@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0575: (2015-12-16 )
MSKKIVVDPITRIEGHLRIEVIVDDDNVITDAFSSSTLFRGLETIIKGRDPRDAGFIAQRICGVCTYSHYKAGVTAVENALGITPPLNAQLVRSLMNMALLFHDHVVHFYTLHGLDWCDILSTLKADPIQAAKLSFKYSPYPINTGAGELKAVQKRLNDFAKSGSLGPFSNGYYGHKTYRLNPEQNLIVLSHYLKLLEIQREAAKMTAIFGAKQPHPQSLTVGGVTSVMDILDPTRLAEWKSKFEVVANFINHAYYPDLVMAGEMFANEPSVIKGCGLRNFIAYEEVLLGKDKYLLSSGVVLDGDISKLHPIDESLIKEEVTHSWYQYEDTKEVQLHPYDGQTNPHYTGLKDGESVGIENKIIPAKVLDTKDKYSWIKSPRYDSKPMEVGPLSSVVVGLAAKNPYVTEVATKFLKDTKLPLEALFSTLGRTAARCIEAKTIADNGLLAFDALVENLKSDQSTCAPYHIDKNQEYKGRYIGQVPRGMLSHWVRIKNGVVENYQAVVPSTWNAGPRDSKNQRGAYEMSLIGTKIADLTQPLEIIRTIHSFDPCIACSVHVMDFKGQSLNEFKVEPNFAKF
Atome Classification :
(41 SA)
--.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170..--.....180.......190.......200.......210.......220...--------....230--------.-.--------......240.......250.......260.......270.......-----280---....-------....--.---290---.----..-----....-----.300.......310--.---.---.---..---...320.......330........340...------....350.......360.......370.......380.......390.......400-.........410.----------------......420...-....430.......440.......450....-...460....--..----..470--....----.....480--..--.......490.......500.......510.......520.......530........540.......550.......560.......570......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MSK
K
I
V
VDPITRIE
G
H
L
R
I
E
V
I
VDDD
N
V
I
T
D
AFS
S
S
T
L
F
R
G
L
E
T
I
IKGRDPR
D
A
G
F
I
A
Q
R
I
C
G
V
C
T
Y
S
H
YK
A
G
V
T
A
V
E
N
ALGITPPL
N
A
Q
L
V
R
S
L
M
N
M
A
L
L
F
H
DH
V
V
H
F
Y
T
LHGL
D
W
C
D
I
L
S
T
LKADPI
Q
A
A
K
L
S
F
KYSPYPINTGA
G
E
L
K
A
V
Q
K
R
L
N
D
F
A
KSGSLGPFSNGYY--GH
K
T
Y
R
LNPEQ
N
L
I
V
L
S
H
Y
L
K
L
L
E
I
Q
R
E
A
A
K
M
T
A
IFGAKQPHPQSLTVG
G
V
--------
T
S
V
M
D
I---------L-
D
--------
P
T
R
L
A
E
W
K
S
K
F
E
V
V
A
N
F
I
N
HAYY
P
D
L
V
M
A
G
E
MFANEP
S
V
I
K
GCGLR-----
N
-----
F
I
A
Y
-------
E
E
V
L
--L---GK----D----
K
Y
-----
L
LSS-----
G
V
V
LDGDISKLHP---I---
D
---
E
---
S
L
---
I
K
E
E
V
T
H
S
WYQYED-T
K
E
V
Q
L
HPYDGQTNP------HYTGLKDGESVGIENKII
P
A
KVLDTK
D
K
Y
S
WIKSPRYDSKPMEVG
P
L
S
S
V
V
V
G
LA---AKN
P
Y
V
T
E
V
A
T
K
F
----------------
L
KDTKL
P
L
E
A
L
F
-
S
T
L
G
R
T
A
A
R
C
I
E
A
K
TIADN
G
L
L
A
F
D
A
L
V
E
N
L
-KSDQS-TCA
P
--
Y
H----IDK----NQEY----KGRYIG----QV--
P
R
G
M
L
S
H
W
V
R
I
KNG
V
V
E
N
Y
Q
A
VVPSTWNAGPRDSKNQRG
A
Y
E
M
S
L
I
G
T
-
K
I
A
D
L
T
Q
P
L
E
I
I
R
T
I
H
SFDP
C
I
A
C
S
V
H
V
M
DFKGQSL
N
E
F
KVEPNFAKF
21
PsiBlast_CBE
94.27
45%
-73
- C5 -
3MYR
7
?
H:
[3-561]
----
E
R
I
V
V
D
P
I
T
R
I
E
G
H
L
R
I
E
A
Q
M
D
G
-
A
T
I
A
Q
A
Y
S
S
G
T
M
V
R
G
I
E
T
I
L
K
G
R
D
P
R
D
A
W
A
F
V
Q
R
I
C
G
V
C
T
L
V
H
G
I
A
S
V
R
A
V
E
D
A
L
R
I
E
L
P
L
N
A
Q
L
I
R
N
L
M
I
G
A
Q
Y
I
H
D
H
V
M
H
F
Y
H
L
H
A
L
D
W
V
D
V
V
S
A
L
S
A
D
P
R
A
T
S
E
L
A
Q
S
I
S
A
W
P
-
K
S
S
P
G
Y
F
A
D
T
Q
K
R
I
K
T
F
V
E
S
G
Q
L
G
I
F
A
N
G
Y
W
--
G
H
P
A
Y
R
L
P
P
E
A
N
L
M
A
V
A
H
Y
L
E
A
L
A
W
Q
R
D
T
A
K
F
H
A
I
F
G
G
K
N
P
H
P
-
N
F
V
V
G
G
V
--------
P
S
P
I
D
L
DSDSA----
L
-
N
--------
A
K
R
L
A
E
V
R
N
L
I
Q
S
M
R
T
F
V
D
Q
V
Y
V
P
D
T
L
A
I
A
G
F
Y
K
D
W
G
E
--
R
G
E
G
L
G
-----
N
-----
F
L
C
Y
-------
G
D
L
P
--
T
---
G
A
----
S
LDPA
T
F
-----
L
F
P
R
-----
G
A
I
L
D
R
D
L
S
T
I
H
E
---
V
---
D
LEA
T
---
G
E
---
I
Q
E
F
V
N
H
S
W
Y
E
Y
S
V
-
G
N
D
R
G
L
H
P
Y
E
G
Q
T
N
L
------
E
Y
D
-----
R
R
G
G
V
A
P
---
P
Y
K
Q
L
D
V
S
D
G
Y
S
W
L
K
A
P
R
W
K
G
R
S
V
E
V
G
P
L
A
R
V
L
M
L
Y
A
---
T
G
H
D
Q
A
R
E
L
V
D
S
T
----------------
L
S
R
L
D
L
P
V
D
A
L
Y
-
S
T
L
G
R
T
A
A
R
A
L
E
S
K
I
L
V
D
A
M
Q
G
W
Y
D
G
L
I
A
N
V
-
K
S
G
D
T
-
K
T
F
N
--
E
T
----
L
W
E
----
P
S
S
W
----
P
S
R
A
Q
G
VGIM
E
A
--
P
R
G
A
L
G
H
W
I
V
I
E
D
G
R
I
A
N
Y
Q
A
V
V
P
S
T
W
N
A
G
P
R
D
G
R
G
Q
A
G
A
Y
E
A
A
L
Q
D
N
H
Q
L
V
D
V
K
Q
P
I
E
I
L
R
T
I
H
S
F
D
P
C
I
A
C
A
V
H
---------------------
22
PsiBlast_CBE
93.89
45%
-75
- C5 -
3MYR
3
?
