@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0412: (2015-12-15 )
MLYSLVKKYLFSLDAEIAHEKVCQILRTLSSSPFLCRLIHSQWGYKNPKLENEILGLNFPNPLGLAAGFDKNASMLRALIAFGFGYLEAGTLTNIAQSGNEKPRLFRHIEEESLQNAMGFNNYGAILGVRAFNRFAPYKTPIGINLGKNKHIEQAHALEDYQAVLNQCLNIGDYYTFNLSSPNTPNLRDLQNKVFVNELFCMAKEMTHKPLFLKIAPDLEIDSMLEVVNSAIEAGANGIIATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKSVLVSVGGISDAKEAYERIKMGASLLQIYSAFIYKGPNLCQNILKDLVKLLQKDGFLSVKEAIGADLR
Atome Classification :
(55 SA)
--------.....-....10........20........30...--.....40........50........60........-70........80..-......90.....-...100.......110...----....120..-.--------..---..-------130..------..--------...140--.........150.......160.......170-.......180....-...--------------------190.......200------...------.------------.-------.---------.---210-........220.......230.......240...--....250-.---..--------....260.......270.......280...-....290.......300.......310.......320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------
M
L
Y
S
L
-
V
K
K
Y
L
F
SL
D
A
E
I
A
H
E
K
V
C
Q
I
L
R
T
LSSS
P
F
--
L
C
R
L
I
H
S
QWGYKNPKLEN
E
I
LGLNFPNPLGLAAGF-DK
N
A
S
M
L
R
A
L
I
A
F
G
-
F
G
Y
LEAG
T
L
T
N
I
A
-QSGNEK
P
R
L
F
R
H
I
E
E
E
S
L
Q
----
N
AMGFNN
Y
G
-
A
--------
I
L
---
G
V
-------
R
A
F
NR------FA--------PYKT----P
I
G
I
NLGKNKH
I
E
Q
A
H
A
L
E
D
Y
Q
A
V
L
N
Q
C
LNIG-
D
Y
Y
T
F
NLSSPNTP
N
-
L
R
D
--------------------
L
Q
N
K
V
F
V
N
E
L
F
C
M
------
A
K
E
------M------------T-------H---------K---
P
-
L
-
F
L
K
IAPDL
E
I
D
S
M
L
E
V
V
N
S
A
I
E
AGAN
G
I
I
A
TNTT--IDKS
L
V
F-A---
P
K
--------EMGGLSGKCL
T
K
K
S
R
E
I
F
K
E
L
A
K
A
F
FNK
S
V
-
L
V
S
VGGIS
D
A
K
E
A
Y
E
R
I
K
M
G
A
S
L
L
Q
I
Y
S
A
F
I
YKG
P
N
L
C
Q
N
I
L
K
D
L
V
K
L
L
Q
KDG
F
L
S
V
K
E
A
IGADLR-
55
HHSearch
91.65
42%
-75
- C4 -
1F76
3
PYRD_ECOLI
A:
[1-336]
---------
M
Y
Y
P
F
V
R
K
A
L
F
Q
L
D
P
E
R
A
H
E
F
T
F
Q
Q
L
R
R
I
T
G
T
P
F
--
E
---
A
L
V
-
R
Q
-
K
V
P
A
K
P
V
N
C
M
G
L
T
F
K
N
P
L
G
L
A
A
G
L
-
D
K
D
G
E
C
I
D
A
L
G
A
M
G
-
F
G
S
I
E
I
G
T
V
T
P
R
P
-
Q
P
G
N
D
K
P
R
L
F
R
L
V
D
A
E
G
L
I
----
N
R
M
G
F
N
N
L
G
-
V
--------
D
N
---
L
V
-------
E
N
V
K
K
------
A
---------
H
Y
D
G
----
V
L
G
I
N
I
G
K
N
K
D
T
P
V
E
Q
G
K
D
D
Y
L
I
C
M
E
K
I
Y
A
Y
A
-
G
Y
I
A
I
N
I
S
S
P
N
T
P
G
-
L
R
T
--------------------
L
Q
Y
G
E
A
L
D
D
L
L
T
A
------
I
K
N
------
K
Q
N
D
L
Q
A
M
H
H---
K
-------
Y
---------
V
---
P
-
I
-
A
V
K
I
A
P
D
L
S
E
E
E
L
I
Q
V
A
D
S
L
V
R
H
N
I
D
G
V
I
A
T
N
T
T
--
L
D
R
S
L
V
Q
G
M
KN-
C
D
--------
Q
T
G
G
L
S
G
R
P
L
Q
L
K
S
T
E
I
I
R
R
L
S
L
E
L
N
G
R
L
P
-
I
I
G
V
G
G
I
D
S
V
I
A
A
R
E
K
I
A
A
G
A
S
L
V
Q
I
Y
S
G
F
I
F
K
G
P
P
L
I
K
E
I
V
T
H
I
----------------------
1
PsiBlast_PDB
89.87
41%
-76
- C4 -
1F76
3
PYRD_ECOLI
A:
[3-333]
----------
Y
P
F
-
V
R
K
A
L
F
Q
L
D
P
E
R
A
H
E
F
T
F
Q
Q
L
R
R
I
T
G
T
P
F
EA
L
V
R
-------
Q
K
V
P
A
K
P
V
N
C
M
G
L
T
F
K
N
P
L
G
L
A
A
G
L
-
D
K
D
G
E
C
I
D
A
L
G
A
M
G
-
F
G
S
I
E
I
G
T
V
T
P
R
P
-
Q
P
G
N
D
K
P
R
L
F
R
L
V
D
A
E
G
L
I
----
N
R
M
G
F
N
N
L
G
-
V
--------
D
N
---
L
V
-------
E
N
V
K
K
-------
A
--------
H
Y
D
G
----
V
L
G
I
N
I
G
K
N
K
D
T
P
V
E
Q
G
K
D
D
Y
L
I
C
M
E
K
I
Y
A
Y
A
-
G
Y
I
A
I
N
I
S
S
P
N
T
P
G
-
L
R
T
--------------------
L
Q
Y
G
E
A
L
D
D
L
L
T
A
------
I
K
N
------
K
------------
Q
N
D
L
Q
A
M
H
H
---------
K
Y
V
-
P
-
I
-
A
V
K
I
A
P
D
L
S
E
E
E
L
I
Q
V
A
D
S
L
V
R
H
N
I
D
G
V
I
A
T
N
T
T
--
L
D
R
S
L
V
Q
-
G
---
M
K
NCD-----
Q
T
G
G
L
S
G
R
P
L
Q
L
K
S
T
E
I
I
R
R
L
S
L
E
L
N
G
R
L
P
-
I
I
G
V
G
G
I
D
S
V
I
A
A
R
E
K
I
A
A
G
A
S
L
V
Q
I
Y
S
G
F
I
F
K
G
P
P
L
I
K
E
I
V
T
H
I
----------------------
54
HHSearch
86.32
33%
-77
* C4 *
1TV5
6
PYRD_PLAF7
A:
[40-440]
--------
F
L
Y
D
I
F
L
K
F
C
L
K
Y
I
D
G
E
I
C
H
D
L
F
L
L
L
G
K
Y
----
N
I
--
L
P
--
Y
D
--
T
S
N
D
S
I
Y
A
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
--------
D
K
---
V
T
-------
E
N
L
I
L
------
F
R
K
R
Q
E
E
D
KL
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
--------------------
N
Q
E
A
G
K
L
K
N
I
I
L
S
------
V
K
E
------
E
I
D
N
L
EFLWFNTT
K
-------
K
---------
K
---
P
L
V
-
