@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0427: (2015-12-15 )
MIKARFKKRLLGSRGAFDLNIDLEIKEAEVVALLGESGAGKSTILRILAGLEAVSSGYIEANHSVWLDTQKKIFLKPQQRKIGFVFQDYALFPHLNVYQNIAFAHPKDKNKIHEVLRLMRLENLSQQKIPKLSGGQAQRVALARALIAAKNLLLLDEPLNALDNALKNEVQQGLLDFIKRENLSVLLVSHDPNEITKLARTFLFLNNGVIDPNQENRLFSNRLLVKPLFEDENYCHYEVIPQTISLPKDCLNPTFKLDFIQNKKF
Atome Classification :
(24 SA)
-....-.-.---.--..10..--......--20........30........40........50........60........70........80........90........100---------..----.-------..-------.-------..---110.......120.-......130.......140.......150.......160.......170.......180.......190.......200.......210--.-....-...220-.---.......230.....--..240-----.......250.......260...---------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
I
K
A
-
R
-
F
---
K
--
K
R
L
LGS--RG
A
F
D
L
--
N
I
D
L
E
I
KE
A
E
V
V
A
L
LGESGA
G
K
S
T
I
L
R
I
L
A
G
L
E
A
V
SSG
Y
I
EAN
H
S
V
W
L
DTQ
K
K
I
F
LKPQQ
R
K
I
G
F
V
FQDYALFPH
L
N
V
Y
Q
NI----------AF----A-------HP-------K-------
D
K
---
N
K
I
H
E
V
L
R
L
M
R
L
E
N
-
L
S
Q
QKIPKLSGG
Q
A
Q
R
V
A
L
A
R
A
L
I
A
AK
N
L
L
L
LD
E
P
L
N
A
L
D
N
A
L
K
N
E
V
Q
Q
G
L
L
D
F
I
K
REN
L
S
V
L
L
V
SH
D
P
N
E
I
T
K
L
A
R
T
F
L
FLNNGVID---P-NQEN-RLFSN--
R
---
L
L
V
K
PLFEDENY
C
H
Y
--
E
VI
P
Q
-----
T
ISL
P
K
D
CLNP
T
F
K
L
D
F
IQNKKF---------------------------------------------------------------------------
124
Fugue
83.07
31%
-101
- C1 -
1OXS
23
?
C:
[1-352]
-
M
V
R
I
-
I
-
V
---
K
NV
S
K
V
F
K
K
--
G
K
V
V
A
L
D-
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
-
D
R
L
V
A
S
N
G
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
----------
A
F
----
P
LTNMKMS
K
E
-------
E
-------
I
R
---
K
R
V
E
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
---
Q
V
G
K
P
E
-
D
L
Y
D
N
PV
S
---
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
--
K
V
T
N
E
GVVIG
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
-
G
I
R
P
E
D
V
KLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK----
123
Fugue
80.84
33%
-102
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
-
E
-
F
V
G
V
E
--
K
I
Y
P
G
G
--
A
R
S
V
R
---
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
------
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
----------
S
F
----
G
-------
L
R
E
K
RVP
K
D
E
-------
M
D
---
A
R
V
R
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
---
Q
-
F
G
T
P
-
E
E
V
Y
E
--
K
PGT
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
--
A
V
Q
N
G
-----
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
--
E
G
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
109
HHSearch
72.80
35%
-113
- C1 -
3RLF
3
MALK_ECOLI
A:
[4-227]
--
V
Q
L
Q
N
-
V
---
T
--
K
A
W
G
E
----
V
V
V
S
K
--
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
------
T
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
----
G
-------
L
K
-------
L
A
GAK
K
E
V
I
N
---
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
L
E
L
Y
H
Y
--
P
---
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
--
F
L
P
V
K
-----
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
---------------------------------------------------------------------------
21
PsiBlast_CBE
72.69
39%
-128
- C1 -
1Z47
1
?
B:
[33-225]
-------------------------------
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
------
D
V
W
I
G
G
K
R
V
T
D
L
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
----------
S
F
----
G
LREKR--
V
P
-------
K
-------
D
E
M
D
-
A
R
V
R
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
---
Q
-
F
G
T
P
-
E
E
V
Y
E
--
K
---
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
--
W
T
R
A
V
-----
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
---------------------------------------------------------------------------
126
Fugue
71.69
26%
-95
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
H
M
I
K
L
-
S
N
I
---
T
--
K
V
F
H
Q
G
--
T
R
T
I
Q
A
LN
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
-
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
----------
A
L
----
P
LELDNTP
K
D
-------
E
-------
V
K
---
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
EQD
T
-
V
S
E
V
-
F
S
H
P
K
--
T
---
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
PE
D
Y
Q
E
R
-----
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
APLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV---------------
11
PsiBlast_PDB
71.59
38%
-128
- C1 -
3PV0
-
MALK_ECOLI
A:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
GLKL
A
-------
G
A
-------
K
-------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
---------------------------------------------------------------------------
19
PsiBlast_PDB
70.87
38%
-133
- C1 -
2D62
7
?
