@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0594: (2015-12-16 )
MRIEHDFIGQMEISDEVYYGIQTLRASENFFITNDKLCSYPVFIKSFAQVKKAAALANAQLGLIDEKLKIAICHACDLLVDGKYHDQFIVDMIQGGAGTSTNMNMNEVIANLALEYMGHQKGEYQFCHPNDHVNRSQSTNDAYPSALKIAIYERLSNLVAPMKALRDAFAQKAKEFAHVIKMGRTQLQDAVPMTLGQEFETYALMVDRDIEQVLDARNWVRELNLGGTVIGTGINSHPDYRSLIEKKIQEVTGRPFVMANNLIEATQSTGAYVQVSGVLKRIAVKLSKVCNDLRLLSSGPRAGLNEINLPKMQPGSSIMPGKVNPVIPEVVNQVCFAVIGNDLSVALAAEGGQLQLNVFEPVIAYKLFHSFVILGRAIETLTTKCVEGITANEKICHDYVFNSIGIVTALNPHIGYEKSAMIAKEALKSDRSIYDIALEKKILTKEQLDDIFKPENMLSPHAFKKHKD
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70........80........90........100.......110......--.120.......130.......140.......150...-....160........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370....-...-380.......390.......400.......410.......420.......430.......440.......450.......460......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRI
E
H
DFIG
Q
M
EIS
D
E
V
Y
Y
G
I
Q
T
LRASE
N
F
F
ITNDKLCS
Y
P
V
F
I
K
S
F
A
Q
V
K
K
A
A
A
L
ANAQLGLIDEK
L
K
I
A
I
C
H
A
C
D
L
LVDGK
Y
H
D
Q
F
I
V
D
M
IQGGAGTSTNM
N
M
N
E
V
I
A
N
L
A
L
E
Y
MG--HQKGE
Y
Q
F
CHPNDHVNRSQSTNDAY
P
S
A
L
K
I
A
I
Y
E
R
L
-
S
N
L
V
A
P
-
M
K
A
L
R
D
A
F
A
Q
K
A
K
E
F
A
H
V
I
K
M
G
R
T
Q
L
Q
DAVPMTLGQEF
E
T
Y
A
L
M
VD
R
D
I
E
Q
V
L
D
A
R
N
W
V
R
E
LNLG
G
T
V
I
GTGINSHP
D
Y
R
S
L
I
E
K
K
I
Q
E
VTGR
P
F
V
M
A
N
N
L
I
E
A
TQSTG
A
Y
V
Q
V
S
G
V
L
K
R
I
A
V
K
L
S
K
V
C
N
D
L
R
L
LSSGPRAGLNEINLPKMQPGSSIMPGKVNP
V
I
P
E
V
V
N
Q
V
C
F
A
V
IGND
L
S
V
A
L
AAEG
G
Q
L
Q
L
N
VF
E
P
V
I
A
Y
K
L
F
H
S
F
V
I
L
G
R
-
A
I
E
-
T
L
T
T
K
C
VEGITA
N
E
K
I
C
H
D
Y
V
F
NSI
G
I
V
T
ALNPHIGY
E
K
S
A
M
I
A
K
E
A
L
KSDR
S
I
Y
D
I
A
L
E
K
K
IL
T
K
E
Q
L
D
D
I
FKPENMLS
P
H
A
FKKHKD
24
PsiBlast_CBE
97.27
51%
-97
- C4 -
3R6V
1
?
F:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
-----
28
PsiBlast_CBE
96.97
51%
-95
- C4 -
3R6V
1
?
B:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
----
27
PsiBlast_CBE
96.46
51%
-97
- C4 -
3R6V
1
?
C:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
----
23
PsiBlast_CBE
96.27
51%
-94
- C4 -
3R6V
1
?
G:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
----
22
PsiBlast_CBE
96.21
51%
-96
- C4 -
3R6V
1
?
H:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
-------
26
PsiBlast_CBE
96.11
51%
-95
- C4 -
3R6V
2
?
D:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
-------
29
PsiBlast_CBE
95.78
51%
-98
- C4 -
3R6Q
1
?
H:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
----
3
PsiBlast_PDB
95.78
51%
-96
- C4 -
3R6Q
1
?
A:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
----
34
PsiBlast_CBE
95.21
51%
-88
- C4 -
3OCE
5
?
B:
[7-464]
-
R
R
E
Q
D
S
L
G
E
R
D
I
P
M
D
A
Y
F
G
I
Q
T
L
R
A
V
E
N
F
S
L
S
D
V
A
L
N
H
I
P
A
L
V
R
A
L
A
M
V
K
K
A
A
A
T
A
N
Y
K
L
R
Q
L
P
E
P
K
Y
A
A
I
V
A
A
C
D
D
I
I
D
G
L
L
M
E
Q
F
V
V
D
V
F
Q
G
G
A
G
T
S
S
N
M
N
A
N
E
V
I
A
N
R
A
L
E
H
L
G
--
R
P
R
G
D
Y
Q
T
I
H
P
N
D
D
V
N
M
S
Q
S
T
N
D
V
Y
P
T
A
V
R
L
A
L
L
L
S
Q
-
N
Q
V
Q
T
A
-
L
H
R
L
I
A
A
F
E
A
K
G
R
E
F
A
T
V
I
K
I
G
R
T
Q
L
Q
D
A
V
P
I
T
L
G
Q
E
F
E
A
F
A
A
T
L
R
E
D
T
A
R
L
E
E
V
A
A
L
F
R
E
V
N
L
G
G
T
A
I
G
T
R
I
N
A
S
H
A
Y
A
E
Q
A
I
V
E
L
S
Q
I
S
G
I
E
L
K
A
T
G
N
L
V
E
A
S
W
D
T
G
A
F
V
T
F
S
G
I
L
R
R
I
A
V
K
L
S
K
I
A
N
D
L
R
L
L
S
S
G
P
R
S
G
L
G
E
I
R
L
P
A
V
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
I
P
E
S
V
N
Q
V
C
Y
Q
V
I
G
N
D
L
T
V
T
M
A
A
E
S
G
Q
L
Q
L
N
A
F
E
P
L
I
V
Y
N
I
L
S
S
M
R
L
L
G
R
-
A
M
T
-
N
L
A
E
R
C
V
D
G
I
E
A
N
V
E
R
C
R
A
G
A
E
E
S
I
S
L
A
T
A
L
V
P
V
V
G
Y
A
R
A
A
E
I
A
K
Q
A
L
A
S
G
Q
T
V
M
E
V
A
I
S
K
G
-
L
D
A
S
A
L
T
I
M
L
D
P
L
R
M
A
F
P
P
-------
25
PsiBlast_CBE
94.90
51%
-94
- C4 -
3R6V
2
?
E:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
-------
30
PsiBlast_CBE
94.89
51%
-95
- C4 -
3R6Q
1
?
E:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
----
33
PsiBlast_CBE
94.66
51%
-91
- C4 -
3OCE
5
?
