@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0627: (2015-12-17 )
MKEIIVALVGQPNVGKSSLINALSNAHLKVGNFAGVTVDKMEVSLIHKDHQITIIDLPGTYALNDFTTEEKVTKDFLEKGQYDLILNVVDSTNLERNLALSAQLLDTNKKMLLALNMWDEAKKEGININTEKLSQELGVVCVPTSARSKEDRLNTELLLDEIVRLYSQNTTNNENIKVPSQSFKESLKYSQSAQRIAKSVISENKQNASFEHTYKIDKILMHQRYGIFIFLGFMFIIFSLSFLIGGGVQKALEEGFKILSDSIKENVANEDLASLVGDGIIGGVGATVSFLPLIVVLYFGISLLETTGYMSRVAFLLDGILHKFGLHGKSFIPLITGFGCSVPAYMATRTLQNYNERLITLFVIGFMSCSARLPIYVLFVGSFFPSSSAGFVLFCIYILGAVVALVMAKLLKLSVFKGQTESFIMEMPKYRFPSWRMVYFSIYTKSLSYLKKAGTYILVGAILIWFMSQYPKNDAAMKTYKQESLLVQKNANLSSEAKEEKLKELKTELDKKNLKNSVVGRGGAYLEKVFNPMDFDWRLSVSLVTGFMAKEVVVSTLGVLFSLGDQNEKSDAFREIIRKEVSVPSGIAFIVFVMFYIPCFAATITFGREAGGIKFVAYLFIFTTVVAYAFSLIAFYATQILV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.....----..---.70........80........90.......-.100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.-......210.......220......----.230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
E
I
I
V
A
L
VGQPNV
G
K
S
S
L
I
N
A
L
SNA
H
L
K
VGNFA
G
V
T
V
D
K
M
E
V
S
L
I
HKD
H
Q
I
T
I
I
DLPGTYALNDF----T
T
---
E
E
K
V
T
K
D
F
L
EKGQ
Y
D
L
I
L
N
VVDSTNLERNL-
A
L
S
A
Q
LLDTN
K
K
M
L
L
A
LNM
W
D
E
A
K
KEGINI
N
T
E
K
L
S
Q
EL
G
V
V
C
VPTSARS
K
E
DRL
N
T
E
L
L
L
D
E
I
V
R
L
YSQNTTNNE
N
I
KV
P
S
Q
S
F
K
E
S
L
K
Y
S
Q
S
A
Q
R
I
A
K
S
V
I
S
E-NKQNASFE
H
T
Y
K
I
D
K
I
L
M
H
QRY
G
I
F
----
I
F
L
G
F
M
F
I
I
F
S
L
S
F
L
IGG
G
V
Q
K
A
L
E
E
G
F
K
I
L
S
D
S
I
K
E
N
VA
N
E
D
L
A
S
L
V
GDGIIGG
V
G
A
T
V
S
F
L
P
L
I
V
V
L
Y
F
G
I
S
L
L
E
TT
G
Y
M
S
R
V
A
F
L
L
D
G
I
L
H
K
FGLHGK
S
F
I
P
L
I
TGFGCS
V
P
A
Y
M
A
T
R
T
L
Q
N
Y
N
E
R
L
I
T
L
F
V
I
G
F
M
SCSAR
L
P
I
Y
V
L
F
V
GSFFPSSSA
G
F
V
L
F
C
I
Y
I
L
G
A
V
V
A
L
V
M
A
K
L
L
K
L
S
VFKG
Q
T
E
S
F
I
M
EMPKYRFPS
W
R
M
V
Y
F
S
I
Y
T
K
S
L
S
Y
L
K
KAGT
Y
I
L
V
G
A
I
L
I
W
F
M
S
QYPK
N
D
A
A
M
K
T
Y
K
QE
S
L
L
V
QKNANLS
S
E
A
K
E
E
K
L
K
E
L
K
T
E
L
D
K
K
N
L
K
N
S
VVGR
G
G
A
Y
L
E
K
VFNPMDF
D
W
R
L
S
V
S
L
V
T
G
F
M
A
K
E
V
V
V
S
T
L
G
V
L
F
SLGDQNE
K
S
D
A
F
R
E
I
I
R
K
EVSVP
S
G
I
A
F
I
V
F
V
M
F
Y
I
P
C
F
A
A
T
I
TFGREAG
G
I
K
F
V
A
Y
L
F
I
F
T
T
V
V
A
Y
A
F
S
L
I
A
F
Y
A
T
Q
ILV
96
Fugue
92.77
29%
-71
- C7 -
3I8S
-
FEOB_ECOLI
B:
[1-261]
M
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
Q
F
S
T
T
D
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
T
I
SSQT
S
L
---
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
-
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
---
R
G
I
E
A
L
K
L
A
I
D
-------------
R
Y
K
A
N
E
N
V
E
L
V
H
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
G
L
Q
M
L
E
G
D
I
Y
S
R
A
Y
A
GE
A
S
Q
H
L
D
A
A
L
A
R
L
R
N
E
M
D
D
P
A
L
H
I
A
D
A
R
Y
Q
C
I
A
A
I
C
D
V
V
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
HHSearch
84.15
43%
-83
* C7 *
3A1S
3
?
