@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0495: (2015-12-15 )
MTNEAINQQPQTEAAFNPQQFINNLQVAFIKVDNVVASFDPNQKPIVDKNDRDNRQAFEKISQLREEFANKAIKNPTKKNQYFSSFISKSNDLIDKDNLIDTGSSIKSFQKFGTQRYQIFMNWVSHQNDPSKINTQKIRGFMENIIQPPISDDKEKAEFLRSAKQAFAGIIIGNQIRSDQKFMGVFDESLKERQEAEKNGEPNGDPTGGDWLDIFLSFVFNKKQSSDLKETLNQEPVPHVQPDVATTTTDIQSLPPEARDLLDERGNFSKFTLGDMNMLDVEGVADIDPNYKFNQLLIHNNALSSVLMGSHNGIEPEKVSLLYGNNGGPEARHDWNATVGYKNQRGDNVATLINVHMKNGSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIQNKVDFMEFLAQNNAKLDNLSKKEKEKFQNEIEDFQKDSKAYLDALGNDHIAFVSKKDKKHLALVAEFGNGELSYTLKDYGKKADKALDREAKTTLQGSLKHDGVMFVDYSNFKYTNASKSPDKGVGATNGVSHLEAGFSKVAVFNLPNLNNLAITSVVRQDLEDKLIAKGLSPQEANKLVKDFLSSNKELVGKALNFNKAVAEAKNTGNYDEVKQAQKDLEKSLKKRERLEKDVAKNLESKSGNKNKMEAKSQANSQKDEIFALINKEANRDARAIAYAQNLKGIKRELSDKLENINKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSIKDVIINQKITDKVDNLNQAVSVAKATGDFSGVEQALADLKNFSKEQLAQQAQKNEDFNTGKNSALYQSVKNGVNGTLVGNGLSKAEATTLSKNFSDIKKELNAKLGNFNNNNNNGLENSTEPIYTQVAKKVKAKIDRLDQIASGLGDVGQAASFLLKRHDKVDDLSKVGLSANHEPIYATIDDLGGPFPLKRHDKVDDLSKVGLSREQKLTQKIDNLNQAVSEAKASHFDNLDQMIDKLKDSTKKNVVNLYVESAKKVPTSLSAKLDNYATNSHTRINSNVKNGTINEKATGMLTQKNSEWLKLVNDKIVAHNVGSAPLSAYDKIGFNQKNMKDYSDSFKFSTRLSNAVKDIKSGFVQFLTNIFSMGSYSLMKASVEHGVKNTNTKGGFQKS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.---------------......120..-.....130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400..---------.....410.....--..420.......430.......440.......450-----.........460...-....470....--...480.......490..---.....500.......510.-......520....--...530.......540----...----------....550.......560.....-..570..--------.......--580.......590.----......600..-.....---------610.......620..-.....630.......640.......650---.......660.......670.......-680.......690.......700........---710..-.....720..-..-...730..--...----..740.......750.......760........770.......780.......790.......800.-......810.......820..-.....830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTNEAINQQPQTEAAF
N
P
Q
Q
F
INNL
Q
V
A
F
I
K
V
D
N
V
V
ASFDPNQKPIVDKNDRD
N
R
Q
A
F
E
K
I
S
Q
L
R
E
E
F
A
N
K
AIKNP
T
K
K
N
Q
Y
F
S
S
F
I
SKSNDLIDKDNLIDT
G
S
S
I
K
S
F
Q
K
FG---------------
T
Q
R
Y
Q
I
F
M
N
W
V
-SHQNDPSKI
N
T
Q
K
I
R
G
F
M
E
N
IIQPPISD
D
K
E
K
A
E
F
L
R
S
A
K
Q
A
F
A
G
I
I
IGNQIRS