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
--
T
Q
I
N
D
I
K
S
F
---
E
N
--------
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
-
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
--
27
PsiBlast_CBE
82.50
36%
-65
- C4 -
4JTS
11
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
14
PsiBlast_PDB
81.75
36%
-62
- C4 -
3G0U
3
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
25
PsiBlast_CBE
81.58
36%
-65
- C4 -
4JTU
7
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
37
PsiBlast_CBE
81.56
36%
-62
- C4 -
2FPY
9
PYRD_HUMAN
A:
[78-394]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
35
PsiBlast_CBE
81.56
36%
-64
- C4 -
3U2O
7
PYRD_HUMAN
A:
[78-394]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
26
PsiBlast_CBE
81.56
36%
-64
- C4 -
4JTT
11
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
77
Fugue
81.27
34%
-70
- C4 -
1D3G
6
PYRD_HUMAN
A:
[1-367]
MATGD
E
R
F
Y
A
E
H
L
-
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
F
-------------
Q
D
S
D
M
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
-F
D
K
H
G
E
A
V
D
G
L
Y
K
M
-G
F
G
F
V
E
I
G
S
V
T
P
K
-P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
----Q
A
V
I
N
R
Y
G
F
N
S
H
G
-
L
--------
S
V
---
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
------
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
-A
D
Y
L
V
V
N
V
S
S
P
N
T
A
-G
L
G
K
--------------------
A
E
L
R
R
L
L
T
K
V
L
Q
E
------
R
D
G
------
L
------------
R
-------
R
---------
V
H
R
P
A
-
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
-
S
R
P
A
--------GLQGALRS
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
R
24
PsiBlast_CBE
81.16
36%
-65
- C4 -
4LS0
13
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
30
PsiBlast_CBE
81.11
36%
-64
- C4 -
3W7R
22
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
36
PsiBlast_CBE
81.08
36%
-63
- C4 -
2FQI
8
PYRD_HUMAN
A:
[78-394]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
23
PsiBlast_CBE
80.97
36%
-64
- C4 -
4LS1
8
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
20
PsiBlast_PDB
80.94
36%
-66
- C4 -
3KVK
5
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
13
PsiBlast_PDB
80.89
36%
-63
- C4 -
3FJL
6
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
15
PsiBlast_PDB
80.83
36%
-65
- C4 -
3G0X
4
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
17
PsiBlast_PDB
80.77
36%
-62
- C4 -
3ZWT
8
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
19
PsiBlast_PDB
80.75
36%
-65
- C4 -
3KVJ
6
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
38
PsiBlast_CBE
80.74
36%
-61
- C4 -
2FPV
9
PYRD_HUMAN
A:
[78-394]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
39
PsiBlast_CBE
80.54
36%
-61
- C4 -
2FPT
8
PYRD_HUMAN
A:
[78-394]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
9
PsiBlast_PDB
80.46
36%
-62
- C4 -
2PRL
6
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
11
PsiBlast_PDB
80.36
36%
-61
- C4 -
3F1Q
6
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
16
PsiBlast_PDB
80.35
36%
-62
- C4 -
3ZWS
8
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
33
PsiBlast_CBE
80.34
36%
-60
- C4 -
2B0M
3
PYRD_HUMAN
A:
[76-392]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
22
PsiBlast_CBE
80.27
36%
-63
- C4 -
4LS2
7
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
28
PsiBlast_CBE
80.19
36%
-62
- C4 -
4JS3
14
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
32
PsiBlast_CBE
79.88
36%
-62
- C4 -
3KVL
6
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
5
PsiBlast_PDB
79.86
36%
-66
- C4 -
1D3G
5
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
------------------------
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
31
PsiBlast_CBE
79.74
36%
-65
- C4 -
3KVM
6
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
18
PsiBlast_PDB
79.69
36%
-72
- C4 -
4OQV
9
PYRD_HUMAN
A:
[47-363]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
------------------------------
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
12
PsiBlast_PDB
79.63
36%
-62
- C4 -
3FJ6
6