A:
[24-219]
-------------------------------
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
N
L
V
A
D
P
E
K
G
V
F
V
P
P
K
E
R
D
V
A
M
V
F
Q
S
Y
A
L
Y
P
H
M
T
V
Y
D
N
I
----------
A
F
----
P
L
K
L
R
K--
V
P
-------
K
-------
Q
E
I
D
-
K
R
V
R
E
V
A
E
M
L
G
L
T
E
-
L
L
N
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
---
Q
-
V
G
T
P
-
D
E
V
Y
Y
--
K
---
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
--
N
F
L
D
A
-----
T
I
T
D
D
G
F
L
D
F
G
E
F
K
L
K
L
L
Q
D
Q
F
E
---------------------------------------------------------------------------
27
PsiBlast_CBE
70.83
38%
-134
- C1 -
3PUX
5
MALK_ECOLI
B:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
G
L
K
L
A
-------
G
A
-------
K
-------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
---------------------------------------------------------------------------
86
PsiBlast_CBE
70.82
34%
-136
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[22-217]
-------------------------------
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
--
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
----------
A
Y
----
G
LGNGKGR
T
A
-------
Q
-------
E
R
---
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
---
Q
-
T
A
S
P
-
H
E
L
Y
R
--
Q
---
P
A
D
L
D
A
A
L
F
I
G
E
G
I
V
--
F
P
A
A
L
-----
N
A
D
G
T
A
D
C
R
L
G
R
L
P
V
Q
S
G
A
P
A
G
T
---------------------------------------------------------------------------
10
PsiBlast_PDB
70.71
38%
-131
- C1 -
3PUZ
2
MALK_ECOLI
A:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
GLKL
A
-------
G
A
-------
K
-------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
---------------------------------------------------------------------------
13
PsiBlast_PDB
70.65
38%
-131
- C1 -
3PUW
5
MALK_ECOLI
A:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
G
L
K
L
A
-------
G
A
-------
K
-------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
---------------------------------------------------------------------------
12
PsiBlast_PDB
70.56
38%
-130
- C1 -
3PUV
5
MALK_ECOLI
A:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
G
L
K
L
A
-------
G
A
-------
K
-------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
---------------------------------------------------------------------------
25
PsiBlast_CBE
70.55
38%
-132
- C1 -
3PUZ
2
MALK_ECOLI
B:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
GLKL
A
-------
G
A
-------
K
-------
K
E
VIN
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
---------------------------------------------------------------------------
101
HHSearch
70.45
36%
-105
- C1 -
1Z47
1
?
A:
[19-238]
------
G
-
V
---
E
--
K
I
Y
P
G
---
G
A
R
S
V
R
--
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
R
V
T
D
------
L
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
----------
S
F
----
G
-------
L
R
-------
E
K
RVP
K
D
E
M
D
---
A
R
V
R
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
---
Q
-
F
G
T
P
E
E
V
Y
E
K
--
P
---
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
--
T
R
A
V
Q
-----
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
---------------------------------------------------------------------------
18
PsiBlast_PDB
69.86
38%
-129
- C1 -
4KI0
4
?
A:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
G
L
K
L
A
-------
G
A
-------
K
-------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
---------------------------------------------------------------------------
110
HHSearch
69.72
29%
-103
- C1 -
3TUI
1
METN_ECOLI
C:
[24-255]
-
M
I
K
L
S
N
-
I
---
T
--
K
V
F
H
Q
G
TR
T
I
Q
A
L
N
--
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
-
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
----------
A
L
----
P
-------
L
E
-------
L
DNTPKDE
V
K
---
R
R
V
T
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
---
E
-
Q
D
T
V
S
E
V
F
S
H
--
P
---
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
--
D
I
P
E
D
-----
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
---------------------------------------------------------------------------
29
PsiBlast_CBE
69.61
38%
-131
- C1 -
3PUV
5
MALK_ECOLI
B:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
G
L
K
L
A
-------
G
A
-------
K
-------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
---------------------------------------------------------------------------
9
PsiBlast_PDB
69.60
38%
-130
- C1 -
3PUY
3
MALK_ECOLI
A:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
G
L
K
L
A
-------
G
A
-------
K
-------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
---------------------------------------------------------------------------
106
HHSearch
69.48
32%
-115
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-231]
--
L
H
I
G
H
-
L
---
S
--
K
S
F
Q
----
N
T
P
V
L
N
--
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
F
S
K
--
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
----------
A
Y
----
G
-------
L
G
-------
N
GKGRT
A
Q
E
R
---
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
---
Q
-
T
A
S
P
H
E
L
Y
R
Q
--
P
---
A
D
L
D
A
A
L
F
I
G
E
G
I
V
F
--
P
A
A
L
N
-----
A
D
G
T
A
D
C
R
L
G
R
L
P
V
Q
S
G
A
P
A
G
T
R
---------------------------------------------------------------------------
28
PsiBlast_CBE
69.48
38%
-133
- C1 -
3PUW
5
MALK_ECOLI
B:
[21-210]
-------------------------------
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
T
------
P
P
A
E
R
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
----------
S
F
G
L
K
L
A
-------
G
A
-------
K
-------
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
---
Q
-
V
G
K
P
-
L
E
L
Y
H
--
Y
---
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
--
N
F
L
P
V
-----
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
P
---------------------------------------------------------------------------
54
PsiBlast_CBE
64.46
31%
-100
- C1 -
1L2T
4
Y796_METJA
A:
[23-230]
-------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
PLIFKYR
G
A
M
----
S
-------
G
E
-------
E
-------
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
---
R
-
E
E
K
L
-
R
---------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
64.20
31%
-103
- C1 -
3TIF
6
Y796_METJA
B:
[23-232]
-------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
ELPLIFKYRG
A
M
----
S
-------
G
E
-------
E
-------
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
---
R
-
E
E
K
L
-
R
G
F
-------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
63.41
31%
-101
- C1 -
3TIF
7
Y796_METJA
A:
[23-230]
-------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
PLIFKYR
G
A
M
----
S
-------
G
E
-------
E
-------
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
---
R
-
E
E
K
L
-
R
---------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
61.83
31%
-99
- C1 -
1L2T
4
Y796_METJA
B:
[23-232]
-------------------------------
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
D
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
ELPLIFKYRG
A
M
----
S
-------
G
E
-------
E
-------
R
R
---
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
---
R
-
E
E
K
L
-
R
G
F
-------------------------------------------------------------------------------------------------------------------------------------