@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0410: (2015-12-15 )
MQFHSSSALITPFKKDLSVDEAAYETLIKRQIFQGMDACVPVGTTGESATLTHKEHMRCIEIAIETCKSTKTPSNSRMKVLAGVGSNATSESLSLAKFAQKIGADAILCVSPYYNRPTQQGLFEHYKTIAQSVEIPVMLYDVPSRTGVSIEVPTALKLFREVPNIKAIKEASGSLKRVTELHYYEKDFKIFSGEDSLNHSIMFSGGCGVISVTGNLMPNLISQMVNCALKFEYQQALEIQNKLFDLHQALFVETNPIPIKMAMHLAGLIENPSYRLPLVAPSKETIKLLEKTLQQYEVIA
Atome Classification :
(55 SA)
.........10........20........30........40........50........60........70........80........90........100.....-..110.......120.......130.......140.......150.......160.......170.......180--.-..--.....190.......200.......210.......220.......230.......240---.......250--........260.......270.--......280-.........290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQFHSSS
A
L
ITPFKKDLS
V
D
E
A
A
Y
E
T
L
I
K
R
Q
I
F
Q
G
M
D
ACVPVGTTGE
S
A
T
L
T
H
K
E
H
M
R
C
I
E
I
A
I
E
T
C
KSTKTPSNS
R
M
K
V
L
A
GVGSNATSES
L
S
L
A
K
F
A
Q
K
IGA
D
A
I
-
L
C
VSPYYNRP
T
Q
Q
G
L
F
E
H
Y
K
T
I
A
Q
SVEI
P
V
M
L
Y
DVPSRT
G
V
S
I
EV
P
T
A
L
K
L
F
R
EVPN
I
K
A
I
K
E
ASG
S
L
K
R
V
T
E
-
L
--H-
Y
Y
--E
K
D
F
K
I
FSGEDSLN
H
S
I
M
FSGG
C
G
V
I
S
V
T
G
N
L
M
P
N
L
I
S
Q
M
V
N
C
A
L
K
F
E
Y
Q
Q
A
L
E
I
Q
N
K
---
L
F
D
L
H
Q
A
L
F
---VETNP
I
P
I
K
M
A
M
H
L
A
G
L
IENPS--YRLPLVA---P
S
K
E
T
I
K
L
L
E
K
T
L
Q
Q
YEVIA
1
PsiBlast_PDB
96.97
55%
-106
- C5 -
3M5V
6
DAPA_CAMJE
A:
[12-298]
----
A
M
T
A
L
I
T
P
F
K
N
G
-
K
V
D
E
Q
S
Y
A
R
L
I
K
R
Q
I
E
N
G
I
D
A
V
V
P
V
G
T
T
G
E
S
A
T
L
T
H
E
E
H
R
T
C
I
E
I
A
V
E
T
C
K
G
T
K
------
V
K
V
L
A
G
A
G
S
N
A
T
H
E
A
V
G
L
A
K
F
A
K
E
H
G
A
D
G
I
-
L
S
V
A
P
Y
Y
N
K
P
T
Q
Q
G
L
Y
E
H
Y
K
A
I
A
Q
S
V
D
I
P
V
L
L
Y
N
V
P
G
R
T
G
C
E
I
S
T
D
T
I
I
K
L
F
R
D
C
E
N
I
Y
G
V
K
E
A
S
G
N
I
D
K
C
V
D
-
L
--
L
-
A
H
--
E
P
R
M
M
L
I
S
G
E
D
A
I
N
Y
P
I
L
S
N
G
G
K
G
V
I
S
V
T
S
N
L
L
P
D
M
I
S
A
L
T
H
F
A
L
D
E
N
Y
K
E
A
K
K
I
N
D
E
---
L
Y
N
I
N
K
I
L
F
---
C
E
S
N
P
I
P
I
K
T
A
M
Y
L
A
G
L
I
E
S
L
E
--
F
R
L
P
L
C
S
---
P
S
K
E
N
F
A
K
I
E
E
V
M
K
K
Y
K
I
K
G
33
PsiBlast_CBE
91.60
41%
-107
- C5 -
3PUD
6
?
B:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
111
HHSearch
91.30
42%
-101
- C5 -
3TAK
3
?