A:
[4-168]
-
H
M
V
K
V
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
W
P
G
V
T
V
E
K
K
E
G
V
F
T
Y
K
G
Y
T
I
N
L
I
D
L
P
G
T
Y
S
L
G
Y
S
----
S
I
---
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
D
L
V
I
L
V
A
D
S
V
N
P
E
Q
S
L
-
Y
L
L
L
E
I
L
E
M
E
K
K
V
I
L
A
M
T
A
I
D
E
A
K
K
T
G
M
K
I
D
R
Y
E
L
Q
K
H
L
G
I
P
V
V
F
T
S
S
V
T
G
E
G
---
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
T
I
L
H
R
M
I
L
D
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
D
K
K
L
R
I
N
P
-
R
Y
F
A
L
K
Y
L
S
G
D
P
E
F
Y
S
E
G
V
K
L
G
L
P
E
----
L
S
E
E
E
R
I
G
Y
R
L
L
I
A
K
R
K
R
E
Y
V
E
N
V
V
K
E
A
F
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
83.94
41%
-80
- C7 -
2WJG
1
FEOB_METJA
A:
[6-170]
-
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
N
W
P
G
V
T
V
E
K
K
E
G
E
F
E
Y
N
G
E
K
F
K
V
V
D
L
P
G
V
Y
S
L
T
A
N
----
S
I
---
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
-
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
---
I
E
E
L
K
K
A
I
S
I
A
V
K
D
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.42
42%
-66
- C7 -
3LX8
1
?
A:
[6-164]
-----
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
-
K
S
G
L
V
K
K
N
K
D
L
E
I
Q
D
L
P
G
I
Y
S
M
S
P
Y
----
S
P
---
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
-
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
-------
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
D
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
-
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
----
F
Q
R
K
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
82.34
43%
-78
- C7 -
3A1W
1
?
A:
[8-166]
-----
V
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
W
P
G
V
T
V
E
K
K
E
G
V
F
T
Y
K
G
Y
T
I
N
L
I
D
L
P
G
T
Y
S
L
G
Y
S
----
S
I
---
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
D
L
V
I
L
V
A
D
S
V
N
P
E
Q
S
L
-
Y
L
L
L
E
I
L
E
M
E
K
K
V
I
L
A
M
T
A
I
D
E
A
K
K
----
I
D
R
Y
E
L
Q
K
H
L
G
I
P
V
V
F
T
S
S
V
T
G
E
---
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
81.39
38%
-82
- C7 -
3K53
-
?
