@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0383: (2015-12-14 )
MANERSKLAFKKTFPVFKRFLQSKDLALVVFVIAILAIIIVPLPPFVLDFLLTISIALSVLIILIGLYIDKPTDFSAFPTLLLIVTLYRLALNVATTRMILTQGYKGPSAVSDIITAFGEFSVSGNYVIGAIIFSILVLVNLLVVTNGSTRVTEVRARFALDAMPGKQMAIDADLNSGLIDDKEAKKRRAALSQEADFYGAMDGASKFVKGDAIASIIITLINIIGGFLVGVFQRDMSLSFSASTFTILTIGDGLVGQIPALIIATATGIVATRTTQNEEEDFASKLITQLTNKSKTLVIVGANLLLFATIPGLPTFSLAFVGTLFLFIAWLISREGKDGLLTKLENYLSQKFGLDLSEKPHSSKIKPHAPTTKTKTPEEIKREEEQAIDEVLKIEFLELALGYQLISLADMKQGGDLLERIRGIRKKIASDYGFLMPQIRIRDNLQLPPTHYEIKLKGIVIGEGMVMPDKFLAMNTGFVNREIEGIPTKEPAFGMDALWIDAKNKEEAIIQGYTIIDPSTVIATHTSELVKKYAEDFITKDEVKSLLERLAKDYPTIVEESKKIPTGAIRSVLQALLHEKIPIKDMLTILETITDIAPLVQNDVNILTEQVRARLSRVITNAFKSEDGRLKFLTFSTDSEQFLLNKLRENGTSKSLLLNVGELQKLIEGVSEEAMKVLQKGIAPVILIVEPNLRKALSNQMEQARIDVVVLSHAELDPNSNFEALGTIHINF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230....---------...240....-.-..250........-260.......270.......280---------.........290....-----...300.......310---.......-.320.......-330.......340......-----.350.......360..-..--...370.......380.......-----390.......-400.......410...-....420.........430.......440.......450.......460........470.......480...-..-..490........500.......510..--.....520.......530.......540.......550.......560-..--.-...-..570.......580.......590.......600.-......610.......620..------.....630......---.640...--....650.......660.......670.......680...--..-..690--........700.......710.......720.......730.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAN
E
R
S
K
L
A
F
K
K
T
F
P
V
F
K
R
F
LQSK
D
L
A
L
V
V
F
V
I
A
I
L
A
I
I
IVPL
P
P
F
V
L
D
F
L
L
T
I
S
I
A
L
S
V
L
I
I
L
I
G
L
YIDKPTDF
S
A
F
P
T
L
L
L
I
V
T
L
Y
R
L
A
L
N
V
A
T
T
R
M
I
L
TQGYKG
P
S
A
V
S
D
I
I
T
A
F
GEFSVSG
N
Y
V
I
G
A
