@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0547: (2015-12-16 )
MDTIKSIPIRTFILLYKSSPKCVVLASITVLFVGILPSLNILVMIKLIDIVVNLLQKHTHFEYSLLLPTLLLWGALLFLTHVFSGILSSLQTIIAEQFSINIITQLANKLTQVKNLNFFENKDHTIKLNTIHNGLHIRPLNYVSNLFFNLQRIIGLISLFGILFSISIYLPFIMIFATVPCILISNHIAKKHSASIDKLQDQKESMQNYLYSGLDNQKNKDNLLFNFMLNFHHKFIETKELYLNNFVKVAQKNLIFTIYADVLITTLSIALFFLMVFIILSKLIGVGAIAGYIQAFSSTQQQLQDLSFYGKWFFAINKYFENYFCILDYKIPKPETQIKLEEKIHSITFENISFSYPNSKLIFENFNLSLHSNKIYALVGKNASGKSTLINLLLGFYTPNSGQIIINNKYPLQDLELNSYHQQMSAIFQDFSLYAGYSIDDNLFMQNNITKEQLKQKREILKSFDENFQNCLNDCNNTLFGAQYNGVDFSLGQKQRIATMRAFLKPSNCIVLDEPSSAIDPIMEKEFLDFIFKKSQSKMALIITHRMNSVKQANEIIVLDQGKLIEQGNFETLMKKQGLFCELFLKQQY
Atome Classification :
(29 SA)
--------------------------------------------------------.........10........20........30...-.....40..--......50--------------.........60........70........80........90........100.......110.......120.......130.......140--.......--150......-------..160--........170.......180.......190.......200.......210....---...220.......230.......240.......250.......260----.........270....----...280.----......290.......300.......310.......320.......330.......------.---.340..--.-....350....-..--.--360.........370.......380.......390.....--..400-.........410.......420.......430...-------....440...--..-..----450......------.460----...--......470.......480.......490.......500.......510.......520..---....--.530...--....540.......550.......560.......570....--.--...580.......-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------MDTIKSIP
I
R
T
F
I
L
L
YKSSP
K
C
V
V
L
A
S
I
T
V
L
F
V
G
-
I
LPS
L
N
I
L
V
--
M
I
K
L
I
D
I
---------------
V
V
N
L
L
Q
KHTHF
E
Y
S
L
L
L
P
T
L
L
L
W
G
A
L
L
F
L
T
H
V
F
S
G
I
L
S
S
L
Q
T
I
I
A
E
Q
F
S
I
N
I
I
T
Q
L
A
N
K
L
T
Q
VKNLNFFENKD
H
T
I
K
L
N
T
IHNG
L
H
I
R
P
L
N
Y
--
V
S
N
L
F
F
N
--
L
-
Q
R
I
I
G
L
I
-------
S
L
F
G
---
I
L
F
S
I
S
I
Y
L
P
F
I
M
I
F
AT
V
P
C
I
L
I
S
N
H
I
A
K
KHSA
S
I
D
K
L
Q
D
Q
K
E
S
M
Q
N
Y
L
Y
SGLDN---QKNK
D
N
L
L
F
N
F
M
L
N
F
H
H
K
F
I
E
T
K
E
L
Y
L
N
N
F
V
K
V
A
QK
N
L
I
F
T
I
Y
A
------
D
V
L
I
T
T
L
S
I
A
L
F
F
L
M
V
----
F
I
I
L
S
K
L
----
I
G
V
G
A
I
A
G
Y
I
Q
A
F
S
S
T
Q
Q
Q
L
Q
D
L
S
F
Y
G
K
W
F
F
A
I
N
K
Y
FE
N
Y
F
C
I
L
D
YK--IPKPET
Q
------
I
---
K
L
E
EKI--H-
S
I
T
F
EN
I
S
FSY-PN--
S
--
K
--
L
I
F
E
NF
N
L
S
L
HS
N
K
I
Y
A
L
VGKNAS
G
K
S
T
L
I
N
L
L
L
G
FY--TPN---S
G
Q
I
I
INNKYPLQDL
E
L
N
S
Y
H
Q
Q
M
S
A
I
F
Q
D
F
S
LYA-------GYSIDD
N
L
F
M--QN-NI----
T
K
E
Q
L
K
Q
K
R
------
E
I
------
L
K
S
--
F
D
E
N
F
Q
N
C
L
N
DCNN
T
L
FGAQYNGVDFSLG
Q
K
Q
R
I
A
T
M
R
A
FLKPS
N
C
I
V
LDEPSS
A
I
D
P
I
M
E
---
K
E
F
L
--
D
F
I
F
K
KS--QS
K
M
A
L
I
I
T
HRMNSVKQA
N
E
I
I
V
LDQG
K
L
IEQG
N
F
-
E
T
L
M
K
--K--QG
L
F
C
E
L
F
L
KQQY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.10
23%
-96
- C2 -
3WMG
6
?
