@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0458: (2015-12-15 )
MLRLLIGLLLMSFISLQSASWQEPLRVSIEFVDLPKKIIRFPAHDLKVGEFGFVVTKLSDYEIVNSEVVIIAVENGVATAKFKAFESMKQSHLPTPRMVAKKGDLVYFRQFNNQAFLIAPNDELYEQIRATNTDINFISSDLLVTFLNGFDPKIANLRKACNVYSVGVIYIVTTNTLNILSCESFEILEKRELDTSGVTKTSTPFFSRVEGIDAGTLGKLFSGSQSKNYFAYYDALVKKEKRKEVRIEKKEERIDARENKREIKQEAIKEPKKANQGTENAPTLEEKNYQKAERKFDAKEERRRSRDERKKTKATKKAMEFEEREKEHDERDEKETEERRKALEMDKGNEKVNAKENEREINQESANEPSSENNATLKDTENTSVLKESAAKKEAPKPSSKEEKRRLKEEKKKAKAEQRAREFEQRAREHQERDEKELEERRKALEMNKK
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50.....-...60........70........80........90........100.......110--.......120.......130.......140.....-..150........160.......170-.......180.......190.......200.......210.......220.......230.......240-........250.......260.......270.-......280.......290.......300.---....---..310.......320.......330......-.340..---.--------....350......--------.360-----------...-.....370.......380.......390.-...-...400.......-------------410..--...-..420.......430.....---..440.......450-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
L
L
I
G
L
L
L
M
S
F
I
S
LQSASWQE
P
L
R
V
S
I
E
F
VDL
P
K
K
I
I
RFPAHDLKVG
E
F
G
F
V
V
T
-KLSD
Y
E
I
VNS
E
V
V
I
I
A
VENGVA
T
A
K
F
K
A
F
E
S
M
K
Q
SHLPT
P
R
M
VAKKG
D
L
V
Y
F
R
QFN--N
Q
A
F
L
IAP
N
D
E
L
Y
E
Q
I
RATNTDIN
F
I
S
S
D
L
L
V
T
F
L
-NGFD-
P
K
I
A
N
L
R
K
A
CN
V
Y
S
V
G
V
I
Y
I
V
-TTN
T
L
N
I
LSCE
S
F
E
I
L
E
K
RELDTSGVTKTSTP
F
F
S
R
VEGIDAG
T
L
G
K
L
FSGSQSKN
Y
F
A
Y
Y
D
A
L
V
K
K
E
K
--
R
K
E
V
R
I
E
K
K
E
E
R
I
D
A
R
E
N
K
R
E
I
K
Q
E
A
I
KE
P
K
K-ANQGTENAPTL
E
E
K
N
Y
Q
K
A
E
R
KF
D
A
K
E
E
R
R
---
R
S
R
D
---
E
R
K
K
T
K
A
T
K
K
A
M
E
F
E
E
R
E
K
EHDER
D
E
K
E
T
E
E
-
R
R
K
A
LE---M--------DKGNEKVNA
K
E
N
E
--------
R
EI------------NQE-SANEPSSENN
A
T
LKDTE
N
T
S
V
L
K
E
S
AAKK-EAP-KPS
S
K
E
E
K
R
R
L
K
E
-------------
E
K
K
K
A
--
K
A
E
-
Q
R
A
R
E
F
E
Q
R
A
R
E
H
Q
E
R
D
E
K
E
---
L
E
E
R
R
K
A
LEMNKK-------
13
PsiBlast_PDB
70.58
24%
96
- C4 -
4F61
-
?