D
Q
K
F
M
G
V
F
D
E
S
L
K
E
R
Q
E
A
EKNGEPNGDPTG
G
D
W
L
D
I
F
L
S
F
V
FNKKQ
S
S
D
L
K
E
T
LNQEPVPHVQPDVATTTT
D
I
QSLP
P
E
A
R
D
L
L
D
ERGNFSKFTLGDM
N
M
L
DVEGVADIDPNYK
F
N
Q
L
L
I
HN
N
A
L
S
S
V
L
MGSHNGIEP
E
K
V
S
L
L
Y
GNNGGPEARHDWNATVGYKNQRGD
N
V
A
T
L
I
N
V
H
MKNG
S
G
L
V
I
AGGEKGINNP
S
F
Y
L
Y
KEDQLTG
S
Q
RAL
S
Q
E
E
I
Q
N
K
V
D
F
M
---------
E
F
L
A
QNNAKLDNL--
S
K
K
E
K
E
K
F
Q
N
E
I
E
D
F
Q
K
D
S
K
A
Y
L
D
A
LGND
H
I
A
F
-------VSKKDK
K
H
L
A
L
V
A
EF-GNG
E
L
S
Y
T
L
K
D
--YG
K
K
A
D
K
A
L
D
R
E
A
K
T
T
LQ---GSLKHD
G
V
M
F
V
DYSN
F
K
YT-NASKSPDKGVGAT--N
G
V
S
H
L
E
A
GF
S
K
V
A
V
F----NLP----------NL
N
N
L
A
I
T
S
V
V
R
Q
D
L
E
D
K
L
I
AK-GL
S
--
P
Q
--------
E
A
N
K
L
V
K
--
D
F
L
SS
N
K
E
L
V
G
K
AL----NF
N
K
A
V
AEAKN-TG
N
Y
D
---------
E
V
K
Q
A
Q
K
D
L
E
K
S
L
K
K
-
R
E
R
L
E
K
D
V
A
K
N
L
E
SKSGNKN
K
M
E
A
K
SQA---NSQ
K
D
E
I
F
A
L
I
NKEANRD
A
R
A
I
A
Y
A
Q
N
-
L
K
G
I
K
R
E
L
S
D
K
L
E
N
I
N
K
D
L
K
D
F
-
S
K
S
F
D
E
F
K---NGKNK-
D
F
S
K
A
E
E
T
L
K
-
A
L
-
K
G
S
V
K
DLG--I
N
P
----
E
W
I
S
K
V
E
N
L
N
A
A
L
N
E
FKNGKNK
D
-
F
S
K
V
T
Q
A
K
S
D
L
E
N
S
I
K
D
V
IINQ
K
I
T
D
K
VD
N
L
N
Q
A
V
S
V
A
K
ATG
D
-
F
S
G
V
E
Q
A
L
A
D
L
K
NF
S
K
E
Q
L
A
Q
-
Q
A
QKNEDFNTGK
N
S
A
L
Y
Q
S
V
K
NGVN
G
T
L
VGNGLSK
A
E
A
T
T
LSK
N
F
S
D
I
K
K
E
L
N
A
KLGNFNNNNNNGLENST
E
P
I
Y
T
Q
V
A
K
K
V
K
A
K
I
D
R
L
D
Q
I
A
S
G
LG
D
V
G
Q
A
A
S
F
L
L
K
RHDKV
D
D
L
S
K
VGLSANHE
P
I
Y
A
T
I
D
DLGGPFPLKRHDKV
D
D
L
S
K
VGL
S
R
E
Q
K
L
T
Q
K
I
D
N
L
N
Q
A
V
S
E
A
K
A
S
H
FD
N
L
D
Q
M
I
D
K
L
K
D
S
T
KK
N
V
V
N
L
Y
V
E
S
A
KKVP
T
S
L
S
A
K
L
DNYATNSH
T
R
INSNVKNGTINEKAT
G
M
LTQKN
S
E
W
L
K
L
VND
K
I
V
AHNVGSA
P
L
S
A
Y
D
KIGFN
Q
K
N
M
K
D
YSDSF
K
F
S
T
R
L
S
N
A
V
K
D
I
K
S
G
F
V
Q
F
L
T
N
I
F
S
MG
S
Y
S
L
M
K
A
S
V
EHGVKNTNTKGGFQKS
2
PsiBlast_PDB
95.50
88%
-65
- C3 -
4DVY
-
CAGA_HELPY
P:
[24-824]
------------------
Q
Q
F
I
N
N
L
Q
V
A
F
I
K
V
D
N
V
V
A
S
F
D
P
D
Q
K
P
I
V
D
K
N
D
R
D
N
R
Q
A
F
D
G
I
S
Q
L
R
E
E
Y
S
N
K
A
I
K
N
P
T
K
K
N
Q
Y
F
S
D
F
I
D
K
S
N
D
L
I
N
K
D
N
L
I
D
V
E
S
S
T
K
S
F
Q
K
F
G
---------------
D
Q
R
Y
Q
I
F
T
S
W
V
-
S
M
Q
K
D
P
S
K
I
N
T
R
S
I
R
N
F
M
E
N
I
I
Q
P
P
I
P
D
D
K
E
K
A
E
F
L
K
S
A
K
Q
S
F
A
G
I
I
I
G
N
Q
I
R
T
D
Q
K
F
M
G
V
F
D
E
S
L
K
E
R
Q
E
A
E
K
N
G
----
G
P
T
G
G
D
W
L
D
I
F
L
S
F