A:
[1-291]
T
I
Q
G
S
I
V
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
A
-------
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
--
I
-
D
A
L
-
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
-
D
T
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
3
PsiBlast_PDB
91.02
43%
-103
- C5 -
2YXG
-
DAPA_METJA
A:
[8-289]
-------
A
I
I
T
P
F
K
N
K
-
E
V
D
F
D
G
L
E
E
N
I
N
F
L
I
E
N
G
V
S
G
I
V
A
V
G
T
T
G
E
S
P
T
L
S
H
E
E
H
K
K
V
I
E
K
V
V
D
V
V
-------
N
G
R
V
Q
V
I
A
G
A
G
S
N
C
T
E
E
A
I
E
L
S
V
F
A
E
D
V
G
A
D
A
V
-
L
S
I
T
P
Y
Y
N
K
P
T
Q
E
G
L
R
K
H
F
G
K
V
A
E
S
I
N
L
P
I
V
L
Y
N
V
P
S
R
T
A
V
N
L
E
P
K
T
V
K
L
L
A
E
E
Y
S
N
I
S
A
V
K
E
A
N
P
N
L
S
Q
V
S
E
-
L
----
I
H
--
D
A
K
I
T
V
L
S
G
N
D
E
L
T
L
P
I
I
A
L
G
G
K
G
V
I
S
V
V
A
N
I
V
P
K
E
F
V
E
M
V
N
Y
A
L
E
G
D
F
E
K
A
R
E
I
H
Y
K
---
L
F
P
L
M
K
A
M
F
---
I
E
T
N
P
I
P
V
K
T
A
L
N
M
M
G
---
R
P
A
GE
L
R
L
P
L
C
E
---
M
S
E
E
H
K
K
I
L
E
N
V
L
K
D
L
G
L
I
-
7
PsiBlast_PDB
90.87
41%
-110
- C5 -
3RK8
8
?
A:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I
-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
13
PsiBlast_PDB
90.86
41%
-106
- C5 -
4DXV
3
?
A:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I
-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
127
HHSearch
90.58
45%
-99
- C5 -
2YXG
-
DAPA_METJA
A:
[1-289]
M
F
K
G
V
Y
P
A
I
I
T
P
F
K
-
N
K
E
V
D
F
D
G
L
E
E
N
I
N
F
L
I
E
N
G
V
S
G
I
V
A
V
G
T
T
G
E
S
P
T
L
S
H
E
E
H
K
K
V
I
E
K
V
V
D
V
V
-------
N
G
R
V
Q
V
I
A
G
A
G
S
N
C
T
E
E
A
I
E
L
S
V
F
A
E
D
V
G
A
D
A
V
-
L
S
I
T
P
Y
Y
N
K
P
T
Q
E
G
L
R
K
H
F
G
K
V
A
E
S
I
N
L
P
I
V
L
Y
N
V
P
S
R
T
A
V
N
L
E
P
K
T
V
K
L
L
A
E
E
Y
S
N
I
S
A
V
K
E
A
N
P
N
L
S
Q
V
S
E
-
L
--
I
-
H
D
---
A
K
I
T
V
L
S
G
N
D
E
L
T
L
P
I
I
A
L
G
G
K
G
V
I
S
V
V
A
N
I
V
P
K
E
F
V
E
M
V
N
Y
A
L
E
G
D
F
E
K
A
R
E
I
H
Y
K
---
L
F
P
L
M
K
A
M
F
---
I
E
T
N
P
I
P
V
K
T
A
L
N
M
M
G
R
P
-
A
G
E
--
L
R
L
P
L
C
E
---
M
S
E
E
H
K
K
I
L
E
N
V
L
K
D
L
G
L
I
-
10
PsiBlast_PDB
90.55
41%
-106
- C5 -
3TDF
1
?
A:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I
-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
8
PsiBlast_PDB
90.52
41%
-105
- C5 -
3TAK
3
?
A:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I
-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
25
PsiBlast_CBE
90.06
41%
-108
- C5 -
3UQN
2
?
B:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
9
PsiBlast_PDB
90.04
41%
-107
- C5 -
3TCE
2
?
A:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I
-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
36
PsiBlast_CBE
90.03
40%
-105
- C5 -
3QZE
2
DAPA_PSEAE
B:
[27-313]
----
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
-------
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
-
L
P
E
T
V
E
R
L
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
--
E
-
R
V
--
G
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
P
E
-
G
--
I
R
L
P
L
T
W
---
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
V
L
-
15
PsiBlast_PDB
90.00
40%
-107
- C5 -
3QZE
2
DAPA_PSEAE
A:
[27-313]
----
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
-------
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
-
L
P
E
T
V
E
R
L
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
--
E
-
R
V
--
G
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
P
E
-
G
--
I
R
L
P
L
T
W
---
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
V
L
-
23
PsiBlast_CBE
89.95
43%
-109
- C5 -
2EHH
1
DAPA_AQUAE
C:
[8-290]
-------
A
L
I
T
P
F
K
E
G
-
E
V
D
Y
E
A
L
G
N
L
I
E
F
H
V
D
N
G
T
D
A
I
L
V
C
G
T
T
G
E
S
P
T
L
T
F
E
E
H
E
K
V
I
E
F
A
V
K
R
-------
A
A
G
R
I
K
V
I
A
G
T
G
G
N
A
T
H
E
A
V
H
L
T
A
H
A
K
E
V
G
A
D
G
A
-
L
V
V
V
P
Y
Y
N
K
P
T
Q
R
G
L
Y
E
H
F
K
T
V
A
Q
E
V
D
I
P
I
I
I
Y
N
I
P
S
R
T
C
V
E
I
S
V
D
T
M
F
K
L
A
S
E
C
E
N
I
V
A
S
K
E
S
T
P
N
M
D
R
I
S
E
-
I
V-
K
-
R
L
--
G
E
S
F
S
V
L
S
G
D
D
S
L
T
L
P
M
M
A
L
G
A
K
G
V
I
S
V
A
N
N
V
M
P
R
E
V
K
E
L
I
R
A
A
L
E
G
D
F
R
R
A
R
E
I
H
Y
Y
---
L
H
D
L
F
K
V
L
F
---
I
E
T
N
P
I
P
V
K
T
A
C
W
M
L
G
M
C
E
K
-
E
--
F
R
L
P
L
T
E
---
M
S
P
E
N
E
N
K
L
R
E
V
L
K
K
Y
N
L
P
L
11
PsiBlast_PDB
89.75
41%
-107
- C5 -
3U8G
1
?
A:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I
-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
116
HHSearch
89.70
39%
-97
- C5 -
3FLU
13
DAPA_NEIMB
A:
[7-297]
M
L
Q
G
S
L
V
A
L
I
T
P
M
N
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
-------
A
K
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
A
E
K
A
G
A
D
Y
T
-
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
A
-
E
I
P
N
I
V
G
V
K
E
A
S
G
N
I
G
S
N
I
E
-
L
--
I
-
N
R
A-
P
E
G
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
Q
G
D
I
A
L
A
R
E
L
N
D
R
---
L
I
P
I
Y
D
T
M
F
---
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
C
-
E
P
H
--
V
R
L
P
L
V
P
---
L
T
E
N
G
Q
A
K
V
R
A
A
L
K
A
S
G
Q
L
-
30
PsiBlast_CBE
89.66
41%
-107
- C5 -
3RK8
8
?
B:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
122
HHSearch
89.63
41%
-99
- C5 -
3SI9
3
DAPA_BARHE
A:
[22-313]
M
L
K
G
A
V
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
-------
A
K
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
-
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
R
D
F
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
-
Q
--
R
-
E
K
C-
G
K
D
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
---
L
M
P
L
N
R
A
V
F
---
I
E
P
S
P
A
G
I
K
Y
A
A
A
K
L
G
L
C
-
G
T
I
--
V
R
S
P
I
V
P
---
L
S
D
T
T
K
K
I
I
D
E
A
L
Y
H
A
G
L
L
K
35
PsiBlast_CBE
89.58
40%
-107
- C5 -
3QZE
2
DAPA_PSEAE
C:
[27-313]
----
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
E
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
I
Q
V
I
R
R
V
V
D
Q
V
K
G
-------
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
-
L
P
E
T
V
E
R
L
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
--
E
-
R
V
--
G
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
P
E
-
G
--
I
R
L
P
L
T
W
---
L
S
P
R
C
H
E
P
L
R
Q
A
M
R
Q
T
G
V
L
-
29
PsiBlast_CBE
89.52
41%
-107
- C5 -
3TAK
5
?
B:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
32
PsiBlast_CBE
89.10
41%
-108
- C5 -
3PUE
6
?
B:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
28
PsiBlast_CBE
89.10
41%
-106
- C5 -
3TCE
2
?
B:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
31
PsiBlast_CBE
88.46
41%
-108
- C5 -
3PUL
8
?
