@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0532: (2015-12-16 )
MSLKRAKTKAQQIKELLLKHYPNQTTELRHKNPYELLVATILSAQCTDARVNQITPKLFEKYPSVNDLALASLEEVKEIIQSVSYSNNKSKHLISMGAKVVKDFKGVIPSTQKELMSLDGVGQKTANVVLSVCFDANYIAVDTHVFRTTHRLGLSNANTPIKTEEELSDLFKDNLSKLHHALILFGRYTCKAKNPLCDACFLKEFCVSKASFKA
Atome Classification :
(20 SA)
.........10...---.....20....-...---.30----------.........40........50.....---...60........70---........80........90........100.......110.....-..120.......130.......140.......150.-..-----..-.-----.-----.160...----.....170.-.-----...-...180.......190.......200.......210..---------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSL
K
R
A
K
T
K
A
Q
Q
I
K
---
E
L
L
L
K
HYPNQT-TEL---RH-----------K
N
P
Y
E
L
L
V
A
T
I
L
SAQCTDA
R
V
N
QI
T
P
---
K
L
F
E
KYPSV
N
D
L
A
L
A
---
S
L
E
E
V
K
E
I
I
Q
S
VSYSNNKS
K
H
L
I
S
M
G
A
K
V
V
K
D
F
K
G
VIP
S
T
Q
K
E
L
M
S
-LDGVG
Q
K
T
A
N
V
V
L
S
V
C
FDA
N
Y
I
A
V
D
T
H
V
F
R
T
T
H
R-L-GL-----SN-A-----N-----TPI-K
T
E
----
E
E
L
S
D
L
F
-
K
-
D
-----
N
L
S
-
K
L
H
H
A
L
I
L
F
G
R
Y
TCKAKNPLC
D
A
C
F
L
K
E
F
C
VSKASFKA---------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.17
43%
-113
- C1 -
1ORN
5
?
A:
[8-208]
----------
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
A
H
-
C
E
L
---
V
H
-----------
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
---
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
---
P
L
E
E
L
E
Q
D
I
R
S
I
G
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
E
V
P
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
A
I
A
V
D
T
H
V
E
R
V
S
K
R
-
L
-
G
F
-----
C
R
-
W
-----
D
-----
D
S
V
L
E
V
E
----
K
T
L
M
K
I
I
P
K
-
E
-----
E
W
S
-
I
T
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
---------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.63
43%
-116
- C1 -
1ORP
4
?
A:
[8-208]
----------
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
A
H
-
C
E
L
---
V
H
-----------
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
---
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
---
P
L
E
E
L
E
Q
D
I
R
S
I
G
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
E
V
P
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
A
I
A
V
D
T
H
V
E
R
V
S
K
R
-
L
-
G
F
-----
C
R
-
W
-----
D
-----
D
S
V
L
E
V
E
----
K
T
L
M
K
I
I
P
K
-
E
-----
E
W
S
-
I
T
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
---------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.11
42%
-111
- C1 -
1P59
4
?
A:
[8-208]
----------
Q
Q
I
R
Y
C
L
D
E
M
A
K
M
F
P
D
A
H
-
C
E
L
---
V
H
-----------
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
---
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
---
P
L
E
E
L
E
Q
D
I
R
S
I
G
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
E
V
P
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
T
A
F
G
V
P
A
I
A
V
D
T
H
V
E
R
V
S
K
R
-
L
-
G
F
-----
C
R
-
W
-----
D
-----
D
S
V
L
E
V
E
----
K
T
L
M
K
I
I
P
K
-
E
-----
E
W
S
-
I
T
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
---------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
92.59
36%
-104
- C1 -
2ABK
1
END3_ECOLI
A:
[3-209]
------
K
A
K
R
L
E
I
L
---
T
R
L
R
E
N
N
P
H
P
T
-
T
E
L
---
N
F
-----------
S
S
P
F
E
L
L
I
A
V
L
L
S
A
Q
A
T
D
V
S
V
N
K
A
T
A
---
K
L
Y
P
V
A
N
T
P
A
A
M
L
E
L
---
G
V
E
G
V
K
T
Y
I
K
T
I
G
L
Y
N
S
K
A
E
N
I
I
K
T
C
R
I
L
L
E
Q
H
N
G
E
V
P
E
D
R
A
A
L
E
A
-
L
P
G
V
G
R
K
T
A
N
V
V
L
N
T
A
F
G
W
P
T
I
A
V
D
T
H
I
F
R
V
C
N
R
-
T
-
Q
F
-----
A
P
-
G
-----
K
-----
N
V
E
-
Q
V
E
----
E
K
L
L
K
V
V
P
A
-
E
-----
F
K
V
-
D
C
H
H
W
L
I
L
H
G
R
Y
T
C
I
A
R
K
P
R
C
G
S
C
I
I
E
D
L
C
E
Y
K
E
K
V
D
I
---------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
92.52
41%
-95
- C1 -
1ORN
5
?
