@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0505: (2015-12-15 )
MRRIVVTGMGMINSLGLNKEDSFLAIAKGECGIKNIESFDANAFPVRIAGEITDFDPTEVMNPKDVKKAGRFIQLALKATREAMKDSGILDAHNRCPEELANRMGVSSGSGIGGLGNIEANSIFCFEKGPRKVNPFFITSALVNMIGGFTSIEFGIKGPNLSSVTACAAGTHAIIEAVKTILLNGADRMLVVGAESTICPVGIGGFASIKALSTRNDDPKKASRPFDKDRNGFVMGEGAGALVLEEYESAKKRGAKIYAEFAGYGESGDANHITAPAPEGEGAFRAMKMALEMAKVEVGYVNAHGTSTHYNDWYESIALKNVFGSKEKVPPVSSTKGQIGHCLGAAGALEAVISIMAMNQGILPPTINQETPDPECDLDYIPNTAREKQVNAVMSNSFGFGGTNGVVIFKKA
Atome Classification :
(36 SA)
.........10........20........30...-------....--.40-------.------------....------...-------50.------.-------....--------..60........70........80........90........-100...--.....110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210..-.-....220.......230.......240.......250.......260.......270.......280.......290---....---.---..300.......310.......320..--..--...330.......340.......350.......360.......370.....-..380.-....-..---390.---......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
R
I
V
V
TGM
G
M
I
N
SLGLNKED
S
F
L
A
I
AKGECGIK-------N
I
E
S--FDA-------N------------A
F
P
V
------
R
I
A-------GEI------T-------DFDP--------TEVM
N
P
K
D
V
K
K
A
G
R
F
I
Q
L
A
L
K
A
T
R
E
A
M
KDSGIL
D
A
H
NR
C
P
E
E
-
L
-
A
N
RM--GVSSGSGIGGLGNIEA
N
S
I
F
C
FEKGPRKV
N
P
F
F
I
T
S
A
L
V
N
MIGGF
T
S
I
E
F
GIKGPNL
S
S
V
T
A
CAA
G
T
H
A
I
I
E
A
V
K
T
I
L
LNGA
D
R
M
L
V
VGAESTICPVGIGGF
A
S
I
K
A
LST-R-NDDPKKASRPFDKDRN
G
F
V
MGEGA
G
A
L
V
L
E
E
Y
E
S
A
K
KRG
A
K
I
Y
A
E
FAGYGESGDANHITAPAPEG
E
G
A
F
R
A
M
K
M
A
L
E
---
M
A
K
V
---
E
---
V
G
Y
V
NAHGTST
H
Y
N
D
W
Y
E
S
I
A
L
K
N
VFG--SK--EKVPPVSSTKGQ
I
G
H
CLG
A
A
G
A
L
E
A
V
I
S
I
M
A
MNQGILPPTINQETPDPECD-LDYIPN-T
A
R
E
-
K
Q
---
V
N
A
V
---MSNSFGFGGTN
G
V
V
I
F
KKA
27
PsiBlast_CBE
97.80
49%
-66
- C4 -
4JRM
3
FABF_VIBCH
B:
[7-416]
-
R
R
V
V
V
T
G
M
G
M
L
S
P
V
G
N
T
V
E
S
S
W
K
A
L
L
A
G
Q
S
G
I
V
-------
N
I
E
H
--
F
D
T
-------
T
------------
N
F
S
T
------
R
F
A
-------
G
L
V
------
K
-------
G
F
D
C
--------
E
Q
Y
M
S
K
K
D
A
R
K
M
D
L
F
I
Q
Y
G
I
A
A
G
I
Q
A
L
E
D
S
G
L
-----
E
V
N
E
E
-
N
-
A
A
R
I
--
G
V
A
I
G
S
G
I
G
G
L
E
L
I
E
T
G
H
Q
A
L
I
E
K
G
P
R
K
V
S
P
F
F
V
P
S
T
I
V
N
M
I
A
G
N
L
S
I
M
R
G
L
R
G
P
N
I
A
I
S
T
A
C
T
T
G
L
H
N
I
G
H
A
A
R
M
I
A
Y
G
D
A
D
A
M
V
A
G
G
A
E
K
A
S
T
P
L
G
M
A
G
F
G
A
A
K
A
L
S
T
-
R
-
N
D
E
P
Q
K
A
S
R
P
W
D
K
D
R
D
G
F
V
L
G
D
G
A
G
I
M
V
L
E
E
Y
E
H
A
K
A
R
G
A
K
I
Y
A
E
V
V
G
F
G
M
S
G
D
A
Y
H
M
T
S
P
S
E
D
G
S
G
G
A
L
A
M
E
A
A
M
R
---
D
A
G
V
TGE
Q
---
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
V
A
E
V
K
G
I
K
R
A
L
G
E-
A
G
--
T
K
Q
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
S
V
E
A
I
I
T
V
M
S
L
V
D
Q
M
V
P
P
T
I
N
L
D
N
P
E
E
G
L
G
-
V
D
L
V
P
H
-
V
A
R
K
V
E
S
---
M
E
Y
A
---
M
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
R
M
34
PsiBlast_CBE
97.38
48%
-66
- C4 -
3G11
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
9
PsiBlast_PDB
97.35
49%
-65
- C4 -
4JRM
1
FABF_VIBCH
D:
[7-416]
-
R
R
V
V
V
T
G
M
G
M
L
S
P
V
G
N
T
V
E
S
S
W
K
A
L
L
A
G
Q
S
G
I
V
-------
N
I
E
H
--
F
D
T
-------
T
------------
N
F
S
T
------
R
F
A
-------
G
L
V
------
K
-------
G
F
D
C
--------
E
Q
Y
M
S
K
K
D
A
R
K
M
D
L
F
I
Q
Y
G
I
A
A
G
I
Q
A
L
E
D
S
G
L
-----
E
V
N
E
E
-
N
-
A
A
R
I
--
G
V
A
I
G
S
G
I
G
G
L
E
L
I
E
T
G
H
Q
A
L
I
E
K
G
P
R
K
V
S
P
F
F
V
P
S
T
I
V
N
M
I
A
G
N
L
S
I
M
R
G
L
R
G
P
N
I
A
I
S
T
A
C
T
T
G
L
H
N
I
G
H
A
A
R
M
I
A
Y
G
D
A
D
A
M
V
A
G
G
A
E
K
A
S
T
P
L
G
M
A
G
F
G
A
A
K
A
L
S
T
-
R
-
N
D
E
P
Q
K
A
S
R
P
W
D
K
D
R
D
G
F
V
L
G
D
G
A
G
I
M
V
L
E
E
Y
E
H
A
K
A
R
G
A
K
I
Y
A
E
V
V
G
F
G
M
S
G
D
A
Y
H
M
T
S
P
S
E
D
G
S
G
G
A
L
A
M
E
A
A
M
R
---
D
A
G
V
TGE
Q
---
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
V
A
E
V
K
G
I
K
R
A
L
G
E-
A
G
--
T
K
Q
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
S
V
E
A
I
I
T
V
M
S
L
V
D
Q
M
V
P
P
