@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0474: (2015-12-15 )
MTEDRLSAEDKKFLEVERALKEAALNPLRHATEELFGDFLKMENITEICYNGDKVVWVLKNNGEWQPFDVRNKKAFSLSRLMHFARCCASFKKKTIDNYENPILSSNLANGERVQIVLSPVTVNDETISISIRIPSKTTYPHSFFEEQGFYNLLDNKEQAISAIKDGIAIGKNVIVCGGTGSGKTTYIKSIMEFIPKEERIISIEDTEEIVFKHHKNYTQLFFGGNITSADCLKSCLRMRPDRIILGELRSSEAYDFYNVLCSGHKGTLTTLHAGSSEEAFIRLANMSSSNSAARNIKFESLIEGFKDLIDMIVHINHHKQCDEFYIKHR
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------.........10........20...-----.....30........40........50....---....60........70........80........90..-.....---.100.......110.-........120....-...130......--.140.......150---------------....-----------------...160.....-....170.......180..-.....190...--...--.--200.........210.......--220-..-----.-----.....230.......240.......250..-.-..-..260.......270.........280.....--..290.......300.......310--.......320........330----------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------MTEDRLSA
E
D
K
K
F
L
E
V
E
R
A
L
K
E
AA-----L
N
P
L
R
H
A
T
E
E
L
F
G
D
F
L
K
M
E
N
I
T
E
I
CYNG
D
K
V
---
V
W
V
L
KNNGEWQPFDVRN
K
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
A
S
F
K
K
-
K
T
IDN---YENPILSSNLAN--G-
E
R
V
Q
I
V
L
S
P
V
T
VND
E
-
T
I
S
I
S
I
RIPSKT--TYP
H
S
F
F
E
EQ
G
F
Y
N
---------------LLD
N
-----------------
K
E
Q
A
--
I
S
A
I
K
-
D
G
I
AIGK
N
V
I
V
CGGTGSG
K
-
T
T
Y
I
K
S
I
M
E
FI--PKE--
E
--
R
--
I
I
S
IE
D
T
E
E
I
V
F
K
HHKN
Y
T
--
Q
L
--
F
F-----G-----GNI
T
S
A
D
C
L
K
S
C
L
RMRPD
R
I
I
L
G
ELRSS
E
A
-
Y
-
D
F
-
Y
N
V
L
CSGHKG
T
L
T
--
T
L
HAGSSE
E
A
F
I
R
L
ANM--SSSNSAARNI
K
F
E
S
L
I
E
G
F
K
D
L
I
D
M
--
I
V
HIN
H
H
K
-
Q
C
D
E
F
Y
IKHR------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
99.22
99%
-130
- C2 -
2PT7
-
?
A:
[6-328]
-------------------------------------------------------------------------------------------------------------
L
S
A
E
D
K
K
F
L
E
V
E
R
A
L
K
E
A
A
-----
L
N
P
L
R
H
A
T
E
E
L
F
G
D
F
L
K
M
E
N
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
N
N
G
E
W
Q
P
F
D
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
A
S
F
K
K
-
K
T
I
D
N
---
Y
E
N
P
I
L
S
S
N
L
A
N
--
G
-
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
E
-
T
I
S
I
S
I
R
I
P
S
K
T
--
T
Y
P
H
S
F
F
E
E
Q
G
F
Y
N
---------------
L
L
D
N
-----------------
K
E
Q
A
--
I
S
A
I
K
-
D
G
I
A
I
G
K
N
V
I
V
C
G
G
T
G
S
G
K
-
T
T
Y
I
K
S
I
M
E
F
I
--
P
K
E
--
E
--
R
--
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
--
Q
L
--
F
F
-----
G
-----
G
N
I
T
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
L
R
S
S
E
A
-
Y
-
D
F
-
Y
N
V
L
C
S
G
H
K
G
T
L
T
--
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
N
M
--
S
S
S
N
S
A
A
R
N
I
K
F
E
S
L
I
E
G
F
K
D
L
I
D
M
--
I
V
H
I
N
H
H
K
-
Q
C
D
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
98.32
97%
-127
- C2 -
1G6O
1
?