I
I
F
S
I
L
V
L
V
N
L
L
VVTNGS
T
R
V
T
E
V
R
A
R
F
ALDAMPGK
Q
M
A
I
DADLNSGLID
D
K
E
A
K
K
R
R
A
A
LSQEA
D
F
YGAMD
G
A
S
K
F
VK
G
D
A
I
A
S
I
I
I
T
L
I
N
I
I
G
G
F
L
V
G
V
F
Q
RD---------M
S
L
S
FSA
S
T
F
-
T
-
I
L
T
-IGD
G
L
V
G
QI-
P
A
L
I
I
A
TAT
G
I
V
A
TRTTQN
E
E
-----------
E
D
F
A
S
K
L
I
T
Q
L
TNKS
K
-----
T
L
V
I
VGA
N
L
L
L
F
A
TI----PGLP
T
F
S
-
L
A
F
V
G
T
L
F
L
F
I
-
A
W
L
I
SREGK
D
G
L
L
T
K
L
E
N
Y
-----
L
S
Q
K
FGLDLSEKPHSS-KI--KPHAPTTKTK
T
P
E
E
I
K
R
E
E
E
Q
A
I
-----
D
E
V
L
K
I
E
F
L
E
-
L
A
L
G
Y
Q
L
I
S
L
A
D
M
KQ
G
-
G
D
L
L
E
--
R
I
R
G
I
R
K
K
I
A
S
DYGFL
M
P
Q
I
R
I
RDNLQLPP
T
H
Y
E
I
K
L
K
G
I
-
V
IGEGMVMP
D
K
F
L
A
MNTGFVNREIE-GI-PTKE-PAFGM
D
A
L
W
I
DAKNKE
E
A
I
I
Q
G
Y
--
T
IIDP
S
T
V
I
AT
H
T
S
E
L
V
K
K
Y
A
E
DFI
T
K
D
E
V
K
S
L
L
E
R
L
A
K
DY
P
T
I
V
E
E--SK--K-I
P
T
-
G
A
I
R
S
V
L
Q
A
L
L
HEKI
P
I
K
D
M
L
T
I
L
E
T
I
T
D
I
A
P
L
V
QN-
D
V
N
I
L
T
E
Q
V
R
A
R
L
S
R
V
I
T
N
A
F------KSEDG
R
L
K
F
L
T
FST---D
S
E
Q
F
L
L
--
N
K
L
R
ENGTS
K
S
L
L
L
N
V
G
E
L
Q
K
L
I
E
G
V
S
E
E
A
M
K
V
L
Q
KGI
A
P
--
V
I
-
L
I
VE---P
N
L
R
K
A
L
S
N
Q
M
E
Q
A
R
I
D
V
V
V
L
S
H
AELDPNSN
F
E
A
L
G
T
I
H
INF
1
PsiBlast_PDB
97.51
98%
-110
- C3 -
3MYD
-
FLHA_HELPY
A:
[385-732]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
Q
A
I
-----
D
E
V
L
K
I
E
F
L
E
-
L
A
L
G
Y
Q
L
I
S
L
A
D
M
K
Q
G
-
G
D
L
L
E
--
R
I
R
G
I
R
K
K
I
A
S
D
Y
G
F
L
M
P
Q
I
R
I
R
D
N
L
Q
L
P
P
T
H
Y
E
I
K
L
K
G
I
-
V
I
G
E
G
M
V
M
P
D
K
F
L
A
M
N
T
G
F
V
N
R
E
I
E
-
G
I
-
P
T
K
E
-
P
A
F
G
M
D
A
L
W
I
D
A
K
N
K
E
E
A
I
I
Q
G
Y
--
T
I
I
D
P
S
T
V
I
A
T
H
T
S
E
L
V
K
K
Y
A
E
D
F
I
T
K
D
E
V
K
S
L
L
E
R
L
A
K
D
Y
P
T
I
V
E
E
--
S
K
--
K
-
I
P
T
-
G
A
I
R
S
V
L
Q
A
L
L
H
E
K
I
P
I
K
D
M
L
T
I
L
E
T
I
T
D
I
A
P
L
V
Q
N
-
D
V
N