A:
[4-214]
---
M
L
T
K
Q
Q
I
R
Y
C
L
---
D
E
M
A
K
M
F
P
D
A
H
-
C
E
L
---
V
H
-----------
R
N
P
F
E
L
L
I
A
V
V
L
S
A
Q
C
T
D
A
L
V
N
K
V
T
K
---
R
L
F
E
K
Y
R
T
P
H
D
Y
I
A
V
---
P
L
E
E
L
E
Q
D
I
R
S
I
G
L
Y
R
N
K
A
R
N
I
Q
K
L
C
A
M
L
I
D
K
Y
N
G
E
V
P
R
D
R
D
E
L
M
K
-
L
P
G
V
G
R
K
T
A
N
V
V
V
S
V
A
F
G
V
P
A
I
A
V
D
T
H
V
E
R
V
S
K
R
-
L
-
G
F
-----
C
R
W
D
-----
D
-----
S
V
L
-
E
V
E
----
K
T
L
M
K
I
I
P
K
-
E
-----
E
W
S
-
I
T
H
H
R
M
I
F
F
G
R
Y
H
C
K
A
Q
S
P
Q
C
P
S
C
P
L
L
H
L
C
R
E
G
K
K
R
M
R
---------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.63
38%
-108
- C1 -
2ABK
1
END3_ECOLI
A:
[3-203]
------
K
A
K
R
L
E
I
L
---
T
R
L
R
E
N
N
P
H
P
T
-
T
E
L
---
N
F
-----------
S
S
P
F
E
L
L
I
A
V
L
L
S
A
Q
A
T
D
V
S
V
N
K
A
T
A
---
K
L
---
Y
P
V
A
N
T
P
A
A
M
L
E
L
G
V
E
G
V
K
T
Y
I
K
T
I
G
L
Y
N
S
K
A
E
N
I
I
K
T
C
R
I
L
L
E
Q
H
N
G
E
V
P
E
D
R
A
A
L
E
A
-
L
P
G
V
G
R
K
T
A
N
V
V
L
N
T
A
F
G
W
P
T
I
A
V
D
T
H
I
F
R
V
C
N
R
-
T
-
Q
F
-----
A
P
-
G
-----
K
-----
N
V
E
-
Q
V
E
----
E
K
L
L
K
V
V
-
P
-
A
-----
E
F
K
V
D
C
H
H
W
L
I
L
H
G
R
Y
T
C
I
A
R
K
P
R
C
G
S
C
I
I
E
D
L
C
E
Y
K
E
K
V
D
I
---------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
83.56
24%
-101
- C1 -
1KG2
6
MUTY_ECOLI
A:
[3-214]
---------
A
S
Q
F
S
---
A
Q
V
L
D
W
Y
D
K
Y
G
R
K
T
L
---
P
W
QID--------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
---
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
---
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
-
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
-
C
-
Y
A
-----
V
S
G
W
-----
P
-----
G
K
K
-
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
-
V
-----
G
V
E
-
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
---------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
83.19
25%
-101
- C1 -
3N5N
1
MUTYH_HUMAN
X:
[13-234]
-------
A
E
V
T
A
F
R
---
G
S
L
L
S
W
Y
D
Q
E
K
-
R
D
L
---
P
W
RRRAEDEMDLD
R
R
A
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
---
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
---
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
-
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
-
V
-
R
A
-----
I
G
-
A
-----
D
PSSTL
V
S
Q
-
Q
L
W
----
G
L
A
Q
Q
L
V
D
P
-
A
-----
R
P
G
-
D
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
S
L
C
R
A
R
Q
R
V
E
Q
---------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.95
25%
-95
- C1 -
1KG2
6
MUTY_ECOLI
A:
[28-213]
------------------------------------------------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
---
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
---
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
-
A
V
-----
S
G
-
W
-----
P
-----
G
K
K
-
E
V
E
----
N
K
L
W
S
L
S
-
E
-
Q
V
TPAV
G
V
E
-
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
---------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.71
25%
-96
- C1 -
1KG4
4
MUTY_ECOLI
A:
[28-213]
------------------------------------------------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
---
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
---
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
-
A
V
-----
S
G
-
W
-----
P
-----
G
K
K
-
E
V
E
----
N
K
L
W
S
L
S
-
E
-
Q
V
TPAV
G
V
E
-
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
---------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
81.23
25%
-96
- C1 -
1KG6
8
MUTY_ECOLI
A:
[28-213]
------------------------------------------------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
---
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
---
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
R
R
V
L
A
R
C
Y
-
A
V
-----
S
G
-
W
-----
P
-----
G
K
K
-
E
V
E
----
N
K
L
W
S
L
S
-
E
-
Q
V
TPAV
G
V
E
-
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
---------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
81.12
25%
-91
- C1 -
1WEF
1
MUTY_ECOLI
A:
[28-213]
------------------------------------------------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
---
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
---
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
-
A
V
-----
S
G
-
W
-----
P
-----
G
K
K
-
E
V
E
----
N
K
L
W
S
L
S
-
E
-
Q
V
TPAV
G
V
E
-
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
---------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
81.10
23%
-104
- C1 -
4YPH
4
?