A:
[6-328]
-------------------------------------------------------------------------------------------------------------
L
S
A
E
D
K
K
F
L
E
V
E
R
A
L
K
E
A
A
-----
L
N
P
L
R
H
A
T
E
E
L
F
G
D
F
L
K
M
E
N
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
N
N
G
E
W
Q
P
F
D
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
A
S
F
K
K
-
K
T
I
D
N
---
Y
E
N
P
I
L
S
S
N
L
A
N
--
G
-
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
E
-
T
I
S
I
S
I
R
I
P
S
K
T
--
T
Y
P
H
S
F
F
E
E
Q
G
F
Y
N
---------------
L
L
D
N
-----------------
K
E
Q
A
--
I
S
A
I
K
-
D
G
I
A
I
G
K
N
V
I
V
C
G
G
T
G
S
G
K
-
T
T
Y
I
K
S
I
M
E
F
I
--
P
K
E
--
E
--
R
--
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
--
Q
L
--
F
F
-----
G
-----
G
N
I
T
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
L
R
S
S
E
A
-
Y
-
D
F
-
Y
N
V
L
C
S
G
H
K
G
T
L
T
--
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
N
M
--
S
S
S
N
S
A
A
R
N
I
K
F
E
S
L
I
E
G
F
K
D
L
I
D
M
--
I
V
H
I
N
H
H
K
-
Q
C
D
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
97.84
97%
-126
- C2 -
1OPX
1
?
A:
[6-328]
-------------------------------------------------------------------------------------------------------------
L
S
A
E
D
K
K
F
L
E
V
E
R
A
L
K
E
A
A
-----
L
N
P
L
R
H
A
T
E
E
L
F
G
D
F
L
K
M
E
N
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
N
N
G
E
W
Q
P
F
D
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
A
S
F
K
K
-
K
T
I
D
N
---
Y
E
N
P
I
L
S
S
N
L
A
N
--
G
-
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
E
-
T
I
S
I
S
I
R
I
P
S
K
T
--
T
Y
P
H
S
F
F
E
E
Q
G
F
Y
N
---------------
L
L
D
N
-----------------
K
E
Q
A
--
I
S
A
I
K
-
D
G
I
A
I
G
K
N
V
I
V
C
G
G
T
G
S
G
K
-
T
T
Y
I
K
S
I
M
E
F
I
--
P
K
E
--
E
--
R
--
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
--
Q
L
--
F
F
-----
G
-----
G
N
I
T
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
L
R
S
S
E
A
-
Y
-
D
F
-
Y
N
V
L
C
S
G
H
K
G
T
L
T
--
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
N
M
--
S
S
S
N
S
A
A
R
N
I
K
F
E
S
L
I
E
G
F
K
D
L
I
D
M
--
I
V
H
I
N
H
H
K
-
Q
C
D
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
97.36
97%
-122
- C2 -
1NLY
2
?
A:
[6-328]
-------------------------------------------------------------------------------------------------------------
L
S
A
E
D
K
K
F
L
E
V
E
R
A
L
K
E
A
A
-----
L
N
P
L
R
H
A
T
E
E
L
F
G
D
F
L
K
M
E
N
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
N
N
G
E
W
Q
P
F
D
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
A
S
F
K
K
-
K
T
I
D
N
---
Y
E
N
P
I
L
S
S
N
L
A
N
--
G
-
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
E
-
T
I
S
I
S
I
R
I
P
S
K
T
--
T
Y
P
H
S
F
F
E
E
Q
G
F
Y
N
---------------
L
L
D
N
-----------------
K
E
Q
A
--
I
S
A
I
K
-
D
G
I
A
I
G
K
N
V
I
V
C
G
G
T
G
S
G
K
-
T
T
Y
I
K
S
I
M
E
F
I
--
P
K
E
--
E
--
R
--
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
--
Q
L
--
F
F
-----
G
-----
G
N
I
T
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
L
R
S
S
E
A
-
Y
-
D
F
-
Y
N
V
L
C
S
G
H
K
G
T
L
T
--
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
N
M
--
S
S
S
N
S
A
A
R
N
I
K
F
E
S
L
I
E
G
F
K
D
L
I
D
M
--
I
V
H
I
N
H
H
K
-
Q
C
D
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------------
35
HHSearch
96.97
98%
-133
- C2 -
2PT7
-
?
