@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0585: (2015-12-16 )
MKIGWIGLGAMGTPMATRLRDAGLEVSVYNRTESKAAPLKEKGVAVYTSPIDLAAKVDLVFTMLSDKAAIDAVLAPKFWEQMSKKIVVNMSTIAPLESLSLEKIAQKHQATYLEAPVSGSVGAAKAGALLILAAGDEEVISKLKPVLAHLGSQTFYLGKVGQGTGAKLSINSLLAQMGVAYSEALLLAKRLGVDAESFLQIIGQSGMNSPLFQAKKGMWLQDNYPAAFSLKLMAKDIRLAKNEAGEAMKLPFLFQAEELYSQAEKSGLGGLDMAAVYHYLEKGEH
Atome Classification :
(24 SA)
----.........10........20........30........40........50........60.....-...70...--...--..80.-..--.--.-----...90........100........110.......120.......130.......140.......150.......160.......170.......180.......190.......200.-------......210.....-..220.......230.......240....-.-..--250--...--....260.......270.......280...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----
M
K
I
G
W
I
G
LGAMG
T
P
M
A
T
R
L
R
DAG
L
E
V
S
V
Y
NRTESKAAPLKEK
G
V
A
V
Y
TSPI
D
L
A
A
K
V
D
L
V
F
T
MLSD-
K
A
A
I
D
A
V
L
--
A
P
K
--
F
W
E
Q
M
-
S
K
--
K
--
I
-----
V
V
N
MSTIA
P
L
E
SL
S
L
-
E
K
I
A
Q
K
HQA
T
Y
LEAPVSGSVGAAKA
G
A
L
L
I
L
AAG
D
E
E
V
I
S
K
L
K
P
V
L
A
H
LGSQ
T
F
Y
L
G
KVGQGTG
A
K
L
S
I
N
S
L
L
A
Q
M
G
V
A
Y
S
E
A
L
L
L
A
K
R
LGV
D
A
E
S
F
L
Q
I
I
G
-------QSGMNSP
L
F
Q
AKKG-
M
W
LQDNYPA
A
F
S
L
K
L
M
A
K
D
I
R
LAKNEAGE-A-MK--L
P
F
--
L
F
Q
--
A
E
E
L
Y
S
Q
A
E
KSGLGG
L
D
M
A
A
V
Y
H
Y
L
EKGEH
94
HHSearch
89.55
37%
-104
- C1 -
3DOJ
1
GLYR1_ARATH
A:
[22-308]
----
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
H
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
T
I
A
M
L
S
D
-
P
C
A
A
L
S
V
V
--
F
D
K
GG
V
L
E
Q
I
C
E
G
--
K
--
G
-----
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
-
N
E
A
I
T
G
K
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
S
F
Y
L
G
Q
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
L
D
-------
L
G
A
M
T
N
P
M
F
K
G
K
G
P
S
M
N
-
K
S
S
Y
P
P
A
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
-
N
A
V
S
--
M
P
V
--
A
A
A
--
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
F
S
R
-
79
Fugue
89.12
36%
-104
- C1 -
3DOJ
1
GLYR1_ARATH
A:
[18-309]
GSHM
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
H
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
T
I
A
M
L
S
D
-
P
C
A
A
L
S
V
V
--
F
D
K
GG
V
L
E
Q
I
-
C
E
G-
K
--
G
-----
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
-
N
E
A
I
T
G
K
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
S
F
Y
L
G
Q
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
L
D
-------
L
G
A
M
T
N
P
M
F
K
G
K
G
P
-
S
M
N
K
S
S
Y
P
P
A
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
-
N
A
V
S
--
M
P
V
--
A
A
A
--
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
F
S
R
-
2
PsiBlast_PDB
88.25
37%
-105
- C1 -
3DOJ
1
GLYR1_ARATH
A:
[22-301]
----
M
E
V
G
F
L
G
L
G
I
M
G
K
A
M
S
M
N
L
L
K
N
G
F
K
V
T
V
W
N
R
T
L
S
K
C
D
E
L
V
E
H
G
A
S
V
C
E
S
P
A
E
V
I
K
K
C
K
Y
T
I
A
M
L
S
D
-
P
C
A
A
L
S
V
V
--
F
D
K
GG
V
L
E
Q
I
-
C
E
G-
K
--
G
-----
Y
I
D
M
S
T
V
D
A
E
T
S
L
K
I
-
N
E
A
I
T
G
K
G
G
R
F
V
E
G
P
V
S
G
S
K
K
P
A
E
D
G
Q
L
I
I
L
A
A
G
D
K
A
L
F
E
E
S
I
P
A
F
D
V
L
G
K
R
S
F
Y
L
G
Q
V
G
N
G
A
K
M
K
L
I
V
N
M
I
M
G
S
M
M
N
A
F
S
E
G
L
V
L
A
D
K
S
G
L
S
S
D
T
L
L
D
I
L
D
-------
L
G
A
M
T
N
P
M
F
K
G
K
G
P
-
S
M
N
K
S
S
Y
P
P
A
F
P
L
K
H
Q
Q
K
D
M
R
L
A
L
A
L
G
D
E
N
A
-
V
S
--
M
P
V
--
A
A
A
--
A
N
E
A
F
K
K
A
R
S
L
G
L
G
D
L
D
F
S
A
V
I
E
A
V
K
F
S
R
-
1
PsiBlast_PDB
85.53
36%
-102
- C1 -
3PDU
3
?