I
L
T
E
Q
V
R
A
R
L
S
R
V
I
T
N
A
F
------
K
S
E
D
G
R
L
K
F
L
T
F
S
T
---
D
S
E
Q
F
L
L
--
N
K
L
R
E
N
G
T
S
K
S
L
L
L
N
V
G
E
L
Q
K
L
I
E
G
V
S
E
E
A
M
K
V
L
Q
K
G
I
A
P
--
V
I
-
L
I
V
E
---
P
N
L
R
K
A
L
S
N
Q
M
E
Q
A
R
I
D
V
V
V
L
S
H
A
E
L
D
P
N
S
N
F
E
A
L
G
T
I
H
I
N
-
16
HHSearch
95.64
96%
-110
- C3 -
3MYD
-
FLHA_HELPY
A:
[385-732]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
Q
A
I
-----
D
E
V
L
K
I
E
F
L
E
-
L
A
L
G
Y
Q
L
I
S
L
A
D
M
K
Q
G
-
G
D
L
L
E
--
R
I
R
G
I
R
K
K
I
A
S
D
Y
G
F
L
M
P
Q
I
R
I
R
D
N
L
Q
L
P
P
T
H
Y
E
I
K
L
K
G
I
-
V
I
G
E
G
M
V
M
P
D
K
F
L
A
M
N
T
G
F
V
N
R
E
I
E
-
G
I
-
P
T
K
E
-
P
A
F
G
M
D
A
L
W
I
D
A
K
N
K
E
E
A
I
I
Q
G
Y
--
T
I
I
D
P
S
T
V
I
A
T
H
T
S
E
L
V
K
K
Y
A
E
D
F
I
T
K
D
E
V
K
S
L
L
E
R
L
A
K
D
Y
P
T
I
V
E
E
--
S
K
--
K
-
I
P
T
-
G
A
I
R
S
V
L
Q
A
L
L
H
E
K
I
P
I
K
D
M
L
T
I
L
E
T
I
T
D
I
A
P
L
-
V
Q
N
D
V
N
I
L
T
E
Q
V
R
A
R
L
S
R
V
I
T
N
A
F
------
K
S
E
D
G
R
L
K
F
L
T
F
S
T
---
D
S
E
Q
F
L
L
--
N
K
L
R
E
N
G
T
S
K
S
L
L
L
N
V
G
E
L
Q
K
L
I
E
G
V
S
-
E
E
A
M
K
V
L
Q
K
G
I
A
--
P
V
I
L
I
V
E
---
P
N
L
R
K
A
L
S
N
Q
M
E
Q
A
R
I
D
V
V
V
L
S
H
A
E
L
D
P
N
S
N
F
E
A
L
G
T
I
H
I
N
-
17
HHSearch
77.35
38%
-94
- C3 -
3A5I
-
FLHA_SALTY
A:
[347-691]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
V
V
E
A
T
W
-----
N
D
V
Q
L
E
D
S
L
G
-
M
E
V
G
Y
R
L
I
P
M
V
D
F
Q
Q
D
-
G
E
L
L
G
--
R
I
R
S
I
R
K
K
F
A
Q
D
M
G
F
L
P
P
V
V
H
I
R
D
N
M
D
L
Q
P
A
R
Y
R
I
L
M
K
G
V
-
E
I
G
S
G
D
A
Y
P
G
R
W
L
A
I
N
P
G
T
A
A
G
T
L
P
-
G
E
-
K
T
V
D
-
P
A
F
G
L
D
A
I
W
I
E
S
A
L
K
E
Q
A
Q
I
Q
G
F
--
T
V
V
E
A
S
T
V
V
A
T
H
L
N
H
L
I
G
Q
F
S
A
E
L
F
G
R
Q
E
A
Q
Q
L
L
D
R
V
S
Q
E
M
P
K
L
T
E
D
--
L
V
PG
V
-
V
T
L
-
T
T
L
H
K
V
L
Q
N
L
L
A
E
K
V
P
I
R
D
M
R
T
I
L
E
T
L
A
E
H
A
P
L
