@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0444: (2015-12-15 )
MGCSFIFKKVRVYSKMLVALGLSSVLIGCAMNPSAETKKPNDAKNQQPVQTHERMTTSSEHVTPLDFNYPVHIVQAPQNHHVVGILMPRIQVSDNLKPYIDKFQDALINQIQTIFEKRGYQVLRFQDEKALNVQDKKKIFSVLDLKGWVGILEDLKMNLKDPNSPNLDTLVDQSSGSVWFNFYEPESNRVVHDFAVEVGTFQAITYTYTSTNNASGGFNSSKSVIHENLDKNREDAIHKILNRMYAVVMKKAVTELTKENIAKYRDAIDRMKGFKSSMPQKK
Atome Classification :
(20 SA)
--------------.........10......---..20........30........40......--..50...-.....60---------........70........-80---------...---.....90...--.....100........110-----------...-....--------------120.----..-....130...-..-..140.......150.......160...-....170..-.....180.......---------190-----------------------.......-.200.......210.......220.....------------------..230.......240.....-..250.......260..-------.......270.......280----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------M
G
C
S
F
I
F
K
K
V
R
V
Y
S
K
M
L
---
V
A
L
G
L
S
S
V
L
I
GCAMNPSAETKKPNDAKNQQ--P
V
Q
T
H
E
R-MTTSSEH---------VTPLDFNY
P
V
H
I
V
QAPQN-H
H
---------
V
V
G
---
I
L
M
P
R
I
Q
VSD--N
L
K
P
Y
I
-
D
K
F
Q
D
A
L
I
N
Q
I
Q
-----------
T
I
F
-
E
KRG--------------
Y
Q
V
L
----
R
F-QDEKAL
N
V
Q
D
-
K
K
-
K
I
F
S
V
LD
L
K
G
W
V
G
I
L
E
D
L
K
M
NLKDPNSP-N
L
D
T
L
V
DQS-SG
S
V
W
F
N
F
YEPES
N
R
---------
V
V
------------------------
H
D
F
A
V
EV-
G
T
F
Q
A
I
T
Y
T
Y
TSTNNASGGFN
S
S
K
S
V
I
H
E
------------------
N
LDK
N
R
E
D
A
I
H
K
I
L
N
R
M
Y
A
V
-
V
M
K
K
A
V
T
E
L
T
K
E
N
--
I
A
-------
K
Y
R
D
A
I
D
R
M
K
G
F
K
SSMPQKK----------------
19
HHSearch
97.12
91%
-110
- C3 -
2I9I
-
?
A:
[51-271]
-----------------------------------------------------------------------
E
R
-
M
K
T
S
S
E
H
---------
V
T
P
L
D
F
N
Y
P
I
H
I
V
Q
A
P
Q
N
-
H
H
---------
V
V
G
---
I
L
T
P
R
I
Q
V
S
D
--
N
L
K
P
Y
I
-
D
K
F
Q
D
A
L
I
N
Q
I
Q
-----------
T
I
F
-
E
K
R
G
--------------
Y
Q
V
L
----
R
F
-
Q
D
E
K
A
L
N
A
Q
D
-
K
R
-
K
I
F
S
V
L
D
L
K
G
W
V
G
I
L
E
D
L
K
M
N
L
K
D
P
N
N
P
-
N
L
D
T
L
V
D
Q
S
-
S
G
S
V
W
F
N
F
Y
E
P
E
S
N
R
---------
V
V
------------------------
H
D
F
A
V
E
V
-
G
T
F
Q
A
M
T
Y
T
Y
K
H
--
N
N
S
G
G
L
N
S
S
N
S
I
I
H
E
------------------
Y
L
E
K
N
K
E
D
A
I
H
K
I
L
N
R
M
Y
A
V
-
V
M
K
K
A
V
T
E
L
T
K
E
N
--
I
D
-------
K
Y
R
E
A
I
D
R
M
K
G
F
K
-----------------------
29
Fugue
96.83
91%
-111
- C3 -
2I9I
-
?