T
I
N
L
D
N
P
E
E
G
L
G
-
V
D
L
V
P
H
-
V
A
R
K
V
E
S
---
M
E
Y
A
---
M
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
R
M
22
PsiBlast_CBE
97.12
49%
-65
- C4 -
4LS8
5
FABF_BACSU
B:
[17-423]
-
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
-------
P
I
T
R
--
V
D
A
-------
E
------------
E
Y
P
A
------
K
V
A
-------
A
E
L
------
K
-------
D
F
N
V
--------
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
-----
N
I
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
---
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
---
D
A
G
I
APE
E
---
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
--
E
H
--
A
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
-
L
D
Y
V
P
D
-
E
A
R
R
-
Q
E
---
L
N
Y
V
---
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
4
PsiBlast_PDB
97.12
49%
-66
- C4 -
4LS8
9
FABF_BACSU
A:
[17-423]
-
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
-------
P
I
T
R
--
V
D
A
-------
E
------------
E
Y
P
A
------
K
V
A
-------
A
E
L
------
K
-------
D
F
N
V
--------
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
-----
N
I
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
---
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
---
D
A
G
I
APE
E
---
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
--
E
H
--
A
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
-
L
D
Y
V
P
D
-
E
A
R
R
-
Q
E
---
L
N
Y
V
---
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
16
PsiBlast_PDB
96.95
49%
-65
- C4 -
2GFW
-
FABF_ECOLI
A:
[3-411]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
C
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
29
PsiBlast_CBE
96.93
49%
-65
- C4 -
4JRH
2
FABF_VIBCH
B:
[7-416]
-
R
R
V
V
V
T
G
M
G
M
L
S
P
V
G
N
T
V
E
S
S
W
K
A
L
L
A
G
Q
S
G
I
V
-------
N
I
E
H
--
F
D
T
-------
T
------------
N
F
S
T
------
R
F
A
-------
G
L
V
------
K
-------
G
F
D
C
--------
E
Q
Y
M
S
K
K
D
A
R
K
M
D
L
F
I
Q
Y
G
I
A
A
G
I
Q
A
L
E
D
S
G
L
-----
E
V
N
E
E
-
N
-
A
A
R
I
--
G
V
A
I
G
S
G
I
G
G
L
E
L
I
E
T
G
H
Q
A
L
I
E
K
G
P
R
K
V
S
P
F
F
V
P
S
T
I
V
N
M
I
A
G
N
L
S
I
M
R
G
L
R
G
P
N
I
A
I
S
T
A
C
T
T
G
L
H
N
I
G
H
A
A
R
M
I
A
Y
G
D
A
D
A
M
V
A
G
G
A
E
K
A
S
T
P
L
G
M
A
G
F
G
A
A
K
A
L
S
T
-
R
-
N
D
E
P
Q
K
A
S
R
P
W
D
K
D
R
D
G
F
V
L
G
D
G
A
G
I
M
V
L
E
E
Y
E
H
A
K
A
R
G
A
K
I
Y
A
E
V
V
G
F
G
M
S
G
D
A
Y
H
M
T
S
P
S
E
D
G
S
G
G
A
L
A
M
E
A
A
M
R
---
D
A
G
V
TGE
Q
---
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
V
A
E
V
K
G
I
K
R
A
L
G
E
-
A
G
--
T
K
Q
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
S
V
E
A
I
I
T
V
M
S
L
V
D
Q
M
V
P
P
T
I
N
L
D
N
P
E
E
G
L
G
-
V
D
L
V
P
H
-
V
A
R
K
V
E
S
---
M
E
Y
A
---
M
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
R
M
5
PsiBlast_PDB
96.72
49%
-64
- C4 -
4LS6
4
FABF_BACSU
A:
[17-423]
-
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
-------
P
I
T
R
--
V
D
A
-------
E
------------
E
Y
P
A
------
K
V
A
-------
A
E
L
------
K
-------
D
F
N
V
--------
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
-----
N
I
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
F
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
---
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
---
D
A
G
I
APE
E
---
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
--
E
H
--
A
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
-
L
D
Y
V
P
D
-
E
A
R
R
-
Q
E
---
L
N
Y
V
---
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
25
PsiBlast_CBE
96.71
49%
-64
- C4 -
4LS6
6
FABF_BACSU
B:
[17-423]
-
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
-------
P
I
T
R
--
V
D
A
-------
E
------------
E
Y
P
A
------
K
V
A
-------
A
E
L
------
K
-------
D
F
N
V
--------
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
-----
N
I
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
F
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
---
