K
--
V
R
I
L
----
P
F
P
Y
P
D
E
S
----------------------------------------K
N
E
G
D
F
R
F
F
L
-
E
S
-----
R
L
N
K
---
L
Y
E
E
A
L
--
K
-
K
E
D
F
---
A
I
F
M
G
H
F
--
T
----------------
V
E
--
G
--
L
------------------
A
GREIIINR-----
A
L
I
-
P
S
V
V
D
Y
A
A
L
---
G
H
I
H
S
F
R
E
I
Q
---
K
Q
P
L
-
T
I
Y
P
-
G
S
L
I
R
I
D
F
G
E
--
E
A
D
E
K
G
A
V
--------
F
V
E
L
K
R
G
E
P
P
R
Y
E
R
I
D
A
--
S
P
L
P
L
K
T
L
Y
Y
K
K
I
D
T
37
HHSearch
69.28
18%
-75
- C2 -
2QFP
11
PPAF_PHAVU
A:
[106-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
I
T
P
-----
P
Q
TGL
D
-
V
P
Y
T
F
G
L
I
G
D
L
G
Q
S
F
D
S
--------
N
--------------------------------
T
T
L
S
H
Y
--
E
L
S
P
--
K
--
K
G
Q
T
V
L
F
V
G
D
L
S
Y
A
-
D
R
-
Y
PNHDN
V
R
-------------------------
W
D
T
W
----
G
R
F
T
E
R
S
----------------
V
--
A
Y
-
Q
P
--
W
----
I
W
T
A
G
-----------
N
H
E
I
E
F
--
A
P
E
INETE------------
P
---
F
--
K
P
-
F
-
S
-
Y
-----------------------
R
Y
H
-
V
-----
P
YEASQ
S
T
-
S
P
-----
F
---------
W
-
Y
----------
S
------
I
K
R
----
A
--
S
--
A
H
I
I
----
V
L
S
S
Y
S
A
Y
G-----------------
R
-------------
G
------
T
--------
P
Q
-
Y
T
-----
W
L
K
K
---
E
L
R
K
-
V
KR
S
-
E
T
P
W
---
L
I
V
L
M
H
S
--
P
----------------
L
Y
--
N
--
S
YNHHFMEG
E
A
M
R
T
K
F
E
--
A
-------------
W
F
V
-
K
Y
K
V
D
V
V
F
A
---
G
H
V
H
A
Y
E
R
S
E
---
R
V
S
N
-
I
A
Y
K
-
I
T
N
G
L
C
T
P
V
K
----
D
Q
S
A
P
V
--------
Y
I
T
I
G
D
A
G
N
Y
G
V
I
D
S
N
M
--
I
Q
P
Q
P
E
Y
S
A
F
R
E
A
S
F
29
HHSearch
68.74
19%
-87
- C2 -
1UF3
3
?