A:
[6-319]
-------------------------------------------------------------------------------------------------------------
L
S
A
E
D
K
K
F
L
E
V
E
R
A
L
K
E
A
A
-----
L
N
P
L
R
H
A
T
E
E
L
F
G
D
F
L
K
M
E
N
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
N
N
G
E
W
Q
P
F
D
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
A
S
F
K
K
-
K
T
I
D
N
---
Y
E
N
P
I
L
S
S
N
L
A
N
--
G
-
E
R
V
Q
I
V
L
S
P
V
T
V
-
N
D
E
T
I
S
I
S
I
R
I
P
S
K
T
--
T
Y
P
H
S
F
F
E
E
Q
G
F
Y
N
---------------
L
L
D
N
-----------------
K
E
Q
A
--
I
S
A
I
K
-
D
G
I
A
I
G
K
N
V
I
V
C
G
G
T
G
S
G
K
-
T
T
Y
I
K
S
I
M
E
F
I
--
P
K
E
--
E
--
R
--
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
--
Q
L
--
F
F
-----
G
-----
G
N
I
T
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
L
R
S
S
E
A
-
Y
-
D
F
-
Y
N
V
L
C
S
G
H
K
G
T
L
T
--
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
N
M
--
S
S
S
N
S
A
A
R
N
I
K
F
E
S
L
I
E
G
F
K
D
L
I
D
M
--
I
V
H
I
N
H
H
K
-
Q
C
D
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------------
34
HHSearch
77.84
35%
-134
- C2 -
2GZA
2
VIRBB_BRUSU
A:
[24-343]
------------------------------------------------------------------------------------------------------------------------------------------
F
H
L
-
E
P
L
R
P
W
L
D
D
P
Q
I
T
E
V
C
V
N
R
P
G
E
---
V
F
C
E
R
A
-
S
A
W
E
Y
Y
A
V
---
P
N
L
D
Y
E
H
L
I
S
L
G
T
A
T
A
R
F
V
D
-
Q
D
I
S
----
D
S
R
P
V
L
S
A
I
L
P
M
--
G
-
E
R
I
Q
I
V
R
P
P
A
C
E
-
H
G
-
T
I
S
V
T
I
R
K
P
S
F
T
--
R
R
T
L
E
D
Y
A
Q
Q
G
F
F
K
---------------
H
V
R
P
MSKSLT
P
F
E
Q
E
L
L
A
L
K
E
A
G
D
Y
--
M
S
F
L
R
-
R
A
V
Q
L
E
R
V
I
V
V
A
G
E
T
G
S
G
K
-
T
T
L
M
K
A
L
M
Q
E
I
--
P
F
D
--
Q
--
R
--
L
I
T
I
E
D
V
P
E
L
F
L
P
D
H
P
N
H
V
--
H
L
--
F
Y
-----
P
-------
V
T
A
A
T
L
L
R
S
C
L
R
M
K
P
T
R
I
L
L
A
E
L
R
G
G
E
A
-
Y
-
D
F
-
I
N
V
A
A
S
G
H
G
G
S
I
T
--
S
C
H
A
G
S
C
E
L
T
F
E
R
L
A
L
M
--
V
L
Q
N
R
Q
G
R
Q
L
P
Y
E
I
I
R
R
L
L
Y
L
V
V
D
V
--
V
V
H
V
H
N
G
V
H
D
G
T
G
R
H
I
S
E
V
------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.23