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
---
D
A
G
I
APE
E
---
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
--
E
H
--
A
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
-
L
D
Y
V
P
D
-
E
A
R
R
-
Q
E
---
L
N
Y
V
---
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
28
PsiBlast_CBE
96.62
49%
-66
- C4 -
4JRM
1
FABF_VIBCH
A:
[7-416]
-
R
R
V
V
V
T
G
M
G
M
L
S
P
V
G
N
T
V
E
S
S
W
K
A
L
L
A
G
Q
S
G
I
V
-------
N
I
E
H
--
F
D
T
-------
T
------------
N
F
S
T
------
R
F
A
-------
G
L
V
------
K
-------
G
F
D
C
--------
E
Q
Y
M
S
K
K
D
A
R
K
M
D
L
F
I
Q
Y
G
I
A
A
G
I
Q
A
L
E
D
S
G
L
-----
E
V
N
E
E
-
N
-
A
A
R
I
--
G
V
A
I
G
S
G
I
G
G
L
E
L
I
E
T
G
H
Q
A
L
I
E
K
G
P
R
K
V
S
P
F
F
V
P
S
T
I
V
N
M
I
A
G
N
L
S
I
M
R
G
L
R
G
P
N
I
A
I
S
T
A
C
T
T
G
L
H
N
I
G
H
A
A
R
M
I
A
Y
G
D
A
D
A
M
V
A
G
G
A
E
K
A
S
T
P
L
G
M
A
G
F
G
A
A
K
A
L
S
T
-
R
-
N
D
E
P
Q
K
A
S
R
P
W
D
K
D
R
D
G
F
V
L
G
D
G
A
G
I
M
V
L
E
E
Y
E
H
A
K
A
R
G
A
K
I
Y
A
E
V
V
G
F
G
M
S
G
D
A
Y
H
M
T
S
P
S
E
D
G
S
G
G
A
L
A
M
E
A
A
M
R
---
D
A
G
V
TGE
Q
---
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
V
A
E
V
K
G
I
K
R
A
L
G
E
-
A
G
--
T
K
Q
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
S
V
E
A
I
I
T
V
M
S
L
V
D
Q
M
V
P
P
T
I
N
L
D
N
P
E
E
G
L
G
-
V
D
L
V
P
H
-
V
A
R
K
V
E
S
---
M
E
Y
A
---
M
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
R
M
2
PsiBlast_PDB
96.62
49%
-65
- C4 -
4LS5
5
FABF_BACSU
A:
[17-423]
-
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
-------
P
I
T
R
--
V
D
A
-------
E
------------
E
Y
P
A
------
K
V
A
-------
A
E
L
------
K
-------
D
F
N
V
--------
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
-----
N
I
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
---
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
---
D
A
G
I
APE
E
---
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
--
E
H
--
A
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
-
L
D
Y
V
P
D
-
E
A
R
R
-
Q
E
---
L
N
Y
V
---
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
15
PsiBlast_PDB
96.49
49%
-65
- C4 -
1KAS
-
FABF_ECOLI
A:
[3-411]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
C
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
20
PsiBlast_PDB
96.37
48%
-65
- C4 -
3HO2
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
24
PsiBlast_CBE
96.27
49%
-65
- C4 -
4LS5
4
FABF_BACSU
B:
[17-423]
-
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
-------
P
I
T
R
--
V
D
A
-------
E
------------
E
Y
P
A
------
K
V
A
-------
A
E
L
------
K
-------
D
F
N
V
--------
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
-----
N
I
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
---
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
---
D
A
G
I
APE
E
---
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
--
E
H
--
A
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
-
L
D
Y
V
P
D
-
E
A
R
R
-
Q
E
---
L
N
Y
V
---
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
32
PsiBlast_CBE
96.24
48%
-64
- C4 -
3I8P
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
35
PsiBlast_CBE
96.23
48%
-65
- C4 -
3G0Y
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
3
PsiBlast_PDB
96.21
49%
-65
- C4 -
4LS7
6
FABF_BACSU
A:
[17-423]
-
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
-------
P
I
T
R
--
V
D
A
-------
E
------------
E
Y
P
A
------
K
V
A
-------
A
E
L
------
K
-------
D
F
N
V
--------
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
-----
N
I
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
---
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
---
D
A
G
I
APE
E
---
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
--
E
H
--
A
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
-
L
D
Y
V
P
D
-
E
A
R
R
-
Q
E
---
L
N
Y
V
---
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
21
PsiBlast_CBE
96.20
49%
-64
- C4 -
1J3N
1
?