A:
[5-286]
-------
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
-
P
A
A
A
R
E
V
C
FG
A
N
G
--
V
L
E
G
I
-
G
G
G-
R
--
G
-----
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
-
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
-------
A
G
A
M
A
N
P
M
F
K
G
K
G
Q
-
M
L
L
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
E
L
G
D
-
R
-
L
G
--
Q
P
L
H
G
A
A
T
--
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
A
---
27
PsiBlast_CBE
85.51
36%
-106
- C1 -
3PDU
5
?
B:
[5-286]
-------
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
-
P
A
A
A
R
E
V
C
FG
A
N
G
--
V
L
E
G
I
-
G
G
G-
R
--
G
-----
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
-
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
-------
A
G
A
M
A
N
P
M
F
K
G
K
G
Q
-
M
L
L
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
E
L
G
D
-
R
-
L
G
--
Q
P
L
H
G
A
A
T
--
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
A
---
26
PsiBlast_CBE
85.47
36%
-104
- C1 -
3PDU
3
?
C:
[5-286]
-------
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
-
P
A
A
A
R
E
V
C
FG
A
N
G
--
V
L
E
G
I
-
G
G
G-
R
--
G
-----
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
-
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
-------
A
G
A
M
A
N
P
M
F
K
G
K
G
Q
-
M
L
L
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
E
L
G
D
-
R
-
L
G
--
Q
P
L
HG
A
A
T
--
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
A
---
22
PsiBlast_CBE
85.35
36%
-105
- C1 -
3PDU
2
?
G:
[5-286]
-------
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
-
P
A
A
A
R
E
V
C
FG
A
N
G
--
V
L
E
G
I
-
G
G
G-
R
--
G
-----
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
-
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
-------
A
G
A
M
A
N
P
M
F
K
G
K
G
Q
-
M
L
L
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
E
L
G
D
-
R
-
L
G
--
Q
P
L
HG
A
A
T
--
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
----
23
PsiBlast_CBE
85.31
36%
-102
- C1 -
3PDU
4
?
F:
[5-286]
-------
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
-
P
A
A
A
R
E
V
C
FG
A
N
G
--
V
L
E
G
I
-
G
G
G-
R
--
G
-----
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
-
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
-------
A
G
A
M
A
N
P
M
F
K
G
K
G
Q
-
M
L
L
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
E
L
G
D
-
R
-
L
G
--
Q
P
L
HG
A
A
T
--
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
A
---
25
PsiBlast_CBE
85.28
36%
-102
- C1 -
3PDU
4
?
D:
[5-286]
-------
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
-
P
A
A
A
R
E
V
C
FG
A
N
G
--
V
L
E
G
I
-
G
G
G-
R
--
G
-----
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
-
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
-------
A
G
A
M
A
N
P
M
F
K
G
K
G
Q
-
M
L
L
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
E
L
G
D
-
R
-
L
G
--
Q
P
L
HG
A
A
T
--
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
A
---
24
PsiBlast_CBE
84.78
36%
-102
- C1 -
3PDU
2
?