A:
[51-271]
-----------------------------------------------------------------------
E
R
-
M
K
T
S
S
E
H
---------
V
T
P
L
D
F
N
Y
P
I
H
I
V
Q
A
P
Q
N
-
H
H
---------
V
V
G
---
I
L
T
P
R
I
Q
V
S
D
--
N
L
K
P
Y
I
-
D
K
F
Q
D
A
L
I
N
Q
I
Q
-----------
T
I
F
-
E
K
R
G
--------------
Y
Q
V
L
----
R
F
-
Q
D
E
K
A
L
N
A
Q
D
-
K
R
-
K
I
F
S
V
L
D
L
K
G
W
V
G
I
L
E
D
L
K
M
N
L
K
D
P
N
N
P
-
N
L
D
T
L
V
D
Q
S
-
S
G
S
V
W
F
N
F
Y
E
P
E
S
N
R
---------
V
V
------------------------
H
D
F
A
V
E
V
-
G
T
F
Q
A
M
T
Y
T
Y
K
H
N
N
--
S
G
G
L
N
S
S
N
S
I
I
H
E
------------------
Y
L
E
K
N
K
E
D
A
I
H
K
I
L
N
R
M
Y
A
V
-
V
M
K
K
A
V
T
E
L
T
K
E
N
--
I
D
-------
K
Y
R
E
A
I
D
R
M
K
G
F
K
-----------------------
1
PsiBlast_PDB
96.61
90%
-111
- C3 -
2I9I
-
?
A:
[51-271]
-----------------------------------------------------------------------
E
R
-
M
K
T
S
S
E
H
---------
V
T
P
L
D
F
N
Y
P
I
H
I
V
Q
A
P
Q
N
-
H
H
---------
V
V
G
---
I
L
T
P
R
I
Q
V
S
D
--
N
L
K
P
Y
I
-
D
K
F
Q
D
A
L
I
N
Q
I
Q
-----------
T
I
F
-
E
K
R
G
--------------
Y
Q
V
L
----
R
F
-
Q
D
E
K
A
L
N
A
Q
D
-
K
R
-
K
I
F
S
V
L
D
L
K
G
W
V
G
I
L
E
D
L
K
M
N
L
K
D
P
N
N
P
-
N
L
D
T
L
V
D
Q
S
-
S
G
S
V
W
F
N
F
Y
E
P
E
S
N
R
---------
V
V
------------------------
H
D
F
A
V
E
V
-
G
T
F
Q
A
M
T
Y
T
Y
K
H
N
N
--
S
G
G
L
N
S
S
N
S
I
I
H
E
------------------
Y
L
E
K
N
K
E
D
A
I
H
K
I
L
N
R
M
Y
A
V
-
V
M
K
K
A
V
T
E
L
T
K
E
N
--
I
D
-------
K
Y
R
E
A
I
D
R
M
K
G
F
K
-----------------------
5
PsiBlast_PDB
47.84
34%
-68
- C3 -
1WVF
3
DH4C_PSEPU
A:
[421-483]
-----------------------------------------------------------------------------------------------
L
D
Y
V
A
E
F
I
V
A
P
R
D
M
H
H
---------
V
I
D
---
V
L
Y
------
D
--
R
T
N
P
E
E
-
T
K
R
A
D
A
C
F
N
E
L
L
-----------
D
E
F
-
E
K
E
G
--------------
Y
A
V
Y
RVNT
R
F
-
Q
D
R
V
A
Q
S
Y
G
P
-
V
K
-
R
K
L
E
H
A
I
K
R
A
V
D
P
N
N
I
L
A
P
G
R
S
G
I
D
L
N
N
-
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_CBE
46.77
34%
-65
- C3 -
1WVE
4
DH4C_PSEPU
B:
[421-483]
-----------------------------------------------------------------------------------------------
L
D
Y
V
A
E
F
I
V
A
P
R
D
M
H
H
---------
V
I
D
---
V
L
Y
------
D
--
R
T
N
P
E
E
-
T
K
R
A
D
A
C
F
N
E
L
L
-----------
D
E
F
-
E
K
E
G
--------------
Y
A
V
Y
RVNT
R
F
-
Q
D
R
V
A
Q
S
Y
G
P
-
V
K
-
R
K
L
E
H
A
I
K
R
A
V
D
P
N
N
I
L
A
P
G
R
S
G
I
D
L
N
N
-
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
46.75
34%
-66
- C3 -
1WVE
5
DH4C_PSEPU
A:
[421-483]
-----------------------------------------------------------------------------------------------
L
D
Y
V
A
E
F
I
V
A
P
R
D
M
H
H
---------
V
I
D
---
V
L
Y
------
D
--
R
T
N
P
E
E
-
T
K
R
A
D
A
C
F
N
E
L
L
-----------
D
E
F
-
E
K
E
G
--------------
Y
A
V
Y
RVNT
R
F
-
Q
D
R
V
A
Q
S
Y
