@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0608: (2015-12-16 )
MNTLGRFLRLTTFGESHGDMIGGVLDGMPSGIKIDYDLLENEMKRRQGGRNIFTTPRKEDDKVEITSGVFEGFSAGTPIGFLIHNQRARSKDYDNIKNLFRPSHADFTYFHKYGIRDFRGGGRSSARESAIRVAAGAFAKMLLREIGVVCESGIIKIGGIEAKNYDFNHALKSEIFALDKEQEEAQKTAIQNAIKNHDSIGGVALIRARGAKTNQKLPIGLGQGLYAKLDAKIAEAMMGLNGVKAVEIGKGVESSLLKGSEYNDLMSQKGFLSNHSGGVLGGMSNGEEIIVKVHFKPTPSIFQPQRTIDIKGNECECLLKGRHDPCIAIRGSVVCESLLSLVLADMVLLNLTSKIEYLKTIYNEN
Atome Classification :
(20 SA)
.........10........20........30........40.....-----...50........60........70........80..----....---------..---------90....--------.---------------...100-------.........110......-.120........130.......-140...-....150......------.160--...----.-----.-------.--------------..170.......180......--------------.190.......200.......210.......220...-.-.--..230.......240.......250.......260..--..--...-----270--.......280.......290.......300.......310.......320.......330.......340.......350.-......360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
T
L
G
R
F
L
R
L
T
TFGESH
G
D
M
I
G
G
V
L
DGMPSG
I
K
I
D
Y
D
L
L
E
N
E
M
K
R
R-----QGGRNIFTTPRKEDD
K
V
E
I
T
S
G
V
F
EGFSAGT
P
I
G
F
L
I
----HNQR---------AR---------SK
D
Y
D
N
--------
I
---------------
K
N
LF---------RPSHA
D
F
T
Y
F
H
KYGIRDF-RGG-GR
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
-
K
M
L
L
R
E
-
I
G
V
V
C
ESG
I
I
K
IG------
G
I
E
---AKN----Y-----D-------F--------------
N
H
A
L
K
S
E
I
F
ALD
K
E
Q
E
E
A
Q
K
T
--------------
A
I
Q
N
A
I
KNHDSIG
G
V
A
L
I
R
ARGAKTNQKLPIGLGQ
G
L
-
Y
-
A
--
K
L
D
A
K
I
A
E
A
M
MGLNG
V
K
A
V
EIGK
G
V
E
S
S
LLKGS
E
Y
N
D
--
L
M
--
S
QK-----GFL--SNHSGGVLGGMSNG
E
E
I
I
V
K
V
HFKPTPSIFQPQ
R
T
I
D
IKGNE
C
E
C
L
LKGRHD
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
S
L
V
L
A
D
M
V
L
L
N
L
T
S
-
K
I
E
Y
L
K
T
I
YNEN
2
PsiBlast_PDB
97.31
95%
-91
- C4 -
1UMF
-
AROC_HELPY
A:
[1-365]
M
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
----
H
N
Q
R
---------
A
R
---------
S
K
D
Y
D
N
--------
I
---------------
K
N
L
F
---------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
-
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
-
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
------
G
I
K
---
A
K
N
----
Y
-----
D
-------
F
--------------
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
--------------
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
K
T
N
Q
K
L
P
I
G
L
G
Q
G
L
-
Y
-
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
--
L
M
--
D
Q
K
-----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
-
K
I
E
Y
L
K
T
I
Y
N
E
N
18
HHSearch
97.26
95%
-93
- C4 -
1UM0
2
AROC_HELPY
A:
[1-365]
M
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
----
H
N
Q
R
---------
A
R
---------
S
K
D
Y
D
N
--------
I
---------------
K
N
L
F