A:
[1-167]
M
V
L
K
T
V
A
L
V
G
N
P
N
V
G
K
T
T
I
F
N
A
L
T
G
L
R
Q
H
V
G
N
W
P
G
V
T
V
E
K
K
E
G
I
M
E
Y
R
E
K
E
F
L
V
V
D
L
P
G
I
Y
S
L
T
A
H
----
S
I
---
D
E
L
I
A
R
N
F
I
L
D
G
N
A
D
V
I
V
D
I
V
D
S
T
C
L
M
R
N
L
F
L
T
L
E
L
F
E
M
E
V
K
N
I
I
L
V
L
N
K
F
D
L
L
K
K
K
G
A
K
I
D
I
K
K
M
R
K
E
L
G
V
P
V
I
P
T
N
A
K
K
G
E
G
---
V
E
E
L
K
R
M
I
A
L
M
A
E
G
K
V
T
T
N
P
I
I
P
R
Y
D
E
D
I
E
R
E
I
K
H
I
S
E
L
L
R
G
T
P
L
A
E
K
Y
-
P
I
R
W
L
A
L
K
L
L
Q
R
D
E
E
V
I
K
L
V
L
K
Y
L
G
----
Q
E
K
M
D
E
I
L
K
H
I
S
E
L
E
E
K
Y
K
R
P
L
D
I
V
I
A
S
Q
K
Y
E
F
L
E
Q
L
L
R
K
F
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
81.08
41%
-66
- C7 -
3TAH
3
?
B:
[6-164]
-----
I
A
L
I
G
N
P
A
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
-
K
S
G
L
V
K
K
N
K
D
L
E
I
Q
D
L
P
G
I
Y
S
M
S
P
Y
----
S
P
---
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
-
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
-------
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
D
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
-
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
----
F
Q
R
K
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
S
H
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
81.00
41%
-66
- C7 -
3TAH
3
?
A:
[6-164]
-----
I
A
L
I
G
N
P
A
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
-
K
S
G
L
V
K
K
N
K
D
L
E
I
Q
D
L
P
G
I
Y
S
M
S
P
Y
----
S
P
---
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
-
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
-------
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
D
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
-
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
----
F
Q
R
K
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
80.84
41%
-88
- C7 -
2WJI
3
FEOB_METJA
A:
[2-163]
-
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
-----
T
V
E
K
K
E
G
E
F
E
Y
N
G
E
K
F
K
V
V
D
L
P
G
V
Y
S
L
T
A
N
----
S
I
---
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
-
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
---
I
E
E
L
K
K
A
I
S
I
A
V
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
80.73
43%
-77
- C7 -
3A1V
1
?
B:
[8-169]
-----
V
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
W
P
G
V
T
V
E
K
K
E
-
V
F
T
Y
K
G
Y
T
I
N
L
I
D
L
P
G
T
Y
S
L
G
Y
S
----
S
I
---
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
D
L
V
I
L
V
A
D
S
V
N
P
E
Q
S
L
-
Y
L
L
L
E
I
L
E
M
E
K
K
V
I
L
A
M
T
-----
K
K
T
G
M
K
I
D
R
Y
E
L
Q
K
H
L
G
I
P
V
V
F
T
S
S
V
T
G
E
---
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
T
I
L
H
R
M
I
L
D
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
D
K
K
L
R
I
N
P
-
R
Y
F
A
L
K
Y
L
S
G
D
P
E
F
Y
S
E
G
V
K
L
G
L
P
E
----
L
S
E
E
E
R
I
G
Y
R
L
L
I
A
K
R
K
R
E
Y
V
E
N
V
V
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.51
43%
-83
- C7 -
3A1T
1
?
A:
[8-169]
-----
V
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
W
P
G
V
T
V
E
K
K
E
G
V
F
T
Y
K
G
Y
T
I
N
L
I
D
L
P
G
T
Y
S
L
G
Y
S
----
S
I
---
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
D
L
V
I
L
V
A
D
S
V
N
P
E
Q
S
L
-
Y
L
L
L
E
I
L
E
M
E
K
K
V
I
L
A
M
T
A
I
D
E
A
K
K
T
G
M
K
I
D
R
Y
E
L
Q
K
H
L
G
I
P
V
V
F
T
S
S
V
T
G
E
---
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
T
I
L
H
R
M
I
L
D
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
D
K
K
L
R
I
N
P
-
R
Y
F
A
L
K
Y
L
S
G
D
P
E
F
Y
S
E
G
V
K
L
G
L
P
E
----
L
S
E
E
E
R
I
G
Y
R
L
L
I
A
K
R
K
R
E
Y
V
E
N
V
V
K
E
A
F
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
80.48
39%
-90
- C7 -
4R98
1
FEOB_ECOLI
B:
[2-175]
-
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
Q
F
S
T
T
D
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
T
I
----
S
-TS
L
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
-
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
A
---
T
D
T
K
N
V
Q
F
V
L
K
L
A
I
D
R
Y
K
A
----
N
E
N
V
E
L
V
H
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
-
Q
R
R
W
L
G
L
Q
M
L
E
G
D
I
Y
S
R
A
Y
A
G
E
A
S
Q
----
H
L
D
A
A
L
A
R
L
R
N
E
M
D
D
P
A
L
H
I
A
D
A
R
Y
Q
C
I
A
A
I
C
D
V
V
S
N
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
80.46
43%
-82
- C7 -
3A1V
2
?