G
P
-
V
K
-
R
K
L
E
H
A
I
K
R
A
V
D
P
N
N
I
L
A
P
G
R
S
G
I
D
L
N
N
-
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_CBE
46.54
34%
-70
- C3 -
1DIQ
2
DH4C_PSEPU
B:
[422-484]
-----------------------------------------------------------------------------------------------
L
D
Y
V
A
E
F
I
V
A
P
R
D
M
H
H
---------
V
I
D
---
V
L
Y
------
D
--
R
T
N
P
E
E
-
T
K
R
A
D
A
C
F
N
E
L
L
-----------
D
E
F
-
E
K
E
G
--------------
Y
A
V
Y
RVNT
R
F
-
Q
D
R
V
A
Q
S
Y
G
P
-
V
K
-
R
K
L
E
H
A
I
K
R
A
V
D
P
N
N
I
L
A
P
G
R
S
G
I
D
L
N
N
-
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
46.53
21%
-23
- C3 -
4QT4
-
PTH_STRPZ
A:
[1-189]
--------------------------
M
V
K
M
I
---
V
G
L
G
----------
N
P
G
S
K
Y
E
K
---
T
K
H
N
I
--
G
F
M
A
I
D
N
-
I
V
K
N
L
D
V
---------
T
F
T
D
D
K
N
F
K
A
Q
I
G
S
T
F
I
N
-
H
E
---------
K
V
Y
---
F
V
K
P
T
-------------------------------------
T
F
M
-
N
N
S
G
--------------
I
A
V
K
----
A
L
-
L
T
Y
Y
N
I
D
I
T
D
--------------
L
I
V
I
Y
D
D
L
D
M
E
V
---------
S
K
L
R
L
R
S
-
K
G
S
-------
A
G
G
H
N
---------
G
I
------------------------
K
S
I
I
A
H
I
-
G
T
Q
E
F
N
R
I
K
V
G
I
G
R
P
L
K
G
-----
M
T
V
I
N
H
------------------
V
M
G
Q
F
N
T
E
D
N
I
A
I
S
L
T
L
D
R
V
-
V
--
N
A
V
K
F
Y
L
Q
E
N
-----------
D
F
E
K
T
M
Q
K
F
N
G
-------------------------
3
PsiBlast_PDB
46.30
34%
-71
- C3 -
1DIQ
2
DH4C_PSEPU
A:
[422-484]
-----------------------------------------------------------------------------------------------
L
D
Y
V
A
E
F
I
V
A
P
R
D
M
H
H
---------
V
I
D
---
V
L
Y
------
D
--
R
T
N
P
E
E
-
T
K
R
A
D
A
C
F
N
E
L
L
-----------
D
E
F
-
E
K
E
G
--------------
Y
A
V
Y
RVNT
R
F
-
Q
D
R
V
A
Q
S
Y
G
P
-
V
K
-
R
K
L
E
H
A
I
K
R
A
V
D
P
N
N
I
L
A
P
G
R
S
G
I
D
L
N
N
-
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
46.27
34%
-68
- C3 -
1DII
1
DH4C_PSEPU
A:
[422-484]
-----------------------------------------------------------------------------------------------
L
D
Y
V
A
E
F
I
V
A
P
R
D
M
H
H
---------
V
I
D
---
V
L
Y
------
D
--
R
T
N
P
E
E
-
T
K
R
A
D
A
C
F
N
E
L
L
-----------
D
E
F
-
E
K
E
G
--------------
Y
A
V
Y
RVNT
R
F
-
Q
D
R
V
A
Q
S
Y
G
P
-
V
K
-
R
K
L
E
H
A
I
K
R
A
V
D
P
N
N
I
L
A
P
G
R
S
G
I
D
L
N
N
-
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_CBE
45.40
34%
-64
- C3 -
1DII
1
DH4C_PSEPU
B:
[422-484]
-----------------------------------------------------------------------------------------------
L
D
Y
V
A
E
F
I
V
A
P
R
D
M
H
H
---------
V
I
D
---
V
L
Y
------
D
--
R
T
N
P
E
E
-
T
K
R
A
D
A
C
F
N
E
L
L
-----------
D
E
F
-
E
K
E
G
--------------
Y
A
V
Y
RVNT
R
F
-
Q
D
R
V
A
Q
S
Y
G
P
-
V
K
-
R
K
L
E
H
A
I
K
R
A
V
D
P
N
N
I
L
A
P
G
R
S
G
I
D
L
N
N
-
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
41.54
14%
-9
- C1 -
3PT5
-
?