B:
[8-291]
-------
A
I
V
T
P
M
L
K
D
G
G
V
D
W
K
S
L
E
K
L
V
E
W
H
I
E
Q
G
T
N
S
I
V
A
V
G
T
T
G
E
A
S
T
L
S
M
E
E
H
T
Q
V
I
K
E
I
I
R
V
-------
A
N
K
R
I
P
I
I
A
G
T
G
A
N
S
T
R
E
A
I
E
L
T
K
A
A
K
D
L
G
A
D
A
A
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
L
Y
Q
H
Y
K
A
I
A
E
A
V
E
L
P
L
I
L
Y
N
V
P
G
R
T
G
V
D
L
S
N
D
T
A
V
R
L
A
-
E
I
P
N
I
V
G
I
K
D
A
T
G
D
V
P
R
G
K
A
-
L
I-
D
-
A
L
--
N
G
K
M
A
V
Y
S
G
D
D
E
T
A
W
E
L
M
L
L
G
A
D
G
N
I
S
V
T
A
N
I
A
P
K
A
M
S
E
V
C
A
V
A
I
A
K
D
E
Q
Q
A
K
T
L
N
N
K
---
I
A
N
L
H
N
I
L
F
---
C
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
D
T
-
G
--
I
R
L
P
L
T
P
---
L
A
E
Q
Y
R
E
P
L
R
N
A
L
K
D
A
G
I
I
-
51
PsiBlast_CBE
88.22
40%
-97
- C5 -
3PUO
3
DAPA_PSEAE
B:
[5-292]
----
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
-------
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
-
L
P
E
T
V
E
R
L
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
--
E
-
R
V
--
G
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
P
E
-
G
--
I
R
L
P
L
T
W
---
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
48
PsiBlast_CBE
88.08
39%
-105
- C5 -
3G0S
4
DAPA_SALTY
A:
[32-312]
-------
A
L
V
T
P
M
D
E
K
G
N
V
S
R
S
C
L
K
K
L
I
D
Y
H
V
A
N
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
S
H
D
E
H
G
D
V
V
M
M
T
L
E
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
T
Q
E
G
L
F
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
M
-
L
P
E
T
V
G
R
L
A
E
I
K
N
I
I
A
I
K
E
A
T
G
N
L
T
R
V
H
Q
-
I
K
-
E
-
L
V
--
S
D
D
F
I
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
E
M
A
D
M
C
K
L
A
A
E
G
Q
F
A
E
A
R
A
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
A
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
---
I
T
D
H
G
R
D
I
V
K
A
A
L
Q
H
A
G
L
L
-
47
PsiBlast_CBE
88.07
39%
-105
- C5 -
3G0S
4
DAPA_SALTY
B:
[32-312]
-------
A
L
V
T
P
M
D
E
K
G
N
V
S
R
S
C
L
K
K
L
I
D
Y
H
V
A
N
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
S
H
D
E
H
G
D
V
V
M
M
T
L
E
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
T
Q
E
G
L
F
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
M
-
L
P
E
T
V
G
R
L
A
E
I
K
N
I
I
A
I
K
E
A
T
G
N
L
T
R
V
H
Q
-
I
K
-
E
-
L
V
--
S
D
D
F
I
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
E
M
A
D
M
C
K
L
A
A
E
G
Q
F
A
E
A
R
A
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
A
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
---
I
T
D
H
G
R
D
I
V
K
A
A
L
Q
H
A
G
L
L
-
69
PsiBlast_CBE
87.58
41%
-102
- C5 -
3SI9
3
DAPA_BARHE
A:
[28-307]
------
T
A
L
I
T
P
F
D
D
N
G
A
I
D
E
K
A
F
C
N
F
V
E
W
Q
I
T
Q
G
I
N
G
V
S
P
V
G
T
T
G
E
S
P
T
L
T
H
E
E
H
K
R
I
I
E
L
C
V
E
Q
V
A
K
-------
R
V
P
V
V
A
G
A
G
S
N
S
T
S
E
A
V
E
L
A
K
H
A
E
K
A
G
A
D
A
V
-
L
V
V
T
P
Y
Y
N
R
P
N
Q
R
G
L
Y
T
H
F
S
S
I
A
K
A
I
S
I
P
I
I
I
Y
N
I
P
S
R
S
V
I
D
M
A
V
E
T
M
R
D
L
C
R
D
F
K
N
I
I
G
V
K
D
A
T
G
K
I
E
R
A
S
E
Q
R
--
E
-
K
C
--
G
K
D
F
V
Q
L
S
G
D
D
C
T
A
L
G
F
N
A
H
G
G
V
G
C
I
S
V
S
S
N
V
A
P
K
L
C
A
Q
L
H
A
A
C
L
C
S
D
Y
K
T
A
L
K
L
N
D
L
---
L
M
P
L
N
R
A
V
F
---
I
E
P
S
P
A
G
I
K
Y
A
A
A
K
L
G
L
C
-
G
T
I
--
V
R
S
P
I
V
P
---
L
S
D
T
T
K
K
I
I
D
E
A
L
Y
H
A
G
L
L
K
50
PsiBlast_CBE
86.92
40%
-95
- C5 -
3S8H
1
DAPA_PSEAE
A:
[5-292]
----
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
-------
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
-
L
P
E
T
V
E
R
L
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
--
E
-
R
V
--
G
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
P
E
-
G
--
I
R
L
P
L
T
W
---
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
52
PsiBlast_CBE
86.89
40%
-97
- C5 -
3PUO
4
DAPA_PSEAE
A:
[5-292]
----
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
-------
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
-
L
P
E
T
V
E
R
L
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
--
E
-
R
V
--
G
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
P
E
-
G
--
I
R
L
P
L
T
W
---
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
57
PsiBlast_CBE
86.35
40%
-103
- C5 -
4PFM
6
?