A:
[8-169]
-----
V
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
W
P
G
V
T
V
E
K
K
E
G
V
F
T
Y
K
G
Y
T
I
N
L
I
D
L
P
G
T
Y
S
L
G
Y
S
----
S
I
---
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
D
L
V
I
L
V
A
D
S
V
N
P
E
Q
S
L
-
Y
L
L
L
E
I
L
E
M
E
K
K
V
I
L
A
M
T
A
I
D
E
A
K
K
T
G
M
K
I
D
R
Y
E
L
Q
K
H
L
G
I
P
V
V
F
T
S
S
V
T
G
E
---
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
T
H
R
M
I
L
D
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
D
K
K
L
R
I
N
P
R
Y
-
F
A
L
K
Y
L
S
G
D
P
E
F
Y
S
E
G
V
K
L
G
L
P
E
L
S
----
E
E
E
R
I
G
Y
R
L
L
I
A
K
R
K
R
E
Y
V
E
N
V
V
K
E
A
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
80.26
40%
-83
- C7 -
3I8S
-
FEOB_ECOLI
A:
[1-170]
M
K
K
L
T
I
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
S
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
Q
F
S
T
T
D
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
T
-T---
S
L
---
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
L
L
I
N
V
V
D
A
S
N
L
E
R
N
L
-
Y
L
T
L
Q
L
L
E
L
G
I
P
C
I
V
A
L
N
M
L
D
I
A
E
K
Q
N
I
R
I
E
I
D
A
L
S
A
R
L
G
C
P
V
I
P
L
V
S
T
R
G
R
G
---
I
E
A
L
K
L
A
I
D
R
Y
K
A
N
E
N
V
E
L
V
H
Y
A
Q
P
L
L
N
E
A
D
S
L
A
K
V
M
P
S
D
I
P
L
K
Q
R
R
W
L
-
G
L
Q
M
L
E
G
D
I
Y
S
R
A
Y
A
G
E
A
S
Q
H
L
D
A
A
----
L
A
R
L
R
N
E
M
D
D
P
A
L
H
I
A
D
A
R
Y
Q
C
I
A
A
I
C
D
V
V
S
N
T
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
80.26
43%
-78
- C7 -
3A1U
5
?
A:
[8-169]
-----
V
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
V
A
N
W
P
G
V
T
V
E
K
K
E
G
V
F
T
Y
K
G
Y
T
I
N
L
I
D
L
P
G
T
Y
S
L
G
Y
S
----
S
I
---
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
D
L
V
I
L
V
A
D
S
V
N
P
E
Q
S
L
-
Y
L
L
L
E
I
L
E
M
E
K
K
V
I
L
A
M
T
A
I
D
E
A
K
K
T
G
M
K
I
D
R
Y
E
L
Q
K
H
L
G
I
P
V
V
F
T
S
S
V
T
G
E
---
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
T
I
R
M
I
L
D
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
D
K
K
L
R
I
N
P
R
Y
-
F
A
L
K
Y
L
S
G
D
P
E
F
Y
S
E
G
V
K
L
G
L
P
E
L
S
----
E
E
E
R
I
G
Y
R
L
L
I
A
K
R
K
R
E
Y
V
E
N
V
V
K
E
A
F
A
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
80.19
41%
-94
- C7 -
2WIA
1
?