C:
[7-464]
-
R
R
E
Q
D
S
L
G
E
R
D
I
P
M
D
A
Y
F
G
I
Q
T
L
R
A
V
E
N
F
S
L
S
D
V
A
L
N
H
I
P
A
L
V
R
A
L
A
M
V
K
K
A
A
A
T
A
N
Y
K
L
R
Q
L
P
E
P
K
Y
A
A
I
V
A
A
C
D
D
I
I
D
G
L
L
M
E
Q
F
V
V
D
V
F
Q
G
G
A
G
T
S
S
N
M
N
A
N
E
V
I
A
N
R
A
L
E
H
L
G
--
R
P
R
G
D
Y
Q
T
I
H
P
N
D
D
V
N
M
S
Q
S
T
N
D
V
Y
P
T
A
V
R
L
A
L
L
L
S
Q
-
N
Q
V
Q
T
A
-
L
H
R
L
I
A
A
F
E
A
K
G
R
E
F
A
T
V
I
K
I
G
R
T
Q
L
Q
D
A
V
P
I
T
L
G
Q
E
F
E
A
F
A
A
T
L
R
E
D
T
A
R
L
E
E
V
A
A
L
F
R
E
V
N
L
G
G
T
A
I
G
T
R
I
N
A
S
H
A
Y
A
E
Q
A
I
V
E
L
S
Q
I
S
G
I
E
L
K
A
T
G
N
L
V
E
A
S
W
D
T
G
A
F
V
T
F
S
G
I
L
R
R
I
A
V
K
L
S
K
I
A
N
D
L
R
L
L
S
S
G
P
R
S
G
L
G
E
I
R
L
P
A
V
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
I
P
E
S
V
N
Q
V
C
Y
Q
V
I
G
N
D
L
T
V
T
M
A
A
E
S
G
Q
L
Q
L
N
A
F
E
P
L
I
V
Y
N
I
L
S
S
M
R
L
L
G
R
-
A
M
T
-
N
L
A
E
R
C
V
D
G
I
E
A
N
V
E
R
C
R
A
G
A
E
E
S
I
S
L
A
T
A
L
V
P
V
V
G
Y
A
R
A
A
E
I
A
K
Q
A
L
A
S
G
Q
T
V
M
E
V
A
I
S
K
G
-
L
D
A
S
A
L
T
I
M
L
D
P
L
R
M
A
F
P
--------
32
PsiBlast_CBE
94.54
51%
-85
- C4 -
3OCE
5
?
D:
[7-464]
-
R
R
E
Q
D
S
L
G
E
R
D
I
P
M
D
A
Y
F
G
I
Q
T
L
R
A
V
E
N
F
S
L
S
D
V
A
L
N
H
I
P
A
L
V
R
A
L
A
M
V
K
K
A
A
A
T
A
N
Y
K
L
R
Q
L
P
E
P
K
Y
A
A
I
V
A
A
C
D
D
I
I
D
G
L
L
M
E
Q
F
V
V
D
V
F
Q
G
G
A
G
T
S
S
N
M
N
A
N
E
V
I
A
N
R
A
L
E
H
L
G
--
R
P
R
G
D
Y
Q
T
I
H
P
N
D
D
V
N
M
S
Q
S
T
N
D
V
Y
P
T
A
V
R
L
A
L
L
L
S
Q
-
N
Q
V
Q
T
A
-
L
H
R
L
I
A
A
F
E
A
K
G
R
E
F
A
T
V
I
K
I
G
R
T
Q
L
Q
D
A
V
P
I
T
L
G
Q
E
F
E
A
F
A
A
T
L
R
E
D
T
A
R
L
E
E
V
A
A
L
F
R
E
V
N
L
G
G
T
A
I
G
T
R
I
N
A
S
H
A
Y
A
E
Q
A
I
V
E
L
S
Q
I
S
G
I
E
L
K
A
T
G
N
L
V
E
A
S
W
D
T
G
A
F
V
T
F
S
G
I
L
R
R
I
A
V
K
L
S
K
I
A
N
D
L
R
L
L
S
S
G
P
R
S
G
L
G
E
I
R
L
P
A
V
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
I
P
E
S
V
N
Q
V
C
Y
Q
V
I
G
N
D
L
T
V
T
M
A
A
E
S
G
Q
L
Q
L
N
A
F
E
P
L
I
V
Y
N
I
L
S
S
M
R
L
L
G
R
-
A
M
T
-
N
L
A
E
R
C
V
D
G
I
E
A
N
V
E
R
C
R
A
G
A
E
E
S
I
S
L
A
T
A
L
V
P
V
V
G
Y
A
R
A
A
E
I
A
K
Q
A
L
A
S
G
Q
T
V
M
E
V
A
I
S
K
G
-
L
D
A
S
A
L
T
I
M
L
D
P
L
R
M
A
F
P
--------
31
PsiBlast_CBE
94.50
51%
-96
- C4 -
3R6Q
2
?
D:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
----
2
PsiBlast_PDB
94.41
51%
-94
- C4 -
1J3U
-
?
A:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
----
76
HHSearch
94.12
51%
-91
- C4 -
3R6Q
1
?
A:
[5-466]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
--
I
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
EE
K
G
--
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
V
F
K
S
-
F
T
-
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
G
I
A
G
----
4
PsiBlast_PDB
93.95
51%
-96
- C4 -
3R6V
2
?
A:
[5-462]
V
R
I
E
K
D
F
L
G
E
K
E
I
P
K
D
A
Y
Y
G
V
Q
T
I
R
A
T
E
N
F
P
I
T
G
Y
R
I
--
H
P
E
L
I
K
S
L
G
I
V
K
K
S
A
A
L
A
N
M
E
V
G
L
L
D
K
E
V
G
Q
Y
I
V
K
A
A
D
E
V
I
E
G
K
W
N
D
Q
F
I
V
D
P
I
Q
G
G
A
G
T
S
I
N
M
N
A
N
E
V
I
A
N
R
A
L
E
L
M
G
--
E
E
K
G
N
Y
S
K
I
S
P
N
S
H
V
N
M
S
Q
S
T
N
D
A
F
P
T
A
T
H
I
A
V
L
S
L
L
-
N
Q
L
I
E
T
-
T
K
Y
M
Q
Q
E
F
M
K
K
A
D
E
F
A
G
V
I
K
M
G
R
T
H
L
Q
D
A
V
P
I
L
L
G
Q
E
F
E
A
Y
A
R
V
I
A
R
D
I
E
R
I
A
N
T
R
N
N
L
Y
D
I
N
M
G
A
T
A
V
G
T
G
L
N
A
D
P
E
Y
I
S
I
V
T
E
H
L
A
K
F
S
G
H
P
L
R
S
A
Q
H
L
V
D
A
T
Q
N
T
D
C
Y
T
E
V
S
S
A
L
K
V
C
M
I
N
M
S
K
I
A
N
D
L
R
L
M
A
S
G
P
R
A
G
L
S
E
I
V
L
P
A
R
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
M
P
E
V
M
N
Q
V
A
F
Q
V
F
G
N
D
L
T
I
T
S
A
S
E
A
G
Q
F
E
L
N
V
M
E
P
V
L
F
F
N
L
I
Q
S
I
S
I
M
T
N
-
V
F
K
-
S
F
T
E
N
C
L
K
G
I
K
A
N
E
E
R
M
K
E
Y
V
E
K
S
I
G
I
I
T
A
I
N
P
H
V
G
Y
E
T
A
A
K
L
A
R
E
A
Y
L
T
G
E
S
I
R
E
L
C
I
K
Y
G
V
L
T
E
E
Q
L
N
E
I
L
N
P
Y
E
M
I
H
P
--------
5
PsiBlast_PDB
92.90
51%
-91
- C4 -
3OCE
6
?
A:
[7-464]
-
R
R
E
Q
D
S
L
G
E
R
D
I
P
M
D
A
Y
F
G
I
Q
T
L
R
A
V
E
N
F
S
L
S
D
V
A
L
N
H
I
P
A
L
V
R
A
L
A
M
V
K
K
A
A
A
T
A
N
Y
K
L
R
Q
L
P
E
P
K
Y
A
A
I
V
A
A
C
D
D
I
I
D
G
L
L
M
E
Q
F
V
V
D
V
F
Q
G
G
A
G
T
S
S
N
M
N
A
N
E
V
I
A
N
R
A
L
E
H
L
G
--
R
P
R
G
D
Y
Q
T
I
H
P
N
D
D
V
N
M
S
Q
S
T
N
D