I
F
---------------------------------------------------------------------------------
A
L
S
S
V
L
M
G
S
H
N
G
I
E
--
K
V
S
L
L
Y
A
G
N
G
G
F
G
D
K
H
D
W
N
A
T
V
G
Y
K
-----
N
V
A
T
L
I
N
V
H
M
K
N
G
S
G
L
V
I
A
G
G
E
K
G
I
N
N
P
S
F
Y
L
Y
K
E
D
Q
L
T
G
S
Q
R
A
L
S
Q
E
E
I
R
N
K
V
D
F
M
---------
E
F
L
A
Q
N
N
T
K
L
D
N
L
--
S
E
K
E
K
E
K
F
Q
N
E
I
E
D
F
Q
K
D
S
K
A
Y
L
D
A
L
G
N
D
R
I
A
F
-------
V
S
K
K
D
T
K
H
S
A
L
I
T
E
F
-
N
N
G
D
L
S
Y
T
L
K
D
--
Y
------------
N
V
T
L
Q
---
G
S
L
K
H
D
G
V
M
F
V
D
Y
S
------------------------------
F
N
K
V
A
V
F
----
N
L
P
----------
D
L
N
N
L
A
I
T
S
F
V
R
R
N
L
E
N
K
L
T
A
K
-
G
L
S
--
L
Q
--------
E
A
N
K
L
I
K
--
D
F
L
S
S
N
K
E
L
A
G
K
A
L
----
N
F
N
K
A
V
A
E
A
K
S
-
T
G
N
Y
D
---------
E
V
K
K
A
Q
K
D
L
E
K
S
L
R
K
-
R
E
H
L
E
K
E
V
E
K
K
L
E
S
K
S
---
N
K
M
E
A
K
A
Q
A
---
N
S
Q
K
D
E
I
F
A
L
I
N
K
E
A
N
R
D
A
R
A
I
A
Y
T
Q
N
-
L
K
G
I
K
R
E
L
S
D
K
L
E
K
I
S
K
D
L
K
D
F
-
S
K
S
F
D
E
F
K
--------------
E
E
T
L
K
-
A
L
-
K
G
S
V
K
D
L
G
--
I
N
P
----
E
W
I
S
K
V
E
N
L
N
A
A
L
N
E
F
K
N
------
F
S
K
V
T
Q
A
K
S
D
L
E
N
S
V
K
D
V
I
I
N
Q
K
V
T
D
K
V
D
N
L
N
Q
A
V
S
V
A
K
A
M
G
D
-
F
S
R
V
E
Q
V
L
A
D
L
K
N
F
S
K
E
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.77
87%
-51
- C3 -
4G0H
-
CAGA_HELPY
A:
[308-822]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
S
H
N
G
I
---
K
V
S
L
L
Y
A
G
N
G
G
F
G
D
K
H
D
W
N
A
T
V
G
Y
K
-----
N
V
A
T
L
I
N
V
H
M
K
N
G
S
G
L
V
I
A
G
G
E
K
G
I
N
N
P
S
F
Y
L
Y
K
E
D
Q
L
T
G
S
Q
R
A
L
S
Q
E
E
I
R
N
K
V
D
F
M
---------
E
F
L
A
Q
N
N
T
K
L
D
N
L
--
S
E
K
E
K
E
K
F
Q
N
E
I
E
D
F
Q
K
D
S
K
A
Y
L
D
A
L
G
N
D
R
I
A
F
-------
V
S
K
K
D
T
K
H
S
A
L
I
T
E
F
-
N
N
G
D
L
S
Y
T
L
K
D
--
Y
-----------
K
N
V
T
L
Q
---
G
S
L
K
H
D
G
V
M
F
V
D
Y
S
N
----------------------------
G
F
N
K
V
A
V
F
----
N
L
P
----------
D
L
N
N
L
A
I
T
S
F
V
R
R
N
L
E
N
K
L
T
A
K
-
G
L
S
--
L
Q
--------
E
A
N
K
L
I
K
--
D
F
L
S
S
N
K
E
L
A
G
K
A
L
----
N
F
N
K
A
V
A
E
A
K
S
-
T
G
N
Y
D
---------
E
V
K
K
A
Q
K
D
L
E
K
S
L
R
K
-
R
E
H
L
E
K
E
V
E
K
K
L
E
S
K
S
--
K
N
K
M
E
A
K
A
Q
A
---
N
S
Q
K
D
E
I
F
A
L
I
N
K
E
A
N
R
D
A
R
A
I
A
Y
T
Q
N
-
L
K
G
I
K
R
E
L
S
D
K
L
E
K
I
S
K
D
L
K
D
F
-
S
K
S
---------------
F
S
K
A
E
E
T
L
K
-
A
L
-
K
G
S
V
K
D
L
G
--
I
-
P