A:
[4-326]
---------------------
I
I
S
P
D
Y
Y
Y
V
L
---
T
V
A
G
Q
S
N
A
M
A
Y
G
E
G
L
P
L
P
D
R
E
D
A
P
H
P
R
I
K
Q
L
A
R
F
A
H
T
H
P
-
G
G
P
S
C
H
F
---------
N
D
I
I
P
L
T
H
C
P
H
D
V
Q
D
M
Q
S
-
Y
H
HPLATNHQT
Q
Y
G
---
T
V
G
Q
A
L
H
I
A
R
--
K
L
L
P
F
I
P
D
N
A
G
I
L
I
V
P
C
C
R
G
GSAFTAGSE
G
T
Y
S
-
E
R
H
G
ASHDACRWGTDT
P
L
Y
Q
D
L
----
V
S
-
R
T
R
A
A
L
V
K
N
P
-
Q
N
-
K
F
L
G
V
C
W
M
Q
G
E
--------
F
D
L
M
T
S
D
Y
A
-
S
H
P
Q
H
F
N
H
M
-
V
E
A
F
R
R
D
L
K
Q
Y
H
S
Q
L
NDAPWF
C
G
D
T
T
------------------------
W
Y
W
K
E
N
F
-
P
H
A
Y
E
A
I
Y
G
N
Y
Q
N
N
I
L
A
N
I
I
F
V
D
F
Q
Q
Q
G
A
------------------
R
G
L
T
N
A
P
D
E
D
P
D
D
L
S
T
G
Y
Y
G
-
S
A
Y
R
S
P
E
N
W
T
T
A
L
--
R
S
SHFS
S
A
A
R
R
G
I
I
S
D
R
F
V
E
A
I
L
Q
F
W
R
E
R
----------------
32
Fugue
39.94
28%
-23
- C3 -
2D7D
-
?
B:
[1-38]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
R
Q
K
V
V
E
Q
M
-
E
H
-
E
M
K
E
A
A
K
A
L
D
F
E
R
--
A
A
-------
E
L
R
D
L
L
L
E
L
K
A
-------------------------
24
HHSearch
34.32
15%
15
- C3 -
2QUP
1
?
A:
[24-76]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
F
S
E
V
M
---
G
K
------------------
Q
R
D
E
K
A
Y
E
R
L
Q
A
L
M
S
K
I
D
D
Q
--
G
K
L
L
S
E
T
R
T
I
E
E
--
L
R
-------
K
Y
K
E
L
V
K
E
F
V
G
D
A
V
E
L
G
L
R
L
----------------
25
HHSearch
33.86
17%
8
- C3 -
2P61
-
?