-
Q
S
-
D
P
H
E
L
T
A
V
V
R
V
A
L
G
R
A
I
T
Q
Q
W
------
F
P
G
N
E
E
V
Q
V
I
G
L
D
T
---
A
L
E
R
L
L
L
--
Q
A
L
Q
G
G
-----
G
G
L
E
P
G
L
A
D
R
L
L
A
Q
T
Q
-
E
A
L
S
R
Q
E
M
L
G
A
P
--
P
V
-
L
L
V
N
---
H
A
L
R
P
L
L
S
R
F
L
R
R
S
L
P
Q
L
V
V
L
S
N
L
E
L
S
D
N
R
H
I
R
M
T
A
T
I
G
G
--
2
PsiBlast_PDB
77.32
36%
-97
- C3 -
3A5I
-
FLHA_SALTY
A:
[347-689]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
V
V
E
A
T
W
N
D
V
Q
L
E
D
S
L
G
-
M
E
V
G
Y
R
L
I
P
M
V
D
F
Q
Q
D
-
G
E
L
L
G
--
R
I
R
S
I
R
K
K
F
A
Q
D
M
G
F
L
P
P
V
V
H
I
R
D
N
M
D
L
Q
P
A
R
Y
R
I
L
M
K
G
V
-
E
I
G
S
G
D
A
Y
P
G
R
W
L
A
I
N
P
G
T
A
A
G
T
L
P
-
G
E
-
K
T
V
D
-
P
A
F
G
L
D
A
I
W
I
E
S
A
L
K
E
Q
A
Q
I
Q
G
F
--
T
V
V
E
A
S
T
V
V
A
T
H
L
N
H
L
I
G
Q
F
S
A
E
L
F
G
R
Q
E
A
Q
Q
L
L
D
R
V
S
Q
E
M
P
K
L
T
E
D
LV
P
G
--
V
-
V
T
L
-
T
T
L
H
K
V
L
Q
N
L
L
A
E
K
V
P
I
R
D
M
R
T
I
L
E
T
L
A
E
H
A
P
L
-
Q
S
-
D
P
H
E
L
T
A
V
V
R
V
A
L
G
R
A
I
T
Q
Q
W
------
F
P
G
N
E
E
V
Q
V
I
G
L
D
T
---
A
L
E
R
L
L
L
--
Q
A
L
Q
G
G
G
G
-----
L
E
P
G
L
A
D
R
L
L
-
A
Q
T
Q
E
A
L
S
R
Q
E
M
L
G
A
P
--
P
V
-
L
L
V
N
---
H
A
L
R
P
L
L
S
R
F
L
R
R
S
L
P
Q
L
V
V
L
S
N
L
E
L
S
D
N
R
H
I
R
M
T
A
T
I
G
G
K
-
24
Fugue
74.50
33%
-91
- C3 -
3MIX
-
FLHA_BACSU
A:
[318-676]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
E
E
E
A
E
V
D
E
L
K
S
P
E
S
V
-----
V
Q
L
L
H
I
D
P
I
E
-
F
E
F
G
Y
G
L
I
P
L
A
D
A
N
Q
G
-
G
D
L
L
D
--
R
I
V
M
I
R
R
Q
L
A
L
E
L
G
L
V
I
P
V
V
R
I
R
D
N
I
A
L
Q
P
N
E
Y
R
L
K
I
K
G
N
-
E
V
A
K
G
E
L
L
L
D
H
Y
L
A
---------------------------------------------
T
V
V
D
P
A
S
V
V
S
T
H
I
T
E
K
I
K
Q
H
A
H
E
L
I
G
R
Q
E
T
K
Q
L
I
D
H
L
K
E
S
Y
P
V
L
V
E
E
V
T
P
N
--
P
-
L
S
V
-
G
D
I
Q
K
V
L
A
K
L
L
K
E
K
V
S
I
R
N
L
V
T
I
F
E
T
L
A
D
Y
G
K
-
L
T
T
-
D
S
D
L
L
T
E