B:
[1-407]
M
R
R
V
V
V
T
G
L
G
A
L
T
P
I
G
V
G
Q
E
A
F
H
K
A
Q
L
A
G
K
S
G
V
R
-------
P
I
T
R
--
F
D
A
-------
S
------------
A
L
P
V
------
R
I
A
-------
A
E
V
--------------
D
V
D
P
--------
G
A
Y
L
D
R
K
E
L
R
R
L
D
R
F
V
Q
Y
A
L
I
A
A
Q
L
A
L
E
D
A
G
L
------
K
P
E
D
-
L
D
P
E
R
V
--
G
T
L
V
G
T
G
I
G
G
M
E
T
W
E
A
Q
S
R
V
F
L
E
R
G
P
N
R
I
S
P
F
F
I
P
M
M
I
A
N
M
A
S
A
H
I
A
M
R
Y
G
F
T
G
P
S
S
T
V
V
T
A
C
A
T
G
A
D
A
L
G
S
A
L
R
M
I
Q
L
G
E
A
D
L
V
L
A
G
G
T
E
A
A
I
T
P
M
A
I
G
A
F
A
V
M
R
A
L
S
T
-
R
-
N
E
E
P
E
K
A
S
R
P
F
T
L
S
R
D
G
F
V
M
G
E
G
A
G
V
L
V
L
E
A
Y
E
H
A
K
K
R
G
A
R
I
Y
A
E
L
V
G
F
G
R
S
A
D
A
H
H
I
T
E
P
H
P
E
G
K
G
A
A
L
A
M
A
R
A
L
K
DAG
I
A
P
E
---
Q
---
V
G
Y
I
N
A
H
G
T
S
T
P
V
G
D
R
A
E
V
L
A
I
K
R
V
F
G
--
D
H
--
A
K
R
L
M
V
S
S
T
K
S
M
I
G
H
L
L
G
A
A
G
A
V
E
A
I
A
T
V
Q
A
L
Y
H
G
V
I
P
P
T
I
N
L
E
D
P
D
P
E
L
D
-
L
D
F
V
P
E
-
P
-
R
E
-
A
K
---
V
D
Y
A
---
L
S
N
S
F
A
F
G
G
H
N
A
V
L
A
F
K
R
V
116
HHSearch
96.00
46%
-67
- C4 -
3KZU
2
?