F:
[1-561]
--
M
S
E
R
I
V
V
D
P
I
T
R
I
E
G
H
L
R
I
E
A
Q
M
D
G
-
A
T
I
A
Q
A
Y
S
S
G
T
M
V
R
G
I
E
T
I
L
K
G
R
D
P
R
D
A
W
A
F
V
Q
R
I
C
G
V
C
T
L
V
H
G
I
A
S
V
R
A
V
E
D
A
L
R
I
E
L
P
L
N
A
Q
L
I
R
N
L
M
I
G
A
Q
Y
I
H
D
H
V
M
H
F
Y
H
L
H
A
L
D
W
V
D
V
V
S
A
L
S
A
D
P
R
A
T
S
E
L
A
Q
S
I
S
A
W
P
-
K
S
S
P
G
Y
F
A
D
T
Q
K
R
I
K
T
F
V
E
S
G
Q
L
G
I
F
A
N
G
Y
W
--
G
H
P
A
Y
R
L
P
P
E
A
N
L
M
A
V
A
H
Y
L
E
A
L
A
W
Q
R
D
T
A
K
F
H
A
I
F
G
G
K
N
P
H
P
-
N
F
V
V
G
G
V
--------
P
S
P
I
D
L
DSDSA----
L
-
N
--------
A
K
R
L
A
E
V
R
N
L
I
Q
S
M
R
T
F
V
D
Q
V
Y
V
P
D
T
L
A
I
A
G
F
Y
K
D
W
G
E
--
R
G
E
G
L
G
-----
N
-----
F
L
C
Y
-------
G
D
L
P
--
T
---
G
A
----
S
LDPA
T
F
-----
L
F
P
R
-----
G
A
I
L
D
R
D
L
S
T
I
H
E
---
V
---
D
LEA
T
---
G
E
---
I
Q
E
F
V
N
H
S
W
Y
E
Y
S
V
-
G
N
D
R
G
L
H
P
Y
E
G
Q
T
N
L
------
E
Y
D
-----
R
R
G
G
V
A
P
---
P
Y
K
Q
L
D
V
S
D
G
Y
S
W
L
K
A
P
R
W
K
G
R
S
V
E
V
G
P
L
A
R
V
L
M
L
Y
A
---
T
G
H
D
Q
A
R
E
L
V
D
S
T
----------------
L
S
R
L
D
L
P
V
D
A
L
Y
-
S
T
L
G
R
T
A
A
R
A
L
E
S
K
I
L
V
D
A
M
Q
G
W
Y
D
G
L
I
A
N
V
-
K
S
G
D
T
-
K
T
F
N
--
E
T
----
L
W
E
----
P
S
S
W
----
P
S
R
A
Q
G
VGIM
E
A
--
P
R
G
A
L
G
H
W
I
V
I
E
D
G
R
I
A
N
Y
Q
A
V
V
P
S
T
W
N
A
G
P
R
D
G
R
G
Q
A
G
A
Y
E
A
A
L
Q
D
N
H
Q
L
V
D
V
K
Q
P
I
E
I
L
R
T
I
H
S
F
D
P
C
I
A
C
A
V
H
---------------------
23
PsiBlast_CBE
93.63
45%
-77
- C5 -
3MYR
4
?
D:
[1-561]
--
M
S
E
R
I
V
V
D
P
I
T
R
I
E
G
H
L
R
I
E
A
Q
M
D
G
-
A
T
I
A
Q
A
Y
S
S
G
T
M
V
R
G
I
E
T
I
L
K
G
R
D
P
R
D
A
W
A
F
V
Q
R
I
C
G
V
C
T
L
V
H
G
I
A
S
V
R
A
V
E
D
A
L
R
I
E
L
P
L
N
A
Q
L
I
R
N
L
M
I
G
A
Q
Y
I
H
D
H
V
M
H
F
Y
H
L
H
A
L
D
W
V
D
V
V
S
A
L
S
A
D
P
R
A
T
S
E
L
A
Q
S
I
S
A
W
P
-
K
S
S
P
G
Y
F
A
D
T
Q
K
R
I
K
T
F
V
E
S
G
Q
L
G
I
F
A
N
G
Y
W
--
G
H
P
A
Y
R
L
P
P
E
A
N
L
M
A
V
A
H
Y
L
E
A
L
A
W
Q
R
D
T
A
K
F
H
A
I
F
G
G
K
N
P
H
P
-
N
F
V
V
G
G
V
--------
P
S
P
I
D
L
DSDSA----
L
-
N
--------
A
K
R
L
A
E
V
R
N
L
I
Q
S
M
R
T
F
V
D
Q
V
Y
V
P
D
T
L
A
I
A
G
F
Y
K
D
W
G
E
--
R
G
E
G
L
G
-----
N
-----
F
L
C
Y
-------
G
D
L
P
--
T
---
G
A
----
S
LDPA
T
F
-----
L
F
P
R
-----
G
A
I
L
D
R
D
L
S
T
I
H
E
---
V
---
D
LEA
T
---
G
E
---
I
Q
E
F
V
N
H
S
W
Y
E
Y
S
V
-
G
N
D
R
G
L
H
P
Y
E
G
Q
T
N
L
------
E
Y
D
-----
R
R
G
G
V
A
P
---
P
Y
K
Q
L
D
V
S
D
G
Y
S
W
L
K
A
P
R
W
K
G
R
S
V
E
V
G
P
L
A
R
V
L
M
L
Y
A
---
T
G
H
D
Q
A
R
E
L
V
D
S
T
----------------
L
S
R
L
D
L
P
V
D
A
L
Y
-
S
T
L
G
R
T
A
A
R
A
L
E
S
K
I
L
V
D
A
M
Q
G
W
Y
D
G
L
I
A
N
V
-
K
S
G
D
T
-
K
T
F
N
--
E
T
----
L
W
E
----
P
S
S
W
----
P
S
R
A
Q
G
VGIM
E
A
--
P
R
G
A
L
G
H
W
I
V
I
E
D
G
R
I
A
N
Y
Q
A
V
V
P
S
T
W
N
A
G
P
R
D
G
R
G
Q
A
G
A
Y
E
A
A
L
Q
D
N
H
Q
L
V
D
V
K
Q
P
I
E
I
L
R
T
I
H
S
F
D
P
C
I
A
C
A
V
H
---------------------
1
PsiBlast_PDB
93.58
45%
-75
- C5 -
3MYR
4
?