A:
[4-194]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
R
Y
I
L
A
T
S
N
P
M
G
D
L
-------------------------------------------
E
A
L
E
K
F
V
K
L
A
P
D
--
T
--
G
A
D
A
I
A
L
I
G
N
L
M
P
K
-
A
A
-
K
S
R
----
D
-------------------------
Y
A
A
F
----
F
R
I
L
S
E
A
--------------------
H
-
L
P
--
T
----
A
Y
V
P
G
-----------
P
Q
D
A
P
I
--
W
-
E
-----------------
Y
---
L
--
R
E
-
A
-
A
-
N
V
E
L
V-------------------
H
P
E
-
M
-----
R
-----
N
V
-
H
E
-----
T
---------
F
T
F
----------
W
------
R
------
G
--
P
--
Y
L
V
A
----
G
V
G
G
E
I
A
D
------------------
E
-------------
G
E
P
E
E
HE
A
--------
L
R
Y
P
A
W
V
A
E
Y
R
L
K
A
---
L
W
E
L
----
K
--
D
Y
P
---
K
I
F
L
F
H
T
--
M
----------------
P
Y
--
H
--
K
GLNEQGS
H
E
V
A
-------
H
-------------
L
I
K
-
T
H
N
P
L
L
V
L
V
A
G
K
G
Q
K
H
E
M
L
G
A
S
---
W
-
V
V
-
V
P
G
D
-
L
S
E
G
E
Y
S
L
L
D
--
L
-
R
A
R
K
L
E
--------
T
G
N
V
R
-----------------------------
26
HHSearch
68.47
20%
-104
- C2 -
3AV0
3
MRE11_METJA
A:
[18-213]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
H
M
M
F
V
H
I
A
D
N
H
L
G
Y
R
Q
--------
Y
----------------------
N
L
D
D
R
E
K
D
I
Y
D
S
F
K
L
C
I
K
K
I
L
E
--
I
--
K
P
D
V
V
L
H
S
G
D
L
F
N
D
-
L
R
-
P
P
V
K
---
A
-------------------------
L
R
I
A
----
M
Q
A
F
K
K
L
----------------
H
E
-
N
N
-
I
K
--
V
----
Y
I
V
A
G
-----------
N
H
E
M
P
R
--
R
L
G
EE---------------
S
---
P
--
L
A
-
L
-
L
-
K
-----------------------
D
-
Y
-
V
-----
K
-----
I
L
-
D
G
-----
K
---------
D
V
I
----------
N
------
V
N-----
G
E
-
E
--
I
F
I
C
----
G
T
Y
Y
H
K
K
S
------------------
K
-------------
R
------
E
--------
E
M
-
L
D
-----
K
L
K
N
---
F
E
S
E
-
A
--
K
-
N
Y
K
K
---
K
I
L
M
L
H
Q
--
G
----------------
I
N
--
P
--
Y
IPLDYEL-----------
E
-------------
H
F
D
-
L
P
K
F
S
Y
Y
A
L
---
G
H
I
H
K
R
I
L
E
R
---
F
-
N
D
-
G
I
L
A
-
Y
S
G
S
T
E
I
I
Y
R
--
N
-
E
Y
E
D
Y
K
--------
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
D
L
D
--
I
S
D
I
E
K
I
D
I
E
C
R
E
F
V
24
HHSearch
67.35
17%
-85
- C2 -
3IB7
7
CPDA_MYCTU
A:
[16-226]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
A
A
-----
E
H
P--
R
-
P
D
Y
V
L
L
H
I
S
D
T
H
L
I
G
G
D
RRLYGAVD
A
----------------------
D
---------
D
R
L
G
E
L
L
E
Q
L
N
Q
S
G
L
--
R
P
D
A
I
V
F
T
G
D
L
A
D
K
-
G
E
-
P
A
-----
A
-------------------------
Y
R
K
L
----
R
G
L
V
E
P
F
----------------
A
A
Q
L
G
-
A
E
--
L
----
V
W
V
M
G
-----------
N
H
D
D
R
A
--
E
L
R
-------------------------
K
-
F
-
L
-
L
-----------------------
D
E
A
-
P
-----
S