35%
-121
- C2 -
2GZA
1
VIRBB_BRUSU
B:
[20-312]
-------------------------------------------------------------------------------------------------------------------------------
A
S
V
N
F
H
L
E
P
L
R
--------
P
W
L
D
D
P
Q
I
T
E
V
C
V
N
R
P
G
E
---
V
F
C
E
R
A
S
A
-
W
E
Y
Y
A
V
P
N
---
L
D
Y
E
H
L
I
S
L
G
T
A
T
A
R
F
V
D
-
Q
D
I
S
D
----
S
R
P
V
L
S
A
I
L
P
M
--
G
-
E
R
I
Q
I
V
R
P
P
A
C
E
H
G
--
T
I
S
V
T
I
R
K
P
S
F
T
--
R
R
T
L
E
D
Y
A
Q
Q
G
F
F
K
HVRPMSKSLT
P
F
E
Q
E
L
L
A
L
-----------------
K
E
A
G
D
Y
M
S
F
L
R
-
R
A
V
Q
L
E
R
V
I
V
V
A
G
E
T
G
S
G
K
-
T
T
L
M
K
A
L
M
Q
E
I
--
P
F
D
--
Q
--
R
--
L
I
T
I
E
D
V
P
E
L
F
L
P
D
H
P
N
H
V
--
H
L
--
F
Y
P-----------
P
V
T
A
A
T
L
L
R
S
C
L
R
M
K
P
T
R
I
L
L
A
E
L
R
G
G
E
A
-
Y
-
D
F
-
I
N
V
A
A
S
G
H
G
G
S
I
T
--
S
C
H
A
G
S
C
E
L
T
F
E
R
L
A
L
M
--
V
L
Q
N
R
Q
G
R
Q
L
P
Y
E
I
I
R
R
L
L
Y
L
V
V
D
V
--
V
V
H
V
H
N
G
V
-
H
D
G
T
G
R
H
I
S
E
------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.09
35%
-125
- C2 -
2GZA
2
VIRBB_BRUSU
A:
[20-312]
-------------------------------------------------------------------------------------------------------------------------------
A
S
V
N
F
H
L
E
P
L
R
--------
P
W
L
D
D
P
Q
I
T
E
V
C
V
N
R
P
G
E
---
V
F
C
E
R
A
S
A
-
W
E
Y
Y
A
V
P
N
---
L
D
Y
E
H
L
I
S
L
G
T
A
T
A
R
F
V
D
-
Q
D
I
S
D
----
S
R
P
V
L
S
A
I
L
P
M
--
G
-
E
R
I
Q
I
V
R
P
P
A
C
E
H
G
--
T
I
S
V
T
I
R
K
P
S
F
T
--
R
R
T
L
E
D
Y
A
Q
Q
G
F
F
K
HVRPMSKSLT
P
F
E
Q
E
L
L
A
L
-----------------
K
E
A
G
D
Y
M
S
F
L
R
-
R
A
V
Q
L
E
R
V
I
V
V
A
G
E
T
G
S
G
K
-
T
T
L
M
K
A
L
M
Q
E
I
--
P
F
D
--
Q
--
R
--
L
I
T
I
E
D
V
P
E
L
F
L
P
D
H
P
N
H
V
--
H
L
--
F
Y
P------------
V
T
A
A
T
L
L
R
S
C
L
R
M
K
P
T
R
I
L
L
A
E
L
R
G
G
E
A
-
Y
-
D
F
-
I
N
V
A
A
S
G
H
G
G
S
I
T
--
S
C
H
A
G
S
C
E
L
T
F
E
R
L
A
L
M
--
V
L
Q
N
R
Q
G
R
Q
L
P
Y
E
I
I
R
R
L
L
Y
L
V
V
D
V
--
V
V
H
V
H
N
G
V
-
H
D
G
T
G
R
H
I
S
E
------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
70.08
35%
-122
- C2 -
2GZA
1
VIRBB_BRUSU