---------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
-
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
-
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
------
G
I
K
---
A
K
N
----
Y
-----
D
-------
F
--------------
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
--------------
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
K
T
N
Q
K
L
P
I
G
L
G
Q
G
L
-
Y
-
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
--
L
M
--
D
Q
K
-----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
-
K
I
E
Y
L
K
T
I
Y
N
E
N
1
PsiBlast_PDB
97.26
95%
-93
- C4 -
1UM0
2
AROC_HELPY
A:
[1-365]
M
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
----
H
N
Q
R
---------
A
R
---------
S
K
D
Y
D
N
--------
I
---------------
K
N
L
F
---------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
-
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
-
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
------
G
I
K
---
A
K
N
----
Y
-----
D
-------
F
--------------
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
--------------
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
K
T
N
Q
K
L
P
I
G
L
G
Q
G
L
-
Y
-
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
--
L
M
--
D
Q
K
-----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
-
K
I
E
Y
L
K
T
I
Y
N
E
N
14
PsiBlast_CBE
96.73
95%
-90
- C4 -
1UM0
2
AROC_HELPY
D:
[1-365]
M
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
----
H
N
Q
R
---------
A
R
---------
S
K
D
Y
D
N
--------
I
---------------
K
N
L
F
---------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
-
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
-
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
------
G
I
K
---
A
K
N
----
Y
-----
D
-------
F
--------------
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
--------------
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
K
T
N
Q
K
L
P
I
G
L
G
Q
G
L
-
Y
-
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
--
L
M
--
D
Q
K
-----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
-
K
I
E
Y
L
K
T
I
Y
N
E
N
15
PsiBlast_CBE
96.43
95%
-96
- C4 -
1UM0
2
AROC_HELPY
C:
[1-365]
M
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
----
H
N
Q
R
---------
A
R
---------
S
K
D
Y
D
N
--------
I
---------------
K
N
L
F
---------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
-
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
-
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
------
G
I
K
---
A
K
N
----
Y
-----
D
-------
F
--------------
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
--------------
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
K
T
N
Q
K
L
P
I
G
L
G
Q
G
L
-
Y
-
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
--
L
M
--
D
Q
K
-----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