------
M
-
A
P
-----
L
---------
D
-
R
V
C
--------
M
------
I
------
D
--
G
--
L
R
I
I
----
V
L
D
T
S
V
P
G
------------------
H
H
H
G
E
I
--------
R
------
A
--------
S
Q
-
L
G
-----
W
L
A
E
---
E
L
A
T
-
P
--
A
--
P
D
G
---
T
I
L
A
L
H
H
--
P
----------------
P
I
--
P
--
S
VLDMAVTVELRD
Q
A
A
L
G
-
R
-------------
V
L
R
-
G
T
D
V
R
A
I
L
A
---
G
H
L
H
Y
S
T
N
A
T
---
F
-
V
G
-
I
P
V
S
-
V
A
S
A
T
C
Y
T
Q
D
--
L
-
T
V
A
A
G
G
--------
T
R
G
R
D
G
A
Q
G
C
N
L
V
H
V
Y
P
--
D
T
V
V
H
S
V
I
P
L
G
G
G
E
T
38
HHSearch
65.85
16%
-76
- C2 -
1XZW
7
PPAF1_IPOBA
A:
[114-363]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
V
T
P
-----
P
K
PGP
D
-
V
P
Y
V
F
G
L
I
G
D
I
G
Q
T
H
D
S
--------
N
--------------------------------
T
T
L
T
H
Y
E
Q
--
N
S
--
A
--
K
G
Q
A
V
L
F
M
G
D
L
S
Y
S
-
N
R
-
W
PNHDN
N
R
-------------------------
W
D
T
W
----
G
R
F
S
E
R
S
----------------
V
--
A
Y
-
Q
P
--
W
----
I
W
T
A
G
-----------
N
H
E
I
D
Y
--
A
P
D
IGEYQ------------
P
---
F
--
V
P
-
F
-
T
-
N
-----------------------
R
Y
P
-
T
PHEAS
G
-----
S
G
-
D
P
-----
L
---------
W
-
Y
----------
A
------
I
K
R
----
A
--
S
--
A
H
I
I
----
V
L
S
S
Y
S
G
F
V-----------------
K
-------------
Y
------
S
--------
P
Q
-
Y
K
-----
W
F
T
S
---
E
L
E
K
-
V
NR
S
-
E
T
P
W
---
L
I
V
L
V
H
A
--
P
----------------
L
Y
--
N
--
S
YEAHYMEG
E
A
M
R
A
I
F
E
--
P
-------------
Y
F
V
-
Y
Y
K
V
D
I
V
F
S
---
G
H
V
H
S
Y
E
R
S
E
---
R
-
V
S
N
V
A
Y
N
-
I
V
N
A
K
C
T
P
V
S
----
D
E
S
A
P
V
--------
Y
I
T
I
G
D
G
G
N
S
E
G
L
A
S
E
M
--
T
Q
P
Q
P
S
Y
S
A
F
R
E
A
S
F
8
PsiBlast_PDB
64.41
24%
-55
- C2 -
4TUG
2
MRE11_METJA
C:
[46-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
L
H
S
G
D
L
F
N
D
-
L
R
-
P
------
P
-------------------------
V
K
A
L
----
R
I
A
M
Q
A
F
----------------
K
--
K
L
-
H
E
--
N
N
I
K
V
Y
I
V
A
G
-----------
N
H
E
M
P
R
RL
G
E
E
-----------------
S
---
P
--
L
A
-
L
-
L
-
K
-----------------------
D
Y
V
-
K
-----
I
-----
L
D
-
G
K
-----
D
---------
V
-
I
----------
N
------
V
------
N
--
G
E
E
I
F
I
C
----
G
T
Y
Y
H
K
K
S
------------------
K
-------------
R
------
E
--------
E
M
-
L
D
-----
K
L
K
N
---
F
E
S
E
-
A
--
K
-
N
Y
K
K
---
K
I
L
M
L
H
Q
--
G
----------------
I
N
PY
I
--
P
------------------
L
-------------
D
Y
E
-
L
E
H
F
D
L
P
K
F
---
S
Y
Y
A
L
G
H
I
H
K
----------
R
I
-
L
E
R
F
N
D
G
I
L
A
--
Y
-
S
G
S
T
E
I
IYRNE
Y
E
D
Y
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
D
--
L
D
I
S
D
I
E
K
I
D
I
E
C
R
E
30
HHSearch
63.23
12%
-44
- C2 -
2YVT
-
?
