@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0641: (2015-12-17 )
MQDHLVNETKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGKYHPHGDTAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAVGMATSIPPHRIDEIIDALAHVLGNPNAELDKILEFVKGPDFPTGGIIYGKAGIVEAYKTGRGRVKVRAKVHVEKTKNKEIIVLGEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIKTSPSPEAAKNALIERFSLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEDRLNEVVKTELLEVKEQFSSPRRTEIQESYESIDTEDLIANEPMVVSMSYKGYVKRVDLKAYERQNRGGKGKLSGSTYEDDFIENFFVANTHDILLFITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPNEKIMATLSTKDFSDERSLAFFTKNGVVKRTNLSEFGGNRSYSGIRAIVLDEGDELVGAKVVDKNAKHLLIASYLGMFIKFPLEDVREIGRTTRGVMGIRLNENDFVVGAVVISDDSNKLLSVSENGLGKQTLAEAYREQSRGGKGVIGMKLTQKTGNLVSVISVDDENLNLMILTASAKMIRVSIKDIRETGRNASGVKLINTADKVVYVNSCPKEEEPENLETSSVQNLFE
Atome Classification :
(41 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....-..120.......130.......140.......150.......160.......170.......180.......190.......200......----.210.......220.......-230.......240.......--250-..-.-.-.-..260.......270.......280.......290.....-..-300........310-.......320.......330.......340........350.......360.......370.......380.......390.......400.......410.-------------..--------------------....420.......430.......440.......450.......460.......470.......480.......490..-......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690......------.700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
D
H
L
V
N
E
T
K
N
I
V
E
VGIDS
S
I
E
E
S
Y
L
A
Y
S
M
S
V
I
I
GRALPDARD
G
L
K
P
V
H
R
R
I
L
Y
A
M
H
E
LGLT
S
K
V
A
Y
K
K
S
A
R
I
V
G
D
V
I
GKYHPHG
D
T
A
V
Y
D
A
L
V
R
M
A
Q
D
F
S
M
R
L
E
L
VDGQGNFGSID-GDN
A
A
A
M
R
Y
T
E
A
RM
T
K
A
S
E
E
I
L
R
DIDK
D
T
IDFVPNYDDTLKEPDI
L
P
S
R
L
P
N
L
L
VNGAN
G
I
A
V
GMATSI
P
P
H
R
I
D
E
I
I
D
A
L
A
H
V
LGNPNA
E
----
L
D
K
I
L
E
F
V
KGPDFPTG
G
I
I
YG-KA
G
I
V
E
A
Y
KTGR
G
R
V
K
V
R
A
K
--
V
H
V
-EK-T-K-N-
K
E
I
I
V
L
GEMPFQT
N
K
A
K
L
V
E
Q
I
S
D
L
A
R
E
K
Q
I
E
G
I
S
E
V
RDE-SD-R-E
G
I
R
V
V
I
E
L
K
R
D
-
A
M
S
E
I
V
L
N
H
L
Y
K
LT
T
M
E
T
T
F
S
I
I
L
L
A
IY-NKE
P
K
I
F
T
L
L
E
L
L
R
L
F
L
NHR
K
T
I
I
I
R
R
T
I
F
E
L
E
K
A
K
A
R
A
H
I
L
E
G
Y
L
IALD
N
I
D
E
I
V
R
L
IKTSPS
P
E
A
A
K
N
A
L
I
-------------
E
R
--------------------
F
S
L
S
E
I
Q
S
K
A
I
L
E
M
R
L
Q
R
LTGL
E
R
D
K
I
K
E
E
Y
Q
N
L
L
E
L
I
D
D
L
N
G
I
LK
S
E
D
R
L
N
E
V
V
K
T
E
L
L
E
V
K
E
Q
FSSP
R
R
T
E
I
Q
-
E
S
Y
-ESID
T
E
D
LIANE
P
M
V
V
S
MSYKG
Y
V
K
R
V
D
L
K
A
Y
E
RQNRGGKGKLSGSTY
E
D
D
F
I
E
N
FFVANT
H
D
I
L
L
F
I
TNK
G
Q
L
Y
H
L
K
V
Y
KIP
E
A
S
R
I
A
M
G
K
A
I
V
N
L
I
SLAPN
E
K
I
M
A
T
LSTKDFSDER
S
L
A
F
F
TKNG
V
V
KRT
N
L
S
E
FGGNRSYS
G
I
R
A
I
V
LDEGD
E
L
V
G
A
K
V
VDKNA
K
H
L
L
I
A
S
Y
L
G
M
F
I
KF
P
L
E
D
V
R
E
I
G
R
TTR
G
V
M
G
I
R
LNE------N
D
F
V
V
G
A
V
V
ISDDSN
K
L
L
S
VSENGL
G
K
Q
T
L
A
E
A
Y
R
E
QSRGGK
G
V
I
G
M
K
L
TQKTG
N
L
V
S
V
I
S
VDDEN
L
N
L
M
I
L
TAS
A
K
M
I
R
V
S
I
K
D
I
R
E
TGRNASG
V
K
L
I
NTA
D
K
V
V
Y
VNSCPKEEEPENL
E
T
S
S
V
Q
N
LFE
45
HHSearch
90.72
36%
-87
* C6 *
1ZVU
-
PARC_ECOLI
A:
[28-731]