B:
[3-561]
----
E
R
I
V
V
D
P
I
T
R
I
E
G
H
L
R
I
E
A
Q
M
D
G
-
A
T
I
A
Q
A
Y
S
S
G
T
M
V
R
G
I
E
T
I
L
K
G
R
D
P
R
D
A
W
A
F
V
Q
R
I
C
G
V
C
T
L
V
H
G
I
A
S
V
R
A
V
E
D
A
L
R
I
E
L
P
L
N
A
Q
L
I
R
N
L
M
I
G
A
Q
Y
I
H
D
H
V
M
H
F
Y
H
L
H
A
L
D
W
V
D
V
V
S
A
L
S
A
D
P
R
A
T
S
E
L
A
Q
S
I
S
A
W
P
-
K
S
S
P
G
Y
F
A
D
T
Q
K
R
I
K
T
F
V
E
S
G
Q
L
G
I
F
A
N
G
Y
W
--
G
H
P
A
Y
R
L
P
P
E
A
N
L
M
A
V
A
H
Y
L
E
A
L
A
W
Q
R
D
T
A
K
F
H
A
I
F
G
G
K
N
P
H
P
-
N
F
V
V
G
G
V
--------
P
S
P
I
D
L
DSDSA----
L
-
N
--------
A
K
R
L
A
E
V
R
N
L
I
Q
S
M
R
T
F
V
D
Q
V
Y
V
P
D
T
L
A
I
A
G
F
Y
K
D
W
G
E
--
R
G
E
G
L
G
-----
N
-----
F
L
C
Y
-------
G
D
L
P
--
T
---
G
A
----
S
LDPA
T
F
-----
L
F
P
R
-----
G
A
I
L
D
R
D
L
S
T
I
H
E
---
V
---
D
LEA
T
---
G
E
---
I
Q
E
F
V
N
H
S
W
Y
E
Y
S
V
-
G
N
D
R
G
L
H
P
Y
E
G
Q
T
N
L
------
E
Y
D
-----
R
R
G
G
V
A
P
---
P
Y
K
Q
L
D
V
S
D
G
Y
S
W
L
K
A
P
R
W
K
G
R
S
V
E
V
G
P
L
A
R
V
L
M
L
Y
A
---
T
G
H
D
Q
A
R
E
L
V
D
S
T
----------------
L
S
R
L
D
L
P
V
D
A
L
Y
-
S
T
L
G
R
T
A
A
R
A
L
E
S
K
I
L
V
D
A
M
Q
G
W
Y
D
G
L
I
A
N
V
-
K
S
G
D
T
-
K
T
F
N
--
E
T
----
L
W
E
----
P
S
S
W
----
P
S
R
A
Q
G
V
G
I
M
E
A
--
P
R
G
A
L
G
H
W
I
V
I
E
D
G
R
I
A
N
Y
Q
A
V
V
P
S
T
W
N
A
G
P
R
D
G
R
G
Q
A
G
A
Y
E
A
A
L
Q
D
N
H
Q
L
V
D
V
K
Q
P
I
E
I
L
R
T
I
H
S
F
D
P
C
I
A
C
A
V
H
---------------------
113
HHSearch
92.75
48%
-70
- C5 -
3MYR
4
?
B:
[3-561]
----
E
R
I
V
V
D
P
I
T
R
I
E
G
H
L
R
I
E
A
Q
M
D
-
G
A
T
I
A
Q
A
Y
S
S
G
T
M
V
R
G
I
E
T
I
L
K
G
R
D
P
R
D
A
W
A
F
V
Q
R
I
C
G
V
C
T
L
V
H
G
I
A
S
V
R
A
V
E
D
A
L
R
I
E
L
P
L
N
A
Q
L
I
R
N
L
M
I
G
A
Q
Y
I
H
D
H
V
M
H
F
Y
H
L
H
A
L
D
W
V
D
V
V
S
A
L
S
A
D
P
R
A
T
S
E
L
A
Q
S
I
-
S
A
W
P
K
S
S
P
G
Y
F
A
D
T
Q
K
R
I
K
T
F
V
E
S
G
Q
L
G
I
F
A
N
G
Y
W
--
G
H
P
A
Y
R
L
P
P
E
A
N
L
M
A
V
A
H
Y
L
E
A
L
A
W
Q
R
D
T
A
K
F
H
A
I
F
G
G
K
N
P
H
P
N
-
F
V
V
G
G
V
--------
P
S
P
------------
I
-
D
LDSDSALN
A
K
R
L
A
E
V
R
N
L
I
Q
S
M
R
T
F
V
D
Q
V
Y
V
P
D
T
L
A
I
A
G
F
Y
K
D
W
G
--
E
R
G
E
G
L
G
-----
N
-----
F
L
C
Y
-------
G
D
L
P
--
T
---
G
A
SLDP
A
----
T
F
-----
L
F
P
R
-----
G
A
I
L
D
R
D
L
S
T
I
H
E
---
V
---
D
---
L
EAT
G
E
---
I
Q
E
F
V
N
H
S
W
Y
E
Y
S
V
-
G
N
D
R
G
L
H
P
Y
E
G
Q
T
N
L
------
E
Y
D
R
R
G
G
--------
V
A
P
P
Y
K
Q
L
D
V
S
D
G
Y
S
W
L
K
A
P
R
W
K
G
R
S
V
E
V
G
P
L
A
R
V
L
M
L
Y
A
---
T
G
H
D
Q
A
R
E
L
V
D
S
T
----------------
L
S
R
L
D
L
P
V
D
A
L
Y
-
S
T
L
G
R
T
A
A
R
A
L
E
S
K
I
L
V
D
A
M
Q
G
W
Y
D
G
L
I
A
N
V
-
K
S
G
D
T
K
T
F
N
E
TL
W
E
P---
S
S
W
----
P
S
R
A
----
Q
G
V
G
I
M
----
E
A
--
P
R
G
A
L
G
H
W
I
V
I
E
D
G
R
I
A
N
Y
Q
A
V
V
P
S
T
W
N
A
G
P
R
D
G
R
G
Q
A
G
A
Y
E
A
A
L
Q
D
N
H
Q
L
V
D
V
K
Q
P
I
E
I
L
R
T
I
H
S
F
D
P
C
I
A
C
A
V
H
---------------------
30
PsiBlast_CBE
91.75
41%
-68
- C5 -
4GD3
6
MBHL_ECOLI
M:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
R
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
31
PsiBlast_CBE
91.49
41%
-67
- C5 -
4GD3
6
MBHL_ECOLI
L:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
R
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
39
PsiBlast_CBE
91.45
41%
-68
- C5 -
3UQY
10
MBHL_ECOLI
L:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
R
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
36
PsiBlast_CBE
91.41
41%
-68
- C5 -
3USC
7
MBHL_ECOLI
M:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
R
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
37
PsiBlast_CBE
91.36
41%
-69
- C5 -
3USC
7
MBHL_ECOLI
L:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
R
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
41
PsiBlast_CBE
91.32
41%
-67
- C5 -
4UE3
5
MBHL_ECOLI
L:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
K
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
35
PsiBlast_CBE
91.18
41%
-68
- C5 -
3USE
9
MBHL_ECOLI
L:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
R
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
25
PsiBlast_CBE
91.16
43%
-77
- C5 -
4C3O
6
?