C:
[13-312]
------------------------------------------------------------------------------------------------------------------------
E
A
A
V
K
R
A
A
S
V
N
F
H
L
E
P
L
R
--------
P
W
L
D
D
P
Q
I
T
E
V
C
V
N
R
P
G
E
---
V
F
C
E
R
A
S
A
-
W
E
Y
Y
A
V
P
N
---
L
D
Y
E
H
L
I
S
L
G
T
A
T
A
R
F
V
D
-
Q
D
I
S
D
----
S
R
P
V
L
S
A
I
L
P
M
--
G
-
E
R
I
Q
I
V
R
P
P
A
C
E
H
G
--
T
I
S
V
T
I
R
K
P
S
F
T
--
R
R
T
L
E
D
Y
A
Q
Q
G
F
F
K
HVRPMSKSLTPF
E
Q
E
L
L
A
L
-----------------
K
E
A
G
D
Y
M
S
F
L
R
-
R
A
V
Q
L
E
R
V
I
V
V
A
G
E
T
G
S
G
K
-
T
T
L
M
K
A
L
M
Q
E
I
--
P
F
D
--
Q
--
R
--
L
I
T
I
E
D
V
P
E
L
F
L
P
D
H
P
N
H
V
--
H
L
--
F
Y
P-----------
P
V
T
A
A
T
L
L
R
S
C
L
R
M
K
P
T
R
I
L
L
A
E
L
R
G
G
E
A
-
Y
-
D
F
-
I
N
V
A
A
S
G
H
G
G
S
I
T
--
S
C
H
A
G
S
C
E
L
T
F
E
R
L
A
L
M
--
V
L
Q
N
R
Q
G
R
Q
L
P
Y
E
I
I
R
R
L
L
Y
L
V
V
D
V
--
V
V
H
V
H
N
G
V
-
H
D
G
T
G
R
H
I
S
E
------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.16
97%
15
- C2 -
1NLZ
-
?
A:
[6-328]
-------------------------------------------------------------------------------------------------------------
L
S
A
E
D
K
K
F
L
E
V
E
R
A
L
K
E
A
A
-----
L
N
P
L
R
H
A
T
E
E
L
F
G
D
F
L
K
M
E
N
I
T
E
I
C
Y
N
G
N
K
V
---
V
W
V
L
K
N
N
G
E
W
Q
P
F
D
V
R
D
R
K
A
F
S
L
S
R
L
M
H
F
A
R
C
C
A
S
F
K
K
-
K
T
I
D
N
---
Y
E
N
P
I
L
S
S
N
L
A
N
--
G
-
E
R
V
Q
I
V
L
S
P
V
T
V
N
D
E
-
T
I
S
I
S
I
R
I
P
S
K
T
--
T
Y
P
H
S
F
F
E
E
Q
G
F
Y
N
---------------
L
L
D
N
-----------------
K
E
Q
A
--
I
S
A
I
K
-
D
G
I
A
I
G
K
N
V
I
V
C
G
G
T
G
S
G
K
-
T
T
Y
I
K
S
I
M
E
F
I
--
P
K
E
--
E
--
R
--
I
I
S
I
E
D
T
E
E
I
V
F
K
H
H
K
N
Y
T
--
Q
L
--
F
F
-----
G
-----
G
N
I
T
S
A
D
C
L
K
S
C
L
R
M
R
P
D
R
I
I
L
G
E
L
R
S
S
E
A
-
Y
-
D
F
-
Y
N
V
L
C
S
G
H
K
G
T
L
T
--
T
L
H
A
G
S
S
E
E
A
F
I
R
L
A
N
M
--
S
S
S
N
S
A
A
R
N
I
K
F
E
S
L
I
E
G
F
K
D
L
I
D
M
--
I
V
H
I
N
H
H
K
-
Q
C
D
E
F
Y
I
K
--------------------------------------------------------------------------------------------------------------
58
Fugue
59.06
23%
-87
- C2 -
4IHQ
5
?