----------------------------------
D
R
A
L
P
F
I
G
D
G
L
K
P
V
Q
R
R
I
V
Y
A
M
S
E
L
G
L
----------
R
T
V
G
D
V
L
G
K
Y
H
P
H
G
D
S
A
C
Y
E
A
M
V
L
M
A
Q
P
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
W
G
A
P
D
D
P
K
S
F
A
A
M
R
Y
T
E
S
R
L
S
K
Y
S
E
L
L
L
S
E
L
G
Q
G
T
A
D
W
V
P
N
F
D
G
T
L
Q
E
P
K
M
L
P
A
R
L
P
N
I
L
L
N
G
T
T
G
I
A
V
G
M
A
T
D
I
P
P
H
N
L
R
E
V
A
Q
A
A
I
A
L
I
D
Q
P
K
T
T
----
L
D
Q
L
L
D
I
V
Q
G
P
D
Y
P
T
E
A
E
I
I
T
S
R
A
E
I
R
K
I
Y
E
N
G
R
G
S
V
R
M
R
A
V
--
W
K
K
-
E
D
--------
G
A
V
V
I
S
A
L
P
H
Q
V
S
G
A
R
V
L
E
Q
I
A
A
Q
M
R
N
K
K
L
P
M
V
D
D
L
R
D
E
-
S
D
-
H
E
N
P
T
R
L
V
I
V
P
R
S
N
R
V
D
M
D
Q
V
M
N
H
L
F
A
T
T
D
L
E
K
S
Y
R
I
N
L
N
M
I
G
L
D
G
R
P
A
V
K
N
L
L
E
I
L
S
E
W
L
V
F
R
R
D
T
V
R
R
R
L
N
Y
R
L
E
K
V
L
K
R
L
H
I
L
E
G
L
L
V
A
F
L
N
I
D
E
V
I
E
I
I
R
N
E
D
---
E
P
K
P
A
L
M
-------------
S
R
--------------------
F
G
L
T
E
T
Q
A
E
A
I
L
E
L
K
L
R
H
L
A
K
L
E
E
M
K
I
R
G
E
Q
S
E
L
E
K
E
R
D
Q
L
Q
G
I
L
A
S
E
R
K
M
N
N
L
L
K
K
E
L
Q
A
D
A
Q
A
Y
G
D
D
R
R
S
P
L
Q
E
R
E
E
A
K
A
M
S
E
H
D
M
L
P
S
E
P
V
T
I
V
L
S
Q
M
G
W
V
R
S
A
K
G
-----------------------
F
K
A
A
V
K
G
K
S
N
Q
P
V
V
F
V
D
S
T
G
R
S
Y
A
I
D
P
I
T
L
P
S
A
--
R
---
E
P
L
T
G
K
L
T
L
P
P
G
A
T
V
D
H
M
L
M
E
S
---
D
D
Q
K
L
L
M
A
S
D
A
G
Y
G
F
V
C
T
F
N
D
L
V
A
R
N
R
-
A
G
K
A
L
I
T
L
P
E
N
A
H
V
M
P
P
V
V
I
E
D
A
S
D
M
L
L
A
I
T
Q
A
G
R
M
L
M
F
P
V
S
D
L
P
Q
L
S
-
K
G
K
G
N
K
I
I
N
I
P
S
A
E
A
A
R
G
E
D
G
L
A
Q
L
Y
V
L
P
P
Q
S
T
L
T
I
H
V
G
K
R
K
I
K
L
R
P
E
E
L
Q
K
V
T
G
E
R
G
R
R
G
T
L
M
-
R
G
L
Q
R
I
D
R
V
E
I
D
-----------------------------------------------------------------------
2
PsiBlast_PDB
89.53
55%
-88
- C6 -
4BUL
4
GYRA_STAAN (first)
A:
[210-690]
-----------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
-
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
-
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
--
A
V
I
E
E
R
-
G
-
G
-
G
-
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
-
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
-------------
Q
R
--------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
-
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
88.52
52%
-92
- C6 -
2Y3P
1
GYRA_ECOLI (first)
B:
[12-520]
----------------
I
E
E
E
L
K
S
S
Y
L
D
Y
A
M
S
V
I
V
G
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
N
V
L
G
N
D
W
N
K
A
Y
K
K
S
A
R
V
V
G
D
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
D
T
I
V
R
M
A
Q
P
F
S
L
R
Y
M
L
V
D
G
Q
G
N
F
G
S
I
D
-
G
D
S
A
A
A
M
R
Y
T
E
I
R
L
A
K
I
A
H
E
L
M
A
D
L
E
K
E
T
V
D
F
V
D
N
Y
D
G
T
E
K
I
P
D
V
M
P
T
K
I
P
N
L
L
V
N
G
S
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
V
I
N
G
C
L
A
Y
I
D
D
E
D
I
S
----
I
E
G
L
M
E
H
I
P
G
P
D
F
P
T
A
A
I
I
N
G
-
R
R
G
I
E
E
A
Y
R
T
G
R
G
K
V
Y
I
R
A
R
A
E
V
E
V
-
D
A
-
K
-
T
-
G
-
R
E
T
I
I
V
H
E
I
P
Y
Q
V
N
K
A
R
L
I
E
K
I
A
E
L
V
K
E
K
R
V
E
G
I
S
A
L
R
D
E
-
S
D
-
K
-
D
G
M
R
I
V
I
E
V
K
R
D
-
A
V
G
E
V
V
L
N
N
L
Y
S
Q
T
Q
L
Q
V
S
F
G
I
N
M
V
A
L
H
-
H
G
Q
P
K
I
M
N
L
K
D
I
I
A
A
F
V
R
H
R
R
E
V
V
T
R
R