A:
[16-595]
-----------------------------------------------------------------
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
---------------
S
K
S
Q
I
E
G
E
T
-
W
K
Y
S
V
G
F
V
G
I
---
G
V
F
E
F
---
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
-
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
G
A
V
L
F
N
--
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
---
V
L
I
A
L
S
---
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
---
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
-
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
--
F
S
A
I
L
G
F
----
M
G
V
G
------
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
-------
V
P
Q
Y
R
--
R
P
D
P
G
A
E
------
V
---
V
T
Q
P
L
V
LK
Q
-
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
--
R
--
M
NV
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
DI
E
P
Q
---
G
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
-------
G
T
I
R
D
N
I
L
Y
G
--
K
R
-
D
A
----
T
D
E
E
V
I
Q
A
L
------
R
E
------
A
N
A
--
Y
--
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
--
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
--
D
R
M
M
-
A
S
--
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
-
S
E
L
M
A
L
G
P
--
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.00
25%
-109
- C2 -
3QF4
1
Y288_THEMA
B:
[72-590]
---------------------------------------------------------------------------------------------------------------------------------------
R
F
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
-
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
-----
D
N
--
I
N
N
V
L
G
N
S
I
I
-
Q
F
F
S
G
I
V
-------
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
-
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
--------
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
------
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
----
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
--
E
E
K
D
D
P
D
A-----
V
---
E
L
R
E
V
R
--
G
-
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
--
K
--
K
--
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
--
D
V
D
---
R
G
Q
I
L
V
D
G
-
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
--------
T
T
V
K
E
N
L
K
Y
--
G
N
P
G
A
----
T
D
E
E
I
K
E
A
A
------
K
L
T
HS
D
H
F
I
K
H
--
L
P
E
G
Y
E
T
V
L
T
D
----------
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
---
K
S
I
Q
--
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
-
D
E
L
I
Q
--
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
79.82
23%
-94
- C2 -
3WMF
1
?
A:
[16-595]
-----------------------------------------------------------------
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
---------------
S
K
S
Q
I
E
G
E
T
-
W
K
Y
S
V
G
F
V
G
I
---
G
V
F
E
F
---
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
-
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
G
A
V
L
F
N
--
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
---
V
L
I
A
L
S
---
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
---
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
-
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
--
F
S
A
I
L
G
F
----
M
G
V
G
------
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
-------
V
P
Q
Y
R
--
R
P
D
P
G
A
E
------
V
---
V
T
Q
P
L
V
LK
Q
-
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
--
R
--
M
NV
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
DI
E
P
Q
---
G
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
-------
G
T
I
R
D
N
I
L
Y
G
--
K
R
-
D
A
----
T
D
E
E
V
I
Q
A
L
------
R
E
------
A
N
A
--
Y
--
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
--
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
--
D
R
M
M
-
A
S
--
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
-
S
E
L
M
A
LG
P
--
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.40
25%
-107
- C2 -
4Q4A
1
Y288_THEMA
B:
[72-590]
---------------------------------------------------------------------------------------------------------------------------------------
R
F
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
-
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
-----
D
N
--
I
N
N
V
L
G
N
S
I
I
-
Q
F
F
S
G
I
V
-------
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
-
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
--------
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
------
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
----
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
--
E
E
K
D
D
P
D
A-----
V
---
E
L
R
E
V
R
--
G
-
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
--
K
--
K
--
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
--
D
V
D
---
R
G
Q
I
L
V
D
G
-
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
--------
T
T
V
K
E
N
L
K
Y
--
G
N
P
G
A
----
T
D
E
E
I
K
E
A
A
------
K
L
T
HS
D
H
F
I
K
H
--
L
P
E
G
Y
E
T
V
L
T
D
----------
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
---
K
S
I
Q
--
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
-
D
E
L
I
Q
--
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.89
23%
-99
- C2 -
3WME
1
?