----
E
W
I
S
K
V
E
N
L
N
A
A
L
N
E
F
K
N
--------
K
V
T
Q
A
K
S
D
L
E
N
S
V
K
D
V
I
I
N
Q
K
V
T
D
K
V
D
N
L
N
Q
A
V
S
V
A
K
A
M
G
D
-
F
S
R
V
E
Q
V
L
A
D
L
K
N
F
S
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
73.74
89%
-49
- C3 -
4DVZ
-
CAGA_HELPY
A:
[308-829]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
S
H
N
G
----
K
V
S
L
L
Y
A
G
D
-----
K
H
D
W
N
A
T
V
G
Y
K
----
D
N
V
A
T
L
I
N
V
H
M
K
N
G
S
G
L
V
I
A
G
G
E
K
G
I
N
N
P
S
F
Y
L
Y
K
E
D
Q
L
T
G
S
Q
R
A
L
S
Q
E
E
I
R
N
K
V
D
F
M
---------
E
F
L
A
Q
N
N
T
K
L
D
N
L
--
S
E
K
E
K
E
K
F
Q
N
E
I
E
D
F
Q
K
D
S
K
A
Y
L
D
A
L
G
N
D
R
I
A
F
-------
V
S
K
K
D
T
K
H
S
A
L
I
T
E
F
-
N
N
G
D
L
S
Y
T
L
K
D
------------
Y
E
K
N
V
T
L
Q
---
G
S
L
K
H
D
G
V
M
F
V
D
Y
S
F
------------------------------
N
K
V
A
V
F
----
N
L
P
----------
D
L
N
N
L
A
I
T
S
F
V
R
R
N
L
E
N
K
L
T
A
K
-
G
L
S
--
L
Q
--------
E
A
N
K
L
I
K
--
D
F
L
S
S
N
K
E
L
A
G
K
A
L
----
N
F
N
K
A
V
A
E
A
K
S
-
T
G
N
Y
D
---------
E
V
K
K
A
Q
K
D
L
E
K
S
L
R
K
-
R
E
H
L
E
K
E
V
E
K
K
L
E
S
K
S
G
N
K
K
-----
A
Q
A
---
N
S
Q
K
D
E
I
F
A
L
I
N
K
E
A
N
R
D
A
R
A
I
A
Y
T
Q
N
-
L
K
G
I
K
R
E
L
S
D
K
L
E
K
I
S
K
D
L
K
D
F
-
S
K
S
F
D
E
F
K
---
N
------
F
S
K
A
E
E
T
L
K
-
A
L
-
K
G
S
V
K
D
L
G
--
I
N
P
----
E
W
I
S
K
V
E
N
L
N
A
A
L
N
E
F
K
N
G
---
D
-
F
S
K
V
T
Q
A
K
S
D
L
E
N
S
V
K
D
V
I
I
N
Q
K
V
T
D
K
V
D
N
L
N
Q
A
V
S
V
A
K
A
M
G
D
-
F
S
R
V
E
Q
V
L
A
D
L
K
N
F
S
K
E
Q
L
A
Q
-
Q
A
Q
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.47
91%
-51
- C3 -
4DVZ
-
CAGA_HELPY
A:
[308-829]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
G
S
H
N
G
----
K
V
S
L
L
Y
A
G
-----
D
K
H
D
W
N
A
T
V
G
Y
K
D
----
N
V
A
T
L
I
N
V
H
M
K
N
G
S
G
L
V
I
A
G
G
E
K
G
I
N
N
P
S
F
Y
L
Y
K
E
D
Q
L
T
G
S
Q
R
A
L
S
Q
E
E
I
R
N
K
V
D
F
M
---------
E
F
L
A
Q
N
N
T
K
L
D
N
L
--
S
E
K
E
K
E
K
F
Q
N
E
I
E
D
F
Q
K
D
S
K
A
Y
L
D
A
L
G
N
D
R
I
A
F
-------
V
S
K
K
D
T
K
H
S
A
L
I
T
E
F
-
N
N
G
D
L
S
Y
T
L
K
D
--
Y
----------
E
K
N
V
T
L
Q
---
G
S
L
K
H
D
G
V
M
F
V
D
Y
S
------------------------------
F
N
K
V
A
V
F
----
N
L
P
----------
D
L
N
N
L
A
I
T
S
F
V
R
R
N
L
E
N
K
L
T
A
K
-
G
L
S
--
L
Q
--------
E
A
N
K
L
I
K
--
D
F
L
S
S
N
K
E
L
A
G
K
A
L
----
N
F
N
K
A
V
A
E
A
K
S
-
T
G
N
Y
D
---------
E
V
K
K
A
Q
K
D
L
E
K
S
L
R
K
-