T
I
F
E
L
R
K
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
L
I
R
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
PWQLGNVAAML
E
-DAARPEWLEPEFGVRDG
L
--
Y
Y
L
T
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
L
R
I
L
G
S
A
D
R
L
M
E
V
I
R
E
E
L
E
L
V
R
E
Q
F
G
D
K
R
R
T
E
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
87.98
58%
-86
- C6 -
4DDQ
1
GYRA_BACSU
B:
[33-489]
-----------------------------------
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
A
M
N
D
L
G
M
T
S
D
K
P
Y
K
K
S
A
R
I
V
G
E
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
E
S
M
V
R
M
A
Q
D
F
N
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
V
D
-
G
D
S
A
A
A
M
R
Y
T
E
A
R
M
S
K
I
S
M
E
I
L
R
D
I
T
K
D
T
I
D
Y
Q
D
N
Y
D
G
S
E
R
E
P
V
V
M
P
S
R
F
P
N
L
L
V
N
G
A
A
G
I
A
V
G
M
A
T
N
I
P
P
H
Q
L
G
E
I
I
D
G
V
L
A
V
S
E
N
P
D
I
T
----
I
P
E
L
M
E
V
I
P
G
P
D
F
P
T
A
G
Q
I
L
G
-
R
S
G
I
R
K
A
Y
E
S
G
R
G
S
I
T
I
R
A
K
--
A
E
I
-
E
Q
-
T
-
S
-
S
G
K
E
R
I
I
V
T
E
L
P
Y
Q
V
N
K
A
K
L
I
E
K
I
A
D
L
V
R
D
K
K
I
E
G
I
T
D
L
R
D
E
-
S
D
-
R
-
T
G
M
R
I
V
I
E
I
R
R
D
-
A
N
A
N
V
I
L
N
N
L
Y
K
Q
T
A
L
Q
T
S
F
G
I
N
L
L
A
L
V
-
D
G
Q
P
K
V
L
T
L
K
Q
C
L
E
H
Y
L
D
H
Q
K
V
V
I
R
R
R
T
A
Y
E
L
R
K
A
E
A
R
A
H
I
L
E
G
L
R
V
A
L
D
H
L
D
A
V
I
S
L
I
R
N
S
Q
T
A
E
I
A
R
T
G
L
I
-------------
E
Q
--------------------
F
S
L
T
E
K
Q
A
Q
A
I
L
D
M
R
L
Q
R
L
T
G
L
E
R
E
K
I
E
E
E
Y
Q
S
L
V
K
L
I
A
E
L
K
D
I
L
A
N
E
Y
K
V
L
E
I
I
R
E
E
L
T
E
I
K
E
R
F
N
D
E
R
R
T
E
I
V
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.87
58%
-86
- C6 -
4DDQ
2
GYRA_BACSU
F:
[34-489]
------------------------------------
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
A
M
N
D
L
G
M
T
S
D
K
P
Y
K
K
S
A
R
I
V
G
E
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
E
S
M
V
R
M
A
Q
D
F
N
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
V
D
-
G
D
S
A
A
A
M
R
Y
T
E
A
R
M
S
K
I
S
M
E
I
L
R
D
I
T
K
D
T
I
D
Y
Q
D
N
Y
D
G
S
E
R
E
P
V
V
M
P
S
R
F
P
N
L
L
V
N
G
A
A
----
G
M
A
T
N
I
P
P
H
Q
L
G
E
I
I
D
G
V
L
A
V
S
E
N
P
D
I
T
----
I
P
E
L
M
E
V
I
P
G
P
D
F
P
T
A
G
Q
I
L
G
-
R
S
G
I
R
K
A
Y
E
S
G
R
G
S
I
T
I
R
A
K
--
A
E
I
-
E
Q
-
T
-
S
-
S
G
K
E
R
I
I
V
T
E
L
P
Y
Q
V
N
K
A
K
L
I
E
K
I
A
D
L
V
R
D
K
K
I
E
G
I
T
D
L
R
D
E
-
S
D
-
R
-
T
G
M
R
I
V
I
E
I
R
R
D
-
A
N
A
N
V
I
L
N
N
L
Y
K
Q
T
A
L
Q
T
S
F
G
I
N
L
L
A
L
V
-
D
G
Q
P
K
V
L
T
L
K
Q
C
L
E
H
Y
L
D
H
Q
K
V
V
I
R
R
R
T
A
Y
E
L
R
K
A
E
A
R
A
H
I
L
E
G
L
R
V
A
L
D
H
L
D
A
V
I
S
L
I
R
N
S
Q
T
A
E
I
A
R
T
G
L
I
-------------
E
Q
--------------------
F
S
L
T
E
K
Q
A
Q
A
I
L
D
M
R
L
Q
R
L
T
G
L
E
R
E
K
I
E
E
E
Y
Q
S
L
V
K
L
I
A
E
L
K
D
I
L
A
N
E
Y
K
V
L
E
I
I
R
E
E
L
T
E
I
K
E
R
F
N
D
E
R
R
T
E
I
V
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.87
52%
-89
- C6 -
2Y3P
1
GYRA_ECOLI (first)
A:
[22-520]
--------------------------
D
Y
A
M
S
V
I
V
G
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
N
V
L
G
N
D
W
N
K
A
Y
K
K
S
A
R
V
V
G
D
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
D
T
I
V
R
M
A
Q
P
F
S
L
R
Y
M
L
V
D
G
Q