V
Y
P
T
A
V
R
L
A
L
L
L
S
Q
-
N
Q
V
Q
T
A
-
L
H
R
L
I
A
A
F
E
A
K
G
R
E
F
A
T
V
I
K
I
G
R
T
Q
L
Q
D
A
V
P
I
T
L
G
Q
E
F
E
A
F
A
A
T
L
R
E
D
T
A
R
L
E
E
V
A
A
L
F
R
E
V
N
L
G
G
T
A
I
G
T
R
I
N
A
S
H
A
Y
A
E
Q
A
I
V
E
L
S
Q
I
S
G
I
E
L
K
A
T
G
N
L
V
E
A
S
W
D
T
G
A
F
V
T
F
S
G
I
L
R
R
I
A
V
K
L
S
K
I
A
N
D
L
R
L
L
S
S
G
P
R
S
G
L
G
E
I
R
L
P
A
V
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
I
P
E
S
V
N
Q
V
C
Y
Q
V
I
G
N
D
L
T
V
T
M
A
A
E
S
G
Q
L
Q
L
N
A
F
E
P
L
I
V
Y
N
I
L
S
S
M
R
L
L
G
R
-
A
M
T
-
N
L
A
E
R
C
V
D
G
I
E
A
N
V
E
R
C
R
A
G
A
E
E
S
I
S
L
A
T
A
L
V
P
V
V
G
Y
A
R
A
A
E
I
A
K
Q
A
L
A
S
G
Q
T
V
M
E
V
A
I
S
K
G
-
L
D
A
S
A
L
T
I
M
L
D
P
L
R
M
A
F
P
P
-------
77
HHSearch
91.13
51%
-84
- C4 -
3OCF
3
?
A:
[23-477]
T
R
R
E
Q
D
S
L
G
E
R
D
I
P
M
D
A
Y
F
G
I
Q
T
L
R
A
V
E
N
F
S
L
S
D
V
A
L
N
H
I
P
A
L
V
R
A
L
A
M
V
K
K
A
A
A
T
A
N
Y
K
L
R
Q
L
P
E
P
K
Y
A
A
I
V
A
A
C
D
D
I
I
D
G
L
L
M
E
Q
F
V
V
D
V
F
Q
G
G
A
G
T
S
S
N
M
N
A
N
E
V
I
A
N
R
A
L
E
H
L
G
--
R
P
R
G
D
Y
Q
T
I
H
P
N
D
D
V
N
M
S
Q
S
T
N
D
V
Y
P
T
A
V
R
L
A
L
L
L
S
Q
-
N
Q
V
Q
T
A
-
L
H
R
L
I
A
A
F
E
A
K
G
R
E
F
A
T
V
I
K
I
G
R
T
Q
L
Q
D
A
V
P
I
T
L
G
Q
E
F
E
A
F
A
A
T
L
R
E
D
T
A
R
L
E
E
V
A
A
L
F
R
E
V
N
L
G
G
-----------
A
Y
A
E
Q
A
I
V
E
L
S
Q
I
S
G
I
E
L
K
A
T
G
N
L
V
E
A
S
W
D
T
G
A
F
V
T
F
S
G
I
L
R
R
I
A
V
K
L
S
K
I
A
N
D
L
R
L
L
S
S
G
P
R
S
G
L
G
E
I
R
L
P
A
V
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
I
P
E
S
V
N
Q
V
C
Y
Q
V
I
G
N
D
L
T
V
T
M
A
A
E
S
G
Q
L
Q
L
N
A
F
E
P
L
I
V
Y
N
I
L
S
S
M
R
L
L
G
R
-
A
M
T
N
L
A
-
E
R
C
V
D
G
I
E
A
N
V
E
R
C
R
A
G
A
E
E
S
I
S
L
A
T
A
L
V
P
V
V
G
Y
A
R
A
A
E
I
A
K
Q
A
L
A
S
G
Q
T
V
M
E
V
A
I
S
K
G
-
L
D
A
S
A
L
T
I
M
L
D
P
L
R
------------
36
PsiBlast_CBE
90.89
52%
-88
- C4 -
3OCF
3
?