R
E
H
L
E
K
E
V
E
K
K
L
E
S
K
S
G
N
K
-----
K
A
Q
A
---
N
S
Q
K
D
E
I
F
A
L
I
N
K
E
A
N
R
D
A
R
A
I
A
Y
T
Q
N
-
L
K
G
I
K
R
E
L
S
D
K
L
E
K
I
S
K
D
L
K
D
F
-
S
K
S
F
D
E
F
K
---
N
------
F
S
K
A
E
E
T
L
K
-
A
L
-
K
G
S
V
K
D
L
G
--
I
N
P
----
E
W
I
S
K
V
E
N
L
N
A
A
L
N
E
F
K
N
G
---
D
-
F
S
K
V
T
Q
A
K
S
D
L
E
N
S
V
K
D
V
I
I
N
Q
K
V
T
D
K
V
D
N
L
N
Q
A
V
S
V
A
K
A
M
G
D
-
F
S
R
V
E
Q
V
L
A
D
L
K
N
F
S
K
E
Q
L
A
Q
-
Q
A
Q
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
51.89
83%
-52
- C3 -
4IRV
1
CAGA_HELPY
A:
[10-207]
------------------
Q
Q
F
I
N
N
L
Q
V
A
F
I
K
V
D
N
V
V
A
S
F
D
P
D
Q
K
P
I
V
D
K
N
D
R
D
N
R
Q
A
F
D
G
I
S
Q
L
R
E
E
Y
S
N
K
A
I
K
N
P
T
K
K
N
Q
Y
F
S
D
F
I
D
K
S
N
D
L
I
N
K
D
N
L
I
D
V
E
S
S
T
K
S
F
Q
K
F
G
---------------
D
Q
R
Y
Q
I
F
T
S
W
V
-
S
H
Q
K
D
P
S
K
I
N
T
R
S
I
R
N
F
M
E
N
I
I
Q
P
P
I
P
D
D
K
E
K
A
E
F
L
K
S
A
K
Q
S
F
A
G
I
I
I
G
N
Q
I
R
T
D
Q
K
F
M
G
V
F
D
E
S
L
K
E
R
Q
E
A
E
K
-----
G
G
P
T
G
G
D
W
L
D
I
F
L
S
F
I
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
42.09
18%
215
* C4 *
1X8Y
-
LMNA_HUMAN
A:
[313-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
A
K
E
A
K
L
R
D
L
E
D
S
-
L
A
R
E
R
D
T
S
R
R
L
L
A
E
K
--
E
R
E
M
A
E
M
R
A
R
M
---
Q
Q
Q
L
D
E
Y
Q
E
L
L
D
I
K
L
A
L
D
M
E
I
H
A
Y
R
K
L
-
L
E
G
E
E
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
41.43
35%
85
- C3 -
1LQ7
-
?
A:
[7-66]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
E
K
V
K
-
A
L
-
E
E
K
V
K
A
L
G
--
G
G
G
RI
E
-
E
L
K
K
K
W
E
E
L
K
K
K
I
E
E
L
G
--
G
G
G
E
-
V
K
K
V
E
E
E
V
K
K
L
E
E
E
I
K
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
39.93
11%
54
- C3 -
4UY3
-
EZRA_STAA1
A:
[1-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
S
N
K
R
Q
----
I
I
E
----------
K
A
I
E
R
K
N
E
I
E
T
L
P
F
D
Q
N
L
A
Q
L
S
-
K
L
N
--
L
K
G-------
E
T
K
T
K
Y
D
--
A
M
K
K
D
N
V
E
S
T
N
K
Y
L
AP
V
E
E
K
I
H
N
A
E
A
L
L
D
-
K
F
S
F
N
---------
A
S
Q
S
E
I
D
D
A
N
E
L
M
D
S
-
Y
E
Q
S
Y
Q
Q
Q
L
E
D
V
N
-------
E
I
I
A
L
Y
K
D
---
N
D
E
L
Y
D
K
C
K
V
D
Y
R
E
M
K
R
D
V
L
A
N
----------
R
H
Q
F
G
E
A
A
S
L
L
E
T
E
I
E
K
F
-
E
P
R
L
E
Q
Y
E
---
V
L
K
A
D
G
N
Y
V
Q
A
H
N
H
I
A
-
A
L
-
N
E
Q
M
K
Q
L
R
--
S
Y
M
----
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
37.55
12%
56
- C4 -
3NA7
3
?