I:
[55-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
R
--
R
K
Y
Q
E
A
E
L
L
K
H
L
A
E
K
R
E
H
E
R
E
V
I
Q
R
A
I
E
E
N
N
N
W
I
K
M
A
K
E
K
L
A
Q
K
M
E
S
N
K
E
N
R
E
A
H
F
A
A
M
L
E
R
L
---
Q
E
K
D
KHA
E
E
V
R
Q
R
A
I
E
E
N
N
N
W
I
K
M
A
K
E
K
L
A
Q
K
M
E
S
N
K
E
-
N
R
K
Y
Q
E
---
A
--------
E
L
L
K
H
L
A
E
K
R
E
H
E
--------
R
E
V
------------
I
Q
R
-
A
I
----
E
E
N
N
N
W
I
K
-
M
A
K
E
K
L
A
Q
K
M
E
S
N
K
-
E
N
R
-
E
A
H
F
A
A
M
L
E
R
L
Q
E
-------------
K
D
K
H
A
--
E
E
V
-
R
K
N
K
E
L
K
E
-----------------------------------
27
Fugue
67.65
15%
4
- C4 -
2DFS
-
MYO5A_CHICK
A:
[5-1080]
ELYTKY
A
R
V
W
I
P
D
PEEV
W
K
S
A
E
L
LKDYKPGDK
V
L
Q
L
R
L
EE
G
K
D
L
E
Y
C
L
DPKTKEL
P
P
L
R
N
P
DILVGENDLTALSYLH
E
P
A
V
L
H
N
L
K
V
R
F
IDSKLIYTYCGI
V
L
V
A
I
N
PYEQLPIYG
E
D
I
I
N
A
Y
SGQNMGDMDPH
I
F
A
V
A
E
E
A
Y
K
Q
M
A
R
D
E
R
N
Q
S
I
I
V
S
G
E
S
GAG
K
T
V
S
A
K
Y
A
M
R
Y
F
A
T
V
S
GSASEAN
V
E
E
K
V
L
A
S
N
P
I
M
E
S
I
G
N
A
K
T
TRNDNSSR
F
G
K
Y
I
E
I
G
F
D
KR
Y
R
I
I
G
A
N
M
R
T
Y
LLE
K
S
R
V
V
F
QAEEERNY
H
I
F
Y
Q
L
C
A
S
AALPEFKTLRLGNANYFHYTKQGGSPVIDGID
D
A
K
E
M
V
N
T
R
Q
A
C
T
L
L
GIS
D
S
Y
Q
M
G
I
F
R
I
L
A
G
I
L
H
L
G
N
V
E
F
A
S
R
D
SD
S
C
A
I
P
P
KH
D
P
L
T
I
F
C
D
L
M
GVD
Y
E
E
M
A
H
W
L
C
H
RKLAT
Y
I
K
P
I
S
K
L
H
A
I
N
A
R
D
A
L
A
K
H
I
Y
A
N
L
F
N
W
I
V
D
H
V
N
K
A
L
HSTVKQH
S
F
I
G
V
L
D
I
Y
G
FETFEINS
F
E
Q
F
C
I
N
Y
A
N
E
K
L
Q
Q
Q
F
N
M
H
V
F
K
L
E
Q
E
E
Y
M
K
E
QIPWTL
I
D
F
Y
D
N
Q
P
C
I
N
L
I
EAKMG
V
L
D
L
L
D
E
E
C
K
MPKGS
D
D
T
W
A
Q
K
L
Y
N
T
HLNKCAL
F
E
K
P
RLSNK
A
F
I
I
KHFA
D
K
V
E
Y
Q
CEG
F
L
E
K
N
K
D
T
V
Y
E
E
Q
I
K
V
L
K
S
S
K
K
F
K
L
L
P
E
L
F
Q
H
K
K
T
----------
V
G
H
Q
F
R
N
S
L
H
L
L
M
E
T
L
N
A
T
T
P
H
Y
V
R
C
I
K
P
N
D
F
K
F
P
F
T
------
F
D
E
K
R
A
V
Q
Q
L
R
A
C
G
V
L
E
T
I
R
I
S
A
A
G
F
P
S
R
W
T
Y
Q
E
F
F
S
R
Y
R
--
V
---
L
M
K
Q
K
D
V
L
---------------
S
D
R