G
N
F
G
S
I
D
-
G
D
S
A
A
A
M
R
Y
T
E
I
R
L
A
K
I
A
H
E
L
M
A
D
L
E
K
E
T
V
D
F
V
D
N
Y
D
G
T
E
K
I
P
D
V
M
P
T
K
I
P
N
L
L
V
N
G
S
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
V
I
N
G
C
L
A
Y
I
D
D
E
D
I
S
----
I
E
G
L
M
E
H
I
P
G
P
D
F
P
T
A
A
I
I
N
G
-
R
R
G
I
E
E
A
Y
R
T
G
R
G
K
V
Y
I
R
A
R
A
E
V
E
V
-
D
A
-
K
-
T
-
G
-
R
E
T
I
I
V
H
E
I
P
Y
Q
V
N
K
A
R
L
I
E
K
I
A
E
L
V
K
E
K
R
V
E
G
I
S
A
L
R
D
E
-
S
D
-
K
-
D
G
M
R
I
V
I
E
V
K
R
D
-
A
V
G
E
V
V
L
N
N
L
Y
S
Q
T
Q
L
Q
V
S
F
G
I
N
M
V
A
L
H
-
H
G
Q
P
K
I
M
N
L
K
D
I
I
A
A
F
V
R
H
R
R
E
V
V
T
R
R
T
I
F
E
L
R
K
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
L
I
R
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
P
W
Q
LGNVAAML
E
-DAARPEWLEPEFGVRDG
L
--
Y
Y
L
T
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
L
R
I
L
G
S
A
D
R
L
M
E
V
I
R
E
E
L
E
L
V
R
E
Q
F
G
D
K
R
R
T
E
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.79
55%
-85
- C6 -
2XCR
3
GYRA_STAAN (first)
D:
[244-724]
-----------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
-
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
-
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
--
A
V
I
E
E
R
-
G
-
G
-
G
-
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
-
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
-------------
Q
R
--------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
-
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
87.79
55%
-88
- C6 -
2XCR
3
GYRA_STAAN (first)
U:
[244-724]
-----------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
-
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
-
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
--
A
V
I
E
E
R
-
G
-
G
-
G
-
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
-
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
-------------
Q
R
--------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
-
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.55
58%
-83
- C6 -
4DDQ
1
GYRA_BACSU
A:
[32-489]
----------------------------------
S
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
A
M
N
D
L
G
M
T
S
D
K
P
Y
K
K
S
A
R
I
V
G
E
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
E
S
M
V
R
M
A
Q
D
F
N
Y
R
Y
M
L
V
D
G
H
G
N
F
G
S
V
D
-
G
D
S
A
A
A
M
R
Y
T
E
A
R
M
S
K
I
S
M
E
I
L
R
D
I
T
K
D
T
I
D
Y
Q
D
N
Y
D
G
S
E
R
E
P
V
V
M
P
S
R
F
P
N
L
L
V
N
G
A
A
G
I
A
V
G
M
A
T
N
I
P
P
H
Q
L
G
E
I
I
D
G
V
L
A
V
S
E
N
P
D
I
T
----
I
P
E
L
M
E
V
I
P
G
P
D
F
P
T
A
G
Q
I
L
G
-
R
S
G
I
R
K
A
Y
E
S
G
R
G
S
I
T
I
R
A
K
--
A
E
I
-
E
Q
-
T
-
S
-
S
G
K
E
R
I
I
V
T
E
L
P
Y
Q
V
N
K
A
K
L
I
E
K
I
A
D
L
V
R
D
K
K
I
E
G
I
T
D
L
R
D
E
-
S
D
-
R
-
T
G
M
R
I
V
I
E
I
R
R
D
-
A
N
A
N
V
I
L
N
N
L
Y
K
Q
T
A
L
Q
T
S
F
G
I
N
L
L
A
L
V
-
D
G
Q
P
K
V
L
T
L
K
Q
C
L
E
H
Y
L
D
H
Q
K
V
V
I
R
R
R
T
A
Y
E
L
R
K
A
E
A
R
A
H
I
L
E
G
L
R
V
A
L
D
H
L
D
A
V
I
S
L
I
R
N
S
Q
T
A
E
I
A
R
T
G
L
I
-------------
E
Q
--------------------
F
S
L
T
E
K
Q
A
Q
A
I
L
D
M
R
L
Q
R
L
T
G
L
E
R
E
K
I
E
E
E
Y
Q
S
L
V
K
L
I
A
E
L
K
D
I
L
A
N
E
Y
K
V
L
E
I
I
R
