@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0524: (2015-12-16 )
MPNRGVVLLDGQALAYNIEKDLKNKIQIITAQTHKRPKLAVILVGKDPASITYVNMKIKACQRVGMDFDLKTLKENITEAELLSLIKDYNTDQNISGILVQLPLPRSIDTKMILEAIDPNKDVDGFHPLNIGKLCTQKESFLPATPMGVMRLLEHYHIEIKGKDVAIIGASNIIGKPLSMLMLNAGASVSVCHILTKDISFYTKNADIVCVGVGKPDLIKASMLKKGAVVVDIGINHLNDGRIVGDVDFINAQKIAGFITPVPKGVGPMTIVSLLENTLIAFEKQQRKGF
Atome Classification :
(27 SA)
.........10........20........30-...-.-.-...40........50........60.....-...70........80........90........100..--..--.-..110.......120.......130..-..--.--.--.--140........150.......160.......170.......180.......190.--....--..200.......210.......220.......230.......240---.------.-.......250.......260.......270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPNR
G
V
V
L
LDGQ
A
L
A
Y
N
I
E
K
D
LKN
K
I
Q
I
I
T
A-QTH-K-R-
P
K
L
A
V
I
L
VGKDPA
S
I
T
Y
V
N
M
K
I
K
A
C
Q
R
VGM-DF
D
L
K
T
L
K
ENI
T
E
A
E
L
L
S
L
I
K
DYNTDQNI
S
G
I
L
V
QLPL--PR--S-I
D
T
K
M
I
L
E
AIDPNKDVDGFHPL
N
I
G
K
L
-CT--Q--K--E--S-FLPAT
P
M
G
V
M
R
L
L
E
H
Y
H
I
E
I
KG
K
D
V
A
I
I
GASNIIGK
P
L
S
M
L
M
LNAGASV
S
V
C
H
--
I
L
T
K--DI
S
F
YTKNA
D
I
V
C
V
GVGK
P
D
L
I
K
A
S
M
LKKG
A
V
V
V
D
I
GINHLND-----G------
R
-
I
V
GDVDFI
N
A
Q
K
I
A
G
F
ITPVPKGV
G
P
M
T
I
V
S
L
L
E
N
T
L
I
A
F
E
K
Q
Q
RKGF-
37
HHSearch
96.58
52%
-124
- C7 -
3P2O
2
FOLD_CAMJE
A:
[1-284]
--
S
N
A
M
T
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
S
--
K
G
-
I
-
E
-
S
C
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
-
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
--
P
D
--
H
-
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
-
N
L
--
G
--
L
E-
S
--
G
-
F
L
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
A
V
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
N
A
G
A
T
V
S
V
C
H
--
I
K
T
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
N
R
L
E
S
-----
G
------
K
-
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
K
S
A
K
N
R
L
-----
1
PsiBlast_PDB
95.08
53%
-128
- C7 -
3P2O
2
FOLD_CAMJE
A:
[6-277]
-------
L
L
D
G
K
A
L
S
A
K
I
K
E
E
L
K
E
K
N
Q
F
L
K
S
-
K
G
I
-
E
-
S
-
C
-
L
A
V
I
L
V
G
D
N
P
A
S
Q
T
Y
V
K
S
K
A
K
A
C
E
E
C
G
I
-
K
S
L
V
Y
H
L
N
E
N
I
T
Q
N
E
L
L
A
L
I
N
T
L
N
H
D
D
S
V
H
G
I
L
V
Q
L
P
L
--
P
D
--
H
-
I
C
K
D
L
I
L
E
S
I
I
S
S
K
D
V
D
G
F
H
P
I
N
V
G
Y
L
-
N
L
--
G
--
L
--
E
--
S
G
F
L
P
C
T
P
L
G
V
M
K
L
L
K
A
Y
E
I
D
L
E
G
K
D
A
V
I
I
G
A
S
N
I
V
G
R
P
M
A
T
M
L
L
N
A
G
A
T
V
S
V
C
H
--
I
K
T
K
--
D
L
S
L
Y
T
R
Q
A
D
L
I
I
V
A
A
G
C
V
N
L
L
R
S
D
M
V
K
E
G
V
I
V
V
D
V
G
I
N
R
L
E
S
-----
G
------
K
-
I
V
G
D
V
D
F
E
E
V
S
K
K
S
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
V
K
S
A
K
N
R
L
-----
36
HHSearch
92.22
47%
-122
- C7 -
3L07
4
FOLD_FRATT
A:
[3-284]
----
A
M
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
H
-
H
T
A
-
I
-
T
-
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
-
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
A
--
H
-
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
-
Q
L
--
R
--
D
K-
K
--
C
-
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
A
K
A
T
V
T
T
C
H
--
R
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
N
H
V
D
------
G
------
K
-
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
L
N
-----
24
PsiBlast_CBE
92.10
43%
-123
- C7 -
4B4U
7
?