K
Q
T
C
K
-
N
V
L
E
-
K
L
I
L
D
K
D
K
----
Y
Q
F
G
K
T
K
I
F
F
R
A
G
Q
V
A
Y
L
E
K
I
R
A
D
K
L
R
A
A
C
I
R
I
Q
K
T
I
R
G
W
L
M
R
K
K
Y
M
R
M
R
R
A
A
I
T
I
Q
R
Y
V
R
G
H
Q
A
R
C
Y
A
T
F
L
R
R
T
R
A
A
I
I
I
Q
K
F
Q
R
M
Y
V
V
R
K
R
Y
Q
C
M
R
D
A
T
I
A
L
Q
A
L
L
R
G
Y
L
V
-
R
N
K
Y
Q
M
M
L
R
E
H
K
S
I
I
I
Q
K
H
V
R
G
W
L
A
R
V
H
Y
H
---
R
T
L
K
---
A
I
V
Y
L
Q
C
C
Y
R
R
M
M
A
K
R
E
L
K
K
L
M
N
N
L
E
I
T
Y
S
T
-
E
T
E
K
L
R
---
S
--------
D
V
E
R
L
R
M
S
E
E
E
A
K
--------
N
A
T
------------
N
R
V
L
S
L
Q
E
E
I
A
K
L
R
K
E
L
H
Q
T
Q
T
E
K
K
T
I
E
E
W
A
D
K
-
Y
K
H
-
E
T
E
Q
L
V
S
E
L
K
E
Q
N
-------------
T
L
L
K
T
--
E
K
E
-
E
L
N
R
R
I
H
D
Q
A
K
E
I
T
E
T
M
E
K
K
---
L
V
E
E
T
K
Q
L
E
L
D
L
N
D
E
R
L
R
Y
Q
31
Fugue
58.66
15%
74
- C4 -
4GKW
-
SAS6_CAEEL
A:
[250-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
K
E
D
E
V
A
D
L
K
Q
D
T
E
S
L
Q
K
---
Q
L
E
E
---
N
Q
E
E
L
E
I
V
G
N
M
L
R
E
E
Q
G
K
V
D
Q
L
Q
K
R
N
V
A
H
Q
K
-
E
I
G
K
L
R
---
A
--------
E
L
G
T
A
Q
R
N
L
E
K
A
D
--------
Q
L
L
------------
K
R
N
-
S
Q
Q
Q
-
N
Q
Q
S
L
D
M
R
K
L
G
E
L
E
A
D
L
K
E
K
D
S
M
V
-
E
S
L
-
T
E
T
I
G
I
L
R
K
E
L
E
N
-------------
E
K
L
K
A
--
A
E
N
-
M
D
S
F
E
K
L
S
M
E
N
E
N
L
K
E
K
I
A
H
---
Y
R
A
Q
R
F
--------------
4
PsiBlast_PDB
52.62
24%
119
- C2 -
4H0X
7
?
A:
[8-155]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
E
D
-
F
L
K
D
K
E
N
A
I
Q
W
E
K
K
E
A
E
R
V
E
K
N
L
D
T
L
E
K
E
A
L
E
L
Y
K
K
D
---
S
E
Q
I
S
N
Y
S
Q
T
R
Q
Y
F
Y
D
Y
Q
I
E
S
N
P
R
-
E
K
E
Y
K
N
-
L
R
N
A
I
S
---
K
--------
N
K
I
D
K
P
I
N
V
Y
Y
F
E
S
PEKFAFN
K
E
I
------------
R
T
E
-
N
Q
N
E
I
S
L
E
K
F
N
E
L
K
E
T
I
Q
D
K
L
F
K
Q
D
G
F
K
D
-
V
S
L
Y
E
P
G
N
G
D
E
K
P
T
P
L
L
-------------
I
H
L
K
L
--
P
K
N
-
T
G
M
L
P
Y
I
N
S
N
D
V
K
T
L
I
E
Q
D
Y
---
S
I
K
I
D
K
I
V
R
I
V
I
E
-------
9
PsiBlast_PDB
52.57
24%
128
- C2 -
1GIQ
-
?