-
K
I
E
Y
L
K
T
I
Y
N
E
N
16
PsiBlast_CBE
96.37
95%
-93
- C4 -
1UM0
2
AROC_HELPY
B:
[1-365]
M
N
T
L
G
R
F
L
R
L
T
T
F
G
E
S
H
G
D
V
I
G
G
V
L
D
G
M
P
S
G
I
K
I
D
Y
A
L
L
E
N
E
M
K
R
R
-----
Q
G
G
R
N
V
F
I
T
P
R
K
E
D
D
K
V
E
I
T
S
G
V
F
E
D
F
S
T
G
T
P
I
G
F
L
I
----
H
N
Q
R
---------
A
R
---------
S
K
D
Y
D
N
--------
I
---------------
K
N
L
F
---------
R
P
S
H
A
D
F
T
Y
F
H
K
Y
G
I
R
D
F
-
R
G
G
-
G
R
S
S
A
R
E
S
A
I
R
V
A
A
G
A
F
A
-
K
M
L
L
R
E
-
I
G
I
V
C
E
S
G
I
I
E
I
G
------
G
I
K
---
A
K
N
----
Y
-----
D
-------
F
--------------
N
H
A
L
K
S
E
I
F
A
L
D
E
E
Q
E
E
A
Q
K
T
--------------
A
I
Q
N
A
I
K
N
H
D
S
I
G
G
V
A
L
I
R
A
R
S
I
K
T
N
Q
K
L
P
I
G
L
G
Q
G
L
-
Y
-
A
--
K
L
D
A
K
I
A
E
A
M
M
G
L
N
G
V
K
A
V
E
I
G
K
G
V
E
S
S
L
L
K
G
S
E
Y
N
D
--
L
M
--
D
Q
K
-----
G
F
L
--
S
N
R
S
G
G
V
L
G
G
M
S
N
G
E
E
I
I
V
R
V
H
F
K
P
T
P
S
I
F
Q
P
Q
R
T
I
D
I
N
G
N
E
C
E
C
L
L
K
G
R
H
D
P
C
I
A
I
R
G
S
V
V
C
E
S
L
L
A
L
V
L
A
D
M
V
L
L
N
L
T
S
-
K
I
E
Y
L
K
T
I
Y
N
E
N
20
HHSearch
83.17
55%
-101
- C4 -
1SQ1
2
AROC_CAMJE
A:
[1-359]
M
N
T
F
G
T
R
L
K
F
T
S
F
G
E
S
H
G
V
A
V
G
C
I
I
D
G
M
P
A
G
V
K
F
D
E
E
F
L
Q
N
E
L
D
K
R
-----
K
G
------------
D
K
A
Q
V
L
S
G
V
F
E
G
Y
T
T
G
H
P
I
A
I
V
V
----
F
--------------------------------------------------------------------------------------------
S
A
R
E
S
V
A
R
V
A
G
G
A
V
A
-
A
M
L
L
R
E
-
F
D
I
C
V
Q
S
G
V
F
G
V
G
------
T
F
V
---
S
N
L
KEEE
F
-----
D
-------
F
--------------
E
F
A
K
K
S
E
I
F
C
L
D
P
K
L
E
S
D
F
K
N
--------------
E
I
L
N
A
R
N
S
K
D
S
V
G
A
A
V
F
T
K
V
S
G
------
M
L
I
G
L
G
E
V
L
-
Y
-
D
--
K
L
D
S
K
L
A
H
A
L
M
G
I
N
A
V
K
A
V
E
I
G
E
G
I
N
A
S
K
M
R
G
S
C
N
N
D
--
A
L
--
K
D
G
-----
K
F
L
--
S
N
H
S
G
G
I
L
G
G
I
S
N
G
E
N
L
I
L
K
T
Y
F
K
P
T
P
---------------------
G
R
H
D
P
C
V
G
V
R
G
S
V
V
A
S
A
M
V
R
L
V
L
A
D
C
L
L
L
N
A
S
A
-
N
L
N
N
L
K
N
A
Y
G
--
3
PsiBlast_PDB
82.60
52%
-101
- C4 -
1SQ1
2
AROC_CAMJE
A:
[2-359]
-
N
T
F
G
T
R
L
K
F
T
S
F
G
E
S
H
G
V
A
V
G
C
I
I
D
G
M
P
A
G
V
K
F
D
E
E
F
L
Q
N
E
L
D
K
R
-----
K
G
------------
D
K
A
Q
V
L
S
G
V
F
E
G
Y
T
T
G
H
P
I
A
I
V
V
----
F
--------------------------------------------------------------------------------------------
S
A
R
E
S
V
A
R
V
A
G
G
A
V
A
-
A
M
L
L
R
E
-
F
D
I
C
V
Q
S
G
V
F
G
V
G
TFVS--
N
L
K
---
E
E
E
----
F
-----
D
-------
F
--------------
E
F
A
K
K
S
E
I
F
C
L
D
P
K
L
E
S
D
F
K
N
--------------
E
I
L
N
A
R
N
S
K
D
S
V
G
A
A
V
F
T
K
V
S
G
M
------
L
I
G
L
G
E
V
L
-
Y
-
D
--
K
L
D
S
K
L
A
H
A
L
M
G
I
N
A
V
K
A
V
E
I
G
E
G
I
N
A
S
K
M
R
G
S
C
N
N
D
--
A
L
--
K
D
G
-----
K
F
L
--
S
N
H
S
G
G
I
L
G
G
I
S
N
G
E
N
L
I
L
K
T
Y
F
K
P
T
P
---------------------
G
R
H
D
P
C
V
G
V
R
G
S
V
V
A
S
A
M
V
R
L
V
L
A
D
C
L
L
L
N
A
S
A
-
N
L
N
N
L
K
N
A
Y
G
--
6
PsiBlast_PDB
77.99
44%
-90
- C4 -
4OB9
-
?