B:
[24-300]
------
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
T
G
-
R
-
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
--
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
-
H
P
R
D
-----
G
------
G
-
G
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
----
23
PsiBlast_CBE
92.08
43%
-122
- C7 -
4B4V
3
?
B:
[24-300]
------
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
T
G
-
R
-
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
--
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
-
H
P
R
D
-----
G
------
G
-
G
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
----
40
HHSearch
91.82
47%
-116
- C7 -
1B0A
-
FOLD_ECOLI
A:
[2-284]
----
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
A
-
A
G
L
-
R
-
A
-
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
-
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
--
P
A
--
G
-
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
-
C
Q
--
R
--
A
--
P
--
R
-
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
L
A
G
C
T
T
T
V
T
H
--
R
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
N
R
L
E
N
-----
G
------
K
-
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
Q
A
C
V
E
Y
H
D
P
Q
D
-
56
Fugue
91.72
47%
-117
* C7 *
1B0A
-
FOLD_ECOLI
A:
[2-288]
----
A
A
K
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
A
-
A
G
--
L
-
R
A
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
-
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
--
P
A
---G
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
-
C
Q
RA
P
--------
R
-
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
L
A
G
C
T
T
T
V
T
H
--
R
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
N
R
L
E
N
-----
G
------
K
-
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
Q
A
C
V
E
Y
H
D
P
Q
D
E
22
PsiBlast_CBE
91.69
43%
-121
- C7 -
4B4W
3
?
B:
[24-300]
------
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
T
G
-
R
-
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
--
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
-
H
P
R
D
-----
G
------
G
-
G
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
----
21
PsiBlast_CBE
91.47
47%
-120
- C7 -
3L07
4
FOLD_FRATT
B:
[1-285]
--
S
N
A
M
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
H
-
H
T
A
-
I
-
T
-
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
-
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
A
--
H
-
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
L
R
--
D
--
K
--
K
--
C
-
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
A
K
A
T
V
T
T
C
H
--
R
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
N
H
V
-
D
-----
G
------
K
-
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
L
N
R
----
3
PsiBlast_PDB
91.41
47%
-122
- C7 -
3L07
4
FOLD_FRATT
A:
[3-284]
----
A
M
I
L
I
D
G
K
S
L
S
K
D
L
K
E
R
L
A
T
Q
V
Q
E
Y
K
H
-
H
T
A
-
I
-
T
-
P
K
L
V
A
I
I
V
G
N
D
P
A
S
K
T
Y
V
A
S
K
E
K
A
C
A
Q
V
G
I
-
D
S
Q
V
I
T
L
P
E
H
T
T
E
S
E
L
L
E
L
I
D
Q
L
N
N
D
S
S
V
H
A
I
L
V
Q
L
P
L
--
P
A
--
H
-
I
N
K
N
N
V
I
Y
S
I
K
P
E
K
D
V
D
G
F
H
P
T
N
V
G
R
L
Q
L
R
--
D
--
K
--
K
--
C
-
L
E
S
C
T
P
K
G
I
M
T
M
L
R
E
Y
G
I
K
T
E
G
A
Y
A
V
V
V
G
A
S
N
V
V
G
K
P
V
S
Q
L
L
L
N
A
K
A
T
V
T
T
C
H
--
R
F
T
T
--
D
L
K
S
H
T
T
K
A
D
I
L
I
V
A
V
G
K
P
N
F
I
T
A
D
M
V
K
E
G
A
V
V
I
D
V
G
I
N
H
V
-
D
-----
G
------
K
-
I
V
G
D
V
D
F
A
A
V
K
D
K
V
A
A
I
T
P
V
P
G
G
V
G
P
M
T
I
T
E
L
L
Y
N
T
F
Q
C
A
Q
E
L
N
-----
5
PsiBlast_PDB
91.26
43%
-121
- C7 -
4B4U
9
?