A:
[4-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
R
K
V
L
A
I
K
N
F
K
E
R
F
D
-------------------------------------------
L
L
P
K
L
K
G
V
I
A
E
--
K
--
Q
P
D
I
L
V
V
V
G
N
I
L
K
N
-
E
A
-
L
------
E
K
E
Y
E
R
A
H
L
A
RREPNR
K
V
I
H
E
N
E
H
Y
I
I
E
T
L
----
D
K
F
F
R
E
I
----------------
G
E
-
L
G
-
V
K
--
T
----
F
V
V
P
G
-----------
K
N
D
A
P
L
--
K
I
F
-----------------
L
---
R
--
A
A
-
Y
E
A
E
T
A----------------------
Y
P
N
-
I
-----
R
-----
V
L
-
H
E
-----
G
---------
F
-
A
G
---------
W
------
R
------
G
--
E
--
F
E
V
I
----
G
F
G
G
L
L
T
E
------------------
H
E
------------
F
E
-----
E
DF
V
L
K
Y
P
R
W
Y
-
V
E
-----
Y
I
L
K
---
F
V
N
E
-
L
----
K
P
R
R
---
L
V
T
I
F
Y
T
--
P
----------------
P
I
--
G
--
E
FVDRTPEDPKHHGS
A
V
V
N
T
-------------
I
I
K
-
S
L
N
P
E
V
A
I
V
---
G
H
V
G
K
G
H
E
L
V
---
G
-
N
T
-
I
V
V
N
-
P
G
E
F
E
E
G
R
Y
A
--
F
-
L
D
L
T
Q
H
--------
K
I
K
L
E
Q
F
S
--------------------------
34
HHSearch
63.15
18%
-88
- C2 -
3RL5
4
MPPD2_RAT
A:
[57-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
G
H
T
R
F
V
C
I
S
D
T
R
S
R
T
D
G
--------------------------------------------------
I
Q
M
--
P
--
Y
G
D
I
L
L
H
T
G
D
F
T
E
L
-
G
L
-
P
S
-----
E
-------------------------
V
K
K
F
----
N
D
W
L
G
N
L
----------------
P
---
Y
-
E
Y
--
K
----
I
V
I
A
G
-----------
N
H
E
L
T
F
--
D
K
E
-----------------
F
---
M
--
A
D
-
L
-
V
-
K
Q
DYYRF
P
S
V
S
K
LKPEDFDNVQSL
L
T
N
-
S
-----
I
-----
Y
L
-
Q
D
-----
S
---------
E
-
V
----------
T
------
V
------
K
--
G
--
F
R
I
Y
----
G
A
P
W
T
P
W
-GWGF--------------
N
-------------
L
------
P
--------
R
G
-
Q
S
-----
L
L
D
K
----
W
N
L
-
I
----
P
E
G
T
---
D
I
L
M
T
H
G
--
P
----------------
P
L
--
G
--
F
RDWVPKEL
Q
R
V
G
C
V
E
L
L
N
T
-------------
V
Q
R
-
R
V
R
P
K
L
H
V
F
---
G
G
I
H
E
G
Y
----------------------
G
T
M
T
-----
D
G
Y
T
T
--------
Y
I
N
A
S
T
C
T
V
S
F
Q
P
T
N
P
P
--
I
I
F
D
L
P
N
P
-------
7
PsiBlast_PDB
62.89
24%
-52
- C2 -
3AUZ
3
MRE11_METJA
A:
[62-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
V
L
H
S
G
D
L
F
N
D
-
L
R
-
P
------
P
-------------------------
V
K
A
L
----
R
I
A
M
Q
A
F
----------------
K
--
K
L
-
H
E
--
N
N
I
K
V
Y
I
V
A
G
-----------
N
H
E
M
P
R
RL
G
E
E
-----------------
S
---
P
--
L
A
-
L
-
L
-
K
-----------------------
D
Y
V
-
K
-----
I
-----
L
D
-
G
K
-----
D
---------
V
-
I
----------
N
------
V
------
N
--
G
E
E
I
F
I
C
----
G
T
Y
Y
H
K
K
S
------------------
K
-------------
R
------
E
--------
E
M
-
L
D
-----
K
L
K