Y
T
R
Q
A
L
A
K
Q
I
T
A
Q
F
------
A
K
E
N
E
V
L
K
V
V
T
C
S
G
---
R
V
E
K
A
I
A
--
D
G
V
Q
------
Y
L
S
L
E
P
D
I
S
E
S
I
V
R
S
V
A
K
E
A
E
Q
L
S
L
R
Q
E
T
A
---
I
-
L
L
C
S
---
P
P
V
R
M
Y
V
K
Q
L
L
E
R
Y
F
P
D
L
P
V
L
S
Y
N
E
L
E
A
N
V
E
V
Q
S
I
G
V
V
D
---
18
HHSearch
67.27
21%
-80
- C3 -
2X49
6
A:
[4-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
E
T
V
P
L
I
-
L
L
V
P
K
S
R
R
E
D
L
E
-------
K
A
Q
--
L
A
E
R
L
R
S
Q
F
F
I
D
Y
G
V
R
L
P
E
V
L
L
R
D
G
E
G
L
D
D
N
S
I
V
L
L
I
N
E
I
-
R
V
E
Q
F
T
V
Y
F
D
L
M
R
V
V
N
Y
S
D
E
V
V
-
S
F
-
G
I
N
P
T
I
H
-
Q
Q
G
S
S
Q
Y
F
W
V
T
H
E
E
G
E
K
L
R
E
L
G
Y
--
V
L
R
N
A
L
D
E
L
Y
H
C
L
A
V
T
L
A
R
N
V
N
E
Y
F
G
I
Q
E
T
K
H
M
L
D
Q
L
E
A
K
F
P
D
L
L
K
E
--
V
L
R
-
H
-
A
T
V
-
Q
R
I
S
E
V
L
Q
R
L
L
S
E
R
V
S
V
R
N
M
K
L
I
M
E
A
L
A
L
W
A
P
R
-
E
K
-
D
V
I
N
L
V
E
H
I
R
G
A
M
A
R
Y
I
C
H
K
F
------
A
N
G
-
G
E
L
R
A
V
M
V
S
A
---
E
V
E
D
V
I
R
--
K
G
I
R
Q
T
S
G
S
T
F
L
S
L
D
P
E
A
S
A
N
L
M
D
L
I
T
-
L
K
L
D
D
L
L
I
A
H
K
D
--
L
V
-
L
L
T
S
---
V
D
V
R
R
F
I
K
K
M
I
E
G
R
F
P
D
L
E
V
L
S
F
G
E
I
A
D
S
K
S
V
N
V
I
K
T
I
----
23
Fugue
66.79
21%
-68
- C3 -
2X49
6
A:
[1-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
H
-
M
T
E
T
V
P
L
I
L
L
V
P
K
S
R
R
-
E
D
L
E
K
A
Q
L
A
E
R
L
R
S
Q
F
F
I
D
Y
G
V
R
L
P
E
V
L
L
R
D
G
E
G
L
D
D
N
S
I
V
L
L
I
N
E
I
-
R
V
E
Q
F
T
V
Y
F
D
L
M
R
V
V
N
Y
S
D
E
V
V
S
F
G
-
I
N
-
P
T
I
H
-
Q
Q
G
S
S
Q
Y
F
W
V
T
H
E
E
G
E
K
L
R
E
L
G
Y
--
V
L
R
N
A
L
D
E
L
Y
H
C
L
A
V
T
L
A
R
N
V
N
E
Y
F
G
I
Q
E
T
K
H
M
L
D
Q
L
E
A
K
F
P
D
L
L
K
E
--
V
L
--
R
H
A
T
V
-
Q
R
I
S
E
V
L
Q
R
L
L
S
E
R
V
S
V
R
N
M
K
L
I
M
E
A
L
A
L
W
A
P
R
-
E
K
-
D
V
I
N
L
V
E
H
I
R
G
A
M
A
R
Y
I
C
H
K
F
------
A
-
N
G
G
E
L
R
A
V
M
V
S
A
---
E
V
E
D
V
I
R
--
K
G
I
R
Q
T