A:
[24-300]
------
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
T
G
-
R
-
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
--
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
-
H
P
R
D
-----
G
------
G
-
G
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
----
7
PsiBlast_PDB
90.98
43%
-119
- C7 -
4B4W
4
?
A:
[24-300]
------
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
T
G
-
R
-
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
--
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
-
H
P
R
D
-----
G
------
G
-
G
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
----
6
PsiBlast_PDB
90.95
43%
-120
- C7 -
4B4V
4
?
A:
[24-300]
------
L
V
L
D
G
R
A
L
A
K
Q
I
E
E
N
L
L
V
R
V
E
A
L
K
A
-
K
T
G
-
R
-
T
-
P
I
L
A
T
I
L
V
G
D
D
G
A
S
A
T
Y
V
R
M
K
G
N
A
C
R
R
V
G
M
-
D
S
L
K
I
E
L
P
Q
E
T
T
T
E
Q
L
L
A
E
I
E
K
L
N
A
N
P
D
V
H
G
I
L
L
Q
H
P
V
--
P
A
--
Q
-
I
D
E
R
A
C
F
D
A
I
S
L
A
K
D
V
D
G
V
T
C
L
G
F
G
R
M
-
A
M
--
G
--
E
--
A
--
A
-
Y
G
S
A
T
P
A
G
I
M
T
I
L
K
E
N
N
I
E
I
A
G
K
H
A
V
V
V
G
R
S
A
I
L
G
K
P
M
A
M
M
L
L
Q
A
N
A
T
V
T
I
C
H
--
S
R
T
Q
--
N
L
P
E
L
V
K
Q
A
D
I
I
V
G
A
V
G
K
A
E
L
I
Q
K
D
W
I
K
Q
G
A
V
V
V
D
A
G
F
-
H
P
R
D
-----
G
------
G
-
G
V
G
D
I
Q
L
Q
G
I
E
E
I
A
S
A
Y
T
P
V
P
G
G
V
G
P
M
T
I
T
T
L
I
R
Q
T
V
E
A
A
E
K
A
L
G
----
2
PsiBlast_PDB
90.59
48%
-121
- C7 -
1B0A
-
FOLD_ECOLI
A:
[5-278]
-------
I
I
D
G
K
T
I
A
Q
Q
V
R
S
E
V
A
Q
K
V
Q
A
R
I
A
-
A
G
L
-
R
-
A
-
P
G
L
A
V
V
L
V
G
S
N
P
A
S
Q
I
Y
V
A
S
K
R
K
A
C
E
E
V
G
F
-
V
S
R
S
Y
D
L
P
E
T
T
S
E
A
E
L
L
E
L
I
D
T
L
N
A
D
N
T
I
D
G
I
L
V
Q
L
P
L
--
P
A
--
G
-
I
D
N
V
K
V
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
V
G
R
L
-
C
Q
--
R
--
A
--
P
--
R
-
L
R
P
C
T
P
R
G
I
V
T
L
L
E
R
Y
N
I
D
T
F
G
L
N
A
V
V
I
G
A
S
N
I
V
G
R
P
M
S
M
E
L
L
L
A
G
C
T
T
T
V
T
H
--
R
F
T
K
--
N
L
R
H
H
V
E
N
A
D
L
L
I
V
A
V
G
K
P
G
F
I
P
G
D
W
I
K
E
G
A
I
V
I
D
V
G
I
N
R
L
E
N
-----
G
------
K
-
V
V
G
D
V
V
F
E
D
A
A
K
R
A
S
Y
I
T
P
V
P
G
G
V
G
P
M
T
V
A
T
L
I
E
N
T
L
Q
A
C
V
E
Y
H
D
P
Q
D
-
31
PsiBlast_CBE
90.39
37%
-118
- C7 -
4CJX
2
?
B:
[22-317]
M
P
E
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
R
-
R
Y
K
G
R
-
R
-
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
-
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
P
--
H
-
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
-
H
I
--
R
--
E
--
R
NP
A
-
I
V
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
N
E
D
A
T
V
T
V
V
H
--
S
A
T
P
LC
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
T
P
V
A
D
-----
P
SKVPGY
R
-
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
S
V
R
A
---
10
PsiBlast_PDB
88.84
40%
-124
- C7 -
4A26
1
?