E
E
L
T
E
I
K
E
R
F
N
D
E
R
R
T
E
I
V
-
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.43
55%
-86
- C6 -
2XCR
3
GYRA_STAAN (first)
B:
[244-724]
-----------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
-
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
-
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
--
A
V
I
E
E
R
-
G
-
G
-
G
-
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
-
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
-------------
Q
R
--------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
-
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
87.42
52%
-89
- C6 -
1AB4
-
GYRA_ECOLI
A:
[30-521]
---------------------------------
V
G
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
N
V
L
G
N
D
W
N
K
A
Y
K
K
S
A
R
V
V
G
D
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
D
T
I
V
R
M
A
Q
P
F
S
L
R
Y
M
L
V
D
G
Q
G
N
F
G
S
I
D
-
G
D
S
A
A
A
M
R
Y
T
E
I
R
L
A
K
I
A
H
E
L
M
A
D
L
E
K
E
T
V
D
F
V
D
N
Y
D
G
T
E
K
I
P
D
V
M
P
T
K
I
P
N
L
L
V
N
G
S
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
V
I
N
G
C
L
A
Y
I
D
D
E
D
I
S
----
I
E
G
L
M
E
H
I
P
G
P
D
F
P
T
A
A
I
I
N
G
-
R
R
G
I
E
E
A
Y
R
T
G
R
G
K
V
Y
I
R
A
R
A
E
V
E
V
-----------
E
T
I
I
V
H
E
I
P
Y
Q
V
N
K
A
R
L
I
E
K
I
A
E
L
V
K
E
K
R
V
E
G
I
S
A
L
R
D
E
-
S
D
-
K
-
D
G
M
R
I
V
I
E
-------
G
E
V
V
L
N
N
L
Y
S
Q
T
Q
L
Q
V
S
F
G
I
N
M
V
A
L
H
-
H
G
Q
P
K
I
M
N
L
K
D
I
I
A
A
F
V
R
H
R
R
E
V
V
T
R
R
T
I
F
E
L
R
K
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
L
I
R
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
P
W
Q
L
G
NVAAML
E
-DAARPEWLEPEFGVRDG
L
--
Y
Y
L
T
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
L
R
I
L
G
S
A
D
R
L
M
E
V
I
R
E
E
L
E
L
V
R
E
Q
F
G
D
K
R
R
T
E
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
87.32
55%
-82
- C6 -
2XCR
3
GYRA_STAAN (first)
S:
[244-724]
-----------
I
N
E
R
N
I
T
S
E
M
R
E
S
F
L
D
Y
A
M
S
V
I
V
A
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
I
L
Y
G
L
N
E
Q
G
M
T
P
D
K
S
Y
K
K
S
A
R
I
V
G
D
V
M
G
K
Y
H
P
H
G
D
S
S
I
Y
E
A
M
V
R
M
A
Q
D
F
S
Y
R
Y
P
L
V
D
G
Q
G
N
F
G
S
M
D
-
G
D
G
A
A
A
M
R
F
T
E
A
R
M
T
K
I
T
L
E
L
L
R
D
I
N
K
D
T
I
D
F
I
D
N
Y
D
G
N
E
R
E
P
S
V
L
P
A
R
F
P
N
L
L
A
N
G
A
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
L
I
N
G
V
L
S
L
S
K
N
P
D
I
S
----
I
A
E
L
M
E
D
I
E
G
P
D
F
P
T
A
G
L
I
L
G
-
K
S
G
I
R
R
A
Y
E
T
G
R
G
S
I
Q
M
R
S
R
--
A
V
I
E
E
R
-
G
-
G
-
G
-
R
Q
R
I
V
V
T
E
I
P
F
Q
V
N
K
A
R
M
I
E
K
I
A
E
L
V
R
D
K
K
I
D
G
I
T
D
L
R
D
E
-
T
S
L
R
-
T
G
V
R
V
V
I
D
V
R
K
D
-
A
N
A
S
V
I
L
N
N
L
Y
K
Q
T
P
L
Q
T
S
F
G
V
N
M
I
A
L
V
-
N
G
R
P
K
L
I
N
L
K
E
A
L
V
H
Y
L
E
H
Q
K
T
V
V
R
R
R
T
Q
Y
N
L
R
K
A
K
D
R
A
H
I
L
E
G
L
R
I
A
L
D
H
I
D
E
I
I
S
T
I
R
E
S
D
T
D
K
V
A
M
E
S
L
Q
-------------
Q
R
--------------------
F
K
L
S
E
K
Q
A
Q
A
I
L
D
M
R
L
R
R
L
T
G
L
E
R
D
K
I
E
A
E
Y
N
E
L
L
N
Y
I
S
E
L
E
T
I
L
A
D
E
E
V
L
L
Q
L
V
R
D
E
L
T
E
I
R
D
R
F
G
D
D
R
R
T
E
I
Q
-
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.24
52%
-88
- C6 -
4TMA
-
?