A:
[44-84]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
H
F
E
K
L
L
E
E
A
V
E
E
V
I
D
S
-
G
-
N
E
L
V
R
S
P
T
P
S
N
--
L
K
-------
R
Y
K
N
A
I
K
E
F
L
K
L
I
E
K
K
I
Y
K
L
----------------
7
PsiBlast_PDB
33.21
26%
-13
- C4 -
4NPM
2
ALKB5_DANRE
A:
[159-224]
--------------
F
G
C
K
F
L
F
K
P
I
R
V
S
E
P
V
L
H
L
P
V
R
R
G
S
V
T
V
L
S
G
Y
A
A
D
D
I
T
H
C
I
R
P
Q
D
I
K
E
R
R
--
A
V
I
I
L
R
K
-
T
R
A
D
A
P
R
------------
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
33.09
9%
-19
- C2 -
3DTY
1
?
A:
[7-398]
RRIPQPIR
W
A
M
V
G
G
G
S
Q
S
Q
I
G
Y
I
H
R
C
A
A
L
R
D
---
N
T
F
V
L
V
A
G
A
F
D
I
D
P
I
R
G
S
A
F
G
E
Q
L
G
V
D
S
E
R
--
C
Y
A
D
Y
L
S
M
F
E
Q
E
A
R
R
ADGIQ
A
V
S
I
A
T
P
N
G
T
H
Y
S
I
T
K
A
A
L
E
A
G
-
L
H
---------
V
V
C
EKP
L
C
F
T
V
E
Q
A
E
N
--
L
R
E
L
S
H
-
K
H
N
R
I
V
G
V
T
Y
G
Y
-----------
A
G
H
---
Q
L
--------------
I
E
Q
A
----
R
E
M
I
A
A
G
E
L
G
D
V
R
M
V
H
M
Q
F
A
H
G
F
H
S
A
G
P
S
Y
V
L
G
D
V
G
T
H
P
L
Y
L
S
E
V
M
L
P
D
L
K
I
K
R
L
M
C
S
R
Q
S
F
V
A
S
R
A
P
L
E
D
---------
N
A
Y
T
L
M
E
Y
EGG
A
M
G
M
V
W
S
S
AVNAGSM
H
G
Q
K
I
R
V
I
G
S
R
A
S
L
E
W
W
D
E
R
P
N
Q
L
S
F
E
V
Q
G
Q
P
A
Q
I
L
E
R
GMGYLHPNALIDDRIGG
G
H
P
E
G
L
F
E
A
W
A
N
L
Y
Y
R
F
A
L
A
M
D
A
T
D
R
S
D
T
Q
A
L
S
A
VR
Y
P
-------
G
I
D
A
G
V
E
G
V
R
W
V
E
R
C
V
L
S
A
D
N
DSIWVAYEGHHHHHH
6
PsiBlast_PDB
32.36
26%
-16
- C4 -
4NPL
2
ALKB5_DANRE
A:
[159-225]
--------------
F
G
C
K
F
L
F
K
P
I
R
V
S
E
P
V
L
H
L
P
V
R
R
G
S
V
T
V
L
S
G
Y
A
A
D
D
I
T
H
C
I
R
P
Q
D
I
K
E
R
R
--
A
V
I
I
L
R
K
-
T
R
A
D
A
P
R
------------
L
D
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
30.27
19%
13
- C3 -
3B4Q
1
?
A:
[4-93]
--------------------------------------------------
L
N
S
A
P
T
P
R
D
V
V
A
N
A
--
P
A
P
V
Q
A
A
-
V
A
G
A
Q
E
Y
---------
A
A
Q
A
G
L
N
---------
T
E
-
E
L
---------
A
V
D
---
A
L
Y
N
A
I
K
V
R
L
A
G
G
I
P
P
Q
I
-
E
A
F
Y
Q
A
N
R
T
N
F
N
-----------
G
F
Y
M
A
N
R
G
--------------
A
I
D
F
----
I
F
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
29.77
34%
8
- C4 -
4O61
10
ALKB5_HUMAN
A:
[156-207]
--------------
F
G
C
K
F
Q
F
K
P
I
R
V
S
E
P
V
L
S
L
P
V
R
R
G
S
V
T
V
L
S
G
Y
A
A
D
E
I
T
H
C
I
R
P
Q
D
I
K
E
R
R
--
A
V
I
I
L
R
K
-
T
R
L
D
A
P
R
---------
L
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------