A:
[3-150]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
E
D
-
F
L
K
D
K
E
N
A
I
Q
W
E
K
K
E
A
E
R
V
E
K
N
L
D
T
L
E
K
E
A
L
E
L
Y
K
K
D
---
S
E
Q
I
S
N
Y
S
Q
T
R
Q
Y
F
Y
D
Y
Q
I
E
S
N
P
R
-
E
K
E
Y
K
N
-
L
R
N
A
I
S
---
K
--------
N
K
I
D
K
P
I
N
V
Y
Y
F
E
S
PEKFAFN
K
E
I
------------
R
T
E
-
N
Q
N
E
I
S
L
E
K
F
N
E
L
K
E
T
I
Q
D
K
L
F
K
Q
D
G
F
K
D
-
V
S
L
Y
E
P
G
N
G
D
E
K
P
T
P
L
L
-------------
I
H
L
K
L
--
P
K
N
-
T
G
M
L
P
Y
I
N
S
N
D
V
K
T
L
I
E
Q
D
Y
---
S
I
K
I
D
K
I
V
R
I
V
I
E
-------
8
PsiBlast_PDB
52.44
24%
122
- C2 -
4H0T
7
?
A:
[8-155]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
E
D
-
F
L
K
D
K
E
N
A
I
Q
W
E
K
K
E
A
E
R
V
E
K
N
L
D
T
L
E
K
E
A
L
E
L
Y
K
K
D
---
S
E
Q
I
S
N
Y
S
Q
T
R
Q
Y
F
Y
D
Y
Q
I
E
S
N
P
R
-
E
K
E
Y
K
N
-
L
R
N
A
I
S
---
K
--------
N
K
I
D
K
P
I
N
V
Y
Y
F
E
S
PEKFAFN
K
E
I
------------
R
T
E
-
N
Q
N
E
I
S
L
E
K
F
N
E
L
K
E
T
I
Q
D
K
L
F
K
Q
D
G
F
K
D
-
V
S
L
Y
E
P
G
N
G
D
E
K
P
T
P
L
L
-------------
I
H
L
K
L
--
P
K
N
-
T
G
M
L
P
Y
I
N
S
N
D
V
K
T
L
I
E
Q
D
Y
---
S
I
K
I
D
K
I
V
R
I
V
I
E
-------
7
PsiBlast_PDB
52.14
24%
120
- C2 -
4H03
14
?
A:
[8-155]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
E
D
-
F
L
K
D
K
E
N
A
I
Q
W
E
K
K
E
A
E
R
V
E
K
N
L
D
T
L
E
K
E
A
L
E
L
Y
K
K
D
---
S
E
Q
I
S
N
Y
S
Q
T
R
Q
Y
F
Y
D
Y
Q
I
E
S
N
P
R
-
E
K
E
Y
K
N
-
L
R
N
A
I
S
---
K
--------
N
K
I
D
K
P
I
N
V
Y
Y
F
E
S
PEKFAFN
K
E
I
------------
R
T
E
-
N
Q
N
E
I
S
L
E
K
F
N
E
L
K
E
T
I
Q
D
K
L
F
K
Q
D
G
F
K
D
-
V
S
L
Y
E
P
G
N
G
D
E
K
P
T
P
L
L
-------------
I
H
L
K
L
--
P
K
N
-
T
G
M
L
P
Y
I
N
S
N
D
V
K
T
L
I
E
Q
D
Y
---
S
I
K
I
D
K
I
V
R
I
V
I
E
-------
3
PsiBlast_PDB
52.14
24%
121
* C2 *
4H0V
12
?
