@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0392: (2015-12-15 )
MILMMENRMPKEIQKTEASEKSIEKVLNAYDKQQHHHQDALAIQYLPAVRAMAFRLKERLPSSIDFNDLVSIGTEELIKLARRYESALNDSFWGYAKTRVNGAMLDYLRSLDVISRSSRKLIKSIDIEITKYLNEHGKEPSDEHLAEALGENIEKIREAKTASDIYALVPIDEQFNAIEQDEITQKIEAEELLEHIQKVLNQMSEREQILIQLYYFEELNLSEIKEILGITESRISQIIKEVIKKVRQSLGVNHG
Atome Classification :
(20 SA)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50........60........70........80........90.....----...100.......110.----------......120.---......130.......140.......150-........160--...--....-.170.....---------.---.180--------..------------.--------.....190--........200.......210...----.----...220--.........230.......240.......250...-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
L
M
MENRM
P
K
E
I
Q
K
TEA
S
E
K
S
I
E
K
V
L
N
A
Y
D
K
Q
Q
H
H
HQ
D
A
L
A
I
Q
Y
L
P
A
V
R
A
M
A
F
R
L
K
E
RLPSSI
D
F
N
D
L
V
S
I
G
T
E
E
L
I
K
L
A
R
R
Y
E
S
ALNDSFWG
Y
A
----
K
TRVN
G
A
M
L
D
Y
L
R
S
L
D
V
----------
I
S
R
S
S
R
K
L
I
K
---
S
I
D
I
E
I
T
K
Y
L
N
EHGKEP
S
D
E
H
L
A
E
A
L
G
E
--
N
I
E
K
I
R
EAKT---AS
D
--
I
Y
A
L
-
V
PI
D
E
Q
FNA---------I---
E
Q
D
---------
E
I
------------
T
--------
Q
KI
E
A
E
E
---
L
L
E
H
I
Q
K
V
L
N
Q
M
S
E
R
E
Q
I
L
I
Q
L
Y
Y
----
F
----EEL
N
----
L
S
E
I
K
E
I
LGI
T
E
S
R
I
S
Q
I
I
K
E
V
I
K
K
V
R
Q
S
LGVNHG-----
1
PsiBlast_PDB
84.77
30%
-74
- C4 -
1RP3
-
?
A:
[3-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Y
S
N
Q
I
E
R
E
E
--
L
I
L
K
Y
L
P
L
V
K
A
I
A
T
N
I
K
K
H
L
P
E
D
V
D
I
R
D
L
I
S
Y
G
V
I
G
L
I
K
A
V
D
N
L
S
T
E
N
P
K
R
A
E
A
Y
I
----
K
L
R
I
K
G
A
I
Y
D
Y
L
R
S
L
D
F
----------
G
S
R
Q
V
R
E
K
E
R
---
R
I
K
E
V
V
E
K
L
K
E
K
L
G
R
E
P
T
D
E
E
V
A
K
E
L
G
I
--
S
T
E
E
L
F
K
T
L
D
---
K
I
N
--
F
S
Y
I
-
L
S
L
E
E
V
F
R
D
---------
F
---
A
R
D
Y
S
E
L
IPSST
N
V
------------
E
--------
E
E
V
I
K
R
E
---
L
T
E
K
V
K
E
A
V
S
K
L
P
E
R
E
K
L
V
I
Q
L
I
F
----
Y
----
E
E
L
P
----
A
K
E
V
A
K
I
L
E
T
S
V
S
R
V
S
Q
L
K
A
K
A
L
E
R
L
R
E
M
L
S
N
--------
22
HHSearch
83.53
30%
-73
- C4 -
1RP3
-
?
A:
[2-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
P
Y
S
N
Q
I
E
R
E
E
L
I
L
K
Y
L
P
L
V
K
A
I
A
T
N
I
K
K
H
L
P
E
D
V
D
I
R
D
L
I
S
Y
G
V
I
G
L
I
K
A
V
D
N
L
S
T
E
N
P
K
R
A
E
A
Y
I
----
K
L
R
I
K
G
A
I
Y
D
Y
L
R
S
L
D
F
----------
G
S
R
Q
V
R
E
K
E
R
---
R
I
K
E
V
V
E
K
L
K
E
K
L
G
R
E
P
T
D
E
E
V
A
K
E
L
G
I
--
S
T
E
E
L
F
K
T
L
D
---
K
I
N
--
F
S
Y
I
-
L
S
L
E
E
V
F
R
D
F
A
R
D
Y
S
E
L
I
P
---
S
S
T
---------
N
V
------------
E
--------
E
E
V
I
K
R
E
---
L
T
E
K
V
K
E
A
V
S
K
L
P
E
R
E
K
L
V
I
Q
L
I
F
----
Y
----
E
E
L
P
----
A
K
E
V
A
K
I
L
E
T
S
V
S
R
V
S
Q
L
K
A
K
A
L
E
R
L
R
E
M
L
S
N
--------
2
PsiBlast_PDB
83.23
30%
-75
- C4 -
1SC5
-
?