A:
[4-345]
-
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
-----
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
----
R
N
T
D
---------
Q
K
------------------------------------------------------------------------
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
-
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
------
N
E
V
---
A
E
K
----
L
-----
D
-------
W
--------------
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
--------------
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
K
V
P
V
G
W
G
E
P
V
-
F
-
D
--
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
--
E
L
--
T
S
H
-----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
--------------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
-
N
A
D
V
V
P
P
F
A
P
I
E
4
PsiBlast_PDB
77.72
44%
-91
- C4 -
4LJ2
-
?
A:
[4-345]
-
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
-----
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
----
R
N
T
D
---------
Q
K
---------
S
K
--------------------------------------------------------
R
D
Y
-
R
G
G
-
G
R
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
-
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
------
N
E
V
---
A
E
K
----
L
-----
D
-------
W
--------------
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
--------------
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
K
V
P
V
G
W
G
E
P
V
-
F
-
D
--
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
--
E
L
--
T
S
H
-----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
A
S
I
T
-----------------
K
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
-
N
A
D
V
V
P
P
F
A
P
I
E
17
PsiBlast_CBE
77.27
44%
-101
- C4 -
4O90
2
?
B:
[4-345]
-
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
-----
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
----
R
N
T
D
---------
Q
------------------------------------------------------------------------------
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
-
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
------
N
E
V
---
A
E
K
----
L
-----
D
-------
W
--------------
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
--------------
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
K
V
P
V
G
W
G
E
P
V
-
F
-
D
--
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
--
E
L
--
T
S
H
-----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
----------------------
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
-
N
-----------
5
PsiBlast_PDB
76.24
44%
-93
- C4 -
4O90
1
?
A:
[4-345]
-
N
S
I
G
Q
L
F
R
V
T
T
C
G
E
S
H
G
V
G
L
M
A
I
V
D
G
V
P
P
G
L
A
L
T
E
E
D
L
Q
K
D
L
D
R
R
-----
K
P
G