E:
[5-286]
-------
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
-
P
A
A
A
R
E
V
C
FG
A
N
G
--
V
L
E
G
I
-
G
G
G-
R
--
G
-----
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
-
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
-------
A
G
A
M
A
N
P
M
F
K
G
K
G
Q
-
M
L
L
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
E
L
G
D
-
R
-
L
G
--
Q
P
L
HG
A
A
T
--
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
A
---
21
PsiBlast_CBE
84.67
36%
-102
- C1 -
3PDU
3
?
H:
[5-286]
-------
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
-
P
A
A
A
R
E
V
C
FG
A
N
G
--
V
L
E
G
I
-
G
G
G-
R
--
G
-----
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
-
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
-------
A
G
A
M
A
N
P
M
F
K
G
K
G
Q
-
M
L
L
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
E
L
G
D
-
R
-
L
G
--
Q
P
L
HG
A
A
T
--
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
A
---
89
HHSearch
84.66
35%
-100
* C1 *
3PDU
3
?
A:
[2-286]
----
T
T
Y
G
F
L
G
L
G
I
M
G
G
P
M
A
A
N
L
V
R
A
G
F
D
V
T
V
W
N
R
N
P
A
K
C
A
P
L
V
A
L
G
A
R
Q
A
S
S
P
A
E
V
C
A
A
C
D
I
T
I
A
M
L
A
D
-
P
A
A
A
R
E
V
C
--
F
G
A
NG
V
L
E
G
I
G
G
G
--
R
--
G
-----
Y
I
D
M
S
T
V
D
D
E
T
S
T
A
I
-
G
A
A
V
T
A
R
G
G
R
F
L
E
A
P
V
S
G
T
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
Q
S
L
F
T
D
A
G
P
A
F
A
A
L
G
K
K
C
L
H
L
G
E
V
G
Q
G
A
R
M
K
L
V
V
N
M
I
M
G
Q
M
M
T
A
L
G
E
G
M
A
L
G
R
N
C
G
L
D
G
G
Q
L
L
E
V
L
D
-------
A
G
A
M
A
N
P
M
F
K
G
K
G
Q
M
L
L
-
S
G
E
F
P
T
S
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
E
L
G
D
R
-
L
G
Q
P
--
L
H
G
--
A
A
T
--
A
N
E
S
F
K
R
A
R
A
A
G
H
A
D
E
D
F
A
A
V
F
R
V
L
E
A
---
5
PsiBlast_PDB
84.62
35%
-102
- C1 -
3W6Z
1
?
A:
[21-303]
----
M
R
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
A
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
V
I
V
M
V
S
D
-
A
P
D
V
E
Q
V
L
F-
G
P
S
--
G
V
V
E
G
-
A
R
--
P
G
L
I
-----
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
-
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
Y
M
G
P
V
G
Y
G
Q
A
M
M
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
T
-------
R
G
A
A
R
S
G
A
I
E
L
Y
L
P
-
K
L
L
K
G
D
L
S
P
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
-
V
K
--
L
P
G
--
A
E
L
--
A
Y
E
L
Y
R
K
M
V
E
D
G
A
G
S
L
G
I
H
A
L
G
F
Y
------
90
HHSearch
83.83
35%
-102
- C1 -
3PEF
6
?
A:
[2-286]
----
Q
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
-
P
A
A
A
E
E
V
C
--
F
G
K
HG
V
L
E
G
I
G
E
G
--
R
--
G
-----
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
-
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
D
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
-------
A
G
A
M
A
N
P
M
F
A
L
K
G
G
L
I
R
-
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
A
L
G
D
R
-
V
G
Q
P
--
L
V
A
--
S
A
A
--
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
R
---
33
PsiBlast_CBE
83.21
34%
-102
- C1 -
3PEF
2
?
C:
[3-287]
-----
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
-
P
A
A
A
E
E
V
C
--
F
G
K
HG
V
L
E
G
I
-
G
E
G-
R
--
G
-----
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
-
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
D
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
-------
A
G
A
M
A
N
P
M
F
A
L
K
G
G
-
L
I
R
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
A
L
G
D
-
R
-
V
G
--
Q
P
L
--
V
A
S
AA
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
R
---
3
PsiBlast_PDB
83.04
34%
-104
- C1 -
3PEF
6
?
A:
[3-287]
-----
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
-
P
A
A
A
E
E
V
C
--
F
G
K
HG
V
L
E
G
I
-
G
E
G
-
R
--
G
-----
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
-
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
D
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
-------
A
G
A
M
A
N
P
M
F
A
L
K
G
G
-
L
I
R
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
A
L
G
D
-
R
-
V
G
--
Q
P
L
--
V
A
S
A
A
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
R
---
4
PsiBlast_PDB
82.95
35%
-103
- C1 -
3WS7
3
?