A:
[8-155]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
E
D
-
F
L
K
D
K
E
N
A
I
Q
W
E
K
K
E
A
E
R
V
E
K
N
L
D
T
L
E
K
E
A
L
E
L
Y
K
K
D
---
S
E
Q
I
S
N
Y
S
Q
T
R
Q
Y
F
Y
D
Y
Q
I
E
S
N
P
R
-
E
K
E
Y
K
N
-
L
R
N
A
I
S
---
K
--------
N
K
I
D
K
P
I
N
V
Y
Y
F
E
S
PEKFAFN
K
E
I
------------
R
T
E
-
N
Q
N
E
I
S
L
E
K
F
N
E
L
K
E
T
I
Q
D
K
L
F
K
Q
D
G
F
K
D
-
V
S
L
Y
E
P
G
N
G
D
E
K
P
T
P
L
L
-------------
I
H
L
K
L
--
P
K
N
-
T
G
M
L
P
Y
I
N
S
N
D
V
K
T
L
I
E
Q
D
Y
---
S
I
K
I
D
K
I
V
R
I
V
I
E
-------
6
PsiBlast_PDB
51.76
24%
126
- C2 -
4GY2
1
?
A:
[8-155]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
E
D
-
F
L
K
D
K
E
N
A
I
Q
W
E
K
K
E
A
E
R
V
E
K
N
L
D
T
L
E
K
E
A
L
E
L
Y
K
K
D
---
S
E
Q
I
S
N
Y
S
Q
T
R
Q
Y
F
Y
D
Y
Q
I
E
S
N
P
R
-
E
K
E
Y
K
N
-
L
R
N
A
I
S
---
K
--------
N
K
I
D
K
P
I
N
V
Y
Y
F
E
SPEKFAFN
K
E
I
------------
R
T
E
-
N
Q
N
E
I
S
L
E
K
F
N
E
L
K
E
T
I
Q
D
K
L
F
K
Q
D
G
F
K
D
-
V
S
L
Y
E
P
G
N
G
D
E
K
P
T
P
L
L
-------------
I
H
L
K
L
--
P
K
N
-
T
G
M
L
P
Y
I
N
S
N
D
V
K
T
L
I
E
Q
D
Y
---
S
I
K
I
D
K
I
V
R
I
V
I
E
-------
5
PsiBlast_PDB
51.76
24%
122
- C2 -
4H0Y
14
?
A:
[8-155]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
E
D
-
F
L
K
D
K
E
N
A
I
Q
W
E
K
K
E
A
E
R
V
E
K
N
L
D
T
L
E
K
E
A
L
E
L
Y
K
K
D
---
S
E
Q
I
S
N
Y
S
Q
T
R
Q
Y
F
Y
D
Y
Q
I
E
S
N
P
R
-
E
K
E
Y
K
N
-
L
R
N
A
I
S
---
K
--------
N
K
I
D
K
P
I
N
V
Y
Y
F
E
S
PEKFAFN
K
E
I
------------
R
T
E
-
N
Q
N
E
I
S
L
E
K
F
N
E
L
K
E
T
I
Q
D
K
L
F
K
Q
D
G
F
K
D
-
V
S
L
Y
E
P
G
N
G
D
E
K
P
T
P
L
L
-------------
I
H
L
K
L
--
P
K
N
-
T
G
M
L
P
Y
I
N
S
N
D
V
K
T
L
I
E
Q
D
Y
---
S
I
K
I
D
K
I
V
R
I
V
I
E
-------
10
PsiBlast_PDB
51.62
24%
123
- C2 -
1GIR
-
?
A:
[3-150]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
E
D
-
F
L
K
D
K
E
N
A
I
Q
W
E
K
K
E
A
E
R
V
E
K
N
L
D
T
L
E
K
E
A
L
E
L
Y
K
K
D
---
S
E
Q
I
S
N
Y
S
Q
T
R
Q
Y
F
Y
D
Y
Q
I
E
S
N
P
R
-
E
K
E
Y
K
N
-
L
R
N
A
I
S
---
K
--------
N
K
I
D
K
P
I
N
V
Y
Y
F
E
S
PEKFAFN
K
E
I
------------
R
T
E
-
N
Q
N
E
I
S
L
E
K
F
N
E
L
K
E
T
I
Q
D
K
L
F
K
Q
D
G
F
K
D
-
V
S
L
Y
E
P
G
N
G
D
E
K
P
T
P
L
L
-------------
I
H
L
K
L
--
P
K
N
-
T
G
M
L
P
Y
I
N
S
N
D
V
K
T
L
I
E
Q
D
Y
---
S
I
K
I
D
K
I
V
R
I
V
I
E
-------
11
PsiBlast_PDB
50.41
24%
125
- C2 -
3BUZ
-
?