A:
[1-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
--
S
N
--------
T
H
L
K
Q
L
I
--
E
I
S
H
L
D
K
E
I
D
S
L
E
P
----
L
I
R
E
K
R
K
D
L
D
K
A
L
N
D
K
E
---------
A
K
N
K
A
I
L
N
L
E
E
E
K
L
A
-
L
K
L
Q
V
S
K
N
E
Q
T
L
Q
D
T
N
A
K
I
A
S
I
Q
K
K
M
S
E
IKS
E
R
E
L
R
S
L
N
I
E
E
D
I
A
K
E
R
S
N
Q
A
N
R
E
I
E
N
-
L
Q
N
E
I
K
R
K
S
E
K
Q
E
D
L
K
K
E
M
L
E
L
-
E
K
L
A
L
E
L
E
---
S
L
V
E
N
-
E
V
K
N
I
K
E
T
Q
Q
-
I
I
-
F
K
K
K
E
D
L
V
E
K
T
E
P
----
K
I
Y
S
F
Y
E
R
I
R
R
W
A
K
N
T
S
I
V
T
I
K
K
--
Q
A
C
G
G
C
F
I
R
L
N
D
K
I
Y
T
E
V
L
T
S
G
D
M
I
T
C
P
Y
C
G
R
I
L
Y
A
E
G
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
37.54
20%
443
- C3 -
3CVE
-
HOME1_RAT
A:
[294-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
I
R
N
-
K
D
L
E
G
---------
Q
L
S
E
M
E
Q
R
L
E
K
S
Q
S
E
-
Q
D
A
F
R
S
N
L
K
T
L
L
E
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
36.55
20%
435
- C3 -
3CVF
-
HOME3_HUMAN
A:
[300-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
T
R
N
-
A
E
L
E
H
---------
Q
L
R
A
M
E
R
S
L
E
E
A
R
A
E
-
R
E
R
A
R
A
E
V
G
R
A
A
Q
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
35.95
22%
120
- C4 -
2A3D
-
?
A:
[1-73]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
S
W
A
E
F
K
---------
Q
R
L
A
A
I
K
T
R
L
Q
A
L
GG
S
E
A
E
L
A
A
F
E
K
E
I
A
A
F
E
S
E
L
Q
A
Y
-
K
G
K
G
N
P
E
V
E
A
-------
L
R
K
E
A
A
A
I
R
D
E
L
Q
A
Y
-
R
H
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
34.56
10%
42
- C4 -
2HVG
8
?
A:
[21-478]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
K
N
I
S
P
I
D
G
R
Y
K
K
A
C
G
E
L
S
A
F
F
S
E
H
A
L
I
K
H
R
I
I
V
E
V
R
W
L
---------
L
F
L
N
E
E
E
L
F
F
E
K
V
--
T
D
H
S
V
E
V
L
N
Q
I
A
T
N
I
T
D
S
D
I
A
R
V
K
A
I
E
H
D
V
K
A
V
E
Y
F
V
K
E
K
L
K
N
S
K
R
E
D
L
L
K
I
K
E
Y
V
H
Y
L
C
T
S
E
D
I
N
N
V
A
Y
A
T
C
L
K
A
C
L
N
D
V
V
I
P
C
L
E
K
I
M
L
K
L
K
D
L
A
V
E
Y
S
H
V
P
L
L
S
R
T
-
H
G
Q
P
A
S
S
T
T
F
G
K
E
M
A
N
F
Y
A
R
I
H
H
H
V
G
V
I
R
R
V
----
K
V
C
A
K
FNGAVGNF
N
A
H
K
V
A
S
K
D
T
D
W
V
N
T
I
G
L
F
L
K
K
-
H
F
N
--
L
T
YSIYCTQI
Q
D
H
D
Y
I
C
--
E
L
C
D
G
L
A
R
A
N
G
T
L
I
----
D
L
C
V
D
I
W
L
Y
I
S
-
N
N
L
L
K
LKSSTMPHK
V
N
P
I
D
F
E
N
A
E
G
N
L
H
I
-
A
N
A
F
F
K
L
F
S
S
K
L
P
T
S
R
L
Q
R
D
L
S
D
S
T
V
L
R
---
N
I
G
S
S
L
A
Y
C
L
I
A
Y
K
S
V
L
K
G
L
N
K
I
D
I
-
D
-
R
R
N
L
E
E
E
L
N
Q
N
W
S
T
L
A
E
P
I
Q
I
V
M
K
R
H
N
Y
V
D
A
---
Y
E
E
L
K
-
Q
F
T
R
G
K
V
I
D
Q
-
K
I
M
Q
E
F
I
K
T
K
C
--
A
F
L
----
P
Q
D
V
V
D
Q
L
L
E
L
T
P
A
T
Y
T
G
Y
A
D
Y
L
-
A
K
N
V
E
R
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