C:
[17-585]
----
R
R
I
V
V
D
P
V
T
R
I
E
G
H
M
R
C
E
V
N
I
D
S
N
N
V
I
T
N
A
V
S
T
G
T
M
W
R
G
L
E
V
I
L
K
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
T
H
A
L
T
S
I
R
A
V
E
N
A
L
G
I
A
I
P
D
N
A
N
C
I
R
N
M
M
Q
A
T
L
H
V
H
D
H
L
V
H
F
Y
H
L
H
A
L
D
W
V
D
V
V
A
A
L
K
A
D
P
H
Q
T
S
A
I
A
Q
S
L
S
A
W
P
L
S
S
-
P
G
Y
F
R
D
L
Q
N
R
L
K
R
F
I
E
S
G
Q
L
G
P
F
R
N
G
Y
W
--
G
H
P
A
M
K
L
P
P
E
A
N
L
L
A
V
A
H
Y
L
E
A
L
D
F
Q
K
E
I
V
K
I
H
T
V
F
G
G
K
N
P
H
P
N
W
L
-
V
G
G
V
PCAINLDE
T
G
A
V
G
A
---------
V
-
N
--------
M
E
R
L
N
L
V
S
S
I
I
Q
K
A
R
Q
F
C
E
Q
V
Y
L
P
D
V
L
L
I
A
S
Y
Y
K
D
W
A
K
I
G
G
G
L
S
S
M
-----
N
-----
L
L
A
Y
-------
G
E
F
P
--
D
---
N
P
----
N
----
D
Y
SASNL
L
L
P
R
-----
G
A
I
I
N
G
R
F
D
E
I
H
P
---
V
---
D
---
L
---
T
A
PDE
I
Q
E
F
V
T
H
S
W
Y
T
Y
G
N
G
N
N
D
K
G
L
H
P
W
D
G
L
T
E
P
QLVMGE
H
Y
K
G
T
K
----
T
F
I
E
Q
-------
V
D
E
S
A
K
Y
S
W
I
K
S
P
R
W
K
G
H
A
M
E
V
G
P
L
A
R
Y
L
I
G
Y
H
---
Q
N
K
P
E
F
K
E
P
V
D
Q
L
----------------
L
S
V
L
K
L
P
K
E
A
L
F
-
S
T
L
G
R
T
A
A
R
A
L
E
S
V
W
A
G
N
T
L
Q
Y
F
F
D
R
L
M
R
N
L
-
K
S
G
D
T
-
A
T
A
N
--
V
T
----
L
W
E
----
P
D
T
W
PTSA
K
G
V
G
F
S
----
E
A
--
P
R
G
A
L
G
H
W
I
K
I
A
N
Q
K
I
D
S
Y
Q
C
V
V
P
T
T
W
N
A
G
P
R
D
D
K
G
Q
I
G
A
Y
E
A
A
L
M
G
T
-
K
L
A
V
P
D
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
38
PsiBlast_CBE
91.08
41%
-68
- C5 -
3UQY
7
MBHL_ECOLI
M:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
R
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
24
PsiBlast_CBE
91.08
43%
-76
- C5 -
4C3O
5
?
E:
[17-585]
----
R
R
I
V
V
D
P
V
T
R
I
E
G
H
M
R
C
E
V
N
I
D
S
N
N
V
I
T
N
A
V
S
T
G
T
M
W
R
G
L
E
V
I
L
K
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
T
H
A
L
T
S
I
R
A
V
E
N
A
L
G
I
A
I
P
D
N
A
N
C
I
R
N
M
M
Q
A
T
L
H
V
H
D
H
L
V
H
F
Y
H
L
H
A
L
D
W
V
D
V
V
A
A
L
K
A
D
P
H
Q
T
S
A
I
A
Q
S
L
S
A
W
P
L
S
S
-
P
G
Y
F
R
D
L
Q
N
R
L
K
R
F
I
E
S
G
Q
L
G
P
F
R
N
G
Y
W
--
G
H
P
A
M
K
L
P
P
E
A
N
L
L
A
V
A
H
Y
L
E
A
L
D
F
Q
K
E
I
V
K
I
H
T
V
F
G
G
K
N
P
H
P
N
W
L
-
V
G
G
V
PCAINLDE
T
G
A
V
G
A
---------
V
-
N
--------
M
E
R
L
N
L
V
S
S
I
I
Q
K
A
R
Q
F
C
E
Q
V
Y
L
P
D
V
L
L
I
A
S
Y
Y
K
D
W
A
K
I
G
G
G
L
S
S
M
-----
N
-----
L
L
A
Y
-------
G
E
F
P
--
D
---
N
P
----
N
----
D
Y
SASNL
L
L
P
R
-----
G
A
I
I
N
G
R
F
D
E
I
H
P
---
V
---
D
---
L
---
T
A
PDE
I
Q
E
F
V
T
H
S
W
Y
T
Y
G
N
G
N
N
D
K
G
L
H
P
W
D
G
L
T
E
P
QLVMGE
H
Y
K
G
T
K
----
T
F
I
E
Q
-------
V
D
E
S
A
K
Y
S
W
I
K
S
P
R
W
K
G
H
A
M
E
V
G
P
L
A
R
Y
L
I
G
Y
H
---
Q
N
K
P
E
F
K
E
P
V
D
Q
L
----------------
L
S
V
L
K
L
P
K
E
A
L
F
-
S
T
L
G
R
T
A
A
R
A
L
E
S
V
W
A
G
N
T
L
Q
Y
F
F
D
R
L
M
R
N
L
-
K
S
G
D
T
-
A
T
A
N
--
V
T
----
L
W
E
----
P
D
T
W
PTSA
K
G
V
G
F
S
----
E
A
--
P
R
G
A
L
G
H
W
I
K
I
A
N
Q
K
I
D
S
Y
Q
C
V
V
P
T
T
W
N
A
G
P
R
D
D
K
G
Q
I
G
A
Y
E
A
A
L
M
G
T
-
K
L
A
V
P
D
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
40
PsiBlast_CBE
91.02
41%
-68
- C5 -
4UE3
6
MBHL_ECOLI
M:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
K
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