A:
[3-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Y
S
N
Q
I
E
R
E
E
--
L
I
L
K
Y
L
P
L
V
K
A
I
A
T
N
I
K
K
H
L
P
E
D
V
D
I
R
D
L
I
S
Y
G
V
I
G
L
I
K
A
V
D
N
L
S
T
E
N
P
K
R
A
E
A
Y
I
----
K
L
R
I
K
G
A
I
Y
D
Y
L
R
S
L
D
F
----------
G
S
R
Q
V
R
E
K
E
R
---
R
I
K
E
V
V
E
K
L
K
E
K
L
G
R
E
P
T
D
E
E
V
A
K
E
L
G
I
--
S
T
E
E
L
F
K
T
L
D
---
K
I
N
--
F
S
Y
I
-
L
S
L
E
E
V
F
R
D
---------
F
---
A
R
D
YSELIPSST------------------------
E
V
I
K
R
E
---
L
T
E
K
V
K
E
A
V
S
K
L
P
E
R
E
K
L
V
I
Q
L
I
F
----
Y
----
E
E
L
P
----
A
K
E
V
A
K
I
L
E
T
S
V
S
R
V
S
Q
L
K
A
K
A
L
E
R
L
R
E
M
L
S
---------
45
Fugue
70.18
21%
-69
- C4 -
4LLG
-
RPOD_ECOLI
F:
[6-612]
QS
Q
L
K
L
L
V
T
R
G
K
EQGYLT
Y
A
E
V
N
D
H
LPEDIVDSD
Q
I
E
D
I
I
Q
M
I
N
D
MGIQVMGRTTDP
V
R
M
Y
M
R
E
M
G
T
V
E
L
L
T
R
E
G
E
I
D
I
A
K
R
I
E
D
G
I
N
Q
V
Q
C
S
V
A
E
Y
P
E
A
I
T
Y
L
L
E
Q
Y
D
R
V
E
A
EEARLSDLITGFVDD
P
E
L
A
R
E
K
F
A
E
L
R
A
Q
Y
V
V
T
R
D
TIKA
T
A
Q
E
E
I
L
K
L
S
E
V
F
K
Q
FRLV
P
K
Q
F
D
Y
L
V
N
S
M
R
V
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
VEQCKMP
K
K
N
F
I
TLFTGNETSDTWFNAAIAMNKPWSEKLHDV
S
E
E
V
H
R
A
L
Q
K
L
Q
Q
I
E
E
E
T
G
L
T
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
T
N
R
---
G
L
Q
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
F
E
Y
R
R
G
Y
K
F
S
T
Y
A
----
T
W
W
I
R
Q
A
I
T
R
S
I
A
D
Q
A
R
T
I
R
-------
I
P
V
H
M
I
E
T
I
N
---
K
L
N
R
I
S
R
Q
M
L
Q
E
M
G
R
E
P
T
P
E
E
L
A
E
R
M
L
M
--
P
E
D
K
I
R
K
V
L
K
---
I
A
K
EP
I
S
M
E
-
T
P
I
G
D
D
E
D
S
---------
H
---
L
G
D
---------
F
I
------------
E
DTTLEL
P
L
D
S
A
T
T
E
S
---
L
R
A
A
T
H
D
V
L
A
G
L
T
A
R
E
A
K
V
L
R
M
R
F
----
G
----
I
D
M
N
TDYT
L
E
E
V
G
K
Q
F
D
V
T
R
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
R
H
P
S
R
S
E
V
L
RSFLD
6
PsiBlast_PDB
68.00
25%
-64
- C4 -
4G7O
2
?
F:
[226-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPS
P
V
D
A
A
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
9
PsiBlast_PDB
67.75
25%
-70
- C4 -
4OIN
3
?
F:
[226-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPS
P
V
D
A
A
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
24
HHSearch
67.65
21%
-72
- C4 -
2A6H
-
?
F:
[171-415]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
Y
L
H
I
A
R
-
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
---
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
----
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
----------
T
I
R
I
P
V
H
M
V
E
TIN
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
GW
D
A
K
R
V
E
E
T
L
K
---
I
A
Q
----
E
P
-
V
S
L
E
T
P
I
G
D
EKDSFYGDF
I
PDE
H
L
P
---------
S
P
------------
V
--------
D
A
A
T
Q
S
L
---
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
----
G
LIDG---------
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
13
PsiBlast_PDB
67.01
25%
-64
- C4 -
4OIR
4
?