A:
[21-303]
----
M
R
V
G
F
I
G
L
G
I
M
G
G
P
M
A
T
H
L
L
K
A
G
F
L
A
A
V
Y
N
R
T
R
E
K
T
K
P
F
A
E
A
G
V
Y
V
A
E
S
P
A
D
L
A
K
R
V
D
V
V
I
V
M
V
S
D
-
A
P
D
V
E
Q
V
L
F-
G
P
S
--
G
V
V
E
G
-
A
R
--
P
G
L
I
-----
V
V
D
M
S
T
N
S
P
D
W
A
R
K
F
A
E
R
L
A
Q
-
Y
G
I
E
F
L
D
A
P
V
T
G
G
Q
K
G
A
I
E
G
T
L
T
I
M
V
G
G
K
E
E
L
F
H
R
L
L
P
I
F
K
A
M
G
R
D
I
V
Y
M
G
P
V
G
Y
G
Q
A
M
K
L
V
N
Q
V
V
V
A
L
N
T
V
A
M
V
E
G
L
K
L
A
K
A
L
G
L
D
M
D
K
V
A
E
V
L
T
----------
A
R
S
G
A
I
E
L
Y
L
P
-
K
L
L
K
G
D
L
S
P
G
F
K
A
E
H
L
K
K
D
L
G
Y
V
L
E
E
A
R
K
R
G
-
V
K
--
L
P
G
--
A
E
L
--
A
Y
E
L
Y
R
K
M
V
E
D
G
A
G
S
L
G
I
H
A
L
G
F
Y
------
34
PsiBlast_CBE
82.72
34%
-103
- C1 -
3PEF
2
?
B:
[3-287]
-----
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
-
P
A
A
A
E
E
V
C
--
F
G
K
HG
V
L
E
G
I
-
G
E
G-
R
--
G
-----
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
-
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
D
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
-------
A
G
A
M
A
N
P
M
F
A
L
K
G
G
-
L
I
R
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
A
L
G
D
-
R
-
V
G
--
Q
P
L
--
V
A
S
AA
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
R
---
30
PsiBlast_CBE
82.72
34%
-104
- C1 -
3PEF
1
?
F:
[3-286]
-----
K
F
G
F
I
G
L
G
I
M
G
S
A
M
A
K
N
L
V
K
A
G
C
S
V
T
I
W
N
R
S
P
E
K
A
E
E
L
A
A
L
G
A
E
R
A
A
T
P
C
E
V
V
E
S
C
P
V
T
F
A
M
L
A
D
-
P
A
A
A
E
E
V
C
--
F
G
K
HG
V
L
E
G
I
-
G
E
G-
R
--
G
-----
Y
V
D
M
S
T
V
D
P
A
T
S
Q
R
I
-
G
V
A
V
V
A
K
G
G
R
F
L
E
A
P
V
S
G
S
K
K
P
A
E
D
G
T
L
I
I
L
A
A
G
D
R
N
L
Y
D
E
A
M
P
G
F
E
K
M
G
K
K
I
I
H
L
G
D
V
G
K
G
A
E
M
K
L
V
V
N
M
V
M
G
G
M
M
A
C
F
C
E
G
L
A
L
G
E
K
A
G
L
A
T
D
A
I
L
D
V
I
G
-------
A
G
A
M
A
N
P
M
F
A
L
K
G
G
-
L
I
R
D
R
N
F
A
P
A
F
P
L
K
H
M
Q
K
D
L
R
L
A
V
-
A
L
G
D
-
R
-
V
G
--
Q
P
L
--
V
A
S
AA
A
N
E
L
F
K
G
A
R
A
A
G
F
G
D
E
D
F
S
A
I
F
K
T
Y
E
----
9
PsiBlast_PDB
82.56
32%
-107
- C1 -
2UYY
2
GLYR1_HUMAN
A:
[32-312]
-----
K
I
G
F
L
G
L
G
L
M
G
S
G
I
V
S
N
L
L
K
M
G
H
T
V
T
V
W
N
R
T
A
E
K
C
D
L
F
I
Q
E
G
A
R
L
G
R
T
P
A
E
V
V
S
T
C
D
I
T
F
A
C
V
S
D
P
K
A
A
K
D
L
V
L
--
G
P
S
--
G
V
L
Q
G
-
I
R
PG
K
--
C
-----
Y
V
D
M
S
T
V
D
A
D
T
V
T
E
L
-
A
Q
V
I
V
S
R
G
G
R
F
L
E
A
P
V
S
G
N
Q
Q
L
S
N
D
G
M
L
V
I
L
A
A
G
D
R
G
L
Y
E
D
C
S
S
C
F
Q
A
M
G
K
T
S
F
F
L
G
E
V
G
N
A
A
K
M
M
L
I
V
N
M
V
Q
G
S
F
M
A
T
I
A
E
G
L
T
L
A
Q
V
T
G
Q
S
Q
Q
T
L
L
D
I
L
N
-------
Q
G
Q
L
A
S
I
F
L
D
Q
K
C