A:
[2-513]
S
F
V
E
D
Y
L
T
K
LQ
E
R
P
T
I
I
ENPNILKGSKI
F
N
A
I
Y
R
V
D
DF
V
Y
I
H
I
Q
SIKSEDG
Y
N
Q
Y
N
V
I
E
P
P
RPT
H
D
E
M
E
E
I
E
E
K
F
A
L
S
IGD
K
E
P
P
ED
T
K
E
K
E
K
L
I
R
S
I
L
D
K
I
L
L
R
M
R
L
S
V
P
K
E
Y
V
I
Y
H
F
I
R
D
K
L
Y
T
G
S
-----
L
E
P
L
I
R
D
-----------
P
Y
I
E
D
I
S
I
P
G
L
G
H
---
V
Y
I
V
H
K
V
F
G
P
M
R
T
S
I
K
F
E
---
N
Y
E
E
L
D
N
L
I
V
S
L
S
E
K
S
Y
-
R
P
V
-
S
---
H
N
R
P
V
V
D
A
S
L
P
D
--
G
-
S
R
V
N
F
V
Y
G
V
D
I
S
R
R
G
-
S
-
N
L
T
V
R
K
F
S
R
V
--
P
T
S
I
T
Q
L
I
M
F
G
T
L
S
-------------------------------------
S
M
M
--
A
A
Y
I
W
-
T
M
L
D
E
G
M
N
L
F
V
C
G
E
T
A
S
G
K
-
T
T
T
L
N
A
I
T
A
F
I
--
P
P
N
--
L
--
K
--
I
V
T
I
E
D
T
P
E
L
T
V
-
P
H
S
N
W
V
--
A
E
--
V
T
R
E
TGG
E
-----
G
T
I
K
L
F
D
L
L
K
A
A
L
R
Q
R
P
N
Y
I
L
V
G
A
I
R
D
K
E
G
-
N
-
V
A
-
F
Q
A
M
Q
T
G
H
-
S
V
M
A
--
T
F
H
A
A
N
I
T
T
L
I
Q
R
L
T
G
----------------
Y
P
I
E
V
P
K
S
Y
I
N
N
LN
I
A
L
F
Q
T
A
L
-
Y
D
K
K
G
N
L
I
R
R
VV
E
V
D
E
I
I
DIDPVTN
D
V
V
Y
I
PA
F
T
Y
D
SVQD
K
M
L
F
AGKGSSYLIENK
I
A
V
K
R
GIDRRNI
G
L
L
Y
D
E
L
Q
M
R
S
R
F
L
N
L
L
V
E
K
KIFN
Y
Y
D
V
W
D
Y
I
L
R
A
R
Q
MG
L
E
E
A
I
K
Y
V
SNI
37
HHSearch
53.56
17%
-106
- C2 -
3JVV
3
PILT_PSEAE
A:
[5-270]
-----------------------------------------------------------------------------------------------------------------------------------------------
E
L
L
A
F
S
A
K
Q
G
A
S
D
L
H
L
S
A
G
L
P
---
P
M
I
R
V
D
-
G
D
V
R
R
I
N
L
---
P
P
L
E
H
K
Q
V
H
A
L
I
Y
D
I
M
N
D
K
Q
R
K
D
F
E
E
---
F
L
E
T
D
F
S
F
E
V
P
G
--
V
-
A
R
F
R
V
N
A
F
N
Q
N
R
----
G
A
G
A
V
F
R
T
I
P
S
K
--
V
L
T
M
E
E
L
---
G
M
G
E
----------------
V
---------------------------
F
K
R
-
V
S
D
V
P
R
G
L
V
L
V
T
G
P
T
G
S
G
K
-
S
T
T
L
A
A
M
L
D
Y
L
--
N
N
T
KY
H
--
H
--
I
L
T
I
E
D
P
I
E
F
V
H
E
S
---
K
K
--
C
L
--
V
N
-----
Q
R
E
V
HR
D
T
L
G
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
-
I
R
L
A
-
L
T
A
A
E
T
G
H
L
-
V
F
G
--
T
L
H
T
T
S
A
A
K
T
I
D
R
V
V
D
V
--
F
P
A
E
------
E
K
A
M
V
R
S
M
L
S
E
S
L
Q
S
--
V
I
S
Q
T
L
I
K
-
K
R
V
A
A
H
E
I
M
I
------------------------------------------------------------------------------------------------------------
38
HHSearch
51.13
21%
-92
- C2 -
2EWV
1
?