34.31
9%
40
- C4 -
2W6D
16
BDLP_NOSP7
A:
[2-695]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
Q
V
A
T
D
R
F
I
Q
D
L
E
R
V
A
Q
V
R
S
E
M
S
V
C
L
N
K
L
A
E
T
I
N
K
A
E
L
A
G
D
S
S
S
G
K
L
S
L
E
R
D
I
E
D
I
T
I
A
S
K
N
L
Q
Q
G
V
F
R
L
L
V
L
G
D
M
K
R
G
K
S
T
F
L
N
A
L
I
G
E
N
L
L
P
S
T
A
V
L
T
V
L
R
Y
G
P
E
K
K
V
T
I
H
F
N
D
G
K
S
P
Q
Q
L
D
F
Q
N
F
K
Y
K
Y
T
I
D
P
A
E
A
K
K
L
E
Q
E
K
K
Q
A
F
P
D
V
D
Y
A
V
V
E
Y
PL
T
L
L
Q
K
G
I
E
I
V
D
S
P
--
G
L
N
D
T
E
A
R
N
E
L
S
L
G
Y
V
N
N
C
H
A
I
L
F
V
M
R
A
S
Q
--
P
-------
C
T
L
G
E
R
R
Y
L
E
N
Y
I
K
G
-
R
G
L
T
V
F
F
L
V
N
A
--
W
D
Q
V
R
E
S
L
I
D
P
D
D
V
E
E
L
Q
---
A
S
E
N
R
L
R
Q
V
F
N
A
N
L
A
E
Y
C
T
V
E
G
Q
N
I
Y
D
E
R
V
F
E
L
--
S
S
I
Q
A
L
R
R
R
L
K
N
P
Q
A
D
LDGT
G
F
P
----------
K
F
M
D
S
L
N
T
F
L
T
R
E
R
A
I
A
E
L
R
Q
V
-
R
T
L
--
A
R
--------
L
A
C
N
H
T
R
--
E
A
V
A
R
R
I
P
L
L
E
Q
D
V
-----
N
E
L
K
K
R
I
D
S
V
-
E
P
E
F
N
---------
K
L
T
G
I
R
D
E
F
Q
K
E
I
I
N
T
R
D
T
Q
A
R
T
I
S
E
S
F
R
S
Y
V
L
N
L
G
N
T
F
E
N
D
F
L
---
R
Y
Q
P
E
L
N
L
F
D
F
L
S
S
G
K
R
E
A
F
N
A
A
L
Q
K
A
F
E
Q
Y
I
T
D
K
S
A
A
W
T
L
T
A
E
K
D
I
N
A
A
-
F
K
E
L
S
R
S
A
---
S
Q
Y
G
A
-
S
Y
N
Q
I
T
D
Q
I
T
-
E
K
-
L
T
G
K
D
V
E
D
--
N
S
P
----
G
W
A
K
W
A
M
G
L
L
S
L
S
K
G
N
L
A
G
F
A
L
A
-
G
A
G
F
D
W
K
N
I
L
L
N
Y
F
T
V
I
G
I
G
G
I
I
T
A
V
T
G
I
L
L
G
P
I
G
F
A
L
L
G
L
G
V
G
F
L
Q
A
D
Q
A
R
R
E
L
V
K
T
A
K
K
E
L
V
K
-
H
L
P
Q
V
A
H
E
Q
S
Q
V
V
Y
N
A
V
K
E
C
F
D
S
Y
E
R
E
V
S
K
R
I
N
D
D
I
V
S
R
K
S
E
L
D
N
L
V
K
Q
K
Q
T
R
E
I
N
R
E
S
E
F
N
R
L
K
N
L
Q
E
D
V
I
A
Q
L
Q
K
I
E
A
A
Y
S
N
L
L
A
Y
Y
S
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
33.75
22%
262
- C3 -
3CSX
1
?
A:
[29-78]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
A
G
Q
M
K
M
-
D
L
-
H
D
L
A
E
G
L
P
--
T
D
Y
EN
L
V
E
T
A
E
K
T
Y
E
I
F
R
E
L
D
Q
L
K
------------
K
K
L
N
I
W
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
32.69
11%
69
- C4 -
3G9G
-
SYP1_YEAST
A:
[1-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
E
Q
R
T
K
Y
A
D
S
I
LT--
T
K
S
P
Y
E
A
T
E
T
I
-
R
I
R
L
S
---------
Q
V
K
L
L
N
K
D
F
Y
L
L
F
K
E
-
L
A
N
L
K
R
N
Y
A
Q
Q
L
R
K
I
I
A
E
N
E
D
I
T
K
I
L
N
A
---
Q
M
I
E
S
N
V
L
T
P
Q
E
M
S
A
F
R
F
N
S
L
G
E
L
R
N
V
-
W
D
T
V
I
E
E
L
K
S
D
L
K
S
S
T
E
Y
Y
N
T
L
-
D
Q
Q
V
V
R
E
L
K
E
S
V
E
N
N
T
-
S
W
R
E
S
K
D
L
H
S
-
K
L
-
S
K
N
A
A
S
I
E
--
H
Y
S
----
K
N
N
E
N
S
S
H
L
E
E
A
R
R
Q
W
D
Q
Q
S
P
Y
L
-
F
E
L
F
E
T
I
D
Y
N
R
L
D
T
L
K
N
C
M
L
R
F
Q
T
S
F
S
D
Y
L
L
N
T
T
K
E
C
E
T
V
M
T
K
-
F
L
A
F
E
-
P