S
G
S
T
F
L
S
L
D
P
E
A
S
A
N
L
M
D
L
I
T
L
K
L
D
D
L
L
I
A
H
K
D
L
--
V
L
-
L
T
-
S
---
V
D
V
R
R
F
I
K
K
M
I
E
G
R
F
P
D
L
E
V
L
S
F
G
E
I
A
D
S
K
S
V
N
V
I
K
T
I
----
4
PsiBlast_PDB
65.11
21%
-80
- C3 -
2X4A
3
A:
[31-333]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
Q
F
F
I
D
Y
G
V
R
L
P
E
V
L
L
R
D
G
E
G
L
D
D
N
S
I
V
L
L
I
N
E
I
-
R
V
E
Q
F
T
V
Y
F
D
L
M
R
V
V
N
--
Y
S
D
E
V
V
S
F
G
I
N
P
T
I
H
-
Q
Q
G
S
S
Q
Y
F
W
V
T
H
E
E
G
E
K
L
R
E
L
G
Y
--
V
L
R
N
A
L
D
E
L
Y
H
C
L
A
V
T
L
A
R
N
V
N
E
Y
F
G
I
Q
E
T
K
H
M
L
D
Q
L
E
A
K
F
P
D
L
L
K
E
--
V
L
--
R
-
H
A
T
V
Q
R
I
S
E
V
L
Q
R
L
L
S
E
R
V
S
V
R
N
M
K
L
I
M
E
A
L
A
L
W
A
P
R
E
K
D
-
V
I
N
-
L
V
E
H
I
R
G
A
M
A
R
Y
I
C
H
K
F
-------
A
N
G
G
E
L
R
A
V
M
V
S
A
---
E
V
E
D
V
I
R
--
K
G
I
R
Q
T
S
G
S
T
F
L
S
L
D
P
E
A
S
A
N
L
M
D
L
I
T
---
L
K
L
D
D
L
L
I
A
H
KD
L
V
-
L
L
T
S
---
V
D
V
R
R
F
I
K
K
M
I
E
G
R
F
P
D
L
E
V
L
S
F
G
E
I
A
D
S
K
S
V
N
V
I
K
T
I
----
3
PsiBlast_PDB
64.14
21%
-80
- C3 -
2X49
6
A:
[31-333]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
Q
F
F
I
D
Y
G
V
R
L
P
E
V
L
L
R
D
G
E
G
L
D
D
N
S
I
V
L
L
I
N
E
I
-
R
V
E
Q
F
T
V
Y
F
D
L
M
R
V
V
N
--
Y
S
D
E
V
V
S
F
G
I
N
P
T
I
H
-
Q
Q
G
S
S
Q
Y
F
W
V
T
H
E
E
G
E
K
L
R
E
L
G
Y
--
V
L
R
N
A
L
D
E
L
Y
H
C
L
A
V
T
L
A
R
N
V
N
E
Y
F
G
I
Q
E
T
K
H
M
L
D
Q
L
E
A
K
F
P
D
L
L
K
E
--
V
L
--
R
-
H
A
T
V
Q
R
I
S
E
V
L
Q
R
L
L
S
E
R
V
S
V
R
N
M
K
L
I
M
E
A
L
A
L
W
A
P
R
E
K
D
-
V
I
N
-
L
V
E
H
I
R
G
A
M
A
R
Y
I
C
H
K
F
-------
A
N
G
G
E
L
R
A
V
M
V
S
A
---
E
V
E
D
V
I
R
--
K
G
I
R
Q
T
S
G
S
T
F
L
S
L
D
P
E
A
S
A
N
L
M
D
L
I
T
---
L
K
L
D
D
L
L
I
A
H
KD
L
V
-
L
L
T
S
---
V
D
V
R
R
F
I
K
K
M
I
E
G
R
F
P
D
L
E
V
L
S
F
G
E
I
A
D
S
K
S
V
N
V
I
K
T
I
----
5
PsiBlast_PDB
44.91
27%
-50
- C3 -
4UOS
-
?