A:
[17-521]
--------------------
L
K
S
S
Y
L
D
Y
A
M
S
V
I
V
G
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
N
V
L
G
N
D
W
N
K
A
Y
K
K
S
A
R
V
V
G
D
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
D
T
I
V
R
M
A
Q
P
F
S
L
R
Y
M
L
V
D
G
Q
G
N
F
G
S
I
D
-
G
D
S
A
A
A
M
R
Y
T
E
I
R
L
A
K
I
A
H
E
L
M
A
D
L
E
K
E
T
V
D
F
V
D
N
Y
D
G
T
E
K
I
P
D
V
M
P
T
K
I
P
N
L
L
V
N
G
S
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
V
I
N
G
C
L
A
Y
I
D
D
E
D
I
S
----
I
E
G
L
M
E
H
I
P
G
P
D
F
P
T
A
A
I
I
N
G
-
R
R
G
I
E
E
A
Y
R
T
G
R
G
K
V
Y
I
R
A
R
A
E
V
E
V
-
D
A
-
K
-
T
-
G
-
R
E
T
I
I
V
H
E
I
P
Y
Q
V
N
K
A
R
L
I
E
K
I
A
E
L
V
K
E
K
R
V
E
G
I
S
A
L
R
D
E
-
S
D
-
K
-
D
G
M
R
I
V
I
E
V
K
R
D
-
A
V
G
E
V
V
L
N
N
L
Y
S
Q
T
Q
L
Q
V
S
F
G
I
N
M
V
A
L
H
-
H
G
Q
P
K
I
M
N
L
K
D
I
I
A
A
F
V
R
H
R
R
E
V
V
T
R
R
T
I
F
E
L
R
K
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
L
I
R
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
PWQLNVA
A
M
L
-
E
R
A
GDDAARPEWLEPEFGVDGL
Y
Y
L
-
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
L
R
I
L
G
S
A
D
R
L
M
E
V
I
R
E
E
L
E
L
V
R
E
Q
F
G
D
K
R
R
T
E
I
T
-
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
86.67
52%
-91
- C6 -
4TMA
1
?
E:
[26-521]
-----------------------------
M
S
V
I
V
G
R
A
L
P
D
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
N
V
L
G
N
D
W
N
K
A
Y
K
K
S
A
R
V
V
G
D
V
I
G
K
Y
H
P
H
G
D
S
A
V
Y
D
T
I
V
R
M
A
Q
P
F
S
L
R
Y
M
L
V
D
G
Q
G
N
F
G
S
I
D
-
G
D
S
A
A
A
M
R
Y
T
E
I
R
L
A
K
I
A
H
E
L
M
A
D
L
E
K
E
T
V
D
F
V
D
N
Y
D
G
T
E
K
I
P
D
V
M
P
T
K
I
P
N
L
L
V
N
G
S
S
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
T
E
V
I
N
G
C
L
A
Y
I
D
D
E
D
I
S
----
I
E
G
L
M
E
H
I
P
G
P
D
F
P
T
A
A
I
I
N
G
-
R
R
G
I
E
E
A
Y
R
T
G
R
G
K
V
Y
I
R
A
R
A
E
V
E
V
-
D
A
-
K
-
T
-
G
-
R
E
T
I
I
V
H
E
I
P
Y
Q
V
N
K
A
R
L
I
E
K
I
A
E
L
V
K
E
K
R
V
E
G
I
S
A
L
R
D
E
-
S
D
-
K
-
D
G
M
R
I
V
I
E
V
K
R
D
-
A
V
G
E
V
V
L
N
N
L
Y
S
Q
T
Q
L
Q
V
S
F
G
I
N
M
V
A
L
H
-
H
G
Q
P
K
I
M
N
L
K
D
I
I
A
A
F
V
R
H
R
R
E
V
V
T
R
R
T
I
F
E
L
R
K
A
R
D
R
A
H
I
L
E
A
L
A
V
A
L
A
N
I
D
P
I
I
E
L
I
R
H
A
P
T
P
A
E
A
K
T
A
L
V
A
N
PWQLGNML---
E
R
AGARPEWLEFGVRDG---------
E
Q
Q
A
Q
A
I
L
D
L
R
L
Q
K
L
T
G
L
E
H
E
K
L
L
D
E
Y
K
E
L
L
D
Q
I
A
E
L
L
R
I
L
G
S
A
D
R
L
M
E
V
I
R
E
E
L
E
L
V
R
E
Q
F
G
D
K
R
R
T
E
I
T
-
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
83.70
44%
-83
- C6 -
4KOE
5
PARC_STRPN
A:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
83.29
44%
-83
- C6 -
3RAD
5
PARC_STRPN
A:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
83.29
44%
-89
- C6 -
3KSB
2
PARC_STRPN
A:
[3-483]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
---------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
---
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
83.25
44%
-89
- C6 -
3KSB
2
PARC_STRPN
B:
[3-483]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
---------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
---
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
83.23
44%
-82
- C6 -
3RAF
5
PARC_STRPN
A:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
83.20
44%
-85
- C6 -
4KPF
5
PARC_STRPN
A:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
83.07
44%
-87
- C6 -
4KPE
5
PARC_STRPN
A:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
83.02
44%
-84
- C6 -
3RAE
4
PARC_STRPN
A:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
83.00
44%
-83
- C6 -
3K9F
4
PARC_STRPN
B:
[3-483]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
82.94
47%
-87
- C6 -
3IFZ
2
GYRA_MYCTU
B:
[29-498]
-------------------------
I
D
Y
A
M
S
V
I
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
-
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
-
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
--
V
E
V
-
E
E
D
S
-
R
-
G
-
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
S
D
-
R
-
V
G
L
R
I
V
I
E
I
K
R
D
-
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
-
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
-------------
E
L