B:
[24-461]
-
R
R
E
Q
D
S
L
G
E
R
D
I
P
M
D
A
Y
F
G
I
Q
T
L
R
A
V
E
N
F
S
L
S
D
V
A
L
N
H
I
P
A
L
V
R
A
L
A
M
V
K
K
A
A
A
T
A
N
Y
K
L
R
Q
L
P
E
P
K
Y
A
A
I
V
A
A
C
D
D
I
I
D
G
L
L
M
E
Q
F
V
V
D
V
F
Q
G
G
A
G
T
S
S
N
M
N
A
N
E
V
I
A
N
R
A
L
E
H
L
G
--
R
P
R
G
D
Y
Q
T
I
H
P
N
D
D
V
N
M
S
Q
S
T
N
D
V
Y
P
T
A
V
R
L
A
L
L
L
S
Q
-
N
Q
V
Q
T
A
-
L
H
R
L
I
A
A
F
E
A
K
G
R
E
F
A
T
V
I
K
I
G
R
T
Q
L
Q
D
A
V
P
I
T
L
G
Q
E
F
E
A
F
A
A
T
L
R
E
D
T
A
R
L
E
E
V
A
A
L
F
R
E
V
N
L
G
G
----------
H
A
Y
A
E
Q
A
I
V
E
L
S
Q
I
S
G
I
E
L
K
A
T
G
N
L
V
E
A
S
W
D
T
G
A
F
V
T
F
S
G
I
L
R
R
I
A
V
K
L
S
K
I
A
N
D
L
R
L
L
S
S
G
P
R
S
G
L
G
E
I
R
L
P
A
V
Q
P
G
S
S
I
M
P
G
K
V
N
P
V
I
P
E
S
V
N
Q
V
C
Y
Q
V
I
G
N
D
L
T
V
T
M
A
A
E
S
G
Q
L
Q
L
N
A
F
E
P
L
I
V
Y
N
I
L
S
S
M
R
L
L
G
R
-
A
M
T
-
N
L
A
E
R
C
V
D
G
I
E
A
N
V
E
R
C
R
A
G
A
E
E
S
I
S
L
A
T
A
L
V
P
V
V
G
Y
A
R
A
A
E
I
A
K
Q
A
L
A
S
G
Q
T
V
M
E
V
A
I
S
-----------------------------
45
PsiBlast_CBE
86.66
38%
-88
- C4 -
1FUQ
2
FUMC_ECOLI
B:
[4-459]
V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------
44
PsiBlast_CBE
86.53
39%
-87
- C4 -
1KQ7
1
FUMC_ECOLI
B:
[4-459]
V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
Q
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------
47
PsiBlast_CBE
86.42
39%
-88
- C4 -
1FUO
2
FUMC_ECOLI
B:
[4-459]
V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------
9
PsiBlast_PDB
86.25
41%
-87
- C4 -
3TV2
2
?
A:
[1-457]
-
R
M
E
R
D
T
F
G
E
I
A
V
P
A
A
R
L
W
G
A
Q
T
Q
R
S
L
Q
N
F
K
I
S
T
E
K
--
Q
S
P
E
L
I
H
A
L
A
L
I
K
R
A
A
A
A
V
N
L
E
L
G
V
L
A
Q
D
K
A
N
A
I
V
A
A
A
D
E
I
I
A
G
R
H
A
D
E
F
P
L
A
V
W
Q
T
G
S
G
T
Q
T
N
M
N
L
N
E
V
I
A
N
R
A
S
E
L
L
G
--
G
E
R
G
E
S
R
A
V
H
P
N
D
D
V
N
R
G
Q
S
S
N
D
V
F
P
T
A
M
H
I
A
A
A
R
A
I
V
D
H
L
L
P
A
-
L
R
T
L
R
A
T
L
D
A
K
A
A
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
F
S
G
Y
V
A
Q
L
D
Q
G
I
R
H
V
E
A
A
L
P
H
L
Y
E
L
A
Q
G
G
T
A
V
G
T
G
L
N
A
H
P
K
F
A
A
G
V
A
A
E
I
G
R
L
T
G
L
P
F
V
S
A
P
N
K
F
E
V
M
A
A
A
D
A
L
V
F
A
H
G
A
L
K
T
V
A
A
S
L
M
K
I
A
N
D
I
R
W
L
A
S
G
P
R
C
G
L
G
E
L
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
S
E
A
V
T
M
L
C
C
Q
V
F
G
N
D
V
A
V
N
F
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
I
A