32
PsiBlast_CBE
90.94
41%
-68
- C5 -
4GD3
20
MBHL_ECOLI
K:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
R
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
34
PsiBlast_CBE
90.67
41%
-68
- C5 -
3USE
10
MBHL_ECOLI
M:
[16-582]
---
G
R
R
L
V
V
D
P
I
T
R
I
E
G
H
M
R
C
E
V
N
I
N
D
Q
N
V
I
T
N
A
V
S
C
G
T
M
F
R
G
L
E
I
I
L
Q
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
V
H
A
L
A
S
V
Y
A
I
E
D
A
I
G
I
K
V
P
D
N
A
N
I
I
R
N
I
M
L
A
T
L
W
C
H
D
H
L
V
H
F
Y
Q
L
A
G
M
D
W
I
D
V
L
D
A
L
K
A
D
P
R
K
T
S
E
L
A
Q
S
L
S
S
W
P
-
K
S
S
P
G
Y
F
F
D
V
Q
N
R
L
K
K
F
V
E
G
G
Q
L
G
I
F
R
N
G
Y
W
--
G
H
P
Q
Y
K
L
P
P
E
A
N
L
M
G
F
A
H
Y
L
E
A
L
D
F
Q
R
E
I
V
K
I
H
A
V
F
G
G
K
N
P
H
P
N
W
I
-
V
G
G
M
--------
P
C
A
I
N
I
DESGAVGA-
V
-
N
--------
M
E
R
L
N
L
V
Q
S
I
I
T
R
T
A
D
F
I
N
N
V
M
I
P
D
A
L
A
I
G
Q
F
--
N
K
P
W
S
E
I
G
T
G
L
S
-----
D
KCVLS
Y
G
A
F
-------
P
D
I
A
ND
F
---
G
E
----
K
----
S
L
-----
L
M
P
G
-----
G
A
V
I
N
G
D
F
N
N
V
L
P
VDL
V
---
D
---
P
---
Q
Q
---
V
Q
E
F
V
D
H
A
W
Y
R
Y
P
N
--
D
Q
V
G
R
H
P
F
D
G
I
T
D
P
------
W
Y
---
N
P
G
D
V
K
G
S
D
T
N
I
---
Q
Q
L
N
E
Q
E
R
Y
S
W
I
K
A
P
R
W
R
G
N
A
M
E
V
G
P
L
A
R
T
L
I
A
Y
H
---
K
G
D
A
A
T
V
E
S
V
D
R
M
----------------
M
S
A
L
N
L
P
L
S
G
I
Q
-
S
T
L
G
R
I
L
C
R
A
H
E
A
Q
W
A
A
G
K
L
Q
Y
F
F
D
K
L
M
T
N
L
-
K
N
G
N
L
-
A
T
A
S
--
T
E
KWEP
A
T
W
----
P
T
E
C
----
R
G
V
G
F
T
----
E
A
--
P
R
G
A
L
G
H
W
A
A
I
R
D
G
K
I
D
L
Y
Q
C
V
V
P
T
T
W
N
A
S
P
R
D
P
K
G
Q
I
G
A
Y
E
A
A
L
M
N
T
-
K
M
A
I
P
E
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
3
PsiBlast_PDB
90.39
43%
-76
- C5 -
4C3O
7
?
A:
[17-585]
----
R
R
I
V
V
D
P
V
T
R
I
E
G
H
M
R
C
E
V
N
I
D
S
N
N
V
I
T
N
A
V
S
T
G
T
M
W
R
G
L
E
V
I
L
K
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
T
H
A
L
T
S
I
R
A
V
E
N
A
L
G
I
A
I
P
D
N
A
N
C
I
R
N
M
M
Q
A
T
L
H
V
H
D
H
L
V
H
F
Y
H
L
H
A
L
D
W
V
D
V
V
A
A
L
K
A
D
P
H
Q
T
S
A
I
A
Q
S
L
S
A
W
P
L
S
S
-
P
G
Y
F
R
D
L
Q
N
R
L
K
R
F
I
E
S
G
Q
L
G
P
F
R
N
G
Y
W
--
G
H
P
A
M
K
L
P
P
E
A
N
L
L
A
V
A
H
Y
L
E
A
L
D
F
Q
K
E
I
V
K
I
H
T
V
F
G
G
K
N
P
H
P
N
W
L
-
V
G
G
V
PCAINLDE
T
G
A
V
G
A
---------
V
-
N
--------
M
E
R
L
N
L
V
S
S
I
I
Q
K
A
R
Q
F
C
E
Q
V
Y
L
P
D
V
L
L
I
A
S
Y
Y
K
D
W
A
K
I
G
G
G
L
S
S
M
-----
N
-----
L
L
A
Y
-------
G
E
F
P
--
D
---
N
P
----
N
----
D
Y
SASNL
L
L
P
R
-----
G
A
I
I
N
G
R
F
D
E
I
H
P
---
V
---
D
---
L
---
T
A
PD
E
I
Q
E
F
V
T
H
S
W
Y
T
Y
G
N
G
N
N
D
K
G
L
H
P
W
D
G
L
T
E
P
Q
L
V
M
G
E
H
Y
K
G
T
K
----
T
F
I
E
Q
-------
V
D
E
S
A
K
Y
S
W
I
K
S
P
R
W
K
G
H
A
M
E
V
G
P
L
A
R
Y
L
I
G
Y
H
---
Q
N
K
P
E
F
K
E
P
V
D
Q
L
----------------
L
S
V
L
K
L
P
K
E
A
L
F
-
S
T
L
G
R
T
A
A
R
A
L
E
S
V
W
A
G
N
T
L
Q
Y
F
F
D
R
L
M
R
N
L
-
K
S
G
D
T
-
A
T
A
N
--
V
T
----
L
W
E
----
P
D
T
W
PT
S
A
K
G
V
G
F
S
----
E
A
--
P
R
G
A
L
G
H
W
I
K
I
A
N
Q
K
I
D
S
Y
Q
C
V
V
P
T
T
W
N
A
G
P
R
D
D
K
G
Q
I
G
A
Y
E
A
A
L
M
G
T
-
K
L
A
V
P
D
Q
P
L
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
68
PsiBlast_CBE
90.26
43%
-75
- C5 -
4UCW
6
?