A:
[3-150]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
P
E
D
-
F
L
K
D
K
E
N
A
I
Q
W
E
K
K
E
A
E
R
V
E
K
N
L
D
T
L
E
K
E
A
L
E
L
Y
K
K
D
---
S
E
Q
I
S
N
Y
S
Q
T
R
Q
Y
F
Y
D
Y
Q
I
E
S
N
P
R
-
E
K
E
Y
K
N
-
L
R
N
A
I
S
---
K
--------
N
K
I
D
K
P
I
N
V
Y
Y
F
E
S
PEKFAFN
K
E
I
------------
R
T
E
-
N
Q
N
E
I
S
L
E
K
F
N
E
L
K
E
T
I
Q
D
K
L
F
K
Q
D
G
F
K
D
-
V
S
L
Y
E
P
G
N
G
D
E
K
P
T
P
L
L
-------------
I
H
L
K
L
--
P
K
N
-
T
G
M
L
P
Y
I
N
S
N
D
V
K
T
L
I
E
Q
D
Y
---
S
I
K
I
D
K
I
V
R
I
V
I
E
-------
12
PsiBlast_PDB
43.35
19%
112
- C4 -
2I1K
-
?
A:
[301-450]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Q
Q
M
K
A
---
Q
A
R
E
---
E
K
L
A
K
Q
A
Q
R
-----
E
I
A
A
R
E
R
A
E
K
K
Q
Q
E
Y
Q
D
-
R
L
R
Q
M
Q
---
E
--------
E
M
E
R
S
Q
A
N
L
L
E
A
Q
--------
D
M
I
L
R
L
E
E
Q
L
R
Q
L
Q
A
A
K
E
-
E
L
E
Q
R
Q
N
E
L
Q
A
M
M
Q
R
L
E
E
T
----------L
E
D
E
-
I
R
A
K
Q
E
E
V
S
R
I
Q
Q
-------------
E
V
E
L
K
--
D
S
E
T
R
R
L
Q
E
E
V
E
D
A
R
R
K
Q
D
E
A
A
A
A
---
L
L
A
A
T
T
P
Q
H
H
H
V
A
-------
32
Fugue
41.75
10%
80
- C4 -
4CPC
-
SYCP3_HUMAN
A:
[18-160]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
K
A
L
L
A
K
R
K
R
L
---
E
M
Y
T
---
K
A
S
L
K
T
S
N
Q
K
I
E
H
V
W
K
T
Q
Q
D
Q
R
Q
K
L
N
Q
E
Y
S
Q
-
Q
F
L
T
L
F
---
Q
--------
Q
W
D
L
D
M
Q
K
A
E
E
Q
E
--------
E
K
I
------------
L
N
M
-
F
R
Q
Q
Q
K
I
L
Q
Q
S
R
I
V
Q
S
Q
R
L
K
T
I
K
Q
L
Y
E
Q
F
-
I
K
S
-
M
E
E
L
E
K
N
H
D
N
L
L
T
-------------
G
A
Q
N
E
--
F
K
K
-
E
M
A
M
L
Q
K
K
I
M
M
E
T
Q
Q
Q
E
--------------------------
16
PsiBlast_PDB
41.28
26%
115
- C4 -
1CII
-
CEIA_ECOLX
A:
[377-507]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
R
L
L
D
A
R
N
K
I
T
S
A
E
-
S
----
A
---
V
--------
N
S
A
R
N
N
L
S
A
R
T
N
E
------------------------
Q
K
-
H
A
N
D
A
L
---
N
A
L
L
K
E
K
E
N
I
R
N
Q
L
S
G
I
N
Q
K
-
I
A
E
-
E
K
R
K
Q
D
E
L
K
A
T
K
D
A
I
N
F
T
T
E
F
L
K
S
V
S
E
K
Y
G
A
--
K
A
E
-
Q
L
A
R
E
M
A
G
Q
A
K
G
K
K
I
R
N
V
E
E
A
L
K
T
Y
E
K
Y
R
A
-
D
I
N
K
K
-------
21
HHSearch
41.19
15%
-82
- C1 -
3HRG
2
?