A:
[8-294]
-------
I
I
D
G
K
A
I
A
A
A
I
R
S
E
L
K
D
K
V
A
A
L
R
E
-
L
Y
G
-
G
-
R
V
P
G
L
A
S
I
I
V
G
Q
R
M
D
S
K
K
Y
V
Q
L
K
H
K
A
A
A
E
V
G
M
A
S
F
N
V
E
-
L
P
E
D
I
S
Q
E
V
L
E
V
N
V
E
K
L
N
N
D
P
N
C
H
G
I
I
V
Q
L
P
L
--
P
K
--
H
-
L
N
E
N
R
A
I
E
K
I
H
P
H
K
D
A
D
A
L
L
P
V
N
V
G
L
L
-
H
Y
KG
R
--
E
--
P
--
P
-
F
T
P
C
T
A
K
G
V
I
V
L
L
K
R
C
G
I
E
M
A
G
K
R
A
V
V
L
G
R
S
N
I
V
G
A
P
V
A
A
L
L
M
K
E
N
A
T
V
T
I
V
H
SG
T
S
T
E
--
D
M
I
D
Y
L
R
T
A
D
I
V
I
A
A
M
G
Q
P
G
Y
V
K
G
E
W
I
K
E
G
A
A
V
V
D
V
G
T
T
P
V
P
D
-----
P
SRKDG
Y
R
-
L
V
G
D
V
C
F
E
E
A
A
A
R
A
A
W
I
S
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
L
E
A
F
K
A
A
L
G
V
S
--
25
PsiBlast_CBE
88.38
40%
-120
- C7 -
4A26
1
?
B:
[8-294]
-------
I
I
D
G
K
A
I
A
A
A
I
R
S
E
L
K
D
K
V
A
A
L
R
E
-
L
Y
G
-
G
-
R
V
P
G
L
A
S
I
I
V
G
Q
R
M
D
S
K
K
Y
V
Q
L
K
H
K
A
A
A
E
V
G
M
A
S
F
N
V
E
-
L
P
E
D
I
S
Q
E
V
L
E
V
N
V
E
K
L
N
N
D
P
N
C
H
G
I
I
V
Q
L
P
L
--
P
K
--
H
-
L
N
E
N
R
A
I
E
K
I
H
P
H
K
D
A
D
A
L
L
P
V
N
V
G
L
L
-
H
Y
KG
R
--
E
--
P
--
P
-
F
T
P
C
T
A
K
G
V
I
V
L
L
K
R
C
G
I
E
M
A
G
K
R
A
V
V
L
G
R
S
N
I
V
G
A
P
V
A
A
L
L
M
K
E
N
A
T
V
T
I
V
H
SG
T
S
T
E
--
D
M
I
D
Y
L
R
T
A
D
I
V
I
A
A
M
G
Q
P
G
Y
V
K
G
E
W
I
K
E
G
A
A
V
V
D
V
G
T
T
P
V
P
D
-----
P
SG
Y
---
R
-
L
V
G
D
V
C
F
E
E
A
A
A
R
A
A
W
I
S
P
V
P
G
G
V
G
P
M
T
I
A
M
L
L
E
N
T
L
E
A
F
K
A
A
L
G
----
17
PsiBlast_PDB
87.83
37%
-114
- C7 -
4CJX
4
?