S:
[30-563]
------
I
V
V
D
P
I
T
R
I
E
G
H
L
R
I
M
V
E
V
E
N
G
K
V
-
K
D
A
W
S
S
S
Q
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
A
C
G
V
C
T
Y
V
H
A
L
A
S
S
R
C
V
D
D
A
V
K
V
S
I
P
A
N
A
R
M
M
R
N
L
V
M
A
S
Q
Y
L
H
D
H
L
V
H
F
Y
H
L
H
A
L
D
W
V
D
V
T
A
A
L
K
A
D
P
N
K
A
A
K
L
A
A
S
I
A
P
A
R
P
G
N
S
A
K
A
L
K
A
V
Q
D
K
L
K
A
F
V
E
S
G
Q
L
G
I
F
T
N
A
Y
F
LG
G
H
K
A
Y
Y
L
P
P
E
V
D
L
I
A
T
A
H
Y
L
E
A
L
H
M
Q
V
K
A
A
S
A
M
A
I
L
G
G
K
N
P
H
T
Q
F
T
V
V
G
G
C
--------
S
N
Y
Q
G
L
---------
T
K
D
--------
P
--
L
A
N
Y
L
A
L
S
K
E
V
C
Q
F
V
N
E
C
Y
I
P
D
L
L
A
V
A
G
F
Y
K
D
W
G
G
I
---
G
G
T
S
-----
N
-----
Y
L
A
F
-------
G
E
F
A
--
T
DDS
S
P
----
E
----
K
H
-----
L
A
T
S
QFPS-
G
V
I
T
G
R
D
L
G
K
V
D
N
---
V
---
D
---
L
---
G
A
---
I
Y
E
D
V
K
Y
S
W
Y
A
P
G
G
-
D
G
K
---
H
P
Y
D
G
V
T
D
P
------
K
Y
T
K
L
D
D
------------------
K
D
H
Y
S
W
M
K
A
P
R
Y
K
G
K
A
M
E
V
G
P
L
A
R
T
F
I
A
Y
A
---
K
G
Q
P
D
F
K
K
V
V
D
M
V
----------------
L
G
K
L
S
V
P
A
T
A
L
H
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
I
V
C
A
N
M
E
K
W
I
K
E
M
A
D
S
G
-
A
K
D
N
T
-
L
C
A
K
--
W
E
----
M
P
------
E
E
S
----
K
G
V
G
L
A
----
D
A
--
P
R
G
A
L
S
H
W
I
R
I
K
G
K
K
I
D
N
F
Q
L
V
V
P
S
T
W
N
L
G
P
R
G
A
Q
G
D
K
S
P
V
E
E
A
L
I
G
T
-
P
I
A
D
P
K
R
P
V
E
I
L
R
T
V
H
A
F
D
P
C
I
A
C
G
V
H
---------------------
16
PsiBlast_PDB
89.81
46%
-78
- C5 -
1WUJ
4
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
11
PsiBlast_PDB
89.80
46%
-76
- C5 -
1UBO
5
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
8
PsiBlast_PDB
89.65
46%
-76
- C5 -
1UBK
9
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
102
Fugue
89.48
47%
-84
- C5 -
1H2A
4
PHNL_DESVM
L:
[19-552]
SS
Y
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
-
G
K
V
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
K
--
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
C
-
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
---
K
D
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
GEFPKDE
Y
D
---------
L
----
N
----
S
R
-----
F
F
K
P
-----
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
-
G
A
-
E
A
---
R
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
------------------
H
G
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
-
A
K
G
D
N
-
V
I
C
A
---
P
----
W
E
M
----
P
K
Q
A
----
E
G
V
G
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
N
V
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
9
PsiBlast_PDB
89.46
46%
-78
- C5 -
1UBL
7
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
18
PsiBlast_PDB
89.43
46%
-76
- C5 -
1WUL
6
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
7
PsiBlast_PDB
89.34
46%
-77
- C5 -
1UBJ
5
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
17
PsiBlast_PDB
89.32
46%
-78
- C5 -
1WUK
4
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
12
PsiBlast_PDB
89.30
46%
-75
- C5 -
1UBR
5
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
6
PsiBlast_PDB
89.24
46%
-79
- C5 -
1UBH
12
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
13
PsiBlast_PDB
89.23
46%
-76
- C5 -
1UBT
4
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
20
PsiBlast_PDB
89.22
45%
-77
- C5 -
1WUI
5
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
10
PsiBlast_PDB
89.22
46%
-77
- C5 -
1UBM
6
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
15
PsiBlast_PDB
89.14
46%
-78
- C5 -
1H2R
4
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
N
V
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
14
PsiBlast_PDB
89.07
46%
-77
- C5 -
1UBU
4