A:
[16-283]
----------------------------------------------------------------------------------------------------------------------------------------------
L
E
I
I
K
E
A
I
E
L
G
A
S
D
I
H
L
T
A
G
A
P
---
P
A
V
R
I
D
-
G
Y
I
K
F
L
K
D
F
--
P
R
L
T
P
E
D
T
Q
K
L
A
Y
S
V
M
S
E
K
H
-
R
Q
K
L
----
E
E
N
G
Q
V
D
F
S
F
G
V
RG
V
-
G
R
F
R
A
N
V
F
Y
Q
R
G
----
S
V
A
A
A
L
R
S
L
P
A
E
--
I
P
E
F
K
K
L
---
G
L
P
D
---------------
K
----------------------------
V
L
E
-
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
-
S
T
T
I
A
S
M
I
D
Y
I
--
N
Q
T
--
K
SY
H
--
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
K
S
I
V
--
N
Q
R
E
V
G
-----
E
-----
D
T
K
S
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
-
T
A
-
L
R
A
A
E
T
G
H
L
-
V
F
G
--
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
I
--
F
P
L
N
Q
------
Q
E
Q
V
R
I
V
L
S
F
I
L
Q
G
--
I
I
S
Q
R
L
L
P
-
K
I
G
G
G
R
V
L
A
Y
------------------------------------------------------------------------------------------------------------
43
HHSearch
49.48
28%
-87
- C2 -
2EYU
-
?
A:
[17-172]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
E
-
L
C
H
R
K
M
G
L
I
L
V
T
G
P
T
G
S
G
K
-
S
T
T
I
A
S
M
I
D
Y
I
--
N
Q
T
--
K
--
S
Y
H
I
I
T
I
E
D
P
I
E
Y
V
F
K
H
K
K
S
I
V
--
N
Q
R
E
V
G
-----
E
-----
D
T
K
S
F
A
D
A
L
R
A
A
L
R
E
D
P
D
V
I
F
V
G
E
M
R
D
L
E
T
V
E
-
T
A
-
L
R
A
A
E
T
G
H
L
-
V
F
G
--
T
L
H
T
N
T
A
I
D
T
I
H
R
I
V
D
I
--
F
P
L
N
Q
------
Q
E
Q
V
R
I
V
L
S
F
I
L
Q
G
--
I
I
S
Q
R
L
L
P
-
K
I
G
G
G
R
V
L
A
Y
------------------------------------------------------------------------------------------------------------
39
HHSearch
49.23
19%
-100
- C2 -
1P9R
1
GSPE_VIBCH
A:
[35-303]
------------------------------------------------------------------------------------------------------------------------------------------
K
L
I
-
N
A
M
L
G
E
A
I
K
E
G
A
S
D
I
H
I
E
T
F
E
K
T
L
S
I
R
F
R
V
D
-
G
V
L
R
E
V
L
A
-----
P
S
R
K
L
S
S
L
L
V
S
R
V
K
V
M
A
K
-
L
D
I
A
E
KR
V
P
Q
D
G
R
I
S
L
-------A
V
D
V
R
V
S
T
M
P
S
S
H
----
G
E
R
V
V
M
R
L
L
D
K
N
AT
R
L
D
L
H
S
L
---
G
M
T
A
---------------
H
N
-------------------------
H
D
N
F
R
R
L
I
K
R
P
H
G
I
I
L
V
T
G
P
T
G
S
G
K
-
S
T
T
L
Y
A
G
L
Q
E
L
--
N
S
S
--
E
--
R
N
-
I
L
T
V
E
D
P
I
E
F
D
I
D
G
-
I
G
Q
T
--
Q
V
--
N
P
-----
R
-----
V
D
M
T
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
A
Q
-
I
A
-
V
Q
A
S
L
T
G
H
L
-
V
M
S
--
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
D
M
--
G
I
E
P
------------
F
L
I
S
S
S
L
L
G
--
V
L
A
Q
R
L
V
R
-
T
L
C
P
D
C
K
E
P
Y
------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
46.50
29%
-87
- C2 -
3JVV
3
PILT_PSEAE
A:
[126-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
T
G
P
T
G
S
G
K
-
S
T
T
L
A
A
M
L
D
Y
L
N
N
T
K
Y
--
H
--
H
--
I
L
T
I
E
D
P
I
E
F
V
H
E
S
K
K
C
L
V
N
Q
R
E
--
V
H
-----
R
-----
D
T
L
G
F
S
E
A
L
R
S
A
L
R
E
D
P
D
I
I
L
V
G
E
M
R
D
L
E
T
-
I
-
R
L
---
A
L
T
A
A
E
T
G
H
L
V
F
G
T
L
H
T
T
S
A
A
K
T
I
D
R
V
V
D
V
FP
A
E
E
K
A
M
V
R
S
M
L
S
E
S
L
Q
S
V
I
S
Q
T
L
I
K
--
K
R
V
A
A
H
E
I
-
M
I
G
T
P
A
I
R
N
L
------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
46.42
31%
-91
- C2 -
4PHT
2
?