A:
[5-139]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
V
K
K
M
L
E
K
M
-------
I
E
E
--
I
K
--
K
-
M
L
E
-
K
A
I
K
K
V
K
E
M
L
--
E
K
M
-
I
K
E
I
K
K
M
L
E
N
G
E
D
S
E
K
I
L
K
K
--
A
K
E
M
A
E
K
I
---
L
K
M
V
I
E
L
A
E
-------------
K
I
L
K
K
A
K
---
E
M
A
E
K
I
L
--
K
K
V
K
E
L
G
V
D
N
E
------
E
V
K
K
M
L
E
K
M
I
E
E
I
K
K
M
L
E
K
A
I
K
K
--
V
K
-
E
M
L
E
K
M
I
K
E
I
K
K
M
L
E
N
G
E
D
S
E
K
I
L
K
K
A
K
E
M
A
E
K
I
L
K
M
V
I
E
L
A
E
K
I
L
K
K
A
29
Fugue
42.02
14%
-36
- C3 -
1HE1
3
?
A:
[1-135]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
S
A
V
V
F
K
Q
M
V
L
Q
Q
A
L
P
M
T
L
K
G
L
-
D
K
A
S
E
--
L
A
--
T
-
L
T
P
-
E
G
L
A
R
E
H
S
R
L
A
S
G
D
G
A
L
R
S
L
S
T
A
L
A
G
I
R
A
G
S
Q
----------
V
E
E
S
R
I
Q
A
G
R
L
L
E
R
S
I
----------
G
G
I
A
L
Q
Q
W
G
T
TGG
A
A
S
Q
L
V
L
D
A
S
P
E
L
R
R
E
I
T
D
Q
L
H
Q
V
M
S
E
V
A
L
L
R
Q
A
V
E
S
E
V
S
---------------------------------------------------------------
25
Fugue
31.74
21%
71
- C3 -
4O8W
-
?
A:
[14-123]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
K
E
T
L
Q
Q
M
L
T
S
D
Q
G
K
K
F
W
E
S
A
L
K
D
-
P
K
F
A
E
S
--
F
A
--
K
-
G
L
Q
-
A
E
H
E
K
M
M
R
A
L
M
K
D
P
D
Y
Q
A
L
M
I
D
I
L
K
D
P
E
M
E
K
A
M
V
D
V
-
L
K
---
S
K
E
F
R
Q
H
L
Q
K
V
I
T
E
T
L
------
N
S
P
L
Y
Q
A
K
I
Q
D
M
L
M
---
K
A
A
E
K
--------------------------------------------------------------------------------------------------
30
Fugue
31.29
11%
3
- C2 -
2P03
-
AMRP_HUMAN
A:
[1-323]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
S
R
E
K
N
Q
P
K
P
S
P
K
R
E
S
G
-
E
E
FR
M
E
K
L
N
Q
L
W
E
K
A
Q
R
L
H
L
P
P
V
R
L
A
E
-----
L
H
A
D
L
K
I
Q
E
R
-
D
E
L
A
W
K
K
L
K
L
D
G
L
D
E
D
-
G
E
K
E
A
--
R
L
I
R
N
L
N
V
I
L
A
K
Y
G
L
D
----
G
K
K
D
A
R
Q
V
T
S
N
S
L
S
G
T
Q
E
D
G
-
L
D
D
P
R
L
E
K
L
W
H
K
A
K
T
S
G
K
F
S
G
E
E
L
D
-
K
L
-
W
R
E
F
-
L
H
H
K
E
K
V
H
E
Y
N
V
L
L
E
T
L
S
R
T
E
E
I
HE
N
V
I
S
P
S
D
L
S
D
I
K
G
S
V
L
H
S
R
H
T
E
L
K
E
K
L
R
S
I
N
Q
G
L
D
R
L
R
R
V
S
H
Q
G
Y
S
T
--
E
A
--
E
-
F
E
E
-
P
R
V
I
D
L
W
D
L
A
Q
S
A
N
L
T
D
K
E
L
E
A
F
R
E
E
L
K
H
F
E
A
K
I
E
K
-
H
N
H
Y
Q
K
Q
L
E
I
A
H
E
K
L
R
H
A
E
S
V
GDGER
V
S
R
S
R
E
K
H
A
L
L
E
G
R
T
---
K
E
L
G
Y
T
V
--
K
K
H
L
Q
D
L
S
G
R
I
S
R
A
R
H
N
E
L
---------------------------------------------------------------------------
13
PsiBlast_PDB
29.73
48%
365
- C3 -
2ORM
-
Y924_HELPY
A:
[20-46]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
L
I
E
G
V
S
D
L
M
V
K
V
L
N
K
N
K
A
S
--
I
V
-
V
I
I
D
---
E
V
D
S
N
N
Y
G
L
G
G
E
S
V
H
H
L
R
Q
K
N
---------------------
26
Fugue
29.21
26%
358
- C3 -
2KYG
-
C:
[578-615]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
M
A
D
I
G
S
A
S
G
Y
V
P
E
E
I
W
K
K
A
E
E
A
V
-----
N
E
V
K
R
Q
A
M
T
E
-
L
Q
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
29.13
33%
622
- C3 -
3ECH
-
?