B:
[9-292]
-------
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
---
I
A
V
V
G
Q
T
V
K
F
----
A
S
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
-
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
-
L
P
E
T
I
A
Q
L
V
E
V
P
N
I
I
G
V
-
D
A
T
G
D
V
A
R
V
K
Q
-
L
--
R
D
L
C
--
G
N
D
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
A
G
D
T
Q
A
A
M
A
A
E
D
Q
---
I
K
G
L
F
S
A
L
F
---
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
S
Q
G
D
--
I
R
L
P
L
T
E
---
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
R
I
E
V
61
PsiBlast_CBE
86.21
39%
-104
- C5 -
1YXD
3
DAPA_ECOLI
A:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
-
I
K
-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
IT
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
49
PsiBlast_CBE
86.09
40%
-93
- C5 -
3S8H
1
DAPA_PSEAE
B:
[5-292]
----
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
-------
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
-
L
P
E
T
V
E
R
L
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
--
E
-
R
V
--
G
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
P
E
-
G
--
I
R
L
P
L
T
W
---
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
17
PsiBlast_PDB
86.09
40%
-103
- C5 -
4PFM
5
?
A:
[9-292]
-------
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
---
I
A
V
V
G
Q
T
V
K
F
----
A
S
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
-
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
-
L
P
E
T
I
A
Q
L
V
E
V
P
N
I
I
G
V
-
D
A
T
G
D
V
A
R
V
K
Q
-
L
--
R
D
L
C
--
G
N
D
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
A
G
D
T
Q
A
A
M
A
A
E
D
Q
---
I
K
G
L
F
S
A
L
F
---
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
S
Q
G
D
--
I
R
L
P
L
T
E
---
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
R
I
E
V
58
PsiBlast_CBE
85.72
39%
-106
- C5 -
2ATS
3
DAPA_ECOLI
B:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
-
I
K-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
ITD
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
71
PsiBlast_CBE
85.52
38%
-105
- C5 -
3I7S
10
DAPA_ECOLI
A:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
-
I
K
-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
IT
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
37
PsiBlast_CBE
85.47
41%
-102
- C5 -
4ICN
4
?
B:
[14-297]
-------
A
L
I
T
P
L
N
S
D
G
T
V
D
Y
T
S
L
E
K
L
V
E
Y
H
I
T
E
G
T
D
A
I
V
A
V
G
T
T
G
E
S
A
T
L
P
I
S
E
H
---
I
A
V
V
G
Q
T
V
K
F
----
A
S
G
R
I
P
V
I
G
G
N
G
A
N
A
T
A
E
A
I
E
L
T
K
A
Q
N
K
L
G
V
A
A
M
-
L
G
V
T
P
Y
Y
N
K
P
S
P
K
G
L
I
A
H
Y
T
A
V
A
A
S
T
D
I
P
Q
I
L
Y
N
V
P
G
R
T
A
V
D
M
-
L
P
E
T
I
A
Q
L
V
E
V
P
N
I
I
G
V
K
D
A
T
G
D
V
A
R
V
K
Q
-
L
--
R
D
L
C
--
G
N
D
F
L
L
Y
S
G
D
D
A
T
A
R
E
F
L
T
L
G
G
D
G
V
I
S
V
A
N
N
I
V
P
K
L
F
K
L
M
C
D
A
A
L
A
G
D
T
Q
A
A
M
A
A
E
D
Q
---
I
K
G
L
F
S
A
L
F
---
C
E
A
N
P
I
P
V
K
W
A
A
H
K
M
G
L
I
S
Q
G
D
--
I
R
L
P
L
T
E
---
L
S
T
E
F
H
G
L
L
L
D
A
M
K
N
A
R
I
E
V
94
PsiBlast_CBE
85.35
33%
-102
- C5 -
3DI0
1
DAPA_STAAC
B:
[11-290]
-------
A
L
T
T
P
F
T
N
N
-
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
-------