B:
[257-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
--
S
N
E
--
R
--
N
--
I
L
T
V
E
D
P
I
E
F
D
I
D
G
-
I
G
Q
T
--
Q
V
--
N
P
-----
K
-----
V
D
M
T
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
-
A
-
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
--
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
D
M
--
G
I
E
P
F
L
I
S
S
S
L
L
G
V
L
A
Q
R
L
V
R
T
L
C
Q
--
D
C
K
E
P
Y
E
A
-
D
K
E
Q
R
K
L
F
D
A
------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
46.25
31%
-91
- C2 -
4KSR
-
GSPE_VIBCH
A:
[162-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
--
S
S
E
--
R
--
N
--
I
L
T
V
E
D
P
I
E
F
D
I
D
G
-
I
G
Q
T
--
Q
V
--
N
P
-----
R
-----
V
D
M
T
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
-
A
-
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
--
T
L
H
T
N
T
A
V
G
A
V
T
R
L
R
D
M
--
G
I
E
P
F
L
I
S
S
S
L
L
G
V
L
A
Q
R
L
V
R
T
L
C
P
--
D
C
K
E
P
Y
E
A
-
D
K
E
Q
R
K
L
F
E
P
------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
45.89
31%
-92
- C2 -
4PHT
2
?
A:
[257-370]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
T
G
P
T
G
S
G
K
S
T
T
L
Y
A
G
L
Q
E
L
N
--
S
N
E
--
R
--
N
--
I
L
T
V
E
D
P
I
E
F
D
I
D
G
-
I
G
Q
T
--
Q
V
--
N
P
-----
K
-----
V
D
M
T
F
A
R
G
L
R
A
I
L
R
Q
D
P
D
V
V
M
V
G
E
I
R
D
L
E
T
-
A
-
Q
I
A
V
Q
A
S
L
T
G
H
L
-
V
M
S
--
T
L
H
T
N
T
A
V
G
A
I
T
R
L
R
D
M
--
G
I
E
P
F
L
I
S
S
S
L
L
G
V
L
A
Q
R
L
V
R
T
L
C
Q
--
D
C
K
E
P
Y
E
A
-
D
K
E
Q
R
K
L
F
A
L
------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
45.61
30%
-66
- C2 -
4IHQ
5
?
A:
[192-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
V
D
A
S
L
P
D
--
G
-
S
R
V
N
F
V
Y
G
-
V
D
I
S
R
R
-
G
S
N
L
T
V
R
K
F
S
R
V
----
P
T
S
I
T
Q
L
I
M
F
G
T
---------------
L
S
S
M
-----------------
M
A
A
Y
--
I
W
T
M
L
-
D
E
---
G
M
N
L
F
V
C
G
E
T
A
S
G
K
-
T
T
T
L
N
A
I
T
A
F
I
--
P
P
N
--
L
--
K
--
I
V
T
I
E
D
T
P
E
L
T
V
P
H
S
N
W
V
A
--
E
V
--
T
R
E
TGG-
E
-----
G
T
I
K
L
F
D
L
L
K
A
A
L
R
Q
R
P
N
Y
I
L
V
G
A
I
R
D
K
E
G
-
N
-
V
A
-
F
Q
A
M
Q
T
G
H
-
S
V
M
A
--
T
F
H
A
A
N
I
T
T
L
I
Q
R
L
T
G
Y
--
P
I
E
V
P
K
S
Y
I
N
N
L
N
I
A
L
F
Q
T
A
L
Y
D
K
K
--
G
N
L
I
R
R
V
V
-
E
V
D
E
I
I
D
I
D
P
------------------------------------------------------------------------------------------------------------