Q
S
E
I
D
R
F
A
K
D
A
S
Q
Y
-
N
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
31.64
11%
94
- C4 -
2OEX
-
PDC6I_HUMAN
A:
[361-702]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
----------
V
Q
Q
S
L
A
A
Y
N
Q
R
K
A
D
L
V
N
R
S
I
A
Q
M
R
E
A
--
T
T
--------
L
A
N
G
V
L
A
S
L
N
L
P
A
A
I
E
D
V
S
G
D
T
V
P
Q
--
S
I
L
T
K
S
R
S
V
I
E
-
Q
G
G
I
Q
---------
T
V
D
Q
L
I
K
E
L
P
E
L
L
Q
R
-
N
R
E
I
L
D
E
S
L
R
L
L
D
E
E
E
A
T
D
N
D
L
R
A
K
F
K
E
---
R
W
Q
R
T
P
S
N
E
L
Y
K
P
L
R
A
E
G
T
N
F
R
T
V
L
D
K
-
A
V
Q
A
D
G
Q
V
K
E
C
Y
Q
S
H
R
D
T
I
V
L
L
-
C
K
P
E
P
E
L
N
---
A
A
-----
I
P
S
A
N
P
A
K
T
M
Q
G
-
S
E
V
V
N
V
L
K
--
S
L
L
----
S
N
L
D
E
V
K
K
E
R
E
G
L
E
N
D
L
K
S
V
N
F
D
M
T
S
K
F
L
T
A
L
A
Q
D
G
V
I
N
E
E
A
L
S
V
T
E
L
D
R
V
Y
G
G
L
T
T
K
V
Q
E
S
L
K
K
-------
Q
E
G
L
L
K
N
I
Q
V
S
H
Q
E
F
S
K
M
K
Q
S
N
N
E
A
N
L
R
E
E
V
L
K
N
L
A
T
A
Y
D
N
F
V
E
L
V
A
N
L
K
E
G
T
K
F
Y
N
E
L
T
E
I
L
V
R
F
Q
N
K
C
S
D
I
V
F
A
R
K
T
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
30.90
27%
648
- C3 -
1J2J
1
B:
[14-37]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
L
L
K
S
-
S
H
P
E
D
L
R
--------
A
A
N
K
L
I
K
--
E
M
V
Q
E
D
Q
K
R
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
28.43
25%
103
- C3 -
4YDQ
1
SYP_PLAF7
A:
[39-134]
------------------------------------------------------
R
P
A
A
Y
Y
I
W
E
C
V
Q
A
F
F
N
K
E
I
K
K
L
N
V
E
N
S
Y
F
P
L
F
V
T
K
N
K
L
E
K
E
K
N
H
--
G
F
S
P
E
V
A
W
V
T
K
Y
G
DSNLP
E
E
I
A
I
R
PTS
E
T
I
M
Y
S
V
F
P
K
W
I
R
S
Y
R
D
L
P
L
K
L
N
Q
W
N
T
V
V
R
W
E
F
K
Q
P
T
P
F
I
R
T
R
E
F
L
W
Q
E
G
H
T
A
H
K
N
E
E
E
A
V
K
L
V
F
D
I
L
D
L
Y
R
R
W
Y
E
E
Y
L
A
V
P
I
I
K
G
I
K
S
E
G
E
K
F
G
G
A
N
F
T
S
T
A
E
A
F
I
S
E
N
G
R
A
I
Q
A
A
T
S
H
Y
L
G
T
N
F
A
K
M
F
K
I
E
F
E
D
E
N
E
V
K
Q
Y
V
H
Q
T
S
W
G
C
T
T
R
S
I
G
I
M
I
M
T
H
G
D
D
K
G
L
V
L
P
P
N
V
S
K
Y
K
V
V
I
V
P
I
F
Y
K
T
T
D
E
N
A
I
H
S
Y
C
K
D
I
E
K
I
L
K
N
A
Q
I
N
C
V
Y
D
D
R
A
S
Y
S
P
G
Y
K
F
N
H
W
E
L
R
G
I
P
I
R
I
E
V
G
P
K
D
L
Q
N
N
S
C
V
I
V
R
R
D
N
N
E
K
C
N
V
K
K
E
S
V
L
L
E
T
Q
Q
M
L
V
D
I
H
K
N
L
F
L
K
A
K
K
K
L
D
---------
D
S
I
V
Q
V
T
S
F
S
E
V
M
--
N
A
L
N
K
K
K
M
V
L
A
P
W
C
E
D
I
A
T
E
E
E
I
K
K
E
T
Q
R
L
S
L
N
-------
Q
S
G
A
M
K
P
L
C
I
P
L
D
Q
P
-
P
M
P
P
N
M
K
C
F
W
S
--
G
K
P
A
K
R
W
C
L
F
G
R
S
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
28.02
40%
581
* C3 *
1M45
-
B:
[1-25]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
S
Q
A
I
K
Y
L
Q
N
N
I
K
G
F
I
I
R
Q
R
V
N
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------