A:
[9-426]
M
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
R
-------
R
V
T
E
--
F
E
V
-------
D
------------
D
L
A
C
------
Q
I
A
CRIPVGD
G
T
N
------
G
-------
T
F
N
P
--------
D
L
H
M
D
P
K
E
Q
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
G
W
H
P
E
N
----
D
E
-
D
-
Q
V
R
T
--
G
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
T
-
E
R
N
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
---
R
A
G
I
VPD
E
---
I
D
Y
I
N
A
H
G
T
S
T
M
-
A
D
T
I
E
L
G
A
V
E
R
V
V
G
--
E
A
--
A
A
K
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
A
Q
T
R
-
I
D
L
V
P
H
-
K
P
R
E
-
R
K
---
I
D
V
A
---
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
Y
19
PsiBlast_PDB
95.90
48%
-61
- C4 -
3HNZ
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
17
PsiBlast_PDB
95.85
48%
-63
- C4 -
2GFY
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
C
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
A
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
33
PsiBlast_CBE
95.83
48%
-65
- C4 -
3HO9
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
23
PsiBlast_CBE
95.76
49%
-63
- C4 -
4LS7
6
FABF_BACSU
B:
[17-423]
-
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
-------
P
I
T
R
--
V
D
A
-------
E
------------
E
Y
P
A
------
K
V
A
-------
A
E
L
------
K
-------
D
F
N
V
--------
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
-----
N
I
T
D
E
-
I
-
A
P
R
V
--
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
T
---
N
P
D
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
---
D
A
G
I
APE
E
---
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
--
E
H
--
A
H
K
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
-
L
D
Y
V
P
D
-
E
A
R
R
-
Q
E
---
L
N
Y
V
---
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
14
PsiBlast_PDB
95.71
49%
-66
- C4 -
1B3N
1
FABF_ECOLI
A:
[3-411]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
C
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
36
PsiBlast_CBE
95.49
48%
-63
- C4 -
2GFX
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
I
S
-------
L
I
D
H
--
F
D
T
-------
S
------------
A
Y
A
T
------
K
F
A
-------
G
L
V
------
K
-------
D
F
N
C
--------
E
D
I
I
S
R
K
E
Q
R
K
M
D
A
F
I
Q
Y
G
I
V
A
G
V
Q
A
M
Q
D
S
G
L
-----
E
I
T
E
E
-
N
-
A
T
R
I
--
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
-
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
P
P
E
N
G
A
G
A
A
L
A
M
A
N
A
L
R
---
D
A
G
I
---
E
ASQ
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
--
E
A
--
A
S
R
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
G
C
D
-
L
D
F
V
P
H
-
E
A
R
Q
-
V
S
G--
M
E
Y
T
---
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
I
44
PsiBlast_CBE
95.43
43%
-62
- C4 -
3KZU
4
?
B:
[9-425]
M
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
R
-------
R
V
T
E
--
F
E
V
-------
D
------------
D
L
A
C
------
Q
I
A
-------
C
R
I
------
P
VGDGTNG
T
F
N
P
--------
D
L
H
M
D
P
K
E
Q
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
G
W
---
H
P
E
N
D
E
D
-
Q
-
V
R
T
G
--
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
-
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
T
E
R
-
N
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
---
R
A
G
I
VPD
E
---
I
D
Y
I
N
A
H
G
T
S
T
-
M
A
D
T
I
E
L
G
A
V
E
R
V
V
G
--
E
A
--
A
A
K
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
A
Q
T
R
-
I
D
L
V
P
H
-
K
P
R
E
-
R
K
---
I
D
V
A
---
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
Y
45
PsiBlast_CBE
94.80
43%
-63
- C4 -
3KZU
2
?
A:
[9-425]
M
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
R
-------
R
V
T
E
--
F
E
V
-------
D
------------
D
L
A
C
------
Q
I
A
-------
C
R
I
------
P
VGDGTNG
T
F
N
P
--------
D
L
H
M
D
P
K
E
Q
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
G
W
---
H
P
E
N
D
E
D
-
Q
-
V
R
T
G
--
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
-
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
T
E
R
-
N
D
D
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
---
R
A
G
I
VPD
E
---
I
D
Y
I
N
A
H
G
T
S
T
-
M
A
D
T
I
E
L
G
A
V
E
R
V
V
G
--
E
A
--
A
A
K
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
A
Q
T
R
-
I
D
L
V
P
H
-
K
P
R
E
-
R
K
---
I
D
V
A
---
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
Y
37
PsiBlast_CBE
94.46
44%
-66
- C4 -
4JGA
2
?
B:
[16-432]
-
K
R
V
V
I
T
G
L
G
L
V
T
P
V
G
L
N
V
N
S
S
W
K
N
I
V
D
G
V
S
G
I
K
-------
T
I
T
E
--
F
D
T
-------
S
------------
K
L
A
C
------
K
I
A
-------
G
L
I
------
D
-------
N
S
E
K
DGFKLENF
T
Q
A
D
D
I
N
R
L
S
K
M
D
K
F
I
H
Y
G
V
A
A
A
T
E
A
V
E
D
S
G
W
L
P
D
D
----
E
K
-
S
-
R
D
R
T
--
G
L
I
L
G
S
G
I
G
G
L
K
M
I
E
D
T
S
I
K
L
Y
Q
E
N
N
G
K
V
S
P
F
F
I
P
A
S
L
I
N
L
L
S
G
L
V
S
I
K
Y
G
F
S
G
P
N
Q
T
A
V
T
A
C
S
T
G
A
H
A
I
G
D
A
M
R
M
I
K
H
G
Y
A
D
V
M
I
A
G
G
A
E
A
P
V
T
P
V
G
V
A
G
F
V
A
A
R
A
L
C
T
-
K
Y
N
D
N
P
K
K
A
S
R
P
W
D
K
D
R
S
G
F
V
M
G
E
G
A
G
V
V
V
L
E
E
Y
E
H
A
L
N
R
G
A
K
V
Y
G
E
V
I
G
Y
G
S
T
G
D
A
Y
H
M
T
A
P
H
P
E
G
R
G
A
Y
R
A
M
R
D
A
M
L
---
D
A
T
I
---
T
PDM
I
D
Y
I
N
A
H
G
T
S
T
T
L
G
D
G
I
E
L
A
A
V
Q
K
L
F
L
--
E
A
--
N
P
K
V
L
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
S
V
E
F
I
F
S
A
L
A
I
R
D
Q
I
A
P
P
T
L
N
L
D
T
P
M
D
E
V
N
-
I
D
L
V
A
L
-
K
A
K
K
-
T
K
---
I
D
Y
V
---
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
I
K
S
I
38
PsiBlast_CBE
94.26
44%
-67
- C4 -
4JGA
3
?