A:
[102-192]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
N
E
I
V
M
Y
N
I
L
K
KN
N
V
V
I
I
F
G
I
D
K
S
T
Y
T
F
L
N
E
Q
Y
P
E
A
R
F
Y
S
Q
--
S
T
P
L
I
E
Y
F
S
I
K
S
R
L
G
N
S
K
K
M
Y
A
S
V
R
K
D
A
I
D
I
Y
-
C
F
E
R
G
Q
L
L
L
A
N
S
F
E
C
M
Q
T
E
D
R
I
Y
Y
L
L
Y
V
W
K
Q
L
E
F
N
Q
E
R
D
E
L
H
L
T
G
T
L
S
D
K
E
T
L
M
N
E
L
K
K
F
I
L
Q
V
F
I
M
N
P
--
A
N
N
I
D
M
Q
A
L
L
T
C
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
35.42
22%
154
- C4 -
1W9R
-
?
A:
[1-119]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---
S
H
M
P
---
E
K
K
V
A
E
A
E
K
K
V
E
E
A
K
K
K
A
E
D
Q
K
E
E
D
R
R
N
Y
P
T
N
T
Y
K
T
L
E
---
L
--------
E
I
A
E
S
D
V
E
V
K
K
A
E
--------
L
E
L
------------
V
K
E
-
E
A
K
E
P
R
N
E
E
K
V
K
Q
A
K
A
E
V
E
S
K
K
A
E
A
T
R
L
E
-
K
I
K
-
T
D
R
K
K
A
E
E
E
A
K
R
K
-------------
A
A
E
E
D
--
K
V
K
-
E
K
P
----------------------------------------
14
PsiBlast_PDB
34.64
23%
109
- C4 -
3M3W
-
PACN3_MOUSE
A:
[94-229]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
L
E
V
R
E
K
L
H
G
P
D
S
E
R
V
R
T
W
-
Q
R
G
A
F
H
GFR
A
--------
S
R
A
A
E
D
G
F
R
K
A
Q
K
--------
P
W
L
------------
K
R
L
-
K
E
V
E
A
S
K
K
S
Y
H
T
A
R
K
D
E
K
T
A
Q
T
R
E
S
H
A
K
---
A
D
-
S
S
M
---
Q
L
R
K
L
Q
E
-------------
R
V
G
R
C
T
K
E
A
E
-
K
M
K
T
Q
Y
E
Q
T
L
A
E
L
N
R
Y
T
P
R
Y
---
M
E
D
M
E
Q
A
F
E
S
C
Q
A
-------
15
PsiBlast_PDB
34.10
23%
101
- C4 -
3QE6
-
PACN3_MOUSE
A:
[94-229]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
L
E
V
R
E
K
L
H
G
P
D
S
E
R
V
R
T
W
-
Q
R
G
A
F
H
---
R
P
VLGGF
R
E
S
R
A
A
E
D
G
F
R
K
A
Q
K
--------
P
W
L
------------
K
R
L
-
K
E
V
E
A
S
K
K
S
Y
H
T
A
R
K
D
E
K
T
A
Q
T
R
E
S
H
A
-----------
Q
E
Q
L
R
K
L
Q
E
-------------
R
V
G
R
C
T
K
E
A
E
-
K
M
K
T
Q
Y
E
Q
T
L
A
E
L
N
R
Y
T
P
R
Y
---
M
E
D
M
E
Q
A
F
E
S
C
Q
A
-------
30
Fugue
33.92
27%
161
- C4 -
4C7N
1
A:
[2-48]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
D
Y
I
R
K
L
Q
R
-------------
E
Q
Q
R
A
--
K
E
L
-
E
N
R
Q
K
K
L
E
H
A
N
R
H
L
L
L
R
I
Q
E
---
L
E
M
Q
A
R
A
H
------------