N
---
F
E
S
E
-
A
--
K
-
N
Y
K
K
---
K
I
L
M
L
H
Q
G
I
N
----------------
P
Y
--
I
--
P
------------------
L
-------------
D
Y
E
-
L
E
H
F
D
L
P
K
F
---
S
Y
Y
A
L
G
H
I
H
K
----------
R
I
-
L
E
R
F
N
D
G
I
L
A
--
Y
-
S
G
S
T
E
I
IYRNE
Y
E
D
Y
K
K
E
G
K
G
F
Y
L
V
D
F
S
G
N
D
--
L
D
I
S
D
I
E
K
I
D
I
E
C
R
E
40
HHSearch
62.35
19%
-95
- C2 -
1S3L
2
P936_METJA
A:
[26-183]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
G
I
M
S
D
T
H
D
H
L
-------------------------------------------
P
N
I
R
K
A
I
E
I
F
N
D
--
E
--
N
V
E
T
V
I
H
C
G
D
F
V
S
L
-
F
--------------------------------------
V
----
I
K
E
F
E
N
L
--------------------
N
-
A
N
--
I
----
I
A
T
Y
G
-----------
N
N
D
G
E
R
--
C
K
L
------------------------
K
E
-
W
-
L
-
K
------------------------------------------------------------------------
D
------
I
------
N
--
E
--
E
N
I
I
---------------------------------------------------------------
D
D
-----
F
I
S
V
-----------
E
-
I
D
D
L
---
K
F
F
I
T
H
G
--
H
----------------
H
Q
--
S
V
L
E
------------------
M
-------------
A
I
K
-
S
G
L
Y
D
V
V
I
Y
---
G
H
T
H
E
R
V
F
E
-----------------------
E
----
V
-
D
D
V
L
--------
V
I
N
P
G
E
C
C
G
---
Y
L
T
G
---
I
P
T
I
G
I
L
D
T
E
K
K
E
Y
R
49
Fugue
61.61
17%
-76
- C2 -
4Q0W
4
RAD2_YEAST
A:
[1-362]
-----------------------------
G
V
H
S
F
W
D
I
A
G
P
T
A
---
R
P
V
R
L
E
--------
S
L
-
E
--
D
K
R
M
A
V
D
A
S
I
W
I
Y
Q
F
L
K
A
V
RDQN
A
V
K
N
S
H
I
T
G
F
F
R
R
I
C
K
L
L
Y
F
G
I
R
P
V
F
V
F
D
G
G
V
P
V
------
L
K
R
E
T
I
R
Q
R
K
E
R
R
Q
G
K
R
E
-----------------------
D
E
V
T
M
D
M
I
--
K
E
V
Q
E
L
L
S
-----
R
F
---
G
I
P
Y
I
T
A
P
M
E
A
E
A
Q
C
A
E
L
L
--------
Q
----------------------
L
---------
N
L
V
D
G
I
I
T
D
D
S
--------
D
V
F
L
F
G
G
T
K
I
Y
K
-
N
M
-----------------------------------------------
F
H
----------------
E
--
K
N
-
Y
V
--
E
----
F
Y
D
A
E
-----------
S
I
L
K
L
L
--
G
--------------------------
L
D
-
R
-
K
-
N
-----------------------
M
I
E
-
L
-----
A
-----
Q
L
L
G
S
-----
D
---------
Y
-
T
----------
N
G-----
L
------
K
--
G
--
M
G
P
V
----
S
S
I
E
V
I
A
E
------------------
F
-------------
G
N
L
----
K
--------
N
F
-
K
D
-----
W
Y
N
N
---
G
Q
F
D
-
K
--
R
-
K
Q
E
T
---
E
---
N
K
F
--
E
----------------
K
D
--
L
--
R
------------------
K
-------------
K
L
V
-
N
N
E
I
I
L
D
D
D
---
F
P
S
----------------
V
M
V
-
Y
D
A
Y
M
R
P
E
V
D
--
H
-
D
T
T
P
F
V
--------
W
G
V
P
D
L
D
M
L
R
S
F
M
K
T
Q
L
GW
P
H
E
K
S
D
E
I
L
I
P
L
I
--
35
HHSearch
61.48
14%
-87
- C2 -
3TGH
6
?