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
29
PsiBlast_CBE
79.57
36%
-63
- C4 -
4JGD
12
PYRD_HUMAN
A:
[73-389]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
7
PsiBlast_PDB
79.57
36%
-63
- C4 -
2BXV
5
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
------------------------
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
2
PsiBlast_PDB
79.49
38%
-74
- C4 -
1UUM
4
PYRD_RAT
A:
[55-371]
------------------------------------------------------------
L
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
P
Q
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
-
L
--------
S
V
V
E
H
R
L
-------
R
A
R
Q
Q
------
K
Q
--------
A
Q
L
T
A
D
G
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
--
D
Y
A
E
G
V
R
T
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
------------------------------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
------
G
------------
T
-------
R
---------
K
---
P
A
V
-
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
V
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
-
6
PsiBlast_PDB
79.27
36%
-62
- C4 -
1D3H
5
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
34
PsiBlast_CBE
79.13
36%
-59
- C4 -
2WV8
5
PYRD_HUMAN
A:
[48-364]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
21
PsiBlast_CBE
79.09
38%
-74
- C4 -
1UUM
4
PYRD_RAT
B:
[55-371]
------------------------------------------------------------
L
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
P
Q
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
-
L
--------
S
V
VEH
R
L
-------
R
A
R
Q
Q
------
K
Q
--------
A
Q
L
T
ADGL
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
--
D
Y
A
E
G
V
R
T
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
------------------------------
Q
G
K
T
E
L
R
H
L
L
S
K
VLQERD
A
L
K
------
G
------------
T
-------
R
---------
K
---
P
A
V
-
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
V
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
-
3
PsiBlast_PDB
79.02
38%
-70
- C4 -
1UUO
4
PYRD_RAT
A:
[55-371]
------------------------------------------------------------
L
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
P
Q
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
-
L
--------
S
V
V
E
H
R
L
-------
R
A
R
Q
Q
------
K
Q
--------
A
Q
L
T
A
D
G
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
--
D
Y
A
E
G
V
R
T
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
-----------------------------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
------
G
------------
T
-------
R
---------
K
---
P
A
V
-
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
V
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
-
53
PsiBlast_CBE
78.83
31%
-71
- C4 -
1TV5
3
PYRD_PLAF7
A:
[89-437]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
--------------------
N
Q
E
A
G
K
L
K
N
I
I
L
S
------
V
K
E
E
I
D
N
L
E----------------------FLWFNTTKK
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
--
8
PsiBlast_PDB
78.68
36%
-69
- C4 -
2PRH
3
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
------------------------------
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
10
PsiBlast_PDB
77.81
36%
-61
- C4 -
2PRM
2
PYRD_HUMAN
A:
[50-366]
------------------------------------------------------------
L
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
L
S
--------
V
V
---
E
H
-------
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
D
G
L
----
P
L
G
V
N
L
G
K
N
K
--
T
S
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
-
L
R
S
--------------------
L
Q
G
K
A
E
L
R
R
L
L
T
K
------
V
L
Q
E
R
D
G
LR
R
------------
V
-------
H
---------
R
---
P
A
V
-
L
V
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
A
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
G
F
G
G
V
T
D
A
I
G
A
D
H
R
-
4
PsiBlast_PDB
76.97
38%
-66
- C4 -
4ORI
3
PYRD_RAT
A:
[47-363]
------------------------------------------------------------
L
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
P
Q
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
A
V
I
----
N
R
Y
G
F
N
S
H
G
-
L
--------
S
V
V
E
H
R
L
-------
R
A