A:
[16-432]
-
K
R
V
V
I
T
G
L
G
L
V
T
P
V
G
L
N
V
N
S
S
W
K
N
I
V
D
G
V
S
G
I
K
-------
T
I
T
E
--
F
D
T
-------
S
------------
K
L
A
C
------
K
I
A
-------
G
L
I
------
D
-------
N
S
E
K
DGFKLENF
T
Q
A
D
D
I
N
R
L
S
K
M
D
K
F
I
H
Y
G
V
A
A
A
T
E
A
V
E
D
S
G
W
L
P
D
D
----
E
K
-
S
-
R
D
R
T
--
G
L
I
L
G
S
G
I
G
G
L
K
M
I
E
D
T
S
I
K
L
Y
Q
E
N
N
G
K
V
S
P
F
F
I
P
A
S
L
I
N
L
L
S
G
L
V
S
I
K
Y
G
F
S
G
P
N
Q
T
A
V
T
A
C
S
T
G
A
H
A
I
G
D
A
M
R
M
I
K
H
G
Y
A
D
V
M
I
A
G
G
A
E
A
P
V
T
P
V
G
V
A
G
F
V
A
A
R
A
L
C
T
-
K
Y
N
D
N
P
K
K
A
S
R
P
W
D
K
D
R
S
G
F
V
M
G
E
G
A
G
V
V
V
L
E
E
Y
E
H
A
L
N
R
G
A
K
V
Y
G
E
V
I
G
Y
G
S
T
G
D
A
Y
H
M
T
A
P
H
P
E
G
R
G
A
Y
R
A
M
R
D
A
M
L
---
D
A
T
I
---
T
PDM
I
D
Y
I
N
A
H
G
T
S
T
T
L
G
D
G
I
E
L
A
A
V
Q
K
L
F
L
--
E
A
--
N
P
K
V
L
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
S
V
E
F
I
F
S
A
L
A
I
R
D
Q
I
A
P
P
T
L
N
L
D
T
P
M
D
E
V
N
-
I
D
L
V
A
L
-
K
A
K
K
-
T
K
---
I
D
Y
V
---
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
I
K
S
I
128
HHSearch
93.53
46%
-63
- C4 -
2IX4
3
KASM_ARATH
A:
[1-430]
-
R
R
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
I
R
-------
G
L
T
L
DD
L
K
M
-------
K
SFD
E
E
T
K
L
Y
T
F
D
Q
L
S
S
------
K
V
A
-------
A
F
V
PYGSNP
G
-------
E
F
D
E
--------
A
L
W
---
L
N
S
K
A
V
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
E
W
L
P
T
E
----
E
E
-
E
-
K
E
R
T
--
G
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
T
K
F
-
N
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
P
P
E
D
G
K
G
A
V
L
A
M
T
R
A
L
R
---
Q
S
G
L
CPN
Q
---
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
--
E
H
A
T
S
G
T
L
A
F
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
P
I
F
D
-
K
R
F
M
P
L
T
T
S
K
K
-
M
L
---
V
R
T
A
---
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
A
S
I
119
HHSearch
92.80
43%
-62
- C4 -
2IWZ
3
OXSM_HUMAN
A:
[20-437]
H
R
R
V
V
I
T
G
I
G
L
V
T
P
L
G
V
G
T
H
L
V
W
D
R
L
I
G
G
E
S
G
I
V
-------
S
L
V
G
--
E
E
Y
-------
K
------------
S
I
P
C
S
V
A
A
Y
V
P
R
G
-------
S
D
E
------
G
-------
Q
F
N
E
--------
Q
N
F
V
S
K
S
D
I
K
S
M
S
S
P
T
I
M
A
I
G
A
A
E
L
A
M
K
D
S
G
W
H
P
Q
S
-----
E
A
D
-
Q
V
A
T
--
G
V
A
I
G
M
G
M
I
P
L
E
V
V
S
E
T
A
L
N
F
Q
T
K
G
Y
N
K
V
S
P
F
F
V
P
K
I
L
V
N
M
A
A
G
Q
V
S
I
R
Y
K
L
K
G
P
N
H
A
V
S
T
A
C
T
T
G
A
H
A
V
G
D
S
F
R
F
I
A
H
G
D
A
D
V
M
V
A
G
G
T
D
S
C
I
S
P
L
S
L
A
G
F
S
R
A
R
A
L
S
T
---
N
S
D
P
K
L
A
C
R
P
F
H
P
K
R
D
G
F
V
M
G
E
G
A
A
V
L
V
L
E
E
Y
E
H
A
V
Q
R
R
A
R
I
Y
A
E
V
L
G
Y
G
L
S
G
D
A
G
H
I
T
A
P
D
P
E
G
E
G
A
L
R
C
M
A
A
A