A:
[2-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
L
R
F
A
S
L
G
D
W
G
K
D
T
K
G
--------
Q
----------------------
I
---------
L
N
A
K
Y
F
K
Q
F
I
K
N
--
E
--
R
V
T
F
I
V
S
P
G
S
N
F
I
D
-
G
V
-
K
GL----
N
-------------------------
D
P
A
W
KNLY
E
D
V
Y
S
E
E
----------------
K
GD
M
Y
-
M
P
--
F
----
F
T
V
L
G
-----------
T
R
D
W
T
G
--
N
Y
N
-----------------
A
Q
--
L
L
K
G
Q
G-----DATN-------------------
Y
P
K
-
W
-----
I
------
M
-
P
N
-----
Y
---------
W
-
Y
----------
H
Y
F
T
H
F
T
V
SH
K
D
--
L
--
A
--
A
A
F
I
----
F
I
D
T
W
V
L
S
SNFPY
K
K
-----------
I
-------------
H
------
E
--------
K
A
-
W
N
-----
D
L
K
S
---
Q
L
S
V
-
A
K
-
K
-
I
A
D
F
---
I
I
V
V
G
D
Q
--
P
----------------
I
Y
--
S
--
S
GYSRGS
S
Y
L
A
Y
Y
L
L
----
P
-------------
L
L
K
-
D
A
E
V
D
L
Y
I
S
---
G
H
D
N
N
M
E
V
I
E
---
D
-
N
D
-
M
A
H
I
-
T
C
G
S
G
S
M
S
Q
G
--
K
-
S
G
M
K
N
S
--------
K
S
L
F
F
S
S
D
I
G
F
C
V
H
E
L
S
--
N
N
G
I
V
T
K
F
V
S
S
K
K
G
E
27
HHSearch
61.34
16%
-87
- C2 -
1UTE
4
PPA5_PIG
A:
[4-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
P
I
L
R
F
V
A
V
G
D
W
G
G
V
P
N
A
--------
P
----------------------
F
HT
A
R
E
M
---
A
N
A
K
A
I
A
T
T
V
K
T
--
L
--
G
A
D
F
I
L
S
L
G
D
N
F
Y
F
-
T
G
-
V
HDA---
K
-------------------------
D
K
R
F
----
Q
E
T
F
E
D
V
FSDPS-----------
L
--
R
N
-
V
P
--
W
----
H
V
L
A
G
-----------
N
H
D
H
L
G
--
N
V
S
-----------------
A
Q
I
A
Y
--
S
K
-
I
-
S
-
K
-----------------------
R
W
N
--------------
F
-
P
S
-----
P
---------
Y
-
Y
R
L
--------
R
------
F
K
IPRSN
V
--
S
--
V
A
I
F
----
M
L
D
T
V
T
L
C
GNSDDFVSQQPERPRN
L
A
L
-------------
A
------
R
--------
T
Q
-
L
A
-----
W
I
K
K
---
Q
L
A
A
-
A
----
K
E
D
Y
---
V
L
V
A
G
H
Y
--
P
----------------
V
W
--
S
--
I
AEHGPT
H
C
L
V
K
QL
L
----
P
-------------
L
L
T
-
T
H
K
V
T
A
Y
L
C
---
G
H
D
H
N
L
Q
Y
L
Q
---
D
-
E
N
-
G
L
G
F
-
V
L
S
G
A
G
N
F
M
D
--
P
-
S
K
K
H
L
R
--------
K
V
P
N
G
Y
L
R
F
H
F
G
A
E
N
S
L
--
G
G
F
A
Y
V
E
I
T
P
K
E
M
S
V