A:
[22-317]
M
P
E
--
A
V
V
I
D
G
R
A
V
A
K
A
I
Q
K
E
L
T
E
E
V
A
L
L
E
R
-
R
Y
K
G
R
-
R
-
P
G
L
S
T
I
I
C
G
K
R
K
D
S
Q
T
Y
V
R
L
K
R
K
A
A
A
A
C
G
F
-
R
N
F
S
V
E
L
P
A
N
V
T
Q
E
A
L
E
R
E
V
I
R
L
N
E
E
E
A
C
H
S
I
V
V
Q
L
P
L
--
P
P
--
H
-
I
D
K
V
A
A
L
S
K
I
K
P
E
K
D
A
D
C
L
L
P
V
N
V
G
Q
L
-
H
I
--
R
--
E
--
R
NP
A
-
I
V
P
C
T
A
S
A
V
M
E
L
L
R
C
S
G
V
E
I
C
G
K
R
V
V
V
L
G
R
G
D
I
A
G
L
P
V
A
T
L
L
A
N
E
D
A
T
V
T
V
V
H
--
S
A
T
P
L
C
D
I
A
D
I
V
R
A
S
D
I
V
V
S
A
A
G
Q
P
G
L
V
R
G
E
W
I
K
L
G
A
A
V
I
D
V
G
T
T
P
V
A
D
-----
P
SKVPG
Y
R
-
L
V
G
D
V
C
F
D
V
A
R
K
R
A
A
Y
I
T
P
V
P
G
G
V
G
P
V
T
V
S
M
L
L
K
N
T
L
T
M
F
K
R
S
V
R
A
---
4
PsiBlast_PDB
87.36
46%
-109
- C7 -
4A5O
2
FOLD_PSEAE
A:
[7-282]
-------
L
I
D
G
K
A
I
A
A
N
L
R
Q
Q
I
A
Q
R
V
T
E
R
R
Q
-
Q
G
L
-
R
-
V
-
P
G
L
A
V
I
L
V
G
T
D
P
A
S
Q
V
Y
V
A
H
K
R
K
D
C
E
E
V
G
F
-
L
S
Q
A
Y
D
L
P
A
E
T
S
Q
D
D
L
L
A
L
I
D
R
L
N
D
D
P
A
I
D
G
I
L
V
Q
L
P
L
--
P
A
--
H
-
L
D
A
S
L
L
L
E
R
I
H
P
D
K
D
V
D
G
F
H
P
Y
N
I
G
R
L
-
A
Q
--
R
--
M
--
P
--
L
-
L
R
P
C
T
P
K
G
I
M
T
L
L
A
S
T
G
A
D
L
Y
G
M
D
A
V
V
V
G
A
S
N
I
V
G
R
P
M
A
L
E
L
L
L
G
G
C
T
V
T
V
T
H
--
R
F
T
R
--
D
L
A
D
H
V
S
R
A
D
L
V
V
V
A
A
G
K
P
G
L
V
K
G
E
W
I
K
E
G
A
I
V
I
D
V
G
I
N
R
Q
A
D
-----
G
------
R
-
L
V
G
D
V
E
Y
E
V
A
A
Q
R
A
S
W
I
T
P
V
P
G
G
V
G
P
M
T
R
A
C
L
L
E
N
T
L
H
A
A
E
H
L
H
D
----
27
PsiBlast_CBE
86.03
36%
-122
- C7 -
1DIB
1
C1TC_HUMAN
B:
[6-288]
-------
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
V
P
-
G
F
T
-
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
--
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
V
P
D
DKKPN
G
------
R
K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
----
11
PsiBlast_PDB
85.51
36%
-122
- C7 -
1DIA
2
C1TC_HUMAN
A:
[6-288]
-------
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
V
P
-
G
F
T
-
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
--
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
----
13
PsiBlast_PDB
85.20
36%
-121
- C7 -
1DIG
2
C1TC_HUMAN
A:
[6-288]
-------
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
V
P
-
G
F
T
-
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
--
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
----
38
HHSearch
84.85
36%
-112
- C7 -
1A4I
1
C1TC_HUMAN
A:
[2-296]
---
A
P
A
E
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
Q
V
P
G
-
F
-
T
-
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
--
D
S
EN
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
--
D
LN