F:
[226-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPS
P
V
D
A
A
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
5
PsiBlast_PDB
66.72
25%
-68
- C4 -
4G7H
3
?
F:
[226-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPS
P
V
D
A
A
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
7
PsiBlast_PDB
66.60
25%
-59
- C4 -
4G7Z
2
?
F:
[226-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPS
P
V
D
A
A
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
11
PsiBlast_PDB
66.55
25%
-64
- C4 -
4OIP
3
?
F:
[226-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPS
P
V
D
A
A
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
8
PsiBlast_PDB
66.47
25%
-61
- C4 -
4MQ9
-
?
F:
[226-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPS
P
V
D
A
A
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
10
PsiBlast_PDB
66.43
25%
-67
- C4 -
4OIO
2
?
F:
[226-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPS
P
V
D
A
A
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
12
PsiBlast_PDB
65.96
25%
-62
- C4 -
4OIQ
3
?
F:
[226-429]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
P
V
H
M
V
E
T
I
N
K
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
L
K
I
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPS
P
V
D
A
A
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
3
PsiBlast_PDB
64.54
25%
-61
- C4 -
1L9Z
-
SIGA_THEAQ
H:
[221-424]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
TWWI
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
PVHMVETINK
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
LKI
A
Q
E
--
P
V
S
L
E
T
P
I
------DF-------
I
---
P
D
E
---------
N
L
------------
P
--------
S
P
V
E
A
A
A
QSL
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
23
HHSearch
63.04
22%
-71
- C4 -
1L9Z
-
SIGA_THEAQ
H:
[191-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
E
G
E
A
A
R
Q
H
L
I
E
A
N
L
R
L
V
V
S
I
A
K
K
Y
T
---
G
R
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
----
T
W
W
I
R
Q
A
I
N
R
A
I
A
D
Q
A
R
----------
T
I
R
I
P
V
H
M
V
E
TIN
K
L
S
R
T
A
R
Q
L
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
GW
D
A
K
R
V
E
E
T
L
K
---
I
A
Q
----
E
P
-
V
S
L
E
T
P
I
--DF-------
I
PDE
N
L
P
---------
S
P
------------
V
--------
E
A
A
A
Q
S
L
---
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
----
G
LIDG
R
E
H
T
----
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
4
PsiBlast_PDB
61.74
26%
-56
- C4 -
1L9U
-
SIGA_THEAQ
H:
[115-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
TWWI
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
PVHMVETINK
L
S
R
T
A
R
Q
L
--------------
Q
Q
E
L
G
R
E
P
S
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
LKI
A
Q
E
--
P
V
S
L
E
T
P
I
------DF-------
I
---
P
D
E
---------
N
L
------------
P
--------
S
P
V
E
A
A
A
QSL
L
S
E
E
L
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
----
R
E
H
T
----
L
E
E
V
G
A
Y
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
18
PsiBlast_PDB
60.29
25%
-46
- C4 -
2A69
1
?
F:
[206-409]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
TWWI
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
PVHMVETINK
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
LKI
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPSPVDAA
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
-------------
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
20
PsiBlast_PDB
59.71
25%
-47
- C4 -
2A6H
-
?
F:
[206-409]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
TWWI
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
PVHMVETINK
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
LKI
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPSPVDAA
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
-------------
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----
19
PsiBlast_PDB
58.93
25%
-47
- C4 -
2A6E
-
?
F:
[206-409]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
S
F
L
D
L
I
Q
E
G
N
Q
G
L
I
R
A
V
E
K
F
E
Y
K
R
R
F
K
F
S
T
Y
A
TWWI
R
Q
A
I
N
R
A
I
A
D
Q
A
R
T
I
R
I
PVHMVETINK
L
S
R
T
A
R
Q
L
Q
Q
---
E
L
-----------
G
R
E
P
T
Y
E
E
I
A
E
A
M
G
P
--
G
W
D
A
K
R
V
E
E
T
LKI
A
Q
E
--
P
V
S
L
E
T
P
I
G
D
E
K
D
S
---------
F
---
Y
G
D
---------
F
I
PDEHLPSPVDAA
T
--------
Q
S
L
L
S
E
E
---
L
----
E
K
A
L
S
K
L
S
E
R
E
A
M
V
L
K
L
R
K
GLID
G
-------------
E
E
V
G
A
F
F
G
V
T
R
E
R
I
R
Q
I
E
N
K
A
L
R
K
L
K
Y
H
E
S
R
T
R
K
-----