C:
[2-25]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
T
E
Q
L
R
R
A
A
R
R
N
A
W
D
L
Y
G
E
H
F
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
28.49
14%
-3
- C1 -
4W9R
5
?
A:
[4-363]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
I
S
E
T
F
S
S
G
R
L
N
R
K
Q
K
I
G
I
Y
K
P
E
KYTDR
Q
A
Y
P
L
I
V
V
L
N
A
E
T
L
M
E
P
V
V
S
M
V
R
Y
Y
E
Q
F
G
E
M
P
K
C
I
V
V
G
V
Y
E
P
K
Q
E
D
V
T
V
V
E
E
VGRPI
N
E
S
A
R
F
F
E
F
V
S
A
E
L
V
P
Y
I
Q
G
K
Y
PIAD
L
K
G
V
I
A
S
E
E
A
G
F
L
A
N
Y
Y
M
L
A
E
K
K
P
T
F
N
M
I
V
S
L
N
P
V
A
L
P
R
M
G
E
E
F
S
H
A
L
A
A
G
V
P
N
R
L
F
Y
Y
M
A
T
A
D
V
E
N
K
V
V
Y
D
K
A
I
Q
F
E
R
A
M
R
S
--
A
P
V
H
E
S
V
E
Y
H
F
V
D
F
K
G
S
S
V
N
A
A
K
-----
L
Q
G
I
A
-
Q
A
L
D
M
C
F
D
I
Y
K
P
I
G
G
K
E
F
K
T
Q
M
E
T
L
E
T
-----
G
I
Y
E
Y
L
E
N
K
Y
N
T
I
Y
K
Q
L
G
V
K
---------
K
V
P
I
L
N
D
V
M
A
T
Y
T
A
I
N
S
S
Q
D
W
E
S
L
K
K
L
A
K
Y
V
E
S
N
-
G
Y
-
L
K
T
A
M
P
N
F
-
F
L
A
E
Y
Y
E
K
I
G
D
D
K
K
A
L
K
T
Y
--
Q
K
A
Y
T
E
P
N
I
D
F
I
T
G
D
L
I
N
E
R
I
T
H
L
Q
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
27.59
48%
330
- C3 -
3M21
-
Y924_HELPY
A:
[20-46]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
L
I
E
G
V
S
D
L
M
V
K
V
L
N
K
N
K
A
S
--
I
V
-
V
I
I
D
---
E
V
D
S
N
N
Y
G
L
G
G
E
S
V
H
H
L
R
Q
-----------------------
32
Fugue
24.47
22%
550
* C3 *
4H7R
4
?
A:
[4-31]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
I
K
A
I
A
Q
E
I
K
A
I
A
K
E
I
K
A
I
A
W
E
--
I
K
--
A
-
I
A
Q
-
G
Y
N
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
24.47
21%
130
- C3 -
1WAZ
-
?
A:
[27-68]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
I
L
L
G
V
V
G
L
S
A
L
T
----
G
Y
L
D
Y
V
L
-
L
P
A
L
A
I
F
I
G
L
T
-
I
Y
A
I
Q
R
K
R
Q
A
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------