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
19
PsiBlast_PDB
89.05
45%
-77
- C5 -
1WUH
4
PHNL_DESVM
L:
[4-534]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
K
L
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
2
PsiBlast_PDB
88.80
45%
-80
- C5 -
1H2A
4
PHNL_DESVM
L:
[22-552]
---
S
G
P
I
V
V
D
P
V
T
R
I
E
G
H
L
R
I
E
V
E
V
E
N
G
K
V
-
K
N
A
Y
S
S
S
T
L
F
R
G
L
E
I
I
L
K
G
R
D
P
R
D
A
Q
H
F
T
Q
R
T
C
G
V
C
T
Y
T
H
A
L
A
S
T
R
C
V
D
N
A
V
G
V
H
I
P
K
N
A
T
Y
I
R
N
L
V
L
G
A
Q
Y
L
H
D
H
I
V
H
F
Y
H
L
H
A
L
D
F
V
D
V
T
A
A
L
K
A
D
P
A
K
A
A
K
V
A
S
S
I
S
P
R
--
K
T
T
A
A
D
L
K
A
V
Q
D
K
L
K
T
F
V
E
T
G
Q
L
G
P
F
T
N
A
Y
F
LG
G
H
P
A
Y
Y
L
D
P
E
T
N
L
I
A
T
A
H
Y
L
E
A
L
R
L
Q
V
K
A
A
R
A
M
A
V
F
G
A
K
N
P
H
T
Q
F
T
V
V
G
G
V
--------
T
-
C
Y
D
A
---------
L
-
T
--------
P
Q
R
I
A
E
F
E
A
L
W
K
E
T
K
A
F
V
D
E
V
Y
I
P
D
L
L
V
V
A
A
A
Y
K
D
---
W
T
Q
Y
G
G
T
D
-----
N
-----
F
I
T
F
-------
G
E
----
F
---
P
K
----
D
----
E
Y
-----
D
L
N
S
RFFKP
G
V
V
F
K
R
D
F
K
N
I
K
P
---
F
---
D
---
K
---
M
Q
---
I
E
E
H
V
R
H
S
W
Y
E
G
A
E
-
A
R
----
H
P
W
K
G
Q
T
Q
P
------
K
Y
T
D
L
H
G
------------------
D
D
R
Y
S
W
M
K
A
P
R
Y
M
G
E
P
M
E
T
G
P
L
A
Q
V
L
I
A
Y
S
---
Q
G
H
P
K
V
K
A
V
T
D
A
V
----------------
L
A
K
L
G
V
G
P
E
A
L
F
-
S
T
L
G
R
T
A
A
R
G
I
E
T
A
V
I
A
E
Y
V
G
V
M
L
Q
E
Y
K
D
N
I
A
K
G
D
N
V
-
I
C
A
P
--
W
E
----
M
P
K
----
Q
A
E
G
----
V
G
--
F
V
----
N
A
--
P
R
G
G
L
S
H
W
I
R
I
E
D
G
K
I
G
N
F
Q
L
V
V
P
S
T
W
T
L
G
P
R
C
D
K
N
N
V
S
P
V
E
A
S
L
I
G
T
-
P
V
A
D
A
K
R
P
V
E
I
L
R
T
V
H
S
F
D
P
C
I
A
C
G
V
H
---------------------
27
PsiBlast_CBE
87.46
41%
-74
- C5 -
4IUC
5
MBHL_CUPNH
L:
[16-603]
----
R
R
I
V
V
D
P
V
T
R
I
E
G
H
M
R
C
E
V
N
V
D
A
N
N
V
I
R
N
A
V
S
T
G
T
M
W
R
G
L
E
V
I
L
K
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
C
H
A
L
A
S
V
R
A
V
E
N
A
L
D
I
R
I
P
K
N
A
H
L
I
R
E
I
M
A
K
T
L
Q
V
H
D
H
A
V
H
F
Y
H
L
H
A
L
D
W
V
D
V
M
S
A
L
K
A
D
P
K
R
T
S
E
L
Q
Q
L
V
S
P
A
H
P
L
S
S
A
G
Y
F
R
D
I
Q
N
R
L
K
R
F
V
E
S
G
Q
L
G
P
F
M
N
G
Y
W
--
G
S
K
A
Y
V
L
P
P
E
A
N
L
M
A
V
T
H
Y
L
E
A
L
D
L
Q
K
E
W
V
K
I
H
T
I
F
G
G
K
N
P
H
P
N
Y
L
-
V
G
G
V
--------
P
C
A
I
N
L
DGIGAASAP
V
-
N
--------
M
E
R
L
S
F
V
K
A
R
I
D
E
I
I
E
F
N
K
N
V
Y
V
P
D
V
L
A
I
G
T
L
Y
-
K
Q
A
G
W
L
Y
G
G
G
L
A
ATNVL
D
-----
Y
G
E
Y
-------
P
N
V
A
--
Y
---
N
K
----
S
----
T
D
-----
Q
L
P
G
-----
G
A
I
L
N
G
N
W
D
E
V
F
P
---
V
DPR
D
---
S
---
Q
Q
---
V
Q
E
F
V
S
H
S
W
Y
K
Y
A
D
--
E
S
V
G
L
H
P
W
D
G
V
T
E
P
------
N
Y
--
V
L
G
A
N
T
K
G
T
R
T
R
I
---
E
Q
I
D
E
S
A
K
Y
S
W
I
K
S
P
R
W
R
G
H
A
M
E
V
G
P
L
S
R
Y
I
L
A
Y
A
HAR
S
G
N
K
Y
A
E
R
P
K
E
Q
L
EYSAQMINSAIPKALG
L
P
E
T
Q
Y
T
L
K
Q
L
L
P
S
T
I
G
R
T
L
A
R
A
L
E
S
Q
Y
C
G
E
M
M
H
S
D
W
H
D
L
V
A
N
I
-
R
A
G
D
T
-
A
T
A
----
N
----
V
D
K
WDPA
T
W
P
L
----
Q
A
K
G
V
G
----
T
V
AA
P
R
G
A
L
G
H
W
I
R
I
K
D
G
R
I
E
N
Y
Q
C
V
V
P
T
T
W
N
G
S
P
R
D
Y
K
G
Q
I
G
A
F
E
A
S
L
M
N
T
-
P
M
V
N
P
E
Q
P
V
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
28
PsiBlast_CBE
87.44
41%
-74
- C5 -
4IUB
9
MBHL_CUPNH
L:
[16-603]
----
R
R
I
V
V
D
P
V
T
R
I
E
G
H
M
R
C
E
V
N
V
D
A
N
N
V
I
R
N
A
V
S
T
G
T
M
W
R
G
L
E
V
I
L
K
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
C
H
A
L
A
S
V
R
A
V
E
N
A
L
D
I
R
I
P
K
N
A
H
L
I
R
E
I
M
A
K
T
L
Q
V
H
D
H
A
V
H
F
Y
H
L
H
A
L
D
W
V
D
V
M
S
A
L
K
A
D
P
K
R
T
S
E
L
Q
Q
L
V
S
P
A
H
P
L
S
S
A
G
Y
F
R
D
I
Q
N
R
L
K
R
F
V
E
S
G
Q
L
G
P
F
M
N
G
Y
W
--
G
S
K
A
Y
V
L
P
P
E
A
N
L
M
A
V
T
H
Y
L
E
A
L
D
L
Q
K
E
W
V
K
I
H
T
I
F
G
G
K
N
P
H
P
N
Y
L
-
V
G
G
V
--------
P
C
A
I
N
L
DGIGAASAP
V
-
N
--------
M
E
R
L
S
F
V
K