A:
[16-595]
-----------------------------------------------------------------
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
V
F
T
K
---------------
S
K
S
Q
I
E
G
E
T
-
W
K
Y
S
V
G
F
V
G
I
---
G
V
F
E
F
---
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
-
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
L
G
A
V
L
F
N
--
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
---
V
L
I
A
L
S
---
P
L
V
V
L
A
G
A
A
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
---
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
-
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
R
G
S
L
N
L
G
N
L
L
T
A
F
--
F
S
A
I
L
G
F
----
M
G
V
G
------
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
-------
V
P
Q
Y
R
--
R
P
D
P
G
A
E
------
V
---
V
T
Q
P
L
V
LK
Q
-
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
--
R
--
M
NV
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
P
Q
---
G
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
-------
G
T
I
R
D
N
I
L
Y
G
--
K
R
-
D
A
----
T
D
E
E
V
I
Q
A
L
------
R
E
------
A
N
A
--
Y
--
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
--
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
--
D
R
M
M
-
A
S
--
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
-
S
E
L
M
A
LG
P
--
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.53
25%
-101
- C2 -
4Q4H
-
Y288_THEMA
B:
[72-590]
---------------------------------------------------------------------------------------------------------------------------------------
R
F
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
-
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
-----
D
N
--
I
N
N
V
L
G
N
S
I
I
-
Q
F
F
S
G
I
V
-------
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
-
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
--------
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
------
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
----
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
--
E
E
K
D
D
P
D
A-----
V
---
E
L
R
E
V
R
--
G
-
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
--
K
--
K
--
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
--
D
V
D
---
R
G
Q
I
L
V
D
G
-
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
--------
T
T
V
K
E
N
L
K
Y
--
G
N
P
G
A
----
T
D
E
E
I
K
E
A
A
------
K
L
T
H
S
D
H
F
I
K
H
--
L
P
E
G
Y
E
T
V
L
T
D
----------
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
---
K
S
I
Q
--
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
-
D
E
L
I
Q
--
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.96
25%
-102
- C2 -
4Q4J
-
Y288_THEMA
B:
[72-590]
---------------------------------------------------------------------------------------------------------------------------------------
R
F
D
L
L
P
R
Y
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
-
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
-----
D
N
--
I
N
N
V
L
G
N
S
I
I
-
Q
F
F
S
G
I
V
-------
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
-
S
I
V
P
L
T
V
L
I
T
Q
I
V
S
S
--------
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
V
G
T
K
A
Q
I
F
S
G
V
L
------
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
K
D
I
----
I
T
V
G
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
L
E
--
E
E
K
D
D
P
D
A-----
V
---
E
L
R
E
V
R
--
G
-
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
--
K
--
K
--
P
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
--
D
V
D
---
R
G
Q
I
L
V
D
G
-
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
--------
T
T
V
K
E
N
L
K
Y
--
G
N
P
G
A
----
T
D
E
E
I
K
E
A
A
------
K
L
T
H
S
D
H
F
I
K
H
--
L
P
E
G
Y
E
T
V
L
T
D
----------
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
---
K
S
I
Q
--
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
-
D
E
L
I
Q
--
K
--
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
74.86
22%
-95
- C2 -
3B60
2
MSBA_SALTY
A:
[28-580]
-------------------------------------------------------------------------------
I
V
A
G
I
A
L
I
L
N
A
-
A
S
D
T
F
M
L
S
L
--
L
K
P
L
L
D
D
---------------
G
F
G
K
---
T
D
-
R
--
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
-
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
--
S
G
A
L
I
T
V
--
V
-
R
E
G
A
S
I
I
-------
G
L
F
I
---
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
---
H
K
E
V
L
--
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
------
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
----
F
P
S
V
M
D
S
----
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
--
Q
E
K
D
E
G
K
------
R
---
V
I
D
R
A
T
--
G
-
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
--
R
E-
V
--
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
--
D
I
D
---
E
G
H
I
L
M
D
G
H
-
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
-------
D
-
T
V
A
N
N
I
A
Y
--
A
R
-
T
E
EY--
S
R
E
Q
I
E
E
A
A
------
R
M
------
A
Y
---
A
-
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
--
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
---
R
A
I
Q
--
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
-
S
E
L
L
A
--
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
73.55
19%
-101
- C2 -
3WMG
6
?