R
Q
Q
------
K
Q
--------
A
Q
L
T
A
D
G
L
P
L
G
I
N
L
G
K
N
K
T
S
E
D
A
A
A
--
D
Y
A
E
G
V
R
T
L
G
P
L
A
-
D
Y
L
V
V
N
V
S
S
P
N
T
---------------------------
Q
G
K
T
E
L
R
H
L
L
S
K
V
L
Q
E
R
D
A
L
K
------
G
------------
T
-------
R
---------
K
---
P
A
V
-
L
V
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
--
V
S
R
P
V
G
L
-
Q
GAL
R
S
--------
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
-
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
L
K
E
R
G
F
T
T
V
T
D
A
I
G
A
D
H
R
-
50
PsiBlast_CBE
74.87
33%
-72
- C4 -
4CQ9
3
PYRD_PLAF7
A:
[77-395]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
N
-----
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
-
40
PsiBlast_CBE
74.46
33%
-77
- C4 -
3SFK
3
PYRD_PLAF7
A:
[76-394]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
--------NQE
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
N
I
M
N
D
E
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
---
49
PsiBlast_CBE
73.23
33%
-70
- C4 -
4CQ9
3
PYRD_PLAF7
B:
[77-395]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
DKVTENLI
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
NQEAGKLKNIILSVKEEIDN
L
E
K
N
N
-----
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
-
47
PsiBlast_CBE
73.06
33%
-71
- C4 -
4CQA
3
PYRD_PLAF7
B:
[77-395]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
NQE
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
N
-----
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
-
42
PsiBlast_CBE
72.92
33%
-67
- C4 -
3O8A
3
PYRD_PLAF7
A:
[91-409]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
NQE
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
N
I
M
N
D
E
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
---
52
PsiBlast_CBE
72.33
33%
-70
- C4 -
4CQ8
3
PYRD_PLAF7
A:
[77-395]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
N
-----
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
-
51
PsiBlast_CBE
72.21
33%
-67
- C4 -
4CQ8
3
PYRD_PLAF7
B:
[77-395]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
DKVTENLI
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
NQEAGKLKNIILSVKEEIDN
L
E
K
N
N
-----
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
-
48
PsiBlast_CBE
72.07
33%
-71
- C4 -
4CQA
3
PYRD_PLAF7
A:
[77-395]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
NQE
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
N
I
M
N
--
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
-
45
PsiBlast_CBE
71.71
33%
-72
- C4 -
3I65
4
PYRD_PLAF7
A:
[91-409]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
-------E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
--
L
E
K
N
N
I
M
N
D
E
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
S
-
46
PsiBlast_CBE
71.20
33%
-68
- C4 -
4ORM
4
PYRD_PLAF7
A:
[77-395]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
NQE
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
N
I
M
N
D
E
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
---
43
PsiBlast_CBE
70.08
33%
-64
- C4 -
3I6R
3
PYRD_PLAF7
A:
[91-409]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
NQE
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
N
I
M
N
D
E
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
--
44
PsiBlast_CBE
69.62
33%
-64
- C4 -
3I68
3
PYRD_PLAF7
A:
[91-409]
-------------------------------------------------------------------
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
S
I
I
----
N
S
C
G
F
N
N
M
G
-
C
D
K
V
T
E
N
L
I
L
F
---
R
K
-------
R
Q
E
E
D
------
K
L
--------
L
S
K
H
----
I
V
G
V
S
I
G
K
N
K
--
D
T
V
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
-
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
-
L
R
D
NQE
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
N
I
M
N
D
E
F
L
W
------
F
N
T
------
T
------------
K
-------
K
---------
K
---
P
-
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
TQ
I
N
D
I
K
S
F
-
E
---
N
K
--------
K
-
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
-
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
A
V
Q
I
K
R
E
L
N
H
L
L
Y
Q
R
G
Y
Y
N
L
K
E
A
I
G
R
K
H
--