A
R
I
D
E
I
I
E
F
N
K
N
V
Y
V
P
D
V
L
A
I
G
T
L
Y
-
K
Q
A
G
W
L
Y
G
G
G
L
A
ATNVL
D
-----
Y
G
E
Y
-------
P
N
V
A
--
Y
---
N
K
----
S
----
T
D
-----
Q
L
P
G
-----
G
A
I
L
N
G
N
W
D
E
V
F
P
---
V
DPR
D
---
S
---
Q
Q
---
V
Q
E
F
V
S
H
S
W
Y
K
Y
A
D
--
E
S
V
G
L
H
P
W
D
G
V
T
E
P
------
N
Y
--
V
L
G
A
N
T
K
G
T
R
T
R
I
---
E
Q
I
D
E
S
A
K
Y
S
W
I
K
S
P
R
W
R
G
H
A
M
E
V
G
P
L
S
R
Y
I
L
A
Y
A
HAR
S
G
N
K
Y
A
E
R
P
K
E
Q
L
EYSAQMINSAIPKALG
L
P
E
T
Q
Y
T
L
K
Q
L
L
P
S
T
I
G
R
T
L
A
R
A
L
E
S
Q
Y
C
G
E
M
M
H
S
D
W
H
D
L
V
A
N
I
-
R
A
G
D
T
-
A
T
A
----
N
----
V
D
K
WDPA
T
W
P
L
----
Q
A
K
G
V
G
----
T
V
AA
P
R
G
A
L
G
H
W
I
R
I
K
D
G
R
I
E
N
Y
Q
C
V
V
P
T
T
W
N
G
S
P
R
D
Y
K
G
Q
I
G
A
F
E
A
S
L
M
N
T
-
P
M
V
N
P
E
Q
P
V
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
29
PsiBlast_CBE
87.24
41%
-74
- C5 -
3RGW
4
MBHL_CUPNH
L:
[16-603]
----
R
R
I
V
V
D
P
V
T
R
I
E
G
H
M
R
C
E
V
N
V
D
A
N
N
V
I
R
N
A
V
S
T
G
T
M
W
R
G
L
E
V
I
L
K
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
C
H
A
L
A
S
V
R
A
V
E
N
A
L
D
I
R
I
P
K
N
A
H
L
I
R
E
I
M
A
K
T
L
Q
V
H
D
H
A
V
H
F
Y
H
L
H
A
L
D
W
V
D
V
M
S
A
L
K
A
D
P
K
R
T
S
E
L
Q
Q
L
V
S
P
A
H
P
L
S
S
A
G
Y
F
R
D
I
Q
N
R
L
K
R
F
V
E
S
G
Q
L
G
P
F
M
N
G
Y
W
--
G
S
K
A
Y
V
L
P
P
E
A
N
L
M
A
V
T
H
Y
L
E
A
L
D
L
Q
K
E
W
V
K
I
H
T
I
F
G
G
K
N
P
H
P
N
Y
L
-
V
G
G
V
--------
P
C
A
I
N
L
DGIGAASAP
V
-
N
--------
M
E
R
L
S
F
V
K
A
R
I
D
E
I
I
E
F
N
K
N
V
Y
V
P
D
V
L
A
I
G
T
L
Y
-
K
Q
A
G
W
L
Y
G
G
G
L
A
ATNVL
D
-----
Y
G
E
Y
-------
P
N
V
A
--
Y
---
N
K
----
S
----
T
D
-----
Q
L
P
G
-----
G
A
I
L
N
G
N
W
D
E
V
F
P
---
V
DPR
D
---
S
---
Q
Q
---
V
Q
E
F
V
S
H
S
W
Y
K
Y
A
D
--
E
S
V
G
L
H
P
W
D
G
V
T
E
P
------
N
Y
--
V
L
G
A
N
T
K
G
T
R
T
R
I
---
E
Q
I
D
E
S
A
K
Y
S
W
I
K
S
P
R
W
R
G
H
A
M
E
V
G
P
L
S
R
Y
I
L
A
Y
A
HAR
S
G
N
K
Y
A
E
R
P
K
E
Q
L
EYSAQMINSAIPKALG
L
P
E
T
Q
Y
T
L
K
Q
L
L
P
S
T
I
G
R
T
L
A
R
A
L
E
S
Q
Y
C
G
E
M
M
H
S
D
W
H
D
L
V
A
N
I
-
R
A
G
D
T
-
A
T
A
----
N
----
V
D
K
WDPA
T
W
P
L
----
Q
A
K
G
V
G
----
T
V
AA
P
R
G
A
L
G
H
W
I
R
I
K
D
G
R
I
E
N
Y
Q
C
V
V
P
T
T
W
N
G
S
P
R
D
Y
K
G
Q
I
G
A
F
E
A
S
L
M
N
T
-
P
M
V
N
P
E
Q
P
V
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------
26
PsiBlast_CBE
87.19
41%
-75
- C5 -
4TTT
7
MBHL_CUPNH
L:
[16-603]
----
R
R
I
V
V
D
P
V
T
R
I
E
G
H
M
R
C
E
V
N
V
D
A
N
N
V
I
R
N
A
V
S
T
G
T
M
W
R
G
L
E
V
I
L
K
G
R
D
P
R
D
A
W
A
F
V
E
R
I
C
G
V
C
T
G
C
H
A
L
A
S
V
R
A
V
E
N
A
L
D
I
R
I
P
K
N
A
H
L
I
R
E
I
M
A
K
T
L
Q
V
H
D
H
A
V
H
F
Y
H
L
H
A
L
D
W
V
D
V
M
S
A
L
K
A
D
P
K
R
T
S
E
L
Q
Q
L
V
S
P
A
H
P
L
S
S
A
G
Y
F
R
D
I
Q
N
R
L
K
R
F
V
E
S
G
Q
L
G
P
F
M
N
G
Y
W
--
G
S
K
A
Y
V
L
P
P
E
A
N
L
M
A
V
T
H
Y
L
E
A
L
D
L
Q
K
E
W
V
K
I
H
T
I
F
G
G
K
N
P
H
P
N
Y
L
-
V
G
G
V
--------
P
C
A
I
N
L
DAASAP---
V
-
N
--------
M
E
R
L
S
F
V
K
A
R
I
D
E
I
I
E
F
N
K
N
V
Y
V
P
D
V
L
A
I
G
T
L
Y
-
K
Q
A
G
W
L
Y
G
G
G
L
A
ATNVL
D
-----
Y
G
E
Y
-------
P
N
V
A
--
Y
---
N
K
----
S
----
T
D
-----
Q
L
P
G
-----
G
A
I
L
N
G
N
W
D
E
V
F
P
---
V
DPR
D
---
S
---
Q
Q
---
V
Q
E
F
V
S
H
S
W
Y
K
Y
A
D
--
E
S
V
G
L
H
P
W
D
G
V
T
E
P
------
N
Y
--
V
L
G
A
N
T
K
G
T
R
T
R
I
---
E
Q
I
D
E
S
A
K
Y
S
W
I
K
S
P
R
W
R
G
H
A
M
E
V
G
P
L
S
R
Y
I
L
A
Y
A
HAR
S
G
N
K
Y
A
E
R
P
K
E
Q
L
EYSAQMINSAIPKALG
L
P
E
T
Q
Y
T
L
K
Q
L
L
P
S
T
I
G
R
T
L
A
R
A
L
E
S
Q
Y
C
G
E
M
M
H
S
D
W
H
D
L
V
A
N
I
-
R
A
G
D
T
-
A
T
A
----
N
----
V
D
K
WDPA
T
W
P
L
----
Q
A
K
G
V
G
----
T
V
AA
P
R
G
A
L
G
H
W
I
R
I
K
D
G
R
I
E
N
Y
Q
C
V
V
P
T
T
W
N
G
S
P
R
D
Y
K
G
Q
I
G
A
F
E
A
S
L
M
N
T
-
P
M
V
N
P
E
Q
P
V
E
I
L
R
T
L
H
S
F
D
P
C
L
A
C
S
T
H
---------------------