L
K
---
D
A
G
V
QPE
E
---
I
S
Y
I
N
A
H
A
T
S
T
P
L
G
D
A
A
E
N
K
A
I
K
H
L
F
K
--
D
H
--
A
Y
A
L
A
V
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
A
F
T
T
L
A
C
Y
Y
Q
K
L
P
P
T
L
N
L
D
C
S
E
P
E
F
D
-
L
N
Y
V
P
L
-
K
A
Q
E
-
W
K
T
E
K
R
F
I
G
---
L
T
N
S
F
G
F
G
G
T
N
A
T
L
C
I
A
G
L
54
PsiBlast_CBE
92.65
42%
-58
- C4 -
2IWZ
3
OXSM_HUMAN
A:
[21-433]
-
R
R
V
V
I
T
G
I
G
L
V
T
P
L
G
V
G
T
H
L
V
W
D
R
L
I
G
G
E
S
G
I
V
-------
S
L
V
G
--
E
E
Y
-------
K
------------
S
I
P
C
------
S
V
A
-------
A
Y
V
------
P
RGSDEG-
Q
F
N
E
--------
Q
N
F
V
S
K
S
D
I
K
S
M
S
S
P
T
I
M
A
I
G
A
A
E
L
A
M
K
D
S
G
W
H
------
P
Q
S
-
E
-
A
D
Q
V
A
T
G
V
A
I
G
M
G
M
I
P
L
E
V
V
S
E
T
A
L
N
F
Q
T
K
G
Y
N
K
V
S
P
F
F
V
P
K
I
L
V
N
M
A
A
G
Q
V
S
I
R
Y
K
L
K
G
P
N
H
A
V
S
T
A
C
T
T
G
A
H
A
V
G
D
S
F
R
F
I
A
H
G
D
A
D
V
M
V
A
G
G
T
D
S
C
I
S
P
L
S
L
A
G
F
S
R
A
R
A
L
S
T
---
N
S
D
P
K
L
A
C
R
P
F
H
P
K
R
D
G
F
V
M
G
E
G
A
A
V
L
V
L
E
E
Y
E
H
A
V
Q
R
R
A
R
I
Y
A
E
V
L
G
Y
G
L
S
G
D
A
G
H
I
T
A
P
D
P
E
G
E
G
A
L
R
C
M
A
A
A
L
K
---
D
A
G
V
QPE
E
---
I
S
Y
I
N
A
H
A
T
S
T
P
L
G
D
A
A
E
N
K
A
I
K
H
L
F
K
--
D
H
--
A
Y
A
L
A
V
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
A
F
T
T
L
A
C
Y
Y
Q
K
L
P
P
T
L
N
L
D
C
S
E
P
E
F
D
-
L
N
Y
V
P
L
-
K
A
Q
E
-
W
K
---
T
E
K
R
F
I
G
L
T
N
S
F
G
F
G
G
T
N
A
T
L
C
I
A
G
L
40
PsiBlast_CBE
92.42
42%
-64
- C4 -
2IX4
3
KASM_ARATH
A:
[1-428]
-
R
R
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
I
R
G
L
T
LDDL
K
M
K
S
--
F
D
E
E
T
K
L
Y
T
F
D
------------
Q
L
S
S
------
K
V
A
-------
A
F
V
------
P
YGSNPG-
E
F
D
E
--------
A
L
W
L
N
S
K
A
V
---
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
E
W
L
P
T
E
E
---
E
E
-
K
-
E
R
T
G
--
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
-
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
T
-
K
F
N
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
P
P
E
D
G
K
G
A
V
L
A
M
T
R
A
L
R
---
Q
S
G
L
CPN
Q
---
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
E
H
A
T
--
S
G
T
L
A
F
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
P
I
F
D
-
K
R
F
M
P
L
-
T
T
S
K
-
K
M
L--
V
R
T
A
---
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
A
S
I
39
PsiBlast_CBE
92.38
42%
-67
- C4 -
2IX4
3
KASM_ARATH
B:
[1-428]
-
R
R
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
I
R
GLTLDDL
K
M
K
S
--
F
D
E
ETKLYTF
D
------------
Q
L
S
S
------
K
V
A
-------
A
F
V
------
P
YGSNPG-
E
F
D
E
--------
A
L
W
L
N
S
K
A
V
---
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
E
W
L
P
T
E
E
---
E
E
-
K
-