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
--
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
---------------
K
-
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
----
12
PsiBlast_PDB
84.60
36%
-120
- C7 -
1DIB
2
C1TC_HUMAN
A:
[6-288]
-------
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
V
P
-
G
F
T
-
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
--
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
----
14
PsiBlast_PDB
84.41
36%
-118
- C7 -
1A4I
1
C1TC_HUMAN
A:
[6-288]
-------
I
L
N
G
K
E
I
S
A
Q
I
R
A
R
L
K
N
Q
V
T
Q
L
K
E
-
Q
V
P
-
G
F
T
-
P
R
L
A
I
L
Q
V
G
N
R
D
D
S
N
L
Y
I
N
V
K
L
K
A
A
E
E
I
G
I
-
K
A
T
H
I
K
L
P
R
T
T
T
E
S
E
V
M
K
Y
I
T
S
L
N
E
D
S
T
V
H
G
F
L
V
Q
L
P
L
DS
E
N
--
S
-
I
N
T
E
E
V
I
N
A
I
A
P
E
K
D
V
D
G
L
T
S
I
N
A
G
R
L
-
A
R
--
G
DL
N
--
D
--
C
-
F
I
P
C
T
P
K
G
C
L
E
L
I
K
E
T
G
V
P
I
A
G
R
H
A
V
V
V
G
R
S
K
I
V
G
A
P
M
H
D
L
L
L
W
N
N
A
T
V
T
T
C
H
--
S
K
T
A
--
H
L
D
E
E
V
N
K
G
D
I
L
V
V
A
T
G
Q
P
E
M
V
K
G
E
W
I
K
P
G
A
I
V
I
D
C
G
I
N
Y
----------------K
V
V
G
D
V
A
Y
D
E
A
K
E
R
A
S
F
I
T
P
V
P
G
G
V
G
P
M
T
V
A
M
L
M
Q
S
T
V
E
S
A
K
R
F
L
E
----
30
PsiBlast_CBE
83.01
36%
-115
- C7 -
3NGL
1
FOLD_THEAC
C:
[3-273]
-------
I
L
R
G
E
E
I
A
---
E
K
K
A
E
N
-
L
H
G
I
I
E
-
R
S
G
-
L
-
E
-
P
S
L
K
L
I
Q
I
G
D
N
E
A
A
S
I
Y
A
R
A
K
I
R
R
G
K
K
I
G
I
-
A
V
D
L
E
K
Y
-
D
D
I
S
M
K
D
L
L
K
R
I
D
D
L
A
K
D
P
Q
I
N
G
I
M
I
E
N
P
L
--
P
K
--
G
-
F
D
Y
Y
E
I
V
R
N
I
P
Y
Y
K
D
V
D
A
L
S
P
Y
N
Q
G
L
I
-
A
L
--
N
--
R
--
E
--
F
-
L
V
P
A
T
P
R
A
V
I
D
I
M
D
Y
Y
G
Y
H
--
E
N
T
V
T
I
V
N
R
S
P
V
V
G
R
P
L
S
M
M
L
L
N
R
N
Y
T
V
S
V
C
H
--
S
K
T
K
--
D
I
G
S
M
T
R
S
S
K
I
V
V
V
A
V
G
R
P
G
F
L
N
R
E
M
V
T
P
G
S
V
V
I
D
V
G
I
N
Y
V
N
D
------------
K
-
V
V
G
D
A
N
F
E
D
L
S
E
Y
V
E
A
I
T
P
V
P
G
G
V
G
P
I
T
A
T
N
I
L
E
N
V
V
K
A
A
E
F
Q
K
N
N
---
15
PsiBlast_PDB
82.30
36%
-115
- C7 -
3NGL
1
FOLD_THEAC
A:
[3-273]
-------
I
L
R
G
E
E
I
A
---
E
K
K
A
E
N
-
L
H
G
I
I
E
-
R
S
G
-
L
-
E
-
P
S
L
K
L
I
Q
I
G
D
N
E
A
A
S
I
Y
A
R
A
K
I
R
R
G
K
K
I
G
I
-
A
V
D
L
E
K
Y
-
D
D
I
S
M
K
D
L
L
K
R
I
D
D
L
A
K
D
P
Q
I
N
G
I
M
I
E
N
P
L
--
P
K
--
G
-
F
D
Y
Y
E
I
V
R
N
I
P
Y
Y
K
D
V
D
A
L
S
P
Y
N
Q
G
L
I
-
A
L
--
N
--
R
--
E
--
F
-
L
V
P
A
T
P
R
A
V
I
D
I
M
D
Y
Y
G
Y
H
--
E
N
T
V
T
I
V
N
R
S
P
V
V
G
R
P
L
S
M
M
L
L
N
R
N
Y
T
V
S
V
C
H
--
S
K
T
K
--
D
I
G
S
M
T
R
S
S
K
I
V
V
V
A
V
G
R
P
G
F
L
N
R
E
M
V
T
P
G
S
V
V
I
D
V
G
I
N
Y
V
N
D
------------
K
-
V
V
G
D
A
N
F
E
D
L
S
E
Y
V
E
A
I
T
P
V
P
G
G
V
G
P
I
T
A
T
N
I
L
E
N
V
V
K
A
A
E
F
Q
K
N
N
L
--