A:
[16-596]
-----------------------------------------------------------------
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
-
A
T
L
P
A
F
A
I
V
--
F
G
R
M
F
Q
V
---------------
F
T
K
S
K
S
Q
I
E
----
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
-
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
-
S
--
F
S
K
L
G
A
V
--
L
-
F
N
L
A
Q
C
V
-------
V
G
I
I
---
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
---
I
R
T
T
K
--
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
------
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
----
Q
L
I
A
R
G
S
----
L
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
--
P
Q
Y
R
R
P
D
PG
A
E
V
V
T
---
Q
P
L
V
L
K
--
Q
-
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
--
R
MN
V
--
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
--
D
I
E
PQG
G
G
L
L
L
F
D
G
T
-
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
-------
G
-
T
I
R
D
N
I
L
Y
--
G
K
-
R
D
A---
T
D
E
E
V
I
Q
A
L
------
R
E
------
A
N
---
A
-
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
--
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
---
A
L
V
Q
--
E
A
L
D
R
M
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
-
S
E
L
M
A
--
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
72.76
22%
-100
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[11-572]
--------------------------------------------------------------------
L
G
L
A
Y
P
E
R
R
R
L
A
A
A
V
G
F
L
T
M
S
S
-
V
I
S
M
S
A
P
F
F
--
L
G
K
I
I
D
V
---------------
I
Y
T
N
P
T
V
D
Y
S
D
N
---
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
-
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
--
T
E
N
L
S
D
G
--
L
-
R
A
G
A
Q
A
S
-------
V
G
I
S
---
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
---
V
R
T
V
R
--
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
------
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
----
L
L
M
G
S
A
H
----
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
--
P
K
L
P
F
N
E
------
G
V
I
L
N
E
K
S
F
Q
--
G
-
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
--
R
PE
V
--
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
--
D
P
A
---
S
G
T
I
S
L
D
G
H
-
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
-------
C
-
S
I
A
E
N
I
A
Y
--
G
A
-
D
D
PSSV
T
A
E
E
I
Q
R
V
A
------
E
V
------
A
N
---
A
-
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
--
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
---
Y
L
V
Q
--
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-
E
E
L
L
S
--
K
P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
70.55
20%
-98
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
-------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
-
A
S
D
T
F
M
L
S
L
--
L
K
P
L
L
D
---------------------
D
G
F
G
K
T
D
R
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
-
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
--
S
G
A
L
I
T
V
--
V
-
R
E
G
A
S
I
I
-------
G
L
F
I
---
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
-----
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
------
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
----
F
P
S
V
M
D
S
----
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
--
Q
E
K
D
E
G
K
------
R
---
V
I
D
R
A
T
--
G
-
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
--
R
E-
V
--
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
--
D
I
D
---
E
G
H
I
L
M
D
G
-
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
-------
D
-
T
V
A
N
N
I
A
Y
AR
T
E
-
E
Y
----
S
R
E
Q
I
E
E
A
A
R
M
A
YA
M
D
F
------
I
N
K
--
M
D
N
G
L
D
T
I
I
G
E
----------
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
---
R
A
I
Q
--
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
-
S
E
L
L
A
--
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Fugue
70.45
21%
-111
- C2 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
R
Y
T
T
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
-
L
Q
G
K
V
S
Q
A
F
--
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
---------
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
--
G
D
K
I
G
M
A
--
F
-
Q
Y
L
S
Q
F
I
-------
T
G
F
I
---
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
---------
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
------
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
----
Y
I
G
V
G
W
V
H
D
GS
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