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
-
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
-
P
E
T
V
E
I
L
S
Q
H
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
-
V
KK
R
-
I
D
--
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
-----
Q
S
G
L
D
I
Q
D
Q
FKP
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
--
L
R
L
P
L
V
S
---
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
G
E
75
PsiBlast_CBE
85.15
38%
-104
- C5 -
3I7Q
7
DAPA_ECOLI
A:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
-
I
K
-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
IT
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
73
PsiBlast_CBE
85.13
38%
-102
- C5 -
3I7R
10
DAPA_ECOLI
A:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
-
I
K
-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
IT
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
56
PsiBlast_CBE
85.12
40%
-94
- C5 -
3NOE
5
DAPA_PSEAE
A:
[5-292]
----
S
M
V
A
L
V
T
P
F
D
A
Q
G
R
L
D
W
D
S
L
A
K
L
V
D
F
H
L
Q
D
G
T
N
A
I
V
A
V
G
T
T
G
E
S
A
T
L
D
V
E
E
H
-------
I
Q
V
V
R
R
V
V
D
Q
V
K
G
R
I
P
V
I
A
G
T
G
A
N
S
T
R
E
A
V
A
L
T
E
A
A
K
S
G
G
A
D
A
C
-
L
L
V
T
P
Y
Y
N
K
P
T
Q
E
G
M
Y
Q
H
F
R
H
I
A
E
A
V
A
I
P
Q
I
L
Y
N
V
P
G
R
T
S
C
D
M
-
L
P
E
T
V
E
R
L
S
K
V
P
N
I
I
G
I
K
E
A
T
G
D
L
Q
R
A
K
E
V
I
--
E
-
R
V
--
G
K
D
F
L
V
Y
S
G
D
D
A
T
A
V
E
L
M
L
L
G
G
K
G
N
I
S
V
T
A
N
V
A
P
R
A
M
S
D
L
C
A
A
A
M
R
G
D
A
A
A
A
R
A
I
N
D
R
---
L
M
P
L
H
K
A
L
F
---
I
E
S
N
P
I
P
V
K
W
A
L
H
E
M
G
L
I
P
E
-
G
--
I
R
L
P
L
T
W
---
L
S
P
H
C
H
D
P
L
R
Q
A
M
R
Q
T
G
V
L
A
99
PsiBlast_CBE
85.05
32%
-102
- C5 -
3DAQ
4
DAPA_STAAR
A:
[10-289]
-------
A
L
T
T
P
F
T
N
N
-
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
-------
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
-
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
-
P
E
T
V
E
I
L
S
Q
H
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
-
V
K
K
R
-
I
D
--
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
-----
Q
S
G
L
D
I
Q
D
Q
F
K
P
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
--
L
R
L
P
L
V
S
---
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
60
PsiBlast_CBE
85.00
39%
-104
- C5 -
1YXD
4
DAPA_ECOLI
B:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
-
I
K-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
ITD
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
95
PsiBlast_CBE
84.93
33%
-103
- C5 -
3DI0
1
DAPA_STAAC
A:
[11-290]
-------
A
L
T
T
P
F
T
N
N
-
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
-------
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
-
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
-
P
E
T
V
E
I
L
S
Q
H
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
-
V
K
K
R
-
I
D
--
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
-----
Q
S
G
L
D
I
Q
D
Q
F
K
P
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
--
L
R
L
P
L
V
S
---
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
G
-
97
PsiBlast_CBE
84.78
32%
-102
- C5 -
3DAQ
5
DAPA_STAAR
C:
[10-289]
-------
A
L
T
T
P
F
T
N
N
-
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
-------