A:
[12-217]
--------
P
A
R
E
F
Q
---
R
D
L
L
D
W
F
A
R
E
R
-
R
D
L
PWR
K
D
-----------
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
---
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
---
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
-
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
-
L
-
F
L
VTDDI
A
K
-
C
-----
S
-----
T
R
K
-
R
F
E
----
Q
I
V
R
E
I
M
-
A
Y
E
-----
N
P
G
-
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
---------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.80
25%
-92
- C1 -
1MUY
4
MUTY_ECOLI
A:
[28-213]
------------------------------------------------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
---
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
---
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
-
A
V
-----
S
G
-
W
-----
P
-----
G
K
K
-
E
V
E
----
N
K
L
W
S
L
S
-
E
-
Q
V
TPAV
G
V
E
-
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
---------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.48
25%
-97
- C1 -
1KG5
6
MUTY_ECOLI
A:
[28-213]
------------------------------------------------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
---
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
---
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
Q
R
V
L
A
R
C
Y
-
A
V
-----
S
G
-
W
-----
P
-----
G
K
K
-
E
V
E
----
N
K
L
W
S
L
S
-
E
-
Q
V
TPAV
G
V
E
-
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
---------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.47
23%
-105
- C1 -
3FSP
4
?
A:
[11-217]
-------
F
P
A
R
E
F
Q
---
R
D
L
L
D
W
F
A
R
E
R
-
R
D
L
PWR
K
D
-----------
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
---
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
---
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
-
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
-
L
-
F
L
VTDDI
A
K
-
P
-----
S
-----
T
R
K
-
R
F
E
----
Q
I
V
R
E
I
M
-
A
Y
E
-----
N
P
G
-
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
---------------------------------------------------------------------------------------------------------------------------------
46
Fugue
80.35
23%
-97
- C1 -
1RRQ
4
?
A:
[12-362]
--------
P
A
R
E
F
Q
---
R
D
L
L
D
W
F
A
R
E
R
-
R
D
L
---
P
W
RKD--------
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
---
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
---
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
-
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
-
L
F
L
V
-----
T
D
-
D
-----
I
-----
A
K
C
-
S
T
R
----
K
R
F
E
Q
I
V
-
R
-
E
IMAYE
N
P
G
-
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
EELPVKMV
K
Q
V
P
L
A
V
A
V
L
A
D
DE
G
R
V
L
I
R
K
R
D
STGLLAN
L
W
E
F
PSCETDGADG
K
E
K
L
E
Q
M
VGL
Q
V
E
L
T
E
PI
V
S
F
E
H
A
F
SHLVWQ
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
EDELKA
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
26
HHSearch
80.33
24%
-94
- C1 -
3FSP
4
?
A:
[11-222]
-------
F
P
A
R
E
F
Q
---
R
D
L
L
D
W
F
A
R
E
R
-
R
D
L
---
P
W
RKD--------
R
D
P
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
---
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
---
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
-
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
-
L
-
F
L
-----
V
T
-
D
DIAK
P
S
-----
T
R
K
-
R
F
E
----
Q
I
V
R
E
I
M
A
Y
-
E
-----
N
P
G
-
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
C
Q
A
F
A
E
G
V
A
---------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.17
25%
-92
- C1 -
1WEG
4
MUTY_ECOLI
A:
[28-213]
------------------------------------------------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
---
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
---
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
-
A
V
-----
S
G
-
W
-----
P
-----
G
K
K
-
E
V
E
----
N
K
L
W
S
L
S
-
E
-
Q
V
TPAV
G
V
E
-
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
---------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.09
25%
-99
- C1 -
1KG3
7
MUTY_ECOLI
A:
[28-213]
------------------------------------------------
K
T
P
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
---
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
---
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
-
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
-
A
V
-----
S
G
-
W
-----
P
-----
G
K
K
-
E
V
E
----
N
K
L
W
S
L
S
-
E
-
Q
V
TPAV
G
V
E
-
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
N
G
C
I
A
A
A
N
N
S
W
---------------------------------------------------------------------------------------------------------------------------------