E
R
T
G
--
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
-
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
T
-
K
F
N
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
P
P
E
D
G
K
G
A
V
L
A
M
T
R
A
L
R
---
Q
S
G
L
CPN
Q
---
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
EH
A
T
--
S
G
T
L
A
F
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
P
I
F
D
-
K
R
F
M
P
L
-
T
T
S
K
-
K
M
L--
V
R
T
A
---
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
A
S
I
53
PsiBlast_CBE
91.45
42%
-56
- C4 -
2IWZ
3
OXSM_HUMAN
B:
[21-433]
-
R
R
V
V
I
T
G
I
G
L
V
T
P
L
G
V
G
T
H
L
V
W
D
R
L
I
G
G
E
S
G
I
V
-------
S
L
V
G
--
E
E
Y
-------
K
------------
S
I
P
C
------
S
V
A
-------
A
Y
V
------
P
RGSDEG-
Q
F
N
E
--------
Q
N
F
V
S
K
S
D
I
K
S
M
S
S
P
T
I
M
A
I
G
A
A
E
L
A
M
K
D
S
G
W
H
------
P
Q
S
-
E
-
A
D
Q
V
AT
G
V
A
I
G
M
G
M
I
P
L
E
V
V
S
E
T
A
L
N
F
Q
T
K
G
Y
N
K
V
S
P
F
F
V
P
K
I
L
V
N
M
A
A
G
Q
V
S
I
R
Y
K
L
K
G
P
N
H
A
V
S
T
A
C
T
T
G
A
H
A
V
G
D
S
F
R
F
I
A
H
G
D
A
D
V
M
V
A
G
G
T
D
S
C
I
S
P
L
S
L
A
G
F
S
R
A
R
A
L
S
T
---
N
S
D
P
K
L
A
C
R
P
F
H
P
K
R
D
G
F
V
M
G
E
G
A
A
V
L
V
L
E
E
Y
E
H
A
V
Q
R
R
A
R
I
Y
A
E
V
L
G
Y
G
L
S
G
D
A
G
H
I
T
A
P
D
P
E
G
E
G
A
L
R
C
M
A
A
A
L
K
---
D
A
G
V
QPE
E
---
I
S
Y
I
N
A
H
A
T
S
T
P
L
G
D
A
A
E
N
K
A
I
K
H
L
F
K
--
D
H
--
A
Y
A
L
A
V
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
A
F
T
T
L
A
C
Y
Y
Q
K
L
P
P
T
L
N
L
D
C
S
E
P
E
F
D
-
L
N
Y
V
P
L
-
K
A
Q
E
-
W
K
---
T
E
K
R
FIG
L
T
N
S
F
G
F
G
G
T
N
A
T
L
C
I
A
G
L
112
HHSearch
88.80
36%
-59
- C4 -
3MQD
4
?
A:
[22-426]
M
R
R
V
V
V
T
G
M
G
I
V
S
S
I
G
S
N
T
E
E
V
T
A
S
L
R
E
A
K
S
G
I
S
-------
R
A
E
E
--
Y
A
E
-------
L
------------
G
F
R
C
------
Q
V
H
--------
G
A
------
P
-------
D
I
D
I
--------
E
S
L
V
D
R
R
A
M
R
F
H
G
R
G
T
A
W
N
H
I
A
M
D
Q
A
I
A
D
A
G
L
T
E
E
E
-----
V
-
S
-
N
E
R
T
--
G
I
I
M
G
S
G
G
P
S
T
R
T
I
V
D
S
A
D
I
T
R
E
K
G
P
K
R
V
G
P
F
A
V
P
K
A
M
S
S
T
A
S
A
T
L
A
T
F
F
K
I
K
G
I
N
Y
S
I
S
S
A
C
A
T
S
N
H
C
I
G
N
A
Y
E
M
I
Q
Y
G
K
Q
D
R
M
F
A
G
G
C
E
D
L
-
D
W
T
L
S
V
L
F
D
A
M
G
A
M
S
S
-
K
Y
N
D
T
P
S
T
A
S
R
A
Y
D
K
N
R
D
G
F
V
I
A
G
G
A
G
V
L
V
L
E
D
L
E
T
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
A
T
S
D
G
Y
D
M
V
A
P
--
S
G
E
G
A
I
R
C
M
K
M
A
L
S
---
T
V
T
S
---
K
---
I
D
Y
I
N
P
H
A
T
S
T
P
A
G
D
A
P
E
I
E
A
I
R
Q
I
F
G
--
A
G
--
D
V
C
P
P
I
A
A
T
K
S
L
T
G
H
S
L
G
A
T
G
V
Q
E
A
I
Y
S
L
L
M
M
Q
N
N
F
I
C
E
S
A
H
I
E
E
L
D
P
A
F
A
D
M
P
I
V
R
K
-
R
I
D
N
-
V
Q
---
L
N
T
V
---
L
S
N
S
F
G
F
G
G
T
N
A
T
L
V
F
Q
R
Y