T
S
K
F
A
T
Q
R
K
E
P
D
Q
V
E
I
I
S
G
V
F
E
G
K
T
T
G
T
P
I
G
L
L
I
----
R
N
T
D
---------
Q
------------------------------------------------------------------------------
S
S
A
R
E
T
A
M
R
V
A
A
G
A
I
A
-
K
K
Y
L
A
E
K
F
G
V
L
I
R
G
H
V
T
Q
I
G
------
N
E
V
---
A
E
K
----
L
-----
D
-------
W
--------------
N
E
V
P
N
N
P
F
F
C
G
D
V
D
A
V
P
R
F
E
A
--------------
L
V
T
S
L
R
E
Q
G
T
S
C
G
A
K
L
E
I
L
A
------
E
K
V
P
V
G
W
G
E
P
V
-
F
-
D
--
R
L
D
A
D
I
A
H
A
M
M
S
I
N
A
V
K
G
V
E
I
G
D
G
F
A
V
A
G
Q
F
G
H
E
T
R
D
--
E
L
--
T
S
H
-----
G
F
L
--
A
N
H
A
G
G
I
L
G
G
I
S
S
G
Q
T
I
R
V
A
I
A
L
K
P
T
----------------------
G
R
H
D
P
C
V
G
V
R
A
T
P
I
A
E
A
M
L
A
I
V
L
M
D
H
F
L
R
H
R
A
Q
-
N
-----------
19
HHSearch
75.58
39%
-94
- C4 -
1R53
-
AROC_YEAST
A:
[1-371]
M
S
T
F
G
K
L
F
R
V
T
T
Y
G
E
S
H
C
K
S
V
G
C
I
V
D
G
V
P
P
G
M
S
L
T
E
A
D
I
Q
P
Q
L
T
R
R
-----
R
P
------------
D
R
V
E
I
Q
S
G
T
E
F
G
K
T
L
G
T
P
I
A
M
M
I
----
K
N
---------------------------------------------------------------------------------------------
R
E
T
I
G
R
V
A
S
G
A
I
A
-
E
K
F
L
A
Q
N
S
N
V
E
I
V
A
F
V
T
Q
I
G
------
E
I
K
---
M
N
R
----
D
-----
S
-------
F
D
P
E
F
Q
H
L
L
N
TIT
R
E
K
V
D
S
M
G
P
I
R
C
P
D
A
S
V
A
G
L
M
V
K
--------------
E
I
E
K
Y
R
G
N
K
D
S
I
G
G
V
V
T
C
V
V
R
N
------
L
P
T
G
L
G
E
P
C
-
F
-
D
--
K
L
E
A
M
L
A
H
A
M
L
S
I
P
A
S
K
G
F
E
I
G
S
G
F
Q
G
V
S
V
P
G
S
K
H
N
D
--
P
F
--
Y
-------
R
T
K
--
T
N
N
S
G
G
V
Q
G
G
I
S
N
G
E
N
I
Y
F
S
V
P
F
K
S
V
-----------------------
R
H
D
P
A
V
T
P
R
A
I
P
I
V
E
A
M
T
A
L
V
L
A
D
A
L
L
I
Q
K
A
R
-
D
F
S
---------
7
PsiBlast_PDB
75.19
36%
-89
- C4 -
1R53
-
AROC_YEAST
A:
[1-365]
M
S
T
F
G
K
L
F
R
V
T
T
Y
G
E
S
H
C
K
S
V
G
C
I
V
D
G
V
P
P
G
M
S
L
T
E
A
D
I
Q
P
Q
L
T
R
R
-----
R
P
------------
D
R
V
E
I
Q
S
G
T
E
F
G
K
T
L
G
T
P
I
A
M
M
I
----
K
N
---------------------------------------------------------------------------------------------
R
E
T
I
G
R
V
A
S
G
A
I
A
E
K
F
L
A
Q
N
-
S
N
V
E
I
V
A
F
V
T
Q
I
G
------
E
I
K
---
M
N
R
----
D
-----
S
-------
F
--------------
D
P
E
F
Q
H
L
L
N
T
I
T
R
E
K
V
D
S
M
G
P
IRCPDASV
A
G
L
M
V
K
E
I
E
K
Y
R
G
N
K
D
S
I
G
G
V
V
T
C
V
V
R
------
N
L
P
T
G
L
G
E
P
C
-
F
-
D
--
K
L
E
A
M
L
A
H
A
M
L
S
I
P
A
S
K
G
F
E
I
G
S
G
F
Q
G
V
S
V
P
G
S
K
H
N
D
--
P
F
Y---------
R
T
K
--
T
N
N
S
G
G
V
Q
G
G
I
S
N
G
E
N
I
Y
F
S
V
P
F
K
S
V
-----------------------
R
H
D
P
A
V
T
P
R
A
I
P
I
V
E
A
M
T
A
L
V
L
A
D
A
L
L
I
Q
K
A
R
-
D
F
S
---------
11
PsiBlast_PDB
74.96
32%
-86
- C4 -
2O12
6
AROC_MYCTU
A:
[1-367]
------
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
LGYG
R
-----------
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