H
N
V
L
Q
S
V
R
L
L
A
D
-
G
A
Q
-
G
F
N
D
H
C
A
V
G
I
E
P
N
R
A
R
I
D
A
L
L
N
E
S
L
M
L
V
T
A
L
N
P
H
I
G
Y
D
K
A
A
Q
I
A
K
K
A
H
K
E
G
T
T
L
K
A
A
A
L
A
L
G
Y
V
T
D
A
Q
F
D
E
W
V
R
P
E
H
M
V
G
---------
12
PsiBlast_PDB
85.94
39%
-84
- C4 -
1KQ7
2
FUMC_ECOLI
A:
[4-459]
V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
Q
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------
49
PsiBlast_CBE
85.67
39%
-87
- C4 -
2FUS
1
FUMC_ECOLI
B:
[4-459]
V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
N
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------
15
PsiBlast_PDB
85.67
39%
-86
- C4 -
1FUO
2
FUMC_ECOLI
A:
[4-459]
V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------
46
PsiBlast_CBE
85.20
38%
-86
- C4 -
1FUP
2
FUMC_ECOLI
B:
[4-459]
V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
----
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------
14
PsiBlast_PDB
84.75
38%
-86
- C4 -
1FUQ
2
FUMC_ECOLI
A:
[4-459]
V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------
13
PsiBlast_PDB
84.59
38%
-86
- C4 -
1FUP
2
FUMC_ECOLI
A:
[5-459]
-
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
H
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------
18
PsiBlast_PDB
83.43
39%
-86
- C4 -
2FUS
1
FUMC_ECOLI
A:
[4-459]
V
R
S
E
K
D
S
M
G
A
I
D
V
P
A
D
K
L
W
G
A
Q
T
Q
R
S
L
E
H
F
R
I
S
T
E
K
M
P
T
S
--
L
I
H
A
L
A
L
T
K
R
A
A
A
K
V
N
E
D
L
G
L
L
S
E
E
K
A
S
A
I
R
Q
A
A
D
E
V
L
A
G
Q
H
D
D
E
F
P
L
A
I
W
Q
T
G
S
G
T
Q
S
N
M
N
M
N
E
V
L
A
N
R
A
S
E
L
L
G
--
G
V
R
G
M
E
R
K
V
N
P
N
D
D
V
N
K
S
Q
S
S
N
D
V
F
P
T
A
M
H
V
A
A
L
L
A
L
-
R
K
Q
L
I
P
Q
L
K
T
L
T
Q
T
L
N
E
K
S
R
A
F
A
D
I
V
K
I
G
R
T
H
L
Q
D
A
T
P
L
T
L
G
Q
E
I
S
G
W
V
A
M
L
E
H
N
L
K
H
I
E
Y
S
L
P
H
V
A
E
L
A
L
G
G
T
A
V
G
T
G
L
N
T
H
P
E
Y
A
R
R
V
A
D
E
L
A
V
I
T
C
A
P
F
V
T
A
P
N
K
F
E
A
L
A
T
C
D
A
L
V
Q
A
H
G
A
L
K
G
L
A
A
S
L
M
K
I
A
N
D
V
R
W
L
A
S
G
P
R
C
G
I
G
E
I
S
I
P
E
N
E
P
G
S
S
I
M
P
G
K
V
N
P
T
Q
C
E
A
L
T
M
L
C
C
Q
V
M
G
N
D
V
A
I
N
M
G
G
A
S
G
N
F
E
L
N
V
F
R
P
M
V
I
H
N
F
L
Q
S
V
R
L
L
A
D
-
G
M
E
-
S
F
N
K
H
C
A
V
G
I
E
P
N
R
E
R
I
N
Q
L
L
N
E
S
L
M
L
V
T
A
L
N
T
H
I
G
Y
D
K
A
A
E
I
A
K
K
A
H
K
E
G
L
T
L
K
A
A
A
L
A
L
G
Y
L
S
E
A
E
F
D
S
W
V
R
P
E
Q
M
-----------