Q
-
N
I
L
Q
G
N
F
K
P
D
F
Y
L
K
Y
I
Q
K
D
L
R
L
A
I
-
A
L
G
D
-
A
-
V
N
HP
T
P
M
--
A
A
A
--
A
N
E
V
Y
K
R
A
K
A
L
D
Q
S
D
N
D
M
S
A
V
Y
R
A
Y
I
H
---
37
PsiBlast_CBE
78.48
32%
-91
- C1 -
2I9P
1
3HIDH_HUMAN
B:
[23-317]
----
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
---
P
T
S
I
N
A
I
E
--
A
Y
S
--
G
A
N
G
I
-
L
K
--
K
--
V
KKGSL
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
-
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
MSSGRCW
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
-
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
-
T
-
S
-
T
K
--
S
P
I
--
L
L
G
SL
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
E
E
E
T
36
PsiBlast_CBE
78.00
32%
-88
- C1 -
2I9P
1
3HIDH_HUMAN
C:
[23-315]
----
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
---
P
T
S
I
N
A
I
E
--
A
Y
S
--
G
A
N
G
I
-
L
K
--
K
--
V
KKGSL
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
-
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
MSSGRCW
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
-
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
-
T
-
S
-
T
K
--
S
P
I
--
L
L
G
SL
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
E
---
35
PsiBlast_CBE
77.69
32%
-89
- C1 -
2I9P
1
3HIDH_HUMAN
D:
[23-315]
----
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
---
P
T
S
I
N
A
I
E
--
A
Y
S
--
G
A
N
G
I
-
L
K
--
K
--
V
KKGSL
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
-
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
MSSGRCW
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
-
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
-
T
-
S
-
T
K
--
S
P
I
--
L
L
G
SL
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
E
---
7
PsiBlast_PDB
77.56
32%
-89
- C1 -
2I9P
1
3HIDH_HUMAN
A:
[23-315]
----
M
P
V
G
F
I
G
L
G
N
M
G
N
P
M
A
K
N
L
M
K
H
G
Y
P
L
I
I
Y
D
V
F
P
D
A
C
K
E
F
Q
D
A
G
E
Q
V
V
S
S
P
A
D
V
A
E
K
A
D
R
I
I
T
M
L
---
P
T
S
I
N
A
I
E
--
A
Y
S
--
G
A
N
G
I
-
L
K
--
K
--
V
KKG
S
L
L
I
D
S
S
T
I
D
P
A
V
S
K
E
L
-
A
K
E
V
E
K
M
G
A
V
F
M
D
A
P
V
S
G
G
V
G
A
A
R
S
G
N
L
T
F
M
V
G
G
V
E
D
E
F
A
A
A
Q
E
L
L
G
C
M
G
S
N
V
V
Y
C
G
A
V
G
T
G
Q
A
A
K
I
C
N
N
M
L
L
A
I
S
M
I
G
T
A
E
A
M
N
L
G
I
R
L
G
L
D
P
K
L
L
A
K
I
L
N
M
S
SGRCW
S
S
D
T
Y
N
P
V
P
G
V
M
D
G
-
V
P
S
A
N
N
Y
Q
G
G
F
G
T
T
L
M
A
K
D
L
G
L
A
Q
D
S
A
-
T
-
S
-
T
K
--
S
P
I
--
L
L
G
S
L
A
H
Q
I
Y
R
M
M
C
A
K
G
Y
S
K
K
D
F
S
S
V
F
Q
F
L
R
E
---