--------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
-
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
82.93
44%
-86
- C6 -
3RAF
5
PARC_STRPN
B:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
82.93
44%
-84
- C6 -
4KOE
5
PARC_STRPN
B:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
82.91
44%
-83
- C6 -
3RAE
4
PARC_STRPN
B:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.89
44%
-83
- C6 -
3K9F
4
PARC_STRPN
A:
[3-483]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
82.80
44%
-88
- C6 -
3KSA
2
PARC_STRPN
A:
[3-483]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
---------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
82.74
44%
-88
- C6 -
3RAD
6
PARC_STRPN
B:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.72
48%
-88
- C6 -
3ILW
4
GYRA_MYCTU
A:
[7-468]
---------------------------------
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
-
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
-
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
--
V
E
V
-
E
E
D
S
-
R
-
G
-
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
S
D
-
R
-
V
G
L
R
I
V
I
E
I
K
R
D
-
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
-
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
-------------
E
L
--------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
-
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
82.63
44%
-89
- C6 -
3KSA
2
PARC_STRPN
B:
[3-483]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
---------
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
-
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
82.63
48%
-86
- C6 -
3ILW
4
GYRA_MYCTU
B:
[8-468]
----------------------------------
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
-
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
-
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
--
V
E
V
-
E
E
D
S
-
R
-
G
-
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
S
D
-
R
-
V
G
L
R
I
V
I
E
I
K
R
D
-
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
-
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
-------------
E
L
--------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
-
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
82.51
47%
-87
- C6 -
3IFZ
2
GYRA_MYCTU
A:
[15-498]
-----------
I
E
P
V
D
I
E
Q
E
M
Q
R
S
Y
I
D
Y
A
M
S
V
I
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
-
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
-
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
--
V
E
V
-
E
E
D
S
-
R
------
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
S
S
D
-
R
-
V
G
L
R
I
V
I
E
I
K
R
D
-
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
-
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
-------------
E
L
--------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
82.49
44%
-84
- C6 -
3LTN
4
PARC_STRPN
B:
[3-483]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
82.47
44%
-84
- C6 -
3LTN
4
PARC_STRPN
A:
[3-483]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
82.46
48%
-87
- C6 -
3ILW
4
GYRA_MYCTU
A:
[7-469]
---------------------------------
V
G
R
A
L
P
E
V
R
D
G
L
K
P
V
H
R
R
V
L
Y
A
M
F
D
S
G
F
R
P
D
R
S
H
A
K
S
A
R
S
V
A
E
T
M
G
N
Y
H
P
H
G
D
A
S
I
Y
D
S
L
V
R
M
A
Q
P
W
S
L
R
Y
P
L
V
D
G
Q
G
N
F
G
S
P
G
-
N
D
P
P
A
A
M
R
Y
T
E
A
R
L
T
P
L
A
M
E
M
L
R
E
I
D
E
E
T
V
D
F
I
P
N
Y
D
G
R
V
Q
E
P
T
V
L
P
S
R
F
P
N
L
L
A
N
G
S
G
G
I
A
V
G
M
A
T
N
I
P
P
H
N
L
R
E
L
A
D
A
V
F
W
A
L
E
N
H
D
A
D
E
E
E
T
L
A
A
V
M
G
R
V
K
G
P
D
F
P
T
A
G
L
I
V
G
-
S
Q
G
T
A
D
A
Y
K
T
G
R
G
S
I
R
M
R
G
V
--
V
E
V
-
E
E
-
D
S
R
-
G
-
R
T
S
L
V
I
T
E
L
P
Y
Q
V
N
H
D
N
F
I
T
S
I
A
E
Q
V
R
D
G
K
L
A
G
I
S
N
I
E
D
Q
-
S
S
-
D
R
V
G
L
R
I
V
I
E
I
K
R
D
-
A
V
A
K
V
V
I
N
N
L
Y
K
H
T
Q
L
Q
T
S
F
G
A
N
M
L
A
I
V
-
D
G
V
P
R
T
L
R
L
D
Q
L
I
R
Y
Y
V
D
H
Q
L
D
V
I
V
R
R
T
T
Y
R
L
R
K
A
N
E
R
A
H
I
L
R
G
L
V
K
A
L
D
A
L
D
E
V
I
A
L
I
R
A
S
E
T
V
D
I
A
R
A
G
L
I
-------------
E
L
--------------------
L
D
I
D
E
I
Q
A
Q
A
I
L
D
M
Q
L
R
R
L
A
A
L
E
R
Q
R