PV
I
D
S
S
S
K
A
------
G
---
R
K
D
M
K
I
--
K
G
D
I
T
V
E
N
V
H
F
T
Y
-
P
S
RP
D
--
V
--
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
--
D
V
L
---
K
G
K
I
T
I
D
G
-
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
--------
N
C
T
I
E
E
N
I
S
L
G
-
K
E
-
G
I
----
T
R
E
E
M
V
A
A
C
------
K
M
------
A
N
A
----
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
--
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
---
G
I
V
Q
--
Q
A
L
D
K
A
A
--
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
-
R
A
L
M
A
--
Q
--
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
26
PsiBlast_CBE
66.36
34%
-83
- C2 -
2FGJ
2
HLYBP_ECOLX
C:
[8-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
65.09
34%
-83
- C2 -
2FGJ
2
HLYBP_ECOLX
B:
[8-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.20
34%
-95
- C2 -
1MT0
1
A:
[2-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
64.11
34%
-87
- C2 -
2FGJ
2
D:
[8-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.79
34%
-83
- C2 -
3B5J
1
A:
[2-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
63.60
34%
-86
- C2 -
1XEF
3
HLYBP_ECOLX
C:
[2-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
63.55
34%
-86
- C2 -
2PMK
1
A:
[2-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
D
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
62.92
34%
-84
- C2 -
1XEF
3
HLYBP_ECOLX
B:
[2-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.64
34%
-81
- C2 -
1XEF
3
HLYBP_ECOLX
A:
[2-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
62.05
34%
-89
- C2 -
2FGJ
2
HLYBP_ECOLX
A:
[8-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
-
K
E
L
L
S
--
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
61.86
34%
-84
- C2 -
4AYX
2
ABCBA_HUMAN
A:
[341-574]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
--
R
--
P
EV
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
--
D
P
A
---
S
G
T
I
S
L
D
G
-
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
CS
I
A
E
N
I
A
Y
G
A
D
D
------
P
S
-
S
V
----
T
A
E
E
I
Q
R
V
A
------
E
V
------
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
----
T
V
V
G
E
K
--
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
--
A
E
---
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-
E
E
L
L
S
--
K
P-
N
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
61.47
34%
-82
- C2 -
2FGK
2
D:
[8-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
60.91
34%
-82
- C2 -
2FGK
2
HLYBP_ECOLX
B:
[8-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
59.72
34%
-84
- C2 -
2FGK
2
HLYBP_ECOLX
C:
[8-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
58.69
34%
-83
- C2 -
4AYT
2
ABCBA_HUMAN
A:
[341-567]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
--
R
--
P
EV
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
--
D
P
A
---
S
G
T
I
S
L
D
G
-
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
CS
I
A
E
N
I
A
Y
G
A
D
D
------
P
S
-
S
V
----
T
A
E
E
I
Q
R
V
A
------
E
V
------
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
----
T
V
V
G
E
K
--
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
--
A
E
---
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
57.89
34%
-85
- C2 -
2FGK
2
HLYBP_ECOLX
A:
[8-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
R
N
I
R
F
R
Y
K
P
D
--
S
--
P
--
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
--
I
P
E
---
N
G
Q
V
L
I
D
G
-
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
--------
N
R
S
I
I
D
N
I
S
L
--
A
N
P
G
M
----
S
V
E
K
V
I
Y
A
A
------
K
L
------
A
G
A
--
H
D
--
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
--
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
---
H
V
I
M
--
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
--
P
--
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
56.18
33%
-91
- C2 -
4AYW
1
ABCBA_HUMAN
A:
[372-598]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
--
R
--
P
EV
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
--
D
P
A
---
S
G
T
I
S
L
D
G
-
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
CS
I
A
E
N
I
A
Y
G
A
D
D
------
P
S
-
S
V
----
T
A
E
E
I
Q
R
V
A
------
E
V
------
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
----
T
V
V
G
E
K
--
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
--
A
E
---
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
-
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------