----
G
N
T
E
WPKWETVMA
A
D
---------
P
V
D
P
A
E
--------
L
---------------
A
D
V
A
RNAPLTRP-
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
-
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
-
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
ASAPYE
G
P
P
---
P
R
A
----
E
-----
D
-------
L
--------------
P
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
--------------
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
V
A
L
G
------
L
P
V
G
L
G
S
F
T
-
S
-
G
DH
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
--
E
M
Y
P
G
P
D
-----
G
V
V
RS
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
-
D
S
L
A
E
T
Q
R
N
I
A
A
10
PsiBlast_PDB
74.33
32%
-86
- C4 -
2O11
6
AROC_MYCTU
A:
[1-367]
------
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
LGYG--------------
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
----
G
N
T
E
WPKWETVMA
A
D
---------
P
V
D
P
A
E
--------
L
---------------
A
D
V
A
RNAPLTRP-
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
-
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
-
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
ASAPYE
G
P
P
---
P
R
A
----
E
-----
D
-------
L
--------------
P
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
--------------
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
V
A
L
G
------
L
P
V
G
L
G
S
F
T
-
S
-
G
DH
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
--
E
M
Y
P
G
P
D
-----
G
V
V
RS
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
-
D
S
L
A
E
T
Q
R
N
I
A
A
22
HHSearch
73.85
33%
-76
- C4 -
1QXO
8
AROC_STRPN
A:
[1-377]
-------
M
R
Y
L
T
A
G
E
S
H
G
P
R
L
T
A
I
I
E
G
I
P
A
G
L
P
L
T
A
E
D
I
N
E
D
L
R
R
R
-----
Q
G
G
Y
G
R
G
G
R
M
K
I
E
N
D
Q
V
V
F
T
S
G
V
R
H
G
K
T
T
G
A
P
I
T
M
D
V
----
I
N
K
D
---------
H
Q
-----------
K
W
L
D
--------
I
MSAEDIEDRLKSKRK
I
T
H
P
---------
R
P
G
H
A
D
L
V
G
G
I
K
Y
R
F
D
D
L
R
N
S
L
-
E
R
S
S
A
R
E
T
T
M
R
V
A
V
G
A
V
A
-
K
R
L
L
A
E
-
L
D
M
E
I
A
N
H
V
V
V
F
G
------
G
K
E
---
I
D
V
----
P
-----
E
NLT
V
A
E
I
K
--------------
Q
R
A
A
Q
S
E
V
S
I
V
N
Q
E
R
E
Q
E
I
K
D
--------------
Y
I
D
Q
I
K
R
D
G
D
T
I
G
G
V
V
E
T
V
V
G
G
------
V
P
V
G
L
G
S
Y
V
Q
W
-
D
R-
K
L
D
A
R
L
A
Q
A
V
V
S
I
N
A
F
K
G
V
E
F
G
L
G
F
E
A
G
Y
R
K
G
S
Q
V
M
D
--
E
I
--
L
W
S
KEDGY
T
R
R
--
T
N
N
L
G
G
F
E
G
G
M
T
N
G
Q
P
I
V
V
R
G
V
M
K
P
I
P
T
L
Y
K
P
L
M
S
V
D
I
E
T
H
E
P
Y
K
A
T
V
E
R
S
D
P
T
A
L
P
A
A
G
M
V
M
E
A
V
V
A
T
V
L
A
Q
E
I
L
E
K
F
S
S
-
D
N
L
E
E
L
K
E
A
V
A
K
23
HHSearch
73.48
33%
-75
- C4 -
2O11
7
AROC_MYCTU
A:
[1-383]
------
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
-----
R
L
G
Y
G