I
I
D
D
L
A
K
I
E
A
E
I
A
D
L
E
D
I
L
A
K
P
E
R
Q
R
G
I
V
R
D
E
L
A
E
I
V
D
R
H
G
D
D
R
R
T
R
I
I
-
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
82.34
44%
-85
- C6 -
4KPE
6
PARC_STRPN
B:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.25
44%
-85
- C6 -
4KPF
5
PARC_STRPN
B:
[3-484]
----------
N
I
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
T
F
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
G
S
T
G
I
S
A
G
Y
A
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
G
A
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
K
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
P
Y
E
I
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
A
G
I
A
E
V
R
D
E
-
S
D
-
R
-
D
G
L
R
I
A
I
E
L
K
K
D
-
A
N
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
S
S
L
E
-
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
77.85
44%
-79
- C6 -
3FOE
3
PARC_STRPN
A:
[5-479]
------------
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
--
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
D
I
E
K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
----------
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
-
K
----
I
D
K
L
M
E
F
L
P
G
P
D
F
P
T
--
I
I
Q
G
-
R
D
E
I
K
K
A
Y
E
T
G
-
G
R
V
V
V
R
S
K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
E
Q
I
V
I
T
E
I
----
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
---------------------
I
E
L
------
T
E
L
V
L
N
Y
L
F
K
Y
T
D
L
Q
I
N
Y
N
F
N
M
V
A
I
D
-
N
F
T
P
R
Q
V
G
I
V
P
I
L
S
S
Y
I
A
H
R
R
E
V
I
L
A
R
S
R
F
D
K
E
K
A
E
K
R
L
H
I
V
E
G
L
I
R
V
I
S
I
L
D
E
V
I
A
L
I
R
A
S
E
N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
E
E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
T
N
T
D
V
V
V
L
Q
E
E
E
A
E
L
R
E
K
I
A
M
L
A
A
I
I
G
D
E
R
T
M
Y
N
L
M
K
K
E
L
R
E
V
K
K
K
F
A
T
P
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.82
44%
-83
- C6 -
3FOF
3
PARC_STRPN
A:
[5-479]
------------
Q
N
M
S
L
E
D
I
M
G
E
R
F
G
R
Y
S
K
Y
I
I
Q
D
R
A
L
P
D
I
R
D
G
L
K
P
V
Q
R
R
I
L
Y
S
M
N
K
D
S
N
--
D
K
S
Y
R
K
S
A
K
S
V
G
N
I
M
G
N
F
H
P
H
G
D
S
S
I
Y
D
A
M
V
R
M
S
Q
N
W
K
N
R
E
I
L
V
E
M
H
G
N
N
G
S
M
D
-
G
D
P
P
A
A
M
R
Y
T
E
A
R
L
S
E
I
A
G
Y
L
L
Q
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K
K
T
V
P
F
A
W
N
F
D
D
T
E
K
E
P
T
V
L
P
A
A
F
P
N
L
L
V
N
----------
T
D
I
P
P
H
N
L
A
E
V
I
D
A
A
V
Y
M
I
D
H
P
T
A
K
----
I
D
K
L
M
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F
L
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G
P
D
F
P
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G
A
I
I
Q
G
-
R
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K
A
Y
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G
-
G
R
V
V
V
R
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K
--
T
E
I
-
E
K
-
L
-
K
G
G
-
K
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Q
I
V
I
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I
----
N
K
A
N
L
V
K
K
I
D
D
V
R
V
N
N
K
V
---------------------
I
E
L
------
T
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L
V
L
N
Y
L
F
K
Y
T
D
L
Q
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N
Y
N
F
N
M
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-
N
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Q
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G
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V
P
I
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Y
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R
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A
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A
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A
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N
K
A
D
A
K
E
N
L
K
-------------
V
S
--------------------
Y
D
F
T
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E
Q
A
E
A
I
V
T
L
Q
L
Y
R
L
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N
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R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------