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
-
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
-
P
E
T
V
E
I
L
S
Q
H
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
-
V
KK
R
-
I
D
--
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
-----
Q
S
G
L
D
I
Q
D
Q
FKP
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
--
L
R
L
P
L
V
S
---
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
59
PsiBlast_CBE
84.78
39%
-104
- C5 -
2ATS
3
DAPA_ECOLI
A:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
K
E
A
T
G
N
L
T
R
V
N
Q
-
I
K
-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
IT
D
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
96
PsiBlast_CBE
84.77
32%
-102
- C5 -
3DAQ
4
DAPA_STAAR
D:
[10-289]
-------
A
L
T
T
P
F
T
N
N
-
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
-------
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
-
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
-
P
E
T
V
E
I
L
S
Q
H
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
-
V
KK
R
-
I
D
--
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
-----
Q
S
G
L
D
I
Q
D
Q
FKP
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
--
L
R
L
P
L
V
S
---
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
93
PsiBlast_CBE
84.69
33%
-101
- C5 -
3DI1
1
DAPA_STAAC
A:
[11-290]
-------
A
L
T
T
P
F
T
N
N
-
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
-------
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
-
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
-
P
E
T
V
E
I
L
S
Q
H
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
-
V
K
K
R
-
I
D
--
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
-----
Q
S
G
L
D
I
Q
D
Q
F
K
P
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
--
L
R
L
P
L
V
S
---
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
--
85
PsiBlast_CBE
84.35
40%
-103
- C5 -
3FLU
13
DAPA_NEIMB
A:
[14-277]
-------
A
L
I
T
P
M
N
Q
D
G
S
I
H
Y
E
Q
L
R
D
L
I
D
W
H
I
E
N
G
T
D
G
I
V
A
V
G
T
T
G
E
S
A
T
L
S
V
E
E
H
T
A
V
I
E
A
V
V
K
H
V
A
K
-------
R
V
P
V
I
A
G
T
G
A
N
N
T
V
E
A
I
A
L
S
Q
A
A
E
K
A
G
A
D
Y
T
-
L
S
V
V
P
Y
Y
N
K
P
S
Q
E
G
I
Y
Q
H
F
K
T
I
A
E
A
T
S
I
P
M
I
I
Y
N
V
P
G
R
T
V
V
S
M
T
N
D
T
I
L
R
L
-
A
E
I
P
N
I
V
G
V
K
E
A
S
G
N
I
G
S
N
I
E
-
L
I
-
N
-
R
A
--
P
E
G
F
V
V
L
S
G
D
D
H
T
A
L
P
F
M
L
C
G
G
H
G
V
I
T
V
A
A
N
A
A
P
K
L
F
A
D
M
C
R
A
A
L
Q
G
D
I
A
L
A
R
E
L
N
D
R
---
L
I
P
I
Y
D
T
M
F
---
C
E
P
S
P
A
A
P
K
W
A
V
S
A
L
G
R
C
E
-
P
H
--
V
R
L
P
L
V
P
---
L
T
E
N
G
Q
A
K
V
R
A
A
L
K
A
S
G
Q
L
-
74
PsiBlast_CBE
84.25
38%
-105
- C5 -
3I7Q
7
DAPA_ECOLI
B:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
-
I
K-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
ITD
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
70
PsiBlast_CBE
84.11
38%
-101
- C5 -
3I7S
13
DAPA_ECOLI
B:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
-
I
K-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
ITD
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
98
PsiBlast_CBE
83.47
32%
-102
- C5 -
3DAQ
5
DAPA_STAAR
B:
[10-289]
-------
A
L
T
T
P
F
T
N
N
-
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