---------
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
----
G
N
T
E
---------
W
P
KWETVMAAD
P
V
D
P
A
E
L
A
D
VARNA
P
---------------
L
T
R
P
---------
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
R
P
V
L
-
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
-
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
------
A
S
A
---
P
Y
E
G
---
P
P
P
R
AE
D
-------
L
--------------
P
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
--------------
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
V
A
L
G
------
L
P
V
G
L
G
S
F
T
S
G
D
H
--
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
--
E
M
--
Y
P
G
PDGV-
V
R
S
--
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
-
D
S
L
A
E
T
Q
R
N
I
A
A
13
PsiBlast_PDB
73.45
31%
-75
- C4 -
1QXO
8
AROC_STRPN
A:
[2-375]
--------
R
Y
L
T
A
G
E
S
H
G
P
R
L
T
A
I
I
E
G
I
P
A
G
L
P
L
T
A
E
D
I
N
E
D
L
R
R
R
-----
Q
G
G
Y
G
R
G
G
R
M
K
I
E
N
D
Q
V
V
F
T
S
G
V
R
H
G
K
T
T
G
A
P
I
T
M
D
V
I
N
KD
H
Q
K
W
---------
L
D
---------
I
M
S
A
E
D
--------
I
---------------
E
D
R
L
KSKRKITHP
R
P
G
H
A
D
L
V
G
G
I
K
Y
R
F
D
D
L
-
R
N
S
L
E
R
S
S
A
R
E
T
T
M
R
V
A
V
G
A
V
A
-
K
R
L
L
A
E
-
L
D
M
E
I
A
N
H
V
V
V
F
G
------
G
K
E
I
D
V
P
E
N
----
L
-----
T
-------
V
A
E
I
K
----------
Q
R
A
A
Q
S
E
V
S
I
V
N
Q
E
R
E
Q
E
I
K
D
--------------
Y
I
D
Q
I
K
R
D
G
D
T
I
G
G
V
V
E
T
V
V
G
G
V
P
V
G
L
G
S
Y
V
Q
W
D
R
--------
K
L
D
A
R
L
A
Q
A
V
V
S
I
N
A
F
K
G
V
E
F
G
L
G
F
E
A
G
Y
R
K
G
S
Q
V
M
D
E
I
L
W
--
S
K
E
D----
G
Y
T
RR
T
N
N
L
G
G
F
E
G
G
M
T
N
G
Q
P
I
V
V
R
G
V
M
K
P
I
P
T
L
Y
K
P
L
M
S
V
D
I
E
T
H
E
P
Y
K
A
T
V
E
R
S
D
P
T
A
L
P
A
A
G
M
V
M
E
A
V
V
A
T
V
L
A
Q
E
I
L
E
K
F
S
S
D
N
L
E
E
L
K
E
A
V
A
K
H
9
PsiBlast_PDB
72.81
32%
-87
- C4 -
2G85
-
AROC_MYCTU
A:
[1-367]
------
M
L
R
W
I
T
A
G
E
S
H
G
R
A
L
V
A
V
V
E
G
M
V
A
G
V
H
V
T
S
A
D
I
A
D
Q
L
A
R
R
R
LGYG------
F
-----
E
R
D
A
V
T
V
L
S
G
I
R
H
G
S
T
L
G
G
P
I
A
I
E
I
----
G
N
T
E
WPKWETVMA
A
D
---------
P
V
D
P
A
E
--------
L
---------------
A
D
V
A
RNAPLTRP-
R
P
G
H
A
D
Y
A
G
M
L
K
Y
G
F
D
D
A
-
R
P
V
L
E
R
A
S
A
R
E
T
A
A
R
V
A
A
G
T
V
A
-
R
A
F
L
R
Q
A
L
G
V
E
V
L
S
H
V
I
S
I
G
ASA
P
Y
E
G
P
P
---
P
R
A
----
E
-----
D
-------
L
--------------
P
A
I
D
A
S
P
V
R
A
Y
D
K
A
A
E
A
D
M
I
A
--------------
Q
I
E
A
A
K
K
D
G
D
T
L
G
G
V
V
E
A
V
A
L
G
------
L
P
V
G
L
G
S
F
T
-
S
-
G
DH
R
L
D
S
Q
L
A
A
A
V
M
G
I
Q
A
I
K
G
V
E
I
G
D
G
F
Q
T
A
R
R
R
G
S
R
A
H
D
--
E
M
Y
P
G
P
D
-----
G
V
V
RS
T
N
R
A
G
G
L
E
G
G
M
T
N
G
Q
P
L
R
V
R
A
A
M
K
P
I
S
T
V
P
R
A
L
A
T
V
D
L
A
T
G
D
E
A
V
A
I
H
Q
R
S
D
V
C
A
V
P
A
A
G
V
V
V
E
T
M
V
A
L
V
L
A
R
A
A
L
E
K
F
G
G
-
D
S
L
A
E
T
Q
R
N
I
A
A