B:
[1-147]
M
Q
K
L
T
V
G
L
I
G
N
P
N
S
G
K
T
T
L
F
N
Q
L
T
G
A
R
Q
R
V
G
N
W
A
G
V
T
V
E
R
K
E
G
I
F
A
T
T
D
H
Q
V
T
L
V
D
L
P
G
T
Y
S
L
T
--------TS
L
D
E
Q
I
A
C
H
Y
I
L
S
G
D
A
D
M
L
I
N
V
V
D
A
S
N
L
E
R
N
L
-
Y
L
T
L
Q
L
L
E
L
G
I
P
C
V
V
A
L
N
M
L
D
I
A
E
K
Q
Q
V
R
I
D
I
D
A
L
A
A
R
L
G
C
P
V
I
P
L
R
G
R
G
I
E
A
L
K
I
A
L
D
R
H
Q
A
N
S
D
L
E
L
V
H
Y
P
Q
P
L
L
R
E
A
D
L
L
A
Q
Q
M
S
A
Q
I
P
P
R
Q
R
R
W
L
G
L
Q
M
L
E
-
G
D
I
Y
S
R
A
Y
A
G
D
A
A
D
K
L
D
I
A
L
A
N
L
S
D
----
E
I
D
D
P
A
L
H
I
A
D
A
R
Y
Q
T
I
A
A
I
C
D
A
V
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.13
41%
-67
- C7 -
3B1Y
1
?
A:
[6-164]
-----
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
A
V
E
R
-
K
S
G
L
V
K
K
N
K
D
L
E
I
Q
D
L
P
G
I
Y
S
M
S
P
Y
----
S
P
---
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
-
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
----
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
-------
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
D
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
-
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
----
F
Q
R
K
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.73
41%
-70
- C7 -
3B1W
1
?
A:
[6-164]
-----
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
-
K
S
G
L
V
K
K
N
K
D
L
E
I
Q
D
L
P
G
I
Y
S
M
S
P
Y
----
S
P
---
E
A
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
-
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
-------
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
D
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
-
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
----
F
Q
R
K
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
A
E
S
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.27
42%
-61
- C7 -
3SS8
4
?
B:
[6-164]
-----
I
A
L
I
G
N
P
N
S
G
K
T
S
L
F
N
L
I
T
G
H
N
Q
R
V
G
N
W
P
G
V
T
V
E
R
-
K
S
G
L
V
K
K
N
K
D
L
E
I
Q
D
L
P
G
I
Y
S
M
S
P
Y
----
S
P
---
E
E
K
V
A
R
D
Y
L
L
S
Q
R
A
D
S
I
L
N
V
V
D
A
T
N
L
E
R
N
L
-
Y
L
T
T
Q
L
I
E
T
G
I
P
V
T
I
A
L
N
M
I
D
V
L
D
G
Q
G
K
K
I
N
V
D
K
L
S
Y
H
L
G
V
P
V
V
A
T
S
A
L
K
Q
T
G
-------
V
D
Q
V
V
K
K
A
A
H
T
T
T
S
T
V
G
D
L
A
F
P
I
Y
D
D
R
L
E
A
A
I
S
Q
I
L
E
V
L
G
N
S
V
P
Q
-
R
S
A
R
F
Y
A
I
K
L
F
E
Q
D
S
L
V
E
A
E
L
D
L
S
Q
----
F
Q
R
K
E
I
E
D
I
I
R
I
T
E
E
I
F
T
E
D
A
E
S
I
V
I
N
E
R
Y
A
F
I
E
R
V
C
Q
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.20
43%
-81
- C7 -
2WJG
1
FEOB_METJA
B:
[5-153]
M
K
S
Y
E
I
A
L
I
G
N
P
N
V
G
K
S
T
I
F
N
A
L
T
G
E
N
V
Y
I
G
N
W
P
G
V
T
V
E
K
K
E
G
E
F
E
Y
N
G
E
K
F
K
V
V
D
L
P
G
V
Y
S
L
T
A
N
----
S
I
---
D
E
I
I
A
R
D
Y
I
I
N
E
K
P
D
L
V
V
N
I
V
D
A
T
A
L
E
R
N
L
-
Y
L
T
L
Q
L
M
E
M
G
A
N
L
L
L
A
L
N
K
M
D
L
A
K
S
L
G
I
E
I
D
V
D
K
L
E
K
I
L
G
V
K
V
V
P
L
S
A
A
K
K
M
G
I
E
E
L
K
K
A
I
S
I
A
V
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------