-------
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
-
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
-
P
E
T
V
E
I
L
S
Q
H
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
-
V
KK
R
-
I
D
--
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
-----
Q
S
G
L
D
I
Q
D
Q
FKP
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
--
L
R
L
P
L
V
S
---
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
72
PsiBlast_CBE
83.00
38%
-101
- C5 -
3I7R
8
DAPA_ECOLI
B:
[8-283]
-------
A
I
V
T
P
M
D
E
K
G
N
V
C
R
A
S
L
K
K
L
I
D
Y
H
V
A
S
G
T
S
A
I
V
S
V
G
T
T
G
E
S
A
T
L
N
H
D
E
H
A
D
V
V
M
M
T
L
D
L
-------
A
D
G
R
I
P
V
I
A
G
T
G
A
N
A
T
A
E
A
I
S
L
T
Q
R
F
N
D
S
G
I
V
G
C
-
L
T
V
T
P
Y
Y
N
R
P
S
Q
E
G
L
Y
Q
H
F
K
A
I
A
E
H
T
D
L
P
Q
I
L
Y
N
V
P
S
R
T
G
C
D
L
-
L
P
E
T
V
G
R
L
A
K
V
K
N
I
I
G
I
R
E
A
T
G
N
L
T
R
V
N
Q
-
I
K-
E
-
L
V
--
S
D
D
F
V
L
L
S
G
D
D
A
S
A
L
D
F
M
Q
L
G
G
H
G
V
I
S
V
T
A
N
V
A
A
R
D
M
A
Q
M
C
K
L
A
A
E
G
H
F
A
E
A
R
V
I
N
Q
R
---
L
M
P
L
H
N
K
L
F
---
V
E
P
N
P
I
P
V
K
W
A
C
K
E
L
G
L
V
A
T
D
T
--
L
R
L
P
M
T
P
ITD
S
G
R
E
T
V
R
A
A
L
K
H
A
G
L
L
----
132
HHSearch
82.95
33%
-93
- C5 -
3DAQ
4
DAPA_STAAR
A:
[3-290]
L
F
E
G
V
G
V
A
L
T
T
P
F
T
N
-
N
K
V
N
L
E
A
L
K
A
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
L
I
L
K
T
V
I
D
L
V
-------
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
-
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
P
E
T
V
E
I
L
S
-
Q
H
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
-
V
--
K
-
K
R
I
D
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
Q
S
G
L
-----
D
I
Q
D
Q
---
F
K
P
I
G
T
L
L
S
A
L
S
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
G
-
N
Y
E
--
L
R
L
P
L
V
S
---
L
E
D
T
D
T
K
V
L
R
E
A
Y
D
T
F
K
A
G
E
92
PsiBlast_CBE
81.78
33%
-99
- C5 -
3DI1
1
DAPA_STAAC
B:
[11-290]
-------
A
L
T
T
P
F
T
N
N
-
K
V
N
I
E
A
L
K
T
H
V
N
F
L
L
E
N
N
A
Q
A
I
I
V
N
G
T
T
A
E
S
P
T
L
T
T
D
E
K
E
R
I
L
K
T
V
I
D
L
V
-------
D
K
R
V
P
V
I
A
G
T
G
T
N
D
T
E
K
S
I
Q
A
S
I
Q
A
K
A
L
G
A
D
A
I
-
M
L
I
T
P
Y
Y
N
K
T
N
Q
R
G
L
V
K
H
F
E
A
I
A
D
A
V
K
L
P
V
V
L
Y
N
V
P
S
R
T
N
M
T
I
E
-
P
E
T
V
E
I
L
S
Q
H
P
Y
I
V
A
L
K
D
A
T
N
D
F
E
Y
L
E
E
-
V
K
K
R
-
I
D
--
T
N
S
F
A
L
Y
S
G
N
D
D
N
V
V
E
Y
Y
Q
R
G
G
Q
G
V
I
S
V
I
A
N
V
I
P
K
E
F
Q
A
L
Y
D
A
Q
-----
Q
S
G
L
D
I
Q
D
Q
F
K
P
I
G
T
L
L
S
A
L
S
---
V
D
I
N
P
I
P
I
K
A
L
T
S
Y
L
G
F
-
G
N
Y
E
--
L
R
L
P
L
V
S
---
L
E
D
T
D
T
K
V
L
R
E
T
Y
D
T
F
K
A
--
91
PsiBlast_CBE
72.61
31%
-72
- C5 -
3VFL
7
?
A:
[13-291]
------
T
A
F
I
T
P
F
H
E
D
G
S
I
N
F
D
A
I
P
A
L
I
E
H
L
L
A
H
H
T
D
G
I
L
L
A
G
T
T
A
E
S
P
T
L
T
H
D
E
E
L
-------
E
L
F
A
A
V
Q
K
V
V
N
G
R
V
P
L
I
A
G
V
G
T
N
D
T
R
D
S
I
E
F
V
K
E
V
A
E
F
G
G
F
A
A
G
L
A
I
V
P
Y
Y
N
K
P
S
Q
E
G
M
Y
Q
H
F
K
A
I
A
D
A
S
D
L
P
I
I
I
Y
N
I
P
G
R
V
V
V
E
L
T
P
E
T
M
L
R
L
-
A
D
H
P
N
I
I
G
V
K
E
C
T
S
L
A
N
M
A
Y
L
-
I
--
E
-
H
K
--
P
E
E
F
L
I
Y
T
G
E
D
G
D
A
F
H
A
M
N
L
G
A
D
G
V
I
S
V
A
S
H
T
N
G
D
E
M
H
E
M
F
T
A
I
A
E
S
D
M
K
K
A
A
A
I
Q
R
K
---
F
I
P
K
V
N
A
L
F
---
S
Y
P
S
P
A
P
V
K
A
I
L
N
Y
M
G
F
E
A
G
P
T
---
R
L
P
L
V
P
---
A
P
E
E
D
V
K
R
I
I
K
V
V
V
D
G
D
Y
E
A